ABSTRACT. Management systems that include trees tend to provide higher amounts of plant biomass to the soil, contributing to the increase in carbon (C) and nitrogen (N) stocks. This study simulated C and N stocks and their compartments in a crop-livestock-forest integration system in the edafoclimatic conditions of the Maranhão Cerrado using the Century 4.5 model. The evaluated areas were native Cerrado vegetation (NV) and crop-livestock-forest integration (CLFI). The calibration process gradually modified the model parameters to better fit the simulated and observed soil C and N stocks. The best fit between the data was obtained after changes in the main parameters (DEC3(2), DEC4, and DEC5) that controlled the rate of decomposition of soil organic matter. C and N stocks increased by 14% and 15%, respectively, over 14 years after replacing NV with CLFI. The slow compartment of C presented greater sensitivity to changes in management, with an increase of 47% compared with that of NV. The active compartment increased by 31% and the passive compartment remained constant for over 14 years. Future scenarios, where pasture was maintained between the eucalyptus trees and the scenario that allowed the soybean, corn, and Brachiaria rotation between the trees, were more effective, accumulating approximately 37 Mg C ha-1. The continuous contribution of residues from the trees and pasture increased C and N stocks in the long-term in the slow fraction, where the total organic carbon increased from 32 to 36 Mg ha-1 when NV was replaced with CLFI. The model predicted the C and N stocks with accuracies ranging from 1 to 11% of the observed values. ABSTRACT (C (N croplivestockforest crop livestock forest 45 4 5 4. (NV CLFI . (CLFI) DEC32, DEC32 DEC DEC3 2 , (DEC3(2) DEC4 DEC5 matter 15 15% respectively management 47 31 scenarios soybean corn effective 3 ha1. ha1 ha 1. longterm long term fraction ha- 11 values (CLFI (DEC3(2 (DEC3( (DEC3 (DEC

ABSTRACT Diversifying pastures with forage legumes may reduce nitrogen fertilization due to biological N fixation. This study aimed to quantify forage accumulation rate and macronutrients extraction and to identify the best intercropping combination between butterfly pea (Clitoria ternatea) – a legume, and three warm-season forage grasses of different growth habits (signalgrass – Urochloa decumbunes, Guinea grass - Mega thyrsus maximus, and bermudagrass Cynodon dactylon). Treatments consisted of mixes of perennial herbaceous legume, butterfly pea (twining stem), with grasses, signalgrass (decumbent stem) and Guinea grass (erect stem), and bermudagrass (stoloniferous/rhizomatous). The experiment was arranged in a randomized complete block design, with three treatments and three replications. There was interaction between the intercropping combinations and cutting cycles for forage accumulation rate (FAR) and N, P, K, Ca, Mg, and S uptake. Phosphorus and K uptake was reduced from the second cycle onwards, except for the signalgrass-butterfly pea intercropping, whose reduction was only from the third cycle. Conversely, the signalgrass-butterfly pea and bermudagrass-butterfly pea intercropping did not differ from each other in relation to total N concentration in soil, but the signalgrass-butterfly pea intercropping showed total N concentration in soil higher than that of Guinea grass-butterfly pea intercropping. A higher predominance of the N-NH4+ form was observed in the soil. Grass-legume intercropping increased the demand for nutrients, which makes it indispensable to verify the export of macronutrients to know when to supply these nutrients removed from the soil solution. fixation Clitoria ternatea legume warmseason warm season decumbunes maximus dactylon. dactylon . dactylon) twining stem, stem , decumbent erect stoloniferous/rhizomatous. stoloniferousrhizomatous stoloniferous/rhizomatous stoloniferous rhizomatous (stoloniferous/rhizomatous) design replications FAR (FAR P Ca Mg onwards signalgrassbutterfly Conversely bermudagrassbutterfly grassbutterfly NNH4+ NNH4 NNH NH4+ NH4 NH N-NH4 Grasslegume Grass solution (stoloniferous/rhizomatous N-NH

ABSTRACT. This study aimed to evaluate the nutrition of commercial soybean crops in an agricultural frontier region using the diagnosis and recommendation integrated system (DRIS) and compositional nutrient diagnosis (CND) methods, as well as identify sufficiency ranges. The study was performed by collecting leaf samples (third trifoliate leaf without petiole) at flowering from commercial soybean crops in the states of Piauí and Maranhão, Brazil, and evaluating the crop yield by analyzing macro- and micronutrients in the plant tissue of 98 samples. The DRIS and CND methods were applied based on the cataloged data, followed by the generation of norms, analysis of relationships between yield and nutrients (selecting high-yield crops by the cumulative function of the data), generation of sufficiency ranges, and comparison of methods. The relationships obtained by the DRIS and CND indices with the yield and nutrients were significant, indicating that both methods can be employed for the evaluation of leaf nutrients in soybean. The sufficiency ranges from the DRIS and CND methods presented superior nutrient ranges in relation to the values proposed in the literature for macronutrients, except for nitrogen, and greater range amplitudes for micronutrients. ABSTRACT (DRIS (CND third petiole Maranhão Brazil macro 9 data norms selecting highyield high , data) significant macronutrients nitrogen

