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Safety of two-dose schedule of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan) and heterologous additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised and immunocompetent individuals
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Miyaji, Karina Takesaki

; Ibrahim, Karim Yaqub

; Infante, Vanessa

; Moreira, Raquel Megale

; Santos, Carolina Ferreira dos Belizário, Juliana de Cássia Pinto, Maria Isabel de Moraes Marinho, Ana Karolina Barreto Berselli Pereira, Juliana Marquezi Mello, Liliane Saraiva de Silva, Vitor Gabriel Lopes da Sato, Paula Keiko Strabelli, Tânia Mara Varejão Ragiotto, Lucas Pacheco, Pedro Henrique Theotonio de Mesquita Braga, Patricia Emilia Loch, Ana Paula Precioso, Alexander Roberto Sartori, Ana Marli Christovam França, João Ítalo Lima, Marcos Alves de Ando, Mauricio Cesar Sampaio Rodrigues, Camila Cristina Martini Song, Alice Tung Wan Lara, Amanda Nazareth Belizário, Ana Cristina Lima, Anna Helena Simões Bortulucci de Zanetti, Ariane Cristina Barboza Paulo, Audrey Rose da Silveira Amancio de Rosa, Barbara Miranda dos Santos Moraes, Bruna Del Guerra de Carvalho Oliveira, Bruna Ribeiro de Picone, Camila de Melo Aranda, Carolina Sanches Troli, Carolinne Paioli Kokron, Cristina M. Terrabuio, Debora Raquel Benedita Abdala, Edson David Neto, Elias Nakanishi, Érika Yoshie Shimoda Lima, Fabiana Mascarenhas Souza Firmino, Fabio Batista Santos, Fernanda Barone Alves dos Bacal, Fernando Fatobene, Giancarlo Santana, Jaqueline Oliveira Kalil, Jorge Barbosa, Julia Gonçalves, Leandro Peres Otuyama, Leonardo Jun Pierrotti, Ligia Camera Compte, Livia Caroline Mariano Marinho, Livia Chaer, Livia Netto Seguro, Luis Fernando Azevedo, Luiz Sergio Ueda, Márcia Aiko Terreri, Maria Teresa Barros, Myrthes Anna Maragna Toledo Grecco, Octávio Sejas, Odeli Nicole Encinas Musqueira, Priscila Tavares Ito, Raquel Keiko de Luca Teixeira, Samia Silveira Souza Fidalgo, Serafim Costa, Silvia Figueiredo Campos, Silvia Vidal Fernandes, Tamiris Hinsching Rocha, Vanderson Geraldo Coelho, Vivian Caso

Revista do Instituto de Medicina Tropical de São Paulo

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2025, Volume 67 elocation e2

Resumo: En | Texto: En | PDF: En

ABSTRACT Immunocompromised individuals were considered high-risk for severe disease due to SARS COV-2 infection. This study aimed to describe the safety of two doses of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan), followed by additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised (IC) adults, compared to immunocompetent/healthy (H) individuals. This phase 4, multicenter, open label study included solid organ transplant and hematopoietic stem cell transplant recipients, cancer patients and people with inborn errors of immunity with defects in antibody production, rheumatic, end-stage chronic kidney or liver disease, who were enrolled in the IC group. Participants received two doses of CoronaVac and additional doses of mRNA BNT162b2. Adverse reactions (AR) data were collected within seven days after each vaccination. Serious adverse events and of special interest (AESI) were monitored throughout the study. We included 241 immunocompromised and 100 immunocompetent subjects. Arthralgia, fatigue, myalgia, and nausea were more frequent in the IC group after CoronaVac. Following the first additional dose of mRNA BNT162, pain, induration, and tenderness at injection site, fatigue and myalgia were more frequent in the H group. A heart transplant recipient had a graft rejection temporally associated with the second CoronaVac dose, but there was no literature evidence of causal association. Four cases of AESI were considered related to the vaccine: three erythema multiforme after CoronaVac, all in IC participants, and one paresthesia after mRNA, in a H participant. Our findings were comparable to other studies that evaluated the safety of COVID-19 vaccines in different immunocompromised populations. Both vaccines were safe for immunocompromised participants.

https://doi.org/10.1590/s1678-9946202567002

Saturated hydraulic conductivity and steady-state infiltration rate database for Brazilian soils
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Ottoni, Marta Vasconcelos

; Teixeira, Wenceslau Geraldes

; Reis, Aline Mari Huf dos

; Pimentel, Letícia Guimarães

; Souza, Luciana Rodrigues

; Albuquerque, Jackson Adriano

; Melo, Valdinar Ferreira

; Cavalieri-Polizeli, Karina Maria Vieira

; Reichert, José Miguel

; Viana, João Herbert Moreira

; Fontana, Ademir

; Medrado, Lucas de Castro

; Santos, Glenio Guimarães

; Amaral, Luís Gustavo Henriques do

; Anjos, Lúcia Helena Cunha dos

; Araújo Filho, José Coelho de

; Bhering, Silvio Barge

; Brito, Gabrielle Fernandes de

; Valle, Pedro Gomes de Campos do

; Campos, Pablo Nieto

; Costa, Adriana Monteiro da

; Marques, Jean Dalmo de Oliveira

; Martins, Alba Leonor da Silva

; Nascimento, Michele Bruna de Souza do

; Noronha, Norberto Cornejo

; Oliveira, Ricardo Duarte de

; Portela, Jeane Cruz

; Serafim, Milson Evaldo

; Silva, Marlen Barros e

; Rodrigues, Sueli

; Almeida, Wilk Sampaio de

; Moraes, Margareth Lopes de

; Curi, Nilton

Revista Brasileira de Ciência do Solo

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2025, Volume 49 elocation e0240003

Resumo: En | Texto: En | PDF: En

ABSTRACT Soil saturated hydraulic conductivity (Ksat) and steady-state infiltration rate (SSIR) are essential and necessary soil properties for different geoscience applications. Values of these hydraulic properties for the Brazilian territory are difficult to access and are dispersed in research efforts carried out around the country. This study developed an easy-to-manipulate, freely accessible database of soil saturated hydraulic conductivity, comprising field and laboratory analyses, and steady-state infiltration rates for Brazilian soils. This database was named Ksat-SSIR-DB. One analysis of the Ksat-SSIR-DB aimed to evaluate its coverage in Brazilian territory and in different soil groups. Average values of these hydraulic properties were also presented for textural classes, with values compared to those reported in international literature, and for other groupings, such as soil class, land use class, and porosity class. The variability of Ksat data in these groupings and in their combinations were also analyzed. The Ksat-SSIR-DB showed broad national coverage, comprising a total of 2,579 records, corresponding to 409 sampling sites, with Ksat and/or SSIR data and other associated soil information. A significant difference was observed between Ksat values for the vast majority of Brazilian clayey and very clayey soils compared to soils from the same textural groups from temperate regions. The two groupings that presented the lowest variability in terms of Ksat standard deviation values were the combination of textural classes with soil classes at the second category level of SiBCS (Brazilian Soil Classification System), and porosity classes with soil classes at the second category level of SiBCS. The Ksat-SSIR-DB has enormous potential for developing and testing Ksat pedotransfer functions in Brazilian soils, serving as a reference source for different geoenvironmental applications and, in particular, for modeling land surface processes. It is open access and can be accessed at https://www.sgb.gov.br/ksat-ssir-dbbase-de-dados-de-condutividade-hidraulica-saturada-e-de-taxa-de-infiltracao-basica-emsolos-brasileiros, which also includes the python script for data analysis.

