ABSTRACT Campomanesia adamantium (Cambess.) O. Berg (guavira) is a native plant of the Cerrado and Pantanal, which has several medicinal activities and fruits with a unique flavor rich in vitamin C. The species does not have defined cultivation methods, requiring studies to increase biomass production. An alternative is the use of organic residues that can influence the chemical, physical and biological characteristics of soils and consequently increase plant production. Thus, the objective was to evaluate the effect of different organic residues and bokashi, on the biomass production of plants and on the levels of phenols, flavonoids and antioxidant activity of tea from the leaves of guavira. Five substrates were studied in pots and protected environment: soil; soil + rice husk chicken manure; soil + sawdust chicken manure; soil + castor bean cake; soil + Organosuper® with or without the use of Bokashi in a 5x2 factorial scheme, in a randomized block experimental design. It was observed that the rice husk chicken manure can be used to increase the initial growth and biomass production of guavira keeping the leaves antioxidant activity tea stable. The use of bokashi benefits the growth of guavira only when no other organic residue is added to soil. Cambess. Cambess (Cambess. O (guavira Pantanal C methods chemical Thus phenols environment cake Organosuper x 5x scheme design stable (Cambess

Abstract Objective: To evaluate autoimmune hepatitis (AIH) in a multicenter cohort of childhood-onset systemic lupus erythematosus (cSLE) patients. Methods: This retrospective multicenter study included 847 patients with cSLE, performed in 10 Pediatric Rheumatology services of São Paulo state, Brazil. AIH was defined according to the International Autoimmune Hepatitis Group criteria (IAHGC). The statistical analysis was performed using the Bonferroni's correction (p < 0.0033). Results: AIH in cSLE patients confirmed by biopsy was observed in 7/847 (0.8%) and all were diagnosed during adolescence. The majority occurred before or at cSLE diagnosis [5/7 (71%)]. Antinuclear antibodies were a universal finding, 43% had concomitantly anti-smooth muscle antibodies and all were seronegative for anti-liver kidney microsomal antibodies. All patients with follow-up ≥18 months (4/7) had complete response to therapy according to IAHGC. None had severe hepatic manifestations such as hepatic failure, portal hypertension and cirrhosis at presentation or follow-up. Further comparison of 7 cSLE patients with AIH and 28 without this complication with same disease duration [0 (0–8.5) vs. 0.12 (0–8.5) years, p = 0.06] revealed that the frequency of hepatomegaly was significantly higher in cSLE patients in the former group (71% vs. 11%, p = 0.003) with a similar median SLEDAI-2 K score [6 (0–26) vs. 7 (0–41), p = 0.755]. No differences were evidenced regarding constitutional involvement, splenomegaly, serositis, musculoskeletal, neuropsychiatric and renal involvements, and treatments in cSLE patients with and without AIH (p > 0.0033). Conclusions: Overlap of AIH and cSLE was rarely observed in this large multicenter study and hepatomegaly was the distinctive clinical feature of these patients. AIH occurred during adolescence, mainly at the first years of lupus and it was associated with mild liver manifestations.

OBJETIVO: A ossificação heterotópica (OH) é uma complicação da lesão medular traumática (LMT). Pode resultar em anquilose, prejudicando a reabilitação e a qualidade de vida. Estudos prévios não elucidaram a relação entre as potenciais variáveis independentes, propósito desse estudo. MÉTODO: De 230 pacientes com LMT, admitidos em 1998 no Hospital SARAH Brasília, 33 tiveram o diagnóstico de OH (14,4%; IC95% 10,1-19,6), que foram comparados a 33 controles. Os fatores de risco foram testados de forma bivariada e num modelo de regressão logística. RESULTADOS: Espasticidade (razão de chances 3,8; IC95% 1,15-12,30), número de escaras (2,1; 1,08-3,89) e tempo de lesão (1,1; 1,02-1,24) encontraram-se associadas, de forma independente, à presença de OH. Havia um efeito confundidor entre essas variáveis, porém sem interação. CONCLUSÃO: Espasticidade, escaras e tempo de lesão estão associados à OH na lesão medular traumática. Os dois primeiros são passíveis de prevenção e tratamento.

OBJECTIVE: Heterotopic ossification (HO) is a complication of the spinal cord injury (SCI). It can result in anchylosis, harming the rehabilitation and quality of life. Previous publications had not elucidated the relation between possible independent variables, the aim of this study. METHOD: From 230 patients with SCI, admitted in 1998 at Hospital SARAH Brasilia, 33 with HO (14.3%; CI95% 10.1-19.6) were compared with 33 controls. The risk factors had been tested in bivariate analysis and in a model of logistic regression. RESULTS: Spasticity (odds ratio=3.8; CI95% 1.15-12.30), number of pressure ulcers (2.1; CI95% 1.08-3.89) and time lapsed since the injury (1.1; CI95% 1.02-1.24) were independently associated with HO. There was a confounder effect among these variables, without interaction. CONCLUSION: Spasticity, pressure ulcer and time of injury are associated with HO in spinal cord injury. The first two factors can be prevented and treatable.