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Imputação de dados ausentes em séries temporais de carbonatação dos concretos
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Campos Neto, Tiago Ferreira

; Cascudo, Oswaldo

Ambiente Construído

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Dez 2024, Volume 24 elocation e136386

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O crescente uso de modelos contemporâneos de previsão de frentes de carbonatação, como redes neurais artificiais, exige maior rigor sobre a completude dos bancos de dados. Tratar os bancos de dados de profundidades de carbonatação como séries temporais é uma alternativa favorável à garantia da qualidade. Dessa forma, este artigo tem o objetivo de identificar a melhor técnica de imputação de dados ausentes em séries temporais de profundidades de carbonatação de concretos com diferentes composições. Como banco de dados foram utilizadas as informações coletadas de concretos submetidos à carbonatação natural ao longo de 20 anos de exposição pertencentes ao grupo GEDur/UFG. Foram experimentadas dez técnicas de imputação entre as quais destacam-se, foward fill, média móvel, interpolação e filtro de Kalman. Todas as técnicas e análises foram implementadas utilizando linguagem de programação em python dentro de um ambiente de desenvolvimento integrado. Com base nas métricas de desempenho e análise visual, constatou-se que a interpolação spline monotônica cúbica capturou o padrão da curva de profundidade de carbonatação em função do tempo com maior precisão e acurácia, alcançando índice de desempenho de 0,998 e RMSE entre 0,106mm e 0,863mm dependendo da amostra de concreto. artificiais qualidade forma composições 2 GEDurUFG GEDur UFG GEDur/UFG destacamse, destacamse destacam se, se destacam-se fill móvel Kalman integrado visual constatouse constatou acurácia 0998 0 998 0,99 0106mm mm 106mm 0863mm 863mm concreto 099 99 0,9 09 9 0,

Abstract The growing use of contemporary models for predicting carbonation fronts, such as artificial neural networks, requires greater rigor in terms of database completeness. Treating carbonation depth databases as time series is a favorable alternative for quality assurance. Therefore, the aim of this article is to identify the best technique for imputing missing data in time series of carbonation depths of concrete with different compositions. The database used was information collected from concretes subjected to natural carbonation over 20 years of exposure belonging to the GEDur/UFG. Ten imputation techniques were tried, such as foward fill, moving average, interpolation and Kalman filter. All the techniques and analyses were implemented using the Python programming language in an integrated development environment. Based on the performance metrics and visual analysis, it was found that monotonic cubic spline interpolation captured the pattern of the carbonation depth curve as a function of time with greater precision and accuracy, achieving a performance index of 0.998 and RMSE between 0.106 mm and 0.863 mm depending on the concrete sample. fronts networks completeness assurance Therefore compositions 2 GEDurUFG GEDur UFG GEDur/UFG tried fill average filter environment analysis accuracy 0998 0 998 0.99 0106 106 0.10 0863 863 0.86 sample 099 99 0.9 010 10 0.1 086 86 0.8 09 9 0. 01 1 08 8

https://doi.org/10.1590/s1678-86212024000100748

Fatores associados à internação de usuários encaminhados pela atenção primária para acompanhamento em Centros de Atenção Psicossociais do município de São Paulo, Brasil
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Sanine, Patricia Rodrigues

; Godoi, Lídia Pereira da Silva

; Rosa, Tereza Etsuko da Costa

; Garcia, Érica Marvila

; Belotti, Lorrayne

; Campos, Rosana Teresa Onocko

; Tanaka, Oswaldo Yoshimi

Ciência & Saúde Coletiva

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2024, Volume 29 Nº 2 elocation e19932022

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract This study evaluated factors associated with hospitalization related to the mental health of people undergoing follow-up in Psychosocial Care Centers (CAPS, in Portuguese) in the city of São Paulo, Brazil, referred from Primary Health Care (PHC). This was an evaluative study conducted with 297 individuals in 24 adult CAPS. This study analyzed the prevalence ratios (PR) and their respective 95% confidence intervals (95% CI), obtained through Poisson Regression with robust variance. A statistically significant association was found with hospitalization during follow-ups in CAPS: having health insurance and/or medical plan; waiting time between the diagnosis and the first consultation with a non-medical professional of more than seven days; not having received medical advice regarding how long to use medication; not having received a psychopharmaceutical prescription at PHC; and having a medical history of the hospitalization due to mental health. The results warn of the need to expand access to the more socially vulnerable population, in addition to a restructuring of the services in order to provide more interactive and inclusive practices geared toward the singularities of the users.

