Resumo Objetivou-se realizar uma análise espacial da taxa de mortalidade hospitalar (TMH) por síndrome respiratória aguda grave (SRAG) atribuída à COVID-19 em crianças e adolescentes no Brasil no período de 2020 a 2021. Utilizou-se o método de cluster para agrupar as unidades federativas (UFs) com base na TMH. Em 2020, clusters com altas TMHs foram formados por UFs Norte/Nordeste. Em 2021, houve redução na TMH. Os clusters com maiores taxas permaneceram na região N/NE. Diferenças regionais foram observadas nas TMHs. Os achados podem refletir as desigualdades sociais e o acesso à atenção hospitalar, principalmente na faixa etária de menores de 1 ano pela gravidade da doença neste grupo.

Abstract The objective was to perform a spatial analysis of the hospital mortality rate (HMR) due to severe acute respiratory syndrome (SARS) attributed to COVID-19 among children and adolescents in Brazil from 2020 to 2021. A cluster method was used to group federal units (FUs) based on HMR. In 2020, clusters with high HMRs were formed by north/northeast FUs. In 2021, there was a reduction in HMR. Clusters with higher rates remained in the N/NE region. Regional differences were observed in the HMR. The findings may reflect social inequalities and access to hospital care, especially in the under 1-year-old age group due to the severity of the disease in this group.

Abstract The objective was to perform a spatial analysis of the hospital mortality rate (HMR) due to severe acute respiratory syndrome (SARS) attributed to COVID-19 among children and adolescents in Brazil from 2020 to 2021. A cluster method was used to group federal units (FUs) based on HMR. In 2020, clusters with high HMRs were formed by north/northeast FUs. In 2021, there was a reduction in HMR. Clusters with higher rates remained in the N/NE region. Regional differences were observed in the HMR. The findings may reflect social inequalities and access to hospital care, especially in the under 1-year-old age group due to the severity of the disease in this group.

Resumo Objetivou-se realizar uma análise espacial da taxa de mortalidade hospitalar (TMH) por síndrome respiratória aguda grave (SRAG) atribuída à COVID-19 em crianças e adolescentes no Brasil no período de 2020 a 2021. Utilizou-se o método de cluster para agrupar as unidades federativas (UFs) com base na TMH. Em 2020, clusters com altas TMHs foram formados por UFs Norte/Nordeste. Em 2021, houve redução na TMH. Os clusters com maiores taxas permaneceram na região N/NE. Diferenças regionais foram observadas nas TMHs. Os achados podem refletir as desigualdades sociais e o acesso à atenção hospitalar, principalmente na faixa etária de menores de 1 ano pela gravidade da doença neste grupo.

Resumen Objetivo Elaborar y analizar como prueba de validez de contenido una cartilla digital para la prevención de la violencia sexual en la adolescencia. Métodos Estudio metodológico llevado a cabo en tres etapas: elaboración de la cartilla digital a partir del modelo de Falkembach; validación del material por un comité de especialistas mediante el Índice de Concordancia (IC), considerado mayor a 80 %; y evaluación por parte del público destinatario (adolescentes) a partir de la aplicación del instrumento Suitability Assessment of Materials (SAM), considerado “Superior” entre 70 y 100 %, “Adecuado” de 40 a 69 %; “Inadecuado” de 0 a 39 %. Resultados La cartilla digital fue considerada válida por parte de los especialistas, con un índice de concordancia entre 86 y 100 %, y fue calificada como “Superior” por los adolescentes, con un porcentaje de la puntuación de 97 % en el instrumento SAM. Conclusión La cartilla fue considerada válida por los especialistas y por el público destinatario y es apta para utilizarla como recurso tecnológico para identificar situaciones de violencia sexual en la adolescencia y permitir la adopción de comportamientos preventivos. etapas Falkembach IC, IC , (IC) 8 adolescentes (adolescentes SAM, SAM (SAM) Superior “Superior 7 10 Adecuado “Adecuado 4 6 Inadecuado “Inadecuado 3 9 preventivos (IC (SAM 1

Abstract Objective To develop and analyze a digital booklet for preventing sexual violence in adolescence as proof of content validity. Methods This is a methodological study developed in three stages: digital booklet construction based on the Falkembach model; material validity by a committee of experts using the Index of Agreement (IA), considering it greater than 80%; and assessment by the target audience (adolescents), based on the application of the Suitability Assessment of Materials (SAM), considering it “Superior” between 70% and 100%; “Suitable”, between 40 and 69%; “Unsuitable”, between 0 and 39%. Results The digital booklet was considered valid by experts, with an agreement rate between 86% and 100%, and qualified as “Superior” by adolescents with a score percentage of 97% on the SAM. Conclusion The booklet was considered valid by experts and target audience, being able to be used as a technological resource to identify situations of sexual violence in adolescence and enable the adoption of preventive behaviors. stages model IA, IA , (IA) 80% 80 adolescents, (adolescents) SAM, SAM (SAM) Superior “Superior 70 100% 100 Suitable, Suitable “Suitable” 4 69% 69 Unsuitable, Unsuitable “Unsuitable” 39 39% 86 97 behaviors (IA 8 (adolescents (SAM 7 10 “Suitable 6 “Unsuitable 3 9 1

