Combining direct targeting, enhanced cellular uptake, photothermal transduction capacity, and biocompatibility in the same system is a challenge to make the application of nanoparticles in biomedicine real. This study involves the functionalization of gold nanoparticles (AuNPs) in a few steps with strategic macromolecules to provide characteristics that are key to theragnostic agents. Polyethylene glycol (PEG) is hydrophilic and can improve nanoparticle stability and circulation lifetime. Polylactic acid (PLA) is a biodegradable hydrophobic polymer important to guarantee the interaction and uptake through the cellular membranes. Folate provides specific targeting because tumors usually overexpress folate receptor proteins. Single, double, and triple functionalization of spherical and rodlike AuNPs with these ligands provided different aggregation, stability, and plasmonic properties. Triple functionalization ensured simultaneous nanoparticle stability in an aqueous medium and enhanced cellular uptake. Infrared irradiation increased the temperature of gold nanorods more than of gold nanospheres due to the longitudinal surface plasmon resonance band. The results suggest that this functionalization strategy can be used to tune the desired properties for applications of gold nanoparticles, such as imaging and photothermal therapy in biomedicine research. capacity real (AuNPs agents PEG (PEG lifetime PLA (PLA membranes proteins Single double aggregation band research

ABSTRACT Most Brazilian municipalities do not have regulated areas for solid waste disposal in civil construction. Usually, residues are disposed of vacant lots and dumps, posing risks to the population health and the environment. Soils are the primary means for the disposal or recycling of waste, highlighting the importance of well-characterized soils and their respective landscape. This study aimed to establish a land suitability system for solid residues in civil construction and apply such information in a case study in Southeastern Brazil. An unprecedented digital soil map with a resolution of 30 m was created using the random forest classifier algorithm and soil field prospection information. A guide listing favorable soil-landscape attributes that most prevent soil erosion, water bodies or water table contamination was elaborated and discussed. Thus, such information was linked through a suitability system to classify areas with potential for receiving waste on a daily volume basis as follows: large size: >500 m³ day-1, medium size: >100 m³ day-1 and <300 m³ day-1, and small size <100 m³ day-1. Topography and soil depth were the most limiting factors of the areas in the case study. The proposed attributes as criteria for the suitability system complement the current state legislation. A total of 236 ha closer to the urban perimeter connected by roads in good condition were classified as suitable for managing medium- and small-scale daily volume, whose destination might reduce transportation and installation costs in the study area. Usually dumps environment wellcharacterized well characterized landscape Brazil 3 soillandscape erosion discussed Thus follows 500 >50 day1, day1 day 1, 1 100 >10 day- 300 <30 <10 day1. 1. legislation 23 smallscale scale area 50 >5 10 >1 <3 <1 2 5 > <

Abstract Acai (Euterpe oleracea Mart.) and guarana (Paullinia cupana Kunth) are native species from the Amazon Forest that in folk medicine are used to treat several diseases due to their anti-inflammatory and antioxidant properties. This review brings together findings from different studies on the potential neuroprotective effects of acai and guarana, highlighting the importance of the conservation and sustainable exploitation of the Amazon Forest. A bibliographic survey in the PubMed database retrieved indexed articles written in English that focused on the effects of acai and guarana in in vitro and in vivo models of neurodegenerative diseases. In general, treatment with either acai or guarana decreased neuroinflammation, increased antioxidant responses, ameliorated depression, and protected cells from neurotoxicity mediated by aggregated proteins. The results from these studies suggest that flavonoids, anthocyanins, and carotenoids found in both acai and guarana have therapeutic potential not only for neurodegenerative diseases, but also for depressive disorders. In addition, acai and guarana show beneficial effects in slowing down the physiological aging process. However, toxicity and efficacy studies are still needed to guide the formulation of herbal medicines from acai and guarana. Euterpe Mart. Mart Paullinia Kunth antiinflammatory anti inflammatory properties general neuroinflammation responses depression proteins flavonoids anthocyanins disorders addition process However

RESUMO Há muita informação sobre a associação de Psocoptera e café como peste em grãos armazenados, mas pouco se sabe sobre sua presença nas plantas do café. Nós realizamos uma amostragem em uma plantação de café de Coffea canephora no município de Candeias do Jamari, Rondônia, onde obtivemos o primeiro registro de uma planta de café como hospedeira de Psocoptera na Amazônia brasileira e o primeiro registro de um representante da família Archipsocidae (Archipsocus lenkoi) para o estado de Rondônia. A população de psocídeos estava concentrada e não distribuída uniformemente na área de amostragem, o que indica um padrão de distribuição irregular. Não detectamos danos ou injúrias nas plantas de café e, portanto, não podemos considerar esses psocídeos como uma praga na plantação de café.

