ABSTRACT BACKGROUND AND OBJECTIVES: Temporomandibular disorder (TMD) is the term used to describe a set of painful and functional conditions that can affect the temporomandibular joint (TMJ), the masticatory muscles and/or their associated structures. For myofascial TMD, conservative therapies, including drugs, physical therapy, occlusal splint and pain self-management show the best benefits to the patient. The objective of this study was to carry out, through a bibliometric analysis, a review of the existing knowledge regarding the treatments used in myofascial TMD. CONTENTS: The search was conducted in the Web of Science (WOS) and SCOPUS databases in July and updated in December 2023, through the MeSh descriptors “Temporomandibular Joint Dysfunction Syndrome” and “Therapeutics”. Moreover, bibliometric mapping was performed using the VOSviewer software. For the analysis, data on the terms of the title and abstract, type of document, number of citations, name of journals, most cited article and year of publication were included. Besides these, the country of the corresponding author, type of treatment, type of study and the results were included in the analysis. Of the 760 articles identified, 63 were selected to compose this review. Of these, most were original articles, clinical trials and were published in 2012. The most frequent treatments were: occlusal splint, laser, manual therapy, botulinum toxin and dry needling. Of the 15 countries analyzed, Brazil was the country with the highest number of publications. CONCLUSION: There was an increase in articles published on the topic, with Brazil being the country with the highest number of publications. Finally, the most used treatments were occlusal splint and laser. OBJECTIVES TMD (TMD TMJ, TMJ , (TMJ) andor or structures therapies drugs therapy selfmanagement self management patient out analysis CONTENTS WOS (WOS 2023 Syndrome Therapeutics. Therapeutics . “Therapeutics” Moreover software abstract document citations journals these author treatment 76 identified 6 2012 laser needling 1 analyzed publications CONCLUSION topic Finally (TMJ 202 “Therapeutics 7 201 20 2

RESUMO JUSTIFICATIVA E OBJETIVOS: Disfunção temporomandibular (DTM) é um termo utilizado para descrever um conjunto de condições dolorosas e funcionais que podem afetar a articulação temporomandibular (ATM), os músculos mastigatórios e/ou suas estruturas associadas. Para DTM miofascial, terapias conservadoras, incluindo fármacos (analgésicos e/ou anti-inflamatórios), fisioterapia, placa oclusal e autogestão da dor apresentam os melhores benefícios para o paciente. O objetivo deste estudo foi abordar, através de uma análise bibliométrica, o conhecimento existente sobre os tratamentos utilizados na DTM de origem miofascial. CONTEÚDO: A busca foi realizada na base de dados Web of Science (WOS) e SCOPUS, em julho e atualização em dezembro de 2023, por meio dos descritores do MeSh “Temporomandibular Joint Dysfunction Syndrome” e “Therapeutics”. Além disso, um mapeamento bibliométrico foi realizado no software VOSviewer. Para análise, foram incluídos dados sobre os termos do título e do resumo, tipo de documento, número de citações, nome dos periódicos, artigo mais citado e ano de publicação e, além destes, o país do autor correspondente, tipo de tratamento, tipo de estudo e resultados. Dos 760 artigos identificados, 63 foram selecionados para compor esta revisão. Destes, a maioria era artigos originais, ensaios clínicos e foram publicados em 2012. Os tratamentos mais frequentes foram: placa oclusal, laser, terapia manual, toxina botulínica e agulhamento a seco. Dos 15 países analisados, o Brasil foi o país com maior número de publicações. CONCLUSÃO: Houve um aumento de artigos sobre a temática publicados, sendo o Brasil o país com mais publicações e os tratamentos mais utilizados foram placa oclusal e laser. OBJETIVOS (DTM ATM, ATM , (ATM) eou ou associadas miofascial conservadoras analgésicos antiinflamatórios, antiinflamatórios anti inflamatórios anti-inflamatórios) fisioterapia paciente abordar bibliométrica CONTEÚDO WOS (WOS SCOPUS 2023 Temporomandibular Syndrome Therapeutics. Therapeutics . “Therapeutics” disso VOSviewer resumo documento citações periódicos destes correspondente tratamento resultados 76 identificados 6 revisão Destes originais 2012 laser manual seco 1 analisados CONCLUSÃO (ATM anti-inflamatórios 202 “Therapeutics 7 201 20 2