Resumo Objetivo Desenvolver e analisar como prova de validade de conteúdo cartilha digital para prevenção da violência sexual na adolescência. Métodos Estudo metodológico desenvolvido em três etapas: construção da cartilha digital a partir do modelo de Falkembach, validação do material por um comitê de especialistas por meio do Índice de Concordância (IC), considerando-o maior que 80%; e avaliação pelo público-alvo (adolescentes) a partir da aplicação do instrumento Suitability Assessment of Materials (SAM), considerando-o “Superior” entre 70% a 100%; “Adequado”, de 40 a 69%; “Inadequado”, de 0 a 39%. Resultados A cartilha digital foi considerada válida pelos especialistas, com o índice de concordância entre 86% e 100%; e qualificada como “Superior” pelos adolescentes com percentual de escore de 97% no instrumento SAM. Conclusão A cartilha foi considerada válida pelos especialistas e público-alvo, estando apta a ser utilizada como recurso tecnológico para identificar situações de violência sexual na adolescência e possibilitar a adoção de comportamentos preventivos. etapas Falkembach IC, IC , (IC) considerandoo considerando 80% 80 públicoalvo público alvo (adolescentes SAM, SAM (SAM) Superior “Superior 70 100% 100 Adequado, Adequado “Adequado” 4 69% 69 Inadequado, Inadequado “Inadequado” 39 39% 86 97 públicoalvo, alvo, preventivos (IC 8 (SAM 7 10 “Adequado 6 “Inadequado 3 9 1

Abstract Background: In pediatrics, cardiopulmonary arrest (CPA) is associated with high mortality and severe neurologic sequelae. Information on the causes and mechanisms of death below the age of 20 years could provide theoretical support for health improvement among children and adolescents. Objectives: To conduct a population analysis of mortality rates due to primary and multiple causes of death below the age of 20 years in both sexes from 1996 to 2019 in Brazil, and identify the frequency in which CPA was recorded in the death certificates (DCs) of these individuals and the locations where the deaths occurred, in order to promote strategies to improve the prevention of deaths. Method: Ecological time-series study of deaths below the age of 20 years from 1996 to 2019, evaluating the mortality rates (MRs) and proportional mortality (PM) by primary cause of death. We analyzed the percentages of CPA recorded in any line of the DC and the location where the deaths occurred. We calculated the MRs per 100,000 inhabitants and the PM by primary cause of death under the age of 20 years according to sex and age group, the percentages of death from primary causes by age group when CPA was described in any line of Parts I and II of the DC, and the percentage of deaths from primary causes according to their location of occurrence. We retrieved the data from DATASUS, IBGE, and SINASC. Results: From 1996 to 2019, there were 2,151,716 deaths below the age of 20 years in Brazil, yielding a mortality rate of 134.38 per 100,000 inhabitants. The death rate was highest among male neonates. Of all deaths, 249,334 (11.6%) had CPA recorded in any line of the DC. Specifically, CPA was recorded in 49,178 DCs between the ages of 1 and 4 years and in 88,116 of those between the ages of 29 and 365 days, corresponding, respectively, to 26% and 22% of the deaths in these age groups. These two age groups had the highest rates of CPA recorded in any line of the DC. The main primary causes of death when CPA was recorded in the sequence of death were respiratory, hematologic, and neoplastic diseases. Conclusion: Perinatal and external causes were the primary causes of death, with highest MRs under the age of 20 years in Brazil from 1996 to 2019. When multiple causes of death were considered, the main primary causes associated with CPA were respiratory, hematologic, and neoplastic diseases. Most deaths occurred in the hospital environment. Better understanding of the sequence of events in these deaths and improvements in teaching strategies in pediatric cardiopulmonary resuscitation are needed. Background pediatrics (CPA sequelae 2 adolescents Objectives 199 201 (DCs Method timeseries time series (MRs (PM 100000 100 000 100,00 occurrence DATASUS IBGE SINASC Results 2151716 151 716 2,151,71 13438 134 38 134.3 neonates 249334 249 334 249,33 11.6% 116 11 6 (11.6% Specifically 49178 49 178 49,17 88116 88 88,11 36 days corresponding respectively 26 22 respiratory hematologic diseases Conclusion considered environment needed 19 10000 10 00 100,0 215171 15 71 2,151,7 1343 13 3 134. 24933 24 33 249,3 11.6 (11.6 4917 17 49,1 8811 8 88,1 1000 0 100, 21517 7 2,151, 2493 249, 11. (11. 491 49, 881 88, 2151 2,151 (11 215 2,15 (1 21 2,1 ( 2,

