Abstract Background: Chronic Chagas cardiomyopathy (CCC) is caused by an inflammatory process induced by Trypanosoma cruzi, which leads to myocarditis with reactive and reparative fibrosis. CCC progresses with myocardial perfusion abnormalities and histopathological events that affect cardiorespiratory fitness (CRF). Objectives: We evaluated the effects of aerobic physical training (APT) on myocardial perfusion and on morphological and functional impairments related with inflammation and fibrosis in Syrian hamsters with CCC. As a secondary objective, we analyzed the cross-sectional areas of the skeletal muscle. Methods: Hamsters with CCC and their respective controls were divided into four groups: CCC sedentary, CCC-APT, sedentary control and APT control. Seven months after infection, the animals underwent echocardiography, myocardial perfusion scintigraphy and cardiopulmonary exercise testing. Moderate-intensity APT was performed for fifty minutes, five times a week, for eight weeks. Subsequently, the animals were reassessed. Histopathological analysis was conducted after the above-mentioned procedures. The level of significance was set at 5% in all analyses (p<0.05). Results: CCC sedentary animals presented worse myocardial perfusion defects (MPD) over time, reduced left ventricle ejection fraction (LVEF) and showed more inflammation and fibrosis when compared to other groups (mixed ANOVA analysis). Conversely, APT was able to mitigate the progression of MPD, ameliorate inflammation and fibrosis and improve CRF efficiency in CCC-APT animals. Conclusions: Our study demonstrated that APT ameliorated cardiac dysfunction, MPD, and reduced inflammation and fibrosis in CCC hamster models. Additionally, CCC-SED animals presented skeletal muscle atrophy while CCC-APT animals showed preserved skeletal muscle CSA. Understanding APT's effects on CCC's pathophysiological dimensions is crucial for future research and therapeutic interventions. Background (CCC cruzi CRF. . (CRF) Objectives (APT objective crosssectional cross sectional Methods CCCAPT, CCCAPT APT, infection echocardiography testing Moderateintensity Moderate intensity minutes week weeks Subsequently reassessed abovementioned above mentioned procedures 5 p<0.05. p005 p p<0.05 0 05 (p<0.05) Results MPD (MPD time LVEF (LVEF mixed analysis. analysis) Conversely Conclusions dysfunction models Additionally CCCSED SED CSA APTs s CCCs interventions (CRF p00 p<0.0 (p<0.05 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

Resumo Fundamento: A Cardiomiopatia Chagásica Crônica (CCC) é causada por um processo inflamatório induzido pelo Trypanosoma cruzi, que leva à miocardite com fibrose reativa e reparativa. A CCC progride com alterações de perfusão miocárdica e eventos histopatológicos que afetam a Aptidão Cardiorrespiratória (ACR). Objetivos: Avaliamos os efeitos do Treinamento Físico Aeróbico (TFA) na perfusão miocárdica e nos comprometimentos morfológicos e funcionais relacionados à inflamação e fibrose em hamsters sírios com CCC. Como objetivo secundário, analisamos as áreas de secção transversa do músculo esquelético. Métodos: Hamsters com CCC e seus respectivos controles foram divididos em quatro grupos: CCC sedentário, CCC-TFA, controle sedentário e controle TFA. Sete meses após a infecção, os animais foram submetidos à ecocardiografia, à cintilografia de perfusão miocárdica e ao teste de esforço cardiopulmonar. TFA de intensidade moderada foi realizado durante cinquenta minutos, cinco vezes por semana, por oito semanas. Posteriormente, os animais foram reavaliados. A análise histopatológica foi realizada após os procedimentos acima mencionados. O nível de significância foi estabelecido em 5% em todas as análises (p<0,05). Resultados: Animais com CCC sedentários apresentaram piores Defeitos de Perfusão Miocárdica (DPM) ao longo do tempo, Fração de Ejeção do Ventrículo Esquerdo (FEVE) reduzida, e apresentaram mais inflamação e fibrose quando comparados aos demais grupos (análise ANOVA mista). Por outro lado, o TFA foi capaz de mitigar a progressão do DPM, atenuar a inflamação e a fibrose e melhorar a eficiência da ACR em animais CCC-TFA. Conclusão: Nosso estudo demonstrou que o TFA melhorou a disfunção cardíaca, DPM e reduziu a inflamação e a fibrose em modelos de hamster com CCC. Além disso, os animais CCC-SED apresentaram atrofia do músculo esquelético, enquanto os animais CCC-TFA apresentaram a AST do músculo esquelético preservada. Compreender os efeitos da TFA nas dimensões fisiopatológicas da CCC é crucial para futuras pesquisas e intervenções terapêuticas. Fundamento (CCC cruzi reparativa ACR. . (ACR) Objetivos (TFA secundário Métodos CCCTFA, CCCTFA TFA, infecção ecocardiografia cardiopulmonar minutos semana semanas Posteriormente reavaliados mencionados 5 p<0,05. p005 p p<0,05 0 05 (p<0,05) Resultados (DPM tempo FEVE (FEVE reduzida mista. mista mista) lado CCCTFA. Conclusão cardíaca disso CCCSED SED preservada terapêuticas (ACR p00 p<0,0 (p<0,05 p0 p<0, (p<0,0 p<0 (p<0, p< (p<0 (p< (p