ABSTRACT There is much information regarding the association of Psocoptera and coffee as stored grain pests and little is known about their presence in coffee plants. We conducted a survey in a coffee plantation of Coffea canephora in the municipality of Candeias do Jamari, Rondônia state, Brazil, where we obtained the first record of a coffee plant as a host of Psocoptera in the Brazilian Amazon region, and the first record of a representative of the family Archipsocidae (Archipsocus lenkoi) for the state of Rondônia. The psocid population was concentrated and not evenly distributed over the survey area, which indicates an irregular distribution pattern. We have not detected damage or injury to the coffee plants and therefore we cannot consider these psocids as a pest in the coffee plantation.

Resumen Este estudio tiene como objetivo verificar la participación del incentivo fiscal otorgado a las empresas en el crecimiento del ingreso per cápita de Maranhão. Los programas analizados fueron: "PróMaralhão" y "Mais Empresas” y el período verificado fue entre 2010 y 2017. La metodología utilizada fue el análisis de datos sobre los efectos de los incentivos fiscales en la generación de empleo e ingresos del Producto Interno Bruto (PIB) producción per cápita disponible en los sitios web: Instituto Maranhense de Estudios Socioeconómicos y Cartográficos (IMESC), Instituto Brasileño de Geografía y Estadística (IBGE) e Instituto de Investigación de Economía Aplicada (IPEA). Los principales resultados son una relación positiva entre el crecimiento del empleo y los ingresos en el estado de Maranhão, y que la política adoptada por el gobierno en la concesión de incentivos fiscales, a través de los programas PróMarhões y Mais Empresas, ha contribuido al crecimiento económico, por lo tanto, ha generado algún desarrollo social y económico para sus ciudadanos.

Abstract This study aims to verify the participation of the tax incentive granted to companies in the growth of per capita income in Maranhão. The programs analyzed were: “PróMaralhão” and “Mais Empresas” and the period verified was between 2010 and 2017. The methodology used was the analysis of data on the effects of tax incentives on the generation of employment and income from the Gross Domestic Product (GDP)) production, per capita available on the websites: Instituto Maranhense de Socioeconomic and Cartographic Studies (IMESC), Brazilian Institute of Geography and Statistics (IBGE) and Institute of Applied Economics Research (IPEA). The main results are a positive relationship between the growth of employment and income in the state of Maranhão, and that the policy adopted by the government in the granting of tax incentives, through the PróMarhões and Mais Empresas programs has contributed to economic growth, consequently, has generated some social and economic development for its citizens.

RESUMEN Bixa orellana L. es ampliamente utilizado como un tinte y tiene otras propiedades que han sido poco estudiadas, especialmente en relación con las hojas. Este artículo evalúa cómo el secado B. orellana L. influye en las propiedades de los aceites esenciales (EOs) extraídos de sus hojas. El material vegetal recogido se sometió al horno de secado por aire convectivo a temperaturas de 35, 45 y 55 °C. Los perfiles químicos fueron determinados por GC-MS. Se aplicaron modelos matemáticos para representar el proceso de secado y el análisis estadístico realizado utilizando el software Statistica 10. Las EO se obtuvieron a través de la técnica de hidrodestilación con verificación de propiedades fisicoquímicas y actividad antimicrobiana. Para el ensayo de toxicidad se aplicó el bioensayo a Artemia salina. A través de los resultados obtenidos fue posible determinar el modelo matemático que se ajustaba mejor. Se observaron diferencias significativas en las propiedades de los EO. La temperatura de 45 °C permitió obtener el mejor rendimiento de EO, porque la actividad antimicrobiana fue más eficiente. Este estudio afirma a través de las actividades analizadas que la temperatura de secado influye en las propiedades fisicoquímicas y biológicas de las EO. Estudios como este evalúan el mejor modelo matemático para predecir el secado, así como las temperaturas específicas que influyen en las propiedades del producto obtenido.