Resumo Fundamento: Em pediatria, a parada cardiorrespiratória (PCR) está associada a alta mortalidade e graves sequelas neurológicas. Informações sobre as causas e mecanismos de morte abaixo de 20 anos poderiam fornecer subsídios teóricos para a melhoria da saúde de crianças e adolescentes. Objetivos: Realizar uma análise populacional das taxas de mortalidade por causas primárias e múltiplas de morte abaixo de 20 anos, em ambos os sexos, no período de 1996 a 2019, no Brasil, e identificar a frequência com que a PCR foi registrada nas declarações de óbito (DOs) desses indivíduos e os locais de ocorrência dos óbitos, a fim de promover estratégias para melhorar a prevenção de mortes. Método: Estudo ecológico de séries temporais de óbitos em indivíduos menores de 20 anos, no período de 1996 a 2019, avaliando as taxas de mortalidade (TMs) e a mortalidade proporcional (MP) por causa básica de morte. Foram analisados os percentuais de PCR registrados em qualquer linha da DO e o local de ocorrência dos óbitos. Foram calculadas as TMs por 100 mil habitantes e a MP por causa básica de morte nos menores de 20 anos segundo sexo e faixa etária, os percentuais de óbito por causas básicas por faixa etária quando a PCR foi descrita em qualquer linha das Partes I e II da DO, e o percentual de óbitos por causas básicas segundo o local de ocorrência. Os dados foram retirados do DATASUS, IBGE e SINASC. Resultados: De 1996 a 2019, ocorreram 2.151.716 óbitos de menores de 20 anos, no Brasil, gerando uma taxa de mortalidade de 134,38 por 100 mil habitantes. A taxa de óbito foi maior entre os recém-nascidos do sexo masculino. Do total de óbitos, 249.334 (11,6%) tiveram PCR registrada em qualquer linha da DO. Especificamente, a PCR foi registrada 49.178 vezes na DO na faixa etária entre 1 e 4 anos e em 88.116 vezes entre 29 e 365 dias, correspondendo, respectivamente, a 26% e 22% dos óbitos nessas faixas etárias. Essas duas faixas etárias apresentaram as maiores taxas de PCR registradas em qualquer linha da DO. As principais causas básicas de óbito quando a PCR foi registrada na sequência de óbitos foram doenças respiratórias, hematológicas e neoplásicas. Conclusão: As causas perinatais e externas foram as principais causas de morte, com maior TM nos menores de 20 anos no Brasil de 1996 a 2019. Quando consideradas as causas múltiplas de morte, as principais causas primárias associadas à PCR foram as doenças respiratórias, hematológicas e neoplásicas. A maioria dos óbitos ocorreu no ambiente hospitalar. Melhor compreensão da sequência de eventos nesses óbitos e melhorias nas estratégias de ensino em ressuscitação cardiopulmonar pediátrica são necessárias. Fundamento pediatria (PCR neurológicas 2 adolescentes Objetivos sexos 199 2019 DOs (DOs mortes Método (TMs (MP 10 DATASUS SINASC Resultados 2151716 151 716 2.151.71 13438 134 38 134,3 recémnascidos recém nascidos masculino 249334 249 334 249.33 11,6% 116 11 6 (11,6% Especificamente 49178 49 178 49.17 88116 88 88.11 36 dias correspondendo respectivamente 26 22 respiratórias neoplásicas Conclusão hospitalar necessárias 19 201 215171 15 71 2.151.7 1343 13 3 134, 24933 24 33 249.3 11,6 (11,6 4917 17 49.1 8811 8 88.1 21517 7 2.151. 2493 249. 11, (11, 491 49. 881 88. 2151 2.151 (11 215 2.15 (1 21 2.1 ( 2.

Abstract In formative pathways with future French language teachers, the erasure of criticality in the planning of didactic sequences involving the search, selection, analysis, adaptation, organization, and sharing of digital materials has been observed ( Deschaine; Sharma, 2015 ). This issue will be discussed in this article, which aims to elucidate the limits and possibilities in the processes of curation and creation of technical-pedagogical resources for language education. The results of the analyses conducted so far indicate that the sources to which those students constantly resort in preparing their lesson plans (videos and podcasts instantiated on media portals and streaming platforms) can hinder the ethical, aesthetic ( Rocha, 2019 ), and decolonial ( Veronelli; Daitch, 2021 ) didactic design of teaching-learning experiences for the expansion of language repertoires. In order to understand the described problem, in addition to discussing the partial results of two ongoing research projects, we intend to highlight the need to create theoretical-methodological frameworks that can decolonize the curation-authorship of materials in this field, from the training of educators to their work in learning communities. teachers search selection analysis adaptation organization Deschaine Sharma 201 . article technicalpedagogical technical pedagogical education videos platforms ethical Rocha , Veronelli Daitch 202 teachinglearning teaching repertoires problem projects theoreticalmethodological theoretical methodological curationauthorship authorship field communities 20 2

Resumo Em percursos formativos com futuros/as professores/as de língua francesa, foi observado o apagamento da criticidade em planejamentos de sequências didáticas que envolvem a busca, seleção, análise, adaptação, organização e compartilhamento de materiais digitais ( Deschaine; Sharma, 2015 ). Tal problemática será discutida neste artigo, que visa explicitar limites e possibilidades nos processos de curadoria e criação de recursos técnico-pedagógicos para a educação linguística. Os resultados das análises até o momento realizadas apontam que as fontes às quais permanentemente recorrem aqueles estudantes na preparação de seus planos de aula (vídeos e podcasts instanciados em portais midiáticos e em plataformas de streaming ) podem inviabilizar o desenho didático ético, estético ( Rocha, 2019 ) e decolonial ( Veronelli; Daitch, 2021 ) de experiências de ensino-aprendizagem para a expansão de repertórios em línguas. Com o intuito de compreender o problema descrito, pretende-se, para além da discussão dos resultados parciais de duas pesquisas em andamento, apontar a necessidade de criarmos referenciais teórico-metodológicos que possam decolonizar a curadoria-autoria de materiais nesse campo, desde a formação de educadores/as à sua atuação em comunidades de aprendizagem. futurosas futuros professoresas professores francesa busca seleção análise adaptação Deschaine Sharma 201 . artigo técnicopedagógicos técnico pedagógicos linguística vídeos ético Rocha Veronelli Daitch 202 ensinoaprendizagem ensino aprendizagem línguas descrito pretendese, pretendese pretende se, se pretende-se andamento teóricometodológicos teórico metodológicos curadoriaautoria autoria campo educadoresas educadores 20 2