Resumo Avaliaram-se os fatores associados à internação relacionadas à saúde mental de pessoas em acompanhamento nos Centros de Atenção Psicossocial (CAPS) do município de São Paulo, encaminhadas pela atenção primária (APS). Pesquisa avaliativa com 297 pessoas em 24 CAPS Adulto. Analisaram-se as razões de prevalência (RP) e seus respectivos intervalos de confiança de 95% (IC), obtidas por meio da regressão de Poisson com variância robusta. Mostraram associação estatisticamente significativa com a internação durante o acompanhamento no CAPS: ter plano de saúde/convênio médico; tempo de espera entre diagnóstico e primeiro atendimento com profissional não médico maior que sete dias; não ter sido orientado sobre o tempo de uso da medicação; não receber prescrição de psicofármaco na APS; e ter histórico de ocorrência de internação por saúde mental. Os resultados alertam para a necessidade de ampliação do acesso à população com maior vulnerabilidade social, além de uma reestruturação dos serviços para a oferta de prática mais articuladas e inclusivas, voltadas às singularidades dos usuários.

https://doi.org/10.1590/1413-81232024292.19932022

Fatores associados à internação de usuários encaminhados pela atenção primária para acompanhamento em Centros de Atenção Psicossociais do município de São Paulo, Brasil Paulo
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Sanine, Patricia Rodrigues

; Godoi, Lídia Pereira da Silva

; Rosa, Tereza Etsuko da Costa

; Garcia, Érica Marvila

; Belotti, Lorrayne

; Campos, Rosana Teresa Onocko

; Tanaka, Oswaldo Yoshimi

Ciência & Saúde Coletiva

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2024, Volume 29 Nº 2 elocation e19932022

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232024292.19932022

Leishmania (Sauroleishmania) tarentolae versus pathogenic species: comparative evaluation of protease activity, glycoconjugates, resistance to complement and metabolome composition Sauroleishmania (Sauroleishmania species activity glycoconjugates
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Andrade, Filipe Fideles Duarte

; Vitório, Jéssica Gardone

; Canuto, Gisele André Baptista

; Nunes, Fernanda Freire Campos

; Rodrigues, Isabela Aurora

; Almeida, Ana Paula Martins Morais

; Nascimento, Frederico Crepaldi

; Costa, Adriana Oliveira

; Vieira, Tamara da Silva

; Silva, Ana Carolina Carvalho

; André, Leiliane Coelho

; Gontijo, Célia Maria Ferreira

; Junqueira, Caroline

; Toledo, Juliano Simões de

; Fernandes, Ana Paula

; Soares, Rodrigo Pedro

Memórias do Instituto Oswaldo Cruz

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2024, Volume 119 elocation e230243

Resumo: En | Texto: En | PDF: En

BACKGROUND Leishmania tarentolae is a non-pathogenic species found in lizards representing an important model for Leishmania biology. However, several aspects of this Sauroleishmania remain unknown to explain its low level of virulence. OBJECTIVES We reported several aspects of L. tarentolae biology including glycoconjugates, proteolytic activities and metabolome composition in comparison to pathogenic species (Leishmania amazonensis, Leishmania braziliensis, Leishmania infantum and Leishmania major). METHODS Parasites were cultured for extraction and purification of lipophosphoglycan (LPG), immunofluorescence probing with anti-gp63 and resistance against complement. Parasite extracts were also tested for proteases activity and metabolome composition. FINDINGS Leishmania tarentolae does not express LPG on its surface. It expresses gp63 at lower levels compared to pathogenic species and, is highly sensitive to complement-mediated lysis. This species also lacks intracellular/extracellular activities of proteolytic enzymes. It has metabolic differences with pathogenic species, exhibiting a lower abundance of metabolites including ABC transporters, biosynthesis of unsaturated fatty acids and steroids, TCA cycle, glycine/serine/threonine metabolism, glyoxylate/dicarboxylate metabolism and pentose-phosphate pathways. MAIN CONCLUSIONS The non-pathogenic phenotype of L. tarentolae is associated with alterations in several biochemical and molecular features. This reinforces the need of comparative studies between pathogenic and non-pathogenic species to elucidate the molecular mechanisms of virulence during host-parasite interactions. nonpathogenic non However L glycoconjugates amazonensis braziliensis major. major . major) LPG, , (LPG) antigp63 antigp anti gp anti-gp6 complement surface gp6 complementmediated mediated lysis intracellularextracellular intracellular extracellular enzymes transporters steroids cycle glycineserinethreonine glycine serine threonine glyoxylatedicarboxylate glyoxylate dicarboxylate pentosephosphate pentose phosphate pathways features hostparasite host parasite interactions (LPG antigp6 anti-gp

https://doi.org/10.1590/0074-02760230243

Different profiles of chemokines, cytokines and cell growth factors in plasma samples from patients with leprosy, leprosy reactions and households contacts chemokines
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de Carvalho, Jairo Campos

; Pascoal-Xavier, Marcelo Antônio

; Araújo, Marcelo Grossi

; Teixeira-Carvalho, Andrea

; Martins-Filho, Olindo Assis

; Peruhype-Magalhães, Vanessa

; Coelho-dos-Reis, Jordana Grazziela Alves

; Araújo, Márcio Sobreira Silva

Memórias do Instituto Oswaldo Cruz

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2024, Volume 119 elocation e230129

