ABSTRACT Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk development. However, the mechanisms of reduced kidney function with CVD risk are unclear. This study aimed to investigate the association between kidney function and Framingham risk score (FRS) in participants with traditional cardiovascular risk factors and normal estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m² in an admixed population of Brazil. The participants were divided into three groups according to FRS: low risk group with 0% to <10%, moderate risk group with ≥10% to 20% and high risk group with >20%. The eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Data from participants were collected by questionnaire, and blood and urine samples were collected to analyze biochemical markers. A total of 214 subjects aged 53±10 years old was collected. There were 77 individuals in low risk group, 59 in moderate risk group and 78 in high-risk group. Mean eGFRCKD-EPI was 89.39±15.05 mL/min/1.73 m² and 90.74±16.17 mL/min/1.73 m2 when race adjustment. The results indicated that there is an increasing the cardiovascular risk with a decreased of eGFR, conforming to a significant inverse correlation observed between eGFR and FRS with Spearman correlation (R²=-0.256, p<0.001; R²=-0.224, p=0.001, when adjusted for race). There was a statistically significant difference in eGFRCKD-EPI (p<0.001) and eGFRCKD-EPI with race adjustment (p=0.002) among risk groups. The data suggests that the reduction eGFR is associated with elevated FRS among Brazilian adults without CKD. Furthermore, the results suggest that race adjustment it’s not necessary in Brazilian population.

RESUMO O objetivo do estudo foi investigar a associação entre estresse oxidativo e dano ao DNA com o tempo de enxertia em pacientes submetidos ao transplante de células-tronco hematopoéticas autólogo (TCTH). Participaram do estudo 37 pacientes submetidos ao TCTH autólogo com diagnóstico de mieloma múltiplo (MM) e Linfomas (Hodgkin e não Hodgkin). Biomarcadores de estresse oxidativo e índice de dano ao DNA (ID) foram determinados no estado basal (Pré-RC) das doenças e durante o regime de condicionamento (RC), um dia após o TCTH, dez dias após o TCTH e vinte dias após o TCTH e no grupo controle composto por 30 individuos saudáveis. Os resultados demonstraram que os dois grupos de pacientes apresentaram um estado hiperoxidativo com elevado ID quando comparados ao estado basal e ao grupo controle e que o RC exacerbou essa condição. No entanto, após o tempo de acompanhamento do estudo, esse quadro foi reestabelecido ao estado basal de cada patologia. Os pacientes do estudo com MM apresentaram uma média do tempo de enxertia de 10,75 dias (8 a 13 dias), e de 10,15 dias (8 a 15 dias) para o grupo Linfoma. Nos pacientes com MM houve uma correlação negativa entre o tempo de enxertia e os níveis basais de GPx (r=-0,54; p=0,034), indicando que níveis mais baixos de GPx estão relacionados a um maior tempo de enxertia, e para o ID, a correlação foi positiva (r=0,529; p=0,030). No grupo com Linfoma, observou-se que os níveis basais de NOx correlacionaram-se positivamente com o tempo de enxertia (r= 0,4664; p=0,032). Os dados apontam para o potencial desses biomarcadores como preditores da toxicidade e do tempo de enxertia em pacientes com MM e Linfomas submetidos ao TCTH autólogo

ABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage index (DI) were performed at baseline (pre-CR) of the disease and during the conditioning regimen (CR), one day after the HSCT, ten days after HSCT and twenty days after HSCT, as well as in the control group consisting of 30 healthy individuals. The outcomes showed that both groups of patients had an hyperoxidative state with high DI when compared to baseline and to the control group and that the CR exacerbated this condition. However, after the follow-up period of the study, this picture was re-established to the baseline levels of each pathology. The study patients with MM showed a mean grafting time of 10.75 days (8 to 13 days), with 10.15 days (8 to 15 days) for the lymphoma patients. In patients with MM, there was a negative correlation between the grafting time and the basal levels of GPx (r = -0.54; p = 0.034), indicating that lower levels of this important enzyme are associated with a longer grafting time. For the DI, the correlation was a positive one (r = 0.529; p = 0.030). In the group with lymphoma, it was observed that the basal levels of NOx were positively correlated with grafting time (r = 0.4664, p = 0.032). The data indicate the potential of these biomarkers as predictors of toxicity and grafting time in patients with MM and Lymphomas submitted to autologous HSCT.

Estudo descritivo de abordagem quanti-qualitativa, cujo objetivo foi avaliar a aplicação do Assessment of Chronic Illness Care (ACIC) e seus resultados junto aos profissionais de equipes da Estratégia Saúde da Família, em Campo Grande (MS). A amostra constituiu-se de 30 profissionais em 5 equipes, e a coleta de dados foi realizada em maio e junho de 2014, por meio do instrumento ACIC. A média das equipes resultou em capacidade razoável para atenção às condições crônicas, sendo o sistema de informação clínica a principal fragilidade e o desenho do sistema de prestação de serviços de saúde, o maior potencial.

Descriptive study of quantitative and qualitative approach, sought to evaluate the application of the Assessment of Chronic Illness Care (ACIC) and its results along with professionals of teams of the Family Health Strategy, in Campo Grande (MS). The sample consisted of 30 professionals in 5 teams, and data collection was carried out in May and June of 2014, through the application of ACIC instrument. The average of the teams resulted in reasonable ability to the care for chronic conditions, and the clinical information system as the main weakness and the drawing of the healthcare service delivery system, the greatest potential.

