RESUMO Objetivo Verificar a relação entre o handicap auditivo e fragilidade em idosos residentes da comunidade. Método Estudo transversal realizado com 238 idosos (idade ≥ 60 anos), no ano de 2018. O questionário Hearing Handicap Inventory for the Elderly - Screening version - HHIE-S, foi aplicado para quantificar o handicap auditivo. A fragilidade foi avaliada segundo o Fenótipo de Fragilidade proposto por Fried e colaboradores, utilizando os 5 critérios: perda de peso não intencional, fadiga relatada, redução da força de preensão, redução da velocidade de caminhada e baixa atividade física. A relação entre o handicap auditivo e a fragilidade foi realizada por meio dos Testes Kruskal-Wallis e Spermann. Resultados Maior percepção do handicap auditivo foi verificado nos indivíduos pré-frágeis e frágeis, comparados aos não frágeis. O handicap auditivo apresentou correlação positiva e estatisticamente significante com maiores níveis de fragilidade. Conclusão O handicap auditivo está relacionado a fragilidade em idosos da comunidade.

ABSTRACT Purpose To verify the relationship between hearing handicap and frailty in community-dwelling older adults. Methods A cross-sectional study was carried out with 238 older adults (aged ≥ 60 years) in 2018. The Hearing Handicap Inventory for the Elderly – Screening version – HHIE-S was applied to assess the hearing handicap. To assess frailty, the Frailty Phenotype proposed for Fried and co-workers was adopted, objectively evaluating 5 criteria: unintentional weight loss, reported fatigue, reduced grip strength, reduced walking speed and low physical activity. It was investigated whether the hearing handicap were related with frailty using Kruskal-Wallis and Spearman test. Results Worse perception of the hearing handicap was found in pre-frail and frail individuals, compared to non-frail individuals. In addition, hearing handicap showed a positive and statistically significant correlation with frailty. Conclusion Hearing handicap is related to frailty in community-dwelling older adults.

RESUMO Objetivo: Identificar fatores associados a sintomas depressivos em idosos inseridos em contexto de alta vulnerabilidade social. Métodos: Estudo transversal realizado com 302 idosos de comunidade cadastrados em Unidades de Saúde da Família. Utilizou-se questionário sociodemográfico, Escala de Depressão Geriátrica, Mini Avaliação Nutricional, Questionário de Qualidade de Vida Short-Form-6D e Escala de Medical Outcome Study. Para análise de dados foi realizada regressão logística, considerando dois grupos, com e sem sintomas depressivos. Resultados: Uma boa percepção da qualidade de vida (OR: 0,21) e receber apoio emocional (OR: 0,98) se apresentaram enquanto fatores protetores à depressão; e ter riscos de desnutrição (OR: 4,87), pertencer ao sexo feminino (OR: 1,88) e morar só (OR: 2,34) indicaram fator preditor para a depressão. Conclusão: Qualidade de vida e suporte social foram identificados como fatores protetores para sintomas depressivos, enquanto estar sob risco de desnutrição, morar sozinho, relatar dor e ser do sexo feminino são fatores preditores.

ABSTRACT Objective: To identify factors associated with depressive symptoms in the elderly inserted in a context of high social vulnerability. Methods: A cross-sectional study was carried out with 302 elderly people enrolled in Primary Care. We used a sociodemographic questionnaire, Geriatric Depression Scale, Mini Nutritional Assessment, Shor-form-6D Quality of Life Questionnaire and Medical Outcome Study Scale. For data analysis, a logistic regression was performed considering two groups, with and without depressive symptoms. Results: A good perception of the quality of life (OR: 0.21) and receiving emotional support (OR: 0.98) were presented as protective factors for depression, have risks of malnutrition (OR: 4.87), belong to the female sex OR: 1.88) and living alone (OR: 2.34), indicated a predictor factor for depression. Conclusion: Quality of life and social support were identified as protective factors for depressive symptoms while being at risk of malnutrition, living alone, reporting pain and being female are predictors.

RESUMEN Objetivo: Identificar factores asociados a los síntomas depresivos en ancianos insertados en contexto de alta vulnerabilidad social. Métodos: Estudio transversal realizado con 302 ancianos de comunidad registrados en Unidades de Salud de la Familia. Se utilizó cuestionario sociodemográfico, Escala de Depresión Geriátrica, Mini Evaluación Nutricional, Cuestionario de Calidad de Vida Shor-form-6D y Escala de Medical Outcome Study. Para el análisis de datos ha sido realizada regresión logística considerando dos equipos, con y sin síntomas depresivos. Resultados: Una buena percepción de la calidad de vida (OR: 0,21) y recibir apoyo emocional (OR: 0,98) se presentaron como factores protectores a la depresión, tener riesgos de desnutrición (OR: 4,87), pertenecer al sexo femenino (OR: 4,87) OR: 1,88) y vivir solo (OR: 2,34), indicaron factor indicador para la depresión. Conclusión: La calidad de vida y el apoyo social han sido identificados como factores protectores para los síntomas depresivos en cuanto estar bajo el riesgo de desnutrición, vivir solo, relatar el dolor y ser del sexo femenino son factores indicadores

ABSTRACT Objective: To identify factors associated with depressive symptoms in the elderly inserted in a context of high social vulnerability. Methods: A cross-sectional study was carried out with 302 elderly people enrolled in Primary Care. We used a sociodemographic questionnaire, Geriatric Depression Scale, Mini Nutritional Assessment, Shor-form-6D Quality of Life Questionnaire and Medical Outcome Study Scale. For data analysis, a logistic regression was performed considering two groups, with and without depressive symptoms. Results: A good perception of the quality of life (OR: 0.21) and receiving emotional support (OR: 0.98) were presented as protective factors for depression, have risks of malnutrition (OR: 4.87), belong to the female sex OR: 1.88) and living alone (OR: 2.34), indicated a predictor factor for depression. Conclusion: Quality of life and social support were identified as protective factors for depressive symptoms while being at risk of malnutrition, living alone, reporting pain and being female are predictors.

