Pesquisa | SciELO

Abstract Objective Summarize the evidence on drug therapies for obstructive sleep apnea. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. PubMed, Embase, Scopus, Web of Science, SciELO, LILACS, Scopus, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched on February 17th, 2023. A search strategy retrieved randomized clinical trials comparing the Apnea-Hypopnea Index (AHI) in pharmacotherapies. Studies were selected and data was extracted by two authors independently. The risk of bias was assessed using the Cochrane Risk of Bias tool. RevMan 5.4. was used for data synthesis. Results 4930 articles were obtained, 68 met inclusion criteria, and 29 studies (involving 11 drugs) were combined in a meta-analysis. Atomoxetine plus oxybutynin vs placebo in AHI mean difference of -7.71 (-10.59, -4.83) [Fixed, 95 % CI, I2 = 50 %, overall effect: Z = 5.25, p < 0.001]. Donepezil vs placebo in AHI mean difference of -8.56 (-15.78, -1.33) [Fixed, 95 % CI, I2 = 21 %, overall effect: Z = 2.32, p = 0.02]. Sodium oxybate vs placebo in AHI mean difference of -5.50 (-9.28, -1.73) [Fixed, 95 % CI, I2 = 32 %, overall effect: Z = 2.86, p = 0.004]. Trazodone vs placebo in AHI mean difference of -12.75 (-21.30, -4.19) [Fixed, 95 % CI, I2 = 0 %, overall effect: Z = 2.92, p = 0.003]. Conclusion The combination of noradrenergic and antimuscarinic drugs shows promising results. Identifying endotypes may be the key to future drug therapies for obstructive sleep apnea. Moreover, studies with longer follow-up assessing the safety and sustained effects of these treatments are needed. PROSPERO registration number CRD42022362639. apnea MetaAnalyses Meta Analyses PRISMA (PRISMA followed PubMed Embase Scopus Science SciELO LILACS Trials ClinicalTrialsgov ClinicalTrials gov 17th th 2023 ApneaHypopnea Apnea Hypopnea (AHI pharmacotherapies independently tool 54 5 4 5.4 synthesis 493 obtained 6 criteria 2 involving 1 metaanalysis. metaanalysis meta analysis. analysis meta-analysis 7.71 771 7 71 -7.7 10.59, 1059 10 59 (-10.59 4.83 483 83 -4.83 Fixed, Fixed [Fixed 9 CI I effect 525 25 5.25 0.001. 0001 0.001 . 001 0.001] 8.56 856 8 56 -8.5 15.78, 1578 15 78 (-15.78 1.33 133 33 -1.33 232 2.32 0.02. 002 0.02 02 0.02] 5.50 550 -5.5 9.28, 928 28 (-9.28 1.73 173 73 -1.73 3 286 86 2.86 0.004. 0004 0.004 004 0.004] 12.75 1275 12 75 -12.7 21.30, 2130 30 (-21.30 4.19 419 19 -4.19 292 92 2.92 0.003. 0003 0.003 003 0.003] results Moreover followup follow up needed CRD42022362639 CRD 202 5. 49 7.7 77 -7. 10.59 105 (-10.5 4.8 48 -4.8 52 5.2 000 0.00 00 8.5 85 -8. 15.78 157 (-15.7 1.3 13 -1.3 23 2.3 0.0 5.5 55 -5. 9.28 (-9.2 1.7 17 -1.7 2.8 12.7 127 -12. 21.30 213 (-21.3 4.1 41 -4.1 2.9 CRD4202236263 20 7. -7 10.5 (-10. 4. -4. 8. -8 15.7 (-15. 1. -1. 2. 0. -5 9.2 (-9. 12. -12 21.3 (-21. CRD420223626 - 10. (-10 -4 15. (-15 -1 9. (-9 21. (-21 CRD42022362 (-1 (- (-2 CRD4202236 ( CRD420223 CRD42022 CRD4202 CRD420 CRD42 CRD4

https://doi.org/10.1016/j.clinsp.2024.100330

Biogran Grafting in Rat Tibia Defects - A Model of High Bone Metabolism Site
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Ferreira, Luiza de Almeida Queiroz

; Lehman, Luiz Felipe Cardoso

; Diniz, Marina Gonçalves

; Ferreira, Anderson José

; Silva, Rosangela Maria Ferreira da Costa e

; Silva, Tarcília Aparecida

; Mesquita, Ricardo Alves

; Oliveira, Rafaela Férrer de

; Noronha, Mariana Saturnino

; Leão, Daniel Marques

; Andrade, Ângela Leão

; Domingues, Rosana Zacarias

; Diniz, Ivana Márcia Alves

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24230003

Resumo: En | Texto: En | PDF: En

Abstract We investigated the Biogran on bone repair and metabolism at several time-intervals upon grafting into rat tibia artificial defects. The biomaterial was thoroughly characterized in vitro, and its dissolution behavior upon immersion was assessed in simulated body fluid (SBF) solution for 1, 3, 7, 14, and 30 days. Biogran was also assessed by in vitro hydroxyapatite formation in SBF solution, which is a marker for bioactive behavior. In vivo, distal and proximal bone defects were performed in the Wistar rat's right tibia and filled according to the experimental groups: I) negative control, no filling; II) positive control, 10 mg of autogenous bone; and III) 10 mg of Biogran. Animals were euthanized at 1, 2, 3, 4, 7, and 10 weeks. Bone neoformation was analyzed using histomorphometry (proximal defect), and local levels of bone morphogenetic protein 2 (BMP-2) were measured using the ELISA assay (distal defect). In vitro, the Biogran sample showed a fast dissolution rate within the first 7 days, parallel to the formation of the hydroxyapatite layer. In vivo, the sample was progressively resorbed at a higher rate within the first month until it became almost absent at week 10th. The sample presented similar or higher bone neoformation concerning the autogenous bone. BMP-2 levels were sustained in the Biogran group (around 200 pg/mg) and detected until the last experimental time with a significant difference compared with the controls. Results suggest Biogran is a candidate for hard tissue engineering even in highly active bone remodeling sites. timeintervals intervals (SBF 1 3 14 days vivo rats s groups I control filling II III 4 weeks defect, defect , defect) BMP2 BMP (BMP-2 defect. . layer 10th th BMP- around 20 pg/mg pgmg pg controls sites (BMP- (BMP

https://doi.org/10.1590/1678-4324-2024230003

Salivary Changes, Systemic Conditions, and Medication Use in Independently-Living Aged: A Cross-Sectional Study Changes Conditions IndependentlyLiving Independently Living Aged CrossSectional Cross Sectional
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Branco, Natália Teixeira Tavares