Abstract One of the crucial aspects to be considered for successful in vitro production (IVP) of embryos is the composition of the various media used throughout the stages of this reproductive biotechnology. The cell culture media employed should fulfill the metabolic requirements of both gametes during oocyte maturation and sperm development, as well as the embryo during its initial cell divisions. Most IVP protocols incorporate blood serum into the media composition as a source of hormones, proteins, growth factors, and nutrients. Numerous studies have suggested Platelet-Rich Plasma (PRP) as a substitute for fetal sera in cell culture, particularly for stem cells. Therefore, the objective of this study is to assess the potential use of PRP as a replacement for fetal bovine serum (FBS) during oocyte maturation for in vitro production of bovine embryos. During in vitro maturation (IVM), cumulus-oocyte complexes (COCs) were allocated into the following experimental groups: Group G1 (IVM medium with 5% PRP); Group G2 (MIV medium with 5% PRP and 5% SFB); Group G3 (MIV medium with 5% SFB); and Group G4 (MIV medium without either PRP or SFB). Subsequently, the cumulus-oocyte complexes were fertilized with semen from a single bull, and the resulting zygotes were cultured for seven days. Cleavage and blastocyst formation rates were assessed on days 2 and 7 of embryonic development, respectively. The quality of matured COCs was also evaluated by analyzing the gene expression of HSP70, an important protein associated with cellular stress. The results demonstrated that there were no significant differences among the experimental groups in terms of embryo production rates, both in the initial cleavage stages and blastocyst formation (except for the G4 group, which exhibited a lower blastocyst formation rate on D7, as expected). This indicates that PRP could be a cost-effective alternative to SFB in the IVP of embryos. (IVP biotechnology development divisions hormones proteins factors nutrients PlateletRich Platelet Rich (PRP cells Therefore FBS (FBS IVM, IVM , (IVM) cumulusoocyte cumulus (COCs G 5 PRP) MIV SFB) SFB. . Subsequently bull respectively HSP70 HSP stress except group D7 D expected. expected expected) costeffective cost effective HSP7

ABSTRACT Objective: To present the retrieval and analysis of clinical data from anamneses in the. Electronic Health Record (EHR), referred to in this research as Interface Terminology. Methods: The clinical data collection process in this research was carried out on electronic patient records from a private hospital. The data sample consisted of 18,256 anamneses from the field of gynecology in 2018. The clinical data was retrieved through Natural Language Processing using the Python language. The most frequent terms related to clinical data were analysed, such as abbreviations and acronyms, stop words, procedures, and n-grams. Results: Clinical data has the potential to be reused for scientific production, epidemiological profiling and in the creation of dictionaries and enrichment of controlled vocabularies for PEP and other health information systems. They are also important in defining algorithms for information retrieval. As a result, a repository was created in the OSF (https://osf.io/de43a/) containing spreadsheets and tables with clinical data for reuse in the delimitation of algorithms, as well as the creation of a word cloud to identify the most frequent terms in electronic patient records in the field of Gynecology. The algorithms used to retrieve the information were made available on the GitHub digital repository. Conclusions: Clinical data is information about the patient, used for care purposes, hospital administrative issues, allowing research related to the patient's health and illness. The Interface Terminology, exemplified in the research hospital's EHR, presented a diversity of clinical data in the anamneses. Objective EHR , (EHR) Terminology Methods 18256 18 256 18,25 2018 language analysed acronyms words procedures ngrams. ngrams n grams. grams n-grams Results production systems result https//osf.io/de43a/ httpsosfiode43a httpsosfiodea https //osf.io/de43a/ osf io de43a de (https://osf.io/de43a/ Gynecology Conclusions purposes issues patients s illness hospitals (EHR 1825 1 25 18,2 201 https//osf.io/de43a httpsosfiode osfiode43a osfiodea //osf.io/de43a dea (https://osf.io/de43a 182 2 18, 20 osfiode