RESUMEN Objetivo: Identificar factores asociados a los síntomas depresivos en ancianos insertados en contexto de alta vulnerabilidad social. Métodos: Estudio transversal realizado con 302 ancianos de comunidad registrados en Unidades de Salud de la Familia. Se utilizó cuestionario sociodemográfico, Escala de Depresión Geriátrica, Mini Evaluación Nutricional, Cuestionario de Calidad de Vida Shor-form-6D y Escala de Medical Outcome Study. Para el análisis de datos ha sido realizada regresión logística considerando dos equipos, con y sin síntomas depresivos. Resultados: Una buena percepción de la calidad de vida (OR: 0,21) y recibir apoyo emocional (OR: 0,98) se presentaron como factores protectores a la depresión, tener riesgos de desnutrición (OR: 4,87), pertenecer al sexo femenino (OR: 4,87) OR: 1,88) y vivir solo (OR: 2,34), indicaron factor indicador para la depresión. Conclusión: La calidad de vida y el apoyo social han sido identificados como factores protectores para los síntomas depresivos en cuanto estar bajo el riesgo de desnutrición, vivir solo, relatar el dolor y ser del sexo femenino son factores indicadores

RESUMO Objetivo: Identificar fatores associados a sintomas depressivos em idosos inseridos em contexto de alta vulnerabilidade social. Métodos: Estudo transversal realizado com 302 idosos de comunidade cadastrados em Unidades de Saúde da Família. Utilizou-se questionário sociodemográfico, Escala de Depressão Geriátrica, Mini Avaliação Nutricional, Questionário de Qualidade de Vida Short-Form-6D e Escala de Medical Outcome Study. Para análise de dados foi realizada regressão logística, considerando dois grupos, com e sem sintomas depressivos. Resultados: Uma boa percepção da qualidade de vida (OR: 0,21) e receber apoio emocional (OR: 0,98) se apresentaram enquanto fatores protetores à depressão; e ter riscos de desnutrição (OR: 4,87), pertencer ao sexo feminino (OR: 1,88) e morar só (OR: 2,34) indicaram fator preditor para a depressão. Conclusão: Qualidade de vida e suporte social foram identificados como fatores protetores para sintomas depressivos, enquanto estar sob risco de desnutrição, morar sozinho, relatar dor e ser do sexo feminino são fatores preditores.

PURPOSE: To investigate the changes induced by DisBa-01 on repair of wound healing after induced incisional hernia (IH) in rats. METHODS: Thirty two male albino rats were submitted to IH and divided into four experimental groups: G1, placebo control; G2, DisBa-01-treated; G3, anti-αvβ3 antibodies-treated and G4, anti-α2 antibodies-treated. Histological, biochemical and extracellular matrix remodeling analysis of abdominal wall were evaluated. RESULTS: After 14 days, 100% of the G2 did not present hernia, and the hernia ring was closed by a thin membrane. In contrast, all groups maintained incisional hernia. DisBa-01 also increased the number macrophages and fibroblasts and induced the formation of new vessels. Additionally, MMP-2 was strongly activated only in G2 (p<0.05). Anti- αvβ3-integrin antibodies produced similar results than DisBa-01 but not anti-α2 integrin blocking antibodies. CONCLUSION: DisBa-01 has an important role in the control of wound healing and the blocking of this integrin may be an interesting therapeutically strategy in incisional hernia.

PURPOSE: Incisional hernia (IH) is characterized by defective wound healing process. Disba-01, a αvb3 integrin blocker has shown to control the rate of wound repair and therefore it could be a target for new wound healing therapies.The objective of the study was to determine the changes induced by Disba-01 on repair of wound healing after induced IH in rats. METHODS: Thirty two male albino rats were submitted to IH and divided into 4 experimental groups: G1, placebo control; G2, DisBa-01-treated; G3, anti-αvβ3 antibodies-treated and G4, anti-α2 antibodies-treated. Histological. biochemical and extracellular matrix remodeling analysis of abdominal wall were evaluated. RESULTS: After 14 days, 100% of the G2 did not present hernia, and the hernia ring was closed by a thin membrane. In contrast, all groups maintained incisional hernia. DisBa-01 also increased the number macrophages and fibroblasts and induced the formation of new vessels. Additionally, MMP-2 was strongly activated only in G2 (P<0.05). Anti- αvβ3-integrin antibodies produced similar results than Disba-01 but not anti-α2 integrin blocking antibodies. CONCLUSION: These results strongly indicate that Disba-01 has an important role in the control of wound healing and the blocking of this integrin may be an interesting therapeutical strategy in IH.