ABSTRACT Purpose: This study aimed to determine whether early-stage intraocular pressure can be modulated using a thermal face mask. Methods: In this prospective clinical study, healthy participants were randomized on a 1:1:1 allocation ratio to three mask groups: hypothermic (G1), normothermic (G2), and hyperthermic (G3). After randomization, 108 eyes from 108 participants were submitted to clinical evaluations, including measurement of initial intraocular pressure (T1). The thermal mask was then applied for 10 minutes, followed by a second evaluation of intraocular pressure (T2) and assessment of any side effects. Results: The hypothermic group (G1) showed a significant reduction in mean intraocular pressure between T1 (16.97 ± 2.59 mmHg) and T2 (14.97 ± 2.44 mmHg) (p<0.001). G2 showed no significant pressure difference between T1 (16.50 ± 2.55 mmHg) and T2 (17.00 ± 2.29 mmHg) (p=0.054). G3 showed a significant increase in pressure from T1 (16.53 ± 2.69 mmHg) to T2 (18.58 ± 2.95 mmHg) (p<0.001). At T1, there was no difference between the three study groups (p=0.823), but at T2, the mean values of G3 were significantly higher than those of G1 and G2 (p<0.00). Conclusion: Temperature was shown to significantly modify intraocular pressure. Thermal masks allow the application of temperature in a controlled, reproducible manner. Further studies are needed to assess the duration of these effects and whether they are reproducible in patients with pathologies that affect intraocular pressure. Purpose earlystage early stage Methods 111 1 1:1: G1, G , G2, (G2) G3. . (G3) randomization evaluations T1. T (T1) minutes (T2 Results (G1 16.97 1697 16 97 (16.9 259 2 59 2.5 mmHg 14.97 1497 14 (14.9 244 44 2.4 p<0.001. p0001 p p<0.001 0 001 (p<0.001) 16.50 1650 50 (16.5 255 55 17.00 1700 17 00 (17.0 229 29 2.2 p=0.054. p0054 p=0.054 054 (p=0.054) 16.53 1653 53 269 69 2.6 18.58 1858 18 58 (18.5 295 95 2.9 p=0.823, p0823 p=0.823 823 (p=0.823) p<0.00. p000 p<0.00 (p<0.00) Conclusion controlled manner 11 1:1 (G2 (G3 (T1 (T (G 16.9 169 9 (16. 25 5 2. 14.9 149 (14. 24 4 (p<0.001 16.5 165 17.0 170 (17. 22 p005 p=0.05 05 (p=0.054 26 6 18.5 185 (18. p082 p=0.82 82 (p=0.823 p00 p<0.0 (p<0.00 1: 16. (16 14. (14 17. (17 p=0.0 (p=0.05 18. (18 p08 p=0.8 8 (p=0.82 p0 p<0. (p<0.0 (1 p=0. (p=0.0 (p=0.8 p<0 (p<0. ( p=0 (p=0. p< (p<0 p= (p=0 (p< (p= (p

RESUMEN El apoyo social es una dimensión esencial para romper las dificultades de participación social de los estudiantes con discapacidad. El objetivo del presente estudio fue conocer la perspectiva de estudiantes con incapacidad auditiva, visual, física o motora y dificultades específicas de aprendizaje sobre lo que consideran suporte social. Con este fin, se desenrolló un estudio cualitativo con 15 estudiantes de 3.º a 12.º grado (8 a 18 años de edad). Las entrevistas semiestructuradas fueron analizadas a partir de categorías previamente definidas; de los datos surgieron subcategorías. Los estudiantes valoraron la disponibilidad de sus compañeros y maestros para apoyarlos e involucrarlos en las actividades de clase y la expresión de empatía y cuidado. También se refirieron a situaciones de rechazo y exclusión. El artículo discute condiciones que favorecen el conocimiento del otro y una cultura de suporte social recíproco, esencial para facilitar la participación social.

ABSTRACT Social support is essential for overcoming the difficulties that students with special educational needs face in interacting with peers. The goal of the study was to explore the perspective of students presenting with hearing, visual and physical or motor deficiencies and specific learning difficulties about what they consider to be social support. To this end, we developed a qualitative study. Semi-structured interviews were conducted with 15 students (3rd to the 12th grade; 8 to 18 years old). Answers were analyzed from previously defined categories, subcategories emerged from the data. Students valued the availability of their classmates and teachers to support and involve them in class activities, as well as expressions of empathy, care and attention. Students mentioned situations of rejection and exclusion. The paper discusses conditions that favor mutual knowledge and a culture of reciprocal social support, both of which are essential to facilitate students’ social participation.

