Pesquisa | SciELO

ABSTRACT Purpose: To characterize the extracellular vesicle protein cargo in the aqueous humor and plasma of patients with ocular toxoplasmosis. Methods: Aqueous humor and plasma were collected from six patients with active ocular toxoplasmosis and six patients with cataract. Extracellular vesicles were isolated, and western blotting and mass spectrometry were performed for protein analysis. Results: All plasma samples from patients with ocular toxoplasmosis and cataract were positive for the tetraspanins CD63 and TSG101. However, the aqueous humor from patients with ocular toxoplasmosis was positive only for CD63. Sixty-seven new unreported proteins were identified in the aqueous humor and plasma of patients with the ocular toxoplasmosis and cataract. Of the 67 proteins, 10 and 7 were found only in the cataract and ocular toxoplasmosis groups, respectively. In general, these proteins were involved in immune system activation and retina homeostasis and were related to infections and retina-associated diseases. Conclusion: The distinct protein signatures between ocular toxoplasmosis and cataract may be helpful in the differential diagnosis of ocular toxoplasmosis. However, more studies are needed to better understand the role of these proteins in the pathogenesis of ocular toxoplasmosis. Purpose Methods isolated analysis Results CD CD6 TSG101 TSG However Sixtyseven Sixty seven 6 1 groups respectively general retinaassociated associated diseases Conclusion TSG10 TSG1

https://doi.org/10.5935/0004-2749.2023-0037

Emplastro com resíduo de caulim como alternativa à realidade amazônica na salvaguarda dos bens culturais
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Gonçalves, Angelina Lobato

; Maia, Ana Áurea Barreto

; Sanjad, Thais Alessandra Bastos Caminha

; Loureiro, Alexandre Maximo Silva

; Costa, Marcondes Lima da

Ambiente Construído

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Dez 2024, Volume 24 elocation e132697

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A conservação de bens culturais necessita estar alinhada com a política de sustentabilidade da atualidade. Assim, este trabalho teve como objetivo avaliar a eficácia do uso do resíduo do caulim substituindo total ou parcialmente a bentonita, na formulação de Mário Mendonça de Oliveira, para a limpeza de superfícies pétreas. E dessa forma avaliar possíveis alterações no aspecto ou na estrutura do lioz. Para tanto foram avaliadas a influência de algumas variáveis, como tempo de aplicação do emplastro e a concentração dos argilominerais utilizados. A metodologia experimental consistiu em: secagem e pulverização do resíduo; quantificação e pesagem dos reagentes; limpeza úmida da rocha; síntese, aplicação e remoção do emplastro. Ao longo da pesquisa foram empregadas técnicas de análise, para caracterizar os materiais de partida, os produtos formados e as alterações produzidas na superfície da rocha. Após a limpeza por via úmida houve uma tendência de elevação de brilho em todas as faixas estudadas; e um aumento do mesmo em todas as faixas em que foi aplicado o emplastro de 100% caulim, para os tempos de 7 e 14 dias. atualidade Assim bentonita Oliveira pétreas lioz variáveis utilizados reagentes rocha síntese análise partida estudadas 100 1 dias 10

Abstract The conservation of cultural heritage needs to be aligned with current sustainability policies. Therefore, this work aimed to assess the effectiveness of using kaolin residue, either totally or partially replacing bentonite, in Mário Mendonça de Oliveira's formulation for cleaning stone surfaces, in order to measure possible changes in the appearance or structure of Lioz stone. The influence of some variables, such as the application time of the plaster and the concentration of the clay minerals used, was evaluated. The experimental methodology consisted of drying and pulverizing the residue; quantifying and weighing the reagents; wet cleaning the rock; synthesis, application, and removal of the plaster. Throughout the research, analysis techniques were employed to characterize the starting materials, the products formed, and the alterations produced on the rock surface. After the wet cleaning process, there was a trend for increased brightness in all studied ranges, and an increase in brightness in all ranges where 100% kaolin plaster was applied during 7 and 14 days. policies Therefore residue bentonite Oliveiras Oliveira s surfaces variables used evaluated reagents synthesis research materials formed surface process 100 1 days 10

https://doi.org/10.1590/s1678-86212024000100766

Potential of artificial intelligence to generate health research reports of decayed, missed and restored teeth
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Dantas Costa, Eliana

; Carneiro, José Andery

; Guerra Zancan, Breno Augusto

; Gaêta-Araujo, Hugo

; Oliveira-Santos, Christiano

; Macedo, Alessandra Alaniz

; Tirapelli, Camila

Odovtos International Journal of Dental Sciences

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Ago 2024, Volume 26 Nº 2 Páginas 14 - 19

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Este estudio tiene como objetivo indicar el potencial de la inteligencia artificial (IA) en los informes epidemiológicos de dientes cariados, perdidos y restaurados. Como prueba de concepto, nuestro modelo de estudio utilizó imágenes panorámicas de rayos X y un algoritmo de inteligencia artificial para la numeración de dientes, la detección de caries y las restauraciones con una precisión superior al 80 % para dichas tareas de diagnóstico. El resultado fue el número de dientes cariados, perdidos y restaurados según la edad del paciente y el índice CPOD (número de dientes cariados, perdidos y obturados) que varió de 3,6 (hasta 20 años) a 20,4 (+60 años). Por tanto, se sugiere que la IA es un método prometedor para automatizar la recopilación de datos de salud mediante el análisis de rayos X.

Abstract This study aims to indicate the potential of artificial intelligence (AI) in epidemiological reports of decayed, missed and restored teeth. As a proof of concept our study model used panoramic x-ray images and an AI algorithm for tooth numbering, detection of the caries and restorations with accuracy over 80% for such diagnostic tasks. The output came as the number of decayed, missed and restored teeth according to patient's age and the DMFT index (number of decayed, missing, and filled teeth) which varied from 3.6 (up to 20 years old) to 20.4 (+60 years old). Thus, it is suggested that AI is a promising method to automate health data collection through the analysis of x-rays.

https://doi.org/10.15517/ijds.2024.59184

Historical-Discursive Analysis of the Editorial "1964" in Folha de São Paulo HistoricalDiscursive Historical Discursive 1964 "1964 196 "196 19 "19 1 "1 "
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Santos, Cynthia Adrielle da Silva

; Costa, Alessandra

; Saraiva, Luiz Alex Silva

Organizações & Sociedade

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Jan 2024, Volume 31 Nº 108 Páginas 149 - 175

