RESUMO Este estudo tem como objetivo apresentar os resultados da tradução, validação transcultural e avaliação preliminar de uma ferramenta, originalmente desenvolvida no Reino Unido, para orientar pesquisadores brasileiros na elaboração de projetos e pesquisas de implementação rigorosos e de alta qualidade: ImpRes-BR. Seguindo boas práticas atualmente estabelecidas para validação transcultural de instrumentos e escalas, a ferramenta, juntamente com seu guia de utilização, foi traduzida e retrotraduzida, submetida a um teste piloto com 20 profissionais de saúde e avaliada por um painel de 10 especialistas que atribuíram os valores utilizados para os cálculos do Índice de Validade de Conteúdo ao nível do item (IVC-I) e escala (IVC-E). Nesse processo, além de índices de validade conceitual superiores à 90%, foi observado um IVC-I de pelo menos 0,90 em todos os domínios da ferramenta e seu guia e um IVC-E de 0,98. Estabelecida a validade da ferramenta e seu guia, a mesma foi aplicada em 14 projetos de pesquisa em fase de planejamento ou execução e foi reconhecida enquanto um instrumento potente para autoanálise das equipes na qualificação de seus projetos e fortalecimento destes em relação aos princípios da Ciência de Implementação. tradução Unido qualidade ImpResBR. ImpResBR ImpRes BR. BR ImpRes-BR escalas utilização retrotraduzida 2 1 IVCI IVC I (IVC-I IVCE. IVCE E . (IVC-E) processo 90 90% 090 0 0,9 098 98 0,98 Implementação (IVC-E 9 09 0,

ABSTRACT This study aims to present the results of the translation, cross-cultural validation and preliminary evaluation of a tool, originally developed in the United Kingdom, to guide Brazilian researchers in the elaboration of projects and rigorous and high-quality implementation research: ImpRes-BR. Following currently established good practices for cross-cultural validation of instruments and scales, the tool, together with its user guide, was translated and back-translated, subjected to a pilot test with 20 health professionals and evaluated by a panel of 10 specialists who assigned the values used for the calculations of the Content Validity Index at the item level (CVI-I) and scale (CVI-E). In this process, in addition to conceptual validity indices greater than 90%, an IVC-I of at least 0.90 was observed in all domains of the tool and its guide, and an IVC-E of 0.98. Having established the validity of the tool and its guide, it was applied in 14 research projects in the planning or execution phase and was recognized as a powerful instrument for self-analysis of the teams in the qualification of their projects and strengthening them in relation to the principles of the Implementation Science. translation crosscultural cross cultural Kingdom highquality high quality ImpResBR. ImpResBR ImpRes BR. BR ImpRes-BR scales backtranslated, backtranslated back translated, back-translated 2 1 CVII CVI I (CVI-I CVIE. CVIE E . (CVI-E) process 90 90% IVCI IVC 090 0 0.9 IVCE 098 98 0.98 selfanalysis self analysis Science (CVI-E 9 09 0.

ABSTRACT This study aims to present the results of the translation, cross-cultural validation and preliminary evaluation of a tool, originally developed in the United Kingdom, to guide Brazilian researchers in the elaboration of projects and rigorous and high-quality implementation research: ImpRes-BR. Following currently established good practices for cross-cultural validation of instruments and scales, the tool, together with its user guide, was translated and back-translated, subjected to a pilot test with 20 health professionals and evaluated by a panel of 10 specialists who assigned the values used for the calculations of the Content Validity Index at the item level (CVI-I) and scale (CVI-E). In this process, in addition to conceptual validity indices greater than 90%, an IVC-I of at least 0.90 was observed in all domains of the tool and its guide, and an IVC-E of 0.98. Having established the validity of the tool and its guide, it was applied in 14 research projects in the planning or execution phase and was recognized as a powerful instrument for self-analysis of the teams in the qualification of their projects and strengthening them in relation to the principles of the Implementation Science.

RESUMO Este estudo tem como objetivo apresentar os resultados da tradução, validação transcultural e avaliação preliminar de uma ferramenta, originalmente desenvolvida no Reino Unido, para orientar pesquisadores brasileiros na elaboração de projetos e pesquisas de implementação rigorosos e de alta qualidade: ImpRes-BR. Seguindo boas práticas atualmente estabelecidas para validação transcultural de instrumentos e escalas, a ferramenta, juntamente com seu guia de utilização, foi traduzida e retrotraduzida, submetida a um teste piloto com 20 profissionais de saúde e avaliada por um painel de 10 especialistas que atribuíram os valores utilizados para os cálculos do Índice de Validade de Conteúdo ao nível do item (IVC-I) e escala (IVC-E). Nesse processo, além de índices de validade conceitual superiores à 90%, foi observado um IVC-I de pelo menos 0,90 em todos os domínios da ferramenta e seu guia e um IVC-E de 0,98. Estabelecida a validade da ferramenta e seu guia, a mesma foi aplicada em 14 projetos de pesquisa em fase de planejamento ou execução e foi reconhecida enquanto um instrumento potente para autoanálise das equipes na qualificação de seus projetos e fortalecimento destes em relação aos princípios da Ciência de Implementação.

Abstract Neuregulins (NRGs) are a family of signaling proteins that bind to receptor tyrosine kinases of the ErbB family (ErbB2 to ErbB4), which can homo- or heterodimerize depending on their structural features and cell type. Many studies have proposed that decreased NRG levels are a common characteristic of obesity. In liver and adipose tissue, the increase in NRG expression has protective effects against obesity. However, it is still unknown whether ErbBs expression is altered in this pathology. We hypothesized that high fat diet-induced obesity downregulates ErbB receptors expression in obese mice compared to normal weight mice. Males C57BL/6 mice (n=6-7 for each group) were fed for 12 weeks and divided into: (i) control diet (CD; 10%-kcal fat, 20%-kcal protein, 70%-kcal carbohydrates), and (ii) high fat diet (HFD; 60%-kcal fat, 20%-kcal protein, 20%-kcal carbohydrates). General parameters and ErbBs expression (qPCR, immunohistochemistry and Western blot) were evaluated. We observed a significant increase in final body weight (47%), adipose tissue to body weight ratio (244%) and HOMA-IR (69%), among other parameters, in obese mice. In HFD group significantly decreased ErbB2 (48%) and ErbB3 (66%) mRNA levels in liver (no change in ErbB4), and ErbB2 (43%), ErbB3 (76%) and ErbB4 (35%) in adipose tissue, compared to CD. Furthermore, ErbB2 and ErbB3 protein levels decreased significantly in HFD group compared to the CD in liver. Therefore, our results suggest that HFD-induced obesity significantly decreases ErbBs expression in liver and adipose tissue in this murine model, that may be associated with alterations in the NRG pathway in obese mice.