https://doi.org/10.36783/18069657rbcs20240003

Evidências de validade da Depression, Anxiety and Stress Scale entre trabalhadores de enfermagem brasileiros
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Oliveira, Samuel Andrade de

; Santin Júnior, Lacir José

; Fracarolli, Isabela Fernanda Larios

; Martins, Bianca Gonzalez

; Campos, Juliana Alvares Duarte Bonini

; Marziale, Maria Helena Palucci

; Deodato, Sergio Joaquim

; Rocha, Fernanda Ludmilla Rossi

Acta Paulista de Enfermagem

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2025, Volume 38 elocation eAPE0003261

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo Investigar as evidências de validade da Depression, Anxiety and Stress Scale (DASS-21) para análise da prevalência de sintomas de depressão, ansiedade e estresse em uma amostra de trabalhadores de enfermagem brasileiros. Métodos Estudo transversal, com amostragem não-probabilística. Participaram do estudo 4053 trabalhadores de enfermagem brasileiros. As propriedades psicométricas da DASS-21 foram avaliadas por meio de análise da validade baseada na estrutura interna (validade de construto fatorial, convergente e discriminante; invariância do modelo fatorial; confiabilidade); validade baseada nas relações com medidas externas (validade convergente positiva e negativa dos fatores depressão, ansiedade e estresse com os construtos prejuízo emocional, satisfação no trabalho e variáveis individuais e ocupacionais); validade baseada no padrão de resposta aos itens do instrumento (análise da função diferencial dos itens em subgrupos distintos). A confiabilidade dos dados foi atestada por meio da estimação do coeficiente alfa ordinal e da confiabilidade composta. A prevalência de sintomas de depressão, ansiedade e estresse foi estimada a partir das recomendações dos autores originais da DASS-21. Resultados Durante a validação da estrutura interna, a análise fatorial confirmatória revelou que o modelo original da DASS-21 apresentou ajustamento adequado para a amostra e foi atestada a invariância de medida forte do modelo entre grupos distintos. A análise baseada em medidas externas mostrou que os fatores depressão, ansiedade e estresse apresentaram correlações positivas e moderadas-fortes com o domínio prejuízo emocional e correlações negativas e moderadas com o construto satisfação no trabalho. A análise do padrão de repostas aos itens comprovou a uniformidade e a estabilidade do instrumento para a amostra. Quanto aos sintomas, destaca-se a alta prevalência de níveis extremamente graves de depressão, ansiedade e estresse entre os participantes. Conclusão A DASS-21 apresentou adequada validade e confiabilidade para a avaliação de sintomas de depressão, ansiedade e estresse entre trabalhadores de enfermagem brasileiros.

Abstract Objectives To investigate the validity evidence of the Depression, Anxiety, and Stress Scale (DASS-21) and to analyze the prevalence of depression, anxiety, and stress symptoms in a sample of Brazilian nursing workers. Methods This was a cross-sectional study with non-probability convenience sampling. A total of 4053 Brazilian nursing workers participated in the study. The psychometric properties of DASS-21 were assessed by analysis of the validity based on the internal structure (factorial, convergent, and discriminant construct validity, invariance of the factorial model, and reliability); relationships with external measures (positive and negative convergent validity of the depression, anxiety, and stress factors with the emotional impairment, job satisfaction, and individual and occupational variables); and response process of the items (analysis of the differential item functioning in distinct subgroups). Data reliability was certified by estimating the ordinal alpha coefficient and the composite reliability. The prevalence of depression, anxiety, and stress symptoms was estimated based on recommendations from the original authors of DASS-21. Results During validation of the internal structure, the confirmatory factor analysis showed that the fit of the sample to the original DASS-21 model was adequate and the strong measurement invariance of the model was confirmed in different groups. Analysis based on external measures showed that the depression, anxiety, and stress factors had positive and moderate-strong correlations with the emotional impairment domain and negative and moderate correlations with the job satisfaction construct. Analysis of the pattern of response to items confirmed the uniformity and stability of the instrument for the sample. Regarding symptoms, the high prevalence of extremely severe levels of depression, anxiety, and stress was highlighted among participants. Conclusion DASS-21 presented adequate validity and reliability to assess depression, anxiety, and stress symptoms among Brazilian nursing workers.

Resumen Objetivo Investigar las evidencias de validez de la Depression, Anxiety and Stress Scale (DASS-21) para analizar la prevalencia de síntomas de depresión, ansiedad y estrés en una muestra de trabajadores de enfermería brasileños. Métodos Estudio transversal con muestreo no probabilístico. Participaron en el estudio 4053 trabajadores de enfermería brasileños. Se evaluaron las propiedades psicométricas de la DASS-21 mediante el análisis de validez basada en le estructura interna (validez del constructo factorial, convergente y discriminante; invarianza del modelo factorial; fiabilidad), validez basada en las relaciones con medidas externas (validez convergente positiva y negativa de los factores depresión, ansiedad y estrés con los constructos daño emocional, satisfacción en el trabajo y variables individuales y laborales), validez basada en el patrón de respuesta a los ítems del instrumento (análisis de la función diferencial de los ítems en subgrupos distintos). Se comprobó la fiabilidad de los datos mediante la estimación del coeficiente alfa ordinal y la fiabilidad compuesta. La prevalencia de síntomas de depresión, ansiedad y estrés se estimó a partir de las recomendaciones de los autores originales de la DASS-21. Resultados Durante la validación de la estructura interna, el análisis factorial confirmatorio reveló que el modelo original de la DASS-21 presentó un ajuste adecuado para la muestra y se comprobó la invarianza de medida fuerte del modelo entre grupos distintos. El análisis basado en las medidas externas mostró que los factores depresión, ansiedad y estrés presentan correlaciones positivas y moderadas-fuertes con el dominio daño emocional y correlaciones negativas y moderadas con el constructo satisfacción en el trabajo. El análisis del patrón de respuestas de los ítems comprobó la uniformidad y la estabilidad del instrumento para la muestra. Respecto a los síntomas, se destaca la alta prevalencia de niveles extremadamente graves de depresión, ansiedad y estrés entre los participantes. Conclusión La DASS-21 presentó validez y fiabilidad adecuada para evaluar síntomas de depresión, ansiedad y estrés entre trabajadores de enfermería brasileños.

