Pesquisa | SciELO

ABSTRACT Proper waste management is a major worldwide concern; waste is disposed of directly into the environment, affecting water, soil and air quality. The development and production of green energy sources is strongly encouraged in modern society. The aim of this study, in accordance with Sustainable Development Goals (SDGs) 1, 2 and 7 of the 2030 Agenda of the UN, is to combine the correct disposal of animal waste with the generation of energy to mitigate the energy insecurity of families in an extremely vulnerable semi-arid region in the north-east of the country using biodigesters. To this end, a conceptual proposal was drawn up for a low-cost, easy-to-maintain and easy-to-use biodigester. A small-scale prototype was used to assess its operation by evaluating the main factors that affect biogas production (pH, temperature and the biomass properties: total solids, fixed solids, volatile solids, concentration of volatile fatty acids and C/N ratio). Evaluation of the test prototype gave satisfactory results that corroborate other studies and make it possible to propose an economically viable and efficient full-scale biodigester for biogas production. concern environment water quality society study SDGs (SDGs 1 203 UN semiarid semi arid northeast north east biodigesters end lowcost, lowcost low cost, cost low-cost easytomaintain easy maintain easytouse use smallscale small scale pH, pH (pH properties solids CN C N ratio. ratio . ratio) fullscale full 20

https://doi.org/10.5935/1806-6690.20250023

Seasonality of the incidence of bronchiolitis in infants — Brazil, 2016–2022: An interrupted time-series analysis Brazil 2016–2022 20162022 2016 2022 timeseries time series 2016–202 2016202 201 202 2016–20 201620 20 2016–2 20162 2 2016–
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Friedrich, Frederico

; Lumertz, Magali Santos

; Petry, Lucas Montiel

; Pieta, Marina Puerari

; Bittencourt, Luana Braga

; Nunes, Bruno Brocker

; Garcia, Laura de Castro e

; Antunes, Marcos Otávio Brum

; Scotta, Marcelo Comerlato

; Stein, Renato Tetelbom

; Jones, Marcus Herbert

; Comaru, Talitha

; Pinto, Leonardo Araújo

Revista Paulista de Pediatria

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2025, Volume 43 elocation e2023203

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a sazonalidade da bronquiolite aguda no Brasil durante a temporada 2020–2022 e compará-la com a das temporadas anteriores. Métodos: Os dados de incidência de internações por bronquiolite aguda em lactentes <1 ano de idade foram obtidos do Departamento de Informática da base de dados da Saúde Pública Brasileira para o período entre 2016 e 2022. Esses dados também foram analisados por macrorregiões do Brasil (Norte, Nordeste, Sudeste, Sul e Centro-Oeste). Para descrever características sazonais e de tendência ao longo do tempo, utilizamos o Modelo de Médias Móveis Integradas Autorregressivas Sazonais. Resultados: Em comparação com o período pré-COVID-19, a incidência de hospitalizações relacionadas com bronquiolite aguda diminuiu 97% durante as intervenções não farmacológicas (março de 2020 – agosto de 2021), mas aumentou 95% após a flexibilização das intervenções não farmacológicas (setembro de 2021 – dezembro de 2022), resultando no aumento geral de 16%. Durante o período pré-COVID-19, as hospitalizações por bronquiolite aguda seguiram um padrão sazonal, que foi interrompido em 2020–2021, mas recuperaram-se em 2022, com um pico ocorrido em maio, aproximadamente 4% superior ao pico pré-COVID-19. Conclusões: Este estudo ressalta a influência significativa das intervenções contra a COVID-19 nas hospitalizações por bronquiolite aguda no Brasil. A restauração de um padrão sazonal em 2022 sublinha a interação entre as medidas de saúde pública e a dinâmica das doenças respiratórias em crianças pequenas. Objetivo 20202022 2020–202 comparála compará la anteriores Métodos 1 < 201 Norte, Norte (Norte Nordeste Sudeste CentroOeste. CentroOeste Centro Oeste . Centro-Oeste) tempo Sazonais Resultados préCOVID19, préCOVID19 préCOVID pré COVID 19, 19 pré-COVID-19 97 março 202 2021, , 2021) 95 setembro 2022) 16 16% 20202021 2020–2021 recuperaramse recuperaram se maio 4 préCOVID19. 19. Conclusões COVID19 COVID-1 pequenas 2020202 2020–20 20 Centro-Oeste préCOVID1 pré-COVID-1 9 COVID1 COVID- 202020 2020–2 2 pré-COVID- 20202 2020– pré-COVID