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O artigo tem por objetivo analisar o Editorial “1964” da Folha de São Paulo à luz da Abordagem Histórico-Discursiva (AHD), lastreando a discussão nos conceitos de discurso, mídia e história e a historiografia sobre imprensa e ditadura. Este texto, publicado em 30 de março de 2014, às vésperas do aniversário de cinquenta anos do golpe de 1964, se insere em um movimento mais amplo, que engloba também outros jornais da grande imprensa, de reavaliação e reescrita da sua história durante o período da ditadura militar brasileira (1964-1985). A metodologia empregou os oito estágios da AHD e suas cinco questões centrais. A partir da identificação de três macrotópicos dicotômicos (apoio à ditadura militar como erro versus apoio como longo e doloroso aprendizado; violências do regime versus realizações econômicas; e disputa entre socialismo revolucionário versus economia de mercado) e das estratégias discursivas utilizadas (predicação, argumentação, perspectiva, intensificação e mitigação), foi possível observar que o jornal discursivamente: a) invisibiliza os problemas causados pelo regime militar; b) enfatiza o crescimento econômico vivenciado pelo país no período e; c) justifica suas ações atrelando-as ao contexto da época, o que levanta questionamentos sobre o exame de sua posição. As principais conclusões sugerem que a ambiguidade com que a empresa se posiciona, de atenuação de sua contribuição para o regime militar e, ao tempo, de intensificação do seu papel democrático, faz sentido à luz da estratégia empresarial contextualizada e que deve ser considerada na discussão sobre as interfaces entre discurso, mídia e história. 1964 “1964 HistóricoDiscursiva Histórico Discursiva AHD, , (AHD) discurso texto 3 2014 amplo 19641985. 19641985 1985 . (1964-1985) centrais aprendizado econômicas mercado predicação, predicação (predicação argumentação perspectiva mitigação, mitigação mitigação) discursivamente b c atrelandoas atrelando época posição posiciona tempo democrático 196 “196 (AHD 201 1964198 198 (1964-1985 19 “19 20 196419 (1964-198 1 “1 2 19641 (1964-19 “ (1964-1 (1964- (1964 (196 (19 (1 (

Abstract The article aims to analyze the Folha de São Paulo editorial "1964" in the light of the historical-discursive approach (HDA), basing the discussion on the concepts of discourse, media and history, and the historiography of the press and dictatorship. This text, published on March 30, 2014, on the eve of the 50th anniversary of the 1964 coup, is part of a broader movement that also includes other newspapers of the mainstream press to reassess and rewrite their history during the period of the Brazilian military dictatorship (1964-1985). The methodology used was the eight stages of the HDA and its five central questions. By identifying three dichotomous macro-topics (support for the military dictatorship as a mistake versus support as a long and painful learning process; the regime's violence versus its economic achievements; and the dispute between revolutionary socialism versus the market economy) and the discursive strategies used (predication, argumentation, perspective, intensification, and mitigation), it was possible to observe that the newspaper discursively: (a) makes the problems caused by the military regime invisible; (b) emphasizes the economic growth that the country experienced during the period; and (c) justifies its actions by linking them to the context of the time, which raises questions about the examination of its position. The main conclusions suggest that the ambiguity with which the company positions itself, attenuating its contribution to the military regime and at the same time intensifying its democratic role, makes sense in the light of a contextualized business strategy and should be considered in the discussion about the interfaces between discourse, media and history. "1964 historicaldiscursive historical HDA, , (HDA) discourse text 30 2014 th 196 coup 19641985. 19641985 1985 . (1964-1985) macrotopics macro topics process regimes s achievements economy predication, predication (predication argumentation perspective intensification mitigation, mitigation mitigation) discursively (a invisible b (b c (c position itself role "196 (HDA 3 201 19 1964198 198 (1964-1985 "19 20 1 196419 (1964-198 "1 2 19641 (1964-19 " (1964-1 (1964- (1964 (196 (19 (1 (

https://doi.org/10.1590/1984-92302024v31n0005en

Comparing diabetes prediction based on metabolic dysfunction-associated steatotic liver disease and nonalcoholic fatty liver disease: the ELSA-Brasil study
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Lopes, Gabriela Wünsch

; Canhada, Scheine Leite

; Reis, Rodrigo Citton Padilha dos

; Diniz, Maria de Fátima Haueisen Sander

; Goulart, Alessandra Carvalho

; Faria, Luciana Costa

; Griep, Rosane Harter

; Perazzo, Hugo

; Duncan, Bruce Bartholow

; Schmidt, Maria Inês

Cadernos de Saúde Pública

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2024, Volume 40 Nº 11 elocation e00009924

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: Este estudo comparou as definições de doença hepática gordurosa não alcoólica (DHGNA) e doença hepática esteatótica associada à disfunção metabólica (DHEADM) em relação à predição de diabetes em uma grande população adulta de brasileiros. Como objetivo secundário, comparamos as associações entre DHGNA/DHEADM e diabetes em grupos de diferentes etnias/cor da pele autodeclaradas. O Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil) é um estudo de coorte prospectivo de servidores públicos brasileiros (35-74 anos) recrutados de 2008 a 2010 e acompanhados nos períodos de 2012-2014 e 2017-2019. Determinamos o diabetes mellitus tipo 2 nas visitas iniciais e de acompanhamento com base em diagnóstico autorreferido, uso de medicação e testes glicêmicos (glicemia em jejum e 2 horas após o teste de tolerância à glicose oral e HbA1c). Foram excluídos indivíduos com consumo pesado de álcool ou cirrose/hepatite autorreferida. Foram analisados 7.073 indivíduos. A DHGNA foi definida por esteatose através de ultrassom. Participantes com esteatose e pelo menos um fator cardiometabólico foram considerados como portadores de DHEADM. Modelos de riscos proporcionais de Cox foram aplicados para avaliar a associação entre DHGNA/DHEADM e a incidência de diabetes mellitus tipo 2. No início do estudo, 33,9% apresentavam DHGNA e 32,5% DHEADM. Ao longo de 9,4 anos de acompanhamento, o aumento relativo na incidência de diabetes foi de 78% para indivíduos com DHGNA (HR = 1,78; IC95%: 1,58-2,01) e 88% para indivíduos com DHEADM (HR = 1,88; IC95%: 1,67-2,12). As associações não diferiram significativamente entre os grupos de etnia/cor de pele (p para interação = 0,10 para DHEADM e 0,08 para DHGNA). Nesta grande coorte de brasileiros de meia-idade e idosos, a incidência relativa de diabetes foi semelhante nas definições de DHGNA e DHEADM, com associações semelhantes entre grupos étnicos.