Resumo: En | Texto: En | PDF: En

BACKGROUND Leprosy is a highly neglected disease that is considered a serious public health problem in many countries. This illness is characterised by a variety of clinical and histopathological manifestations that are related to the patient immune response. OBJECTIVES This work aimed evaluate the profile of circulating immune mediators in the plasma from patients classified clinically as paucibacillary (PB), multibacillary (MB), households contacts (HHC), type1 leprosy reaction (T1R), type2 leprosy reaction (T2R) and control individuals without medical history of leprosy (CTL). METHODS To assessment of the plasma immune mediators was used multiplex microbeads immunoassay “Luminex”. FINDINGS The results showed that patients (PB) had a regulatory-biased profile, while MB revealed a pro-inflammatory trend of highly expressed biomarkers. HHC display conspicuously increased levels in the plasma of the chemokines (CCL2, CCL3, CCL4, CCL5 and CXCL8), pro-inflammatory cytokines (IFN-γ,TNF and IL-1β), modulating cytokines (IL-9 and IL-1Ra) and growth factors (PDGF, G-CSF and IL-2). Interestingly, HHC displayed superior production of IFN-γ as compared to other leprosy groups, indicating a putative protective role for this cytokine during chronic Mycobacterium leprae exposure. MAIN CONCLUSION Further investigations are currently underway to elucidate the potential of these mediators as biomarkers applicable to the diagnosis/prognosis of leprosy and also T1R and T2R leprosy reactions. countries response PB, PB , MB, (MB) HHC, (HHC) type T1R, TR T R (T1R) (T2R CTL. CTL . (CTL) Luminex. Luminex “Luminex” (PB regulatorybiased regulatory biased proinflammatory pro inflammatory CCL2, CCL2 CCL (CCL2 CCL3 CCL4 CXCL8, CXCL8 CXCL CXCL8) IFNγ,TNF IFNγTNF IFN γ,TNF γ TNF IL1β, IL1β ILβ IL 1β β IL-1β) IL9 9 (IL- IL1Ra ILRa 1Ra Ra IL-1Ra PDGF, PDGF (PDGF GCSF G CSF IL2. IL2 2 IL-2) Interestingly IFNγ groups exposure diagnosisprognosis diagnosis prognosis reactions (MB (HHC (T1R (CTL “Luminex (CCL γTNF IL-1β (IL IL-2 IL-

https://doi.org/10.1590/0074-02760230129

Evaluation of lip diseases in peddlers on two beaches of Guarujá/Brazil: An observational study Guarujá/Brazil GuarujáBrazil Guarujá Brazil
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Roman-Torres, Caio Vinicius G.

; Gracia Neto, Edson

; Pimentel, Angelica Castro

; Oswaldo Schwartz-Filho, Humberto

; Sendyk, Wilson Roberto

; Campos, Luana

Brazilian Dental Journal

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2024, Volume 35 elocation e24-6044

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A exposição solar é responsável pela maior parte das doenças labiais e, quando diagnosticadas tardiamente, o prognóstico é desfavorável, e os tratamentos costumam ser mutilantes, paliativos e onerosos. Este estudo teve como objetivo avaliar a prevalência de doenças labiais e os fatores associados ao seu desenvolvimento em vendedores ambulantes de duas praias do litoral do Guarujá/Brasil. Os dados foram coletados por meio de exame clínico e aplicação de questionário a 182 trabalhadores. Eles também receberam um folder explicativo com informações sobre cuidados bucais e a importância do uso do protetor solar na prevenção do câncer labial. Todos os trabalhadores com diagnóstico de lesão labial foram encaminhados para tratamento odontológico. A prevalência de alterações labiais foi de 40,7% (n = 70); além disso, os fumantes incluíram 27,5% e o consumo de álcool prevaleceu em 20,3% dos participantes. Quanto à proteção individual, 72% dos trabalhadores relataram usar chapéu ou boné com frequência, 48,4% relataram usar protetor solar corporal e apenas 11,5% relataram usar protetor labial. Não houve diferenças significativas em fatores como alcoolismo e tabagismo para o diagnóstico de lesão labial. Porém, ao caracterizar esses fatores, 48,6% dos participantes que bebem ou fumam apresentaram alterações labiais. Pode-se concluir que a população de vendedores ambulantes das praias do Guarujá apresenta alto índice de alteração labial, o que sugere a necessidade de implementação de estratégias educativas em saúde que visem orientar a população sobre os fatores de risco e medidas preventivas das lesões labiais. tardiamente desfavorável mutilantes onerosos GuarujáBrasil Brasil Guarujá/Brasil 18 odontológico 407 40 7 40,7 n 70 70) disso 275 27 5 27,5 203 20 3 20,3 individual 72 frequência 484 48 4 48,4 115 11 11,5 Porém 486 6 48,6 Podese Pode se 1 40, 2 27, 20, 48, 11,