Resumen Las neuregulinas (NRGs) son una familia de proteínas de señalización que se unen a receptores tirosina quinasas de la familia ErbB (ErbB2 a ErbB4), que pueden homo- o heterodimerizar dependiendo de sus características estructurales y del tipo celular. Estudios han propuesto que la disminución de los niveles de NRG es una característica común de la obesidad. En el hígado y el tejido adiposo (TA), el aumento de la expresión de NRG tiene efectos protectores contra la obesidad. Sin embargo, aún se desconoce si la expresión de ErbBs está alterada en esta patología. Nuestra hipótesis es que la obesidad inducida por una dieta alta en grasas (DAG) disminuye la expresión de los ErbB en ratones obesos. Ratones machos C57BL/6 (n=6-7 para c/grupo) fueron alimentados durante 12 semanas y divididos en: (i) dieta control (DC; 10%-kcal grasa, 20%-kcal proteína, 70%-kcal carbohidratos), y (ii) DAG (60%-kcal grasa, 20%-kcal proteína, 20%-kcal carbohidratos). Se evaluaron los parámetros generales y la expresión de ErbBs (qPCR, inmunohistoquímica y Western blot). Observamos un aumento significativo del peso corporal final (47%), de la relación tejido adiposo/peso corporal (244%) y del HOMA-IR (69%), entre otros parámetros, en ratones obesos. En este grupo disminuyó significativamente los niveles de ARNm de ErbB2 (48%) y ErbB3 (66%) en el hígado (sin cambios en ErbB4), y de ErbB2 (43%), ErbB3 (76%) y ErbB4 (35%) en el TA. Además, los niveles de proteína ErbB2 y ErbB3 disminuyeron significativamente, en comparación con el grupo DC en el hígado. Nuestros resultados sugieren que la obesidad inducida por DAG disminuye significativamente la expresión de ErbBs en el hígado y el TA, que puede estar asociado con alteraciones en la vía NRG en ratones obesos.

Resumen Objetivo Validar el contenido y la apariencia de un protocolo gráfico para la evaluación del cuidado seguro de enfermería a pacientes en hemodiálisis. Métodos Estudio metodológico con enfoque cuantitativo, organizado en tres procedimientos: teórico, a partir de una scoping review; empírico, donde se realizó el proceso de elaboración del protocolo gráfico y checklist para la evaluación del cuidado seguro; y por último, analítico, para la validación propiamente dicha mediante el uso del método Delphi y la participación de nueve jueces especialistas en dos rondas para alcanzar la concordancia. Resultados Se elaboró la checklist y el protocolo gráfico. Respecto a la validez del contenido, en Delphi I tres criterios obtuvieron Coeficiente de Validez de Contenido = 0,77 en la checklist. En lo referente al Delphi II, se alcanzó el 80 % en todos los ítems relacionados con el Coeficiente de Validez de Contenido, y todos los índices fueron superiores a 0,80. La validación de la apariencia se realizó con los criterios de la Suitability Assessment of Materials en Delphi I. Se logró alcanzar un Coeficiente de Validez de Contenido total mayor a 0,80 en todos, mientras que en Delphi II, los protocolos lograron una concordancia mayor a 80 % y Coeficiente de Validez de Contenido mayor a 0,88, ya que la checklist presentó mayor Coeficiente de Validez de Contenido con 0,91. Conclusión El protocolo gráfico y la checklist para la evaluación del cuidado seguro a pacientes en hemodiálisis demostraron ser válidos en su contenido y apariencia. cuantitativo procedimientos teórico review empírico último analítico 077 0 77 0,7 II 8 080 0,8 088 88 0,88 091 91 0,91 07 7 0, 08 09 9 0,9

Abstract Objective To validate the content and appearance of a graphic protocol for evaluating safe nursing care for hemodialysis patients. Methods Methodological study with a quantitative approach, organized into three procedures: theoretical from a Scoping Review; empirical in which the process of constructing the graphic protocol and checklist for the evaluation of safe care took place; finally, the analytics for the validation itself using the Delphi technique and the participation of nine expert judges in two rounds to reach agreement. Results The checklist and the graphic protocol were elaborated. As for content validity in Delphi I, three criteria obtained Content Validity Coefficient =0.77 in the checklist. In what corresponds to Delphi II, 80% was achieved in all items regarding the Content Validity Coefficient, all indices were above 0.80. Appearance validation took place using criteria of the Suitability Assessment of Materials in Delphi I, it was possible to achieve a total Content Validity Coefficient greater than 0.80 in all, while in Delphi II the protocols reached agreement greater than 80% and Content Validity Coefficient greater than 0.88, since the checklist showed a higher Content Validity Coefficient with 0.91. Conclusion The graphic protocol and checklist for evaluating safe care for hemodialysis patients are presented, valid in their content and appearance. approach procedures Review finally elaborated I 077 0 77 =0.7 80 080 0.8 088 88 0.88 091 91 0.91 presented 07 7 =0. 8 08 0. 09 9 0.9 =0 =