RESUMO Objetivo: Apresentar a recuperação e análise de dados clínicos provenientes de anamnese de Prontuário Eletrônico de Pacientes (PEP), denominada nesta pesquisa como Terminologia de Interface Método: O processo de coleta de dados clínicos desta pesquisa foi realizado em prontuários eletrônicos de pacientes de hospital privado. A amostra dos dados foi composta por 18.256 anamneses do domínio da ginecologia do ano de 2018. Os dados clínicos foram recuperados por meio de Processamento de Linguagem Natural utilizando a linguagem Python. Foram analisados os termos mais frequentes relacionados aos dados clínicos do tipo: abreviaturas e siglas, stop words, procedimento e n-gramas. Resultados: Os dados clínicos têm potencial de reutilização para produção científica, traçar perfil epidemiológico e na criação de dicionários e enriquecimento de vocabulários controlados para o PEP e outros sistemas de informação em saúde. Além disso são importantes na delimitação de algoritmos para fins de recuperação da informação. Como resultados um repositório foi criado no OSF (https://osf.io/de43a/) contendo planilhas e tabelas com os dados clínicos para seu reuso na delimitação de algoritmos além da criação de nuvem de palavras para identificar os termos mais frequentes em prontuários eletrônicos do paciente no domínio da Ginecologia. Os algoritmos utilizados na recuperação da informação foram disponibilizados no repositório digital GitHub. Conclusões: Os dados clínicos são informações sobre o paciente, utilizados para fins de assistência, questões administrativas hospitalares, permitindo pesquisas relacionadas à saúde e à doença do paciente. A Terminologia de Interface, exemplificada no PEP dos Hospital da pesquisa, apresentou diversidade de dados clínicos nas anamneses. Objetivo PEP, , (PEP) Método privado 18256 18 256 18.25 2018 Python tipo siglas words ngramas. ngramas n gramas. gramas n-gramas Resultados científica https//osf.io/de43a/ httpsosfiode43a httpsosfiodea https //osf.io/de43a/ osf io de43a (https://osf.io/de43a/ Ginecologia GitHub Conclusões assistência hospitalares (PEP 1825 1 25 18.2 201 https//osf.io/de43a httpsosfiode osfiode43a osfiodea //osf.io/de43a dea (https://osf.io/de43a 182 2 18. 20 osfiode

Abstract Concrete presents complex behavior, being a difficult material to define the ideal proportion of its constituents. To overcome this challenge, many mix design methods have been developed over time. However, most of these methods do not consider durability parameters during the procedure. Thus, the objective of this article is to present a mix design method for concrete, with properties of workability (slump rating from 50 mm to 220 mm), axial compressive strength (class of 25MPa to 55MPa), and durability as response parameters. From the application of the proposed method, it was possible to create mix design and performance diagrams. It was noticed that all concretes fell into the pre-established consistency class and presented axial compressive strength results close to the predetermined values. Moreover, it was possible to obtain indications of the material's durability. behavior constituents challenge time However procedure Thus concrete slump 5 22 mm, , mm) MPa 55MPa, 55MPa 55MPa) diagrams preestablished pre established values Moreover materials s 2

Resumo O concreto apresenta um comportamento complexo, sendo uma atividade difícil definir a proporção ideal dos seus constituintes. A fim de superar esse desafio, muitos métodos de dosagem foram desenvolvidos, ao longo do tempo. Entretanto, a maioria desses métodos não considera parâmetros de durabilidade durante o procedimento. Assim, o objetivo deste artigo é apresentar um método para dosar concretos, tendo como parâmetros de resposta propriedades de trabalhabilidade (valores de abatimento de 50 mm a 220 mm), de resistência à compressão axial (classe de 25MPa a 55MPa) e de durabilidade. A partir da aplicação do método proposto, foi possível elaborar os diagramas de dosagem e de desempenho. Percebeu-se que todos os concretos se enquadraram na classe de consistência pré-estabelecida e apresentaram resultados de resistência à compressão axial próximos aos valores pré-determinados. Além disso, foi possível obter indicativos da durabilidade do material. complexo constituintes desafio desenvolvidos tempo Entretanto procedimento Assim 5 22 mm, , mm) MPa 55MPa proposto desempenho Percebeuse Percebeu préestabelecida pré estabelecida prédeterminados. prédeterminados determinados. determinados pré-determinados disso material 2