Abstract Introduction: Much is discussed about the training of health professionals prepared to meet the real needs of the population in the context of the Health Care System as recommended by the National Curriculum Guidelines, aiming at comprehensive care. Primary Care stands out as an important practice scenario in this context, including the internship, considering the autonomy of this phase. Objective: To analyze the perceptions of graduates of a medical course in relation to the pediatric internship in Primary Care. Method: Descriptive, exploratory research with a qualitative approach, developed through online interviews with medical graduates, graduated from a public higher education institution in the interior of São Paulo in 2018 and 2019. The data was analyzed using content analysis. Results and discussion: Eleven 2018 graduates and 15 2019 graduates were interviewed, with different professional activities since the end of the course. The category explored in this article will be “Learning opportunity during Primary Care in Pediatrics.” Experiencing Primary Care in Pediatrics provided different learning opportunities regarding the comprehensive care of the child, understanding the importance of its context and repercussions. Final Considerations: Knowing about the Health Care Network since the beginning of the course allowed students to understand the difficulties experienced in this network and the impact on care. The most prevalent and low-complexity situations are the reality of graduates in professional practice and need to be addressed during the teaching-learning process of the internship, favoring their performance. Introduction Guidelines phase Objective Method Descriptive approach 201 analysis discussion 1 interviewed Learning Pediatrics. child repercussions Considerations lowcomplexity low complexity teachinglearning teaching performance 20 2

Resumo Introdução: Muito se discute sobre a formação de profissionais de saúde preparados para atender às reais necessidades da população no contexto do Sistema Único de Saúde como preconizado pelas Diretrizes Curriculares Nacionais, almejando o cuidado integral. A Atenção Básica se destaca como importante cenário de prática nesse contexto, inclusive no internato, considerando a autonomia e o domínio dessa fase. Objetivo: Este estudo teve como objetivo analisar as percepções dos egressos de um curso médico em relação ao internato em pediatria na Atenção Básica. Método: Trata-se de pesquisa descritiva, exploratória com abordagem qualitativa, desenvolvida por meio de entrevistas on-line com egressos de Medicina, formados em uma instituição de ensino superior pública do interior paulista nos anos de 2018 e 2019. Os dados foram examinados por meio da análise de conteúdo temática. Resultado: Entrevistaram-se 11 egressos de 2018 e 15 egressos de 2019, com atuações profissionais diversas desde a finalização do curso. A categoria explorada neste artigo será “Oportunidade de aprendizagem durante a Atenção Básica em pediatria”. Vivenciar a Atenção Básica em pediatria oportunizou aprendizados diversos quanto ao cuidado integral da criança, compreendendo a importância de seu contexto e e de suas repercussões. Conclusão: Conhecer sobre a Rede de Atenção à Saúde desde o início do curso possibilitou entender as dificuldades vivenciadas nela e o impacto no cuidado. As situações mais prevalentes e de baixa complexidade são a realidade do egresso na atuação profissional e precisam ser abordadas durante o processo de ensino-aprendizagem do internato, favorecendo a atuação dele. Introdução Nacionais fase Objetivo Método Tratase Trata descritiva qualitativa online on line Medicina 201 2019 temática Resultado Entrevistaramse Entrevistaram 1 Oportunidade pediatria. . pediatria” criança repercussões Conclusão ensinoaprendizagem dele 20 2

Abstract Background: People with haemophilia (PwH) are living longer. Therefore, they can develop atherosclerotic cardiovascular disease (ASCVD). Electrocardiogram (ECG) alterations may be a sign of initial ASCVD before the occurrence of symptoms. Objective: To describe the prevalence of resting ECG alterations among PwH adults asymptomatic for ASCVD. Methods: PwH aged ≥ 30 years without previous ASCVD events were considered for the analysis. Resting ECG traces were analysed according to international reference values and the Brazilian Longitudinal Adult Health Study (ELSA-Brasil) results for asymptomatic Brazilian men. Based on the established normal values and using the QT index, we further described the altered ECGs as minor or major changes, according to the Minnesota Code. Differences between prevalences were evaluated by Pearson's χ2 test. Differences between medians were evaluated by the Mann-Whitney U test. A p-value < 0.05 was accepted as statistically significant. Results: A total of 64 PwH were included in the study. Median age was 44 years (interquartile range 35-52). Most patients had haemophilia A (81%) and 47% were severe. The prevalence of obesity, systemic arterial hypertension (SAH), diabetes mellitus (DM), and dyslipidaemia were 16%, 56%, 14%, and 72%, respectively. All the PwH had sinus rhythm, except for one, who had an implanted pacemaker due to idiopathic third-degree atrioventricular block. Altered ECGs were found in 25% and 30% of PwH, according to established criteria and ELSA-Brasil criteria, respectively. Major changes were found in eight (13%) PwH according to the Minnesota Code, including two ECGs with ischaemia-like wall inactivity. Conclusions: The prevalence of altered ECG varied from 25% to 30% among asymptomatic PwH. Background (PwH longer Therefore . (ASCVD) (ECG symptoms Objective Methods 3 analysis ELSABrasil ELSA Brasil (ELSA-Brasil men index Code Pearsons Pearson s χ test MannWhitney Mann Whitney pvalue p value 005 0 05 0.0 significant Results 6 study 4 interquartile 3552. 3552 35 52 35-52) 81% 81 (81% 47 severe obesity SAH, SAH , (SAH) DM, DM (DM) 16 16% 56 56% 14 14% 72 72% respectively rhythm one thirddegree third degree block 25 13% 13 (13% ischaemialike ischaemia like inactivity Conclusions (ASCVD 00 0. 355 5 35-52 8 (81 (SAH (DM 1 7 2 (13 35-5 (8 (1 35- (

