ABSTRACT We sought to develop a typology describing structural, production, and socioeconomic characteristics of dairy systems that produce artisanal cheese and compare it with that of systems that produce only raw milk. Data on 204 raw milk producers and 58 artisanal cheese producers in Paraná State, Brazil, were collected through on-site surveys and subjected to descriptive analysis, factor analysis, and means tests. Descriptive analyses were applied to characterize the sample and artisanal cheese production processes. Factor analysis identified the following three typological components: system production capacity, herd breed and milking characteristics, and farmer social characteristics. Farmers were divided into two groups, as follows: non-cheese producers (NCP) and artisanal cheese producers (ACP). Groups of farmers were compared in terms of typological components. It was found that ACP have smaller structure and production scale and focus less on herd breed and practices for improving milk quality than NCP. These results suggest that artisanal cheese production is a strategy to add value to milk that does not meet institutional or market requirements for transactions with the dairy industry, providing a foothold for producers to remain in the dairy business. Groups of farmers (ACP and NCP) do not differ in social indicators of typology. structural 20 5 State Brazil onsite site tests processes components capacity groups follows noncheese non NCP (NCP ACP. . (ACP) industry business 2

RESUMO O desenvolvimento do sistema nervoso humano compõe uma série de eventos fundamentais e interdependentes envolvendo o nascimento, crescimento e maturação neuronal, além da seleção positiva ou negativa de sinapses desses neurônios que participarão da composição de circuitos neurais essenciais à atividade do sistema nervoso. Nesse contexto, em que o ambiente e as relações sociais parecem ser marcadores relevantes para o neurodesenvolvimento, técnicas avançadas de neuroimagem e ferramentas de avaliação comportamental têm demonstrado alterações em regiões cerebrais e funções cognitivas em crianças que se desenvolvem em ambientes de baixo ou alto nível socioeconômico. Considerando os aspectos mencionados, esta revisão teve como objetivo identificar a importância do status socioeconômico no desenvolvimento cerebral infantil, buscando identificar quais são os impactos desses fatores na formação morfológica e fisiológica do sistema nervoso, permitindo maior compreensão da importância dos fatores ambientais nos processos de neurodesenvolvimento. nascimento neuronal contexto neurodesenvolvimento mencionados infantil

ABSTRACT The development of the human nervous system makes up a series of fundamental and interdependent events involving birth, growth, and neuronal maturation, in addition to the positive or negative selection of synapses of these neurons that will participate in the composition of neural circuits essential to the activity of the nervous system. In this context, where environment and social relationships seem to be relevant markers for neurodevelopment, advanced neuroimaging techniques and behavioral assessment tools have demonstrated alterations in brain regions and cognitive functions among children developing in low or high socioeconomic status environments. Considering the aspects mentioned, this review aimed to identify the importance of socioeconomic status in children’s brain development, seeking to identify what are the impacts of these factors on the morphological and physiological formation of the nervous system, allowing a greater understanding of the importance of environmental factors in neurodevelopmental processes. birth growth maturation context neurodevelopment environments mentioned childrens s processes

RESUMO Neste trabalho avaliou-se numericamente a influência do módulo de elasticidade paralelo às fibras da madeira na estabilidade de arcos treliçados, considerando uma análise não linear geométrica baseada no Método dos Elementos Finitos (MEF). Essa abordagem foi realizada conforme uma formulação posicional do MEF, atribuindo-se os nós da estrutura como variáveis principais do sistema de equações não lineares, cuja resolução foi alcançada pelo método de Newton-Raphson. Ao todo, sete modelos de arco foram avaliados adotando-se madeiras coníferas e folhosas, com propriedades definidas segundo as classes de resistência da norma brasileira ABNT NBR 7190. Subrotinas foram desenvolvidas em linguagem MATLAB para resolução do sistema de equações não lineares e processamento da análise, incluindo a representação gráfica dos resultados e configurações do arco treliçado. Valores de esforços internos e deslocamentos foram determinados, assim como as forças de instabilidade dos arcos treliçados. Verificou-se que a força de instabilidade do arco constituído pela madeira folhosa mais rígida (D60) foi aproximadamente igual a 700% da força de instabilidade referente à classe conífera C20, e equivalente a 257,8% da força associada à classe folhosa D20. Concluiu-se que o módulo de elasticidade apresentou influência significativa no comportamento não linear geométrico do arco treliçado de madeira. Além disso, a análise não linear geométrica possibilitou o cálculo de parâmetros mais precisos e a verificação da estabilidade do sistema estrutural.