https://doi.org/10.37689/acta-ape/2025ao0003261

Evidências de validade da Depression, Anxiety and Stress Scale entre trabalhadores de enfermagem brasileiros Depression
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Oliveira, Samuel Andrade de

; Santin Júnior, Lacir José

; Fracarolli, Isabela Fernanda Larios

; Martins, Bianca Gonzalez

; Campos, Juliana Alvares Duarte Bonini

; Marziale, Maria Helena Palucci

; Deodato, Sergio Joaquim

; Rocha, Fernanda Ludmilla Rossi

Acta Paulista de Enfermagem

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2025, Volume 38 elocation eAPE0003261

Resumo: Pt Es En | Texto: Pt Es En | PDF: Pt | PDF: Es | PDF: En

https://doi.org/10.37689/acta-ape/2025ao0003261

Consensus of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy (ABHH) and the Brazilian Ministry of Health - General management of blood and blood products on the tests necessary for the release of exceptional medicines for sickle cell disease Hematology ABHH (ABHH
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Lobo, Clarisse

; Araújo, Aderson Antunes, Alexandre de Albuquerque Pinto, Ana Cristina Silva Godinho, Ariadne Carvalho Pires, Cassia Silvestre Mariano Matheus, Cinthia Cristina Albuquerque, Xerez de Neves, Daniele Campos Fontes Moreno, Fábio de Lima Baldanzi, Giorgio Siufi, Grazziella Curado Miranda, Heloisa Helena Pereira Hankins, Jane Aragão, Joice Braga, Josefina Aparecida Pellegrini Martins, Juliana Touguinha Neves Souza, Luciana Campos Costa Machado de Figueiredo, Maria Stella Oliveira, Mirella Rodrigues Cardoso, Patricia Santos Resende Pinto, Patricia Costa Alves Moura, Patricia Gomes Cançado, Rodolfo Delfini Araujo, Paulo Ivo Cortez de Saad, Sara Olalla Loggetto, Sandra Regina Fonseca, Teresa Cristina Cardoso

Hematology, Transfusion and Cell Therapy

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Mar 2024, Volume 46 Nº 1 Páginas 67 - 71

Resumo: En | Texto: En | PDF: En

Abstract To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety. date disease reallife real life attacks vasoocclusive vaso occlusive events syndrome transfusion which part physicians physician s report safety

https://doi.org/10.1016/j.htct.2024.01.001

Diretriz Brasileira sobre a Saúde Cardiovascular no Climatério e na Menopausa – 2024 202 20 2
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Oliveira, Gláucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Arcelus, Carolina María Artucio

; Neto Espíndola, Larissa

; Rivera, Maria Alayde Mendonça

; Silva-Filho, Agnaldo Lopes da

; Marques-Santos, Celi

; Fernandes, César Eduardo

; Albuquerque, Carlos Japhet da Matta

; Freire, Claudia Maria Vilas

; Izar, Maria Cristina de Oliveira

; Costa, Maria Elizabeth Navegantes Caetano

; Castro, Marildes Luiza de

; Lemke, Viviana de Mello Guzzo

; Lucena, Alexandre Jorge Gomes de

; Brandão, Andréa Araujo

; Macedo, Ariane Vieira Scarlatelli

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Nahas, Eliana Petri

; Alexandre, Elizabeth Regina Giunco

; Campana, Erika Maria Gonçalves

; Bragança, Érika Olivier Vilela

; Colombo, Fernanda Marciano Consolim

; Barbosa, Imara Correia de Queiroz

; Rivera, Ivan Romero

; Kulak, Jaime

; Moura, Lidia Ana Zytynski

; Pompei, Luciano de Mello

; Baccaro, Luiz Francisco Cintra

; Barbosa, Marcia Melo

; Rodrigues, Marcio Alexandre Hipólito

; Albernaz, Marco Aurelio

; Decoud, Maria Sotera Paniagua de

; Paiva, Maria Sanali Moura de Oliveira

; Sanchez-Zambrano, Martha Beatriz

; Campos, Milena dos Santos Barros

; Acevedo, Monica

; Ramirez, Monica Susana

; Souza, Olga Ferreira de

; Medeiros, Orlando Otávio de

; Carvalho, Regina Coeli Marques de

; Machado, Rogerio Bonassi

; Silva, Sheyla Cristina Tonheiro Ferro da

; Rodrigues, Thais de Carvalho Vieira

; Avila, Walkiria Samuel

; Costa-Paiva, Lucia Helena Simões da

; Wender, Maria Celeste Osorio

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 Nº 7 elocation e20240478

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20240478

Endophytic bacteria from lettuce seedlings antagonistic to the phytopathogenic fungus Alternaria sp. sp
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Lima, Maria Gabriela Gomes de

; Viana, Milena Campos de Oliveira Alencar

; Moura, Júlia Karoline Ferreira

; Ribeiro, Igor Daniel Alves

; Passaglia, Luciane Maria Pereira

; Barretto, Marcos Cabral de Vasconcellos

; Holanda, Francisco Sandro Rodrigues

; Marino, Regina Helena

Ciência e Agrotecnologia

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2024, Volume 48 elocation e016224