RESUMO O suporte social permite quebrar dificuldades de participação social de alunos com necessidades educativas específicas. O objetivo do estudo foi conhecer a perspetiva de alunos com deficiência auditiva, visual, físico-motora e dificuldades específicas de aprendizagem sobre o que consideram ser suporte social. Para tal, foi desenvolvido um estudo de natureza qualitativa. Foram realizadas entrevistas semiestruturadas a 15 alunos com estas condições (do 3.º ao 12.º, com idades entre os 8 e 18 anos). As respostas foram analisadas a partir de categorias previamente definidas, tendo emergido um conjunto de subcategorias a partir dos dados. Os alunos valorizaram a disponibilidade dos seus colegas e professores para os apoiar e os envolver nas atividades da turma e a expressão de empatia e cuidado. Referiram também situações de rejeição e exclusão. No artigo são discutidas condições que favorecem o conhecimento do outro e uma cultura de suporte social recíproco, essenciais para a participação social.

Abstract Medical communication skills are treated as innate abilities, without the need for training and evaluation. However, they play a very important role in the doctor-patient relationship. Communication deficits are a cause of dissatisfaction and litigation. Quality communication is associated with greater adherence to proposed procedures and increases patient satisfaction and safety. Effective communication is particularly important in Gynecology-Obstetrics and justifies specific training. Formal teaching of communication skills should be included at all levels of medical education, just like technical-scientific skills.

Resumo As capacidades comunicacionais dos médicos são tratadas como habilidades inatas, sem a necessidade de treino e avaliação. Desempenham, no entanto, um papel da maior importância na relação médico-doente. Os déficits de comunicação são causa de descontentamento e motivo de litigância. A comunicação de qualidade está associada a maior adesão aos procedimentos propostos, aumenta a satisfação e segurança do doente. A comunicação eficaz assume particular acutilância em Ginecologia-Obstetrícia e justifica que seja objeto de treino específico. O ensino formal da competência em comunicação deve ser incluído em todos os níveis da educação médica, à semelhança das competências técnico-científicas.

Abstract Objective Complex regional pain syndrome (CRPS) requires further understanding. Thus, the present study aimed to analyze if pre- and intraoperative factors may be related to the development of CRPS in the postoperative period. Methods We reviewed 1,183 medical records of patients undergoing forearm and hand surgeries from 2015 to 2021. The data of interest, that is, diagnosis, incisions, synthesis material, and anesthesia, were collected, tabulated, and statistically analyzed, with subsequent calculation of the odds ratios. Results Most patients were female, aged between 30 and 59 years, and sought the service electively (67% of the cases). The diagnoses included soft tissue trauma (43%), bone trauma (31.6%), and compressive syndromes (25.5%). During this period, 45 (3.8%) subjects developed CRPS. The statistical analysis showed that the chance of developing CRPS is twice as high in patients with compressive syndrome, especially carpal tunnel syndrome (CTS), which represented most surgeries performed in our service (24%). Two or more incisions occurred in 7.6% of the cases, which tripled the chance of developing postoperative CRPS. Gender, age, use pf synthetic material, type of anesthesia type did not statistically increase the risk of developing postoperative CRPS. Conclusion In short, the incidence of CRPS is low; however, it is critical to know and recognize the risk factors for prevention and active screening in the postoperative period. (CRPS understanding Thus pre period 1183 1 183 1,18 201 2021 interest diagnosis material collected tabulated analyzed ratios female 3 5 years 67% 67 (67 cases. cases . cases) 43%, 43 43% , (43%) 31.6%, 316 31.6% 31 6 (31.6%) 25.5%. 255 25.5% 25 (25.5%) 4 3.8% 38 8 (3.8% CTS, CTS (CTS) 24%. 24 24% (24%) 76 7 7.6 Gender age short low however 118 18 1,1 20 202 (6 (43% 31.6 (31.6% 25.5 2 (25.5% 3.8 (3.8 (CTS (24% 7. 11 1, ( (43 31. (31.6 25. (25.5 3. (3. (24 (4 (31. (25. (3 (2 (31 (25