; Ribeiro, Rafaela de Brito

; Dutra, Daniel José Braga

; Ferreira, Raquel Conceição

; Diniz, Ivana Márcia Alves

; Magalhães, Cláudia Silami

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2024, Volume 24 elocation e220076

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To determine the unstimulated salivary flow, pH, and buffering capacity and their associations with systemic conditions and medication use in independently living aged. Material and Methods: This cross-sectional study included 72 participants with a minimum of 60 years recruited in Belo Horizonte, Brazil. A questionnaire was used to collect age, sex, presence of systemic diseases, and medications in continuous use. Salivary data collection was performed to determine unstimulated salivary flow, pH, and buffering capacity. Descriptive, bivariate, and multivariate analyses were performed (p<0.05). Results: Most of the sample had at least one systemic disease (81.9%) and used at least one medication (79.2%). Female participants (p=0.01), those with five or more systemic diseases (p<0.01), and hypertension (p=0.04) had reduced salivary flow. Participants with systemic diseases (p=0.02), taking any medication (p=0.04), in a polypharmacy regimen, and presenting hypertension (p=0.02) had more acidic salivary pH. Participants with diabetes had average salivary buffering capacity (p=0.02). In the adjusted multiple regression models, no explanatory variable was significantly associated with the salivary outcomes. Conclusion: Systemic alterations and medication use appear to be related to salivary changes in older adults. Integrative assessment of older adults is fundamental to identifying and controlling the factors that may modify their salivary characteristics. Objective flow pH aged Methods crosssectional cross sectional 7 6 Horizonte Brazil age sex Descriptive bivariate p<0.05. p005 p p<0.05 . 0 05 (p<0.05) Results 81.9% 819 81 9 (81.9% 79.2%. 792 79.2% 79 2 (79.2%) p=0.01, p001 p=0.01 , 01 (p=0.01) p<0.01, p<0.01 (p<0.01) p=0.04 p004 04 (p=0.04 p=0.02, p002 p=0.02 02 p=0.04, regimen (p=0.02 p=0.02. models outcomes Conclusion characteristics p00 p<0.0 (p<0.05 81.9 8 (81.9 79.2 (79.2% p=0.0 (p=0.01 (p<0.01 (p=0.0 p0 p<0. (p<0.0 81. (81. 79. (79.2 p=0. (p=0. p<0 (p<0. (81 (79. p=0 (p=0 p< (p<0 (8 (79 p= (p= (p< ( (7 (p

https://doi.org/10.1590/pboci.2024.052

Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort: comparison with INTERGROWTH cohort
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Cardoso, Viviane Cunha

; Grandi, Carlos

; Silveira, Rita C.

; Duarte, José Luiz Bandeira

; Viana, Maria Cândida Ferrarez Bouzada

; Ferreira, Daniela Marques de Lima Mota

; Alves Junior, José Mariano Sales

; Embrizi, Laís Furlan

; Gimenes, Carolina Boschi

; Mello e Silva, Nathalia Moura de

; Melo, Fernanda Pegoraro de Godoi

; Venzon, Paulyne Stadler

; Gomez, Dafne Barcala

; Vale, Marynéa Silva do

; Bentlin, Maria Regina

; Barros, Marina Carvalho de Moraes

; Bigélli, Laura Emilia Monteiro

; Diniz, Edna Maria de Albuquerque

; Luz, Jorge Hecker

; Marba, Sérgio Tadeu Martins

; Almeida, João Henrique Carvalho Leme de

; Aragon, Davi Casale

; Carmona, Fabio

Jornal de Pediatria

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Jan 2023, Volume 99 Nº 1 Páginas 86 - 93