SUMMARY Bixa orellana L. is widely used as a dye, and other properties are still little studied, especially in relation to leaves. This article evaluates how drying B. orellana L. influences the properties of essential oils (EOs) extracted from their leaves. The collected plant material was submitted to convective air-drying oven at temperatures of 35, 45 and 55 °C. Chemical profiles were determined by Gas Chromatography-Mass Spectrometry (GC-MS). Mathematical models were applied to represent the drying process and statistical analysis performed using Statistica 10 software. The EO's were obtained through the hydrodistillation technique with verification of physicochemical properties and antimicrobial activity by the Disc Diffusion Method. For the toxicity test, the bioassay was applied to Artemia salina. Through the results obtained it was possible to determine that the mathematical model of Verma was the one that best fitted the experimental data. Significant differences in the properties of EO's were observed. The temperature of 45 °C allowed obtaining the best EO yield, still presenting the most efficient antimicrobial activity. This study states through the activities analyzed that the drying temperature influences the physicochemical and biological properties of the EO's, thus requiring studies such as this one that evaluate the best mathematical model to predict drying as well as the specific temperatures that influence the properties of the product obtained.

ABSTRACT Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease characterized by multisystem involvement such as bone, muscle, endocrine, ophthalmologic, cardiovascular, central and peripheral nervous system, cognitive capacity, voice, and oral motor disorders. Nutritional studies in individuals with NF1 have been performed recently. While a previous study showed an inadequate nutrient intake in patients with NF1, the dietary patterns of this population have not yet been widely studied. This study aimed to characterize dietary patterns in Brazilian adults with NF1. Sixty NF1 individuals (51.7% women), ≥18 years of age underwent nutritional assessment including laboratory analysis, anthropometrics, and eating habits recorded on a food frequency questionnaire. Cluster analysis was used to distinguish between dietary patterns. Hypothesis tests were used to compare data. Two groups with distinct patterns were identified, “Healthy” (46.7%) and “Western” (53.3%). These groups were similar in most of the socioeconomic, anthropometric, demographic and laboratory parameters evaluated. However, the upper-arm total area and upper-arm muscle area (UAMA) were lower in the Western group than those in the Healthy group [59.8 (25.7) cm2 versus 65.6 (28.3) cm2, P=0.049; 35.6±12.4 cm2 versus 43.8±15.0 cm2, P=0.024, respectively]. In this study, most individuals with NF1 had a Western dietary pattern and this group showed a lower UAMA, which may indicate a potential contribution, even in part, of diet in the muscle phenotype in this population. This association between diet and muscle in NF1 individuals requires investigation in further studies.

RESUMEN La neurofibromatosis tipo 1 (NF1) es una enfermedad genética autosómica dominante caracterizada por la afectación multisistémica, alterando los sistemas óseo, muscular, endocrino, oftálmico, cardiovascular, nervioso central y periférico así como las capacidades cognitivas. Un estudio previo señaló una ingesta inadecuada de nutrientes en pacientes con NF1, pero los patrones dietéticos de esta población aún no han sido estudiados ampliamente. El objetivo de este est udio es caracterizar los patrones dietéticos en brasileños con NF1. Sesenta individuos con NF1 (51,7% mujeres) ≥18 años se sometieron a una evaluación nutricional que incluyeron análisis de laboratorio, antropometría y hábitos alimentarios registrados en un cuestionario de frecuencia alimentaria. El análisis de conglomerados se utilizó para distinguir los patrones dietéticos; las pruebas de hipótesis para comparar datos. Se identificaron dos grupos con patrones distintos, denominados Saludables (46,7%) y Occidentales (53,3%). Estos grupos fueron similares en la mayoría de los parámetros socioeconómicos, antropométricos, demográficos y de laboratorio evaluados. Sin embargo, las áreas total braquial (ATB) y muscular braquial (AMB) fueron menores en el grupo occidental que en el grupo sano [59,8 (25,7) cm2 y 65,6 (28,3) cm2, P= 0,049; 35,6 ± 12,4 cm2 y 43,8 ± 15,0 cm2, P= 0,024, respectivamente]. En este estudio, la mayoría de las personas con NF1 habían consumido un patrón dietético occidental y este grupo presentó un AMB menor, lo que puede indicar una contribución potencial, incluso en parte, de la dieta en el fenotipo muscular en esta población. Esta asociación entre dieta y músculo en personas con NF1 requiere investigaciones en estudios adicionales.