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Microrganismos endofíticos em plantas de alface têm recebido pouca atenção pelo seu potencial controle biológico de fitopatógenos. Este estudo teve como objetivo isolar, identificar e selecionar bactérias endofíticas de plântulas de alface cv. Brava e Creta, antagonistas do fungo fitopatogênico Alternaria sp. (ALT23) em meio de cultura através de interação direta. O delineamento experimental foi inteiramente casualizado em esquema fatorial 11 x 2, com 11 tratamentos [Controle - ALT23 e 10 isolados bacterianos previamente selecionados] e dois períodos de avaliação (5º e 8º dia após a inoculação) com quatro repetições. As sequências do gene 16S rDNA dos isolados revelaram uma alta similaridade com Bacillus tequilensis KCTC 13622, B. subtilis NCIB 3610, B. velezenzis CR-502, B. siamensis KCTC 13613 e Paenibacillus polymyxa ATCC 842. Os isolados bacterianos selecionados reduziram o diâmetro micelial de ALT23 (46,2-65,3%) e a taxa (51,8-91,6%). Concluímos que isolados bacterianos endofíticos com potencial antagônico contra fitopatógenos devem ser selecionados após mais de cinco dias de cultivo em meio de cultura, pois tempos de cultivo mais longos favorecem a atividade inibitória do endófito. isolar cv Creta sp ALT (ALT23 direta 1 2 Controle ALT2 5º º inoculação repetições S 13622 B 3610 CR502, CR502 CR 502, 502 CR-502 1361 842 46,265,3% 462653 46,2 65,3% 46 65 3 (46,2-65,3% 51,891,6%. 518916 51,8 91,6% . 51 8 91 6 (51,8-91,6%) endófito (ALT2 1362 361 CR50 50 CR-50 136 84 265 46,265,3 46265 462 46, 653 65,3 4 (46,2-65,3 891 51,891,6% 51891 518 51, 916 91,6 5 9 (51,8-91,6% (ALT 36 CR5 CR-5 13 26 46,265, 4626 65, (46,2-65, 89 51,891,6 5189 91, (51,8-91,6 CR- 46,265 (46,2-65 51,891, (51,8-91, 46,26 (46,2-6 51,891 (51,8-91 (46,2- 51,89 (51,8-9 (46,2 (51,8- (46, (51,8 (46 (51, (4 (51 ( (5

ABSTRACT Endophytic microorganisms in lettuce plants have received little attention for their potential biological control of phytopathogens. This study aimed to isolate, identify, and select endophytic bacteria from lettuce seedlings cv. Brava and Creta, antagonistic to the phytopathogenic fungus Alternaria sp. (ALT23) in culture media through direct interaction. The experimental design was completely randomized in an 11 x 2 factorial scheme, with 11 treatments [Control - ALT23 and 10 previously selected bacterial isolates] and two evaluation periods (the 5th and 8th day after inoculation) with four replications each. The 16S rDNA gene sequences of the isolates revealed a high similarity with Bacillus tequilensis KCTC 13622, B. subtilis NCIB 3610, B. velezenzis CR-502, B. siamensis KCTC 13613, and Paenibacillus polymyxa ATCC 842. The selected bacterial isolates reduced ALT23 mycelial diameter (46.2-65.3%) and rate (51.8-91.6%). We conclude that endophytic bacterial isolates with antagonistic potential against phytopathogens must be selected after more than five days of cultivation in a culture medium, as longer cultivation times favor endophyte inhibitory activity. isolate identify cv Creta sp ALT (ALT23 interaction 1 scheme Control ALT2 th inoculation each S 13622 B 3610 CR502, CR502 CR 502, 502 CR-502 13613 842 46.265.3% 462653 46.2 65.3% 46 65 3 (46.2-65.3% 51.891.6%. 518916 51.8 91.6% . 51 8 91 6 (51.8-91.6%) medium activity (ALT2 1362 361 CR50 50 CR-50 1361 84 265 46.265.3 46265 462 46. 653 65.3 4 (46.2-65.3 891 51.891.6% 51891 518 51. 916 91.6 5 9 (51.8-91.6% (ALT 136 36 CR5 CR-5 26 46.265. 4626 65. (46.2-65. 89 51.891.6 5189 91. (51.8-91.6 13 CR- 46.265 (46.2-65 51.891. (51.8-91. 46.26 (46.2-6 51.891 (51.8-91 (46.2- 51.89 (51.8-9 (46.2 (51.8- (46. (51.8 (46 (51. (4 (51 ( (5

https://doi.org/10.1590/1413-7054202448016224

Metabolic dysfunction-associated steatotic liver disease prevalence and risk factors in inﬂammatory bowel disease in tertiary center dysfunctionassociated dysfunction associated
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Oliveira, Lívia dos Remédios Pamplona de

; Ribeiro, Tarsila Campanha da Rocha

; Mourao Junior, Carlos Alberto

; Barra, Maria Antônia de Lima

; Silva, Mariana Hippert Gonçalves

; Shafee, Luis Pordeus

; Zacarias, Sarah Mendes

; Campos, Lenilton da Costa

; Valério, Helena Maria Giordano

; Chebli, Júlio Maria Fonseca

Revista da Associação Médica Brasileira

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2024, Volume 70 Nº 6 elocation e20231321

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: The aim of this study was to evaluate the prevalence and risk factors related to metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease patients. METHODS: This is a cross-sectional study conducted on adults with inflammatory bowel disease from 2019 to 2021. Metabolic dysfunction-associated steatotic liver disease encompasses patients with steatosis and at least one cardiometabolic risk factor. Patients with alcohol consumption ≥20 g/day, chronic liver diseases, or methotrexate use were excluded. RESULTS: Almost 140 patients were included: 67.1% were female, with a mean age of 49.7±13.7 years, and 63.6% had Crohn's disease. The mean duration of inflammatory bowel disease was 9.7±7.9 years. Metabolic dysfunction-associated steatotic liver disease was observed in 44.3% and advanced liver fibrosis was excluded in 63.5% by Fibrosis-4. Patients with metabolic dysfunction-associated steatotic liver disease were older (p = 0.003) and had a higher number of metabolic syndrome components (2.9±1.1 versus 1.6±1.0; p<0.001), greater abdominal circumference (p<0.001), and body mass index (p<0.001). The only factor related to inflammatory bowel disease associated with metabolic dysfunction-associated steatotic liver disease was disease duration (11.6±9.5 versus 8.3±6.2; p = 0.017). A higher number of metabolic syndrome components and obesity increase by 2.2 times and an altered waist circumference by 2.6 times the occurrence of metabolic dysfunction-associated steatotic liver disease. CONCLUSION: A high prevalence of metabolic dysfunction-associated steatotic liver disease was observed in patients with inflammatory bowel disease, with the main risk factors being associated with metabolic syndrome predicting it, but not with inflammatory bowel disease features and/or its treatment. OBJECTIVE dysfunctionassociated dysfunction METHODS crosssectional cross sectional 201 2021 20 ≥2 gday g day g/day diseases RESULTS 14 included 671 67 1 67.1 female 497137 49 7 13 49.7±13. years 636 63 6 63.6 Crohns Crohn s 9779 9 9.7±7. 443 44 3 44.3 635 5 63.5 Fibrosis4. Fibrosis4 Fibrosis 4. 4 Fibrosis-4 0.003 0003 0 003 2.9±1.1 2911 2 (2.9±1. 1.6±1.0 1610 p<0.001, p0001 p<0.001 , 001 p<0.001) (p<0.001) p<0.001. . 11.6±9.5 11695 11 (11.6±9. 8.3±6.2 8362 8 0.017. 0017 0.017 017 0.017) 22 2. 26 CONCLUSION it andor treatment 202 ≥ 67. 49713 49.7±13 63. 977 9.7±7 44. Fibrosis- 0.00 000 00 2.9±1. 291 (2.9±1 1.6±1. 161 p000 p<0.00 (p<0.001 11.6±9. 1169 (11.6±9 8.3±6. 836 0.01 01 4971 49.7±1 97 9.7± 0.0 2.9±1 29 (2.9± 1.6±1 16 p00 p<0.0 (p<0.00 11.6±9 116 (11.6± 8.3±6 83 497 49.7± 9.7 0. 2.9± (2.9 1.6± p0 p<0. (p<0.0 11.6± (11.6 8.3± 49.7 9. 2.9 (2. 1.6 p<0 (p<0. 11.6 (11. 8.3 49. (2 1. p< (p<0 11. (11 8. ( (p< (1