Resumo: En | Texto: En | PDF: En

Abstract Objective: To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21). Methods: Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals. Outcome: the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes: small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21. Results: 4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21): 1.45 (0.92–2.31)/1.60 (1.27–2.02) for SGA; 0.90 (0.55–1.47)/1.05 (0.55–1.99) for LGA; 1.65 (1.08–2.51)/1.58 (1.28–1.96) for stunting; and 1.48 (1.02–2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value. Conclusion: The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes. Objective INTERGROWTH21st INTERGROWTHst INTERGROWTH 21st st IG . (IG21) Methods (BNRN VLBW (VLBW tertiarycare tertiary care hospitals Outcome (CNMM inhospital hospital death 4 enterocolitis smallforgestationalage small gestational age SGA (SGA rd SGA3 (SGA3 th SGA10 (SGA10 BW largeforgestationalage large LGA (LGA BMI logbinomial log binomial Results 4072 072 4,07 included BNRN/IG21 BNRNIG21 BNRNIG (BNRN/IG21) 145 1 45 1.4 0.92–2.31/1.60 092231160 0.92–2.31 /1.60 0 92 31 60 (0.92–2.31)/1.6 1.27–2.02 127202 27 02 (1.27–2.02 090 90 0.9 0.55–1.47/1.05 055147105 0.55–1.47 /1.05 55 47 05 (0.55–1.47)/1.0 0.55–1.99 055199 99 (0.55–1.99 165 65 1.6 1.08–2.51/1.58 108251158 1.08–2.51 /1.58 08 51 58 (1.08–2.51)/1.5 1.28–1.96 128196 28 96 (1.28–1.96 stunting 148 48 1.02–2.17 102217 17 (1.02–2.17 variable >95% 95 (>95% 7090%, 7090 70 90% , (70-90%) Conclusion IG2 outcomes (IG21 SGA1 (SGA1 407 07 4,0 BNRN/IG2 BNRNIG2 (BNRN/IG21 14 1. 0.92–2.31/1.6 09223116 092231 0.92–2.3 160 /1.6 9 6 (0.92–2.31)/1. 1.27–2.0 12720 (1.27–2.0 09 0. 0.55–1.47/1.0 05514710 055147 0.55–1.4 105 /1.0 5 (0.55–1.47)/1. 0.55–1.9 05519 (0.55–1.9 16 1.08–2.51/1.5 10825115 108251 1.08–2.5 158 /1.5 (1.08–2.51)/1. 1.28–1.9 12819 (1.28–1.9 1.02–2.1 10221 (1.02–2.1 >95 (>95 7090% 709 7 (70-90% (IG2 40 BNRN/IG (BNRN/IG2 0.92–2.31/1. 0922311 09223 0.92–2. /1. (0.92–2.31)/1 1.27–2. 1272 (1.27–2. 0.55–1.47/1. 0551471 05514 0.55–1. 10 (0.55–1.47)/1 0551 (0.55–1. 1.08–2.51/1. 1082511 10825 1.08–2. 15 (1.08–2.51)/1 1.28–1. 1281 (1.28–1. 1.02–2. 1022 (1.02–2. >9 (>9 (70-90 (IG (BNRN/IG 0.92–2.31/1 0922 0.92–2 /1 (0.92–2.31)/ 1.27–2 127 (1.27–2 0.55–1.47/1 0.55–1 (0.55–1.47)/ 055 (0.55–1 1.08–2.51/1 1082 1.08–2 (1.08–2.51)/ 1.28–1 128 (1.28–1 1.02–2 102 (1.02–2 (> (70-9 0.92–2.31/ 092 0.92– / (0.92–2.31) 1.27– 12 (1.27– 0.55–1.47/ 0.55– (0.55–1.47) (0.55– 1.08–2.51/ 108 1.08– (1.08–2.51) 1.28– (1.28– 1.02– (1.02– ( (70- 0.92 (0.92–2.31 1.27 (1.27 0.55 (0.55–1.47 (0.55 1.08 (1.08–2.51 1.28 (1.28 1.02 (1.02 (70 (0.92–2.3 1.2 (1.2 0.5 (0.55–1.4 (0.5 1.0 (1.08–2.5 (1.0 (7 (0.92–2. (1. (0. (1.08–2. (0.92–2 (1 (0 (1.08–2 (0.92– (1.08– (0.92 (1.08 (0.9

https://doi.org/10.1016/j.jped.2022.07.007

Posicionamento sobre Doença Isquêmica do Coração – A Mulher no Centro do Cuidado – 2023 202 20 2
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Oliveira, Gláucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Rassi, Daniela do Carmo

; Bragança, Érika Olivier Vilela

; Moura, Lidia Zytynski

; Arrais, Magaly

; Campos, Milena dos Santos Barros

; Lemke, Viviana Guzzo

; Avila, Walkiria Samuel

; Lucena, Alexandre Jorge Gomes de

; Almeida, André Luiz Cerqueira de

; Brandão, Andréa Araujo

; Ferreira, Andrea Dumsch de Aragon

; Biolo, Andreia

; Macedo, Ariane Vieira Scarlatelli

; Falcão, Breno de Alencar Araripe

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Marques-Santos, Celi

; Freire, Claudia Maria Vilas

; Pellegrini, Denise

; Alexandre, Elizabeth Regina Giunco

; Braga, Fabiana Goulart Marcondes

; Oliveira, Fabiana Michelle Feitosa de

; Cintra, Fatima Dumas

; Costa, Isabela Bispo Santos da Silva

; Silva, José Sérgio Nascimento

; Carreira, Lara Terra F.

; Magalhães, Lucelia Batista Neves Cunha

; Matos, Luciana Diniz Nagem Janot de

; Assad, Marcelo Heitor Vieira

; Barbosa, Marcia M.

; Silva, Marconi Gomes da

; Rivera, Maria Alayde Mendonça

; Izar, Maria Cristina de Oliveira

; Costa, Maria Elizabeth Navegantes Caetano

; Paiva, Maria Sanali Moura de Oliveira

; Castro, Marildes Luiza de

; Uellendahl, Marly

; Oliveira Junior, Mucio Tavares de

; Souza, Olga Ferreira de

; Costa, Ricardo Alves da

; Coutinho, Ricardo Quental

; Silva, Sheyla Cristina Tonheiro Ferro da

; Martins, Sílvia Marinho

; Brandão, Simone Cristina Soares

; Buglia, Susimeire

; Barbosa, Tatiana Maia Jorge de Ulhôa

; Nascimento, Thais Aguiar do

; Vieira, Thais

; Campagnucci, Valquíria Pelisser

; Chagas, Antonio Carlos Palandri

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 7 elocation e20230303

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230303

Image guidance for endoscopic sinus surgery: systematic review and meta-analysis surgery metaanalysis meta analysis
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Nobre, Maria Luísa

; Sarmento, Ayane Cristine Alves

; Bedaque, Henrique de Paula

; Medeiros, Kleyton Santos

; Cobucci, Ricardo Ney

; Diniz Júnior, José

; Gonçalves, Ana Katherine

Revista da Associação Médica Brasileira

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2023, Volume 69 Nº 10 elocation e20230633