Resumo Objetivo A síndrome da dor regional complexa (SDRC) precisa ser mais bem compreendida. Assim, este estudo objetiva analisar se fatores pré e intraoperatórios poderiam estar relacionados ao desenvolvimento de SDRC no pós-operatório. Métodos Foram revisados 1.183 prontuários de pacientes submetidos a cirurgias no antebraço e na mão entre 2015 e 2021. Os dados de interesse, como diagnóstico, incisões, material de síntese e anestesia realizada, foram coletados, tabulados e submetidos a testes estatísticos com posterior cálculo da razão de chances. Resultados A maioria dos pacientes era do gênero feminino, com idade entre 30 e 59 anos, que buscaram o serviço de forma eletiva (67% dos casos). Os diagnósticos agrupados de forma geral foram: traumas de partes moles (43%), traumas ósseos (31,6%) e síndromes compressivas (25,5%). Durante esse período, 45 pacientes (3,8%) evoluíram com SDRC. A análise estatística mostrou que a chance de desenvolver SDRC é duas vezes maior em pacientes com síndrome compressiva, especialmente a síndrome do túnel do carpo (STC), que representou a maioria dos cirurgias realizadas em nosso serviço (24%). Em 7,6% dos casos, foram realizadas duas ou mais incisões, o que triplicou a possibilidade de SDRC pósoperatória. Gênero, idade, uso de material de síntese, ou tipo de anestesia não aumentaram estatisticamente o risco de SDRC no pós-operatório. Conclusão Em suma, a incidência de SDRC é baixa, mas é importante conhecer e reconhecer os fatores de risco para a prevenção e a busca ativa no pós-operatório. (SDRC compreendida Assim pósoperatório. pósoperatório pós operatório. operatório pós-operatório 1183 1 183 1.18 201 2021 interesse diagnóstico incisões realizada coletados chances feminino 3 5 anos 67% 67 (67 casos. casos . casos) 43%, 43 43% , (43%) 31,6% 316 31 6 (31,6% 25,5%. 255 25,5% 25 (25,5%) período 4 3,8% 38 8 (3,8% compressiva STC, STC (STC) 24%. 24 24% (24%) 76 7 7,6 pósoperatória Gênero suma baixa 118 18 1.1 20 202 (6 (43% 31,6 (31,6 25,5 2 (25,5% 3,8 (3,8 (STC (24% 7, 11 1. ( (43 31, (31, 25, (25,5 3, (3, (24 (4 (31 (25, (3 (2 (25

Abstract Objective To evaluate surgeons’ performance in resecting CAM-type deformities using a realistic arthroscopic surgery simulator. Methods An arthroscopic simulator was created using low-cost materials with the help of a GTMax Core A1 3D printer and the programs Invesalius and Meshmixer 2017, which were used to develop femoral head parts in ABS material, with the presence of a CAM-type deformity, to mimic a femoroacetabular impact situation. After the operations were performed by 16 surgeons, the femurs were compared to a previous model with deformity and another without, using Cloudcompare, and parameters such as the volumetric difference between the operated femurs, with and without deformity, the minimum and maximum distance between them, the percentage of the deformity resected, the estimated time for total resection of the deformity, as well as a qualitative analysis based on the images and graphs provided by the program representing the areas of the parts resected, were evaluated at the end. Results The average resection speed was 34.66 mm3/min (SD = 46 mm3/min, max = 147.33; min = −2.66). The average resection rate was 26.2% (SD = 34.7%, max = 111; min = −2). Qualitative analysis showed hyporesection of deformities and sometimes hyperresection of nondeformed areas. The simulator was highly rated by the surgeons, with a tactile sensation very similar to real surgery, according to them. Conclusion Arthroscopic simulators have proved very useful in training less experienced surgeons. surgeons CAMtype CAM type lowcost low cost A D 2017 material situation 1 Cloudcompare them resected end 3466 34 66 34.6 mm3min mmmin mm3 mm SD 4 147.33 14733 147 33 −2.66. 266 −2.66 . 2 −2.66) 262 26 26.2 347 7 34.7% 111 −2. −2 −2) 201 346 3 6 34. 147.3 1473 14 −2.6 26. 34.7 11 − 20 147.