https://doi.org/10.1590/1806-9282.20231321

Description of vaccination coverage and hesitancy obtained by epidemiological survey of children born in 2017-2018, in Belo Horizonte and Sete Lagoas, Minas Gerais, Brazil 20172018, 20172018 2017 2018, 2018 2017-2018 Lagoas Gerais 2017201 201 2017-201 201720 20 2017-20 20172 2 2017-2 2017-
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Simões, Taynãna César

; Campos Neto, Orozimbo Henriques

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 Nº spe2 elocation e20231188

Resumo: Pt Es En | Texto: Pt Es En | PDF: Pt | PDF: Es | PDF: En

RESUMO Objetivo Descrever as coberturas e hesitação das vacinas do calendário básico infantil em Belo Horizonte e Sete Lagoas, Minas Gerais. Métodos Inquéritos epidemiológicos de base populacional realizados de 2020 a 2022, para estimar coberturas vacinais por tipo de imunobiológico e esquema completo (doses válidas e aplicadas) segundo estratos socioeconômicos, e os motivos de hesitação vacinal. Resultados A cobertura global com doses válidas e a hesitação vacinal de pelo menos uma vacina foram, respectivamente, de 50,2% (IC95% 44,1;56,2) e 1,6% (IC95% 0,9;2,7), em Belo Horizonte (n = 1.866), e de 64,9% (IC95% 56,9;72,1) e 1,0% (IC95% 0,3;2,8), em Sete Lagoas (n = 451), com diferenças entre os estratos. O receio de reações graves foi o principal motivo de hesitação vacinal. Conclusão Identificou-se coberturas abaixo do preconizado para a maioria das vacinas. A desinformação deve ser combatida, evitando-se a hesitação vacinal. Há necessidade premente de recuperar as coberturas, considerando acesso ao SUS e disparidades socioeconômicas. Gerais 202 2022 aplicadas socioeconômicos foram respectivamente 502 50 2 50,2 IC95% IC95 IC (IC95 44,156,2 441562 44,1 56,2 44 1 56 44,1;56,2 16 6 1,6 0,92,7, 0927 0,9 2,7 , 0 9 7 0,9;2,7) n 1.866, 1866 1.866 866 1.866) 649 64 64,9 56,972,1 569721 56,9 72,1 72 56,9;72,1 10 1,0 0,32,8, 0328 0,3 2,8 3 8 0,3;2,8) 451, 451 451) Identificouse Identificou se combatida evitandose evitando socioeconômicas 20 5 50, IC9 (IC9 156 44,156, 44156 441 44, 562 56, 4 44,1;56, 1, 92 0,92,7 092 09 0, 27 2, 0,9;2,7 186 1.86 86 64, 972 56,972, 56972 569 721 72, 56,9;72, 32 0,32,8 032 03 28 0,3;2,8 45 (IC 15 44,156 4415 44,1;56 0,92, 0,9;2, 18 1.8 97 56,972 5697 56,9;72 0,32, 0,3;2, 44,15 44,1;5 0,92 0,9;2 1. 56,97 56,9;7 0,32 0,3;2 44,1; 0,9; 56,9; 0,3;

resumen está disponible en el texto completo

ABSTRACT Objective To describe vaccination coverage and hesitation for the basic children’s schedule in Belo Horizonte and Sete Lagoas, Minas Gerais state, Brazil. Methods Population-based epidemiological surveys performed from 2020 to 2022, which estimated vaccine coverage by type of immunobiological product and full schedule (valid and ministered doses), according to socioeconomic strata; and reasons for vaccination hesitancy. Results Overall coverage with valid doses and vaccination hesitancy for at least one vaccine were, respectively, 50.2% (95%CI 44.1;56.2) and 1.6% (95%CI 0.9;2.7), in Belo Horizonte (n = 1,866), and 64.9% (95%CI 56.9;72.1) and 1.0% (95%CI 0.3;2.8), in Sete Lagoas (n = 451), with differences between socioeconomic strata. Fear of severe reactions was the main reason for vaccination hesitancy. Conclusion Coverage was identified as being below recommended levels for most vaccines. Disinformation should be combated in order to avoid vaccination hesitancy. There is a pressing need to recover coverages, considering public health service access and socioeconomic disparities. childrens children s state Brazil Populationbased Population based 202 2022 doses, , doses) strata were respectively 502 50 2 50.2 95%CI 95CI CI 95 44.156.2 441562 44.1 56.2 44 1 56 44.1;56.2 16 6 1.6 0.92.7, 0927 0.9 2.7 0 9 7 0.9;2.7) n 1,866, 1866 1,866 866 1,866) 649 64 64.9 56.972.1 569721 56.9 72.1 72 56.9;72.1 10 1.0 0.32.8, 0328 0.3 2.8 3 8 0.3;2.8) 451, 451 451) vaccines coverages disparities 20 5 50. 156 44.156. 44156 441 44. 562 56. 4 44.1;56. 1. 92 0.92.7 092 09 0. 27 2. 0.9;2.7 186 1,86 86 64. 972 56.972. 56972 569 721 72. 56.9;72. 32 0.32.8 032 03 28 0.3;2.8 45 15 44.156 4415 44.1;56 0.92. 0.9;2. 18 1,8 97 56.972 5697 56.9;72 0.32. 0.3;2. 44.15 44.1;5 0.92 0.9;2 1, 56.97 56.9;7 0.32 0.3;2 44.1; 0.9; 56.9; 0.3;

https://doi.org/10.1590/s2237-96222024v33e20231188.especial2.en

10.

Coleoptera of Brazil: what we knew then and what we know now. Insights from the Catálogo Taxonômico da Fauna do Brasil Brazil now
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Caron, Edilson

; Monné, Marcela L.

; Ferreira, Vinicius S.

; Costa, Cleide

; Cupello, Mario

; Aloquio, Sergio

; Linzmeier, Adelita M.

; Vaz-de-Mello, Fernando Z.

; Leivas, Fernando W.T.