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/1806-9282.20230633

Selection of entomopathogenic fungi to control stink bugs and cotton boll weevil1 weevil
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Sousa, Larissa Moreira de

; Quintela, Eliane Dias

; Boaventura, Heloiza Alves

; Silva, José Francisco Arruda e

; Tripode, Bruna Mendes Diniz

; Miranda, José Ednilson

Pesquisa Agropecuária Tropical

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2023, Volume 53 elocation e76316

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Entomopathogenic fungi stand out in the biological control of several agriculturally important insects. Six isolates of Metarhizium anisopliae, Cordyceps javanica, Beauveria sp. and B. bassiana were screened to control Anthonomus grandis, Euschistus heros, Oebalus poecilus, O. ypsilongriseus and Thyanta perditor, important insect pests of soybean, cotton and rice. The bioassays were conducted in a completely randomized design, with four replications (10 insects/replication). Significant differences for virulence were observed between the tested fungal species and isolates. For A. grandis, the most virulent isolate was M. anisopliae BRM 2335, followed by Beauveria BRM 14527 and BRM 67744 [82.5 to 97.5 % of mortality; average lethal time (LT50) of 5.9 to 7.8 days]. M. anisopliae BRM 2335 was also highly virulent to the four stink bug species (75 to 97.5 % of mortality; LT50 of 5.2 to 9.7 days). For the stink bugs, Beauveria sp. BRM 67744 was infectious to O. poecilus (75 % of mortality), but failed to control E. heros (16.9 % of mortality). C. javanica BRM 27666 and BRM 14526 showed average virulence to the stink bugs and A. grandis (17.5 to 57.3 % of mortality; LT50 of 6.0 to 9.7 days). M. anisopliae was consistently more virulent to the stink bugs than the other fungi. Therefore, M. anisopliae BRM 2335 was selected for further studies under screenhouse and field conditions to control A. grandis and other stink bug species, especially E. heros. insects sp B O perditor soybean rice design 10 (1 insects/replication. insectsreplication insects/replication . replication insects/replication) A M 1452 6774 82.5 825 82 5 [82. 975 97 97. mortality LT (LT50 59 9 5. 78 7 8 7. days. days days] 233 75 (7 LT5 52 2 9. days) mortality, , mortality) E 16.9 169 16 (16. mortality. C 2766 17.5 175 17 (17. 573 57 3 57. 60 6 0 6. Therefore 1 ( 145 677 82. [82 (LT5 23 16. (16 276 17. (17 14 67 [8 (LT 27 [

RESUMO Os fungos entomopatogênicos destacam-se no controle biológico de diversos insetos de importância agrícola. Seis isolados de Metarhizium anisopliae, Cordyceps javanica, Beauveria sp. e B. bassiana foram selecionados para o controle de Anthonomus grandis, Euschistus heros, Oebalus poecilus, O. ypsilongriseus e Thyanta perditor, importantes insetos-pragas da soja, algodão e arroz. Os bioensaios foram conduzidos em delineamento inteiramente casualizado, com quatro repetições (10 insetos/repetição). Foram observadas diferenças significativas, em termos de virulência, entre as espécies fúngicas e isolados testados. Para A. grandis, M. anisopliae BRM 2335 foi o isolado mais virulento, seguido por Beauveria BRM 14527 e BRM 67744 [82,5 a 97,5 % de mortalidade; tempo letal médio (TL50) de 5,9 a 7,8 dias]. M. anisopliae BRM 2335 também foi altamente virulento para as quatro espécies de percevejo (75 a 97,5 % de mortalidade; TL50 de 5,2 a 9,7 dias). Para os percevejos, Beauveria sp. BRM 67744 foi infeccioso para O. poecilus (75 % de mortalidade), mas falhou no controle de E. heros (16,9 % de mortalidade). C. javanica BRM 27666 e BRM 14526 apresentaram virulência mediana para os percevejos e A. grandis (17,5 a 57,3 % de mortalidade; TL50 de 6,0 a 9,7 dias). M. anisopliae foi consistentemente mais virulento aos percevejos do que os outros fungos. Portanto, M. anisopliae BRM 2335 foi selecionado para estudos posteriores em casa telada e campo para o controle de A. grandis e outras espécies de percevejo, principalmente E. heros. destacamse destacam se agrícola sp B O perditor insetospragas pragas soja arroz casualizado 10 (1 insetos/repetição. insetosrepetição insetos/repetição . repetição insetos/repetição) significativas testados A M 233 1452 6774 82,5 825 82 5 [82, 975 97 97, mortalidade TL (TL50 59 9 5, 78 7 8 7, dias. dias dias] 75 (7 TL5 52 2 9, dias) mortalidade, , mortalidade) E 16,9 169 16 (16, mortalidade. C 2766 17,5 175 17 (17, 573 57 3 57, 60 6 0 6, Portanto 1 ( 23 145 677 82, [82 (TL5 16, (16 276 17, (17 14 67 [8 (TL 27 [

https://doi.org/10.1590/1983-40632023v5376316

Epidemiological analysis of stroke patients with emphasis on access to acute-phase therapies
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ROSÁRIO, Camila Favoreto do

; FERNANDES NETO, Walker Garcia

; PESSOTTI, André Luiz

; RODRIGUES, Beatriz Cardoso

; BAPTISTA, Juliana Diniz

; SEGATTO, Marcela

; NUNES, Vinicius Santana

; BARBOSA, Leandro de Assis

; PEREIRA, Abraão Ferraz Alves

; MOTA, Christiane Lourenço

; FIOROT JÚNIOR, José Antônio

Arquivos de Neuro-Psiquiatria

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Fev 2022, Volume 80 Nº 2 Páginas 117 - 124