Abstract Introduction Jet aircraft pilots are exposed to huge pressure variation during flight, which affect physiological functions as systems, such as the respiratory system. Objectives The objective of the present investigation was to evaluate inflammatory changes of paranasal sinuses of jet aircraft pilots before and after a jet aircraft training program, using multislice computed tomography (CT), in comparison with a group of nonairborne individuals with the same age, sex, and physical health conditions. A second objective of the present study was to assess the association between the ostiomeatal complex obstruction and its anatomical variations. Methods The study group consisted of 15 jet aircraft pilots participating in the training program. The control group consisted of 41 nonairborne young adults. The 15 fighter pilots were evaluated before initiating the training program and after their final approval for the presence of inflammatory paranasal sinus disease. The ostiomeatal complex anatomical variations and obstructions were analyzed in pilots after the training program. Results Jet aircraft pilots presented higher incidence of mucosal thickening in maxillary sinus and anterior ethmoid cells than controls. Prominent ethmoidal bulla showed significant association with obstruction of the osteomeatal complex. Conclusions Jet aircraft pilots present increased inflammatory disease when compared with nonairborne individuals. The presence of a prominent ethmoidal bulla is associated with ostiomeatal complex obstruction. flight systems system CT, CT , (CT) age sex conditions 1 4 adults controls (CT

Abstract In reproductive technologies, uncovering the molecular aspects of oocyte and embryo competence under different conditions is crucial for refining protocols and enhancing efficiency. RNA-seq generates high-throughput data and provides transcriptomes that can undergo additional computational analyses. This study presented the transcriptomic profiles of in vitro matured oocytes and blastocysts produced in vitro from buffalo crossbred (Bubalus bubalis), coupled with gene co-expression and module preservation analysis. Cumulus Oophorus Complexes, obtained from slaughterhouse-derived ovaries, were subjected to in vitro maturation to yield metaphase II oocytes (616) or followed in vitro fertilization and culture to yield blastocysts for sequencing (526). Oocyte maturation (72%, ±3.34 sd) and embryo development (21.3%, ±4.18 sd) rates were obtained from three in vitro embryo production routines following standard protocols. Sequencing of 410 metaphase II oocytes and 70 hatched blastocysts (grade 1 and 2) identified a total of 13,976 genes, with 62% being ubiquitously expressed (8,649). Among them, the differentially expressed genes (4,153) and the strongly variable genes with the higher expression (fold-change above 11) were highlighted in oocytes (BMP15, UCHL1, WEE1, NLRPs, KPNA7, ZP2, and ZP4) and blastocysts (APOA1, KRT18, ANXA2, S100A14, SLC34A2, PRSS8 and ANXA2) as representative indicators of molecular quality. Additionally, genes exclusively found in oocytes (224) and blastocysts (2,200) with specific biological functions were identified. Gene co-expression network and module preservation analysis revealed strong preservation of functional modules related to exosome components, steroid metabolism, cell proliferation, and morphogenesis. However, cell cycle and amino acid transport modules exhibited weak preservation, which may reflect differences in embryo development kinetics and the activation of cell signaling pathways between buffalo and bovine. This comprehensive transcriptomic profile serves as a valuable resource for assessing the molecular quality of buffalo oocytes and embryos in future in vitro embryo production assays. technologies efficiency RNAseq RNA seq highthroughput high throughput analyses Bubalus bubalis, bubalis , bubalis) coexpression co Complexes slaughterhousederived slaughterhouse derived ovaries 616 (616 526. 526 . (526) 72%, 72 (72% 334 3 34 ±3.3 sd 21.3%, 213 21 (21.3% 418 4 18 ±4.1 41 7 grade 2 13976 13 976 13,97 62 8,649. 8649 8,649 8 649 (8,649) them 4,153 4153 153 (4,153 foldchange fold change 11 BMP15, BMP15 BMP (BMP15 UCHL1 UCHL WEE1 WEE NLRPs KPNA7 KPNA ZP2 ZP ZP4 APOA1, APOA1 APOA (APOA1 KRT18 KRT ANXA2 ANXA S100A14 SA S A SLC34A2 SLCA SLC PRSS Additionally 224 (224 2,200 2200 200 (2,200 components metabolism proliferation morphogenesis However bovine assays 61 (61 52 (526 72% (72 33 ±3. 21.3% (21.3 ±4. 1397 97 13,9 6 864 8,64 64 (8,649 4,15 415 15 (4,15 BMP1 (BMP1 (APOA KRT1 S100A1 SLC34A 22 (22 2,20 220 20 (2,20 (6 5 (52 (7 ±3 21.3 (21. ±4 139 9 13, 86 8,6 (8,64 4,1 (4,1 (BMP S100A (2 2,2 (2,2 ( (5 ± 21. (21 8, (8,6 4, (4, 2, (2, (8, (4 (8