; Souza-Gonçalves, Igor

; Mermudes, José R.M.

; Almeida, Lúcia M.

; Moura, Luciano de A.

; Ferreira Júnior, Nelson

; Grossi, Paschoal C.

; Vanin, Sergio A.

; Ślipiński, Adam

; Anichtchenko, Alexander

; Newton, Alfred F.

; Sampaio, Aline

; Carelli, Allan

; Puker, Anderson

; Ferreira, André da S.

; Fernandes, André S.

; Roza, André S.

; Cline, Andrew

; Sampaio, Brunno H.L.

; Clarkson, Bruno

; Castro, Camila F. de

; Bicho, Carla de L.

; Benetti, César J.

; Ribeiro-Costa, Cibele S.

; Lopes-Andrade, Cristiano

; Manfio, Daiara

; Colpani, Daniara

; Basílio, Daniel S.

; Bená, Daniela de C.

; Pollock, Darren A.

; Souza, Diego de S.

; Rodrigues, Diego F.

; Chandler, Donald S.

; Nascimento, Elynton A. do

; Spiessberger, Erich L.

; Agrain, Federico A.

; Barbosa, Felipe F.

; Shockley, Floyd

; Nascimento, Francisco E. de L.

; Biffi, Gabriel

; Powell, Gareth S.

; Morse, Geoffrey E.

; Flores, Gustavo E.

; Escalona, Hermes

; Quintino, Hingrid Y.S.

; Rainho, Hugo L.

; Maddalena, Italo S.C.P.

; Hájek, Jiří

; McHugh, Joseph V.

; Botero, Juan P.

; Fuhrmann, Juares

; Churata-Salcedo, Julissa M.

; Vieira, Letícia M.

; Silveira, Luiz F.L. da

; Cruz, Luiza S. da

; Sekerka, Lukás

; Bologna, Marco A.

; Bevilaqua, Marcus V.O.

; Passos, Maria I.

; Chamorro, Maria L.

; Cherman, Mariana A.

; Bento, Matheus

; Gimmel, Matthew

; Segura, Melissa O.

; Ivie, Michael A.

; Thomas, Michael C.

; Monné, Miguel A.

; Lord, Nathan

; Hamada, Neusa

; Degallier, Nicolas

; Santos, Paula B. dos

; Duarte, Paulo R.M.

; Gnaspini, Pedro

; Bulirsch, Petr

; Regalin, Renato

; Leschen, Richard A.B.

; Constantin, Robert

; Corrêa, Rodrigo C.

; Gerstmeier, Roland

; Rosa, Simone P.

; Campos, Stéphanie V.N.

; Peck, Stewart B.

; Pacheco, Thaynara L.

; Polizei, Thiago T.S.

; McElrath, Thomas C.

; Grzymala, Traci L.

; Smith, Trevor R.

; Costa-Silva, Vinicius da Sandoval-Gómez, Vivian E. Sousa, Wesley O. de Tomaszewska, Wioletta

Zoologia (Curitiba)

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2024, Volume 41 elocation e23072

Resumo: En | Texto: En | PDF: En

ABSTRACT In 2000, Cleide Costa published a paper presenting the state of knowledge of the Neotropical Coleopte ra, with a focus on the Brazilian fauna. Twenty-four years later, thanks to the development of the Coleoptera section of the Taxonomic Catalog of the Brazilian Fauna (CTFB - Catálogo Taxonômico da Fauna do Brasil) through the collaboration of 100 coleopterists from all over the globe, we can build on Costa’s work and present an updated overview of the state of knowledge of the beetles from Brazil. There are currently 35,699 species in 4,958 genera and 116 families known to occur in the country, including representatives of all extant suborders and superfamilies. Our data show that the Brazilian beetle fauna is the richest on the planet, concentrating 9% of the world species diversity, with some estimates accounting to up to 15% of the global total. The most diverse family in numbers of genera is Cerambycidae (1,056 genera), while in number of species it is Chrysomelidae (6,079 species). Conotrachelus Dejean, 1835 (Curculionidae) is the most species-rich genus, with 570 species. The French entomologist Maurice Pic is the author who has contributed the most to the naming of species recorded from Brazil, with 1,794 valid names in 36 families, whereas the Brazilians Ubirajara R. Martins and Maria Helena M. Galileo are the only ones among the top-ten authors to have named species in the 21st century. Currently, approximately 144 new species of Brazilian beetles are described each year, and this average is projected to increase in the next decade to 180 species per year, or about one new Brazilian beetle every two days. 2000 ra Twentyfour Twenty four later CTFB Brasil 10 globe Costas s Brazil 35699 35 699 35,69 4958 4 958 4,95 11 country superfamilies planet 9 diversity 15 total 1,056 1056 1 056 (1,05 genera, , genera) 6,079 6079 6 079 (6,07 . species) Dejean 183 Curculionidae (Curculionidae speciesrich rich genus 57 1794 794 1,79 3 R M topten top ten st century Currently 14 year 18 days 200 3569 69 35,6 495 95 4,9 1,05 105 05 (1,0 6,07 607 07 (6,0 5 179 79 1,7 20 356 35, 49 4, 1,0 0 (1, 6,0 60 (6, 17 7 1, 2 (1 6, (6 (

https://doi.org/10.1590/s1984-4689.v41.e23072

11.

Hepatitis A vaccination coverage survey in 24-month-old children living in Brazilian capitals, 2020
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Moura, Winny Éveny Alves

; Caetano, Karlla Antonieta Amorim

; Lima, Juliana de Oliveira Roque e

; Campos, Lays Rosa

; Silva, Grazielle Rosa da Costa e

; Moraes, José Cássio de

; França, Ana Paula

; Domingues, Carla Magda Allan Santos

; Teixeira, Maria da Gloria Lima Cruz

; Teles, Sheila Araújo

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 Nº spe2 elocation e20231162

Resumo: Pt Es En | Texto: Pt Es En | PDF: Pt | PDF: Es | PDF: En

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231162.en

12.

Description of vaccination coverage and hesitancy obtained by epidemiological survey of children born in 2017-2018, in Belo Horizonte and Sete Lagoas, Minas Gerais, Brazil
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Simões, Taynãna César

; Campos Neto, Orozimbo Henriques

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 Nº spe2 elocation e20231188

Resumo: Pt Es En | Texto: Pt Es En | PDF: Pt | PDF: Es | PDF: En

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231188.especial2.en

13.