ABSTRACT In this work, it was numerically evaluated the influence of the modulus of elasticity parallel to the wood grain on the stability of trussed arches considering a nonlinear geometric analysis based on the Finite Element Method (FEM). This approach was carried out according to a positional formulation of the FEM, considering the structural nodes as main variables of the nonlinear equations system, whose resolution was obtained using the Newton-Raphson method. Altogether, seven arch models were evaluated, consisting of coniferous and hardwoods, with properties defined according to the strength classes of the Brazilian standard ABNT NBR 7190. The subroutines were written in MATLAB to solve the system of nonlinear equations and perform the analysis, including the graphical representation of the results and configurations of the trussed arch. Internal loads and displacements were obtained, in addition to the instability loads of the trussed arches. It was found that the instability load of the arch made with the stiffest hardwood (D60) was approximately equal to 700% of the instability load of the C20 coniferous class and equivalent to 257.8% of the D20 hardwood class-related load. It was verified that the modulus of elasticity significantly influences the nonlinear geometric behavior of the timber trussed arch. Furthermore, the nonlinear geometric analysis allowed calculating more accurate parameters and the verification of the stability of the structural system.

RESUMO. Considerando a variedade de mecanismos de contaminação pelo vírus Herpes simplex (HSV-1) e seu amplo potencial invasivo do sistema nervoso, uma infecção latente por toda a vida é estabelecida. Indivíduos adultos infectados podem ser suscetíveis à reativação viral quando estão sob a influência de múltiplos estressores, principalmente em pacientes imunocomprometidos. Esse fator orienta uma série de eventos neuroinflamatórios no córtex cerebral, culminando, raramente, em encefalite e edema cerebral citotóxico/vasogênico. Um somatório de estudos desses processos fornece uma explanação, embora ainda não totalmente esclarecida, de como a evolução clínica para déficit cognitivo e demência pode ser possibilitada. Além disso, é de extrema importância reconhecer o panorama mundial atual da demência e do déficit cognitivo. O objetivo da presente revisão de literatura é elucidar os dados disponíveis sobre a fisiopatologia da infecção pelo HSV-1, assim como descrever o panorama clínico das referidas afecções.

ABSTRACT. Considering the variety of mechanisms of Herpes simplex virus (HSV-1) contamination and its broad invasive potential of the nervous system, a life-long latent infection is established. Infected adult individuals may be susceptible to viral reactivation when under the influence of multiple stressors, especially regarding immunocompromised patients. This guides a series of neuroinflammatory events on the cerebral cortex, culminating, rarely, in encephalitis and cytotoxic / vasogenic brain edema. A sum of studies of such processes provides an explanation, even though not yet completely clarified, on how the clinical evolution to cognitive impairment and dementia might be enabled. In addition, it is of extreme importance to recognize the current dementia and cognitive deficit worldwide panorama. The aim of this literature review is to elucidate the available data upon the pathophysiology of HSV-1 infection as well as to describe the clinical panorama of the referred afflictions.

Abstract The giant otter (Pteronura brasiliensis) is an endangered mammal that occupies aquatic environments, especially in the Amazon Rainforest and Pantanal wetlands in South America. The species uses shelters (dens and campsites), such as burrowed tunnels and tangles of branches and roots along watercourses, where it feeds mainly on fishes. In Espírito Santo Creek (northern portion of the Pantanal wetlands in the state of Mato Grosso, Brazil), 60 shelters (45 dens and 15 campsites) were identified and georeferenced during 12 fieldtrips between 2002 and 2003. The density was 1.8 dens/km. The shelters were significantly found in locations with partial (35%) or complete (55%) plant cover. The dens were dug mainly in soil associated with roots located, on average, 4.4 m in distance and 2.4 m in height in relation to the waterline. The campsites had a significantly smaller distance and height compared to the dens. The greater density of dens in the study area underscores the need for conserved environments with little human interference for the protection of giant otter populations. The vegetal coverage of riparian forests and the occurrence of ravines along Espírito Santo Creek offer greater protection to the shelters, hindering the access of predators to the interior of the shelter. Studies integrating biological and ecological knowledge with social participation in areas of occurrence of the giant otter are fundamental to the conservation of the species and its habitat in the Pantanal wetlands of Mato Grosso, Brazil.