Resumo Objetivo Validar o conteúdo e a aparência de um protocolo gráfico para avaliação do cuidado seguro de enfermagem a pacientes em hemodiálise. Método Estudo metodológico com abordagem quantitativa, organizado em três procedimentos: teóricos, a partir de uma scoping review; empíricos, na qual ocorreu processo de construção do protocolo gráfico e checklist para avaliação do cuidado seguro; por fim, os analíticos, para a validação propriamente dita com uso da técnica Delphi e participação de nove juízes especialistas em duas rodadas para o alcance da concordância. Resultados Elaboraram-se o checklist e o protocolo gráfico. Quanto à validade de conteúdo, em Delphi I, três critérios obtiveram Coeficiente de Validade de Conteúdo =0,77 no checklist. No que corresponde ao Delphi II, foram alcançados 80% em todos os itens referentes ao Coeficiente de Validade de Conteúdo, e todos os índices ficaram acima de 0,80. A validação de aparência ocorreu utilizando critérios de Suitability Assessment of Materials no Delphi I. Foi possível atingir um Coeficiente de Validade de Conteúdo total maior que 0,80 em todos, enquanto que, no Delphi II, os protocolos alcançaram concordância maior que 80% e Coeficiente de Validade de Conteúdo maior que 0,88, já que o checklist apresentou maior Coeficiente de Validade de Conteúdo com 0,91. Conclusão Apresentam-se o protocolo gráfico e o checklist para avaliação do cuidado seguro aos pacientes em hemodiálise válidos em seu conteúdo e aparência. quantitativa procedimentos teóricos review empíricos fim analíticos Elaboraramse Elaboraram se I 077 0 77 =0,7 II 80 080 0,8 088 88 0,88 091 91 0,91 Apresentamse Apresentam 07 7 =0, 8 08 0, 09 9 0,9 =0 =

ABSTRACT Objective: To evaluate the efficacy and safety of sliding osteotomy of the lateral epicondyle in correcting rigid valgus deformity in knee arthroplasty. Methods: A retrospective study of patients undergoing total knee arthroplasty with lateral epicondyle sliding osteotomy between 2006 and 2018. The main outcome was the incidence of complications and adverse events. Secondary outcomes were Visual Analog Scale for Pain, varus stress test, and varus knee thrust during gait. Results: 19 knees (19 participants) were included in the study. The mean follow-up was 4.2 years. There were no cases of infection or reoperation due to instability. Two participants (10.5%) had mild or moderate knee pain (VAS pain = 4.6 ± 1.9). Two arthroplasties (10.5%) had mild varus stress. No participant presented varus thrust. Conclusion: Sliding osteotomy of the lateral epicondyle allows fast and safe ligament balance of knee valgus deformities. Level of Evidence I, Case series. Objective Methods 200 2018 events Pain test gait Results 1 (1 followup follow up 42 4 2 4. years instability 10.5% 105 10 5 (10.5% VAS 46 6 1.9. 1.9 . 9 1.9) Conclusion deformities I series 20 201 ( 10.5 (10.5 1. 10. (10. (10

RESUMO Avaliar a eficácia e a segurança da osteotomia de deslizamento do epicôndilo lateral na correção da deformidade em valgo rígida na artroplastia de joelho. Métodos: Estudo retrospectivo de pacientes submetidos à artroplastia total do joelho com osteotomia de deslizamento do epicôndilo lateral entre 2006 e 2018. O principal desfecho foi a incidência de complicações e eventos adversos. Os desfechos secundários foram escala visual analógica para dor, teste de estresse em varo e flambagem em varo do joelho durante a marcha. Resultados: Foram incluídos no estudo 19 joelhos (19 participantes). O seguimento médio foi de 4,2 anos. Não houve nenhum caso de infecção ou reoperação devido à instabilidade. Dois participantes (10,5%) apresentaram algum tipo de dor leve ou moderada no joelho (EVA = 4,6 ± 1,9). Duas artroplastias (10,5%) apresentaram estresse em varo leve. Nenhum participante apresentou flambagem em varo. Conclusão: A osteotomia de deslizamento do epicôndilo lateral possibilitou o balanço ligamentar das deformidades em valgo do joelho de forma rápida e segura. Nível de Evidência IV, Série de Casos. Métodos 200 2018 adversos marcha Resultados 1 (1 participantes. . participantes) 42 4 2 4, anos instabilidade 10,5% 105 10 5 (10,5% EVA 46 6 1,9. 1,9 9 1,9) Conclusão segura IV Casos 20 201 ( 10,5 (10,5 1, 10, (10, (10

ABSTRACT The objective of this study was to (i) use a combination of a definitive screening design (DSD) and a complete 33 factorial design to estimate the effects of four fertilizer supplements (factors) screened in the 1st planting cycle of Prata Gorutuba banana trees and (ii) determine whether combinations of these four factors can be identified for a future test. A DSD was combined with a complete 33 factorial scheme composed of three factors with three levels (application doses) each and three extra repetitions of the central level (commercial dose), totaling 30 experimental plots (27 + 3). The experimental area was divided into six blocks in a randomized block design (RBD) with 5 experimental plots each. The four selected factors included three soil conditioning products and a biostimulant based on seaweed extract. Experimental efficiency was maintained by performing a single trial with only 35.71% of the number of total plots used in the previous screening experiment. The results corroborated the main hypothesis of the study, i.e., that the most important factors previously screened in a previous trial could be maintained with three dose levels without altering the cultivation performance. i (i (DSD 3 (factors st ii (ii test application doses commercial dose, , dose) 27 (2 3. . 3) RBD (RBD extract 3571 35 71 35.71 experiment ie e i.e. performance 2 ( 357 7 35.7 i.e 35.

