SUMMARY OBJECTIVE: The aim of this study was to compare the capacity of American Thyroid Association and Thyroid Imaging Reporting and Data System developed by the American College of Radiology in predicting malignancy risk of thyroid nodules and to verify which one is better at avoiding unnecessary fine needle aspiration. METHODS: This was a cross-sectional study with 565 thyroid nodules, followed at a tertiary care hospital, in an iodine-replete area. Those were classified as American Thyroid Association and Thyroid Imaging Reporting and Data System developed by the American College of Radiology systems and stratified according to the Bethesda classification of fine needle aspiration. The values of sensibility, specificity, positive predictive value, and negative predictive value accuracy were calculated. Also, the percentage of unnecessary biopsies was presented. RESULTS: The mean age of the individuals was 58.2±13.5 [26–90] years for benign nodules and 41.7±15.6 [23–66] years for malignant nodules (p=0.002). Regarding gender, 92.6% (n=150) of the individuals with benign nodules and 85.7% (n=06) with malignant nodules were females (p=0.601). For American Thyroid Association, 90.9% of sensibility, 51.4% of specificity, 52.6% of accuracy, 10.2% of positive predictive value, and 98.9% of negative predictive value were found. For Thyroid Imaging Reporting and Data System developed by the American College of Radiology, 90.9% of sensibility, 49.7% of specificity, 52.1% of accuracy, 9.9% of positive predictive value, and 98.9% of negative predictive value were found. .Notably, 12.3% of unnecessary fine needle aspiration were found in American Thyroid Association and 44.4% were found in Thyroid Imaging Reporting and Data System developed by the American College of Radiology. CONCLUSION: Both Thyroid Imaging Reporting and Data System developed by the American College of Radiology and American Thyroid Association are able to predict the malignancy risk of thyroid nodules. Thyroid Imaging Reporting and Data System developed by the American College of Radiology was better at avoiding unnecessary fine needle aspiration. OBJECTIVE METHODS crosssectional cross sectional 56 hospital iodinereplete iodine replete area sensibility specificity calculated Also presented RESULTS 582135 58 2 13 5 58.2±13. 26–90 2690 26 90 [26–90 417156 41 7 15 6 41.7±15. 23–66 2366 23 66 [23–66 p=0.002. p0002 p p=0.002 . 0 002 (p=0.002) gender 926 92 92.6 n=150 n150 n 150 (n=150 857 85 85.7 n=06 n06 06 (n=06 p=0.601. p0601 p=0.601 601 (p=0.601) 909 9 90.9 514 51 4 51.4 526 52 52.6 102 10 10.2 989 98 98.9 497 49 49.7 521 1 52.1 99 9.9 Notably .Notably 123 12 3 12.3 444 44 44.4 CONCLUSION 58213 58.2±13 26–9 269 [26–9 41715 41.7±15 23–6 236 [23–6 p000 p=0.00 00 (p=0.002 92. n=15 n15 (n=15 8 85. n=0 n0 (n=0 p060 p=0.60 60 (p=0.601 90. 51. 52. 10. 98. 49. 9. 12. 44. 5821 58.2±1 26– [26– 4171 41.7±1 23– [23– p00 p=0.0 (p=0.00 n=1 n1 (n=1 n= (n= p06 p=0.6 (p=0.60 582 58.2± [26 417 41.7± [23 p0 p=0. (p=0.0 (n (p=0.6 58.2 [2 41.7 p=0 (p=0. 58. [ 41. p= (p=0 (p= (p

RESUMO Objetivo: Conhecer as evidências disponíveis na literatura sobre os efeitos do vírus zika no desenvolvimento infantil pós-exposição no período fetal. Métodos: Trata-se de uma revisão integrativa da literatura com 16 artigos científicos encontrados em cinco bases de dados (PubMed, LILACS, CINAHL, Web of Science e Scopus), com base na pergunta norteadora: “Quais os efeitos no desenvolvimento de crianças de 0 a 6 anos de idade expostas ao vírus zika no período fetal?” Para a extração dos dados e avaliação dos estudos primários, utilizou-se a declaração STROBE. Resultados: A exposição ao vírus zika no período fetal resultou em diversas anomalias congênitas e/ou alterações no sistema nervoso central: microcefalia, problemas oculares, neurosensoriais, ventriculomegalia, calcificação intracraniana, cardiopatia, artrogripose, dentre outras. Conclusão: O vírus zika é neurotrópico; seu efeito no produto fetal causa danos irreparáveis à criança, portanto profissionais da saúde, em especial os enfermeiros, devem intensificar o cuidado materno-infantil.