Abstract This study aims to evaluate the phytochemical properties of Bauhinia holophylla (Bong.) Steud leaf extract, and their impact on maternal reproductive and fetal development in diabetic rats. For this, adult female Wistar rats (100 days of life) received streptozotocin (40 mg/Kg, intraperitoneal) for induction of diabetes, were mated and distributed into four groups: Nondiabetic; Nondiabetic given B. holophylla; Diabetic; and Diabetic given B. holophylla. The plant extract was given by gavage at increasing doses: 200, 400, and 800 mg/Kg. At day 21 of pregnancy, liver and blood samples were obtained for oxidative parameters and biochemical analysis, respectively. The uterus was removed for maternal-fetal outcomes. Phytochemical analysis showed a high content of phenolic components and biogenic amines. B. holophylla extract did not alter the glycemic levels but improved the lipid profile in diabetic animals. Besides that, the number of live fetuses and maternal weight gain were decreased in Diabetic group, and were not observed in animals treated. The group Diabetic treated presented a higher percentage of fetuses classified as adequate for gestational age compared to the Diabetic group. However, the treatment with plant extract caused embryo losses, fetal growth restriction, and teratogenicity in nondiabetic rats. Thus, the indiscriminate consumption requires carefulness. Bong. Bong (Bong. this 100 (10 life 40 (4 mgKg mg Kg mg/Kg intraperitoneal diabetes groups B doses 200 400 80 2 pregnancy respectively maternalfetal outcomes amines that However losses restriction Thus carefulness (Bong 10 (1 4 ( 20 8 1

Abstract Robotic milking systems are successful innovations in the development of dairy cattle. The objective of this study was to analyse the milking characteristics and behavior of dairy cows of different calving orders in “milk first” robotic milking systems. The data were collected from a commercial herd located in the Midwest region of Minas Gerais (Brazil), which uses an automatic milking system (AMS TM, DeLaval). Were analysed 26,574 observations of 235 Holstein cows were available. Data were evaluated by multivariate analysis of variance and the Tukey test. - Tthe characteristics milk flow and milking efficiency were more favourable for multiparous cows (p <0.01), while the time in the stall was more favourable for primiparous females (p <0.01). The values of handling time were better in the primiparous cows (p <0.01). Primiparous cows had higher amounts of kick-off (p <0.001), and multiparous cows had higher incomplete milkings (p <0.001). The number of incomplete milkings showed a higher ratio in terms of reduction in milk production in 26.6% in primiparous cows and 26.7% in multiparous cows (p <0.01). Regarding the behavioral characteristics, primiparous cows had higher amounts of kickbacks, while multiparous cows had greater quantities of incomplete milkings. cattle first Brazil, Brazil , (Brazil) AMS TM DeLaval. DeLaval . DeLaval) 26574 26 574 26,57 23 available test p <0.01, 001 <0.01 0 01 <0.01) <0.01. kickoff kick off <0.001, 0001 <0.001 <0.001) <0.001. 266 6 26.6 267 7 26.7 kickbacks (Brazil 2657 2 57 26,5 00 <0.0 000 <0.00 26. 265 5 26, <0. <0 <

Abstract There is a gap between high-income countries and others in terms of access to medical cardiac devices, such as pacemakers and implantable cardioverter defibrillators. Costs are one of the main barriers to the use of cardiac devices in these countries. There are international initiatives that aim to reduce the gap. The reuse of pacemakers has been discussed as a possible alternative to this problem. The concept of reusing pacemakers is not new; however, recent studies have proven to be safe, ethical, and effective for those who need cardiac implantable electronic devices and cannot afford them. Part of the Portuguese-speaking countries, especially in Africa, need an immediate response that benefits their countless patients who suffer from treatable arrhythmias. highincome high income defibrillators problem new however safe ethical them Portuguesespeaking Portuguese speaking Africa arrhythmias

Resumo Há uma enorme disparidade entre os países de alta renda e outros em termos de acesso a dispositivos médicos cardíacos, como marca-passos e desfibriladores implantáveis. Os custos são uma das principais barreiras ao uso de dispositivos cardíacos nesses países. Existem iniciativas internacionais que visam reduzir essa disparidade, e o reuso de marca-passos tem sido discutido como uma possível alternativa. O conceito de reutilização de marca-passos não é novo; entretanto, estudos recentes têm se mostrado seguros, éticos e eficazes para aqueles que precisam de dispositivos eletrônicos cardíacos implantáveis e não tem como adquiri-los. Parte dos países de língua portuguesa, especialmente na África, precisam de uma resposta imediata que beneficie seus inúmeros pacientes que sofrem de arritmias tratáveis. marcapassos marca passos alternativa novo entretanto seguros adquirilos. adquirilos adquiri los. los adquiri-los portuguesa África tratáveis