Abstract Background-Pulmonary arterial hypertension (PAH) increases afterload in the right ventricle (RV), inducing adverse ventricular remodelling. Objective- This study explored the protective effects of thyroid hormones and grape juice on serum biomarkers and proteins related to intermediary metabolism in the RV in a model of PAH. Methods- PAH was induced in Wistar rats via the administration of monocrotaline (60 mg/kg i.p.) and they were subsequently treated with organic grape juice (GJ) and thyroid hormones (TH), administered separately or in combination. Results: The RV systolic diameter significantly increased (20%) in the PAH group compared to the control group (P = 0.002). Total CK, LDH, and ALT levels were reduced (~50%) (P<0.001) in the PAH+TH+GJ group as compared to PAH group. Glucose, albumin, triglyceride, and total cholesterol levels were reduced (~50%) (P<0.001) in the PAH group; however, these parameters returned to baseline in the PAH+GJ group. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) protein expression increased two-fold (P<0.001) and PDH protein levels were reduced (~25%) in the PAH+TH+GJ group compared to the PAH group (P<0.001). Conclusion: The data suggest that serum biomarkers can help in the evaluation of this disease, and that this therapeutic approach can attenuate maladaptive remodelling in the PAH model. BackgroundPulmonary Background Pulmonary (PAH RV, , (RV) Objective Methods 60 (6 mgkg mg kg i.p. ip i p GJ (GJ TH, TH (TH) combination Results 20% 20 (20% P 0.002. 0002 0.002 . 0 002 0.002) CK LDH ~50% 50 (~50% P<0.001 P0001 001 (P<0.001 PAHTHGJ Glucose albumin triglyceride however PAHGJ proliferatoractivated proliferator activated 1alpha alpha 1 PGC1α PGCα PGC 1α α (PGC-1α twofold two fold ~25% 25 (~25% P<0.001. Conclusion disease (RV 6 ( i.p (TH 2 (20 000 0.00 00 ~50 5 (~50 P<0.00 P000 (P<0.00 ~25 (~25 (2 0.0 ~5 (~5 P<0.0 P00 (P<0.0 ~2 (~2 0. ~ (~ P<0. P0 (P<0. P<0 (P<0 P< (P<

Abstract Objectives: to analyze the trend and spatial distribution of hepatitis B in pregnant women in Brazil. Methods: ecological study based on all notified cases of hepatitis B in pregnant women through the Information System for Notifiable Diseases – Sinan between 2009 and 2018. Hepatitis B virus (HBV) detection rates were calculated in all municipalities. Spatial analysis was performed using the Global Moran Index for global data and local indicators of spatial association (Lisa) for the 5,570 municipalities. For trend analysis by State, the Prais-Winsten generalized linear regression model was used. Results: 15,253 pregnant women with HBV were reported. High detection rates were observed in the municipalities of São Miguel da Boa Vista-SC (68.96/1000 live births (LB)), Araguaiana-MT (68.18/1000 LB), Reserva do Cabaçal-MT (80, 00/1,000 LB), São Geraldo da Piedade-MG (75/1000 LB), Porto Mauá-RS (111, 11/1000 LB), in the respective bienniums. Moran (I) (I=0.056) showed a positive spatial association. In Lisa, 78 municipalities were included in the high-high cluster, 51.28% in the South region and 48 in the low-low cluster with 72.91% in the Southeast. There was an increasing trend in Maranhão (p=0.004) and Pernambuco (p=0.007) and a decrease in Mato Grosso (p=0.012), Paraná (p=0.031) and Santa Catarina (p=0.008). Conclusion: the detection of hepatitis B in pregnant women was observed in most Brazilian municipalities, with an increasing trend in two states and a decrease in three others. Objectives Brazil Methods 200 2018 (HBV Lisa (Lisa 5570 5 570 5,57 State PraisWinsten Prais Winsten used Results 15253 15 253 15,25 reported VistaSC Vista SC 68.96/1000 68961000 68 96 1000 (68.96/100 LB, LB , (LB)) AraguaianaMT Araguaiana MT 68.18/1000 68181000 18 (68.18/100 LB) CabaçalMT Cabaçal 80, 80 (80 001000 00 1 000 00/1,00 PiedadeMG Piedade MG 75/1000 751000 75 (75/100 MauáRS Mauá RS 111, 111 (111 111000 11 11/100 bienniums I (I I=0.056 I0056 0 056 (I=0.056 7 highhigh high 5128 51 28 51.28 4 lowlow low 7291 72 91 72.91 Southeast p=0.004 p0004 p 004 (p=0.004 p=0.007 p0007 007 (p=0.007 p=0.012, p0012 p=0.012 012 (p=0.012) p=0.031 p0031 031 (p=0.031 p=0.008. p0008 p=0.008 . 008 (p=0.008) Conclusion others 20 201 557 57 5,5 1525 25 15,2 68.96/100 6896100 6 9 100 (68.96/10 (LB) 68.18/100 6818100 (68.18/10 8 (8 00100 00/1,0 75/100 75100 (75/10 (11 11100 11/10 I=0.05 I005 05 (I=0.05 512 2 51.2 729 72.9 p=0.00 p000 (p=0.00 p001 p=0.01 01 (p=0.012 p=0.03 p003 03 (p=0.03 (p=0.008 55 5, 152 15, 68.96/10 689610 10 (68.96/1 (LB 68.18/10 681810 (68.18/1 ( 0010 00/1, 75/10 7510 (75/1 (1 1110 11/1 I=0.0 I00 (I=0.0 51. 72. p=0.0 p00 (p=0.0 (p=0.01 68.96/1 68961 (68.96/ 68.18/1 68181 (68.18/ 001 00/1 75/1 751 (75/ 11/ I=0. I0 (I=0. p=0. p0 (p=0. 68.96/ 6896 (68.96 68.18/ 6818 (68.18 00/ 75/ (75 I=0 (I=0 p=0 (p=0 68.96 689 (68.9 68.18 681 (68.1 (7 I= (I= p= (p= 68.9 (68. 68.1 (p 68. (68 (6