Resumo Objetivo Avaliar o desempenho de cirurgiões na ressecção de deformidades tipo CAME fazendo uso de um simulador realista de cirurgia artroscópica. Métodos Um simulador artroscópico foi criado a partir de materiais de baixo custo com auxílio de uma impressora 3D GTMax Core A1 e dos programas Invesalius e Meshmixer 2017, que foram utilizados para criar peças de cabeça de fêmur em material ABS, com a presença de uma deformidade tipo CAME, a fim de mimetizar uma situação de impacto femoroacetabular. Após as operações serem realizadas por 16 cirurgiões, os fêmures foram comparados a um modelo prévio com e outro sem deformidade pelo programa Cloudcompare, sendo avaliados ao final parâmetros como diferença volumétrica entre os fêmures operados, com e sem deformidade, distância mínima e máxima entre eles, porcentagem da deformidade ressecada, tempo estimado para ressecção total da deformidade, além de uma análise qualitativa feita com base nas imagens e gráficos fornecidos pelo programa representando as áreas das peças efetivamente ressecadas. Resultados A velocidade média de resseção foi de 34,66mm3/minuto (DP = 46 mm3/min, max = 147,33 mm3/min; min = −2,66 mm3/min). A média de ressecção obtida foi de 26,2% (DP = 34,7%, max = 111%; min = −2%). A análise qualitativa demonstrou uma hiporresecção das deformidades e, por vezes, hiperresecção de áreas não deformadas. O simulador foi muito bem avaliado pelos cirurgiões, tendo uma sensação tátil bem semelhante à cirurgia real segundo os mesmos. Conclusão Simuladores artroscópicos se mostraram muito úteis no treinamento de cirurgiões menos experientes. artroscópica D 2017 ABS femoroacetabular 1 Cloudcompare operados eles ressecada ressecadas 3466mm3minuto mmminuto 34 66mm3 minuto mm DP 4 mm3min mmmin mm3 mm3/min 14733 147 33 147,3 266 2 66 −2,6 mm3/min. . mm3/min) 262 26 26,2 347 7 34,7% 111% 111 −2%. −2% −2%) vezes deformadas mesmos experientes 201 3 66mm 1473 14 147, 6 −2, 26, 34,7 11 −2 20 34, −

Resumen En este artículo, investigo la materialidad de la edición brasileña de Methodo Zaba (1870), de autoría del polaco Napoleão Félix Zaba (1803-1885), buscando revelar relaciones con las prácticas escolares observables en los registros producidos, en 1871, por dos profesores de escuelas públicas de Bahía: José Lourenço Ferreira Cajaty y João Theodoro Araponga. Para ello, a través de una investigación bibliográfica y documental y entendiendo el impreso como objeto cultural complejo (Chartier, 1991, 1998) y producto de la industria escolar (Meda, 2015), en el texto presento las características formales y de contenido del material didáctico, y luego exploro la materialidad del método a la luz de la enseñanza y la cultura escolar, reconociendo posibles usos y apropiaciones en los informes de Cajaty y Araponga, con el objetivo de demostrar que los saberes y métodos de enseñanza son reelaborados y reinventado a través de experiencias y prácticas pedagógicas (Schueler, 2005), así como revelado en las interacciones de los individuos con el mundo en su forma material (Vidal, 2006). artículo 1870, 1870 , (1870) 18031885, 18031885 1803 1885 (1803-1885) producidos 1871 Bahía Araponga ello Chartier, Chartier (Chartier 1991 1998 Meda, Meda (Meda 2015, 2015 2015) didáctico Schueler, Schueler (Schueler 2005, 2005 2005) Vidal, Vidal (Vidal 2006. 2006 . 2006) 187 (1870 1803188 180 188 (1803-1885 199 201 200 18 (187 180318 (1803-188 19 20 1 (18 18031 (1803-18 2 (1 (1803-1 ( (1803- (1803 (180

Abstract In this paper, I investigate the materiality of the Brazilian edition of Zaba’s Method, authored by Polish writer Napoleon Felix Zaba, aiming to unveil its connections with observable school practices based on records produced in 1871 by two teachers in Bahia’s public education system: José Lourenço Ferreira Cajaty and João Theodoro Araponga. This is a bibliographic and documentary research. By addressing the printed material as a multifaceted cultural artifact (Chartier, 1990, 1998) and a product of the educational industry (Meda, 2015), I present the formal characteristics and content of this educational resource. Furthermore, I examine the materiality of the method in the context of teaching practices and school culture, analyzing its applications and adaptations, to demonstrate that knowledge and teaching methods are reworked and reinvented via pedagogical experiences and practices (Schueler, 2005), as well as revealed in individuals’ interactions with the world in its material form (Vidal, 2006). paper Zabas Zaba s Method 187 Bahias Bahia system Araponga research Chartier, Chartier (Chartier 1990 1998 Meda, Meda (Meda 2015, 2015 , 2015) resource Furthermore culture adaptations Schueler, Schueler (Schueler 2005, 2005 2005) individuals Vidal, Vidal (Vidal 2006. 2006 . 2006) 18 199 201 200 1 19 20 2