RESUMEN Objetivo: presentar el proceso de construcción y validación de un instrumento para evaluar el saber y el quehacer de enfermeros en los cuidados paliativos hacia la persona con herida tumoral maligna cutánea. Materiales y método: estudio metodológico, cuantitativo, con aplicación de la técnica Delphi, realizada en dos etapas. La primera se realizó con 30 jueces y la segunda, con 17. Para el análisis, se emplearon coeficiente de Lambda 2 Guttman, índice Kappa y Índice de Validez de Contenido (IVC). Resultados: de los 112 ítems del instrumento original, 28 fueron excluidos, pues los porcentuales de Lambda 2 Guttman, el Kappa y el IVC presentaron indicadores menores que el aceptable; así, la segunda versión del instrumento resultó en 84 ítems, lo que presentó aceptación en 100 % en la fase Delphi 2. Conclusiones: a partir de la evaluación de los jueces, se definió una versión del instrumento con índice de concordancia y validez de contenido adecuados, que podrá aportar a la evaluación del saber y del quehacer de enfermeros en los cuidados paliativos hacia la persona con herida tumoral maligna cutánea.

ABSTRACT Objective: To present the construction and validation process of an instrument to evaluate the knowledge and practice of nurses in palliative care toward the person with cutaneous malignant tumor wound. Materials and Methods: Methodological, quantitative study with applying the Delphi technique, conducted in two stages. The first was carried out with 30 judges and the second with 17. The analysis used the Lambda 2 Guttmann coefficient, Kappa index, and Content Validity Index (CVI). Results: Of the 112 items of the original instrument, 28 were excluded, given that the percentiles of Lambda 2 Guttmann, Kappa, and CVI had indicators lower than acceptable; thus, the second version of the instrument resulted with 84 items, which presented 100 % acceptance in the Delphi 2 phase. Conclusions: From the evaluation by the judges, a version of the instrument was defined with adequate content validity and concordance indices, which could contribute to the evaluation of knowledge and practice of nurses in palliative care toward the person with cutaneous malignant tumor wound.

RESUMO Objetivo: apresentar o processo de construção e validação de um instrumento para avaliar o saber e o fazer de enfermeiros nos cuidados paliativos destinados à pessoa com ferida tumoral maligna cutânea. Materiais e método: estudo metodológico, quantitativo, com aplicação da técnica Delphi, realizada em duas etapas. A primeira realizada com 30 juízes; a segunda, com 17. Para a análise, utilizaram-se o coeficiente de Lambda 2 Guttman, o índice Kappa e o Índice de Validade de Conteúdo (IVC). Resultados: dos 112 itens do instrumento original, 28 foram excluídos, pois os percentuais de Lambda 2 Guttman, o Kappa e o IVC apresentaram escores menores do que o aceitável; desse modo, a segunda versão do instrumento resultou em 84 itens, o qual apresentou aceitação em 100 % na fase Delphi 2. Conclusões: a partir da avaliação dos juízes, foi definida uma versão do instrumento com índice de concordância e validade de conteúdo adequados, que poderá contribuir para a avaliação do saber e do fazer de enfermeiros nos cuidados paliativos destinados à pessoa com ferida tumoral maligna cutânea.

RESUMO: Há séculos, populações de plantas vem sendo selecionadas a fim de se obter linhagens com maior desempenho agronômico. Para o sucesso da seleção, a variabilidade genética é essencial, sendo que dentro do gênero Passiflora há grande variabilidade inter e intraespecífica. Neste trabalho, objetivou-se avaliar as características físicas de frutos de genótipos elite de maracujazeiro-doce (Passiflora alata) para fins de seleção. Foram avaliadas a massa, diâmetros longitudinal e equatorial de frutos, espessura e coloração da casca e massa e volume de polpa com e sem sementes e rendimentos de polpa. As fontes de variação para análise de variância foram os frutos de oito genótipos elite, com três repetições, cujas médias foram comparadas pelo teste de Tukey a 1% de probabilidade. Foram realizadas ainda análises multivariadas e de correlação entre as características. Houve diferenças estatísticas entre os genótipos elite para a maioria das características avaliadas. O genótipo elite sete foi o que apresentou maior rendimento de polpa sem sementes, em relação ao fruto e maior massa de fruto. Análises de agrupamento e dispersão gráfica evidenciaram uma tendência de agrupamento dos genótipos elite com base no formato dos frutos. A população apresenta variabilidade genética, que permite novos ciclos de seleção para ganho em rendimento de polpa e massa dos frutos.