Resumo Objetivos: analisar a tendência e distribuição espacial da hepatite B em gestantes no Brasil. Métodos: estudo ecológico a partir de todos os casos notificados de hepatite B em gestantes pelo Sistema de Informação de Agravos de Notificação – Sinan entre 2009 e 2018. Foram calculadas as taxas de detecção do vírus da hepatite B (HBV) em todos os municípios. A análise espacial foi realizada por meio do Índice Global de Moran para os dados globais e os indicadores locais de associação espacial (Lisa) para os 5.570 municípios. Para análise de tendências por Estado, utilizou-se o modelo de regressão linear generalizada de Prais-Winsten. Resultados: foram notificadas 15.253 gestantes com HBV. Observou-se altas taxas de detecção nos municípios de São Miguel da Boa Vista-SC (68,96/1000 Nascidos vivos (NV)), Araguaiana-MT (68,18/1000 NV), Reserva do Cabaçal-MT(80,00/1.000 NV), São Geraldo da Piedade-MG (75/1000 NV), Porto Mauá-RS (111,11/1000 NV), nos respectivos biênios. Moran (I) (I=0,056) apresentou associação espacial positiva. No Lisa observou-se 78 municípios inserido no cluster alto-alto, sendo 51,28%na região Sul e 48 no cluster baixo-baixo com 72,91% no Sudeste. Verificou-se tendência crescente no Maranhão (p=0,004) e Pernambuco (p=0,007) e diminuição no Mato Grosso (p=0,012), Paraná (p=0,031) e Santa Catarina (p=0,008). Conclusão: Observou-se a detecção de hepatite B em gestantes na maioria dos municípios brasileiros, com tendência crescente em dois estados e diminuição em outros três. Objetivos Brasil Métodos 200 2018 HBV (HBV (Lisa 5570 5 570 5.57 Estado utilizouse utilizou se PraisWinsten. PraisWinsten Prais Winsten. Winsten Prais-Winsten Resultados 15253 15 253 15.25 Observouse Observou VistaSC Vista SC 68,96/1000 68961000 68 96 1000 (68,96/100 NV, NV , (NV)) AraguaianaMT Araguaiana MT 68,18/1000 68181000 18 (68,18/100 NV) CabaçalMT80,00/1.000 CabaçalMT80001000 CabaçalMT Cabaçal 80,00/1.000 80 00 1 000 Cabaçal-MT(80,00/1.00 PiedadeMG Piedade MG 75/1000 751000 75 (75/100 MauáRS Mauá RS 111,11/1000 111111000 111 11 (111,11/100 biênios I (I I=0,056 I0056 0 056 (I=0,056 positiva observouse observou 7 altoalto, altoalto alto alto, alto-alto 5128na 51 28 4 baixobaixo baixo 7291 72 91 72,91 Sudeste Verificouse Verificou p=0,004 p0004 p 004 (p=0,004 p=0,007 p0007 007 (p=0,007 p=0,012, p0012 p=0,012 012 (p=0,012) p=0,031 p0031 031 (p=0,031 p=0,008. p0008 p=0,008 . 008 (p=0,008) Conclusão brasileiros três 20 201 557 57 5.5 1525 25 15.2 68,96/100 6896100 6 9 100 (68,96/10 (NV) 68,18/100 6818100 (68,18/10 CabaçalMT80 CabaçalMT80,00/1.00 CabaçalMT8000100 80001000 80,00/1.00 8 Cabaçal-MT(80,00/1.0 75/100 75100 (75/10 111,11/100 11111100 (111,11/10 I=0,05 I005 05 (I=0,05 2 729 72,9 p=0,00 p000 (p=0,00 p001 p=0,01 01 (p=0,012 p=0,03 p003 03 (p=0,03 (p=0,008 55 5. 152 15. 68,96/10 689610 10 (68,96/1 (NV 68,18/10 681810 (68,18/1 CabaçalMT8 CabaçalMT80,00/1.0 CabaçalMT800010 8000100 80,00/1.0 Cabaçal-MT(80,00/1. 75/10 7510 (75/1 111,11/10 1111110 (111,11/1 I=0,0 I00 (I=0,0 72, p=0,0 p00 (p=0,0 (p=0,01 68,96/1 68961 (68,96/ 68,18/1 68181 (68,18/ CabaçalMT80,00/1. CabaçalMT80001 800010 80,00/1. Cabaçal-MT(80,00/1 75/1 751 (75/ 111,11/1 111111 (111,11/ I=0, I0 (I=0, p=0, p0 (p=0, 68,96/ 6896 (68,96 68,18/ 6818 (68,18 CabaçalMT80,00/1 CabaçalMT8000 80001 80,00/1 Cabaçal-MT(80,00/ 75/ (75 111,11/ 11111 (111,11 I=0 (I=0 p=0 (p=0 68,96 689 (68,9 68,18 681 (68,1 CabaçalMT80,00/ CabaçalMT800 8000 80,00/ Cabaçal-MT(80,00 (7 111,11 1111 (111,1 I= (I= p= (p= 68,9 (68, 68,1 CabaçalMT80,00 800 80,00 Cabaçal-MT(80,0 ( 111,1 (111, (p 68, (68 CabaçalMT80,0 80,0 Cabaçal-MT(80, 111, (111 (6 CabaçalMT80, 80, Cabaçal-MT(80 (11 Cabaçal-MT(8 (1 Cabaçal-MT( Cabaçal-MT

■ ABSTRACT Introduction: Reducing recurrence rates significantly, the use of biomaterials as “reinforcement meshes” in the repair of different abdominal wall defects has become an almost mandatory routine for the success of these repairs. From the 1990s onwards, acellular biological matrices were introduced, thus beginning a new era in the repair of abdominal wall defects. The objective is to evaluate the functionality of the acellularized bovine pericardium in abdominal wall repairs. Method: Thirty patients underwent repair of abdominal wall defects using acellular bovine pericardium bioprostheses, making a total of 40 anatomically individualized implants. The average follow-up was 31 months, with patients being evaluated clinically and radiologically. In three cases, biopsies were taken from the implanted areas, allowing histological analysis of the material. Results: No recurrence of herniations was observed in any of the cases, both clinically and radiologically. There were also no records of bruises, infections or any phenomenon of a local or systemic reaction nature. Radiologically, it was not possible to visualize the matrices at the implantation site in any of the postoperative periods analyzed. Conclusion: The matrices showed similarity to other biological membranes described in the international literature. Representing an important update and conceptual evolution, acellular bovine pericardial membranes can be incorporated into the therapeutic arsenal in abdominal wall repairs. Introduction significantly reinforcement meshes repairs s onwards introduced Method bioprostheses 4 implants followup follow up 3 months radiologically cases areas material Results bruises nature Radiologically analyzed Conclusion literature evolution