ABSTRACT: Verminosis in small ruminants can render rural activity impractical, which is still controlled through the administration of anthelmintics. The present study evaluated four agro-industrial residues as fertilizer in the control of GIN of small ruminants in the free-living stage. Crab shell, manipueira, biochar, and organomineral residues were used in pots (5.0 kg of soil) and cultivated with Massai grass (Megathyrsus maximum cv. Massai). Further, the pots were contaminated with feces from sheep carrying a natural multispecific infection by GIN. Next, the residues were applied individually to the soil, with 50 mL/pot for liquid and 50 g/pot for solid residues. Treatment with manipueira showed the lowest number of L3.kg MS-1 recovered from the grass (202.44), when compared with treatments using organomineral (823.89) and biochar (689.34). However, there was no statistically significant difference (P < 0.05) between the four treatments as compared to the control group. These agro-industrial residues can be used as organic fertilizers; however, these will not help in the control of GIN in sheep. ABSTRACT impractical anthelmintics agroindustrial agro industrial freeliving free living stage shell 5.0 5 0 (5. soil Megathyrsus cv Massai. . Massai) Further Next mLpot mL pot gpot g L3kg Lkg L3 L MS1 MS 1 MS- 202.44, 20244 202.44 , 202 44 (202.44) 823.89 82389 823 89 (823.89 689.34. 68934 689.34 689 34 (689.34) However P 0.05 005 05 group fertilizers however 5. (5 2024 202.4 20 4 (202.44 823.8 8238 82 8 (823.8 6893 689.3 68 3 (689.34 0.0 00 ( 202. 2 (202.4 823. (823. 689. 6 (689.3 0. (202. (823 (689. (202 (82 (689 (20 (8 (68 (2 (6

RESUMO: A verminose em pequenos ruminantes é uma doença que pode inviabilizar a atividade rural. Embora o sucesso no controle dos nematóides gastrointestinais de pequenos ruminantes dependa da adoção associada de diferentes estratégias e tecnologias, ainda é possível notar a escolha, por parte de alguns ovinocaprinocultores, pelo tratamento exclusivamente baseado na administração de anti-helmínticos aos animais. Contudo, é no ambiente que encontramos um elevado número de formas imaturas de nematóides gastrointestinais. Objetivou-se com o presente trabalho avaliar quatro resíduos agroindustriais como adubo no controle dos nematóides gastrointestinais de pequenos ruminantes, em estádio de vida livre. Casca de caranguejo, manipueira, biochar e organomineral foram os resíduos empregados nos vasos com capacidade média de 5,0 kg de solo, onde foi cultivado o capim Massai (Megathyrsus maximus cv. Massai). Após corte de uniformização do capim, os vasos foram contaminados utilizando-se fezes de ovinos portadores de infecção natural multiespecífica por nematóides gastrointestinais. E, na sequência, os resíduos foram aplicados individualmente no solo, na quantidade de 50 mL/vaso para o resíduo líquido e 50 g/vaso para os sólidos. O tratamento com a manipueira foi o que apresentou o menor número de larvas infectantes de terceiro estádio (L3) recuperado do capim (202,44 L3.kg MS-1) quando comparado com os tratamentos utilizando organomineral (823,89 L3.kg MS-1) e biochar (689,34 L3.kg MS-1). Contudo, não houve diferença estatística significativa (P < 0,05) entre os quatro tratamentos testados quando comparado ao grupo controle. Os resíduos agroindustriais podem ser utilizados como adubos orgânicos, mas não vão auxiliar no controle dos nematóides gastrintestinais dos ovinos. RESUMO rural tecnologias escolha ovinocaprinocultores antihelmínticos anti helmínticos animais Contudo Objetivouse Objetivou se livre caranguejo 5 0 5, solo Megathyrsus cv Massai. . Massai) utilizandose E sequência mLvaso mL vaso gvaso g sólidos L3 L (L3 202,44 20244 202 44 (202,4 L3kg Lkg MS1 MS 1 MS-1 823,89 82389 823 89 (823,8 689,34 68934 689 34 (689,3 MS1. P 0,05 005 05 orgânicos (L 202,4 2024 20 4 (202, MS- 823,8 8238 82 8 (823, 689,3 6893 68 3 (689, 0,0 00 202, 2 (202 823, (823 689, 6 (689 0, (20 (82 (68 (2 (8 (6 (

ABSTRACT Agroforestry systems have the potential to increase soil organic matter, with effects on soil carbon and nitrogen contents, but information on the application of these systems in semi-arid regions is still scarce. This study aimed to analyze soil carbon and nitrogen stocks in the conversion of native forest from the Caatinga Biome into integrated agriculture systems in the Brazilian semi-arid region. We evaluated the following management systems in the Haplic Inceptisol (Cambissolo Háplico eutrófico): (1) Intercropping area, cultivated with corn and Massai grass; (2) Caatinga (natural vegetation); (3) AFS10: agroforestry system with native woody forest rows occupying 33 % and agriculture occupying 66 % of the total area; and (4) AFS20: agroforestry system presenting inverse proportions of AFS10. The agroforestry systems were intercropped with sorghum or millet, pigeon pea and Massai grass. We collected disturbed and undisturbed soil samples at the layers of 0.00-0.10; 0.10-0.20; 0.20-0.40, 0.40-0.60 and 0.60-1.00 m for analysis of carbon (SOC), nitrogen (N), soil bulk density, and calculation of SOC and N stocks and C/N ratio, two years after the conversion of natural vegetation to the agricultural area (intercropping) and agroforestry system (AFS10 and AFS20). We applied principal component and cluster analysis to explore the data, and confidence interval to compare the means of accumulated SOC and N stocks up to 1 m soil depth. No differences exist for the properties analysed in superficial layers (0.00-0.10 and 0.10-0.20 m), regardless of land-use systems. AFS20 increase the SOC content and, consequently, SOC stock, in subsurface layers; on the other hand, intercropping increases N content and N stock. AFS20 presented higher accumulated SOC stocks up to 1.00 m (114.97 Mg ha-1). Agroforestry systems management is an alternative for increasing carbon sequestration under the conversion from Caatinga to agricultural areas. matter contents semiarid semi arid scarce region Cambissolo eutrófico eutrófico) (1 grass 2 (2 vegetation) 3 (3 AFS10 AFS 6 4 (4 millet 0.000.10 000010 0.00 0.10 0 00 10 0.00-0.10 0.100.20 010020 0.20 20 0.200.40, 020040 0.40, 40 0.20-0.40 0.400.60 040060 0.40 0.60 60 0.40-0.6 0.601.00 060100 0.60-1.0 SOC, , (SOC) N, (N) density CN C ratio (intercropping (AFS1 AFS20. . AFS20) data depth (0.00-0.1 0.10-0.2 m, m) landuse land use AFS2 consequently stock hand 100 1.0 114.97 11497 114 97 (114.9 ha1. ha1 ha ha-1) areas ( AFS1 000 0.000.1 00001 0.0 010 0.1 0.00-0.1 0.100.2 01002 020 0.2 200 0.200.40 02004 040 0.20-0.4 400 0.400.6 04006 0.4 060 0.6 0.40-0. 601 0.601.0 06010 0.60-1. (SOC (N (AFS (0.00-0. 0.10-0. 1. 114.9 1149 11 9 (114. ha-1 0.000. 0000 0. 01 0.00-0. 0.100. 0100 02 0.200.4 0200 04 0.20-0. 0.400. 0400 06 0.40-0 0.601. 0601 0.60-1 (0.00-0 0.10-0 114. (114 ha- 0.000 0.00-0 0.100 0.200. 0.20-0 0.400 0.40- 0.601 0.60- (0.00- 0.10- (11 0.00- 0.200 0.20- (0.00 (0.0 (0. (0