Abstract: We aimed to compare nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) definitions concerning diabetes prediction in a large sample of Brazilian adults. As a secondary objective, we compared associations between NAFLD/MASLD and diabetes across self-declared race/skin color groups. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study of Brazilian civil servants (35-74 years) enrolled from 2008 to 2010 and followed up from 2012-2014 and 2017-2019. We ascertained type 2 diabetes mellitus at baseline as well as follow-up visits based on self-reported diagnosis, medication use, and glycemic tests (fasting and 2h post-OGTT glucose and HbA1c). We excluded individuals with heavy alcohol consumption or self-reported cirrhosis/hepatitis. We analyzed 7,073 subjects. NAFLD was defined by ultrasound-based steatosis. Participants with steatosis and at least one cardiometabolic factor were considered as having MASLD. Cox proportional hazards models were performed to evaluate the association between NAFLD/MASLD and the incidence of type 2 diabetes mellitus. At baseline, 33.9% of individuals presented NAFLD and 32.5% presented MASLD. Over 9.4 years of follow-up, the relative increase in the incidence of diabetes was 78% for NAFLD (HR = 1.78; 95%CI: 1.58-2.01) and 88% for MASLD (HR = 1.88; 95%CI: 1.67-2.12). Associations did not differ significantly among race/skin color groups (p for interaction = 0.10 for MASLD and 0.08 for NAFLD). In this large cohort of middle-aged and older Brazilian adults, the relative incidence of diabetes was similar for NAFLD and MASLD definitions, with similar associations in all ethnic groups.

Resumen: Este estudio comparó las definiciones de enfermedad del hígado graso no alcohólico (EHGNA) y enfermedad hepática esteatótica asociada con disfunción metabólica (EHDM) con relación a la predicción de diabetes en una gran población adulta de brasileños. Como objetivo secundario, comparamos las asociaciones entre EHGNA/MASLD y diabetes en grupos de diferentes etnias/color de piel autodeclarados. El Estudio Longitudinal de Salud del Adulto (ELSA-Brasil) es un estudio de cohorte prospectivo de servidores públicos brasileños (35-74 años) reclutados entre el 2008 y el 2010 y seguidos en los períodos 2012-2014 y 2017-2019. Determinamos la diabetes mellitus tipo 2 en las visitas iniciales y de seguimiento con base en el diagnóstico autoinformado, el uso de medicación y las pruebas de glucemia (glucemia en ayunas y prueba de tolerancia a la glucosa oral 2 horas después y HbA1c). Se excluyeron las personas con consumo excesivo de alcohol o cirrosis/hepatitis autoinformadas. Se analizaron 7.073 individuos. La EHGNA se definió por esteatosis mediante ecografía. Se consideró que los participantes con esteatosis y al menos un factor cardiometabólico tenían EHDM. Se aplicaron modelos de riesgos proporcionales de Cox para evaluar la asociación entre EHGNA/EHDM y la incidencia de diabetes mellitus tipo 2. Al inicio del estudio, el 33,9% tenía EHGNA y el 32,5% EHDM. Durante 9,4 años de seguimiento, el aumento relativo en la incidencia de diabetes fue del 78% para las personas con EHGNA (HR = 1,78; IC95%: 1,58-2,01) y del 88% para las personas con EHDM (HR = 1,88; IC95%: 1,67-2,12). Las asociaciones no difirieron significativamente entre los grupos étnicos/color de piel (p para interacción = 0,10 para EHDM y 0,08 para EHGNA). En esta gran cohorte de brasileños de mediana edad y ancianos, la incidencia relativa de diabetes fue similar en las definiciones de EHGNA y EHDM, con asociaciones similares entre grupos étnicos.

https://doi.org/10.1590/0102-311xen009924

Relationship between permanent upper anterior teeth and anthropometric facial measures in different populations: a narrative review populations
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Longhi, Maria Tereza de Moraes

; Silva, Rafaella Ugrin de Oliveira

; Almeida, Sâmara Cafa Silva

; Esteves, Alessandra

; Rossi Júnior, Wagner Costa

; Figueiredo, Camila Helena Machado da Costa

; Andrade, Ana Luiza Dias Leite de

Brazilian Journal of Oral Sciences

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2024, Volume 23 elocation e248788

Resumo: En | Texto: En | PDF: En

Aim The main purpose of this study was to conduct a narrative review investigating the possible relationship between permanent maxillary anterior teeth and anthropometric facial parameters in different populations. Methods Searches were performed in the PubMed, BVS (Biblioteca Virtual em Saúde) and SciELO databases to identify relevant scientific articles using the following search terms: “maxillary anterior teeth”, “facial measurements” and “anthropometry”, in such a way that 218 publications were found. After application of inclusion and exclusion criteria, 13 publications remained for full-text reading. Results All studies involved male and female samples and it was notorious that male measurements were unanimously higher than those obtained in the opposite sex. The age of the analyzed participants ranged from 17 to 60 years; however, a mean age of 18 to 25 years was the most investigated in literature. In addition, facial measurements including the bizygomatic width, interpupillary distance, intercanthal distance, interalar width and intercommissural width have been proposed to help determine the correct size of anterior teeth. Conclusion It was concluded that despite the limited number of studies, some factors that influence dental and facial dimensions, such as sex and age, can be identified. However, there is no standardization of the facial or dental parameters used in the studies, a fact that makes it difficult to establish a universal ratio for clinical dental practice. populations PubMed Biblioteca Saúde terms teeth, , teeth” anthropometry, anthropometry “anthropometry” 21 found criteria 1 fulltext full text reading 6 however 2 literature addition distance dimensions identified However practice “anthropometry

https://doi.org/10.20396/bjos.v23i00.8668788

Implications of clinical simulation in motivation for learning: scoping review learning
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Henrique-Sanches, Barbara Casarin

; Cecilio-Fernandes, Dario

; Costa, Raphael Raniere de Oliveira

; Almeida, Rodrigo Guimarães dos Santos

; Etchegoyen, Federico Ferrero

; Mazzo, Alessandra

einstein (São Paulo)

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2024, Volume 22 elocation RW0792