Abstract The objective was to perform a spatial analysis of the hospital mortality rate (HMR) due to severe acute respiratory syndrome (SARS) attributed to COVID-19 among children and adolescents in Brazil from 2020 to 2021. A cluster method was used to group federal units (FUs) based on HMR. In 2020, clusters with high HMRs were formed by north/northeast FUs. In 2021, there was a reduction in HMR. Clusters with higher rates remained in the N/NE region. Regional differences were observed in the HMR. The findings may reflect social inequalities and access to hospital care, especially in the under 1-year-old age group due to the severity of the disease in this group. HMR (HMR SARS (SARS COVID19 COVID 19 COVID-1 202 2021 FUs (FUs northnortheast north northeast NNE N NE region care 1yearold yearold 1 year old COVID1 COVID- 20 2

Resumo Objetivou-se realizar uma análise espacial da taxa de mortalidade hospitalar (TMH) por síndrome respiratória aguda grave (SRAG) atribuída à COVID-19 em crianças e adolescentes no Brasil no período de 2020 a 2021. Utilizou-se o método de cluster para agrupar as unidades federativas (UFs) com base na TMH. Em 2020, clusters com altas TMHs foram formados por UFs Norte/Nordeste. Em 2021, houve redução na TMH. Os clusters com maiores taxas permaneceram na região N/NE. Diferenças regionais foram observadas nas TMHs. Os achados podem refletir as desigualdades sociais e o acesso à atenção hospitalar, principalmente na faixa etária de menores de 1 ano pela gravidade da doença neste grupo. Objetivouse Objetivou se TMH (TMH SRAG (SRAG COVID19 COVID 19 COVID-1 202 2021 Utilizouse Utilizou (UFs NorteNordeste Norte Nordeste Norte/Nordeste NNE N NE N/NE grupo COVID1 COVID- 20 2

Abstract In low and middle-income countries such as Brazil, most maternal deaths are related to hypertensive complications. Preeclampsia is the leading cause of maternal mortality and morbidity. Significant proportion is associated with the following factors: lack of identification of high-risk women, lack of adequate prevention, difficulty in maintaining a high-risk prenatal follow-up, delayed diagnosis, insecurity and low use of magnesium sulphate, delayed pregnancy interruption and lack of postpartum follow-up of these high-risk cases. Four major actions are proposed to minimize this alarming clinical picture and reduce the mortality rates due to preeclampsia, called the "4 P Rule" (Adequate Prevention – Vigilant Prenatal Care – Timely Delivery (Parturition) – Safe Postpartum). From this simple "rule" we can open a range of important processes and reminders that may help in the guidance of preeclampsia management. middleincome middle income Brazil complications morbidity factors highrisk high risk women prevention followup, followup follow up, up diagnosis sulphate cases 4 " Rule Adequate Parturition (Parturition Postpartum. Postpartum . Postpartum) rule "rule management

ABSTRACT Women living with human immunodeficiency virus are at an increased risk of developing cancers related to human papillomavirus (HPV). Thus, it is important to combine clinical assessments, serological screening, and HPV data for planning prevention policies. This study aimed to identify HPV and its specific types in the cervical, anal, and oral mucosa of HIV-seropositive women, associating it with viral load and lymphocyte count. Sociodemographic characteristics, health data (CD4+ and CD8+ T cell counts and viral load), and biological samples (cervical, anal, and oral) were collected from 86 HIV-positive women undergoing antiretroviral therapy. Data were classified according to the presence or absence of HPV-DNA, HPV-DNA presence at one or more anatomic sites, and level of oncogenic risk, considering low- and high-risk oncogenic HPV-DNA groups. The presence of HPV in the cervicovaginal site was 65.9%, 63.8% in anal canal, and 4.2% in oral mucosa. A viral load ≥75 HIV copies/mL was associated with the presence of HPV-DNA. There was an association between viral load and the low-risk HPV or high-risk HPV groups. We found a high prevalence of HPV infection in HIV-seropositive women, particularly in the cervical and anal mucosa, with viral load ≥75 HIV copies/mL being associated with HPV-DNA presence. HPV. . (HPV) Thus assessments screening policies HIVseropositive seropositive count characteristics CD4+ CD4 CD (CD4 CD8 load, , load) (cervical 8 HIVpositive positive therapy HPVDNA, HPVDNA DNA, DNA sites low highrisk groups 659 65 9 65.9% 638 63 63.8 canal 42 4 2 4.2 75 ≥7 copiesmL copies mL HPVDNA. DNA. lowrisk (HPV (CD 6 65.9 63. 4. 7 ≥ 65.

Abstract: This study examines and assesses the chemistry of sanitizing alcohol for elementary school students during the COVID-19 pandemic via distance learning. In addition, it addresses how to apply ethnic-racial education in a racial literacy program by examining the roles played by the media, science, and the pandemic. We conducted a pedagogical intervention with public school students from the periphery of a Brazilian city, integrating Afrocentric research components and analyzing the data using the polyrational tool of chemical knowledge and the hermeneutics of depth. The study demonstrates the feasibility of discussing the concept of alcohol function, despite the challenges posed by the circular movement of chemical knowledge dimensions. The article also looks at the experiences of the Afro-Brazilian community and the relationship between scientific information and the media during the pandemic. Abstract COVID19 COVID 19 COVID-1 learning addition ethnicracial ethnic science city depth function dimensions AfroBrazilian Afro COVID1 1 COVID-