ABSTRACT This study aimed to investigate the influence of forage production area, concentrate supply, and farm labor on characterization of milk production systems (MPS) and their productive results. Milk volume data provided in 2014 by 110 dairy farms located in the eastern region of Santa Catarina State, Brazil, were obtained from a dairy industry. Forty-four farms with different production levels were selected, in which interviews were carried out aiming to characterize the management practices related to forage production area, concentrate supply, and farm labor. A principal component analysis (PCA) was performed. Then, regressions were made between the principal components (PC) and indicator variables of productive response (annual milk production, milk production per area, milk production per cow, milk production per worker on farm, and number of cows per hectare). Finally, we performed a hierarchical agglomerative cluster analysis based on the PCA, followed by comparison of the means between clusters. Three PC were generated: indicator of scale and intensification, indicator of age of the manager and his experience on dairy farming, and indicator of specialization and permanent family labor available. The three PC were influencing the production results, especially PC1. It was possible to form five clusters: cluster 1, characterized by the highest value in PC1, showed the highest production results, followed by the cluster 2, with intermediate values in PC1; clusters 3, 4, and 5, characterized by lower values in PC1 and distinguished by PC2 and PC3, had the lowest productive results. Aspects related to forage production area, concentrate supply, and workforce are important for MPS characterization and have significant influence on productive results.

ABSTRACT We aimed to compare the typology of dairy production systems (DPS) that meet Brazilian quality standards with that of non-compliant DPS. Semi-structured questionnaires were applied in 128 DPS located in Santa Izabel do Oeste, Paraná, Brazil (25°49'16" S and 53°29'04" W). In addition, milk quality reports of each DPS were analyzed. Dairy production systems were segregated into two groups: G1 – DPS that were in accordance with Brazilian regulations on milk quality, and G2 – DPS that did not comply with Brazilian regulations. Exploratory factor analysis was performed on structural, production, and technical variables. Two factors were defined: F1 – production scale and bargaining power, and F2 – autonomy and production control. Groups 1 and 2 were evaluated according to their structural, production, and technical characteristics as well as their F1 and F2 values. A small fraction (6.25%) of DPS met the minimum quality standards for milk. Dairy production systems that comply with quality regulations have larger production scale, higher productivity, and greater autonomy and control of milk production. Consequently, they have better bargaining power with the industry for the marketing of milk.

Resumo O artigo analisa a experiência de pessoas que vivem com a Síndrome de Berardinelli-Seip no Nordeste brasileiro. Este estudo qualitativo foi desenvolvido com onze interlocutores, sendo nove pessoas vivendo com a síndrome e duas mães. Para coligir as informações, utilizaram-se observação participante, caracterização social e entrevistas semiestruturadas. Os dados foram analisados por meio da técnica de codificação temática. Emergiram duas categorias: (1) ‘o segredo é fechar a boca’: gerenciamento da alimentação na vida cotidiana; e (2) ‘ah, é uma travesti?’ Corpo, gênero e masculinização. Concluiu-se que na experiência dos interlocutores seus agenciamentos e criatividade se traduziram em estratégias para gerenciamento da alimentação que integravam gostos, valores, hábitos, prescrições biomédicas e prazeres envolvidos em situações de comensalidade. No que tange à corporeidade, evidenciou-se que as representações e as experiências com o corpo apresentam desigualdades de gênero, na medida em que a mulher passa a ser alvo privilegiado de estigmas, preconceitos e discriminação na vida adulta.

Abstract This paper analyzes the experience of people living with the Berardinelli-Seip Syndrome in the Brazilian Northeast. This qualitative study was developed with eleven informants, namely, nine people living with the syndrome and two mothers. Information was gathered using participant observation, social characterization and semi-structured interviews. Data were analyzed by means of a thematic coding technique. Two categories emerged: (1) ‘the secret is to shut your mouth’: food management in daily life; and (2) ‘Ah, is it a transvestite?’ body, gender, and masculinization. We concluded that, in the experience of the informants, their negotiations and creativity translated into strategies for food management that integrated tastes, values, habits, biomedical prescriptions and pleasures involved in commensality situations. Regarding corporeality, it has been shown that representations and experiences with the body show gender inequalities, insofar as women become privileged targets of stigmas, prejudices and discrimination in adult life.

Resumo O artigo analisa a experiência de pessoas que vivem com a Síndrome de Berardinelli-Seip no Nordeste brasileiro. Este estudo qualitativo foi desenvolvido com onze interlocutores, sendo nove pessoas vivendo com a síndrome e duas mães. Para coligir as informações, utilizaram-se observação participante, caracterização social e entrevistas semiestruturadas. Os dados foram analisados por meio da técnica de codificação temática. Emergiram duas categorias: (1) ‘o segredo é fechar a boca’: gerenciamento da alimentação na vida cotidiana; e (2) ‘ah, é uma travesti?’ Corpo, gênero e masculinização. Concluiu-se que na experiência dos interlocutores seus agenciamentos e criatividade se traduziram em estratégias para gerenciamento da alimentação que integravam gostos, valores, hábitos, prescrições biomédicas e prazeres envolvidos em situações de comensalidade. No que tange à corporeidade, evidenciou-se que as representações e as experiências com o corpo apresentam desigualdades de gênero, na medida em que a mulher passa a ser alvo privilegiado de estigmas, preconceitos e discriminação na vida adulta.