ABSTRACT. This study was performed to investigate the effects of composted tannery sludge (CTS) on the physical properties of tropical sandy soil after seven years of CTS application. CTS was applied to a Fluvisol at five rates (0.0, 2.5, 5.0, 10.0, and 20.0 Mg ha-1) in experimental plots (sized 20 m2) with four replications. Water infiltration into the soil was determined in the field with the concentric-ring infiltrometer method. Bulk density, total porosity, macroporosity, and microporosity were determined in the soil samples. The permanent CTS application altered the physical properties of the soil and led to a decrease in bulk density. The total porosity, microporosity and macroporosity values in the CTS-applied soil ranged from 44.1-51.7, 34.6-39.4, and 9.1-12.8%, respectively. Water-infiltration rates were significantly influenced by CTS. The cumulative infiltrated water in the soil varied from 21.3-34.7 cm. The basic infiltration rate was lower in the unamended soil and increased with an increase in the rate of CTS application. This study confirmed that the physical soil parameters improved after the permanent CTS application. Therefore, this application may be a suitable strategy for improving physical soil properties over time. ABSTRACT (CTS 0.0, 00 0 (0.0 25 2 5 2.5 50 5.0 100 10 10.0 200 20. ha1 ha 1 ha-1 sized m2 m replications concentricring concentric ring method density porosity samples CTSapplied 44.151.7, 441517 44.1 51.7, 44 51 7 44.1-51.7 34.639.4, 346394 34.6 39.4, 34 6 39 4 34.6-39.4 9.112.8%, 91128 9.1 12.8%, 9 12 8 9.1-12.8% respectively Waterinfiltration 21.334.7 213347 21.3 34.7 21 3 21.3-34. cm Therefore time 0.0 (0. 2. 5. 10. ha- 151 44.151.7 44151 441 44. 517 51.7 44.1-51. 639 34.639.4 34639 346 34. 394 39.4 34.6-39. 112 9.112.8% 9112 91 9. 128 12.8% 9.1-12.8 334 21.334. 21334 213 21. 347 21.3-34 0. (0 15 44.151. 4415 51. 44.1-51 63 34.639. 3463 39. 34.6-39 11 9.112.8 911 12.8 9.1-12. 33 21.334 2133 21.3-3 ( 44.151 44.1-5 34.639 34.6-3 9.112. 12. 9.1-12 21.33 21.3- 44.15 44.1- 34.63 34.6- 9.112 9.1-1 9.11 9.1-

ABSTRACT The aim was to evaluate the productive performance and nutrient export of maize intercropped with drought-tolerant forage grasses. The experimental design was a randomized blocks in a 2x2x2+1 factorial scheme (two forage grasses species – Massai and Buffel; two forage sowing methods - in the furrow and broadcast; and two forage sowing times - anticipated and simultaneous; and monoculture maize as an additional control), with three replicates. The maize+forage intercropping promoted greater competition for resources, especially water, limiting N uptake, chlorophyll synthesis, and biomass production by maize under semiarid conditions. Early sowing gave forage plants a competitive advantage, favoring forage establishment before or immediately after the sowing of maize. Thus, the simultaneous sowing of forage grasses in a semiarid environment is a more appropriate option considering the importance of high levels of chlorophyll to ensure high photosynthetic activity in maize plants and greater capacity of biomass synthesis. Massai intercropped with maize exhibits a greaterpotential for biomass production than Buffel under semiarid conditions. Maize+Buffel result in highest macronutrient export by maize, while maize+Massai result in highest macronutrient exports by total forage biomass under a semiarid environment. The choice of the forage species and its sowing time in relation to maize are the main determinants of successful intercropping systems under semiarid conditions. droughttolerant drought tolerant 2x2x21 xx 2x2x2 1 x 2x2x2+ broadcast control, control , control) replicates maizeforage resources water uptake synthesis conditions advantage Thus MaizeBuffel Maize maizeMassai 2x2x