Resumo Neste artigo, investigo a materialidade da edição brasileira do Methodo Zaba (1870), de autoria do polonês Napoleão Félix Zaba (1803-1885), buscando desvelar relações com práticas escolares observáveis nos registros produzidos, em 1871, por dois professores do ensino público baiano: José Lourenço Ferreira Cajaty e João Theodoro Araponga. Para tanto, por meio de pesquisa bibliográfica e documental e entendendo o impresso como objeto cultural complexo (Chartier, 1991, 1998) e produto da indústria escolar (Meda, 2015), no texto, apresento as caraterísticas formais e o conteúdo do material didático e, depois, exploro a materialidade do método à luz do fazer docente e da cultura escolar, reconhecendo possíveis usos e apropriações nos relatos de Cajaty e Araponga, com o intuito de demonstrar que conhecimentos e métodos de ensino são reelaborados e reinventados por meio das experiências e práticas pedagógicas (Schueler, 2005), bem como se revelam nas interações dos indivíduos com o mundo em sua forma material (Vidal, 2006). artigo 1870, 1870 , (1870) 18031885, 18031885 1803 1885 (1803-1885) produzidos 1871 baiano Araponga tanto Chartier, Chartier (Chartier 1991 1998 Meda, Meda (Meda 2015, 2015 2015) texto depois Schueler, Schueler (Schueler 2005, 2005 2005) Vidal, Vidal (Vidal 2006. 2006 . 2006) 187 (1870 1803188 180 188 (1803-1885 199 201 200 18 (187 180318 (1803-188 19 20 1 (18 18031 (1803-18 2 (1 (1803-1 ( (1803- (1803 (180

Abstract Integrative network analysis (INA) is important for identifying gene modules or epigenetically regulated molecular pathways in diseases. This study evaluated the effect of excessive gestational weight gain (EGWG) on INA of differentially methylated regions, maternal metabolism and offspring growth. Brazilian women from “The Araraquara Cohort Study” with adequate pre-pregnancy body mass index were divided into EGWG (n=30) versus adequate gestational weight gain (AGWG, n=45) groups. The methylome analysis was performed on maternal blood using the Illumina MethylationEPIC BeadChip. Fetal-neonatal growth was assessed by ultrasound and anthropometry, respectively. Maternal lipid and glycemic profiles were investigated. Maternal triglycerides-TG (p=0.030) and total cholesterol (p=0.014); fetus occipito-frontal diameter (p=0.005); neonate head circumference-HC (p=0.016) and thoracic perimeter (p=0.020) were greater in the EGWG compared to the AGWG group. Multiple linear regression analysis showed that maternal DNA methylation was associated with maternal TG and fasting insulin, fetal abdominal circumference, and fetal and neonate HC. The DMRs studied were enriched in 142 biological processes, 21 molecular functions,and 17 cellular components with terms directed for the fatty acids metabolism. Three DMGMs were identified:COL3A1, ITGA4 and KLRK1. INA targeted chronic diseases and maternal metabolism contributing to an epigenetic understanding of the involvement of GWG in maternal metabolism and fetal-neonatal growth. (INA (EGWG regions Study prepregnancy pre pregnancy n=30 n30 n 30 (n=30 AGWG, (AGWG n=45 n45 45 groups BeadChip Fetalneonatal Fetal neonatal anthropometry respectively investigated triglyceridesTG triglycerides p=0.030 p0030 p 0 030 (p=0.030 p=0.014 p0014 014 (p=0.014) occipitofrontal occipito frontal p=0.005 p0005 005 (p=0.005) circumferenceHC circumference HC p=0.016 p0016 016 (p=0.016 p=0.020 p0020 020 (p=0.020 group insulin 14 processes 2 functionsand functions 1 identifiedCOL3A1, identifiedCOL3A1 identifiedCOLA identified COL3A1, COL3A1 COL A identified:COL3A1 ITGA KLRK1 KLRK fetalneonatal n=3 n3 3 (n=3 n=4 n4 4 p=0.03 p003 03 (p=0.03 p=0.01 p001 01 (p=0.014 p=0.00 p000 00 (p=0.005 (p=0.01 p=0.02 p002 02 (p=0.02 identifiedCOL identifiedCOL3A COLA COL3A identified:COL3A n= (n= p=0.0 p00 (p=0.0 (p=0.00 (n p=0. p0 (p=0. p=0 (p=0 p= (p= (p