Estudo descritivo de abordagem quanti-qualitativa, cujo objetivo foi avaliar a aplicação do Assessment of Chronic Illness Care (ACIC) e seus resultados junto aos profissionais de equipes da Estratégia Saúde da Família, em Campo Grande (MS). A amostra constituiu-se de 30 profissionais em 5 equipes, e a coleta de dados foi realizada em maio e junho de 2014, por meio do instrumento ACIC. A média das equipes resultou em capacidade razoável para atenção às condições crônicas, sendo o sistema de informação clínica a principal fragilidade e o desenho do sistema de prestação de serviços de saúde, o maior potencial.

Descriptive study of quantitative and qualitative approach, sought to evaluate the application of the Assessment of Chronic Illness Care (ACIC) and its results along with professionals of teams of the Family Health Strategy, in Campo Grande (MS). The sample consisted of 30 professionals in 5 teams, and data collection was carried out in May and June of 2014, through the application of ACIC instrument. The average of the teams resulted in reasonable ability to the care for chronic conditions, and the clinical information system as the main weakness and the drawing of the healthcare service delivery system, the greatest potential.

Introduction: The role of the fatty acid in the prevention or progression of chronic diseases has generated significant interest on the part of researchers. Thus, our objective was to evaluate the long-term effects of high-fat diet containing soybean or canola oil on body development and bone parameters of male rats. Methods: After weaning, rats were grouped and fed either a control diet (7S) or a high-fat diet containing soybean (19S) or canola oil (19C). Femur and lumbar vertebra (LV4) structure were determined at 180 days by dual-energy X-ray absorptiometry and computed tomography. Results: The groups showed similar food intake, body mass and length development. The bone parameters of the 19C were similar to the control group, while the 19S showed lower bone parameters when compared to the other groups. Conclusions: The high-fat diet containing soybean oil was unfavorable to bone structure, while the canola oil contributed bone health during the adult stage of life.

Introducción: El papel del ácido graso en la prevención o la progresión de las enfermedades crónicas ha generado un interés significativo por parte de los investigadores. Por lo tanto, nuestro objetivo fue evaluar los efectos a largo plazo de la dieta alta en grasas que contienen soja o aceite de canola en los parámetros de desarrollo del cuerpo y los huesos de ratas macho. Métodos: Después del destete, las ratas se agruparon y se alimentaron con una dieta control (7S) o una dieta alta en grasa que contiene soja (19S) o aceite de canola (19C). Fémur y vértebras lumbares (LV4) estructura se determinaron a los 180 días por absorciometría dual de rayos X y tomografía computarizada. Resultados: Los grupos mostraron similares ingesta de alimentos, la masa corporal y el desarrollo de longitud. Los parámetros óseos de la 19C fueron similares al grupo control, mientras que los 19S mostró parámetros óseos inferiores en comparación con los otros grupos. Conclusiones: La dieta alta en grasas que contiene aceite de soja fue desfavorable a la estructura ósea, mientras que el aceite de canola contribuyó salud de los huesos en la etapa adulta de la vida.

Foi realizada uma revisão não sistemática sobre a importância da discriminação fonêmica para a aquisição dos sons da fala e sua relação com o transtorno fonológico. Os estudos indicam que a discriminação fonêmica representa uma habilidade essencial no processo de aquisição dos sons da fala e que as crianças com transtorno fonológico apresentam dificuldade nesta habilidade.

It was performed a nonsystematic review on the importance of the phonemic discrimination to the phonological acquisition and its relation to the phonological disorder. Studies indicate that phonemic discrimination represents an essential ability in the process of acquiring sounds of speech and that children with phonological disorder present difficulties in that ability.

Este trabalho é fruto de uma pesquisa teórica sobre o ex-voto e suas repercussões na construção das subjetividades, considerando os referenciais da antropologia de Mauss e da psicanálise freudiana. A partir da contextualização da prática votiva e seus significados para o devoto e sua comunidade, entendemos o imaginário religioso como fonte de sentidos para o sujeito em padecimento, revelando formas típicas à cultura popular de compreensão dos vínculos sociais e das condições materiais de vida. Concluímos que, frente ao pathos que fundamenta o humano, o sujeito em sofrimento reage buscando cura e salvação para seus males pela intercessão de poderes superiores ligados ao sagrado. Apesar da não-implicação subjetiva no processo de vida, percebemos que os vínculos sociais forjados pelas obrigações de dar, receber e retribuir constituem uma ética, acolhendo o sujeito e sua comunidade em uma rede social propiciadora de sentidos às vicissitudes da existência.

This work is the result of a theoretical research on the ex-voto (Latin: in conformity with a promise) and its repercussions in the construction of subjectivities, considering the benchmarks of the anthropology of Mauss and Freudian psychoanalysis. From the context of the votive practice and its meanings to the devout and his community, we view the religious imagery as a source of senses to the subject who is suffering, showing the typical forms of popular culture of understanding the social ties and the material conditions of life. We conclude that, facing the pathos that substantiates the human being, the person who is suffering reacts seeking for cure and salvation for his ills through the intersection of superior powers linked to the sacred. Despite of the subjective non-involvement in the process of life, we realize that the social ties forged by the obligations of giving, receiving and returning constitute ethics, welcoming the subject in a social network that provides senses to the vicissitudes of existence.