Abstract In Compost-Bedded Pack Barn (CBP) systems, air velocity is linked with the thermal comfort of housed dairy cattle and bedding quality and, therefore, assessing ventilation efficiency is essential. In this context, the objective of this study was to evaluate and characterize dependence and spatial distribution of air velocity at the 1.5 m height (vair,M) and at bedding level (vair,B) in an open CBP system with positive pressure ventilation. The study was conducted in 2021, in a facility located in the Zona da Mata region, Minas Gerais, Brazil. The facility area was divided into a mesh composed of 55 equidistant points, where vair,M and vair,B data were collected in the morning (09:00 a.m.) and afternoon (03:00 p.m.) periods, during three weeks in Brazilian winter. Geostatistics techniques were used to assess dependence and spatial distribution. In both periods evaluated, there were a strong occurrence of spatial dependence and non-uniform vair,M and vair,B distributions. The vair,M and vair,B values were lower than recommended (1.8 m∙s–1) in more than 65.0% of the area. Adequate ventilation levels were observed only in the first 20.0 m of the facility, from Southeast to Northwest, because of the fan lines present. CompostBedded Compost Bedded (CBP systems therefore essential context 15 1 5 1. vairM vair M (vair,M vairB B (vair,B 2021 region Gerais Brazil points 0900 09 00 (09:0 a.m. am 0300 03 (03:0 p.m. pm p winter evaluated nonuniform non uniform distributions 1.8 18 8 (1. m∙s–1 ms1 ms s 650 65 0 65.0 200 20 20. Northwest present 202 090 (09: a.m 030 (03: p.m (1 m∙s– 6 65. 2 (09 (03 ( m∙s (0

ABSTRACT Purpose To demonstrate the epidemiological profile and risk factors of patients with age-related macular degeneration (ARMD). Methods Observational and sectional study. One eye of each patient with greater visual impairment due to AMD treated at the University Hospital Antônio Pedro was included. The main variable to be compared was the presence of AMD divided into inexpressive, initial, intermediate, and advanced stages, according to the classification of the AREDS study. The secondary variables were demographics (gender, age, race, age group), body mass index, iris color, family history of ARMD, lens status, long-term exposure to ultraviolet light and smoking. Statistical tests were performed with Kruskal-Wallis and Chi-square analyses and Student’s t test. The significance level was set at 5%. Results After the inclusion and exclusion criteria, 126 patients were included in this study, 20 patients with non-expressive AMD, 30 patients with early AMD, 30 patients with intermediate AMD, and 46 patients with advanced AMD. Among all the risk factors surveyed, only smoking was statistically significant (p = 0.03). Conclusion Smoking as a risk factor for AMD had significant relevance prevalent in this research and even as a preventive factor for this ocular morbidity. agerelated related ARMD. ARMD . (ARMD) study inexpressive initial stages gender, gender (gender race group, group , group) index color status longterm long term KruskalWallis Kruskal Wallis Chisquare Chi square Students Student s test 5 5% criteria 12 2 nonexpressive non expressive 3 4 surveyed p 0.03. 003 0.03 0 03 0.03) morbidity (ARMD 1 00 0.0 0.

RESUMO Objetivo Demonstrar o perfil epidemiológico e fatores de riscos de pacientes com degeneração macular relacionada à idade. Métodos Estudo observacional e seccional. Foi incluído um olho de cada paciente com maior comprometimento visual por degeneração macular relacionada à idade atendido no Hospital Universitário Antônio Pedro. A variável principal a ser comparada foi a presença de degeneração macular relacionada à idade dividida nos estágios inexpressivo, inicial, intermediário e avançado, segundo classificação do estudo AREDS. As variáveis secundárias foram os dados demográficos (sexo, idade, raça, faixa etária), índice de massa corporal, cor da íris, história familiar de degeneração macular relacionada à idade, status do cristalino, longo tempo exposição à luz ultravioleta e tabagismo. Foram realizados testes estatísticos com análise de Kruskal-Wallis, do teste do qui-quadrado e teste t de Student. O nível de significância foi definido em 5%. Resultados Após os critérios de inclusão e exclusão, 126 pacientes foram incluídos neste estudo, sendo 20 pacientes com degeneração macular relacionada à idade inexpressiva, 30 pacientes com degeneração macular relacionada à idade inicial, 30 pacientes com degeneração macular relacionada à idade intermediária e 46 pacientes com degeneração macular relacionada à idade avançada. Dentre todos os fatores de risco pesquisados, apenas o tabagismo se mostrou estatisticamente significativo (p=0,03). Conclusão O tabagismo como fator de risco para degeneração macular relacionada à idade apresentou ter importância expressiva prevalente nesta pesquisa e até mesmo como fator preventivo dessa morbidade ocular. seccional Pedro inexpressivo inicial avançado AREDS sexo, sexo (sexo raça etária, etária , etária) corporal íris cristalino KruskalWallis, KruskalWallis Kruskal Wallis, Wallis Kruskal-Wallis quiquadrado qui quadrado Student 5 5% exclusão 12 2 inexpressiva 3 4 avançada pesquisados p=0,03. p003 p p=0,03 . 0 03 (p=0,03) ocular 1 p00 p=0,0 (p=0,03 p0 p=0, (p=0,0 p=0 (p=0, p= (p=0 (p= (p