ABSTRACT Objective: To evaluate the seasonality of acute bronchiolitis in Brazil during the 2020–2022 season and compare it with the previous seasons. Methods: Data from the incidence of hospitalizations due to acute bronchiolitis in infants <1 year of age were obtained from the Department of Informatics of the Brazilian Public Health database for the period between 2016 and 2022. These data were also analyzed by macro-regions of Brazil (North, Northeast, Southeast, South, and Midwest). To describe seasonal and trend characteristics over time, we used the Seasonal Autoregressive Integrated Moving Averages Model. Results: Compared to the pre-COVID-19 period, the incidence of hospitalizations related to acute bronchiolitis decreased by 97% during non-pharmacological interventions (March 2020 – August 2021) but increased by 95% after non-pharmacological interventions relaxation (September 2021 – December 2022), resulting in a 16% overall increase. During the pre-COVID-19 period, hospitalizations for acute bronchiolitis followed a seasonal pattern, which was disrupted in 2020–2021 but recovered in 2022, with a peak occurring in May, approximately 4% higher than the pre-COVID-19 peak. Conclusions: This study underscores the significant influence of COVID-19 interventions on acute bronchiolitis hospitalizations in Brazil. The restoration of a seasonal pattern in 2022 highlights the interplay between public health measures and respiratory illness dynamics in young children. Objective 20202022 2020–202 seasons Methods 1 < 201 macroregions macro regions North, North (North Northeast Southeast South Midwest. Midwest . Midwest) time Model Results preCOVID19 preCOVID pre COVID 19 pre-COVID-1 97 nonpharmacological non pharmacological March 202 95 September , 2022) 16 increase 20202021 May 4 Conclusions COVID19 COVID-1 children 2020202 2020–20 20 preCOVID1 pre-COVID- 9 COVID1 COVID- 202020 2020–2 2 pre-COVID 20202 2020–

https://doi.org/10.1590/1984-0462/2025/43/2023203

[SciELO Preprints] - Risk of Adverse Health Outcomes in Patients with Poor Adherence to Cardiovascular Medication Treatment: a Systematic Review
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Malachias, Marcus Vinícius Bolívar Kaiser, Sergio Emanuel Albuquerque, Denilson Campos de Brandão, Andréa Araujo Sposito, Andrei C. Moura, Lidia Zytynski Magalhães, Lucélia Batista Neves Cunha Mota-Gomes, Marco Antonio Clausell, Nadine Jardim, Paulo César Veiga Nadruz, Wilson Barros, Bruno Monteiro Luna , Leonardo Castro Barroso, Weimar Kunz Sebba

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Data de publicação: 2024-09-16

Resumo: Pt En

Introdução: As doenças cardiovasculares (DCV) continuam a ser a principal causa de mortalidade em todo o mundo. A adesão ao tratamento medicamentoso é uma questão importante no manejo das DCV crônicas, influenciando diretamente os resultados e os custos com saúde. Objetivos: Esta revisão sistemática, apoiada pela Sociedade Brasileira de Cardiologia, avalia o impacto da baixa adesão aos medicamentos cardiovasculares em desfechos clínicos críticos, como morte e eventos cardiovasculares. Métodos: Foi realizada uma busca abrangente em quatro bases de dados, incluindo Medline, Embase, Lilacs e Cochrane Library. A revisão incluiu revisões sistemáticas com meta-análises que relataram estimativas de risco para a adesão aos medicamentos cardiovasculares. Foram selecionadas quatro revisões sistemáticas, cada uma incorporando estudos observacionais. Resultados: Os principais achados indicam que um aumento na adesão aos medicamentos reduz significativamente o risco de eventos cardiovasculares, acidente vascular cerebral (AVC) e morte por todas as causas. Especificamente, uma melhoria de 20% na adesão a medicamentos antihipertensivos, hipolipemiantes e outros medicamentos cardiovasculares correlacionou-se com reduções nos eventos cardiovasculares de 7%, 10% e 9%, respectivamente; AVC de 17%, 13% e 18%; e morte de 12%, 9% e 10%. A certeza das evidências foi moderada, sugerindo que esses efeitos provavelmente estão presentes. Esses achados enfatizam a importância de melhorar a adesão ao tratamento medicamentoso para aprimorar os resultados clínicos no manejo das DCV. Conclusões: As evidências demonstraram reduções em desfechos duros tanto na prevenção primária quanto secundária através do controle de condições como hipertensão e concentrações elevadas de colesterol LDL, bem como os benefícios da terapia antiplaquetária em doenças ateroscleróticas. No entanto, são necessários estudos adicionais para elucidar melhor a relação entre a adesão aos medicamentos cardiovasculares e a melhoria dos desfechos clínicos críticos.