ABSTRACT: Over several past centuries, specific plant populations have been carefully selected to filter strains with higher agronomic performance. Genetic variability is most essential for successful selection. The Passiflora genus offers great inter- and intra-specific variability. This study aimed to evaluate the physical characteristics of the genotypes of the elite passion fruit (Passiflora alata) for selection purpose. We considered the physical traits of fruit mass, longitudinal and equatorial diameters, peel thickness and color, and pulp mass and volume without and with seeds and pulp yield. The sources of variation for the analysis of variance included the fruits of 8 elite genotypes, with 3 replications, whose means were compared by Tukey’s test at 1% probability. We also performed multivariate analysis and correlation between these characteristics. Statistical differences were noted between elite genotypes for most of the tested traits. The elite 7 genotype presented with the highest seedless pulp yield in relation to the fruit and the largest fruit mass. Cluster analysis and graphic dispersion revealed a tendency for clustering of the elite genotypes based on their fruit shape. The tested population showed genetic variability, which allowed new selection cycles toward gaining pulp yield and fruit mass.

Resumo O maracujá-doce (Passiflora alata Curtis) produz frutos comercializados para consumo in natura com aroma agradável, baixa acidez e elevados teores de sólidos solúveis totais. Objetivou-se com este trabalho avaliar aspectos físico-químicos de frutos obtidos dos diferentes genótipos de P. alata. Foram avaliados os frutos de 14 genótipos previamente selecionados. Avaliaram-se o rendimento de polpa com e sem sementes, a composição química, teores de potássio e de sódio, pH, acidez total titulável, teor de sólidos solúveis totais, ratio, teores de compostos fenólicos e de flavonoides e cor. O experimento foi delineado em blocos casualizados (DBC) com quatro repetições. Foi realizada análise de variância e posteriormente teste de Scott-Knott, a 5% de probabilidade. Os genótipos 2, 5, 6, 7, 11, 13 e 14 se destacaram pelos maiores valores de ratio, sendo superiores a 11,0. Por outro lado, os genótipos 2, 3, 5, 7, 8, 9, 11, 12 e 13 apresentaram rendimento de polpa com semente acima de 18,0%. No que se refere aos compostos bioativos, destacaram-se os genótipos 1 e 7, em função dos teores de compostos fenólicos e de flavonoides, respectivamente. Os genótipos, obtidos a partir das seleções, demonstram a alta variabilidade na composição química da polpa e no conjunto de aspectos físicos e químicos do maracujá-doce.

Abstract Sweet passion fruit (Passiflora alata Curtis) produce fruits that are marketed for in natura consumption with pleasant aroma, low acidity and high soluble solids content. The objective of this work was to evaluate the physicochemical aspects of fruits obtained from different genotypes of P. alata. Fruits of 14 previously selected genotypes were evaluated. The pulp yield with and without seeds, chemical composition, potassium and sodium contents, pH, total titratable acidity, total soluble solids content, ratio, total phenolic and flavonoid contents and color were evaluated. The experiment was a randomized complete block design (RCBD) with four replicates. The variance analysis and the Scott-Knott test were performed at 5% probability. The genotypes 2, 5, 6, 7, 11, 13 and 14 were highlighted by the highest ratio values, being higher than 11.0. On the other hand, genotypes 2, 3, 5, 7, 8, 9, 11, 12 and 13 presented pulp yield with seed higher than 18.0%. As regards bioactive compounds, genotypes 1 and 7 were highlighted, as a function of the total phenolic and flavonoid contents, respectively. The genotypes, obtained from the selections, demonstrate the high variability in the chemical composition of the pulp and in the physical and chemical aspects of sweet passion fruit.

Abstract Amazonian Robustas are ten new clones of high yield potential with characteristics typical of the botanical varieties conilon and robusta. With individual registration, the new cultivars were developed to be grown together with other clones, with flexibility of composition of the crops according to the preference of the producer.