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To identify, synthesize, and analyze the scientific knowledge produced regarding the implications of using clinical simulation for undergraduate nursing or medical students' motivation for learning. Methods: The search for articles was conducted between July 28 and August 3, 2022, on the PubMed/MEDLINE, Scopus, Web of Science, and SciELO databases. The following was used for the search: P - undergraduate students attending Nursing or Medicine courses; C - motivation for learning, and C - skills and clinical simulation laboratory. The following research question guided the study: “What are the implications of clinical simulation on the motivation for learning of undergraduate students of nursing and medicine?” Of the 1,783 articles found, 13 were included in the sample for analysis. All stages of the selection process were carried out by two independent evaluators. The results were presented as charts and a discursive report. Results: The studies analyzed indicated the beneficial effects of clinical simulation on students' motivation, in addition to other gains such as competencies, technical and non-technical skills, knowledge, belonging, autonomy, clinical judgment, critical and reflective thinking, self-efficacy and decreased anxiety, self-management, and improvements in learning and learning climate. Conclusion: Clinical simulation provides a positive learning environment favorable to the development of technical and interpersonal skills and competencies, and raising the level of motivational qualities. Objective identify synthesize Methods 2 3 2022 PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE Scopus Science databases courses laboratory study What medicine medicine? 1783 1 783 1,78 found analysis evaluators report Results competencies nontechnical non belonging autonomy judgment thinking selfefficacy self efficacy anxiety selfmanagement, selfmanagement management, management self-management climate Conclusion qualities 202 178 78 1,7 20 17 7 1,

https://doi.org/10.31744/einstein_journal/2024rw0792

Durability monitoring of existing reinforced concrete structures: concepts, advancements, and prospects structures concepts advancements
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Costa, Alessandra Augusto

; Quarcioni, Valdecir Angelo

Revista IBRACON de Estruturas e Materiais

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2024, Volume 17 Nº 6 elocation e17614

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este artigo explora os conceitos essenciais relacionados à durabilidade de estruturas de concreto armado existentes, com vistas ao seu monitoramento. Compara a abordagem atual adotada em grandes obras com aquela aplicada às demais estruturas em serviço. Apresenta os princípios do Structure Health Monitoring (SHM) e explora diversas soluções de sensores disponíveis no mercado e desenvolvidas em projetos de pesquisa. Destaca a viabilidade de democratizar o monitoramento estrutural, atualmente limitado por barreiras culturais. Para isso, enfatiza a necessidade de colaboração entre profissionais técnicos, pesquisadores, entidades de classe e órgãos governamentais, a fim de superar os desafios que levaram ao chamado “apagão” de controle no conjunto construído. existentes serviço SHM (SHM pesquisa estrutural culturais isso técnicos pesquisadores governamentais apagão “apagão construído

Abstract This article explores the fundamental concepts related to the durability of existing reinforced concrete structures, focusing on its monitoring. It compares the current approach adopted in major projects with that applied to other structures in service. It presents the principles of Structural Health Monitoring (SHM) and examines various sensor solutions available on the market and developed in research projects. It emphasizes the feasibility of democratizing structural monitoring, which is currently limited by cultural barriers. To achieve this, it highlights the need for collaboration among technical professionals, researchers, professional associations, and government agencies to overcome the challenges that have led to the so-called “control blackout” in the built environment. monitoring service SHM (SHM barriers this professionals researchers associations socalled so called control blackout environment

https://doi.org/10.1590/s1983-41952024000600014

Human papillomavirus in women infected with human immunodeficiency virus: association with viral load and lymphocyte count virus
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Morais, Ana Cléa Cutrim Diniz de

; Ferreira, Alice de Sá

; Barbosa, Carla Déa Trindade

; Lima, Maria Fernanda Bezerra

; Fook, Karina Donato

; Carvalho, Mônika Machado de

; Muniz, Alessandra Costa de Sales

; Araújo, Deborah Rocha de

; Monteiro, Pablo de Matos

; Araújo, Maria José Abigail Mendes

; Monteiro, Sally Cristina Moutinho

; Lopes, Fernanda Ferreira

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e36

Resumo: En | Texto: En | PDF: En

ABSTRACT Women living with human immunodeficiency virus are at an increased risk of developing cancers related to human papillomavirus (HPV). Thus, it is important to combine clinical assessments, serological screening, and HPV data for planning prevention policies. This study aimed to identify HPV and its specific types in the cervical, anal, and oral mucosa of HIV-seropositive women, associating it with viral load and lymphocyte count. Sociodemographic characteristics, health data (CD4+ and CD8+ T cell counts and viral load), and biological samples (cervical, anal, and oral) were collected from 86 HIV-positive women undergoing antiretroviral therapy. Data were classified according to the presence or absence of HPV-DNA, HPV-DNA presence at one or more anatomic sites, and level of oncogenic risk, considering low- and high-risk oncogenic HPV-DNA groups. The presence of HPV in the cervicovaginal site was 65.9%, 63.8% in anal canal, and 4.2% in oral mucosa. A viral load ≥75 HIV copies/mL was associated with the presence of HPV-DNA. There was an association between viral load and the low-risk HPV or high-risk HPV groups. We found a high prevalence of HPV infection in HIV-seropositive women, particularly in the cervical and anal mucosa, with viral load ≥75 HIV copies/mL being associated with HPV-DNA presence. HPV. . (HPV) Thus assessments screening policies HIVseropositive seropositive count characteristics CD4+ CD4 CD (CD4 CD8 load, , load) (cervical 8 HIVpositive positive therapy HPVDNA, HPVDNA DNA, DNA sites low highrisk groups 659 65 9 65.9% 638 63 63.8 canal 42 4 2 4.2 75 ≥7 copiesmL copies mL HPVDNA. DNA. lowrisk (HPV (CD 6 65.9 63. 4. 7 ≥ 65.

https://doi.org/10.1590/s1678-9946202466036

10.