Background: Cardiovascular diseases (CVD) remain the leading cause of mortality worldwide. Medication adherence is an important issue in managing chronic CVD, directly influencing outcomes and healthcare costs. Objectives: This systematic review, supported by the Brazilian Society of Cardiology, evaluates the impact of poor adherence to cardiovascular medications on critical clinical outcomes such as death and cardiovascular events. Methods: A comprehensive search was conducted across four databases, including Medline, Embase, Lilacs, and the Cochrane Library. The review included systematic reviews with meta-analyses that reported risk estimates for adherence to cardiovascular medications. Four systematic reviews, each incorporating observational studies, were selected. Results: The principal findings indicate that an increase in adherence to medications significantly reduces the risk of cardiovascular events, stroke, and all-cause death. Specifically, a 20% improvement in adherence to antihypertensive, lipid-lowering, and other cardiovascular medications correlated with reductions in cardiovascular events by 7%, 10%, and 9%, respectively; stroke by 17%, 13%, and 18%; and death by 12%, 9%, and 10%. The certainty of the evidence was moderate, suggesting that these effects are likely present. These findings emphasize the importance of enhancing medication adherence to improve clinical outcomes in CVD management. Conclusions: Evidence has demonstrated reductions in hard endpoints in both primary and secondary prevention through the control of conditions such as hypertension and elevated LDL cholesterol concentrations, as well as the benefits of antiplatelet therapy in atherosclerotic disease. However, additional studies are needed to better elucidate the relationship between adherence to cardiovascular medications and the improvement of critical clinical outcomes.

https://doi.org/10.1590/SciELOPreprints.9997

Genetic variability and selection of soybean genotypes under shading
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Evaristo, Anderson Barbosa

; Guimarães, Amanda Gonçalves

; Leite, João Paulo Ribeiro

; Rodrigues, Reimario de Castro

; Dobbss, Leonardo Barros

; Matsuo, Eder

; Santos, José Barbosa dos

Revista Ciência Agronômica

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2024, Volume 55 elocation e20228472

Resumo: En | Texto: En | PDF: En

ABSTRACT Shade-tolerant soybean genotypes will allow their greater adoption for use in agroforestry or intercropped systems in tropical and subtropical regions. These genotypes can be obtained from the selection of existing superior genotypes or through breeding programs. This study, was verified such genetic variability and select those genotypes with cultivation potential at reduced levels of photosynthetically active radiation (PAR). Morphophysiological and yield characteristics of 16 soybean genotypes were evaluated in two experiments conducted in a controlled environment and laid in a randomized block design with three replications. Genetic parameters, correlations and genetic diversity were estimated and path analysis was performed. The soybean cultivars used showed genetic variability with a high variation index and heritability, which is advantageous for the selection of superior cultivars. Leaf area showed genotypic correlation and had a direct effect on seed weight per plant, regardless of shading. Additionally, the number of pods, hypocotyl diameter, and leaf area, all indirectly contributed to seed weight per plant regardless of shading. Seven genotypes (NS7780, NS8338, NS7667, NS7901, RK8115, CZ37B43 and 8579RSF) were selected based on genetic gain obtained by the Mulamba and Mock index at the two levels of PAR reduction tested. Furthermore, five of these genotypes (CZ37B43, RK8115, NS7901, NS8338 and 8579RSF) were identified by the Unweighted Pair-Group method Arithmetic Mean, as suitable either as a shaded crop or, as parental materials in breeding programs. Shadetolerant Shade tolerant regions programs study PAR. . (PAR) 1 replications parameters performed heritability shading Additionally pods diameter NS7780, NS7780 NS (NS7780 NS7667 NS7901 RK8115 RK CZB CZ B CZ37B4 8579RSF RSF tested Furthermore CZ37B43, (CZ37B43 NS833 PairGroup Pair Group Mean (PAR NS778 (NS778 NS766 NS790 RK811 CZ37B (CZ37B4 NS83 NS77 (NS77 NS76 NS79 RK81 (CZ37B NS8 NS7 (NS7 RK8 (NS

https://doi.org/10.5935/1806-6690.20240009

Community and species-specific responses of coastal birds to COVID-19 “anthropause” in the largest hypersaline lagoon of South America speciesspecific species specific COVID19 COVID 19 COVID-1 anthropause “anthropause COVID1 1 COVID-
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Rangel, Danilo Freitas

; Costa, Leonardo Lopes

; Castro, Ítalo de Braga

Ocean and Coastal Research

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2024, Volume 72 elocation e24009