RESUMO O objetivo foi avaliar o desempenho produtivo e a exportação de nutrientes do consórcio de milho com gramíneas forrageiras tolerantes ao estresse hídrico. O experimento foi delineado em blocos casualizados em esquema fatorial 2x2x2+1 (duas espécies de gramíneas forrageiras – Massai e Buffel; dois métodos de semeadura – no sulco e a lanço; e duas épocas de semeadura – antecipada e simultânea; e monocultivo de milho como um controle adicional), com três repetições. O consórcio milho+forragem promoveu maior competição por recursos, principalmente água, limitando a absorção de N, síntese de clorofila e produção de biomassa pelo milho para condições semiáridas. A semeadura precoce deu vantagem competitiva às plantas forrageiras, favorecendo seu estabelecimento antes ou imediatamente após a semeadura do milho. Assim, a semeadura simultânea de gramíneas forrageiras em ambiente semiárido é uma opção mais adequada, considerando a importância de garantir altos teores de clorofila e, consequentemente, alta atividade fotossintética nas plantas de milho para garantir a capacidade de síntese de biomassa.Massai consorciado com milho apresenta maior potencial para produção de biomassa do que Buffel em condições semiáridas.Milho+Buffel resulta em maior exportação de macronutrientes pelo milho, enquanto milho+Massai resulta em maior exportação de macronutrientes pela biomassa forrageira total em ambiente semiárido.A escolha da espécie forrageira e sua época de semeadura em relação ao milho são os principais determinantes do sucesso do consórcio no semiárido. hídrico 2x2x21 xx 2x2x2 1 x 2x2x2+ lanço adicional, adicional , adicional) repetições milhoforragem forragem recursos água N semiáridas Assim adequada consequentemente biomassaMassai semiáridasMilhoBuffel Milho milhoMassai semiáridoA 2x2x

Abstract Phosphorus (P) is one of the main nutrients capable of increasing yields of tropical grasses. The definition of adequate P fertilizer rates can contribute to improving forage production of pastures. However, the efficiency in the response of different genotypes of Urochloa mosambicensis (Hack.) Dandy (Bushveld herringbone grass) to P fertilizer rates is not known. This study aimed to quantify the response of U. mosambicensis genotypes to P fertilizer levels and classify the genotypes as to efficiency and responsiveness. The experiment was carried out in pots, under controlled conditions, in a completely randomized design, in a 2 x 9 factorial with five replications. The factors consisted of equivalent P rates of 10 and 90 kg ha-1 of P2O5 (triple superphosphate) and eight genotypes of U. mosambicensis (UmCO-1 (2), UmCO-2 (2), UmCO-4 (1), UmCO-8 (1), UmCO-11 (2), UmCO-12 (2), UmCO-13 (2) and UmCO-14 (2)), in addition to a control, Urochloa brizantha syn. Brachiaria brizantha cv. BRS Piatã. Each experimental unit consisted of one pot. Biometric attributes and dry mass yield were evaluated over four cutting cycles. There was no effect of the P fertilization x genotypes interaction for the variables evaluated. However, the highest fertilizer rate increased dry mass yield and tiller population density in all genotypes and cuttings evaluated. The genotype UmCO-4 (1) and the cultivar BRS Piatã proved to be responsive to and efficient in P use. The highest P rate promoted greatest production of dry mass and greatest number of tillers in all genotypes of U. mosambicensis. (P grasses pastures However Hack. Hack (Hack. Bushveld grass known U responsiveness pots conditions design replications 1 ha1 ha ha- PO O P2O triple superphosphate UmCO1 UmCO (UmCO- 2, , UmCO2 UmCO- UmCO4 4 1, UmCO8 8 UmCO11 11 UmCO-1 UmCO12 12 UmCO13 13 (2 UmCO14 14 (2)) control syn cv pot cycles (1 use (Hack (UmCO (

Resumo O fósforo (P) é um dos principais nutrientes capazes de aumentar a produtividade de gramíneas tropicais. A definição de doses de P pode contribuir para aumentar a produção de forragem em pastagens cultivadas. Todavia não se conhece a eficiência na resposta de diferentes genótipos de capim-corrente (Urochloa mosambicensis (Hack.) Dandy) a doses de P. Este estudo objetivou quantificar a resposta de genótipos de capim-corrente a níveis de adubação com P e classificá-los segundo a sua eficiência e responsividade. O experimento foi conduzido em vasos, em condições controladas, no delineamento inteiramente casualizado, num esquema fatorial 2 x 9, com cinco repetições. Os fatores consistiram de doses equivalentes de P de 10 e 90 kg ha-1 de P2O5 (superfosfato triplo) e oito genótipos de U. mosambicensis (UmCO1 (2), UmCO-2 (2), UmCO-4 (1), UmCO-8 (1), UmCO-11 (2), UmCO-12 (2), UmCO-13 (2) e UmCO-14 (2)), além da testemunha Urochloa brizantha syn. Brachiaria brizantha cv. BRS Piatã. Cada unidade experimental foi constituída de um vaso. Foram avaliados atributos biométricos e rendimento de massa seca ao longo de quatro ciclos de corte. Não houve efeito da interação entre adubação x genótipos para as variáveis avaliadas. Entretanto, a maior dose do fertilizante incrementou o rendimento de massa seca e densidade populacional de perfilhos em todos os genótipos e cortes avaliados. O genótipo UmCO-4 (1) e a cultivar BRS Piatã revelaram-se responsivos e eficientes no uso de P. A maior dose de P promoveu maior produção de massa seca e maior número de perfilhos em todos os genótipos de U. mosambicensis. (P tropicais cultivadas capimcorrente capim corrente Hack. Hack (Hack. Dandy classificálos classificá los responsividade vasos controladas casualizado 9 repetições 1 ha1 ha ha- PO P2O superfosfato triplo U UmCO1 UmCO (UmCO 2, , UmCO2 UmCO- UmCO4 4 1, UmCO8 8 UmCO11 11 UmCO-1 UmCO12 12 UmCO13 13 (2 UmCO14 14 (2)) syn cv vaso corte avaliadas Entretanto (1 revelaramse revelaram (Hack (