Construction and validation of the community health workers perception questionnaire on conditions amenable to physiotherapy in primary health care
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Silva, Gabriel Brighenti Menezes

; Barbosa, Samara Maria Neves

; Figueiredo, Eduardo Augusto Barbosa

; Costa, Henrique Silveira

; Bastone, Alessandra de Carvalho

; Santos, Juliana Nunes

Fisioterapia em Movimento

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2024, Volume 37 elocation e37101

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução O Agente Comunitário de Saúde (ACS), assim como o fisioterapeuta, desencadeia funções fundamentais na Atenção Primária à Saúde (APS), sendo ele-mento importante na transformação de políticas públicas. Inexistem estudos que investiguem o conhecimento dos ACS sobre as condições de saúde sensíveis à inter-venção da fisioterapia na APS. Objetivo Construir um questionário de investigação da percepção dos ACS sobre as condições de saúde sensíveis à intervenção da fisioterapia na APS. Métodos Trata-se de um estudo metodológico no qual, inicialmente, construiu-se uma matriz de análise com o intuito de englobar as ideias contempladas no questionário. Para a construção do instrumento, realizou-se uma revisão da literatura, sendo eleitas condições de saúde sensíveis à intervenção da fisioterapia na APS. Para a validação de conteúdo e aparente dos itens, 12 fisioterapeutas especialistas em APS julgaram a adequação dos itens contidos. Utilizou-se o índice de validade de conteúdo para verificar o grau de concordância durante o processo de análise das respos-tas. Posteriormente, realizou-se análise semântica por meio da compreensão dos itens por 15 ACS. Na etapa de validação, foram realizadas duas rodadas de avaliação. Foram feitos ajustes em 17 questões. Resultados O estudo resultou em um questionário com 20 questões contendo situações hipotéticas de visitas domiciliares, cuja situação do morador poderia ou não configurar um risco à saúde sensível à intervenção fisioterapêutica. Conclusão O instrumento de percepção dos ACS sobre as condições de saúde sensíveis à intervenção da fisioterapia na APS mostrou-se válido para ser utilizado no contexto da APS. A utilização do instrumento poderá contribuir na elaboração de programas de capacitação dos ACS, com o intuito de facilitar a comunicação da equipe. , (ACS) fisioterapeuta APS, (APS) elemento ele mento públicas inter venção Tratase Trata se qual inicialmente construiuse construiu realizouse realizou literatura 1 contidos Utilizouse Utilizou respostas. respostas respos tas. tas respos-tas Posteriormente avaliação 2 domiciliares fisioterapêutica mostrouse mostrou equipe (ACS (APS

Abstract Introduction Community health workers, like the physiotherapist, perform essential functions in primary health care, being an important element in the transformation of public policies. There are no reported studies investigating the knowledge of community health workers about health conditions amenable to physiotherapy intervention in primary health care. Objective To construct a questionnaire to investigate the perception of community health workers about health conditions that could be remedied by physiotherapy intervention in primary health care. Methods This was a methodological study in which it was initially an analysis matrix with the aim of encompassing the ideas contemplated in the questionnaire. To construct the instrument, a literature review was carried out, and health conditions treatable with physiotherapy in primary health care were chosen. To validate the content and appearance of the items, twelve physiotherapists specialized in primary health care judged the suitability of the items contained. The content validity index was used to determine the degree of agreement during the response analysis process. Subsequently, a semantic analysis was carried out through the understanding of the items by 15 community health workers. In the validation stage, two rounds of evaluation were carried out. Adjustments were made to 17 questions. Results The study investigated a questionnaire with 20 questions containing hypothetical situations of home visits, in which the resident's situation could or could not constitute a health risk amenable to physiotherapeutic intervention. Conclusion The community health workers perception instrument on health conditions amenable to physiotherapy intervention in primary health care proved to be valid for use in this context. The use of the instrument may contribute to the development of community health worker training programs, with the aim of facilitating team communication. physiotherapist policies chosen contained process Subsequently 1 stage 2 visits residents resident s context programs communication

https://doi.org/10.1590/fm.2024.37101

11.

COVID-19 in hematopoietic stem cell transplant recipients during three years of the pandemic: a multicenter study in Brazil COVID19 COVID 19 COVID-1 pandemic COVID1 1 COVID-
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Randi, Bruno Azevedo

; Higashino, Hermes Ryoiti

; Silva, Vinícius Ponzio da

; Salomão, Matias Chiarastelli

; Pignatari, Antonio Carlos Campos

; Abdala, Edson

; Vasques, Fabiana

; Silva, Celso Arrais Rodrigues da

; Silva, Roberto Luiz da

; Lazari, Carolina dos Santos

; Levi, José Eduardo

; Xavier, Erick Menezes

; Côrtes, Marina Farrel

; Luna-Muschi, Alessandra

; Rocha, Vanderson

; Costa, Silvia Figueiredo

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e17

Resumo: En | Texto: En | PDF: En

ABSTRACT Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022. The primary outcome was all-cause mortality. Of 49 cases, 63.2% were male with a median age of 47 years. Allogeneic-HSCT (51.2%) and autologous-HSCT (48.9%) patients were included. The median time from HSCT to COVID-19 diagnosis was 398 days (IQR: 1211-134), with 22 (44.8%) cases occurring within 12 months of transplantation. Most cases occurred during the first year of the pandemic, in non-vaccinated patients (n=35; 71.4%). Most patients developed severe (24.4%) or critical (40.8%) disease; 67.3% received some medication for COVID-19, primarily corticosteroids (53.0%). The probable invasive aspergillosis prevalence was 10.2%. All-cause mortality was 40.8%, 51.4% in non-vaccinated patients and 14.2% in patients who received at least one dose of the vaccine. In the multiple regression analyses, the variables mechanical ventilation (OR: 101.01; 95% CI: 8.205 – 1,242.93; p = 0.003) and chest CT involvement at diagnosis ≥50% (OR: 26.61; 95% CI: 1.06 – 664.26; p = 0.04) remained associated with all-cause mortality. Thus, HSCT recipients with COVID-19 experienced high mortality, highlighting the need for full vaccination and infection prevention measures. (HSCT increased COVID19. COVID19 COVID 19. 19 COVID-1 Paulo postHSCT, postHSCT post HSCT, post-HSCT 202 2022 allcause all cause 4 632 63 2 63.2 years AllogeneicHSCT Allogeneic 51.2% 512 51 (51.2% autologousHSCT autologous 48.9% 489 48 9 (48.9% included 39 IQR (IQR 1211134, 1211134 1211 134 , 1211-134) 44.8% 448 44 8 (44.8% 1 transplantation pandemic nonvaccinated non vaccinated n=35 n35 n 35 (n=35 71.4%. 714 71.4% . 71 71.4%) 24.4% 244 24 (24.4% 40.8% 408 40 (40.8% disease 673 67 3 67.3 COVID19, 19, 53.0%. 530 53.0% 53 0 (53.0%) 102 10 10.2% Allcause All 514 51.4 142 14 14.2 vaccine analyses OR (OR 101.01 10101 101 01 95 CI 8205 205 8.20 1,242.93 124293 242 93 0.003 0003 003 50 ≥50 26.61 2661 26 61 106 06 1.0 664.26 66426 664 0.04 004 04 Thus measures COVID1 COVID- 20 6 63. 51.2 5 (51.2 48.9 (48.9 121113 121 13 1211-134 44.8 (44.8 n=3 n3 (n=3 71.4 7 24.4 (24.4 40.8 (40.8 67. 53.0 (53.0% 10.2 51. 14. 101.0 1010 820 8.2 1,242.9 12429 0.00 000 00 ≥5 26.6 266 1. 664.2 6642 66 0.0 (51. 48. (48. 12111 1211-13 44. (44. n= (n= 71. 24. (24. 40. (40. 53. (53.0 10. 101. 82 8. 1,242. 1242 ≥ 26. 664. 0. (51 (48 1211-1 (44 (n (24 (40 (53. 1,242 124 (5 (4 1211- (2 (53 1,24 ( 1,2 1,

https://doi.org/10.1590/s1678-9946202466017

12.