Abstract Sun exposure is responsible for most lip lesions and, when diagnosed late, the prognosis is unfavorable. Treatments are usually mutilating, palliative, and expensive. This study aimed to evaluate the prevalence of lip diseases and factors associated with its development in peddlers on two beaches of the Guarujá/Brazil coast. Data were collected by clinical examination and use of a questionnaire of 182 peddlers on the beaches. They also received an explanatory folder with information about oral care, and the importance of the use of sunscreen for cancer prevention. All workers diagnosed with lip injuries were referred for dental treatment. The prevalence of lip alterations was 40.7% (n = 70), furthermore, smokers included 27.5%, and alcohol consumption was 20.3%. Regarding selfie protection, 72% of workers reported wearing a hat or cap frequently, 48.4% reported using body sunscreen, and only 11.5% reported using lip balm. There were no significant differences in factors such as alcoholism and smoking related to lip lesions diagnosis. However, when characterizing these factors, 48.6% of those who drink, or smoke have lip alterations. It can be concluded that the population of peddlers on the beaches of Guarujá has a high rate of lip alteration which suggests the need to implement educational health strategies aimed at informing the population about risk factors and preventive measures for lip diseases. late unfavorable mutilating palliative expensive GuarujáBrazil Brazil coast 18 care prevention treatment 407 40 7 40.7 n 70, 70 , 70) furthermore 275 27 5 27.5% 203 20 3 20.3% protection 72 frequently 484 48 4 48.4 115 11 11.5 balm diagnosis However 486 6 48.6 drink 1 40. 2 27.5 20.3 48. 11. 27. 20.

https://doi.org/10.1590/0103-6440202406044

Estimativa de frentes de carbonatação baseada em análises estatísticas: aplicando modelo europeu em território brasileiro estatísticas
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Campos Neto, Tiago Ferreira

; Cascudo, Oswaldo

; Oliveira, Andrielli Morais de

Ambiente Construído

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Jul 2023, Volume 23 Nº 3 Páginas 167 - 185

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este artigo tem como objetivo avaliar a aplicabilidade do modelo de predição de frentes de carbonatação preconizado pelo CEB Bulletin 34 (2006) em território brasileiro. Para isso, dados de concretos produzidos em laboratório e expostos à carbonatação natural por 10 anos foram utilizados como balizadores. Tempo de exposição, relação água/ligante, adição mineral e cura foram consideradas variáveis independentes, ao passo que a profundidade e o coeficiente de carbonatação como dependentes. Foram realizadas análises de variância e regressão linear entre os dados reais e os estimados, de maneira a estabelecer critériosque permitiram constatar a aplicabilidade do modelo. Consideraram-se condições ambientais e climáticas da cidade de Goiânia, GO, localizada na zona tropical Brasil Central, com clima quente semiúmido. Como resultado, com base nos coeficientes de correlação e determinação - iguais a 0,83 e 0,68 respectivamente - conclui-se que o modelo precisa ser revisto antes de ser aplicado no Brasil. Mais especificamente, o fator de resistência inversa efetiva à carbonatação natural, que associa a relaçãoágua/ligante e o tipo de adição, deve ser reajustado de maneira que represente os efeitos em ordem de grandeza semelhantes às reais. 3 2006 (2006 brasileiro isso 1 balizadores exposição águaligante água ligante água/ligante independentes dependentes estimados Consideraramse Consideraram se Goiânia GO Central semiúmido resultado 083 0 83 0,8 068 68 0,6 concluise conclui especificamente relaçãoágualigante relaçãoágua 200 (200 08 8 0, 06 6 20 (20 2 (2 (

Abstract This paper aims to evaluate the applicability of the carbonation front prediction model recommended by CEB Bulletin 34 (2006) in Brazilian territory. For this, data from concrete mixtures produced in laboratory and exposed to natural carbonation for 10 years were used as benchmarks. Time of exposure, water/binder ration, different types of mineral admixtures and curing were considered as independent variables, while carbonation depth and coefficient as dependent ones. Analysis of variance and linear regression were performed between the actual and estimated data in order to establish criteria that allowed verifying the applicability of the model. It was considered the environmental and climatic conditions of the city of Goiânia/GO located in the tropical zone of Brazil Central with a hot semi-humid climate. As a result, based on the correlation and determination coefficients - equal to 0.83 and 0.68 respectively - it is concluded that the model needs to be revised before being applied in Brazil. More specifically, the inverse effective normal carbonation resistance factor, which associates the water/binder ration and the type of mineral admixture, should be readjusted so that it represents the effects in orders of magnitude similar to the real ones. 3 2006 (2006 territory this 1 benchmarks exposure waterbinder water binder variables ones GoiâniaGO Goiânia GO semihumid semi humid climate result 083 0 83 0.8 068 68 0.6 specifically factor admixture 200 (200 08 8 0. 06 6 20 (20 2 (2 (

https://doi.org/10.1590/s1678-86212023000300681

Leptospira interrogans insoluble fraction as a potential antigen source for lateral flow immunochromatography
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Campos, Hevandro de Souza