Brazilian Guideline on Menopausal Cardiovascular Health – 2024 202 20 2
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Oliveira, Gláucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Arcelus, Carolina María Artucio

; Espíndola Neto, Larissa

; Rivera, Maria Alayde Mendonça

; Silva-Filho, Agnaldo Lopes da

; Marques-Santos, Celi

; Fernandes, César Eduardo

; Albuquerque, Carlos Japhet da Matta

; Freire, Claudia Maria Vilas

; Izar, Maria Cristina de Oliveira

; Costa, Maria Elizabeth Navegantes Caetano

; Castro, Marildes Luiza de

; Lemke, Viviana de Mello Guzzo

; Lucena, Alexandre Jorge Gomes de

; Brandão, Andréa Araujo

; Macedo, Ariane Vieira Scarlatelli

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Nahas, Eliana Petri

; Alexandre, Elizabeth Regina Giunco

; Campana, Erika Maria Gonçalves

; Bragança, Érika Olivier Vilela

; Colombo, Fernanda Marciano Consolim

; Barbosa, Imara Correia de Queiroz

; Rivera, Ivan Romero

; Kulak, Jaime

; Moura, Lidia Ana Zytynski

; Pompei, Luciano de Mello

; Baccaro, Luiz Francisco Cintra

; Barbosa, Marcia Melo

; Rodrigues, Marcio Alexandre Hipólito

; Albernaz, Marco Aurelio

; Decoud, Maria Sotera Paniagua de

; Paiva, Maria Sanali Moura de Oliveira

; Sanchez-Zambrano, Martha Beatriz

; Campos, Milena dos Santos Barros

; Acevedo, Monica

; Ramirez, Monica Susana

; Souza, Olga Ferreira de

; Medeiros, Orlando Otávio de

; Carvalho, Regina Coeli Marques de

; Machado, Rogerio Bonassi

; Silva, Sheyla Cristina Tonheiro Ferro da

; Rodrigues, Thais de Carvalho Vieira

; Avila, Walkiria Samuel

; Costa-Paiva, Lucia Helena Simões da

; Wender, Maria Celeste Osorio

Revista Brasileira de Ginecologia e Obstetrícia

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2024, Volume 46 elocation e-rbgo100

Resumo: En | Texto: En | PDF: En

https://doi.org/10.61622/rbgo/2024rbgo100

14.

Follicular cell-derived thyroid carcinomas harboring novel genetic BRAFNON-V600E mutations: real-world data obtained using a multigene panel cellderived cell derived BRAFNONV600E BRAFNONVE BRAFNON V600E V E mutations realworld real world BRAFNONV VE
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Ammon, Juliana Lima von

; Machado, Gabriel Jeferson Rodríguez

; da Matta, Rafael Reis Campos

; Telles, Ana Clara

; Carrijo, Fabiane

; dos Santos, Bruno Alexsander França

; Brandão, Juliana Cabral Duarte

; da Silva, Thiago Magalhães

; Hecht, Fabio

; Colozza-Gama, Gabriel Avela

; Tezzei, Julia Helena

; Cerutti, Janete Maria

; Ramos, Helton Estrela

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e240067

Resumo: En | Texto: En | PDF: En

ABSTRACT Objectives: To assess the molecular profile of follicular cell-derived thyroid carcinomas (FCDTCs) and correlate the identified mutations with the clinical and pathological features of the affected patients. Materials and methods: Cross-sectional study of tumor samples from 100 adult patients diagnosed with FCDTC between 2010 and 2019. The patients’ clinical and pathological data were collected. Genomic DNA was extracted from formalin-fixed, paraffin-embedded (FFPE) tumors using the ReliaPrep FFPE gDNA Miniprep System. Genotyping of target genomic regions (KRAS, NRAS, BRAF, EGFR, and PIK3CA) was performed using the AmpliSeq panel, while sequencing was performed on the iSeq 100 platform. Results: The patients’ mean age was 39 years. In all, 82% of the tumors were classic papillary thyroid carcinomas. Overall, 54 (54%) tumor samples yielded satisfactory results on next-generation sequencing (NGS), of which 31 harbored mutations. BRAF gene mutations were the most frequent, with the BRAFV600E mutation present in 10 tumors. Seven tumors had BRAFNON-V600E mutations not previously described in FCDTCs (G464E, G464R, G466E, S467L, G469E, G596D, and the T599Ifs*10 deletion) but described in other types of cancer (i.e., skin/melanoma, lung, colorectal, and others). One tumor had a previously reported BRAFA598V mutation. EGFR gene mutations were found in 16 (29%) and KRAS or NRAS alterations in 8 (14%) of the 54 tumors analyzed. Conclusion: We described herein seven non-hotspot/novel variants in the BRAF gene, highlighting their potential role in expanding our understanding of FCDTC genetics. Objectives cellderived cell derived (FCDTCs methods Crosssectional Cross sectional 201 2019 collected formalinfixed, formalinfixed formalin fixed, fixed formalin-fixed paraffinembedded paraffin embedded (FFPE System KRAS, (KRAS PIK3CA PIKCA PIK CA panel platform Results 3 years all 82 Overall 5 54% (54% nextgeneration next generation NGS, NGS , (NGS) frequent BRAFVE BRAFV E 1 BRAFNONV600E BRAFNONVE BRAFNON V600E V G464E, G464E GE G (G464E G464R GR R G466E S467L SL S L G469E G596D GD D T599Ifs10 TIfs T599Ifs T Ifs T599Ifs*1 deletion i.e., ie i e (i.e. skinmelanoma skin melanoma skin/melanoma lung colorectal others. others . others) BRAFAV BRAFA 29% 29 (29% 14% 14 (14% analyzed Conclusion nonhotspot/novel nonhotspotnovel non hotspot/novel hotspot novel genetics 20 (54 (NGS BRAFNONV VE T599Ifs1 T599Ifs* i.e. (i.e 2 (29 (14 nonhotspot hotspotnovel (5 i.e (2 (1 (

https://doi.org/10.20945/2359-4292-2024-0067

15.

