Los nuevos anticoagulantes orales son una alternativa más para el tratamiento y la prevencion de la enfermedad tromboembólica, como su farmacología es nueva, aquí presentamos una revisión de los aspectos farmacológicos más importantes desde su dosificación, variaciones de acuerdo con las diferentes características de los pacientes, hasta los protocolos recomendados para cirugía y para intercambio de diferentes anticoagulantes, también las ventajas y contraindicaciones, así como algunas recomendaciones de antídotos.

The new oral anticoagulants are an alternative for the treatment and prevention of thromboembolic disease, as its pharmacology is new, here is a review of the most important aspects from drug dosing and dose variations according to different patient, characteristics also present the recommended protocols for surgery and exchange of different anticoagulants benefits and contraindications as well as some recommendations of antidotes.

With the current knowledge of hypertension, the understanding of the pathophysiological mechanisms of hypertensionhas advanced, where the main actors are the renin angiotensin aldosterone system and the sympathetic system. However, we are still far from understanding the complex interplay of these compensatory mechanisms and the behavior of blood pressure. Today we know from various studies of hypertension, that 60 to 80% of the patients will require combined therapy for an adequate control of blood pressure numbers.