Resumo: Neste artigo buscou-se discutir e analisar o ensino remoto de química de saneantes em tempos de Covid-19 e os discursos sobre os elementos da mídia, ciência e pandemia, com a implementação da educação para as relações étnico-raciais com estudantes da educação básica, no projeto de letramento racial, o projeto Afrocientista. Com aspectos de uma pesquisa afrocêntrica, a intervenção pedagógica desenvolvida ocorreu com estudantes da escola pública e de periferia da Grande Goiânia, no estado de Goiás. Os dados foram analisados a partir da hermenêutica da profundidade do dispositivo polirracional do conhecimento químico. Os resultados apontam que, mesmo frente às limitações do ensino remoto, foi possível discutir sobre o conceito de função alcóolica, ainda que com a dificuldade do movimento circular das dimensões do conhecimento químico, como também as interfaces dos meios de comunicação e do conhecimento científico diante da pandemia da Covid-19 e as vivências da população afro-brasileira. Resumo buscouse buscou se Covid19 Covid 19 Covid-1 mídia étnicoraciais étnico raciais básica racial Afrocientista afrocêntrica Goiânia Goiás químico alcóolica afrobrasileira. afrobrasileira afro brasileira. brasileira afro-brasileira Covid1 1 Covid-

Abstract This cross-sectional study evaluated the association between salivary immunoglobulins, plaque index, and gingival index in Brazilian children with and without type 1 diabetes mellitus (DM1). The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist for the reporting of observational studies was followed. The DM1 group had 38 children, and an equal number of volunteers matched by sex and age were recruited as controls. Clinical examination was performed for plaque index and gingival index determination. Non-stimulated whole saliva was collected. Concentrations of IgA, IgG, and IgM were determined by ELISA test. Data were tested by the Kolmogorov-Smirnov, Mann-Whitney, and Spearman tests and a multiple linear regression model (p<0.05) was performed. Gingival index was higher in the Control (DM1: 0.16±0.17; Control: 0.24±0.23, p=0.040). In DM1, there was a correlation between IgA and age (rho=0.371, p=0.024), IgM and IgG (rho=0.459, p=0.007), and IgM and gingival index (rho=0.394, p=0.014). In DM1, multiple linear regression showed that age (p=0.041; β=0.363), gingival index (p=0.041; β=0.398), and plaque index (p=0.008; β=-0.506) were good predictors of IgA levels in saliva. Thus, IgA was the only researched immunoglobulin that was directly associated with plaque and gingival indices in Brazilian children with DM1, but not in control subjects. crosssectional cross sectional immunoglobulins DM1. DM . (DM1) STROBE (STROBE followed 3 controls determination Nonstimulated Non stimulated collected test KolmogorovSmirnov, KolmogorovSmirnov Kolmogorov Smirnov, Smirnov Kolmogorov-Smirnov MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney p<0.05 p005 p 0 05 (p<0.05 (DM1 0.16±0.17 016017 16 17 024023 24 23 0.24±0.23 p=0.040. p0040 p=0.040 040 p=0.040) rho=0.371, rho0371 rho 371 (rho=0.371 p=0.024, p0024 p=0.024 , 024 p=0.024) rho=0.459, rho0459 459 (rho=0.459 p=0.007, p0007 p=0.007 007 p=0.007) rho=0.394, rho0394 394 (rho=0.394 p=0.014. p0014 p=0.014 014 p=0.014) p=0.041 p0041 041 (p=0.041 β=0.363, β0363 β β=0.363 363 β=0.363) β=0.398, β0398 β=0.398 398 β=0.398) p=0.008 p0008 008 (p=0.008 β=0.506 β0506 β= 0.506 506 β=-0.506 Thus subjects p<0.0 p00 (p<0.0 (DM 0.16±0.1 01601 02402 2 0.24±0.2 p004 p=0.04 04 rho=0.371 rho037 37 (rho=0.37 p002 p=0.02 02 rho=0.459 rho045 45 (rho=0.45 p000 p=0.00 00 rho=0.394 rho039 39 (rho=0.39 p001 p=0.01 01 (p=0.04 β036 β=0.36 36 β039 β=0.39 (p=0.00 β=0.50 β050 0506 0.50 50 β=-0.50 p<0. p0 (p<0. 0.16±0. 0160 0240 0.24±0. p=0.0 rho=0.37 rho03 (rho=0.3 rho=0.45 rho04 4 (rho=0.4 rho=0.39 (p=0.0 β03 β=0.3 β=0.5 β05 050 0.5 5 β=-0.5 p<0 (p<0 0.16±0 016 0.24±0 p=0. rho=0.3 rho0 (rho=0. rho=0.4 (p=0. β0 β=0. 0. β=-0. p< (p< 0.16± 0.24± p=0 rho=0. (rho=0 (p=0 β=0 β=-0 (p 0.16 0.24 p= rho=0 (rho= (p= β=- 0.1 0.2 rho= (rho

The discussions on human rights, gender and race are global and urgent. Using elements of participatory research, this study aimed to analyze, understand and characterize the formative process of postgraduate student’s knowledge and reflections mobilized on the gender and sexuality in the teaching of Science/Chemistry. The results show that the students started from a counter-hegemonic intentionality regarding the way in which the issue of hormones is traditionally treated in Science/Chemistry teaching. Furthermore, they recognized scientific knowledge as active in the production and reproduction of systems of oppression teacher on diversity education transgressive way of teaching the subject, beyond the binary conception of gender. The results revealed the possibility of rationalizing sexual and gender dissidences as a form of innovation, as well as the importance of formative processes to rethink dominant epistemologies for the advancement of educational and practices in and for education, to break with the cisheteromonormative perspective that erases the production and existence of people who flee from this logic in Science/Chemistry. rights urgent research analyze student s ScienceChemistry Science Chemistry counterhegemonic counter hegemonic Furthermore subject innovation