RESUMEN Este artículo pretende emprender un análisis de las regulaciones legales del mercado capital brasileño apoyado por investigación bibliográfica y evaluación documental y de datos; enmarcada en la revisión del instrumento regulatorio conocido como acuerdo extrajudicial (conciliación). Un total de 405 términos fueron aprobados por Comisión Brasileña de Bolsas y Valores (CVM) entre el 2009 y el 2014, lo cual caracteriza un amplio uso de este instrumento regulatorio. Este análisis concluye que aunque el arreglo presentado acá puede ser reconocido como un importante mecanismo en el contexto de la regulación del mercado de capitales, su uso excesivo constituye una distorsión tanto de sus propósitos como de los fundamentos de la normativa disciplinaria del mercado e incluso del conjunto de funciones asignadas al CVM.

ABSTRACT The main purpose of this paper is to analyze the legal regulation of the Brazilian capital market, through literature research and assessment of documents and data, with focus on the revision of the regulatory instrument known as consent decree (settlement). A total number of 405 terms were approved by the Brazilian Securities and Exchange Commission (CVM) between 2009 and 2014, characterizing a wide use of such regulatory instrument. The present analysis concluded that, although the settlement is considered an important mechanism in the context of capital market regulation, its excessive use constitutes a distortion of both its purposes and of the foundations of normative discipline of the market, and even of the set of functions assigned to the CVM.

RESUMO Este artigo visa desenvolver uma análise da regulação legal do mercado de capitais brasileiro, apoiada por pesquisa de literatura e avaliação de documentos e dados, com foco na revisão do instrumento regulatório chamado “termo de compromisso”. Um total de 405 termos foram aprovados pela Comissão de Valores Mobiliários (CVM) entre 2009 e 2014, que caracteriza um amplo uso desse instrumento regulatório. A presente análise concluiu que, embora o acordo apresentado neste documento possa ser reconhecido como um importante mecanismo no contexto da regulação do mercado de capitais, seu uso excessivo constitui uma distorção de ambos os seus propósitos e das fundações de disciplina normativa no mercado, e ainda de um conjunto de funções designadas à CVM.

The object of this study was to analyse the impact of the practice of physical activity on the body mass index (BMI) and self-esteem of adolescents. The samples included 1,011 adolescents, aged between 14 and 18 years. First the BMI was calculated, then the adolescents filled in the Rosenberg Self-esteem Scale (RSS) questionnaire and the International Physical Activity Questionnaire (IPAQ). Student's t-test and the chi-squared test were used for statistical analysis. The Odds Ratio and the Confidence Interval (95%) were also calculated. Female adolescents who are physically active have a 22.4% lower probability of developing overweight/obesity (OR=0.776, CI 95% 0.741-0.813) and 34.4% lower probability of presenting low self-esteem (OR=0.656, CI 95% 0.616-0.698). Participation in physical education classes reduces the probability that male adolescents will present low self-esteem by 88% (OR=0.120 CI 95% 0.043-0.339). In female adolescents, the practice of physical activity at school acts to prevent low self-esteem, as well as helping to control bodyweight increase. In male adolescents’ participation in physical education classes acts as a protection against low self-esteem.

RESUMO Objetivo: Analisar o conceito de Aprendizagem Significativa, conforme a Teoria de David Ausubel. Método: Revisão integrativa, utilizando o modelo de análise teórica de Meleis. Resultados: Foram identificados como antecedentes: Conhecimentos prévios dos alunos, material instrucional potencialmente significativo e disposição do aluno para aprender. Os atributos encontrados foram: Existência de conhecimentos prévios que possibilite a conexão com o novo conhecimento; interação de conhecimentos prévios e novos na estrutura cognitiva; ampliação da estrutura cognitiva por meio da incorporação do conhecimento prévio com o novo. Os consequentes encontrados: Existência de novos conhecimentos na estrutura cognitiva do aluno, que geram sentido e significado no sistema cognitivo do aluno e que lhe confere importância conforme a utilidade para sua vida cotidiana. Conclusão: A análise conceitual realizada contribuiu com a instituição de uma definição mais completa para a Aprendizagem Significativa, que poderá ser apreciada no ensino e na pesquisa, independentemente de área de atuação.

ABSTRACT Objective: To analyze the concept of Meaningful Learning, according to David Ausubel's Theory. Method: Integrative review using the Meleis's Theoretical Analysis model. Results: The following were identified as antecedents: Previous students' knowledge, potentially meaningful instructional material and student's willingness to learn. The attributes found were: Existence of previous knowledge that allows the connection with the new knowledge; interaction of previous and new knowledge in the cognitive structure; expansion of the cognitive structure through the incorporation of prior knowledge with the new. The consequent ones found: Existence of new knowledge in the cognitive structure of the student, that generate sense and meaning in the cognitive system of the student and that confers importance to him according to the utility for his daily life. Conclusion: The conceptual analysis carried out contributed to the establishment of a more complete definition for Meaningful Learning, which can be appreciated in teaching and research, regardless of the area of activity.