Resumo: En | Texto: En | PDF: En

Abstract The COVID-19 pandemic led to a reduction in human mobility, known as “anthropause.” Few studies have compared birds’ community patterns between lockdown and “new normal” periods, especially in extremophile environments. This study presents the first baseline by monitoring coastal birds on 10 beaches along the largest hypersaline lagoon in South America. The birds were counted in September and October 2021 (during a lockdown period) and in October 2022 (after the lockdown – “new normal”) during the morning. The continuous route transect methodology was applied by the same observer in all beaches. The Analysis of Covariance (ANCOVA) was used to investigate the response of community abundance to urbanization (raster-based variable) and time of COVID-19 pandemic (lockdown vs. new normal). Rarefaction curve and Permutational Analysis of Variance (PERMANOVA) were used to compare community richness and composition, respectively, between lockdown and new normal periods. Generalized Linear Models (GLM) with negative binomial distribution were applied to test the effect of the same predictors on the three more abundant species. The bird community structure and composition did not change when comparing lockdown and new normal periods, mainly due to dominance of synanthropic species. Among species-specific responses to lockdown, the Southern Lapwing Vanellus chilensis was more abundant during the lockdown on six of the nine beaches where it occurred. Oppositely, the Kelp Gull Larus dominicanus and the Neotropic Cormorant Nannopterum brasilianus were more abundant in new normal period, reinforcing that these species benefit from human subsidies. This may provide a unique opportunity for science-based sustainable ecotourism activities in urban areas with synanthropic species, capitalizing activities such as birdwatching, that would certainly contribute to environmental education actions. COVID19 COVID 19 COVID-1 mobility anthropause. anthropause “anthropause. periods environments 1 America 202 period after morning ANCOVA (ANCOVA rasterbased raster based variable vs normal. . normal) PERMANOVA (PERMANOVA respectively GLM (GLM speciesspecific specific occurred Oppositely subsidies sciencebased science birdwatching actions COVID1 COVID- “anthropause 20 2

https://doi.org/10.1590/2675-2824072.23085

Malformações arteriovenosas pulmonares na síndrome de Rendu-Osler-Weber RenduOslerWeber Rendu Osler Weber
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Araújo-Gomes, Cristiane Ferreira de

; Virgini-Magalhães, Carlos Eduardo

; Castro, Leonardo Silveira de

; Rodrigues Neto, Eduardo de Oliveira

; Bezerra, Alex Antunes

; Mayall, Monica Rochedo

; Riguetti-Pinto, Cristina Ribeiro

; Fagundes, Felipe Borges

Jornal Vascular Brasileiro

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2024, Volume 23 elocation e20230133

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Rendu-Osler-Weber syndrome, also known as hereditary hemorrhagic telangiectasia, is an autosomal dominant hereditary disorder. It is characterized by presence of multiple arteriovenous malformations (AVMs) and telangiectasias. This article reports two cases of patients with Rendu-Osler-Weber syndrome who had pulmonary AVMs and underwent successful endovascular treatment. A brief review of the literature shows that up to 50% of patients with the syndrome have pulmonary AVMs and there is usually a positive family history in these patients. These pulmonary AVMs are multiple in 30% of cases and are associated with the most severe disease complications. Most patients are asymptomatic, even in the presence of AVMs with right-left shunts. When these shunts exceed 25% of the total blood volume, dyspnea, cyanosis, digital clubbing, and extracardiac murmurs may occur. Endovascular treatment is safe and offers control of complications from hereditary hemorrhagic telangiectasia and is currently the treatment of choice for these lesions. RenduOslerWeber Rendu Osler Weber disorder (AVMs telangiectasias 50 30 asymptomatic rightleft right left 25 volume dyspnea cyanosis clubbing occur lesions 5 3 2

Resumo A síndrome de Rendu-Osler-Weber, também conhecida como telangiectasia hemorrágica hereditária, é uma doença hereditária autossômica dominante. Ela é caracterizada pela presença de múltiplas malformações arteriovenosas e telangiectasias. Este artigo relata dois casos de pacientes com síndrome de Rendu-Osler-Weber que apresentaram malformações arteriovenosas pulmonares e foram submetidos a tratamento endovascular com sucesso. Uma breve revisão da literatura mostra que até 50% dos pacientes com a síndrome têm malformações arteriovenosas pulmonares e geralmente há um histórico familiar positivo nesses pacientes. Em 30% dos casos, elas são múltiplas e estão associadas a complicações mais graves da doença. A maioria dos pacientes é assintomática, mesmo na presença de malformações arteriovenosas com shunt direito-esquerdo. Quando esses shunts excedem 25% do volume total de sangue, podem surgir dispneia, cianose, baqueteamento digital e sopros extracardíacos. O tratamento endovascular oferece segurança e controle das complicações da telangiectasia hemorrágica hereditária, sendo atualmente o tratamento de escolha para essas lesões. RenduOslerWeber, RenduOslerWeber Rendu Osler Weber, Weber dominante telangiectasias sucesso 50 30 assintomática direitoesquerdo. direitoesquerdo direito esquerdo. esquerdo direito-esquerdo 25 sangue dispneia cianose extracardíacos lesões 5 3 2