RESUMEN Objetivo: describir el proceso de desarrollo, validación y evaluación de una cartilla educativa para prevenir el acoso escolar transfóbico. Método: se trata de un estudio metodológico, realizado de febrero a diciembre de 2022 en una escuela pública de João Pessoa, Paraíba, Brazil. La cartilla educativa fue elaborada de acuerdo con la trayectoria metodológica propuesta por Echer, y sometida a validación de contenido y evaluación semántica por jueces expertos y docentes de la Escuela Primaria II, respectivamente. En el análisis de los datos, se utilizaron los coeficientes de validez de contenido y de correlación intraclase, y el índice de concordancia semántica. Resultados: la cartilla educativa tuvo su contenido validado con un coeficiente de validez de 0,981 y un coeficiente de correlación intraclase de 0,833 para el conjunto de ítems del instrumento de evaluación. En la evaluación semántica, los docentes consideraron comprensible el cuadernillo, con un nivel mínimo de acuerdo del 94%. Conclusión: la cartilla desarrollada fue considerada válida por los jueces, para ser utilizada con docentes, de manera individual y en acciones de educación continua o de salud, con el fin de contribuir a la prevención del acoso escolar transfóbico en la escuela. Objetivo desarrollo Método metodológico 202 Pessoa Paraíba Brazil Echer II respectivamente datos Resultados 0981 0 981 0,98 0833 833 0,83 cuadernillo 94 94% Conclusión salud 20 098 98 0,9 083 83 0,8 9 2 09 0, 08 8

ABSTRACT Objective: to describe the process of developing, validating and assessing an educational booklet to prevent transphobic bullying at school. Method: this is a methodological study, carried out from February to December 2022 at a public school in João Pessoa, Paraíba, Brazil. The educational booklet was developed in accordance with the methodological trajectory proposed by Echer, and submitted to content validity and semantic assessment by expert judges and Elementary School II teachers, respectively. In data analysis, content validity and Intraclass Correlation Coefficients were used, in addition to semantic agreement index. Results: the educational booklet had its content validated with a validity coefficient of 0.981 and an Intraclass Correlation Coefficient of 0.833 for the set of items in the assessment instrument. In semantic assessment, teachers considered the booklet understandable, with a minimum agreement level of 94%. Conclusion: the booklet developed was considered valid by judges, to be used with teachers, individually and in continuing education or health actions, in order to contribute to preventing transphobic bullying at school. Objective developing Method study 202 Pessoa Paraíba Brazil Echer respectively analysis index Results 0981 0 981 0.98 0833 833 0.83 instrument understandable 94 94% Conclusion actions 20 098 98 0.9 083 83 0.8 9 2 09 0. 08 8

RESUMO Objetivo: Descrever o processo de desenvolvimento, validação e avaliação de cartilha educacional para prevenção do bullying transfóbico na escola. Método: Trata-se de um estudo metodológico, realizado no período de fevereiro a dezembro de 2022 em uma escola pública de João Pessoa, Paraíba, Brasil. A cartilha educacional foi desenvolvida de acordo com a trajetória metodológica proposta por Echer, e submetida à validação de conteúdo e avaliação semântica por juízes especialistas e professores do Ensino Fundamental II, respectivamente. Na análise dos dados, utilizaram-se os coeficientes de validade de conteúdo e correlação intraclasse, e o índice de concordância semântica. Resultados: A cartilha educacional teve seu conteúdo validado com coeficiente de validade de 0,981 e coeficiente de correlação intraclasse de 0,833 para o conjunto de itens do instrumento de avaliação. Na avaliação semântica, os professores consideraram a cartilha compreensível, com nível de concordância mínima de 94%. Conclusão: A cartilha desenvolvida foi considerada válida por juízes, para ser utilizada com professores, de forma individual e em ações de educação permanente ou em saúde, a fim de contribuir na prevenção do bullying transfóbico na escola. Objetivo desenvolvimento Método Tratase Trata se metodológico 202 Pessoa Paraíba Brasil Echer II respectivamente dados utilizaramse utilizaram Resultados 0981 0 981 0,98 0833 833 0,83 compreensível 94 94% Conclusão saúde 20 098 98 0,9 083 83 0,8 9 2 09 0, 08 8

Abstract This qualitative, descriptive, and exploratory documentary and field research aimed to analyze how children and adolescents are included in the formulation of public mental health policies. The document analysis database consisted of reports from Health Conferences (national, state, and municipal), minutes of meetings of the Health Council (national, state, and municipal), and memories of the Thematic Commission on Mental Health (state and municipal). Nine counselors or former health counselors participated in this study through an individual interview with a semi-structured script. Furthermore, the theoretical framework for the analysis of this research was based on the communicative action of Jürgen Habermas. The themes that emerged from the documentary research included the guidelines for intersectoral processes, as well as the expansion of beds for children and adolescents. In addition, the interviews indicated the lack of discussion on the subject, predominance of the punitive perspective, and need for a broader debate. The lack of intersubjective spaces for democratic listening compromises communicative action, resulting in the invisibility of children and adolescents in the policy formulation process and reduced opportunities for participation and social control. qualitative descriptive policies national, national (national state municipal, municipal , municipal) municipal. . semistructured semi structured script Furthermore Habermas processes addition subject perspective debate control