Resumo Introdução: Embora a utilização de Marcadores de Consumo Alimentar esteja prevista na atenção primária à saúde, seu uso pelas equipes de saúde bucal ainda é incipiente. Objetivo: Analisar a associação do consumo de alimentos cariogênicos, avaliado através de marcadores do consumo alimentar, com a ocorrência de cárie dentária não tratada em pré-escolares. Método: Envolveu 432 crianças (18-36 meses) em uma amostra representativa dos Centros Municipais de Educação Infantil (São José dos Pinhais-PR). Os pais/responsáveis responderam um questionário socioeconômico e demográfico, e as crianças foram avaliadas por examinadora calibrada (Kappa=0,80). O consumo de alimentos cariogênicos foi mensurado através do instrumento Marcadores de Consumo Alimentar (Ministério da Saúde; Brasil). O escore de consumo de alimentos cariogênicos (EAC) foi obtido pela soma de relatos de consumo de alimentos com açúcar livre. Resultados: A prevalência de cárie dentária não tratada foi 21% (IC95% 17–24). Na regressão múltipla de Poisson com variância robusta, a maior prevalência de cárie dentária não tratada foi associada ao maior EAC (RPa=1,16; IC95% 1,01–1,34; p=0,035), a maior idade das crianças (RPa=1,05; IC95% 1.01–1.10; p=0,021) e inversamente a maior escolaridade dos responsáveis (RPa=0,62; IC95% 0,42–0,92; p=0,017). Conclusão: O consumo de alimentos cariogênicos, medido através do Marcadores de Consumo Alimentar, foi associado com uma maior prevalência de cárie dentária não tratada em pré-escolares. Introdução incipiente Objetivo alimentar préescolares. préescolares pré escolares. escolares pré-escolares Método 43 1836 18 36 (18-3 meses São PinhaisPR. PinhaisPR Pinhais PR . Pinhais-PR) paisresponsáveis pais demográfico Kappa=0,80. Kappa080 Kappa Kappa=0,80 0 80 (Kappa=0,80) Ministério Saúde Brasil. Brasil Brasil) (EAC livre Resultados 21 IC95 IC (IC95 17–24. 1724 17–24 17 24 17–24) robusta RPa=1,16 RPa116 RPa 1 16 (RPa=1,16 1,01–1,34 101134 01 34 p=0,035, p0035 p p=0,035 , 035 p=0,035) RPa=1,05 RPa105 05 (RPa=1,05 1.01–1.10 101110 10 p=0,021 p0021 021 RPa=0,62 RPa062 62 (RPa=0,62 0,42–0,92 042092 42 92 p=0,017. p0017 p=0,017 017 p=0,017) Conclusão 4 183 3 (18- Pinhais-PR Kappa08 Kappa=0,8 8 (Kappa=0,80 2 IC9 (IC9 172 17–2 RPa=1,1 RPa11 (RPa=1,1 1,01–1,3 10113 p003 p=0,03 03 RPa=1,0 RPa10 (RPa=1,0 1.01–1.1 10111 p=0,02 p002 02 RPa=0,6 RPa06 6 (RPa=0,6 0,42–0,9 04209 9 p001 p=0,01 (18 Kappa0 Kappa=0, (Kappa=0,8 (IC 17– RPa=1, RPa1 (RPa=1, 1,01–1, 1011 p00 p=0,0 1.01–1. RPa=0, RPa0 (RPa=0, 0,42–0, 0420 (1 Kappa=0 (Kappa=0, RPa=1 (RPa=1 1,01–1 101 p0 p=0, 1.01–1 RPa=0 (RPa=0 0,42–0 042 ( Kappa= (Kappa=0 RPa= (RPa= 1,01– p=0 1.01– 0,42– 04 (Kappa= (RPa 1,01 p= 1.01 0,42 (Kappa 1,0 1.0 0,4 1, 1. 0,