; Silva, Edimilson Domingos da

; Lima, Gerson Silva de

; Resende, Rafael de Oliveira

; Burth, Patricia

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220265

Resumo: En | Texto: En | PDF: En

BACKGROUND Leptospirosis is an emerging zoonosis that affects humans and animals. Immunochromatography rapid test is widely used for early diagnosis of leptospirosis, but with low sensitivity and specificity. OBJECTIVES To evaluate Leptospira interrogans insoluble fraction as a potential antigen source for lateral flow immunochromatography. METHODS Insoluble fraction derived from the crude bacterial extract was obtained by serial centrifugation. The polypeptide profile was determined using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Immune reactivity of this fraction was assessed by Western Blotting and lateral flow immunochromatography (LFI). It was tested 160 microagglutination test (MAT)-positive sera from patients in the acute phase, 100 MAT-negative sera from patients with acute febrile illness, and 45 patients with other infectious diseases. FINDINGS There was a predominance of low molecular mass-polypeptide bands, ranging from 2 to 37 kDa. The antibody reactivity of theses polypeptides was found to range from 13-50%, especially between 10 and 38 kDa. Among MAT-positive sera of patients with leptospirosis in the acute phase, 97% were also positive in LFI, indicating high sensitivity. Among MAT-negative sera, all were negative in LFI, indicating high specificity. Only 2% of cross-reactivity was detected. CONCLUSION The insoluble fraction can be a valuable antigen source for development of point-of-care diagnosis test for leptospirosis. animals specificity centrifugation sulfatepolyacrylamide sulfate polyacrylamide SDSPAGE. SDSPAGE SDS PAGE . (SDS-PAGE) LFI. LFI (LFI) 16 MATpositive MAT phase MATnegative illness 4 diseases masspolypeptide mass bands 3 kDa 1350%, 1350 13 50%, 50 13-50% 1 97 crossreactivity cross detected pointofcare point care (SDS-PAGE (LFI 1350% 135 50% 5 13-50 9 13-5 13-

https://doi.org/10.1590/0074-02760220265

First report of Leishmania (Mundinia) martiniquensis in South American territory and confirmation of Leishbunyavirus infecting this parasite in a mare Mundinia (Mundinia
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Mendes Junior, Artur Augusto Velho

; Filgueira, Camila Patrício Braga

; Miranda, Luciana de Freitas Campos

; de Almeida, Adilson Benedito

; Cantanhêde, Lilian Motta

; Fagundes, Aline

; Pereira, Sandro Antônio

; Menezes, Rodrigo Caldas

; Cupolillo, Elisa

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220220

Resumo: En | Texto: En | PDF: En

BACKGROUND Epidemiological data related to leishmaniases or Leishmania infection in horses are scarce. However, studies carried out in different regions in the world showed equids parasitised by Leishmania braziliensis, L. infantum and L. martiniquensis. OBJECTIVES Identify the Leishmania species causing cutaneous leishmaniasis in a mare, living in Rio de Janeiro State (Brazil), and search the presence of Leishmania viruses in the isolated parasite. METHODS Isoenzymes and polymerase chain reaction (PCR) targeting ITSrDNA region followed by sequencing were conducted for typing the isolated parasite. A search for Leishmania virus infection was also performed. FINDINGS The mare presented skin nodules and ulcers in the left pinna caused by Leishmania spp. that was detected by culture and PCR. The parasite was identified as Leishmania (Mundinia) martiniquensis, infected by Leishbunyavirus (LBV), representing the first description of this species in South America. The animal travelled to different Brazilian regions, but not to outside the country. MAIN CONCLUSIONS The worldwide distribution of L. martiniquensis and its infection by LBV were confirmed in this study, indicating the autochthonous transmission cycle in Brazil. The clinical profile of the disease in the mare, showing fast spontaneous healing of cutaneous lesions, may indicate that skin lesions related to L. martiniquensis infection in horses might be underdiagnosed. scarce However braziliensis L Brazil, Brazil , (Brazil) PCR (PCR performed spp Mundinia (Mundinia LBV, (LBV) America country study underdiagnosed (Brazil (LBV

https://doi.org/10.1590/0074-02760220220

10.

Chikungunya virus infection in the southernmost state of Brazil was characterised by self-limited transmission (2017-2019) and a larger 2021 outbreak selflimited self limited 20172019 2017 2019 (2017-2019 202 2017201 201 (2017-201 20 201720 (2017-20 2 20172 (2017-2 (2017- (2017 (201 (20 (2 (
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Gregianini, Tatiana Schäffer