Resumo O objetivo do trabalho foi analisar como crianças e adolescentes são contemplados nos processos de participação para a formulação das políticas públicas de saúde mental. Pesquisa qualitativa, descritiva e exploratória de caráter documental e de campo. A base de dados da análise documental consistiu em: relatórios das Conferências de Saúde (nacional, estadual e municipal), atas de reuniões do Conselho de Saúde (nacional, estadual e municipal) e memórias da Comissão Temática de Saúde Mental (estadual e municipal). Participaram deste estudo nove conselheiros ou ex-conselheiros de saúde, por meio de uma entrevista individual com roteiro semiestruturado. Como marco teórico de análise desta pesquisa, foi proposto o agir comunicativo de Jürgen Habermas. Dentre os temas que emergiram da pesquisa documental, encontram-se as diretrizes de processos intersetoriais, bem como a ampliação de leitos para crianças e adolescentes. As entrevistas apontaram a falta de discussão da temática, predomínio da perspectiva punitivista e para a necessidade de um debate mais amplo. A falta de espaços intersubjetivos de escuta democrática compromete o agir comunicativo, ocasionando a invisibilização da criança e do adolescente no processo de formulação da política e enfraquecendo os espaços de participação e controle social. mental qualitativa campo em nacional, nacional (nacional municipal, municipal , municipal. . exconselheiros ex semiestruturado Habermas encontramse encontram se intersetoriais temática amplo social

ABSTRACT. Management systems that include trees tend to provide higher amounts of plant biomass to the soil, contributing to the increase in carbon (C) and nitrogen (N) stocks. This study simulated C and N stocks and their compartments in a crop-livestock-forest integration system in the edafoclimatic conditions of the Maranhão Cerrado using the Century 4.5 model. The evaluated areas were native Cerrado vegetation (NV) and crop-livestock-forest integration (CLFI). The calibration process gradually modified the model parameters to better fit the simulated and observed soil C and N stocks. The best fit between the data was obtained after changes in the main parameters (DEC3(2), DEC4, and DEC5) that controlled the rate of decomposition of soil organic matter. C and N stocks increased by 14% and 15%, respectively, over 14 years after replacing NV with CLFI. The slow compartment of C presented greater sensitivity to changes in management, with an increase of 47% compared with that of NV. The active compartment increased by 31% and the passive compartment remained constant for over 14 years. Future scenarios, where pasture was maintained between the eucalyptus trees and the scenario that allowed the soybean, corn, and Brachiaria rotation between the trees, were more effective, accumulating approximately 37 Mg C ha-1. The continuous contribution of residues from the trees and pasture increased C and N stocks in the long-term in the slow fraction, where the total organic carbon increased from 32 to 36 Mg ha-1 when NV was replaced with CLFI. The model predicted the C and N stocks with accuracies ranging from 1 to 11% of the observed values. ABSTRACT (C (N croplivestockforest crop livestock forest 45 4 5 4. (NV CLFI . (CLFI) DEC32, DEC32 DEC DEC3 2 , (DEC3(2) DEC4 DEC5 matter 15 15% respectively management 47 31 scenarios soybean corn effective 3 ha1. ha1 ha 1. longterm long term fraction ha- 11 values (CLFI (DEC3(2 (DEC3( (DEC3 (DEC

The aim of this work was to extract and characterize pectin from lyophilized noni pulp (Morinda citrifolia Linn.) at three different pHs using different extractor agents and to evaluate anti-viral activity. The extraction of high yield (acid extraction) was subjected to sulfation procedure. Fourier transform infrared spectroscopy and proton nuclear magneticresonance analysis were used to calculate the degree of methylation of pectin from acid extraction and its sulfated derivative. The data obtained for the degree of methylation of noni pectin and sulfated pectin were 30.3 and 30.7, respectively. Pectin was subjected to acute oral toxicity testing in mice. The results showed that pectin had a pro-inflammatory effect, and sulfated pectin had an anti-inflammatory effect. Both pectins were also evaluated for herpes simplex virus activity in vitro, and although they successfully inhibited virus replication, the sulfated pectins were cytotoxic. Morinda Linn. Linn antiviral anti viral procedure derivative 303 30 3 30. 307 7 30.7 respectively mice proinflammatory pro inflammatory effect antiinflammatory vitro replication cytotoxic