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Antecedentes: O acidente vascular cerebral (AVC) é um problema de saúde pública. Nos casos de AVC isquêmico, a trombólise venosa e a trombectomia mecânica são efetivas opções terapêuticas de fase aguda. Entretanto, mesmo com a Diretriz Nacional de AVC publicada desde 2012, o número de casos tratados ainda é baixo. Objetivo: Apurar os fatores determinantes para o acesso às terapias de fase aguda na realidade espírito-santense e investigar o perfil dos pacientes de AVC atendidos no Hospital Estadual Central de Vitória (HEC). Métodos: O presente estudo analisou dados retrospectivos de prontuários de 1.078 pacientes no período de maio de 2018 a dezembro de 2019. Resultados: Dos 1.078 pacientes, 54,9% eram homens e a faixa etária mais prevalente foi a de 60 a 79 anos. A hipertensão arterial sistêmica foi o principal fator de risco isolado. Quanto ao tratamento, identificou-se que entre os pacientes que chegaram ao HEC na janela terapêutica 47% receberam terapia de fase aguda e que acordar com o déficit foi a principal contraindicação para trombólise venosa nesses casos. Conclusões: As análises demonstraram que a aplicação do fluxograma estabelecido pela Secretaria de Estado da Saúde do Espírito Santo parece ser eficaz na agilidade de atendimento das vítimas de AVC e que o Serviço de Atendimento Móvel de Urgência tem um papel fundamental nesse processo. Além disso, a assistência de um centro terciário de AVC permite acesso às terapias de fase aguda com excelência. Todavia, mesmo que o modelo de serviço prestado no HEC seja eficiente, ele atinge no máximo 50% da população do ES, sendo necessária a sua ampliação.

ABSTRACT Background: Stroke is a public health problem. For patients with ischemic stroke, venous thrombolysis and mechanical thrombectomy are effective therapeutic options. However, even after the National Stroke Treatment Guidelines were published in 2012, the number of cases treated is still lower than expected. Objective: To identify the determining factors for obtaining access to acute-phase therapies in the state of Espírito Santo (ES) and investigate the profile of stroke patients treated at the Central State Hospital (HEC). Methods: Retrospective data from the medical records of 1078 patients from May 2018 to December 2019 were analyzed. Results: Among the 1,078 patients, 54.9% were men and the most prevalent age group was 60 to 79 years. Systemic arterial hypertension was the main single risk factor. Regarding treatment modality among the patients who arrived at the HEC within the therapeutic window, 47% received some type of acute-phase therapy. Waking up with the deficit was the main contraindication for venous thrombolysis in these cases. Conclusions: Application of the flowchart established by SESA-ES seemed to be effective for enabling responsiveness of care for stroke victims. Public emergency transport services had a fundamental role in this process. In addition, the care provided by the tertiary stroke center provided excellent access to acute-phase therapies. However, despite the efficiency of the service provided at the HEC, it only reached a maximum of 50% of the ES population. This service model therefore needs to be expanded throughout the state.

https://doi.org/10.1590/0004-282x-anp-2020-0466

Release of leachable products from resinous compounds in the saliva of children with anterior open bite treated with spur
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TOU, Gabriel Antônio dos Anjos

; GOMES, José Messias

; RINCO, Luiza Santana de Oliveira

; YAMAUTI, Mônica

; DINIZ, Ivana Márcia Alves

; PIRES, Fabiane

; SCHMIDT, Marcella Emilia Petra

; MENEZES, Helvécio Costa

; CARDEAL, Zenilda de Lourdes

; BOTTOLI, Carla Beatriz Grespan

; MACARI, Soraia

Journal of Applied Oral Science

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2022, Volume 30 elocation e20220227

Resumo: En | Texto: En | PDF: En

Abstract To evaluate the release of bisphenol-A glycidyl methacrylate (BisGMA), triethylene glycol dimethacrylate (TEGDMA), bisphenol A (BPA), and phthalates of the composite resin used in the bonding of spurs applied in the treatment of children with anterior open bite and its effects on human keratinocytes. Methodology Saliva samples of 22 children were collected before spur attachment (baseline) and 30 minutes (min) and 24 hours (h) after spur bonding. Analysis was performed using high-performance liquid chromatography (HPLC) coupled to tandem mass spectrometry (HPLC–MS/MS) and gas chromatography coupled to mass spectrometry (GC–MS). Standardized resin increments were added to three different dilutions of the cell culture medium. Keratinocytes (HaCaT) were cultivated in the conditioned media and evaluated for cell viability (MTT) and cell scratch assay. Results The levels of BisGMA (1.74±0.27 μg/mL), TEGDMA (2.29±0.36 μg/mL), and BPA (3.264±0.88 μg/L) in the saliva after 30 min, in comparison to baseline (0±0 μg/mL, 0±0 μg/mL, and 1.15±0.21 μg/L, respectively), presented higher numbers. After 24 h, the levels of the monomers were similar to the baseline. Phthalates showed no significant difference among groups. HaCat cells showed increased viability and reduced cell migration over time after exposure to methacrylate-based resin composites. Conclusion Resin composites, used to attach spurs in children with anterior open bite during orthodontic treatment, release monomers after polymerization and can influence the behavior of human keratinocytes, even at very low concentrations. Orthodontists should be aware of the risks of the resinous compounds release and preventive procedures should be held to reduce patient exposure. bisphenolA BisGMA, , (BisGMA) TEGDMA, (TEGDMA) BPA, (BPA) keratinocytes 2 (baseline 3 min (min h (h highperformance high performance HPLC (HPLC HPLC–MS/MS HPLCMSMS MS (HPLC–MS/MS GC–MS. GCMS GC–MS . GC (GC–MS) medium HaCaT (HaCaT MTT (MTT assay 1.74±0.27 174027 1 74 0 27 (1.74±0.2 μgmL μg/mL μg mL μg/mL) 2.29±0.36 229036 29 36 (2.29±0.3 3.264±0.88 3264088 264 88 (3.264±0.8 μg/L μgL L 00 (0± 0± 115021 15 21 1.15±0.2 respectively, respectively respectively) numbers groups methacrylatebased based composites concentrations (BisGMA (TEGDMA (BPA (GC–MS 1.74±0.2 17402 7 (1.74±0. 2.29±0.3 22903 (2.29±0. 3.264±0.8 326408 26 8 (3.264±0. (0 11502 1.15±0. 1.74±0. 1740 (1.74±0 2.29±0. 2290 (2.29±0 3.264±0. 32640 (3.264±0 ( 1150 1.15±0 1.74±0 174 (1.74± 2.29±0 229 (2.29± 3.264±0 3264 (3.264± 115 1.15± 1.74± 17 (1.74 2.29± (2.29 3.264± 326 (3.264 11 1.15 1.74 (1.7 2.29 (2.2 3.264 32 (3.26 1.1 1.7 (1. 2.2 (2. 3.26 (3.2 1. (1 2. (2 3.2 (3. 3. (3