; Salvato, Richard Steiner

; Barcellos, Regina Bones

; Godinho, Fernanda Marques

; Ruivo, Amanda Pellenz

; de Melo, Viviane Horn

; Schroder, Júlio Augusto

; Martiny, Fernanda Letícia

; Möllmann, Erica Bortoli

; Favreto, Cátia

; Baethgen, Ludmila Fiorenzano

; Ferreira, Vithoria Pompermaier

; de Lima, Lívia Eidt

; Piazza, Cláudia Fasolo

; Machado, Taís Raquel Marcon

; Becker, Irina Marieta

; Ramos, Raquel Rocha

; Frölich, Guilherme Carey

; Rossetti, Alana Fraga

; Almeida, Lucas da Cunha

; Rodrigues, Tahiana Machado Antunes

; Bragança, Isabella Tabelli

; Campos, Aline Alves Scarpellini

; Manzoni, Verônica Baú

; Machado, Lais Ceschini

; da Silva, Luisa Maria Inácio

; de Oliveira, André Luiz Sá

; Paiva, Marcelo Henrique Santos

; Nunes, Zenaida Marion Alves

; de Almeida, Paula Rodrigues

; Demoliner, Meriane

; Gularte, Juliana Schons

; da Silva, Mariana Soares

; Filippi, Micheli

; Pereira, Vyctoria Malayhka de Abreu Góes

; Spilki, Fernando Rosado

; da Veiga, Ana Beatriz Gorini

; Wallau, Gabriel Luz

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220259

Resumo: En | Texto: En | PDF: En

BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk. mosquitoborne mosquito borne 2014 Brazil AsianCaribbean Asian Caribbean AC (AC EastCentralSouthAfrican East Central South African (ECSA states RS, , (RS) 2016 (CHIKF 20172021. 20172021 2017 2021. 2021 2017-2021 period 2020 limited Then lineage population 1 risk 201 (RS 2017202 202 2017-202 20 201720 2017-20 2 20172 2017-2 2017-

https://doi.org/10.1590/0074-02760220259

11.

Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report COVID19 COVID 19 COVID-1 XBB15 XBB 1 5 XBB.1. infection COVID1 COVID- XBB1 XBB.1 XBB.
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Espíndola, Otávio

; Resende, Paola C

; Guaraldo, Lusiele

; Calvet, Guilherme Amaral

; Fuller, Trevon L

; Penetra, Stephanie Lema Suarez

; Santos, Heloisa Ferreira Pinto

; Pina-Costa, Anielle

; da Silva, Michele Fernanda Borges

; Moraes, Isabella Campos Vargas

; Medeiros, Fernando

; Whitworth, Jimmy

; Smith, Christopher

; Nielsen-Saines, Karin

; Siqueira, Marilda M

; Brasil, Patrícia

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e230069

Resumo: En | Texto: En | PDF: En

BACKGROUND There is interest in lingering non-specific symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, referred to as Long coronavirus disease 2019 (Long COVID-19). It remains unknown whether the risk of Long COVID-19 is associated with pre-existing comorbidities or initial COVID-19 severity, including infections due to new Omicron lineages which predominated in 2023. OBJECTIVES The aim of this case report was to characterize the clinical features of acute XBB.1.5 infection followed by Long COVID-19. METHODS We followed a 73-year old female resident of Rio de Janeiro with laboratory-confirmed SARS-CoV-2 during acute infection and subsequent months. The SARS-CoV-2 lineage was determined by genome sequencing. FINDINGS The participant denied comorbidities and had completed a two-dose vaccination schedule followed by two booster doses eight months prior to SARS-CoV-2 infection. Primary infection by viral lineage XBB.1.5. was clinically mild, but the participant subsequently reported persistent fatigue. MAIN CONCLUSIONS This case demonstrates that Long COVID-19 may develop even after mild disease due to SARS-CoV-2 in fully vaccinated and boosted individuals without comorbidities. Continued monitoring of new SARS-CoV-2 lineages and associated clinical outcomes is warranted. Measures to prevent infection should continue to be implemented including development of new vaccines and antivirals effective against novel variants. nonspecific non specific SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 201 COVID19. COVID19 COVID 19 . COVID-19) COVID-1 preexisting pre existing severity 2023 XBB15 XBB 1 5 XBB.1. 19. 73year year 73 laboratoryconfirmed laboratory confirmed SARS-CoV- sequencing twodose dose fatigue warranted variants (SARS-CoV- 20 COVID1 COVID- 202 XBB1 XBB.1 7 SARS-CoV (SARS-CoV XBB.

https://doi.org/10.1590/0074-02760230069

12.

Intervención multidisciplinaria en pacientes con diabetes mellitus tipo 2 en comunidades rurales: un estudio piloto
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García-Flores, Raquel

; Campos-Rivera, Nora Hemi

; Sotelo-Quiñonez, Teresa Iveth

; Acosta-Quiroz, Christian Oswaldo

Horizonte sanitario

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Abr 2022, Volume 21 Nº 1 Páginas 43 - 50

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Objective: To evaluate the effects of a multidisciplinary intervention in patients with type 2 Diabetes Mellitus from rural communities. Materials and methods: Twenty-six patients (15 women and 11 men) with DM2 from two rural communities in northwestern Mexico participated. The average age was 60 years. The Beck Depression and Anxiety Inventory and Inventario de Calidad de Vida y Salud were applied, in addition to fasting glucose and glycosylated hemoglobin before and after the intervention. Results: Statistically significant pretest-postest changes were detected in depression and anxiety (p=.006 y p=.002 respectively). by Student's t for related samples and the size of the median and large effect by Cohen's d in the psychological variables. In fasting blood glucose changes were detected between the first and last sessions. However in glycosylated hemoglobin only 6 patients decreased their levels. Conclusions: Future studies involving community members to support the behavioral change of patients with DM2 are proposed.