Abstract Green manure (GM) may reduce the use of chemical fertilizers, been an ecologically appropriate strategy to cultivation of medicinal plants. Crotalaria juncea, is one of the most used because it adapts to different climatic and high nitrogen content. Origanum vulgare. is widely used in cooking, pharmaceutical, cosmetic industries and food products. The objectives of this study were to evaluate the GM on biomass, essential oil (EO), phenolic and antioxidant. The experiment consisted: control; 150, 300, 450, and 600 g (Sh= leaves+steam) more 200 g roots (R); 600 g aerial part; 200 g roots; and soil with 300 g cattle manure per pot. The highest dry weights were observed in the presence of GM and cattle manure (90 days). The control had an EO production 75% lower in relation to the dose of 450 g GM (Sh+R). Principal component analysis showed that GM and cattle manure positively influenced the dry weight, content, yield, and EO constituents, and total flavonoids. The GM contributed to the accumulation of the major EO compounds (trans-sabinene hydrate, thymol, terpinen-4-ol). The GM management may be beneficial for cultivating, because it can increase the production of biomass and the active components, in addition to being an inexpensive resource. (GM fertilizers plants juncea content vulgare cooking pharmaceutical products EO, , (EO) antioxidant consisted 150 60 Sh= Sh (Sh leaves+steam leavessteam leaves steam 20 R (R) part 30 pot 90 (9 days. days . days) 75 45 Sh+R. ShR Sh+R (Sh+R) weight yield constituents flavonoids transsabinene trans sabinene hydrate thymol terpinen4ol. terpinen4ol terpinenol terpinen 4 ol terpinen-4-ol) cultivating components resource (EO 15 6 2 (R 3 9 ( 7 (Sh+R terpinen-4-ol 1

Phytochemical study of Psychotria schlechtendaliana (Rubiaceae) aerial parts resulted in the isolation of alkaloids 4 N oxide harmane (1) and strictosidinic acid (2), and the terpenoids sitosterol, estigmasterol, α-amyrin, β-amyrin and betulinic acid. The crude extract (CE), its fractions (hexane FH, chloroform FC, ethyl acetate FEA, hydromethanolic FHM, alkaloidal chloroform FCOH, alkaloidal aqueous FAq) and majority alkaloid (1) were investigated for their antiproliferative potential against nine human tumor cells lines and one non-tumoral human cell line (HaCat). CE, FH and FEA fractions exhibited strong growth inhibition for ovary cells (OVCAR-3, GI50 = 5.89; 1.36 and 6.59 μg mL-1, respectively) and FC, FH and FAq fractions showed potent activity on the growth of leukemia cell lines (K562, GI50 = 1.92; 7.23 and 8.81 μg mL-1, respectively). Compound 1 exhibited selective antiproliferative activity to breast cancer (MCF-7, GI50 = 32.7 μg mL-1) and was non-toxic to HaCat cells. To evaluate the anti-inflammatory effect, models of ear edema induced by croton oil and the enzyme myeloperoxidase (MPO) were used. FH and FC fractions exhibited anti-inflammatory effect and reduce ear edema compared to the control group. These fractions showed results superior to those exhibited by indomethacin (75.1%), FH (97.5%) and FC (95.5%) fractions. Rubiaceae (Rubiaceae (1 2, 2 , (2) sitosterol estigmasterol αamyrin, αamyrin α amyrin, amyrin α-amyrin βamyrin β CE (CE) hexane FHM FCOH nontumoral non tumoral HaCat. . (HaCat) OVCAR3, OVCAR3 OVCAR 3, 3 (OVCAR-3 GI GI5 5.89 589 5 89 136 36 1.3 659 6 59 6.5 mL1, mL1 mL 1, mL-1 respectively K562, K562 K (K562 1.92 192 92 723 7 23 7.2 881 8 81 8.8 respectively. MCF7, MCF7 MCF 7, (MCF-7 327 32 32. nontoxic toxic antiinflammatory anti inflammatory MPO (MPO used group 75.1%, 751 75.1% 75 (75.1%) 97.5% 975 97 (97.5% 95.5% 955 95 (95.5% ( (2 (CE (HaCat (OVCAR- 5.8 58 13 1. 65 6. mL- K56 (K56 1.9 19 9 72 7. 88 8. (MCF- 75.1 (75.1% 97.5 (97.5 95.5 (95.5 (OVCAR 5. K5 (K5 (MCF 75. (75.1 97. (97. 95. (95. (K (75. (97 (95 (75 (9 (7