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RESUMO Introdução: Doenças pulmonares são comuns em pacientes com doença renal em estágio terminal (DRET), dificultando o diagnóstico diferencial com COVID-19. Este estudo descreve achados de tomografia computadorizada de tórax (TC) em pacientes com DRET em terapia renal substitutiva (TRS) hospitalizados com suspeita de COVID-19. Métodos: Indivíduos maiores de 18 anos com DRET, encaminhados ao pronto-socorro com suspeita de COVID-19 foram incluídos. Dados clínicos e epidemiológicos foram extraídos de registros eletrônicos de saúde. A TC foi classificada como típica, indeterminada, atípica, negativa. Comparamos achados tomográficos de pacientes com COVID-19 positivos e negativos. Resultados: Recrutamos 109 pacientes (62,3% COVID-19-positivos) entre março e dezembro de 2020, idade média de 60 ± 12,5 anos, 43% mulheres. A etiologia mais comum da DRET foi diabetes. Tempo médio em diálise foi 36 meses, intervalo interquartil = 12–84. A lesão pulmonar mais comum foi opacidades em vidro fosco. O padrão típico de TC foi mais comum em pacientes com COVID-19 (40 (61%) vs. 0 (0%) em pacientes sem COVID-19, p < 0,001). Sensibilidade 60,61% (40/66), especificidade 100% (40/40). Valores preditivos positivos e negativos foram 100% e 62,3%, respectivamente. Padrão atípico de TC foi mais frequente em pacientes COVID-19-negativos (9 (14%) vs. 24 (56%) em COVID-19-positivos, p < 0,001), enquanto padrão indeterminado foi semelhante em ambos os grupos (13 (20%) vs. 6 (14%), p = 0,606), e padrão negativo foi mais comum em pacientes COVID-19-negativos (4 (6%) vs. 12 (28%), p = 0,002). Conclusões: Em pacientes com DRET em TRS hospitalizados, um padrão atípico de TC de tórax não pode excluir adequadamente o diagnóstico de COVID-19. Introdução , (DRET) COVID19. COVID19 COVID 19. 19 (TC (TRS Métodos 1 prontosocorro pronto socorro COVID-1 incluídos saúde típica indeterminada atípica negativa Resultados 10 62,3% 623 62 3 (62,3 COVID19positivos COVIDpositivos COVID-19-positivos 2020 125 5 12, 43 mulheres diabetes meses 1284 84 12–84 fosco 40 61% 61 (61% vs 0% (0% COVID19, 19, 0,001. 0001 0,001 . 001 0,001) 6061 60,61 40/66, 4066 40/66 66 (40/66) 100 40/40. 4040 40/40 (40/40) respectivamente COVID19negativos COVIDnegativos 9 ( 14% 14 (14% 2 56% 56 (56% COVID19positivos, positivos, 0,001, 13 (1 20% 20 (20% 14%, 0,606, 0606 0,606 606 0,606) 4 6% (6% 28%, 28 28% (28%) 0,002. 0002 0,002 002 0,002) Conclusões (DRET COVID1 COVID- 62,3 (62, 202 128 8 12–8 (61 (0 000 0,00 00 60,6 406 40/6 (40/66 404 40/4 (40/40 (14 (56 (20 060 0,60 (6 (28% 62, (62 12– 0,0 60, 40/ (40/6 (40/4 (5 (2 06 0,6 (28 0, (40/

ABSTRACT Introduction: Lung diseases are common in patients with end stage kidney disease (ESKD), making differential diagnosis with COVID-19 a challenge. This study describes pulmonary chest tomography (CT) findings in hospitalized ESKD patients on renal replacement therapy (RRT) with clinical suspicion of COVID-19. Methods: ESKD individuals referred to emergency department older than 18 years with clinical suspicion of COVID-19 were recruited. Epidemiological baseline clinical information was extracted from electronic health records. Pulmonary CT was classified as typical, indeterminate, atypical or negative. We then compared the CT findings of positive and negative COVID-19 patients. Results: We recruited 109 patients (62.3% COVID-19-positive) between March and December 2020, mean age 60 ± 12.5 years, 43% female. The most common etiology of ESKD was diabetes. Median time on dialysis was 36 months, interquartile range = 12–84. The most common pulmonary lesion on CT was ground glass opacities. Typical CT pattern was more common in COVID-19 patients (40 (61%) vs 0 (0%) in non-COVID-19 patients, p < 0.001). Sensitivity was 60.61% (40/66) and specificity was 100% (40/40). Positive predictive value and negative predictive value were 100% and 62.3%, respectively. Atypical CT pattern was more frequent in COVID-19-negative patients (9 (14%) vs 24 (56%) in COVID-19-positive, p < 0.001), while the indeterminate pattern was similar in both groups (13 (20%) vs 6 (14%), p = 0.606), and negative pattern was more common in COVID-19-negative patients (4 (6%) vs 12 (28%), p = 0.002). Conclusions: In hospitalized ESKD patients on RRT, atypical chest CT pattern cannot adequately rule out the diagnosis of COVID-19. Introduction ESKD, , (ESKD) COVID19 COVID 19 COVID-1 challenge (CT RRT (RRT COVID19. 19. Methods 1 records typical Results 10 62.3% 623 62 3 (62.3 COVID19positive COVIDpositive COVID-19-positive 2020 125 5 12. 43 female diabetes months 1284 84 12–84 opacities 40 61% 61 (61% 0% (0% nonCOVID19 nonCOVID non non-COVID-1 0.001. 0001 0.001 . 001 0.001) 6061 60.61 40/66 4066 66 (40/66 100 40/40. 4040 40/40 (40/40) respectively COVID19negative COVIDnegative 9 ( 14% 14 (14% 2 56% 56 (56% COVID19positive, positive, 0.001, 13 (1 20% 20 (20% 14%, 0.606, 0606 0.606 606 0.606) 4 6% (6% 28%, 28 28% (28%) 0.002. 0002 0.002 002 0.002) Conclusions (ESKD COVID1 COVID- 62.3 (62. 202 128 8 12–8 (61 (0 nonCOVID1 non-COVID- 000 0.00 00 60.6 40/6 406 (40/6 404 40/4 (40/40 (14 (56 (20 060 0.60 (6 (28% 62. (62 12– non-COVID 0.0 60. 40/ (40/ (40/4 (5 (2 06 0.6 (28 0.