https://doi.org/10.1590/1677-5449.202301331

Bayesian inference applied to soybean grown under different shading levels using the multiple-trait model multipletrait multiple trait
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Silva Júnior, Antônio Carlos da

; Costa, Weverton Gomes da

; Guimarães, Amanda Gonçalves

; Moura, Waldênia de Melo

; Campos, Leonardo José Motta

; Rodrigues, Reimário de Castro

; Bhering, Leonardo Lopes

; Cruz, Cosme Damião

; Evaristo, Anderson Barbosa

Scientia Agricola

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2024, Volume 81 elocation e20220233

Resumo: En | Texto: En | PDF: En

ABSTRACT present study aimed to determine the effects of different light restriction levels (shading levels) on soybean genetic parameters using a Bayesian multi-trait model (MTM) and select high-yielding soybean cultivars. Eighteen commercial soybean cultivars bred in a soybean breeding program were evaluated over two agricultural seasons. Three shading levels were used over two agricultural crop seasons, giving six treatments (light restriction × crop season). The experiments were arranged in a randomized complete block design with six treatments replicated thrice. The genetic values and parameters were estimated using a Monte Carlo Markov Chain algorithm. Broad-sense heritability range from 0.2093 to 0.7153. The lowest genotypic variance estimate was observed at the 45 % photosynthetically active radiation level in the 2019/2020 crop season year compared with that of other shading levels. Furthermore, a 40 % selection intensity had the highest soybean yield under different shading levels. The Bayesian MTM combined with the factor analysis and genotype-ideotype distance method can be used to evaluate and select soybean genotypes considering different shading levels. The soybean cultivars 8579RSF, NS8338, NS7901, NS7667, RK8115, and 8473RSF had higher genetic potential than other cultivars under different shading levels. multitrait multi trait (MTM highyielding high yielding seasons season. . season) thrice algorithm Broadsense Broad sense 02093 0 2093 0.209 07153 7153 0.7153 4 20192020 2019 2020 2019/202 Furthermore genotypeideotype genotype ideotype 8579RSF RSF NS8338 NS NS7901 NS7667 RK8115 RK 0209 209 0.20 0715 715 0.715 2019202 201 202 2019/20 NS833 NS790 NS766 RK811 020 20 0.2 071 71 0.71 201920 2019/2 NS83 NS79 NS76 RK81 02 2 0. 07 7 0.7 20192 2019/ NS8 NS7 RK8

https://doi.org/10.1590/1678-992x-2022-0233

Diagnosis and treatment of asthma in childhood: an overview of guidelines childhood
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Furukawa, Laissa Harumi

; Garcia, Laura de Castro e

; Pieta, Marina Puerari

; Castro, Miguel Ângelo de

; Pinto, Leonardo Araújo

; Pitrez, Paulo M

Jornal Brasileiro de Pneumologia

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2024, Volume 50 Nº 1 elocation e20240051

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36416/1806-3756/e20240051

Plasma Electrolytic Nitrocarburizing of SAE 1045: Electro-chemical Slurry Erosion Wear Analysis 1045 Electrochemical Electro chemical 104 10 1
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Noronha, Leandro Câmara

; Castro, Victor Velho de

; Schroeder, Roberto Moreira

; Mussulini, Leonardo

; Santos, Leonardo Moreira dos

; Andrade, Antonio Marcos Helgueira de

; Malfatti, Célia de Fraga

Materials Research

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2024, Volume 27 elocation e20230283