ABSTRACT. Dementias secondary to cardiovascular diseases are the second cause of neurogenerative diseases. These conditions can be prevented by controlling risk factors, and it is necessary to observe the relationship between chronic diseases. Objective: to know the influence of chronic non-communicable diseases on cognition and depressive symptoms in the elderly, amid the COVID-19 pandemic. Methods: 578 older adults were evaluated using a sociodemographic questionnaire, the Brazilian Telephone version of the Mini Mental State Examination (Braztel-MMSE), the Geriatric Depression Scale (GDS-15) and an open questionnaire related to NCDs. Results: the association of Non-Communicable Diseases (NCD) with age, depressive symptoms and schooling was confirmed. Conclusion: no association with cognitive decline was evident due to the relationship of high schooling of participants and control of NCDs. ABSTRACT factors Objective noncommunicable non communicable elderly COVID19 COVID 19 COVID-1 pandemic Methods 57 BraztelMMSE, BraztelMMSE Braztel MMSE , (Braztel-MMSE) GDS15 GDS 15 (GDS-15 NCDs Results NonCommunicable Non Communicable NCD (NCD age confirmed Conclusion COVID1 1 COVID- 5 (Braztel-MMSE GDS1 (GDS-1 (GDS- (GDS

RESUMO. As demências secundárias às doenças cardiovasculares são a segunda causa de doenças neurodegenerativas. Essas condições podem ser prevenidas pelo controle de fatores de risco, sendo necessário observar a relação entre doenças crônicas. Objetivo: Conhecer a influência das doenças crônicas não transmissíveis (DCNT) na cognição e nos sintomas depressivos em pessoas idosas, em meio à pandemia da COVID-19. Métodos: Foram avaliados 578 idosos utilizando um questionário sociodemográfico, o Brazilian telephone version of the Mini Mental State Examination (Braztel-MMSE), a Escala de Depressão Geriátrica (GDS-15) e um questionário aberto relacionado às DCNT. Resultados: Foi confirmada a associação das DCNT crônicas com idade, sintomas depressivos e escolaridade. Conclusão: Nenhuma associação com declínio cognitivo foi evidente em razão da relação da alta escolaridade dos participantes com o controle das DCNT. RESUMO neurodegenerativas risco Objetivo (DCNT idosas COVID19. COVID19 COVID 19. 19 COVID-19 Métodos 57 sociodemográfico BraztelMMSE, BraztelMMSE Braztel MMSE , (Braztel-MMSE) GDS15 GDS 15 (GDS-15 Resultados idade Conclusão COVID1 1 COVID-1 5 (Braztel-MMSE GDS1 (GDS-1 COVID- (GDS- (GDS

Abstract Background Migraine affects 1 billion people worldwide and > 30 million Brazilians; besides, it is an underdiagnosed and undertreated disorder. Objective The need to disseminate knowledge about the prophylactic treatment of migraine is known, so the Brazilian Headache Society (SBCe, in the Portuguese acronym) appointed a committee of authors with the objective of establishing a consensus with recommendations on the prophylactic treatment of episodic migraine based on articles from the world literature as well as from personal experience. Methods Meetings were held entirely online, with the participation of 12 groups that reviewed and wrote about the pharmacological categories of drugs and, at the end, met to read and finish the document. The drug classes studied in part II of this Consensus were: antihypertensives, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, calcium channel blockers, other drugs, and rational polytherapy. Results From this list of drugs, only candesartan has been established as effective in controlling episodic migraine. Flunarizine, venlafaxine, duloxetine, and pizotifen were defined as likely to be effective, while lisinopril, enalapril, escitalopram, fluvoxamine, quetiapine, atorvastatin, simvastatin, cyproheptadine, and melatonin were possibly effective in prophylaxis of the disease. Conclusions Despite an effort by the scientific community to find really effective drugs in the treatment of migraine, given the large number of drugs tested for this purpose, we still have few therapeutic options. 3 Brazilians besides disorder known SBCe, SBCe (SBCe acronym experience online end document antihypertensives inhibitors blockers polytherapy Flunarizine venlafaxine duloxetine lisinopril enalapril escitalopram fluvoxamine quetiapine atorvastatin simvastatin cyproheptadine disease purpose options

Resumo Antecedentes Migrânea afeta um bilhão de pessoas em todo o mundo e mais de 30 milhões de brasileiros; além disso, é um distúrbio subdiagnosticado e subtratado. Objetivo Sabe-se sobre a necessidade de difundir o conhecimento sobre o tratamento profilático da migrânea; por isso, a Sociedade Brasileira de Cefaleias (SBCe) nomeou um comitê de autores com o objetivo de estabelecer um consenso com recomendações sobre o tratamento profilático da migrânea episódica com base em artigos da literatura mundial, assim como da experiência pessoal. Métodos As reuniões foram realizadas inteiramente online, com a participação de 12 grupos que revisaram e escreveram sobre as categorias farmacológicas dos medicamentos e, ao final, reuniram-se para a leitura e conclusão do documento. As classes de medicamentos estudadas na parte II deste Consenso foram: anti-hipertensivos, inibidores seletivos de recaptação de serotonina, inibidores de recaptação de serotonina e noradrenalina, bloqueadores dos canais de cálcio, outros medicamentos e politerapia racional. Resultados Desta lista de medicamentos, apenas o candesartan foi estabelecido como eficaz no controle da migrânea episódica. Flunarizina, venlafaxina, duloxetina e pizotifeno foram definidos como provavelmente eficazes, enquanto lisinopril, enalapril, escitalopram, fluvoxamina, quetiapina, atorvastatina, sinvastatina, ciproheptadina e melatonina foram possivelmente eficazes na profilaxia da doença. Conclusões Apesar do esforço da comunidade científica em encontrarmedicamentos realmente eficazes no tratamento da migrânea, dado o grande número de medicamentos testados para este fim, ainda dispomos de poucas opções terapêuticas. 3 brasileiros disso subtratado Sabese Sabe se isso SBCe (SBCe mundial pessoal online 1 final reuniramse reuniram documento antihipertensivos, antihipertensivos anti hipertensivos, hipertensivos anti-hipertensivos noradrenalina cálcio racional Flunarizina venlafaxina lisinopril enalapril escitalopram fluvoxamina quetiapina atorvastatina sinvastatina doença fim terapêuticas