RESUMEN Objetivo: analizar el concepto de Aprendizaje Significativo, conforme a la Teoría de David Ausubel. Método: revisión integrativa, utilizando el modelo de análisis teórico de Meleis. Resultados: se identificaron como antecedentes: los conocimientos previos de los alumnos, el material instructivo potencialmente significativo y la disposición del alumno para aprender. Los atributos encontrados fueron: la existencia de conocimientos previos que posibiliten la conexión con el nuevo conocimiento; la interacción de conocimientos previos y nuevos en la estructura cognitiva; la ampliación de la estructura cognitiva por medio de la incorporación del conocimiento previo con lo nuevo. Los consecuentes encontrados fueron: la existencia de nuevos conocimientos en la estructura cognitiva del alumno, que generan sentido y significado en el sistema cognitivo del alumno y que le confiere importancia según la utilidad para su vida cotidiana. Conclusión: el análisis conceptual realizado contribuyó con la institución de una definición más completa para el Aprendizaje Significativo, que podrá ser apreciada en la enseñanza y en la investigación, independientemente del área de actuación.

ABSTRACT Objective: To analyze the concept of Meaningful Learning, according to David Ausubel's Theory. Method: Integrative review using the Meleis's Theoretical Analysis model. Results: The following were identified as antecedents: Previous students' knowledge, potentially meaningful instructional material and student's willingness to learn. The attributes found were: Existence of previous knowledge that allows the connection with the new knowledge; interaction of previous and new knowledge in the cognitive structure; expansion of the cognitive structure through the incorporation of prior knowledge with the new. The consequent ones found: Existence of new knowledge in the cognitive structure of the student, that generate sense and meaning in the cognitive system of the student and that confers importance to him according to the utility for his daily life. Conclusion: The conceptual analysis carried out contributed to the establishment of a more complete definition for Meaningful Learning, which can be appreciated in teaching and research, regardless of the area of activity.

RESUMEN Objetivo: analizar el concepto de Aprendizaje Significativo, conforme a la Teoría de David Ausubel. Método: revisión integrativa, utilizando el modelo de análisis teórico de Meleis. Resultados: se identificaron como antecedentes: los conocimientos previos de los alumnos, el material instructivo potencialmente significativo y la disposición del alumno para aprender. Los atributos encontrados fueron: la existencia de conocimientos previos que posibiliten la conexión con el nuevo conocimiento; la interacción de conocimientos previos y nuevos en la estructura cognitiva; la ampliación de la estructura cognitiva por medio de la incorporación del conocimiento previo con lo nuevo. Los consecuentes encontrados fueron: la existencia de nuevos conocimientos en la estructura cognitiva del alumno, que generan sentido y significado en el sistema cognitivo del alumno y que le confiere importancia según la utilidad para su vida cotidiana. Conclusión: el análisis conceptual realizado contribuyó con la institución de una definición más completa para el Aprendizaje Significativo, que podrá ser apreciada en la enseñanza y en la investigación, independientemente del área de actuación.

RESUMO Objetivo: Analisar o conceito de Aprendizagem Significativa, conforme a Teoria de David Ausubel. Método: Revisão integrativa, utilizando o modelo de análise teórica de Meleis. Resultados: Foram identificados como antecedentes: Conhecimentos prévios dos alunos, material instrucional potencialmente significativo e disposição do aluno para aprender. Os atributos encontrados foram: Existência de conhecimentos prévios que possibilite a conexão com o novo conhecimento; interação de conhecimentos prévios e novos na estrutura cognitiva; ampliação da estrutura cognitiva por meio da incorporação do conhecimento prévio com o novo. Os consequentes encontrados: Existência de novos conhecimentos na estrutura cognitiva do aluno, que geram sentido e significado no sistema cognitivo do aluno e que lhe confere importância conforme a utilidade para sua vida cotidiana. Conclusão: A análise conceitual realizada contribuiu com a instituição de uma definição mais completa para a Aprendizagem Significativa, que poderá ser apreciada no ensino e na pesquisa, independentemente de área de atuação.