Labor gymnastics in health professionals: a systematic review professionals
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Costa, Lara Maria Camilato Lima

; Pimenta, Isadora Caroline

; Sales, Erika Moreira

; Vidal, Alessandra Paiva de Castro

; Martins, Lisandra Vanessa

Fisioterapia e Pesquisa

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2024, Volume 31 elocation e23002324en

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Este estudo tem como objetivo revisar sistematicamente ensaios randomizados controlados e comparar a eficácia da ginástica laboral com nenhuma intervenção, intervenção mínima ou outros tipos de intervenção em trabalhadores de saúde, em relação à dor musculoesquelética, estresse, incapacidade física e afastamento do trabalho. Foram realizadas buscas nas bases de dados PUBMED, PEDro, EMBASE, CENTRAL, CINAHAL, PsycINFO, NIOSHTIC-2, SPORTDicus, SCIELO e LILACS. Foram encontrados 3598 artigos, sendo sete elegíveis. Houve diferença estatística para dor musculoesquelética a favor da ginástica laboral após 5, 10 e 12 semanas (MD: −0,63; 95%, CI: −1,17; −0,08) e 6,9 e 12 meses de intervenção (MD: −0,74; 95% CI: −1,43; −0,05). Também foi verificada diferença estatística a favor da ginástica laboral para o afastamento no trabalho (MD: −3,26; 95% IC: −6,28; −0,25) e para redução do estresse (SMD: −0.35; 95% IC: −0,67; −0.03) nos estudos que realizaram intervenção por 5 e 10 semanas. A ginástica laboral pode contribuir para a saúde física e mental do profissional de saúde, no entanto, mais estudos randomizados controlados voltados para essa categoria profissional, e com maior valor amostral, são necessários para confirmação dessa hipótese. PUBMED PEDro EMBASE CENTRAL CINAHAL PsycINFO NIOSHTIC2, NIOSHTIC2 NIOSHTIC 2, 2 NIOSHTIC-2 SPORTDicus LILACS 359 artigos elegíveis 1 MD (MD −0,63 063 0 63 95 CI −1,17 117 17 −0,08 008 08 69 6 9 6, −0,74 074 74 −1,43 143 43 −0,05. 005 −0,05 . 05 −0,05) −3,26 326 3 26 IC −6,28 628 28 −0,25 025 25 SMD (SMD −0.35 035 35 −0,67 067 67 −0.03 003 03 entanto amostral hipótese NIOSHTIC- −0,6 06 −1,1 11 −0,0 00 −0,7 07 7 −1,4 14 4 −3,2 32 −6,2 62 −0,2 02 −0.3 −0.0 −0, −1, −3, −6, −0. −0 −1 −3 −6 −

ABSTRACT This aimed to systematically review randomized controlled trials and compare the effectiveness of labor gymnastics with that of no intervention, minimal intervention or other types of intervention in healthcare workers, in relation to musculoskeletal pain, stress, physical disability, and absence from work. A search was carried out in the PUBMED, Pedro, EMBASE, CENTRAL, CINAHAL, PSYCHINFO, NIOSHTIC-2, SPORT DICUS, SCIELO, and LILACS databases. In total, 3,598 articles were found, seven of which were eligible for the study. There was a statistical difference in musculoskeletal pain in favor of labor gymnastics after 5, 10 and 12 weeks (MD: −0.63; 95%, CI: −1.17; −0.08) and 6, 9 and 12 months of intervention (MD: −0.74; 95% CI: −1.43; −0.05). There was also a statistical difference in favor of labor gymnastics in terms of time off work (MD: −3.26; 95% CI: −6.28; −0.25) and stress (SMD: −0.35; 95% CI: −0.67; −0.03) in studies in which interventions were carried out for 5 and 10 weeks. Labor gymnastics can contribute to the physical and mental health of healthcare professionals. However, more randomized controlled studies with a larger sample size and aimed at this professional category are needed. workers disability PUBMED Pedro EMBASE CENTRAL CINAHAL PSYCHINFO NIOSHTIC2, NIOSHTIC2 NIOSHTIC 2, 2 NIOSHTIC-2 DICUS SCIELO databases total 3598 3 598 3,59 found study 1 MD (MD −0.63 063 0 63 95 CI −1.17 117 17 −0.08 008 08 6 −0.74 074 74 −1.43 143 43 −0.05. 005 −0.05 . 05 −0.05) −3.26 326 26 −6.28 628 28 −0.25 025 25 SMD (SMD −0.35 035 35 −0.67 067 67 −0.03 003 03 professionals However needed NIOSHTIC- 359 59 3,5 −0.6 06 −1.1 11 −0.0 00 −0.7 07 7 −1.4 14 4 −3.2 32 −6.2 62 −0.2 02 −0.3 3, −0. −1. −3. −6. −0 −1 −3 −6 −