Hepatitis A vaccination coverage survey in 24-month-old children living in Brazilian capitals, 2020 24monthold monthold 24 month old capitals 202 2 20
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Moura, Winny Éveny Alves

; Caetano, Karlla Antonieta Amorim

; Lima, Juliana de Oliveira Roque e

; Campos, Lays Rosa

; Silva, Grazielle Rosa da Costa e

; Moraes, José Cássio de

; França, Ana Paula

; Domingues, Carla Magda Allan Santos

; Teixeira, Maria da Gloria Lima Cruz

; Teles, Sheila Araújo

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 Nº spe2 elocation e20231162

Resumo: Pt Es En | Texto: Pt Es En | PDF: Pt | PDF: Es | PDF: En

RESUMO Objetivo Estimar a cobertura vacinal da hepatite A em crianças de 24 meses e identificar fatores associados à ausência de vacinação. Métodos Inquérito em amostra estratificada por estratos socioeconômicos em capitais (2020-2022), com estimativa de cobertura e intervalos de confiança de 95% (IC95%) e análise de fatores pela razão de prevalência (RP) via regressão de Poisson. Resultados Nas 31.001 crianças, a cobertura da hepatite A foi de 88,1% (IC95% 86,8;89,2). Nos estratos socioeconômicos (A/B), a variável pais/responsáveis imigrantes foi associada à ausência de vacinação (RP = 1,91; IC95% 1,09;3,37); nos estratos C/D, crianças de cor amarela (RP = 4,69; IC95% 2,30;9,57), 4ª ordem de nascimento ou mais (RP = 1,68; IC95% 1,06;2,66), não frequentar creche/berçário (RP = 1,67; IC95% 1,24;2,24) e mãe com trabalho remunerado (RP = 1,42; IC95% 1,16;1,74) foram associadas à ausência de vacinação. Conclusão Cobertura da hepatite A abaixo da meta (95%), sugerindo-se considerar especificidades dos estratos sociais. 2 20202022, 20202022 2020 2022 , (2020-2022) 95 IC95 IC RP Poisson 31001 31 001 31.00 881 88 1 88,1 (IC95 86,889,2. 868892 86,8 89,2 . 86 8 89 86,8;89,2) A/B, AB A/B B (A/B) paisresponsáveis pais responsáveis 1,91 191 91 1,093,37 109337 1,09 3,37 09 3 37 1,09;3,37) CD C D C/D 4,69 469 4 69 2,309,57, 230957 2,30 9,57 30 9 57 2,30;9,57) ª 1,68 168 68 1,062,66, 106266 1,06 2,66 06 66 1,06;2,66) crecheberçário creche berçário 1,67 167 67 1,242,24 124224 1,24 2,24 1,24;2,24 1,42 142 42 1,161,74 116174 1,16 1,74 16 74 1,16;1,74 95%, (95%) sugerindose sugerindo se sociais 2020202 202 (2020-2022 IC9 3100 00 31.0 88, (IC9 889 86,889,2 86889 868 86, 892 89, 86,8;89,2 (A/B 1,9 19 093 1,093,3 10933 109 1,0 337 3,3 0 1,09;3,37 4,6 46 6 309 2,309,57 23095 230 2,3 957 9,5 5 2,30;9,57 1,6 062 1,062,66 10626 106 266 2,6 1,06;2,66 242 1,242,2 12422 124 1,2 224 2,2 1,24;2,2 1,4 14 161 1,161,7 11617 116 1,1 174 1,7 7 1,16;1,7 (95% 202020 20 (2020-202 310 31. (IC 86,889, 8688 86,8;89, 1, 1,093, 1093 10 33 3, 1,09;3,3 4, 2,309,5 2309 23 2, 9, 2,30;9,5 1,062,6 1062 26 1,06;2,6 1,242, 1242 12 22 1,24;2, 1,161, 1161 11 17 1,16;1, (95 20202 (2020-20 86,889 86,8;89 1,093 1,09;3, 2,309, 2,30;9, 1,062, 1,06;2, 1,242 1,24;2 1,161 1,16;1 (9 (2020-2 86,88 86,8;8 1,09;3 2,309 2,30;9 1,062 1,06;2 1,24; 1,16; ( (2020- 86,8; 1,09; 2,30; 1,06; (2020 (202 (20 (2

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ABSTRACT Objective To estimate hepatitis A vaccination coverage in 24-month-old children and identify factors associated with non-vaccination. Methods This was a survey involving a sample stratified by socioeconomic strata in capital cities (2020-2022), with coverage estimates and 95% confidence intervals (95%CI), the factor analysis was performed using the prevalence ratio (PR) by means of Poisson regression. Results Among 31,001 children, hepatitis A coverage was 88.1% (95%CI 86.8;89.2). Regarding socioeconomic strata (A/B), the variable immigrant parents/guardians was associated with non-vaccination (PR = 1.91; 95%CI 1.09;3.37); in strata C/D, children of Asian race/skin color (PR = 4.69; 95%CI 2.30;9.57), fourth-born child or later (PR = 1.68; 95%CI 1.06;2 .66), not attending daycare/nursery (PR = 1.67; 95%CI 1.24;2.24) and mother with paid work (PR = 1.42; 95%CI 1.16;1.74) were associated with non-vaccination. Conclusion Hepatitis A coverage was below the target (95%), suggesting that specificities of social strata should be taken into consideration. 24monthold monthold 24 month old nonvaccination. nonvaccination non vaccination. 20202022, 20202022 2020 2022 , (2020-2022) 95 95%CI, 95CI CI (95%CI) PR regression 31001 31 001 31,00 881 88 1 88.1 86.889.2. 868892 86.8 89.2 . 86 8 89 2 86.8;89.2) A/B, AB A/B B (A/B) parentsguardians parents guardians 1.91 191 91 1.093.37 109337 1.09 3.37 09 3 37 1.09;3.37) CD C D C/D raceskin race skin 4.69 469 4 69 2.309.57, 230957 2.30 9.57 30 9 57 2.30;9.57) fourthborn fourth born 1.68 168 68 1.062 1062 1.06 06 1.06; .66, 66 .66 .66) daycarenursery daycare nursery 1.67 167 67 1.242.24 124224 1.24 2.24 1.24;2.24 1.42 142 42 1.161.74 116174 1.16 1.74 16 74 1.16;1.74 95%, (95%) consideration 2020202 202 (2020-2022 3100 00 31,0 88. 889 86.889.2 86889 868 86. 892 89. 86.8;89.2 (A/B 1.9 19 093 1.093.3 10933 109 1.0 337 3.3 0 1.09;3.37 4.6 46 6 309 2.309.57 23095 230 2.3 957 9.5 5 2.30;9.57 1.6 062 106 .6 242 1.242.2 12422 124 1.2 224 2.2 1.24;2.2 1.4 14 161 1.161.7 11617 116 1.1 174 1.7 7 1.16;1.7 (95% 202020 20 (2020-202 310 31, 86.889. 8688 86.8;89. 1. 1.093. 1093 10 33 3. 1.09;3.3 4. 2.309.5 2309 23 2. 9. 2.30;9.5 1.242. 1242 12 22 1.24;2. 1.161. 1161 11 17 1.16;1. (95 20202 (2020-20 86.889 86.8;89 1.093 1.09;3. 2.309. 2.30;9. 1.242 1.24;2 1.161 1.16;1 (9 (2020-2 86.88 86.8;8 1.09;3 2.309 2.30;9 1.24; 1.16; ( (2020- 86.8; 1.09; 2.30; (2020 (202 (20 (2

https://doi.org/10.1590/s2237-96222024v33e20231162.en

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