Abstract The Brazilian Headache Society (Sociedade Brasileira de Cefaleia, SBCe, in Portuguese) nominated a Committee of Authors with the aim of establishing a consensus with recommendations regarding prophylactic treatment for episodic migraine based on articles published in the worldwide literature, as well as personal experience. Migraine affects 1 billion people around the world and more than 30 million Brazilians. In addition, it is an underdiagnosed and undertreated disorder. It is well known within the medical community of neurologists, and especially among headache specialists, that there is a need to disseminate knowledge about prophylactic treatment for migraine. For this purpose, together with the need for drug updates and to expand knowledge of the disease itself (frequency, intensity, duration, impact and perhaps the progression of migraine), this Consensus was developed, following a full online methodology, by 12 groups who reviewed and wrote about the pharmacological categories of the drugs used and, at the end of the process, met to read and establish conclusions for this document. The drug classes studied were: anticonvulsants, tricyclic antidepressants, monoclonal anti-calcitonin gene-related peptide (anti-CGRP) antibodies, beta-blockers, antihypertensives, calcium channel inhibitors, other antidepressants (selective serotonin reuptake inhibitors, SSRIs, and dual-action antidepressants), other drugs, and polytherapy. Hormonal treatment and anti-inflammatories and triptans in minimum prophylaxis schemes (miniprophylaxis) will be covered in a specific chapter. The drug classes studied for part I of the Consensus were: anticonvulsants, tricyclic antidepressants, monoclonal anti-CGRP antibodies, and beta-blockers. Sociedade Cefaleia SBCe Portuguese literature experience 3 Brazilians addition disorder neurologists specialists purpose frequency, frequency (frequency intensity duration migraine, , migraine) developed methodology process document were anticonvulsants anticalcitonin anti calcitonin generelated gene related antiCGRP CGRP (anti-CGRP antibodies betablockers, betablockers beta blockers, blockers beta-blockers antihypertensives inhibitors selective SSRIs dualaction dual action antidepressants) polytherapy antiinflammatories inflammatories miniprophylaxis (miniprophylaxis chapter betablockers. blockers.

Resumo A Sociedade Brasileira de Cefaleia (SBCe) nomeou um Comitê de Autores com o objetivo de estabelecer um consenso com recomendações sobre o tratamento profilático da enxaqueca episódica com base em artigos da literatura mundial e da experiência pessoal. A enxaqueca é um distúrbio subdiagnosticado e subtratado que acomete um bilhão de pessoas no mundo e mais de 30 milhões de brasileiros. É conhecido na comunidade médica de neurologistas e, sobretudo, dos especialistas em cefaleia, a necessidade de se divulgar o conhecimento sobre o tratamento profilático da enxaqueca. Com esta finalidade, aliada às necessidades de atualizações de drogas e de se aumentar o conhecimento sobre a doença em si (frequência, intensidade, duração, impacto e talvez a progressão da enxaqueca), foi elaborado este Consenso, com metodologia totalmente on-line, por 12 grupos que revisaram e escreveram sobre as categorias farmacológicas das drogas e, ao final, reuniram-se para a leitura e conclusão do documento. As classes de drogas estudadas para este Consenso foram: anticonvulsivantes, antidepressivos tricíclicos, anticorpos monoclonais do antipeptídeo relacionado ao gene da calcitonina (peptídeo relacionado ao gene da calcitonina — anti-CGRP), betabloqueadores, anti-hipertensivos, inibidores dos canais de cálcio, outros antidepressivos (inibidores seletivos de recaptação de serotonina, ISRSs, e antidepressivos de ação dual), outras drogas, e politerapia. O tratamento hormonal, bem como anti-inflamatórios e triptanas em esquema de profilaxia mínima (miniprofilaxia), será abordado em um capítulo próprio. As classes de drogas estudadas na parte I do Consenso foram: anticonvulsivantes, antidepressivos tricíclicos, anticorpos monoclonais anti-CGRP, e betabloqueadores. SBCe (SBCe pessoal 3 brasileiros sobretudo cefaleia finalidade frequência, frequência (frequência intensidade duração enxaqueca, , enxaqueca) online, online on line, line on-line 1 final reuniramse reuniram documento foram anticonvulsivantes tricíclicos peptídeo antiCGRP, antiCGRP anti CGRP anti-CGRP) betabloqueadores antihipertensivos, antihipertensivos hipertensivos, hipertensivos anti-hipertensivos cálcio serotonina ISRSs dual, dual dual) politerapia hormonal antiinflamatórios inflamatórios miniprofilaxia, miniprofilaxia (miniprofilaxia) próprio CGRP, anti-CGRP (miniprofilaxia