Abstract Objective To compare polysomnographic parameters with others from the literature in order to provide more accurate information about Rapid Maxillary Expansion (RME) for treating Obstructive Sleep Apnea (OSA) in children, through raising the question: Is RME a good option for treating OSA in children? Prevention of mouth breathing during children's growth remains a challenge with significant clinical consequences. In addition, OSA induces anatomofunctional changes during the critical period of craniofacial growth and development. Methods The Medline, PubMed, EMBASE, CINAHL, Web of Science, SciELO and Scopus electronic databases were searched up to February 2021 for systematic reviews with meta-analysis in the English language. Among 40 studies on RME for treating OSA in children, we selected seven in which polysomnographic measurements of the Apnea-Hypopnea Index (AHI) had been made. Data were extracted and examined in order to clarify whether any consistent evidence exists for indicating RME as a treatment for OSA in children. Results We found no consistent evidence favoring RME for long-term treatment of OSA in children. All the studies presented considerable heterogeneity due to variability of age and length of follow-up. Conclusion Through this umbrella review, the need for methodologically better studies on RME is supported. Moreover, it can be considered that RME is not recommended for treating OSA in children. Further studies and more evidence identifying early signs of OSA are necessary in order to achieve consistent healthcare practice. (RME (OSA children question childrens s consequences addition development Medline PubMed EMBASE CINAHL Science 202 metaanalysis meta analysis language 4 ApneaHypopnea Hypopnea AHI (AHI made longterm long term followup. followup follow up. follow-up review supported Moreover practice 20 2

Abstract Objective To review, critically analyze and synthesize knowledge from the international literature regarding the association between allergic rhinitis (AR) and sleep disorders, the impact of AR treatment on children's sleep, and lay the foundation for future research on this topic. Source of data A literature search using PubMed database including original and review articles, systematic reviews and meta-analyses using keywords related to AR, sleep disorders and sleep-disordered breathing. Synthesis of data Sleep is fundamental to health, and its assessment and control of conditions that trigger or aggravate disturbances are of the uttermost importance. Allergic rhinitis (AR) is common in children and may interfere with both their quality of life and quality of sleep. It has emerged as one of the most important risk factors for habitual snoring in children and appeared to increase the risk of Obstructive Sleep Apnea (OSA), with AR severity exhibiting a significant and independent association with pediatric OSA severity. However, in some studies, those associations between AR and OSA in children are not very consistent. Conclusions A substantial level of controversy exists regarding the interactions between AR and OSA in children. Notwithstanding, identifying and treating AR in clinical settings is probably an important step toward improving symptoms and preventing deterioration of sleep quality in children and may improve the severity of underlying OSA. Considering the high prevalence, morbidity, economic and social implications of both AR and sleep problems, it is crucial that healthcare providers improve their understanding of the relationships between those conditions among children.

RESUMO JUSTIFICATIVA E OBJETIVOS: A literatura tem demonstrado que as modalidades comportamentais e educacionais são opções efetivas no tratamento da dor crônica, inclusive da disfunção temporomandibular, e técnicas como o biofeedback vêm sendo utilizadas como terapia isolada ou em combinação para um controle efetivo da dor nesses indivíduos. Além disso, a gravidade dos sintomas tem correlação com fatores de relevância para o prognóstico, como a qualidade de vida, estados emocionais e qualidade do sono. O objetivo deste estudo foi avaliar o efeito da técnica do biofeedback audiovisual no controle da dor e na qualidade do sono em paciente com disfunção temporomandibular muscular. RELATO DO CASO: Paciente do sexo feminino, 34 anos, com disfunção temporomandibular. O critério diagnóstico DC/TMD (Diagnostic Criteria for Temporomandibular Disorders) Eixo I foi aplicado, sendo a paciente classificada com mais de um subtipo de disfunção temporomandibular: mialgia local e dor miofascial com referência, além de cervicalgia como comorbidade. CONCLUSÃO: No caso clínico apresentado a terapia com biofeedback foi efetiva na redução da intensidade da dor e melhoria da qualidade do sono.