RESUMEN Este estudio tuvo por objetivo realizar una revisión sistemática de los ensayos aleatorizados controlados y comparar la efectividad de la gimnasia laboral con ninguna intervención, con intervención mínima u otros tipos de intervención en los profesionales de la salud con relación a dolor musculoesquelético, estrés, incapacidad física y baja laboral. Se realizaron búsquedas en las bases de datos PUBMED, PEDro, EMBASE, CENTRAL, CINAHAL, PsycINFO, NIOSHTIC-2, SPORTDicus, SciELO y LILACS. Se encontraron 3.598 artículos, de los cuales siete fueron elegibles. Hubo una diferencia estadística para el dolor musculoesquelético a favor de la gimnasia laboral después de 5, 10 y 12 semanas (MD: −0,63; 95% CI: −1,17; −0,08) y 6,9 y 12 meses de intervención (MD: −0,74; 95% CI: −1,43; −0,05). También hubo una diferencia estadística a favor de la gimnasia laboral para el tiempo de baja laboral (MD: −3,26; 95% IC: −6,28; −0,25) y la reducción del estrés (SMD: −0,35; 95% IC: −0,67; −0,03) en los estudios que realizaron la intervención entre cinco y diez semanas. La gimnasia laboral puede contribuir a la salud física y mental de los profesionales de la salud, sin embargo, son necesarios más estudios aleatorizados controlados dirigidos a esta categoría profesional y con un mayor tamaño muestral para confirmar esta hipótesis. PUBMED PEDro EMBASE CENTRAL CINAHAL PsycINFO NIOSHTIC2, NIOSHTIC2 NIOSHTIC 2, 2 NIOSHTIC-2 SPORTDicus LILACS 3598 3 598 3.59 artículos elegibles 5 1 MD (MD −0,63 063 0 63 95 CI −1,17 117 17 −0,08 008 08 69 6 9 6, −0,74 074 74 −1,43 143 43 −0,05. 005 −0,05 . 05 −0,05) −3,26 326 26 IC −6,28 628 28 −0,25 025 25 SMD (SMD −0,35 035 35 −0,67 067 67 −0,03 003 03 embargo hipótesis NIOSHTIC- 359 59 3.5 −0,6 06 −1,1 11 −0,0 00 −0,7 07 7 −1,4 14 4 −3,2 32 −6,2 62 −0,2 02 −0,3 3. −0, −1, −3, −6, −0 −1 −3 −6 −

https://doi.org/10.1590/1809-2950/e23002324en

13.

The treatment of diabetic macular edema with intravitreal bevacizumab in users of the Brazilian public health system
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Ibrahim, Larissa Fouad

; Soares, Aleida Nazareth

; Costa, Lucas Assis

; Domingues, Thabata Machado Correia

; Souza, Alessandra Hubner de

Arquivos Brasileiros de Oftalmologia

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2024, Volume 87 Nº 5 elocation e2024-0146

Resumo: En | Texto: En | PDF: En

https://doi.org/10.5935/0004-2749.2024-0146

14.

Brazilian consensus recommendations on the diagnosis and treatment of autoimmune encephalitis in the adult and pediatric populations
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Dutra, Lívia Almeida

; Silva, Pedro Victor de Castro

; Ferreira, João Henrique Fregadolli

; Marques, Alexandre Coelho

; Toso, Fabio Fieni

; Vasconcelos, Claudia Cristina Ferreira

; Brum, Doralina Guimarães

; Pereira, Samira Luisa dos Apóstolos

; Adoni, Tarso

; Rocha, Leticia Januzi de Almeida

; Sampaio, Leticia Pereira de Brito

; Sousa, Nise Alessandra de Carvalho

; Paolilo, Renata Barbosa

; Pizzol, Angélica Dal

; Costa, Bruna Klein da

; Disserol, Caio César Diniz

; Pupe, Camila

; Valle, Daniel Almeida do

; Diniz, Denise Sisterolli

; Abrantes, Fabiano Ferreira de

; Schmidt, Felipe da Rocha

; Cendes, Fernando

; Oliveira, Francisco Tomaz Meneses de

; Martins, Gabriela Joca

; Silva, Guilherme Diogo

; Lin, Katia

; Pinto, Lécio Figueira

; Santos, Mara Lúcia Schimtz Ferreira

; Gonçalves, Marcus Vinícius Magno

; Krueger, Mariana Braatz

; Haziot, Michel Elyas Jung

; Barsottini, Orlando Graziani Povoas

; Nascimento, Osvaldo José Moreira do

; Nóbrega, Paulo Ribeiro

; Proveti, Priscilla Mara

; Castilhos, Raphael Machado do

; Daccach, Vanessa

; Glehn, Felipe von

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 Nº 7 elocation s00441788586

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes Encefalites autoimunes (EAIs) são um grupo de doenças inflamatórias caracterizadas pela presença de anticorpos contra antígenos neuronais e gliais, que ocasionam sintomas psiquiátricos subagudos, queixas de memória e distúrbios anormais do movimento. A maioria dos pacientes é jovem, e o atraso no tratamento está associado a pior prognóstico. Objetivo Com o apoio da Academia Brasileira de Neurologia (ABN) e da Sociedade Brasileira de Neurologia Infantil (SBNI), desenvolvemos um consenso sobre o diagnóstico e o tratamento da EAIs no Brasil utilizando a metodologia Delphi. Métodos Um total de 25 especialistas, incluindo neurologistas e neurologistas infantis, foram convidados a participar. Resultados Os especialistas concordaram que os pacientes com critérios de possíveis EAIs devem ser submetidos ao rastreio de anticorpos antineuronais no soro e no líquido cefalorraquidiano (LCR) por meio das técnicas de ensaio baseado em tecidos (tissue-based assay, TBA, em inglês) e ensaio baseado em células (cell-based assay, CBA, em inglês). As crianças também devem ser submetidas ao rastreio de de anticorpo contra a glicoproteína da mielina de oligodendrócitos (anti-myelin oligodendrocyte glycoprotein, anti-MOG, em inglês). O tratamento deve ser iniciado dentro das primeiras 4 semanas dos sintomas, sendo as opções de primeira linha metilprednisolona combinada com imunoglobulina intravenosa (IGIV) ou plasmaférese. O tratamento de segunda linha inclui rituximabe e ciclofosfamida. Bortezomib e tocilizumab são opções de tratamento de terceira linha. A maioria das crises epilépticas nas EAIs são sintomáticas, e os fármacos anticrise podem ser desmamadas após a fase aguda. Em relação à encefalite antirreceptor de N-metil-D-aspartato (anti-N-methyl-D-aspartate receptor, anti-NMDAR, em inglês), os especialistas concordaram que agentes imunossupressores orais não devem ser usados. Os pacientes devem ser avaliados na fase aguda e pós-aguda mediante escalas funcionais e cognitivas, como Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Modified Rankin Scale (mRS), e Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusão Esta pesquisa oferece evidências tangíveis do manejo efetivo de pacientes com EAIs no sistema de saúde Brasileiro. (EAIs gliais subagudos movimento jovem prognóstico ABN (ABN SBNI, SBNI , (SBNI) Delphi 2 infantis participar LCR (LCR tissuebased tissue based assay TBA inglês cellbased cell CBA inglês. . antimyelin anti myelin glycoprotein antiMOG, antiMOG MOG, MOG anti-MOG IGIV (IGIV plasmaférese ciclofosfamida sintomáticas NmetilDaspartato N metil D aspartato antiNmethylDaspartate methyl aspartate receptor antiNMDAR, antiNMDAR NMDAR, NMDAR anti-NMDAR inglês, usados pósaguda pós cognitivas MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) Brasileiro (SBNI (MMSE (MoCA (mRS (CASE