Resumo: En | Texto: En | PDF: En

Nitrocarburized coating by plasma electrolytic saturation, PEN/C coatings, have been proposed to increase the corrosion and wear resistance of steel by using a process of low-temperature hydrostatic plasma. The objective of this work is to analyse the wear and corrosion resistance of PEN/C coatings on SAE 1045 steel, using the electrochemical slurry erosion wear test (ESEWT). This test allows the evaluation of the simultaneous effect of erosion wear and electrochemical behaviour on this coating. Thus, it was possible to evaluate the erosive and corrosive effect and the synergy of these phenomena on the PEN/C coated SAE 1045 mass loss rates. ESEWT tests were performed at different times and under different electrochemical conditions: under cathodic protection and open circuit potential (OCP). The PEN/C coating increased the corrosion resistance of SAE 1045. Synergy between the erosive wear and corrosion was the main factor in the mass loss rates of both analysed systems. The synergistic mechanism of the substrate occurred by removing the corrosion product and by activating the surface generated by the erosive process of the particles. The synergistic mechanism of the PEN/C coating occurred with the removal of inherent surface irregularities through the erosive process, combined with localized corrosion. saturation PENC PEN C lowtemperature low temperature 104 ESEWT. . (ESEWT) Thus conditions OCP. OCP (OCP) systems particles 10 (ESEWT (OCP 1

https://doi.org/10.1590/1980-5373-mr-2023-0283

10.

Diretriz Brasileira de Ergometria em População Adulta – 2024 202 20 2
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Carvalho, Tales de

; Freitas, Odilon Gariglio Alvarenga de

; Chalela, William Azem

; Hossri, Carlos Alberto Cordeiro

; Milani, Mauricio

; Buglia, Susimeire

; Precoma, Dalton Bertolim

; Falcão, Andréa Maria Gomes Marinho

; Mastrocola, Luiz Eduardo

; Castro, Iran

; Albuquerque, Pedro Ferreira de

; Coutinho, Ricardo Quental

; Brito, Fabio Sandoli de

; Alves, Josmar de Castro

; Serra, Salvador Manoel

; Santos, Mauro Augusto dos

; Colombo, Clea Simone Sabino de Souza

; Stein, Ricardo

; Herdy, Artur Haddad

; Silveira, Anderson Donelli da

; Castro, Claudia Lucia Barros de

; Silva, Miguel Morita Fernandes da

; Meneghello, Romeu Sergio

; Ritt, Luiz Eduardo Fonteles

; Malafaia, Felipe Lopes

; Marinucci, Leonardo Filipe Benedeti

; Pena, José Luiz Barros

; Almeida, Antônio Eduardo Monteiro de

; Vieira, Marcelo Luiz Campos

; Stier Júnior, Arnaldo Laffitte

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 Nº 3 elocation e20240110

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20240110

11.

Prognostic value of programmed cell death ligand 1 (PD-L1) expression in patients with stage III non-small cell lung cancer under different treatment types: a retrospective study PDL1 PDL PD L1 L (PD-L1 nonsmall non small types (PD-L
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Castro, Nicoly Marques de

; Moura, Fernando

; Hada, Aline Lury

; Garcia, Diogo

; Victor, Elivane da Silva

; Schvartsman, Gustavo

; Carvalho, Leonardo

; Fernandes, Milena Lourenço Coleta

; Martins, Rodrigo de Souza

; Silva, Elaine Ferreira da

; Santos, Sarah Silva Mello Batista dos

; Taniwaki, Letícia

; Taranto, Patrícia

; Pontes, Janaina

; Beal, Juliana Rodrigues

; Dutra, Ana Carolina Pereira

; Oliveira Filho, João Bosco de

; Araujo, Sérgio Eduardo Alonso

; Usón Junior, Pedro Luiz Serrano

einstein (São Paulo)

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2024, Volume 22 elocation eAO0575

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective Currently programmed cell death protein 1 (PD-1) inhibitors in combination with other therapies are being evaluated to determine their efficacy in cancer treatment. However, the effect of PD-ligand (L) 1 expression on disease outcomes in stage III (EC III) non-small cell lung cancer is not completely understood. Therefore, this study aimed to assess the influence of PD-L1 expression on the outcomes of EC III non-small cell lung cancer. Methods This study was conducted on patients diagnosed with EC III non-small cell lung cancer who underwent treatment at a tertiary care hospital. PD-L1 expression was determined using immunohistochemical staining, all patients expressed PD-L1. Survival was estimated using the Kaplan-Meier method. Relationships between variables were assessed using Cox proportional regression models. Results A total of 49 patients (median age=69 years) with EC III non-small cell lung cancer and PD-L1 expression were evaluated. More than half of the patients were men, and most were regular smokers. The patients were treated with neoadjuvant chemotherapy, surgery, or sequential or combined chemotherapy and radiotherapy. The median progression-free survival of the entire cohort was 14.2 months, and the median overall survival was 20 months. There was no significant association between PD-L1 expression and disease progression, clinical characteristics, or overall survival. Conclusions PD-L1 expression was not correlated with EC III non-small cell lung cancer outcomes. Whether these findings differ from the association with immune checkpoint inhibitors remains to be addressed in future studies. PD1 PD (PD-1 However PDligand ligand L (L nonsmall non small understood Therefore PDL1 PDL L1 PD-L hospital staining PDL1. L1. KaplanMeier Kaplan Meier method models 4 age69 age 69 age=6 years men smokers surgery radiotherapy progressionfree progression free 142 14 2 14. months characteristics studies (PD- age6 6 age= (PD

https://doi.org/10.31744/einstein_journal/2024ao0575

12.