RESUMEN Objetivo: Analizar la asociación entre la calidad de vida y el consumo de sustancias psicoactivas en estudiantes de ascendencia africana. Método: Investigación epidemiológica, descriptiva, comparativa y transversal realizada entre agosto y noviembre de 2017, con personas adolescentes matriculadas en una escuela afrobrasileña, ubicada en la región nordeste. El procedimiento de muestreo adoptado fue aleatorio simple. Para la recolección de datos se utilizó un formulario sociodemográfico; una encuesta sobre calidad de vida (WHOQOL-bref) y otra sobre consumo de sustancias psicoactivas (DUSI - Drug Use Screening Inventory). Se utilizó la prueba no paramétrica U de Mann-Whitney para comparar los grupos. Resultados: La muestra estuvo constituida por 203 estudiantes, de quienes 123 (60.3 %) eran del sexo femenino, 108 (53.2%) tenían entre 16 y 19 años y 157 se autodescribieron como personas negras (77.3%). En cuanto al consumo de drogas, 101 (49.8%) adolescentes reportaron consumir al menos una droga lícita o ilegal. El alcohol fue la droga más consumida, totalizando 88 estudiantes. Las personas adolescentes que relataron el uso de sustancias psicoactivas en el último mes presentaron menor puntaje de calidad de vida en los dominios físico (p<0.05), psicológico (p<0.05) y ambiental (p<0.05). Conclusión: El consumo de sustancias lícitas e ilícitas demostró ser un punto de gran importancia para la calidad de vida de la población adolescente de ascendencia africana y la percepción de aspectos relacionados con el contexto en que se insertan.

RESUMO Objetivo: analisar a associação entre Qualidade de Vida e consumo de substâncias psicoativas em alunos de ancestralidade do continente africano. Método: pesquisa epidemiológica, descritiva, comparativa e de delineamento transversal, realizada entre os meses de agosto e novembro de 2017, com adolescentes matriculados em uma escola afro-brasileira localizada na região nordeste. O procedimento amostral adotado foi o aleatório simples. Para a coleta de dados, foi utilizado formulário sociodemográfico; um inquérito sobre Qualidade de Vida (WHOQOL-bref) e outro sobre consumo de substâncias psicoativas (DUSI - Drug Use Screening Inventory). O teste U de Mann-Whitney não paramétrico foi usado para comparar os grupos. Resultados: a mostra foi composta por 203 escolares, destes, 123 (60,3%) eram do sexo feminino, 108 (53,2%) estavam na faixa etária de 16 a 19 anos e 157 declaravam-se negros (77,3%). Já para o uso de drogas, 101 (49,8%) adolescentes relataram usar ao menos uma droga lícita ou ilegal. O álcool foi a droga mais usada, total de 88 estudantes. Os adolescentes que relatam uso de substâncias psicoativas no último mês apresentaram menor escore de Qualidade de Vida em nossos domínios físico (p<0,05), psicológico (p<0,05) e ambiental (p<0,05). Conclusão: o consumo de substâncias lícitas e ilícitas mostrou-se como um ponto de grande importância para a qualidade de vida dos adolescentes de ancestralidade do continente africano e para a percepção de aspectos relacionados ao contexto que estão inseridos.

ABSTRACT Objective: to analyze the relationship between Quality of Life and consumption of psychoactive substances in the students of African Continental Ancestry Groups. Method: this was an epidemiological, descriptive, comparative, and cross-sectional study carried out between August and November 2017 with adolescents enrolled in an Afro-Brazilian school in the northeast region. A simple random sampling procedure was adopted. For the data collection, the following instruments were used: a sociodemographic questionnaire, a survey on the Quality of Life (WHOQOL-bref), and a survey about consumption of psychoactive substances (DUSI - Drug Use Screening Inventory). The nonparametric Mann-Whitney U test was used to compare the groups. Results: the population consisted of 203 students; 123 (60.3%) of them were female; 108 (53.2%) were aged between 16 and 19 years old, and 157 (77.3%) considered themselves black. As for drug use, 101 (49.8%) adolescents reported to have used at least one licit or illegal drug. Alcohol was the most used drug (88 students in total). The adolescents who reported using psychoactive substances in the last month had a lower Quality of Life score in the physical (p<0,05), psychological (p<0,05), and environmental domains (p<0,05). Conclusion: the consumption of licit and illicit substances proved to be a point of great importance for the quality of life of adolescents of African ancestry and the perception of aspects related to the context in which they are inserted.