Abstract This paper analyzes the experience of people living with the Berardinelli-Seip Syndrome in the Brazilian Northeast. This qualitative study was developed with eleven informants, namely, nine people living with the syndrome and two mothers. Information was gathered using participant observation, social characterization and semi-structured interviews. Data were analyzed by means of a thematic coding technique. Two categories emerged: (1) ‘the secret is to shut your mouth’: food management in daily life; and (2) ‘Ah, is it a transvestite?’ body, gender, and masculinization. We concluded that, in the experience of the informants, their negotiations and creativity translated into strategies for food management that integrated tastes, values, habits, biomedical prescriptions and pleasures involved in commensality situations. Regarding corporeality, it has been shown that representations and experiences with the body show gender inequalities, insofar as women become privileged targets of stigmas, prejudices and discrimination in adult life.

O objetivo definido neste trabalho foi verificar se produtores de leite que participam de arranjos horizontais (AH) possuem menor assimetria de informações, frente àqueles que não participam desses arranjos. Parte-se do pressuposto de que o maior acesso à informação resulta em menor risco para o produtor rural. Foram aplicados 120 questionários semiestruturados junto a produtores rurais de leite, localizados em quatro macrorregiões do Estado do Paraná. Foi realizada a análise fatorial exploratória (AFE) para definição de fatores relacionados à assimetria de informação em Sistemas Produtivos Leiteiros (SPL's). Os 120 produtores entrevistados foram divididos em dois grupos: aqueles que participavam de arranjos horizontais (AH) e aqueles que não participavam. Esses grupos foram confrontados com os fatores gerados na análise anterior. Foi encontrada diferença significativa (P<0,05) para os fatores "Informações relacionadas às transações" e "Informações globais para a atividade", sendo que produtores de leite que participavam de arranjos horizontais obtiveram melhores resultados. Por fim, conclui-se que produtores que participam de AH têm mais acesso à informação, o que pode criar um ambiente de menor assimetria de informações e consequentemente de menor risco, comparativamente a produtores que não participam de AH

An empirical investigation was conducted to study whether dairy farmers involved in horizontal arrangements (HA) have lower information asymmetry than those who do not participate in HA. Our assumption is that greater access to information results in fewer risky decisions in production systems. One hundred and twenty semi-structured questionnaires were applied to dairy farmers located in four different geographical regions in Paraná State, Brazil. Exploratory factor analysis was used to define factors related to information asymmetry in dairy agribusiness system (DAS) and four factors were defined. In a second step, the 120 dairy farmers were split into two groups: the first one involved in HA and the second one not involved in HA. Mean test (t-student) were performed to compare these groups between factors. Significant differences (P<0.05) were observed for factors related to transaction information and for general market information, and dairy farmers participating in HA achieved the greatest values. Finally, it can be concluded that dairy farmers who participate in HA have higher access to information, which can create an environment with lower information asymmetry and, consequently, be subject to lower risks than dairy farmers who do not participate in HA

The objective of this study was to evaluate the milk production, composition, milk fatty acid profile, butter texture and blood parameters of Holstein cows fed corn silage and concentrate containing one of the following: ground sunflower seeds; ground sunflower seeds treated with 50 g of lignosulfonate/kg of sunflower dry matter; pelleted sunflower seeds; or ground sunflower seeds pelleted and treated with 50 g of lignosulfonate/kg of sunflower dry matter. Four lactating cows were used, each with 130±28 days in lactation and a body weight of 569±63 kg. These animals were distributed in a Latin square design with four periods of 21 days each, with 14 days of adaptation and seven days of data collection. The diets were formulated to meet nutritional requirements and had a forage:concentrate ratio of 60:40. The milk fat was lower in the pelleted treatments. The concentrations of 16:1 n-11 and trans18:1 n-9 in the milk increased, and the n-6:n-3 ratio was higher for the pelleted treatments. The firmness and adhesiveness of the butter and the blood parameters analyzed were not affected by the treatments. Addition of lignosulfonate is not effective in protecting polyunsaturated fatty acids from the ruminal biohydrogenation process, and the pelleting process has little effect on the milk fatty acid profile and can not change the butter texture.