Resumen Objetivo: Evaluar los efectos de una intervención multidisciplinaria, para mejorar la adhesión al tratamiento en diabetes mellitus tipo 2 (DM2) de comunidades rurales. Materiales y Métodos: Participaron 26 pacientes (15 mujeres) con DM2 (M edad = 60 DT = 12) de dos comunidades rurales del noroeste de México. Se aplicaron los inventarios de Depresión y Ansiedad de Beck y el Inventario de Calidad de Vida y Salud. Se midió la glucosa en el ayuno y la hemoglobina glicosilada antes y después de la intervención. Resultados: La intervención mostró una disminución en depresión y ansiedad, así como una mejor calidad de vida. También se detectó una disminución de la glucosa en ayuno. Se calculó la prueba t de Student para examinar las diferencias en las variables señaladas tomadas en dos momentos, antes de iniciar el programa y al finalizar el programa. Se observaron menores niveles de sintomatología depresiva, ansiedad y mayores niveles de calidad de vida al finalizar el programa. Además, el nivel de glucosa en sangre descendió de manera significativa. Conclusiones: Se analizaron las implicaciones de intervenciones de este tipo en comunidades rurales, detectándose la necesidad de implementar políticas públicas que permitan mejorar condiciones en población vulnerable.

https://doi.org/10.19136/hs.a21n1.3928

13.

Volviéndonos mejores: necesidad de acción inmediata ante el reto de la obesidad. Una postura de profesionales de la salud
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Barquera, Simón

; Véjar-Rentería, Lesly Samara

; Aguilar-Salinas, Carlos

; Garibay-Nieto, Nayely

; García-García, Eduardo

; Bonvecchio, Anabelle

; Perichart, Otilia

; Torres-Tamayo, Margarita

; Esquivias-Zavala, Héctor

; Villalpando-Carrión, Salvador

; García-Méndez, Rosalba Carolina

; Apolinar-Jiménez, Evelia

; Kaufer-Horwitz, Martha

; Martínez-Montañez, Olga Georgina

; Fajardo Niquete, Ileana

; Aguirre-Crespo, Alejandra

; Gómez-Álvarez, Enrique

; Hernández-Jiménez, Sergio C.

; Denova-Gutiérrez, Edgar

; Batis, Carolina

; Elías-López, Daniel

; Palos-Lucio, Ana Gabriela

; Vásquez-Garibay, Edgar M.

; Romero-Velarde, Enrique

; Ortiz-Rodríguez, María Araceli

; Almendra-Pegueros, Rafael

; Contreras, Alejandra

; Nieto, Claudia

; Hernández-Cordero, Sonia

; Munguía, Ana

; Rojas-Russell, Mario

; Sánchez-Escobedo, Samantha

; Delgado-Amézquita, Elvia

; Aranda-González, Irma

; Cruz-Casarrubias, Carlos

; Campos-Nonato, Ismael

; García-Espino, Fátima

; Martínez-Vázquez, Sophia

; Arellano-Gómez, Laura P.

; Caballero-Cantú, Idalia

; Hunot-Alexander, Claudia

; Valero-Morales, Isabel

; González-González, Lorena

; Ríos-Cortázar, Víctor

; Medina-García, Catalina

; Argumedo, Gabriela

; Calleja-Enríquez, Carmen Rosa

; Robles-Macías, Edna

; Nava-González, Edna J.

; Lara-Riegos, Julio

; Sánchez-Plascencia, Ana K.

; Hernández-Fernández, Mauricio

; Rodríguez-Núñez, Jose Luis

; Rangel-Quillo, Sarai

; Cancino-Marentes, Martha Edith

; Hernández-Viana, Mónica J.

; Saldivar-Frausto, Mariana

; Álvarez-Ramírez, Miriam

; Sandoval-Salazar, Cuauhtémoc

; Silva-Tinoco, Rubén Oswaldo

; Moreno-Villanueva, Mildred

; Villarreal-Arce, María Elena

; Barriguete, J. Armando

; White, Mariel

; Jauregui, Alejandra

; Tolentino-Mayo, Lizbeth

; López-Ridaura, Ruy

; Rivera-Dommarco, Juan

Salud Pública de México

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Abr 2022, Volume 64 Nº 2 Páginas 225 - 229

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract: In recent decades, the growing obesity epidemic in Mexico has become one of the most important public health challenges faced by the country. With support from the World Obesity Federation, we formed a working group in 2021 to identify and summarize priority actions that Mexico can take to face this epidemic. More than 1 000 health professionals joined the development and discussion process. Recommendations from previously published, high-level documents and guidelines were taken into account. In commemoration of World Obesity Day 2022, this statement is presented as input for health care professionals to develop actions to address obesity. The statement includes 10 recommendations that include population-level and individual-level actions. It emphasizes the importance of social participation, comprehensive interventions with a person- centered perspective, planetary sustainability, on improving education and communication campaigns, as well as fostering a built environment that promotes active living, and shielding prevention and control efforts from conflicts of interest. The statement calls for obesity to be treated seriously, based on scientific evidence, in a timely and comprehensive manner, employing a life-course and ethical approach that does not perpetuate weight stigma in society.

resumen está disponible en el texto completo

https://doi.org/10.21149/13679

14.