■ RESUMO Introdução: Reduzindo os índices de recidiva de forma impactante, o emprego de biomateriais como “telas de reforço” na reparação de diferentes defeitos da parede abdominal tornou-se rotina quase obrigatória para o sucesso dessas reparações. A partir da década de 1990 houve a introdução de matrizes biológicas acelulares, iniciando-se assim uma nova era na reparação dos defeitos da parede abdominal. O objetivo é avaliar a funcionalidade do pericárdio bovino acelularizado em reparações da parede abdominal. Método: Trinta pacientes foram submetidos a reparação de defeitos da parede abdominal, com biopróteses acelulares de pericárdio bovino, perfazendo um total de 40 implantes anatomicamente individualizados. O seguimento médio foi de 31 meses, sendo os pacientes avaliados clinicamente e radiologicamente. Em três casos foram feitas biópsias das áreas implantadas permitindo análise histológica do material. Resultados: Não se observou recidiva das herniações em nenhum dos casos, tanto clinica como radiologicamente. Também não houve registro de hematomas, infecções ou qualquer fenômeno de natureza reacional local ou sistêmica. Radiologicamente, não foi possível visualizar as matrizes no local de implantação em qualquer dos períodos de pós-operatório analisados. Conclusão: As matrizes mostraram similaridade às demais membranas biológicas descritas na literatura internacional. Representando uma importante atualização e evolução conceitual, as membranas acelulares de pericárdio bovino podem ser incorporadas ao arsenal terapêutico nas reparações de parede abdominal. Introdução impactante telas reforço tornouse tornou 199 iniciandose iniciando Método 4 individualizados 3 meses radiologicamente material Resultados hematomas sistêmica Radiologicamente pósoperatório pós operatório analisados Conclusão internacional conceitual 19 1

Abstract: In this article, part of a tribute series, I approach the intellectual trajectory of professor Marcia Contins and the dialogues we engaged in our research. From the motivations arising from these reflections on her trajectory and production, yet without exhausting the possibilities of nuance and the vast production on the topics, I seek to contextualise her work in a broader context of the debates around key topics of her research: religions (Afro-Brazilian, Pentecostalism and Popular Catholicism), race/ethnicity, the city. Our objective is to highlight the work of Professor Contins, who, throughout her career, presented relevant contributions, exploring the nuances and specificities of the topics under analysis, always sensitive to those that would later emerge and become of more general interest among other scholars. Abstract article series research AfroBrazilian, AfroBrazilian Afro Brazilian, Brazilian (Afro-Brazilian Catholicism, Catholicism , Catholicism) raceethnicity race ethnicity race/ethnicity city who career contributions analysis scholars

Resumo: Neste artigo, desenvolvido no âmbito de um ciclo de homenagens, abordo o percurso intelectual da professora Marcia Contins e os diálogos que estabelecemos em nossas pesquisas. A partir das motivações suscitadas pelas reflexões sobre sua trajetória e produção intelectual, sem esgotar as possibilidades de aprofundamentos e a vasta produção existente, busco contextualizar sua produção no quadro geral dos debates realizados sobre os principais temas que orientam suas pesquisas: religiões (afro-brasileiras, pentecostalismo e catolicismo popular), raça/etnicidade, cidade. O intuito é trazer à cena a produção da homenageada, que em sua carreira apresentou contribuições relevantes, explorando nuances e especificidades nos temas pesquisados, sempre sensível àqueles que emergiam e se tornariam focos de interesse mais geral de outros pesquisadores. Resumo artigo homenagens pesquisas existente afrobrasileiras, afrobrasileiras afro brasileiras, brasileiras (afro-brasileiras popular, popular , popular) raçaetnicidade raça etnicidade raça/etnicidade cidade homenageada relevantes pesquisados pesquisadores

SUMMARY BACKGROUND: Chemotherapy with doxorubicin may lead to left ventricular dysfunction. There is a controversial recommendation that biomarkers can predict ventricular dysfunction, which is one of the most feared manifestations of anthracycline cardiotoxicity. OBJECTIVE: The aim of this study was to evaluate the behavior of biomarkers such as Troponin I, type B natriuretic peptide, creatine phosphokinase fraction MB, and myoglobin in predicting cardiotoxicity in a cohort of women with breast cancer undergoing chemotherapy with anthracycline. METHODS: This is an observational, prospective, longitudinal, unicentric study, which included 40 women with breast cancer, whose therapeutic proposal included treatment with doxorubicin. The protocol had a clinical follow-up of 12 months. Biomarkers such as Troponin I, type B natriuretic peptide, creatine phosphokinase fraction MB, and myoglobin were measured pre-chemotherapy and after the first, third, fourth, and sixth cycles of chemotherapy. RESULTS: There was a progressive increase in type B natriuretic peptide and myoglobin values in all chemotherapy cycles. Although creatine phosphokinase fraction MB showed a sustained increase, this increase was not statistically significant. Troponin, type B natriuretic peptide, myoglobin, and creatine phosphokinase fraction MB were the cardiotoxicity markers with the earliest changes, with a significant increase after the first chemotherapy session. However, they were not able to predict cardiotoxicity. CONCLUSION: Troponin I, type B natriuretic peptide, myoglobin, and creatine phosphokinase fraction MB are elevated during chemotherapy with doxorubicin, but they were not able to predict cardiotoxicity according to established clinical and echocardiographic criteria. The incidence of subclinical cardiotoxicity resulting from the administration of doxorubicin was 12.5%. BACKGROUND dysfunction OBJECTIVE I METHODS observational prospective longitudinal 4 followup follow up 1 months prechemotherapy pre third fourth RESULTS changes session However CONCLUSION criteria 125 5 12.5% 12.5 12.