The objective of this study was to evaluate intake, in vitro and apparent digestibility and ruminal parameters of Holstein cows that were confined and fed corn silage and concentrate containing: ground sunflower seeds (GS); ground sunflower seeds treated with 5% lignosulfonate (GSL); pelleted sunflower seeds (PS); or ground and pelleted sunflower seeds treated with lignosulfonate (PSL). Four lactating cows with 130±28 days of lactation and body weights of 569±63 kg were used. These animals were distributed in a Latin square design with four diets and four periods of 21 days each. There were no differences in the intakes (% body weight) of dry matter (DM), organic matter (OM), mineral matter (MM), crude protein (CP), neutral detergent fiber (NDF) or acid detergent fiber (ADF). The apparent digestibility of DM, OM, CP, EE, NDF, ADF and NFC were similar for all the diets, with a tendency towards decreased CP digestibility for all the pelleted diets (65.79%) compared with the non-pelleted diets (69.66%). A negative effect of lignosulfonate was observed for the in vitro digestibility (IVD) of DM, and a negative tendency was observed for the IVD of OM. Pelleting decreased the concentration of acetic acid (55.95 × 58.82 mM) in rumen fluid. There was no effect of diet on pH (6.17) or ammonia nitrogen concentration (18.19 mg/dL). Pelleting and lignosulfonate do not promote the protective effect of sunflower seed nutrients as expected, and it may be more feasible to provide ground sunflower seed.

The objective of this study was to characterize and to analyze the room for manoeuvre in time in dairy production systems (DPS). Two interviews were conducted in twenty DPS in the Northern region of Paraná, Brazil, with the following objectives: to know the management and practices involving the herd, the land area and the commercialization; and to qualify and evaluate the work organization. In order to build the variables, the repertory grid method was used, and for the typology, the graphic methodology of Bertin adapted to small samples was used. The results showed that the room for manoeuvre in time of the DPS, quantified in hours available per year, varied between the farmers and was related to routine work and seasonal work durations, as well as the autonomy of farmers to perform both works. The routine work was related to the number of cows, but was also explained by the herd management, by the transport equipment for the feed and by the workforce composition. Four types of work organization were identified between sampled DPS, based on room for manoeuvre in time and how they were built. Knowing the room for manoeuvre time and its variables, it is possible to guide the farmers to adjust their dairy production system in order to have more time available for other activities or to develop the dairy production system.

Four multiparous Holstein cows averaging 548 kg of body weight and 74 d in lactation were used in a Latin square design with four 21-d experimental periods to determine effects of feeding extruded versus non-extruded canola seed, with or without 50 g/kg lignosulfonate on rumen fermentation, nutrient flow to the omasum, and degradability of dry matter (DM) and N of each diet. The DM effective degradability increased with extrusion and lignosulfonate treatment had no effect. The effective degradability of N was similar between diets. Lignosulfonate treatment of extruded versus non-extruded canola seeds decreased ruminal and total tract apparent digestibility of organic matter. The lowest apparent ruminal and highest intestinal digestibilities of protein, expressed as a percentage of N intake were observed for cows fed extruded canola seeds without lignosulfonate. Lignosulfonate treatment and extrusion had no effect on pH and concentrations of ammonia N and volatile fatty acids in the rumen. Results suggest that extruded canola seed untreated with formaldehyde may stimulate efficiency of microbial protein synthesis and is an effective means of increasing the availability of protein in the small intestine without affecting the total tract apparent digestibility of protein.

The objective of this study was to evaluate the administration of different doses of calcium hydroxide mixed with sugar cane fed to cows by the pH, ammonia nitrogen and volatile fatty acids concentration in ruminal content. Four cows with fistulated rumen were distributed in a Latin square (4 × 4) in split plot. The treatments involved adding doses of 0, 8, 16 and 24 g/kg of calcium hydroxide to sugar cane in natura. Samples of rumen fluid were collected and the pH and concentration of N-NH3 was determined before (time zero) and 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 hours after the feeding time. The concentration of volatile fatty acids at 0, 3, 6, 9 and 12 hours was also determined. The calcium hydroxide contributed to maintain the pH of rumen fluid close to neutral. The average concentrations of N-NH3 in the ruminal fluid was 20.59, 20.49, 17.28 and 18.22 mg/100 mL for samples with calcium hydroxide at 0, 8, 16, 24 g/kg, respectively. There was an effect of the addition of calcium hydroxide on the volatile fatty acids concentration from before feeding until 12 hours after feeding time. There was an effect on doses tested for the concentration of volatile fatty acids. The calcium hydroxide added to the sugar cane influences on ruminal parameters. The dose of approximately 10 g of calcium hydroxide per kg sugar cane in natura is recommended.