Fast surveillance response reveals the introduction of a new yellow fever virus sub-lineage in 2021, in Minas Gerais, Brazil
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Andrade, Miguel Souza

; Campos, Fabrício Souza

; Oliveira, Cirilo Henrique de

; Oliveira, Ramon Silva

; Campos, Aline Alves Scarpellini

; Almeida, Marco Antônio Barreto de

; Fonseca, Vagner de Souza

; Simonini-Teixeira, Danilo

; Sevá, Anaiá da Paixão

; Temponi, Andrea Oliveira Dias

; Magalhães, Fernando Maria

; Chaves, Danielle Costa Capistrano

; Pereira, Maira Alves

; Lamounier, Ludmila Oliveira

; Menezes, Givaldo Gomes de

; Aquino-Teixeira, Sandy Micaele

; Gonçalves-dos-Santos, Maria Eduarda

; Bernal-Valle, Sofía

; Müller, Nicolas Felipe Drumm

; Cardoso, Jader da Cruz

; Santos, Edmilson dos

; Mares-Guia, Maria Angélica

; Albuquerque, George Rêgo

; Romano, Alessandro Pecego Martins

; Franco, Ana Cláudia

; Ribeiro, Bergmann Morais

; Roehe, Paulo Michel

; Abreu, Filipe Vieira Santos de

Memórias do Instituto Oswaldo Cruz

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2022, Volume 117 elocation e220127

Resumo: En | Texto: En | PDF: En

BACKGROUND In Brazil, the yellow fever virus (YFV) is maintained in a sylvatic cycle involving wild mosquitoes and non-human primates (NHPs). The virus is endemic to the Amazon region; however, waves of epidemic expansion reaching other Brazilian states sporadically occur, eventually causing spillovers to humans. OBJECTIVES To report a surveillance effort that led to the first confirmation of YFV in NHPs in the state of Minas Gerais (MG), Southeast region, in 2021. METHODS A surveillance network was created, encompassing the technology of smartphone applications and coordinated actions of several research institutions and health services to monitor and investigate NHP epizootics. FINDINGS When alerts were spread through the network, samples from NHPs were collected and YFV infection confirmed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and genome sequencing at an interval of only 10 days. Near-complete genomes were generated using the Nanopore MinION sequencer. Phylogenetic analysis indicated that viral genomes were related to the South American genotype I, clustering with a genome detected in the Amazon region (state of Pará) in 2017, named YFVPA/MG sub-lineage. Fast YFV confirmation potentialised vaccination campaigns. MAIN CONCLUSIONS A new YFV introduction was detected in MG 6 years after the beginning of the major outbreak reported in the state (2015-2018). The YFV strain was not related to the sub-lineages previously reported in MG. No human cases have been reported, suggesting the importance of coordinated surveillance of NHPs using available technologies and supporting laboratories to ensure a quick response and implementation of contingency measures to avoid YFV spillover to humans.

https://doi.org/10.1590/0074-02760220127

15.

First report of Leishmania RNA virus 1 in Leishmania (Viannia) braziliensis clinical isolates from Rio de Janeiro State - Brazil
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Zabala-Peñafiel, Anabel

; Fantinatti, Maria

; Dias-Lopes, Geovane

; da Silva, Jéssica Leite

; Miranda, Luciana de Freitas Campos

; Lyra, Marcelo Rosandiski

; Pimentel, Maria Inês Fernandes

; Conceição-Silva, Fátima

; Alves, Carlos Roberto

Memórias do Instituto Oswaldo Cruz

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2022, Volume 117 elocation e210107

Resumo: En | Texto: En | PDF: En

BACKGROUND Leishmania parasites carry a double-stranded RNA virus (Leishmania RNA virus - LRV) that has been divided in LRV1 and LRV2. OBJECTIVES Leishmania (Viannia) braziliensis clinical isolates were assessed in order to determine LRV presence. METHODS Two-round polymerase chain reaction (PCR and nested PCR) was performed to detect LRV1 or LRV2 in L. (V.) braziliensis clinical isolates (n = 12). FINDINGS LRV1 was detected in three clinical isolates which was phylogenetically related to other sequences reported from other American tegumentary leishmaniasis (ATL) endemic areas of Brazil. Patients infected with L. (V.) braziliensis LRV-negative showed only cutaneous lesions while LRV-positive reported different manifestations. MAIN CONCLUSION Data presented here show for the first time that LRV1 is circulating in L. (V.) braziliensis clinical isolates from Rio de Janeiro State in Brazil.

https://doi.org/10.1590/0074-02760210107

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