Expression of somatostatin receptors in hemangioblastomas associated with von Hippel-Lindau disease as a novel diagnostic, therapeutic, and follow-up opportunity: A case report and literature review HippelLindau Hippel Lindau diagnostic therapeutic followup follow up opportunity
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Brabo, Eloá Pereira

; Altino de Almeida, Sergio

; Rafful, Patrícia Piazza

; Rosado-de-Castro, Paulo Henrique

; Vieira Neto, Leonardo

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230181

Resumo: En | Texto: En | PDF: En

SUMMARY Hemangioblastomas associated with von Hippel-Lindau (VHL) disease are frequently multiple and recur during prolonged follow-up. Currently, no systemic treatment is available for these tumors. Recent studies have shown the expression of somatostatin receptors in these types of hemangioblastomas. Notably, increased somatostatin receptor expression in a tumor, as determined by peptide-receptor radionuclide imaging, is a predictive factor of response to treatment with somatostatin analogs and peptide-receptor radionuclide therapy. The aim of this study was to describe the case of a patient with increased expression of somatostatin receptors in a suprasellar hemangioblastoma associated with VHL disease and conduct a literature review on somatostatin receptor expression in patients with VHL-associated hemangioblastomas. We describe herein the case of a 51-year-old man with VHL disease who had a suprasellar hemangioblastoma detected on magnetic resonance imaging. Peptide-receptor radionuclide imaging using gallium-68-DOTATOC (68Ga-DOTATOC) identified increased expression of somatostatin receptors in the suprasellar hemangioblastoma, along with multiple pancreatic neuroendocrine tumors and bilateral pheochromocytomas. The patient was treated for 1 year with lanreotide, a somatostatin analog. A repeat 68Ga-DOTATOC 1 year after starting lanreotide revealed decreased radiotracer uptake by the hemangioblastoma, consistent with a metabolic response. The presence of somatostatin receptors in hemangioblastomas associated with VHL disease is a novel finding. The decreased expression of these receptors after treatment with a somatostatin analog, as described in the present case, positions the somatostatin receptor as a new target for novel diagnostic, therapeutic, and follow-up opportunities in patients with VHL disease. HippelLindau Hippel Lindau (VHL followup. followup follow up. up Currently Notably tumor peptidereceptor peptide therapy VHLassociated 51yearold yearold 51 old Peptidereceptor Peptide gallium68DOTATOC galliumDOTATOC gallium 68 DOTATOC 68GaDOTATOC GaDOTATOC 68Ga Ga (68Ga-DOTATOC pheochromocytomas analog finding diagnostic therapeutic 5 6

https://doi.org/10.20945/2359-4292-2023-0181

13.

Modelo de mapeamento semântico entre as terminologias de saúde CID-10 e SNOMED-CT CID10 CID 10 CID-1 SNOMEDCT SNOMED CT CID1 1 CID-
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Gualdani, Fabrício Amadeu

; Botega, Leonardo Castro

; Miranda, Nelson Júlio de Oliveira

; Ferreira, Allan

; Peres, Reinaldo Porte

Em Questão

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2024, Volume 30 elocation e-134988

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: A Classificação Estatística Internacional de Doenças e Problemas Relacionados à Saúde e a Nomenclatura Sistematizada de Medicina são terminologias que visam a transparência dos dados. Terminologias possuem diferenças em suas composições, sendo necessário um mapeamento entre esses termos para que um sentido possa ser obtido, aprimorando o cotidiano de profissionais da saúde com os seus pacientes por um modelo que estruture as informações de forma compreensiva de maneira sintática e semântica. O objetivo desta pesquisa é desenvolver um modelo para o mapeamento semântico entre estas terminologias de saúde. Trata-se de uma pesquisa exploratória, um estudo de caso realizado no Hospital das Clínicas da Faculdade de Medicina de Marília, que forneceu os códigos da Classificação Estatística Internacional de Doenças e Problemas Relacionados à Saúde registrados nos prontuários para a realização do mapeamento, visando migrar os dados armazenados que se encontravam em um banco de dados relacional para uma rede internacional de estrutura e compartilhamento de dados. Os resultados evidenciaram que há quatro tipos de situações durante a realização do mapeamento: exatidão semântica entre as terminologias, uso de expressões que tornam a condição de saúde genérica, termos que não são exatamente equivalentes, no entanto possuem aproximação semântica, assim como uma variedade de termos para representar uma única condição de saúde. Obedecendo este direcionamento, conclui-se que é possível desenvolver um modelo replicável que preserve a camada semântica dos termos entre a Classificação Estatística Internacional de Doenças e Problemas Relacionados à Saúde e a Nomenclatura Sistematizada de Medicina. Resumo composições obtido Tratase Trata exploratória Marília genérica equivalentes direcionamento concluise conclui