RESUMO Os solos leves possuem maior suscetibilidade ao processo de degradação e necessitam ser explorados de forma conservacionista, evitando assim sua rápida degradação. Objetivou-se com o estudo avaliar as propriedades físico-hídricas de um Argissolo sob plantio direto e integração lavoura-pecuária no Cerrado da região leste do estado do Maranhão. Os manejos avaliados foram uma área sob sistema de plantio direto há quatorze anos (soja/milheto) e três áreas com diferentes históricos de adoção do sistema de integração lavoura-pecuária (ILP) sob plantio direto (soja/milheto), sendo a diferença os tempos de entrada com ILP (2, 4 e 8 anos), além de uma área de cerrado nativo, considerado testemunha. A coleta do solo foi realizada em junho de 2018 nas profundidades de 0,00-0,10; 0,10-0,20; 0,20-0,30; 0,30-0,50 m. Foram coletadas amostras deformadas e indeformadas, para determinação das variáveis: densidade do solo, porosidade, resistência à penetração, curva de retenção e capacidade de água disponível. Os dados foram submetidos ao cálculo das médias e de intervalo de confiança (95 %). A área com histórico recente de integração lavoura-pecuária apresentou melhor densidade, porosidade, resistência a penetração e capacidade de armazenamento e água disponível. O plantio direto há quatorze anos apresenta alta resistência a penetração, menor porosidade e baixa capacidade de armazenamento de água. O sistema integrado (ILP) melhora a qualidade das propriedades físico - hídricas, sendo o sistema com maior capacidade de água disponível para as plantas.

ABSTRACT Light soils are more susceptible to degradation and need to be exploited in a conservational manner, thus avoiding rapid degradation. The objective of this study was to evaluate the physical-hydraulic properties of an Ultisol under no-tillage and crop-livestock integration in the Cerrado of eastern Maranhão state, Brazil. The evaluated managements were one area under no-tillage system for fourteen years (soybean/ millet) and three areas with different histories of adoption of the crop-livestock integration (CLI) system under no-tillage (soybean/millet), with the difference being: times of entry with CLI (2, 4 and 8 years), as well as a native Cerrado area, considered a control. Soil collection was carried out in June 2018 at depths of 0.00-0.10, 0.10-0.20, 0.20-0.30 and 0.30-0.50 m. Disturbed and undisturbed samples were collected to determine the following variables: bulk density, porosity, resistance to penetration, retention curve and available water capacity. Data were subjected to the calculation of means and confidence intervals (95%). The area with a recent history of crop-livestock integration showed better density, porosity, resistance to penetration, water storage capacity and available water. No-tillage for fourteen years leads to high resistance to penetration, less porosity and low water storage capacity. The integrated system (CLI) improves the quality of the physical- hydraulic properties and the values found are similar to those observed in an area under native vegetation.

RESUMO: Os sistemas integrados de produção agropecuária possuem potencial de incrementar a matéria orgânica, com reflexos nas concentrações de carbono e de nitrogênio no solo. O objetivo do trabalho foi avaliar estoques de carbono e nitrogênio e seus compartimentos em um Argissolo Amarelo Distrocoeso típico sob plantio direto e integração lavoura-pecuária no Leste maranhense. Os manejos avaliados foram: sistema de plantio direto em sucessão há 14 anos (soja/milheto), três áreas com diferentes históricos de sucessão com a adoção do sistema integração lavoura-pecuária (ILP), sendo dois, quatro e oito anos, além de uma área de Cerrado nativo. Foram coletadas amostras de solo nas profundidades de 0,00-0,10; 0,10-0,20; 0,20-0,30; 0,30-0,50 metros para análise de teores e estoques totais de carbono (C) e de seus compartimentos (físico e químico), nitrogênio (N) e da biomassa microbiana do solo e respiração basal. Os resultados revelam maior teor e estoque de C e N nas áreas com ILP. A substância húmica predominante foi a humina e maiores concentrações do carbono associado a minerais estiveram presentes na área sob ILP mais recente (dois e quatro anos). A adoção da ILP, mesmo que recente, proporciona incrementos imediatos nas concentrações de C e suas frações em função do emprego de forrageiras. O plantio direto há 14anos e ILP há oito anos são sistemas com maior índice de manejo do C, como, também, apresentam maior atividade biológica do solo, devido à maiores estabilidade destes sistemas.

ABSTRACT: Integrated agricultural production systems have the potential to increase organic matter content, which is reflected in the soil carbon (C) and nitrogen (N) concentrations. Here, we evaluated the C and N stocks and its compartments in a typical distro cohesive yellow Ultisol under the no-till (NT) and crop-livestock integration (CLI) systems, in eastern Maranhão. Five areas with different management strategies were evaluated, more specifically, one area was managed under the NT system in succession for 14 years (soybean/millet), three areas had different CLI system adoption histories (i.e., CLI was adopted 2, 4, or 8 years prior to sample collection); and finally, one area consisted of native Cerrado (savannah) vegetation. Soil samples were collected at depths of 0-0.10, 0.10-0.20, 0.20-0.30, and 0.30-0.50 m,to analyze the content and total stocks of carbon (C) and its compartments (physical and chemical), N content, soil microbial biomass, and basal respiration. Results revealed higher content and stock of C and N in areas with CLI. The principal humic substance reported was humin, and higher concentrations of C associated with minerals were present in areas under more recent CLI adoption (2 and 4 years). We demonstrated that the adoption of CLI, even if recent, leads to immediate increases in the concentrations of C and its fractions as a result of using forage crops. NT for 14 years and CLI for 8 years exhibited higher levels of C management and higher soil biological activity due to the greater stability of these systems.