RESUMO As Diretrizes Brasileiras para Reabilitação do AVC são fruto de um esforço conjunto do Departamento Científico de Reabilitação Neurológica da Academia Brasileira de Neurologia com o objetivo de orientar os profissionais envolvidos no processo de reabilitação para a redução da incapacidade funcional e aumento da autonomia dos indivíduos. Membros do grupo acima participaram de fóruns de discussão na web com pré-temas, seguidos de reuniões por videoconferência em que as controvérsias foram discutidas, levando a um consenso. Essas diretrizes, divididas em duas partes, focam as implicações de recentes ensaios clínicos, revisões sistemáticas e metanálises sobre reabilitação do AVC. O objetivo principal é servir de orientação a médicos, fisioterapeutas, fonoaudiólogos, terapeutas ocupacionais, enfermeiros, nutricionistas e demais profissionais envolvidos no cuidado pós-AVC. As recomendações e níveis de evidência foram adaptados de acordo com a literatura disponível atualmente. Aqui é apresentada a Parte I sobre tópicos de reabilitação na fase aguda, prevenção e tratamento de doenças e comorbidades frequentes após o AVC.

ABSTRACT The Guidelines for Stroke Rehabilitation are the result of a joint effort by the Scientific Department of Neurological Rehabilitation of the Brazilian Academy of Neurology aiming to guide professionals involved in the rehabilitation process to reduce functional disability and increase individual autonomy. Members of the group participated in web discussion forums with predefined themes, followed by videoconference meetings in which issues were discussed, leading to a consensus. These guidelines, divided into two parts, focus on the implications of recent clinical trials, systematic reviews, and meta-analyses in stroke rehabilitation literature. The main objective was to guide physicians, physiotherapists, speech therapists, occupational therapists, nurses, nutritionists, and other professionals involved in post-stroke care. Recommendations and levels of evidence were adapted according to the currently available literature. Part I discusses topics on rehabilitation in the acute phase, as well as prevention and management of frequent conditions and comorbidities after stroke.

RESUMO O objetivo do estudo foi verificar o efeito do tempo de recuperação do exercício nas respostas afetivas durante um treinamento em circuito nas aulas de educação física. Quarenta e seis jovens adolescentes aparentemente saudáveis (vinte e uma meninas), com (12.85 ± 0.94 anos; 49.7 ± 8.93 kg; 1.59 ± 0.08 cm; 19.51 ± 3.28 kg/m2), participaram do estudo. Os participantes foram submetidos a duas aulas de educação física escolar, baseados em modelo de circuitos de mesma intensidade, porém com tempos de recuperação diferentes (2 min e 1 min). O estudo foi realizado em duas fases: base e intervenção. Os dados de Afeto, Ativação e Percepção Subjetiva do Esforço, foram analisados através de testes t pareados, considerando um nível de significância de p < 0,05. A aula com maior tempo de descanso (2 min) proporcionou maior afeto (t(45) = 3.586; p < 0,001) e menor esforço percebido (t(45) = 2.295; p = 0,026). A estratégia de manipulação da intensidade foi efetiva para proporcionar respostas afetivas diferentes, em que a aula percebida como mais intensa resultou no declínio do afeto.

ABSTRACT This study aimed to verify the effect of exercise recovery time on the affective responses during a circuit training in physical education classes. Forty-six apparently healthy young adolescents (twenty-one girls) (12.85 ± 0.94 years; 49.7 ± 8.93 kg; 1.59 ± 0.08 cm; 19.51 ± 3.28 kg/m2) participated in this study. Were submitted participants for two physical education classes, based on circuited model of the same intensity, but with different recovery times (2 min and 1 min). The study was carried out in two phases: baseline and intervention. Affect, Arousal, and Ratings of Perceived Exertion data were analyzed using paired t-tests, considering a significance level of p < 0.05. The class with longer rest time (2 min) provided greater affection (t(45) = 3.586; p < 0,001) and less perceived effort (t(45) = 2.295; p = 0,026). The intensity manipulation strategy was effective in providing different affective responses, in which classes perceived as more intense, resulting in the decline of affect.