Abstract: The International Statistical Classification of Diseases and Health Problems and the Systematized Nomenclature of Medicine are terminologies that aim for data transparency. Terminologies have differences in their compositions, and a mapping between these terms is necessary in order to obtain meaning, seeking to improve the daily life of health professionals with their patients through a model that structures the information in a comprehensive syntactic and semantic way. The goal of this research is to develop a model for semantic mapping between these health terminologies. This is exploratory research, a case study carried out at the Hospital das Clínicas da Faculdade de Medicina de Marília, which provided the International Statistical Classification of Diseases and Health-Related Problems codes recorded in the medical records for the mapping, aiming to migrate the stored data that were in a relational database to an international structure and data sharing network. The results showed that there are four types of situations during the mapping process: semantic accuracy between terminologies, use of expressions that make the health condition generic, terms that are not exactly equivalent but are semantically close, and a variety of terms to represent a single health condition. It is concluded that it is possible to develop a replicable model that preserves the semantic layer of terms between the International Statistical Classification of Diseases and Health Problems and the Systematized Nomenclature of Medicine. Abstract transparency compositions meaning way Marília HealthRelated Related network process generic close

https://doi.org/10.1590/1808-5245.30.134988

14.

Diretrizes da Sociedade Brasileira de Cardiologia: Novas Normas, Novos Desafios Cardiologia Normas
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Polanczyk, Carisi A.

; Luna, Leonardo Castro

; Rey, Helena Cramer Veiga

; Moreira, Humberto Graner

; de Arruda, José Airton

; de Barros e Silva, Pedro Gabriel Melo

; de Seixas Rocha, Mario

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 Nº 6 elocation e20240258

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20240258

15.

Benzbromarone as adjuvant therapy for cystic fibrosis lung disease: a pilot clinical trial disease
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Friedrich, Frederico

; Petry, Lucas Montiel

; Garcia, Laura de Castro e

; Pieta, Marina Puerari

; Meneses, Amanda da Silva

; Bittencourt, Luana Braga

; Xavier, Luiza Fernandes

; Antunes, Marcos Otávio Brum

; Grun, Lucas Kich

; Lumertz, Magali

; Kunzelmann, Karl

; Pinto, Leonardo Araujo

Jornal Brasileiro de Pneumologia

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2024, Volume 50 Nº 3 elocation e20230292

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: Cystic fibrosis (CF) affects multiple organs, the most severe consequences being observed in the lungs. Despite significant progress in developing CF transmembrane conductance regulator-specific treatments for CF lung disease, exploring alternative CF-targeted medications seems reasonable. We sought to evaluate the potential beneficial effects of oral benzbromarone as an adjuvant therapy in CF patients with reduced lung function. Methods: This was a prospective open-label pilot study of oral benzbromarone (100 mg/day) administered once daily for 90 days. Patients were followed at a tertiary referral center in southern Brazil. Safety was assessed by the number of reported adverse events. Secondary objectives included percent predicted FEV1 (FEV1%) and pulmonary exacerbations. Results: Ten patients were enrolled. Benzbromarone was found to be safe, with no serious drug-related adverse events. Eight patients completed the study; the median relative change in FEV1% tended to increase during the treatment, showing an 8% increase from baseline at the final visit. However, a nonparametric test showed that the change was not significant (p = 0.06). Of a total of ten patients, only one experienced at least one pulmonary exacerbation during the study. Conclusions: Oral benzbromarone appears to be safe, and improved FEV1% has been observed in patients with CF. Further assessment in larger trials is warranted to elucidate whether oral benzbromarone can be a potential adjuvant therapy for CF. Objective (CF organs lungs regulatorspecific regulator specific disease CFtargeted targeted reasonable function Methods openlabel open label 100 (10 mg/day mgday mg day 9 days Brazil events FEV (FEV1% exacerbations Results enrolled safe drugrelated drug related treatment 8 visit However p 0.06. 006 0.06 . 0 06 0.06) Conclusions 10 (1 (FEV1 00 0.0 1 ( (FEV 0.

https://doi.org/10.36416/1806-3756/e20230292

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