https://doi.org/10.1590/1678-7757-2022-0227

10.

Oxidative damage associated with salt stress during germination and initial development of purple corn seedlings
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Alves, Rafael Mateus

; Silva, Monalisa Alves Diniz da

; Silva, Elania Freire da

; Hermínio, Pedro José

; Gomes-Junior, Francisco Guilhien

Acta Scientiarum. Agronomy

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2022, Volume 44 elocation e55760

Resumo: En | Texto: En | PDF: En

ABSTRACT. In various parts of the world, agricultural exploitation faces saline soil or water, such that cultivable species tend to be limited regarding the establishment of seedlings, with effects on productivity. The objective of this study was to evaluate the effects of salinity levels associated with different temperatures on the germination, initial development, and oxidative damage indicators of purple corn seedlings. The experiment was completely randomized in a 5 × 2 factorial design (moistening of the germination paper with 0, 25, 50, 75, and 100 mM NaCl solutions at temperatures of 25 and 30°C). The parameters evaluated were germination, growth, and oxidative damage indicators at the seedling phase. The germinative decline and initial development of purple corn seedlings, regardless of the temperature (25 and 30°C), reflected oxidative damage resulting from saline stress. Although deleterious effects of salinity were observed, a temperature of 30°C provided greater length and accumulation of dry mass of purple corn seedlings compared to the effects at 25°C. Total chlorophyll, chlorophyll a, chlorophyll b, total carotenoids, and lipid peroxidation, regardless of the temperature (25 and 30°C), were identified as sensitive biochemical indicators for the detection of physiological quality of purple corn seedlings subjected to NaCl.

https://doi.org/10.4025/actasciagron.v44i1.55760

11.

Antibacterial effect of isoeugenol against Pseudomonas aeruginosa
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Galvão, José Lucas Ferreira Marques

; Rosa, Lyvia Layanne Silva

; Diniz Neto, Hermes

; Silva, Daniele de Figueredo

; Nóbrega, Jefferson Rodrigues

; Cordeiro, Laísa Vilar

; Figueiredo, Pedro Thiago Ramalho de

; Andrade Júnior, Francisco Patricio de

; Oliveira Filho, Abrahão Alves de

; Lima, Edeltrudes de Oliveira

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e20075

Resumo: En | Texto: En | PDF: En

Abatsract Pseudomonas aeruginosa is an important nosocomial pathogen and its clinical importance is mainly related to nosocomial infections. Increased rates of bacterial resistance in recent years has led WHO to publish a global priority list to guide research and discovery of new antibiotics, where P. aeruginosa is among the group of bacteria for which there is a critical level of priority for new drugs to be discovered. In this context, isoeugenol appears as an interesting alternative and the objective of this study was to investigate its action against P. aeruginosa. Isoeugenol presented significant antibacterial activity, with minimum inhibitory concentration (MIC) of 64µg/mL and minimum bactericidal concentration (MBC) of 128µg/mL, and was considered bactericidal against this species. Molecular docking revealed interactions that suggest that isoeugenol may bind to the enzyme Penicillin-Binding Protein 3 and interfere with the bacterial cell wall synthesis process. This study reinforces the antibacterial potential of this compound and emphasizes that more studies are needed in order to better investigate its mechanism of antibacterial action.

https://doi.org/10.1590/s2175-97902022e20075

12.

Anemia and nutritional aspects in adolescent athletes: a cross-sectional study in a reference sport organization
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Capanema, Flávio Diniz

; Lamounier, Joel Alves

; Ribeiro, José Geraldo Leite

; Lima, Cláudio Olívio Vilela

; Paiva, Alan Rodrigues de Almeida

; Quadros, Patrícia Ribeiro

; Ferreira, Nádia Sachie Koyama

; Almeida, Tatiane Soares de

; Santos, Nicolly Carla Machado

Revista Paulista de Pediatria

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2022, Volume 40 elocation e2020350

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a associação entre anemia e aspectos nutricionais em atletas adolescentes de um clube desportivo de grande porte. Métodos: Trata-se de estudo de corte transversal que envolveu 298 atletas com idades entre 10 e 17 anos, submetidos à aferição de dobras cutâneas, peso e altura, além de coleta de sangue capilar em duplicata para a determinação dos valores de hemoglobina. Foi realizado em amostra aleatória composta de atletas oriundos de oito modalidades esportivas. Resultados: Em relação ao estado nutricional, 10,1% dos atletas apresentaram excesso de peso com base no índice de massa corpórea e 70 (23,5%) atletas estavam com porcentagem de gordura corporal classificada como alta ou muito alta. A prevalência de anemia foi de 16,4%, mais prevalente nos atletas do judô (37,1%), basquete (34%) e futsal (20,5%). Níveis baixos de hemoglobina foram associados à menor estatura (p=0,006). Conclusões: Observou-se associação significativa entre anemia e baixa estatura, o que sugere que o desenvolvimento pôndero-estatural do atleta pode ser afetado em condições subótimas de distribuição de oxigênio.