RESUMO Objetivou-se avaliar os parâmetros fisiológicos, as características produtivas, estruturais e composição química de Megathyrsus maximus (syn. Panicum maximum) cultivares BRS Massai e BRS Tamani submetidas à diferentes períodos de diferimento e momentos de utilização. Utilizou-se o delineamento de blocos completos casualizados, em esquema fatorial 2 x 2 x 3, sendo duas cultivares de gramíneas (capim-massai e capim-tamani), dois períodos de diferimento (período chuvoso e transição chuvoso-seco) e três tempos de vedação (40, 80 e 120 dias). Ambas as cultivares tiveram maior taxa de transpiração foliar quando utilizadas aos 40 dias de diferimento (0,63 μmol/m2/s). Observou-se que a cultivar BRS Massai apresentou a maior taxa fotossintética (1,10 μmol/m²/s), taxa de produção e acúmulo de forragem quando utilizada aos 40 dias de diferimento (P<0,05). Por outo lado, houve maior eficiência no uso da água durante o período de transição nos pastos vedados por 80 e 120 dias (64,60 e 62,30 kg de MS/ha/mm, respectivamente). Observou-se redução (P<0,05) dos nutrientes digestíveis totais (NDT) e proteína bruta (PB) com o aumento no tempo de vedação das pastagens. De modo geral o diferimento no período de transição possibilita a utilização da forragem sem maiores perdas produtivas e nutritivas até os 80 dias de vedação para a cultivar BRS Tamani e até os 40 dias para a BRS Massai.

ABSTRACT This study aimed to evaluate the physiological parameters, the productive characteristics, structural and chemical composition of Megathyrsus maximus (syn. Panicum maximum) cultivars BRS Massai and BRS Tamani submitted to different periods of deferment and moments of use. The experimental design was randomized complete block design in a factorial scheme 2 x 2 x 3, being two grass cultivars (Massai grass and Tamani grass), two deferment periods (rainy season and dry-rainy transition) and three sealing times (40, 80 and 120 days). Both cultivars had higher leaf transpiration rate when used for 40 days of deferment (0.63 μmol/m2/s). It was observed that the cultivar BRS Massai presented higher photosynthetic rate (P<0.05) to 40 days of deferment (1.10 μmol/m2/s), higher rate of production and forage accumulation when used for 40 days. On another side, there was a greater efficiency in the use of water during the period of transition in the pastures sealed for 80 and 120 days (64.60 and 62.30 kg DM/ha/mm, respectively). A reduction (P<0.05) of total digestible nutrients (TDN) and crude protein (CP) was observed with the increase in pasture sealing time. In general, the deferment in the transition period allows the use of forage without greater productive and nutrient losses up to 80 days of sealing for the cultivar BRS Tamani and up to 40 days for BRS Massai.

RESUMO Objetivou-se avaliar, por meio de análise multivariada de dados, quais resíduos de leguminosas arbóreas tem melhor potencial fertilizante para culturas agrícolas no semiárido nordestino brasileiro. O experimento foi conduzido em vasos, em delineamento aleatorizado em blocos, com sete tratamentos e quatro repetições. Para constituir os tratamentos utilizaram-se resíduos de sabiá, jurema-preta e gliricídia; além de duas partes da planta: folhas e folhas mais galhos. Os vasos foram preenchidos com 8,0 dm3 de solo e os resíduos foram adicionados na forma de massa verde, correspondendo a 73,0 g de massa seca por vaso. Sementes de milho foram semeadas e aos 65 dias após adição dos resíduos avaliou-se atributos químicos do solo, crescimento e teores de nutrientes das plantas. Os dados foram estudados por meio das análises de componentes principais, agrupamento, função discriminante canônica e teste de comparação de médias a partir da varável canônica 1. Resíduos de gliricídia influenciaram positivamente K e Mg do solo, bem como altura, diâmetro do caule, número de folhas e teores foliares de P, N e Mg em plantas de milho. Estes resíduos apresentaram maior dissimilaridade e separação em relação ao tratamento controle e proporcionaram médias estatisticamente superiores aos demais tratamentos. Folhas de jurema-preta influenciaram positivamente Ca, N e COT do solo, bem como teores foliares de K e Ca e matéria seca total do milho. A análise estatística multivariada permitiu identificar potenciais distintos entre resíduos de leguminosas para uso como fertilizante na cultura do milho, sendo a espécie gliricídia a que apresenta maior potencial.

ABSTRACT The objective of this study was to evaluate, through multivariate data analysis, which tree legume residues have the best fertilizer potential for agricultural crops in the semi-arid region of northeastern Brazil. The experiment was conducted in pots, in a randomized block design, with seven treatments and four replicates. Treatments consisted of residues of Sabiá, Jurema Preta and Gliricidia, besides two parts of the plant: leaves and leaves + branches. The pots were filled with 8.0 dm3 of soil and the residues were added in the form of green mass, corresponding to 73.0 g of dry mass per pot. Maize seeds were sown and, at 65 days after addition of the residues, soil chemical attributes, growth and nutrient contents in the plants were evaluated. The data were studied through principal component analysis, clustering analysis, canonical discriminant function analysis and means comparison test from canonical variable 1. Gliricidia residues positively influenced soil K and Mg contents, as well as height, stem diameter, number of leaves and leaf contents of P, N and Mg in maize plants. These residues showed greater dissimilarity and separation compared to the control treatment and led to statistically higher means compared to the other treatments. Jurema Preta leaves positively influenced soil Ca, N and TOC, as well as leaf contents of K and Ca and total dry mass of maize. Multivariate statistical analysis made it possible to identify distinct potentials among legume residues for use as fertilizer in maize crop, and Gliricidia is the species with highest potential.