Abstract This study aimed to evaluate the phenophases of Cenostigma pyramidale (Tul.) Gagnon & G.P.Lewis in an area of Caatinga in the semi-arid region of Paraíba, Brazil. Field research was carried out in the municipality of Sumé, in the Experimental Space reserved for Studies on Ecology and Dynamics of the Caatinga - Area I of the Laboratory of Ecology and Botany - LAEB/CDSA/UFCG (7°39'38.8'' S and 36°53'42.4'' W; 538 m altitude). A total of 96 plots of 10 x 10 m were arranged in the study area, seeking to identify one specimen of C. pyramidale per plot. Monitoring was performed monthly from March 2019 to February 2020, recording budding, senescence, flower bud, flowering, and fruiting data. The Fournier intensity percentage and the activity index were analyzed. The highest budding intensity index was observed when there was a gradual increase in precipitation. Senescence had the highest peaks of intensity in the months with the absence or reduced levels of precipitation. Flower bud and flowering were practically equal throughout the monitoring period. The highest fruiting intensity occurred in the month with the highest precipitation. Regarding the budding activity index, all specimens expressed this phenophase as soon as the precipitation levels increased. In the dry period, all specimens showed senescence. Flower bud and flowering phenophases occurred synchronously. Fruiting had a higher activity index in periods of higher precipitation. Thus, it was observed that precipitation has a great influence on phenological events. Tul. Tul (Tul. GPLewis G P Lewis semiarid semi arid Paraíba Brazil Sumé LAEBCDSAUFCG LAEB CDSA UFCG 7°3938.8 739388 7°39 38.8 7 39 38 8 (7°39'38.8' 36°5342.4 3653424 36°53 42.4 36 53 42 4 36°53'42.4' W altitude. altitude . altitude) 9 1 C plot 201 2020 senescence data analyzed period increased synchronously Thus events (Tul 3938 7°3938. 73938 739 7°3 388 38. 3 (7°39'38.8 5342 36°5342. 365342 3653 36°5 424 42. 5 36°53'42.4 20 202 393 7°3938 7393 73 7° (7°39'38. 534 36°5342 36534 365 36° 36°53'42. 2 7°393 (7°39'38 36°534 36°53'42 (7°39'3 36°53'4 (7°39' 36°53' (7°39 (7°3 (7° (7 (

ABSTRACT INTRODUCTION Lung cancer (LC) is a relevant public health problem in Brazil and worldwide, given its high incidence and mortality. Thus, the objective of this study is to analyze the distribution of smoking and smoking status according to sociodemographic characteristics and disparities in access, treatment, and mortality due to LC in Brazil in 2013 and 2019. METHOD Retrospective study of triangulation of national data sources: a) analysis of the distribution of smoking, based on the National Survey of Health (PNS); b) investigation of LC records via Hospital-based Cancer Registry (HCR); and c) distribution of mortality due to LC in the Mortality Information System (SIM). RESULTS There was a decrease in the percentage of people who had never smoked from 2013 (68.5%) to 2019 (60.2%) and in smoking history (pack-years). This was observed to be greater in men, people of older age groups, and those with less education. Concerning patients registered in the HCR, entry into the healthcare service occurs at the age of 50, and only 19% have never smoked. While smokers in the population are mainly Mixed-race, patients in the HCR are primarily White. As for the initial stage (I and II), it is more common in White people and people who have never smoked. The mortality rate varied from 1.00 for people with higher education to 3.36 for people without education. Furthermore, White people have a mortality rate three times higher than that of Black and mixed-race people. CONCLUSION This article highlighted relevant sociodemographic disparities in access to LC diagnosis, treatment, and mortality. Therefore, the recommendation is to strengthen the Population-Based Cancer Registry and develop and implement a nationwide LC screening strategy in Brazil since combined prevention and early diagnosis strategies work better in controlling mortality from the disease and continued investment in tobacco prevention and control policies. (LC worldwide Thus treatment 201 sources PNS (PNS) b Hospitalbased Hospital (HCR) c SIM. SIM . (SIM) 68.5% 685 68 5 (68.5% 60.2% 602 60 2 (60.2% packyears. packyears pack years (pack-years) men groups 50 19 Mixedrace, Mixedrace Mixed race, race Mixed-race I II, II , II) 100 1 00 1.0 336 3 36 3.3 Furthermore mixedrace mixed Therefore PopulationBased Population Based policies 20 (PNS (HCR (SIM 68.5 6 (68.5 60.2 (60.2 (pack-years 10 0 1. 33 3. 68. (68. 60. (60. (68 (60 (6 (

RESUMO INTRODUÇÃO O câncer de pulmão (CP) é um relevante problema de saúde pública no Brasil e no mundo, dada sua alta incidência e mortalidade. Assim, objetiva-se analisar a distribuição do tabagismo e da carga tabágica segundo características sociodemográficas e disparidades no acesso, no tratamento e na mortalidade por CP no Brasil, em 2013 e 2019. MÉTODO Estudo retrospectivo de triangulação de fontes de dados de abrangência nacional: a) análise da distribuição do tabagismo, baseada na Pesquisa Nacional de Saúde (PNS); b) investigação dos registros de CP, via Registros Hospitalares de Câncer (RHC); e c) distribuição da mortalidade por CP, no Sistema de Informação sobre Mortalidade (SIM). RESULTADOS Verificou-se redução do percentual de pessoas que nunca fumaram de 2013 (68,5%) para 2019 (60,2%), assim como da carga tabágica (anos-maço). Esta foi observada maior em homens em pessoas de faixas etárias mais avançadas e de menor escolaridade. Em relação aos pacientes registrados no RHC, a entrada no serviço de saúde se dá a partir de 50 anos, e apenas 19% nunca fumaram. Ao passo que os fumantes na população são majoritariamente pardos, os pacientes no RHC são em maioria brancos. Quanto ao estadiamento inicial (I e II), é mais frequente em pessoas brancas e que nunca fumaram. A taxa de mortalidade apresentou variação de 1,00, para pessoas com ensino superior, a 3,36, entre pessoas sem instrução, assim como pessoas brancas têm uma taxa de mortalidade três vezes maior que a de pessoas negras e pardas. CONCLUSÃO Este artigo apontou relevantes disparidades sociodemográficas no acesso ao diagnóstico, tratamento e mortalidade do CP. Assim, recomenda-se: fortalecer o Registro de Câncer de Base Populacional; desenvolver e implementar estratégia de screening de CP no Brasil, uma vez que a realização de estratégias de prevenção e diagnóstico precoce combinadas funcionam melhor no controle da mortalidade pela doença; e investimento contínuo nas políticas de prevenção e controle do tabagismo. (CP mundo Assim objetivase objetiva 201 nacional PNS (PNS) b (RHC) c SIM. SIM . (SIM) Verificouse Verificou 68,5% 685 68 5 (68,5% 60,2%, 602 60,2% , 60 2 (60,2%) anosmaço. anosmaço anos maço (anos-maço) escolaridade 19 pardos brancos I II, II II) 100 1 00 1,00 superior 336 3 36 3,36 instrução pardas recomendase recomenda recomenda-se Populacional doença 20 (PNS (RHC (SIM 68,5 6 (68,5 60,2 (60,2% (anos-maço 10 0 1,0 33 3,3 68, (68, 60, (60,2 1, 3, (68 (60, (6 (60 (