ABSTRACT BACKGROUND AND OBJECTIVES: Literature has shown that behavioral and educational modalities are effective options in the treatment of chronic pain, including temporomandibular disorder, and techniques such as biofeedback have been used for single therapy or in combination for effective pain control in these individuals. Furthermore, the severity of symptoms is related to relevant prognostic factors, such as quality of life, emotional states and sleep quality. The aim of the present study was to evaluate the effect of the biofeedback audiovisual technique on pain control and sleep quality in a patient with temporomandibular disorder. CASE REPORT: Female patient, 34 years old, with Temporomandibular Disorder. The DC/TMD (Diagnostic Criteria for Temporomandibular Disorders) Axis I, diagnostic was applied, and the patient was classified with more than one subtype of temporomandibular disorders: local myalgia and myofascial pain with reference, in addition to neck pain as a comorbidity. CONCLUSION: In this case, the biofeedback treatment was effective both in reducing pain intensity and improving sleep quality.

RESUMO Introdução: A opção mais indicada para tratamento da apneia obstrutiva do sono (AOS) é o CPAP; contudo, a aderência é limitada. A Terapia com Aparelho Oral (TAO) é, frequentemente, uma opção, ou mesmo um adjuvante. A prescrição mais utilizada é o Aparelho Oral de avanço mandibular (AOm). O AOm modifica a via aérea superior, melhorando a patência do espaço aéreo. A construção do AOm se baseia no plano de oclusão para desoclusão. No presente estudo, usamos o DIORS®, um AOm diferente, baseado nos conceitos da Reabilitação Neuro-Oclusal (RNO), que utiliza o Plano de Camper como referência da desoclusão para alcançar o equilíbrio neuromuscular e estabilidade funcional. Objetivo: O presente estudo teve como objetivo principal abordar a eficácia do DIORS®, considerando-se os resultados clínicos e polissonográficos. Adicionalmente, foi avaliado, também, se o uso desse AOm é tão eficaz quanto a titulação do CPAP para tratar pacientes com AOS não aderentes ao CPAP. Métodos: Vinte pacientes foram incluídos neste estudo. Dados clínicos objetivos e subjetivos foram avaliados em um laboratório de sono usando polissonografia de noite inteira e a Escala de Sonolência de Epworth (ESE) observando-se três momentos: inicial, titulação do CPAP e usando o DIORS®. Os critérios de sucesso da TAO foram assumidos pela análise dos parâmetros respiratórios como Índice de Apneia e Hipopneia (IAH) e níveis de saturação de oxi-hemoglobina, o índice de despertar e a sonolência diurna. Resultados: Em ambas as terapias, os parâmetros respiratórios e de despertares melhoraram. Adicionalmente, uma melhora na ESE foi alcançada com o DIORS®. Conclusão: Os resultados do presente trabalho apoiam que o DIORS® é uma terapia adjuvante viável e bastante eficaz para pacientes com AOS moderada a grave não aderentes ao CPAP.