ABSTRACT Objective: To assess the association between anemia and nutritional aspects in adolescent athletes from a large sport club. Methods: This is a cross-sectional study, involving 298 athletes aged between 10 and 17 years, submitted to measurement of skin folds, weight and height, and collection of capillary blood in duplicate to determine hemoglobin values. It was carried out in a random sample composed of athletes from eight sport modalities. Results: Regarding nutritional status, 10.1% of athletes were overweight based on body mass index and 70 (23.5%) athletes had a percentage of body fat classified as high or very high. The prevalence of anemia was 16.4%, being more prevalent in judo (37.1%), basketball (34%) and futsal (20.5%) athletes. Low hemoglobin levels were significantly associated with shorter stature (p=0.006). Conclusions: There was a significant association between anemia and short stature, suggesting that the athlete's height-weight development may be affected in suboptimal conditions of oxygen distribution.

https://doi.org/10.1590/1984-0462/2022/40/2020350 265 downloads

13.

Guidelines on COVID-19 vaccination in patients with immune-mediated rheumatic diseases: a Brazilian Society of Rheumatology task force
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Tavares, Anna Carolina Faria Moreira Gomes

; Melo, Ana Karla Guedes de

; Cruz, Vítor Alves

; Souza, Viviane Angelina de

; Carvalho, Joana Starling de

; Machado, Ketty Lysie Libardi Lira

; Valadares, Lilian David de Azevedo

; Reis Neto, Edgard Torres dos

; Rezende, Rodrigo Poubel Vieira de

; Guimarães, Maria Fernanda Brandão de Resende

; Ferreira, Gilda Aparecida

; Braz, Alessandra de Sousa

; Vieira, Rejane Maria Rodrigues de Abreu

; Pinheiro, Marcelo de Medeiros

; Ribeiro, Sandra Lúcia Euzébio

; Bica, Blanca Elena Gomes Rios

; Baptista, Kátia Lino

; Costa, Izaias Pereira da

; Marques, Claudia Diniz Lopes

; Lopes, Maria Lúcia Lemos

; Martinez, José Eduardo

; Giorgi, Rina Dalva Neubarth

; Mota, Lícia Maria Henrique da

; Loures, Marcos Antônio Araújo da Rocha

; Paiva, Eduardo dos Santos

; Monticielo, Odirlei André

; Xavier, Ricardo Machado

; Kakehasi, Adriana Maria

; Pileggi, Gecilmara Cristina Salviato

Advances in Rheumatology

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2022, Volume 62 elocation 3

Resumo: En | Texto: En | PDF: En

Abstract Objective: To provide guidelines on the coronavirus disease 2019 (COVID-19) vaccination in patients with immune-mediated rheumatic diseases (IMRD) to rheumatologists considering specific scenarios of the daily practice based on the shared-making decision (SMD) process. Methods: A task force was constituted by 24 rheumatologists (panel members), with clinical and research expertise in immunizations and infectious diseases in immunocompromised patients, endorsed by the Brazilian Society of Rheumatology (BSR), to develop guidelines for COVID-19 vaccination in patients with IMRD. A consensus was built through the Delphi method and involved four rounds of anonymous voting, where five options were used to determine the level of agreement (LOA), based on the Likert Scale: (1) strongly disagree; (2) disagree, (3) neither agree nor disagree (neutral); (4) agree; and (5) strongly agree. Nineteen questions were addressed and discussed via teleconference to formulate the answers. In order to identify the relevant data on COVID-19 vaccines, a search with standardized descriptors and synonyms was performed on September 10th, 2021, of the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and LILACS to identify studies of interest. We used the Newcastle–Ottawa Scale to assess the quality of nonrandomized studies. Results: All the nineteen questions-answers (Q&A) were approved by the BSR Task Force with more than 80% of panelists voting options 4—agree—and 5—strongly agree—, and a consensus was reached. These Guidelines were focused in SMD on the most appropriate timing for IMRD patients to get vaccinated to reach the adequate covid-19 vaccination response. Conclusion: These guidelines were developed by a BSR Task Force with a high LOA among panelists, based on the literature review of published studies and expert opinion for COVID-19 vaccination in IMRD patients. Noteworthy, in the pandemic period, up to the time of the review and the consensus process for this document, high-quality evidence was scarce. Thus, it is not a substitute for clinical judgment.

https://doi.org/10.1186/s42358-022-00234-7

14.

Aluminium toxicity: oxidative stress during germination and early development in purple maize
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Alves, Rafael Mateus

; Silva, Monalisa Alves Diniz da

; Hermínio, Pedro José

; Silva, Elania Freire da

; Araújo, Anna Beatriz Nogueira de

; Silva, Gabriel Italo Novaes da

Revista Ciência Agronômica

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2022, Volume 53 elocation e20207676

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O milho roxo é fonte de pigmentos naturais que podem ser utilizados para diversas finalidades industriais, no entanto a contaminação dos solos por alumínio afeta sua produção. Diante do exposto, o objetivo foi avaliar o efeito da toxidez por alumínio associado a diferentes temperaturas sobre a germinação das sementes e desenvolvimento inicial de plântulas de milho roxo, por meio da germinação, crescimento inicial das plântulas e indicadores de danos oxidativos. O delineamento utilizado foi inteiramente casualizado, com esquema fatorial 5×2 (concentrações × temperaturas). Os parâmetros avaliados foram porcentagem de germinação, comprimento e massa seca total, da parte aérea, do sistema radicular e indicadores de danos oxidativos (clorofilas totais, a, b, carotenoides totais e peroxidação de lipídeos) na fase de plântula. As concentrações de cloreto de alumínio não interferem na germinação de sementes de milho roxo. O comprimento, massa seca, clorofilas totais, a, b e carotenoides totais das plântulas normais de milho roxo sofrem redução e acréscimos na peroxidação lipídica com o aumento das concentrações de alumínio. O estresse por toxidez do alumínio em plântulas de milho roxo é detectado pelos indicadores bioquímicos (clorofilas totais, a, b, carotenoides totais e peroxidação de lipídeos).