Abstract Background: Although the use of Food Consumption Markers is foreseen in primary health care, their use by oral health teams is still incipient. Objective: The objective of this study was to investigate the association of cariogenic food consumption, measured through the food consumption markers, with the occurrence of untreated dental caries in preschoolers. Method: The study included 432 children (aged 18–36 months) in a representative sample of the Municipal Centers for Early Childhood Education (São José dos Pinhais, Pr). The parents/guardians answered a socioeconomic and demographic questionnaire, and the children were examined by a calibrated examiner (kappa=0.80). Cariogenic food consumption was measured using the Food Consumption Markers instrument (Ministry of Health, Brazil). The score of consumption of cariogenic foods was obtained by the sum of reports of consumption of foods with free sugar (SCF). Results: The prevalence of untreated dental caries was 21% (95%CI 17–24). In the multiple Poisson regression with robust variance, the higher prevalence of untreated dental caries was associated with the higher SCF (RPa=1.16; 95%CI 1.01–1.34; p=0.035), with the older age of the children (PRa=1.05; 95%CI 1.01–1.10; p=0.021), and inversely to the higher guardians’ education (PRa=0.62; 95%CI: 0.42–0.92; p=0.017). Conclusion: Cariogenic food consumption, measured through the Food Consumption Markers instrument, was associated with a higher prevalence of untreated dental caries in preschoolers. Background care incipient Objective markers preschoolers Method 43 aged 1836 18 36 18–3 months São Pinhais Pr. Pr . Pr) parentsguardians parents guardians questionnaire kappa=0.80. kappa080 kappa kappa=0.80 0 80 (kappa=0.80) Ministry Health Brazil. Brazil Brazil) SCF. (SCF) Results 21 95CI CI 95 17–24. 1724 17–24 17 24 17–24) variance RPa=1.16 RPa116 RPa 1 16 (RPa=1.16 1.01–1.34 101134 01 34 p=0.035, p0035 p p=0.035 , 035 p=0.035) PRa=1.05 PRa105 PRa 05 (PRa=1.05 1.01–1.10 101110 10 p=0.021, p0021 p=0.021 021 p=0.021) PRa=0.62 PRa062 62 (PRa=0.62 0.42–0.92 042092 42 92 p=0.017. p0017 p=0.017 017 p=0.017) Conclusion 4 183 3 18– kappa08 kappa=0.8 8 (kappa=0.80 (SCF 2 9 172 17–2 RPa=1.1 RPa11 (RPa=1.1 1.01–1.3 10113 p003 p=0.03 03 PRa=1.0 PRa10 (PRa=1.0 1.01–1.1 10111 p002 p=0.02 02 PRa=0.6 PRa06 6 (PRa=0.6 0.42–0.9 04209 p001 p=0.01 kappa0 kappa=0. (kappa=0.8 17– RPa=1. RPa1 (RPa=1. 1.01–1. 1011 p00 p=0.0 PRa=1. PRa1 (PRa=1. PRa=0. PRa0 (PRa=0. 0.42–0. 0420 kappa=0 (kappa=0. RPa=1 (RPa=1 1.01–1 101 p0 p=0. PRa=1 (PRa=1 PRa=0 (PRa=0 0.42–0 042 kappa= (kappa=0 RPa= (RPa= 1.01– p=0 PRa= (PRa= 0.42– 04 (kappa= (RPa 1.01 p= (PRa 0.42 (kappa 1.0 0.4 1. 0.

SUMMARY OBJECTIVE: The aim of this study was to evaluate the prevalence and risk factors related to metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease patients. METHODS: This is a cross-sectional study conducted on adults with inflammatory bowel disease from 2019 to 2021. Metabolic dysfunction-associated steatotic liver disease encompasses patients with steatosis and at least one cardiometabolic risk factor. Patients with alcohol consumption ≥20 g/day, chronic liver diseases, or methotrexate use were excluded. RESULTS: Almost 140 patients were included: 67.1% were female, with a mean age of 49.7±13.7 years, and 63.6% had Crohn's disease. The mean duration of inflammatory bowel disease was 9.7±7.9 years. Metabolic dysfunction-associated steatotic liver disease was observed in 44.3% and advanced liver fibrosis was excluded in 63.5% by Fibrosis-4. Patients with metabolic dysfunction-associated steatotic liver disease were older (p = 0.003) and had a higher number of metabolic syndrome components (2.9±1.1 versus 1.6±1.0; p<0.001), greater abdominal circumference (p<0.001), and body mass index (p<0.001). The only factor related to inflammatory bowel disease associated with metabolic dysfunction-associated steatotic liver disease was disease duration (11.6±9.5 versus 8.3±6.2; p = 0.017). A higher number of metabolic syndrome components and obesity increase by 2.2 times and an altered waist circumference by 2.6 times the occurrence of metabolic dysfunction-associated steatotic liver disease. CONCLUSION: A high prevalence of metabolic dysfunction-associated steatotic liver disease was observed in patients with inflammatory bowel disease, with the main risk factors being associated with metabolic syndrome predicting it, but not with inflammatory bowel disease features and/or its treatment. OBJECTIVE dysfunctionassociated dysfunction METHODS crosssectional cross sectional 201 2021 20 ≥2 gday g day g/day diseases RESULTS 14 included 671 67 1 67.1 female 497137 49 7 13 49.7±13. years 636 63 6 63.6 Crohns Crohn s 9779 9 9.7±7. 443 44 3 44.3 635 5 63.5 Fibrosis4. Fibrosis4 Fibrosis 4. 4 Fibrosis-4 0.003 0003 0 003 2.9±1.1 2911 2 (2.9±1. 1.6±1.0 1610 p<0.001, p0001 p<0.001 , 001 p<0.001) (p<0.001) p<0.001. . 11.6±9.5 11695 11 (11.6±9. 8.3±6.2 8362 8 0.017. 0017 0.017 017 0.017) 22 2. 26 CONCLUSION it andor treatment 202 ≥ 67. 49713 49.7±13 63. 977 9.7±7 44. Fibrosis- 0.00 000 00 2.9±1. 291 (2.9±1 1.6±1. 161 p000 p<0.00 (p<0.001 11.6±9. 1169 (11.6±9 8.3±6. 836 0.01 01 4971 49.7±1 97 9.7± 0.0 2.9±1 29 (2.9± 1.6±1 16 p00 p<0.0 (p<0.00 11.6±9 116 (11.6± 8.3±6 83 497 49.7± 9.7 0. 2.9± (2.9 1.6± p0 p<0. (p<0.0 11.6± (11.6 8.3± 49.7 9. 2.9 (2. 1.6 p<0 (p<0. 11.6 (11. 8.3 49. (2 1. p< (p<0 11. (11 8. ( (p< (1