Abstract Background Autoimmune encephalitis (AIE) is a group of inflammatory diseases characterized by the presence of antibodies against neuronal and glial antigens, leading to subacute psychiatric symptoms, memory complaints, and movement disorders. The patients are predominantly young, and delays in treatment are associated with worse prognosis. Objective With the support of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, ABN) and the Brazilian Society of Child Neurology (Sociedade Brasileira de Neurologia Infantil, SBNI), a consensus on the diagnosis and treatment of AIE in Brazil was developed using the Delphi method. Methods A total of 25 panelists, including adult and child neurologists, participated in the study. Results The panelists agreed that patients fulfilling criteria for possible AIE should be screened for antineuronal antibodies in the serum and cerebrospinal fluid (CSF) using the tissue-based assay (TBA) and cell-based assay (CBA) techniques. Children should also be screened for anti-myelin oligodendrocyte glucoprotein antibodies (anti-MOG). Treatment should be started within the first 4 weeks of symptoms. The first-line option is methylprednisolone plus intravenous immunoglobulin (IVIG) or plasmapheresis, the second-line includes rituximab and/or cyclophosphamide, while third-line treatment options are bortezomib and tocilizumab. Most seizures in AIE are symptomatic, and antiseizure medications may be weaned after the acute stage. In anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the panelists have agreed that oral immunosuppressant agents should not be used. Patients should be evaluated at the acute and postacute stages using functional and cognitive scales, such as the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Modified Rankin Scale (mRS), and the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusion The present study provides tangible evidence for the effective management of AIE patients within the Brazilian healthcare system. (AIE antigens symptoms complaints disorders young prognosis Academia ABN Sociedade Infantil SBNI, SBNI , SBNI) method 2 neurologists CSF (CSF tissuebased tissue based TBA (TBA cellbased cell CBA (CBA techniques antimyelin anti myelin antiMOG. antiMOG MOG . (anti-MOG) firstline line IVIG (IVIG plasmapheresis secondline second andor cyclophosphamide thirdline third tocilizumab symptomatic stage antiNmethylDaspartate N methyl D aspartate antiNMDAR NMDAR (anti-NMDAR used scales MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) system (anti-MOG (MMSE (MoCA (mRS (CASE

https://doi.org/10.1055/s-0044-1788586

15.

Impact of waitlist time on post-HSCT survival: a cohort study at a hospital in southern Brazil postHSCT post HSCT survival
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Silva, Tatiana Schnorr

; Horvath, Jaqueline Driemeyer Correia

; Pereira, Mariana Pinto

; David, Caroline Nespolo de

; Vargas, Dora Fraga

; Rigoni, Lisandra Della Costa

; Sartor, Ivaine Tais Sauthier

; Kern, Luciane Beatriz

; Silva, Priscila de Oliveira da

; Paz, Alessandra Aparecida

; Daudt, Liane Esteves

; Astigarraga, Claudia Caceres

Hematology, Transfusion and Cell Therapy

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2024, Volume 46 Nº 3 Páginas 242 - 249

Resumo: En | Texto: En | PDF: En

Abstract Introduction The time elapsed from diagnosis to hematopoietic stem cell transplantation (HSCT) is influenced by numerous factors. In Brazil, patients using the public health system are also dependent on the availability of HSCT-specific beds in the hematology ward. Objective and Methods We conducted a cohort study of listed patients who underwent allogeneic HSCT at a Brazilian public hospital to investigate the impact of the waitlist time on post-HSCT survival. Results The median time from diagnosis to HSCT was 19 months (IQR, 10 - 43), of which 6 months (IQR, 3 - 9) were spent on the waitlist. The time on the waitlist for HSCT appeared to influence mainly the survival of adult patients (≥ 18 years), with an increasing risk according to this time (RR, 3.53 and 95%CI, 1.81 - 6.88 for > 3 and ≤ 6 months; RR 5.86 and 95%CI, 3.26 - 10.53 for > 6 and ≤ 12 months, and; RR 4.24 and 95%CI, 2.32 - 7.75 for > 12 months). Conclusion Patients who remained on the waitlist for less than 3 months had the highest survival (median survival, 856 days; IQR, 131 - 1607). The risk of reduced survival was about 6-fold higher (95%CI, 2.8 - 11.5) in patients with malignancies. (HSCT factors Brazil HSCTspecific specific ward postHSCT post 1 IQR (IQR 43, 43 , 43) 9 ≥ ( years, years years) RR, (RR 353 53 3.5 95CI CI 95 95%CI 181 81 1.8 688 88 6.8 586 5 86 5.8 326 26 3.2 1053 10.5 424 4 24 4.2 232 2 32 2.3 775 7 75 7.7 months. . months) 85 days 13 1607. 1607 1607) 6fold fold (95%CI 28 8 2. 11.5 115 11 malignancies 35 3. 1. 68 6. 58 5. 105 10. 42 4. 23 77 7. 160 11. 16

https://doi.org/10.1016/j.htct.2023.03.021

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Você pode enriquecer sua busca de uma forma muito simples. Use os índices de pesquisa combinados com os conectores (AND ou OR) e especifique cada vez mais sua busca.

Por exemplo, se você deseja buscar artigos sobre
casos de dengue no Brasil em 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

Veja abaixo a lista completa de índices de pesquisa que podem ser usados:

Cód. do Índice	Elemento
ti	título do artigo
au	autor
kw	palavras-chave do artigo
subject	assunto (palavras do título, resumo e palavras-chave)
ab	resumo
ta	título abreviado da revista (ex. Cad. Saúde Pública)
journal_title	título completo da revista (ex. Cadernos de Saúde Pública)
la	código do idioma da publicação (ex. pt - Português, es - Espanhol)
type	tipo do documento
pid	identificador da publicação
publication_year	ano de publicação do artigo
sponsor	financiador
aff_country	código do país de afiliação do autor
aff_institution	instituição de afiliação do autor
volume	volume do artigo
issue	número do artigo
elocation	elocation
doi	número DOI
issn	ISSN da revista
in	código da coleção SciELO (ex. scl - Brasil, col - Colômbia)
use_license	código da licença de uso do artigo

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Email: scielo@scielo.org

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