ABSTRACT Purple maize is a source of natural pigments that can be used for various industrial purposes; however, soil contamination from aluminium affects production. The aim of this study was to evaluate the effect of aluminium toxicity associated with different temperatures on seed germination and initial development in purple maize seedlings, through germination, initial seedling growth and indicators of oxidative damage. The experimental design was completely randomised in a 5×2 factorial scheme (concentrations × temperatures). The parameters under evaluation were germination percentage, length and total dry weight of the root system and shoots, and indicators of oxidative damage (chlorophyll a, chlorophyll b and total chlorophyll, total carotenoids and lipid peroxidation) at the seedling stage. Aluminium chloride concentrations have no effect on seed germination in purple maize. With increasing aluminium concentrations, the length, dry weight, chlorophyll a, chlorophyll b, total chlorophyll and total carotenoids of normal purple maize seedlings are reduced, while lipid peroxidation increases. Aluminium toxicity stress in purple maize seedlings can be detected using biochemical indicators (chlorophyll a, chlorophyll b and total chlorophyll, total carotenoids and lipid peroxidation).

https://doi.org/10.5935/1806-6690.20220039

15.

Chronic use of hydroxychloroquine did not protect against COVID-19 in a large cohort of patients with rheumatic diseases in Brazil
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Pileggi, Gecilmara Salviato

; Ferreira, Gilda Aparecida

; Gomides Reis, Ana Paula Monteiro

; Reis Neto, Edgard Torres

; Abreu, Mirhelen Mendes

; Albuquerque, Cleandro Pires

; Araújo, Nafice Costa

; Bacchiega, Ana Beatriz

; Bianchi, Dante Valdetaro

; Bica, Blanca

; Bonfa, Eloisa Duarte

; Borba, Eduardo Ferreira

; Brito, Danielle Christinne Soares Egypto

; Duarte, Ângela Luzia Branco Pinto

; Santo, Rafaela Cavalheiro Espírito

; Fernandes, Paula Reale

; Guimarães, Mariana Peixoto

; Gomes, Kirla Wagner Poti

; Kakehasi, Adriana Maria

; Klumb, Evandro Mendes

; Lanna, Cristina Costa Duarte

; Marques, Claudia Diniz Lopes

; Monticielo, Odirlei André

; Mota, Licia Maria Henrique

; Munhoz, Gabriela Araújo

; Paiva, Eduardo Santos

; Pereira, Helena Lucia Alves

; Provenza, José Roberto

; Ribeiro, Sandra Lucia Euzébio

; Rocha Junior, Laurindo Ferreira

; Sampaio, Camila Santana Justo Cintra

; Sampaio, Vanderson Souza

; Sato, Emília Inoue

; Skare, Thelma

; de Souza, Viviane Angelina

; Valim, Valeria

; Lacerda, Marcus Vinícius Guimarães

; Xavier, Ricardo Machado

; Pinheiro, Marcelo Medeiros

Advances in Rheumatology

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2021, Volume 61 elocation 60

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Abstract Background: There is a lack of information on the role of chronic use of hydroxychloroquine during the SARS-CoV-2 outbreak. Our aim was to compare the occurrence of COVID-19 between rheumatic disease patients on hydroxychloroquine with individuals from the same household not taking the drug during the first 8 weeks of community viral transmission in Brazil. Methods: This baseline cross-sectional analysis is part of a 24-week observational multi-center study involving 22 Brazilian academic outpatient centers. All information regarding COVID-19 symptoms, epidemiological, clinical, and demographic data were recorded on a specific web-based platform using telephone calls from physicians and medical students. COVID-19 was defined according to the Brazilian Ministry of Health (BMH) criteria. Mann-Whitney, Chi-square and Exact Fisher tests were used for statistical analysis and two binary Final Logistic Regression Model by Wald test were developed using a backward-stepwise method for the presence of COVID-19. Results: From March 29th to May 17st, 2020, a total of 10,443 participants were enrolled, including 5166 (53.9%) rheumatic disease patients, of whom 82.5% had systemic erythematosus lupus, 7.8% rheumatoid arthritis, 3.7% Sjögren’s syndrome and 0.8% systemic sclerosis. In total, 1822 (19.1%) participants reported flu symptoms within the 30 days prior to enrollment, of which 3.1% fulfilled the BMH criteria, but with no significant difference between rheumatic disease patients (4.03%) and controls (3.25%). After adjustments for multiple confounders, the main risk factor significantly associated with a COVID-19 diagnosis was lung disease (OR 1.63; 95% CI 1.03-2.58); and for rheumatic disease patients were diagnosis of systemic sclerosis (OR 2.8; 95% CI 1.19-6.63) and glucocorticoids above 10 mg/ day (OR 2.05; 95% CI 1.31-3.19). In addition, a recent influenza vaccination had a protective effect (OR 0.674; 95% CI 0.46-0.98). Conclusion: Patients with rheumatic disease on hydroxychloroquine presented a similar occurrence of COVID-19 to household cohabitants, suggesting a lack of any protective role against SARS-CoV-2 infection. Trial registration Brazilian Registry of Clinical Trials (ReBEC; RBR - 9KTWX6).

https://doi.org/10.1186/s42358-021-00217-0 22 downloads

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