ABSTRACT Objective This study aimed to provide a long-term follow-up of PRKAG2 syndrome and describe the new phenotypic aspects of the condition. PRKAG2 syndrome is a rare autosomal-dominant glycogen storage disease characterized by cardiac hypertrophy, ventricular pre-excitation, and conduction system disease. Fatal arrhythmias occur frequently. Methods A family cohort of 66 participants was recruited. Clinical and genetic analyses were performed. Results Median age of 36.97±17.28 years, with 69.9% being men. Nineteen subjects carried the deleterious variant p.K290I of the PRKAG2 gene. This group experienced many malignant events, including eight pacemaker implants, three sudden cardiac deaths, five aborted cardiac arrests, four strokes, four premature neonatal deaths, two spontaneous abortions, five forceps deliveries, and 12 cesarean procedures. Extracardiac involvement, such as in neurocognitive and psychiatric disorders, has been observed only in carriers of mutations. Palpitations, Syncope, atrial fibrillation, atrial flutter, sinus pauses, and bradycardia were strongly and significantly associated with major or severe adverse events (sudden cardiac death, aborted cardiac arrest, pacemaker use, stroke, and congestive heart failure). Early diagnosis and intervention through antiarrhythmic drugs, anticoagulation, pacemaker implantation, radiofrequency catheter ablation, and cesarean section surgery improved the symptoms and survival rates. Mutations carriers were advised to avoid pregnancy. Conclusion This study identified that the p.K291I_PRKAG2 mutation is associated with poor prognosis, highlighting the need for early intervention. Further research may uncover the potential connections between intellectual disability, miscarriage, and neonatal death in individuals with this syndrome. longterm long term followup follow up PRKAG condition autosomaldominant autosomal dominant hypertrophy preexcitation, preexcitation pre excitation, excitation pre-excitation frequently 6 recruited performed 36971728 36 97 17 28 36.97±17.2 years 699 69 9 69.9 men pK290I pKI p K290I K I gene implants deaths arrests strokes abortions deliveries 1 procedures involvement disorders mutations Palpitations Syncope fibrillation flutter pauses arrest use stroke failure. failure . failure) drugs anticoagulation implantation ablation rates pregnancy pK291IPRKAG2 pKIPRKAG K291I p.K291I_PRKAG prognosis disability miscarriage 3697172 3 2 36.97±17. 69. pK KI IPRKAG pK291IPRKAG 369717 36.97±17 36971 36.97±1 3697 36.97± 369 36.97 36.9 36.

ABSTRACT This article aims to present the results of the Niterói Bicycle Policy Evaluability study. It is a pre-evaluative approach whose methodological path adopted the following steps: i) Document analysis; ii) Construction of the theoretical-logical model; iii) Agreement on the model with interested actors; iv) Definition of evaluative questions. The study made it possible to present a feasible, measurable and realistic design of the policy with the following dimensions: Urban Mobility, Safety and Cycle Education, Accountability and Healthy and Sustainable City. The importance of spreading monitoring and evaluation actions is reinforced here as an essential movement to strengthen the cyclomobility policy as an alternative transport and health promoter. preevaluative pre steps i analysis ii theoreticallogical theoretical logical iii actors iv questions feasible dimensions Mobility Education City promoter

RESUMEN Este artículo tiene como objetivo presentar los resultados del estudio de Evaluabilidad de la Política de Bicicletas de Niterói. Se trata de un enfoque preevaluativo cuyo recorrido metodológico adoptó los siguientes pasos: i) Análisis de documentos; ii) Construcción del modelo teórico-lógico; iii) Acuerdo sobre el modelo con los actores interesados; iv) Definición de preguntas evaluativas. El estudio permitió presentar un diseño factible, medible y realista de la política con las siguientes dimensiones: Movilidad Urbana, Seguridad y Educación Ciclista, Rendición de Cuentas y Ciudad Saludable y Sostenible. Se refuerza aquí la importancia de difundir acciones de seguimiento y evaluación como un movimiento imprescindible para fortalecer la política de ciclomovilidad como transporte alternativo y promotor de la salud. Niterói pasos i documentos ii teóricológico teórico lógico teórico-lógico iii interesados iv evaluativas factible dimensiones Urbana Ciclista Sostenible salud

RESUMO Esse artigo tem como objetivo apresentar os resultados do estudo de Avaliabilidade da Política Niterói de Bicicleta. Trata-se de uma abordagem pré-avaliativa cujo caminho metodológico adotou como etapas: i) Análise documental; ii) Construção do modelo teórico-lógico; iii) Pactuação do modelo com os atores interessados; iv) Definição das perguntas avaliativas. O estudo permitiu apresentar um desenho factível, mensurável e realista da política com as seguintes dimensões: Mobilidade Urbana, Segurança e Educação Cicloviária, Accountability e Cidade Saudável e Sustentável. Reforça-se aqui a importância de capilarizar ações de monitoramento e avaliação como um movimento indispensável ao fortalecimento da política de ciclomobilidade como transporte alternativo e promotor da saúde. Bicicleta Tratase Trata se préavaliativa pré avaliativa etapas i documental ii teóricológico teórico lógico teórico-lógico iii interessados iv avaliativas factível dimensões Urbana Cicloviária Sustentável Reforçase Reforça saúde