ABSTRACT Objective: To know the evidence available in the literature on the effects of the zika virus in children development after fetal exposure. Methods: This is an integrative literature review with 16 scientific articles found in five databases (PubMed, LILACS, CINAHL, Web of Science and Scopus), based on the guiding question: “What are the effects in the development of children aged 0 to 6 years exposed to the zika virus in the fetal period? The STROBE statement was used for data extraction and evaluation of primary studies. Results: Exposure to the zika virus in the fetal period resulted in several congenital anomalies and/or changes in the central nervous system: microcephaly, ocular problems, neurosensorial problems, ventriculomegaly, intracranial calcification, cardiopathy, arthrogryposis, among others. Conclusion: The zika virus is neurotropic; its effect in the fetal nervous system causes irreparable damage to the child, so health professionals, especially nurses, must intensify maternal and also childcare.

RESUMEN Objetivo: Conocer las evidencias disponibles en la literatura sobre los efectos del virus zika en el desarrollo infantil postexposición en el período fetal. Método: Se trata de una revisión integrativa de la literatura con 16 artículos científicos encontrados en cinco bases de datos (PubMed, LILACS, CINAHL, Web of Science y Scopus), basada en la interrogación: “¿Cuáles los efectos en el desarrollo de niños de 0 a 6 años expuestos al virus zika en el período fetal?” Para extracción de datos y evaluación de estudios primarios, se utilizó la declaración STROBE. Resultados: La exposición al virus zika en el período fetal resultó en diversas anomalías congénitas y/o alteraciones en sistema nervioso central: microcefalia, problemas oculares, neurosensoriales, ventriculomegalia, calcificación intracraneal, cardiopatía, artrogriposis, etcétera. Conclusión: El virus zika es neurotrópico; su efecto en el producto fetal causa daños irreparables al niño, luego profesionales de salud, especialmente los enfermeros, deben intensificar el cuidado materno-infantil.

ABSTRACT Objective: To know the evidence available in the literature on the effects of the zika virus in children development after fetal exposure. Methods: This is an integrative literature review with 16 scientific articles found in five databases (PubMed, LILACS, CINAHL, Web of Science and Scopus), based on the guiding question: “What are the effects in the development of children aged 0 to 6 years exposed to the zika virus in the fetal period? The STROBE statement was used for data extraction and evaluation of primary studies. Results: Exposure to the zika virus in the fetal period resulted in several congenital anomalies and/or changes in the central nervous system: microcephaly, ocular problems, neurosensorial problems, ventriculomegaly, intracranial calcification, cardiopathy, arthrogryposis, among others. Conclusion: The zika virus is neurotropic; its effect in the fetal nervous system causes irreparable damage to the child, so health professionals, especially nurses, must intensify maternal and also childcare.

RESUMEN Objetivo: Conocer las evidencias disponibles en la literatura sobre los efectos del virus zika en el desarrollo infantil postexposición en el período fetal. Método: Se trata de una revisión integrativa de la literatura con 16 artículos científicos encontrados en cinco bases de datos (PubMed, LILACS, CINAHL, Web of Science y Scopus), basada en la interrogación: “¿Cuáles los efectos en el desarrollo de niños de 0 a 6 años expuestos al virus zika en el período fetal?” Para extracción de datos y evaluación de estudios primarios, se utilizó la declaración STROBE. Resultados: La exposición al virus zika en el período fetal resultó en diversas anomalías congénitas y/o alteraciones en sistema nervioso central: microcefalia, problemas oculares, neurosensoriales, ventriculomegalia, calcificación intracraneal, cardiopatía, artrogriposis, etcétera. Conclusión: El virus zika es neurotrópico; su efecto en el producto fetal causa daños irreparables al niño, luego profesionales de salud, especialmente los enfermeros, deben intensificar el cuidado materno-infantil.

RESUMO Objetivo: Conhecer as evidências disponíveis na literatura sobre os efeitos do vírus zika no desenvolvimento infantil pós-exposição no período fetal. Métodos: Trata-se de uma revisão integrativa da literatura com 16 artigos científicos encontrados em cinco bases de dados (PubMed, LILACS, CINAHL, Web of Science e Scopus), com base na pergunta norteadora: “Quais os efeitos no desenvolvimento de crianças de 0 a 6 anos de idade expostas ao vírus zika no período fetal?” Para a extração dos dados e avaliação dos estudos primários, utilizou-se a declaração STROBE. Resultados: A exposição ao vírus zika no período fetal resultou em diversas anomalias congênitas e/ou alterações no sistema nervoso central: microcefalia, problemas oculares, neurosensoriais, ventriculomegalia, calcificação intracraniana, cardiopatia, artrogripose, dentre outras. Conclusão: O vírus zika é neurotrópico; seu efeito no produto fetal causa danos irreparáveis à criança, portanto profissionais da saúde, em especial os enfermeiros, devem intensificar o cuidado materno-infantil.