ABSTRACT Introduction: The most prescribed treatment option for Obstructive Sleep Apnea (OSA) is CPAP; however, its adherence is limited. Oral Appliance therapy (OAT) is frequently an option or even an adjuvant, being the mandibular advancement Oral Appliance (OAm) the most used prescription. It modifies the upper airway, improving the airway patency. OAm construction is based on the occlusal plane to disocclusion. In this study, the DIORS® appliance was used, a singular OAm, based on Neuro-Occlusal Rehabilitation concepts, that uses Camper’s plane as a disocclusion reference, in order to achieve neuromuscular balance and functional stability. Objective: This study primarily aimed to assess the DIORS® effectiveness in relation to clinical and polysomnographic outcomes. It was also evaluated if the use of DIORS® is as effective as titrated CPAP to treat CPAP non-adherent patients. Methods: Twenty patients were included in this study. Objective and subjective clinical data were assessed at a sleep laboratory using all-night polysomnography, and Epworth Sleepiness Scale (ESS), taken at three moments: Baseline, CPAP titration, and using DIORS®. Analysis of respiratory parameters as apnea/hypopnea index (AHI), oxyhemoglobin saturation levels, the arousal index and daytime sleepiness were taken as criteria for a successful OAT. Results: Respiratory and arousal parameters improved in both therapies, while DIORS® promoted a better ESS. Conclusion: Results from the present work support that DIORS® is a viable and effective adjuvant therapy for patients with moderate to severe OSA non-adherent to CPAP.

RESUMO JUSTIFICATIVA E OBJETIVOS: A síndrome de ardência bucal é um estado disfuncional que afeta o bem-estar físico, mental e social, contribuindo para condições de estresse crônico. Apesar da ausência de dados objetivos, os pacientes experimentam desconforto relacionado à dor com impacto na vida diária. O objetivo deste estudo foi avaliar o impacto da síndrome da boca ardente na percepção da dor e na qualidade de vida. MÉTODOS: Foi realizado um estudo transversal, observacional e caso-controle em 76 indivíduos, 38 em cada grupo, pareados por gênero e idade. Foram utilizados o questionário Oral Health Impact Profile (OHIP-14) para avaliar mudanças na qualidade de vida, a escala analógica visual para o impacto e intensidade da dor e a Pain Catastrophizing Scale (PCS). Foi avaliado também o efeito do sexo, idade e outros fatores de risco associados à síndrome de ardência bucal. RESULTADOS: A idade dos participantes foi de 41 a 85 anos. A síndrome de ardência bucal teve um impacto negativo na qualidade de vida em todas as dimensões dos domínios OHIP-14 e PCS. Cinquenta e oito por cento dos pacientes se queixaram de dor moderada e 42% de dor intensa, enquanto os controles experimentaram apenas dor leve pela escala analógica visual. A prevalência foi predominante no sexo feminino (3:1), e a língua foi o local envolvido mais comum. Menopausa, alterações hormonais e gastrite foram os maiores fatores de risco. CONCLUSÃO: Os pacientes com síndrome de ardência bucal apresentaram escores PCS e OHIP-14 mais altos para todos os domínios, indicando uma interação entre maior carga de percepção da dor e pior qualidade de vida, o que deve ser mais bem avaliado, caracterizado e gerenciado.

ABSTRACT BACKGROUND AND OBJECTIVES: Burning mouth syndrome is a dysfunctional state affecting physical, mental and social welfare, often contributing to chronic stress conditions. Despite the lack of objective data, patients experience pain-related discomfort with impact in their daily life. The objective of this study was to assess the impact of burning mouth syndrome on pain perception and quality of life. METHODS: A cross-sectional, observational, case-controlled study was performed on 76 individuals (38 in each group). The groups were sex- and age-matched. The Oral Health Impact Profile (OHIP-14) questionnaire was used to assess any changes in the quality of life. The visual analog scale was used to assess pain impact and intensity, as well as the Pain Catastrophizing Scale (PCS). The effect of sex and other risk factors associated with burning mouth syndrome were also associated. RESULTS: The age of participants was 41 to 85 years. The patients had a negative impact on quality of life with respect to all dimensions of OHIP-14 and PCS domains. Burning mouth syndrome patients complained about moderate (58%) or intense (42%) pain, while the control group participants experienced only mild pain by visual analog scale. The prevalence was predominant in females (a ratio of 3:1), and the most site involved was the tongue. Menopause, hormonal changes, and gastritis were identified as major risk factors. CONCLUSION: Burning mouth syndrome patients had significantly higher PCS and OHIP-14 scores for all domains, indicating an interaction between a higher burden of pain perception and worse quality of life which should therefore be adequately assessed, characterized and managed.