https://doi.org/10.1590/2175-8239-jbn-2023-0029en

Para una genealogía de la biopolítica italiana: Roberto Esposito y la recepción temprana de los cursos de Michel Foucault
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Castro, Edgardo

Tópicos (México)

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Ago 2024, Nº 69 Páginas 257 - 283

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract. This paper deals with the reception of the Foucauldian notion of governmentality in Roberto Esposito’s thought by taking into account the Italian translation of Foucault’s lectures of 1977 and 1978 at the Collège de France. First, the different contexts of reception of these lectures are presented, in particular the Anglo-Saxon studies of governmentality and the crisis of Italian Marxism in the late 1970s. Secondly, Foucault’s position in his courses of these years is analyzed from the perspective of the opposition between Machiavellianism and anti-Machiavellianism, precisely in view of the Italian reception. Finally, this paper analyses the reception of the notion of governmentality by Roberto Esposito in his 1980 work La politica e la storia. The paper shows the importance of this early reception of Foucault’s lessons regarding the formation of the Italian biopolitical current and its specificities.

Resumen. Este artículo se ocupa de la recepción de la noción foucaultiana de “gubernamentalidad” en el pensamiento de Roberto Esposito a partir de la traducción al italiano de las lecciones de Foucault de los años 1977 y 1978 en el Collège de France. En primer lugar, se exponen los diferentes contextos de recepción de estas lecciones, en particular en el ámbito anglosajón de los estudios sobre la gubernamentalidad y en el de la crisis del marxismo italiano de finales de los setenta. En segundo lugar, se analiza la posición de Foucault en sus cursos de estos años desde la perspectiva de la oposición entre maquiavelismo y antimaquiavelismo en vista, precisamente, de la recepción italiana. Por último, se aborda la recepción de la noción de “gubernamentalidad” por parte de Roberto Esposito en su obra de 1980, La politica e la storia. El artículo muestra la importancia de esta recepción temprana de las lecciones de Foucault respecto de la formación de la corriente biopolítica italiana y, sobre todo, sus especificidades.

https://doi.org/10.21555/top.v690.2606

Clinical Characteristics of Genuine Acute Autoimmune Hepatitis
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Oliveira, Elze Maria Gomes

; Amaral, Ana Cristina de Castro

; Oliveira, Patricia Marinho Costa

; Lanzoni, Valéria Pereira

; Perez, Renata Mello

; Narciso-Schiavon, Janaína Luz

; Whale, Raul Carlos

; Carvalho-Filho, Roberto José

; Silva, Antonio Eduardo Benedito

; Ferraz, Maria Lucia Cardoso Gomes

GE-Portuguese Journal of Gastroenterology

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Jun 2024, Volume 31 Nº 3 Páginas 21 - 29

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Introduction: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis, chronic hepatitis, and decompensated cirrhosis. The acute presentation is not rare and could represent genuine acute AIH (GAAIH) or acute exacerbation of chronic autoimmune hepatitis. We aimed to identify the prevalence, clinical features, and prognostic factors associated with GAAIH and compare these cases with acute exacerbation of chronic AIH. Methods: This cross-sectional observational study evaluated patients with acute AIH presentation, deﬁned as total bilirubin >5 times the upper limit of normality (xULN) and/or alanine aminotransferase >10 xULN, and no prior history of liver disease. Histology ﬁndings of acute disease deﬁned GAAIH. Bivariate analyses were performed to identify factors associated with the GAAIH, when compared with acute exacerbation of chronic AIH. Results: Seventy-two patients with acute presentation of AIH were included and six (8.3%) of them presented GAAIH. Comparative analysis between patients with GAAIH and patients with acute exacerbation of chronic AIH revealed that prothrombin activity (96% [74-100] vs. 61% [10-100]; p = 0.003) and albumin levels (3.9 ± 0.2 g/dL vs. 3.4 ± 0.5 g/dL; p < 0.001) were higher in patients with GAAIH. The International Autoimmune Hepatitis Group score was higher in patients with acute exacerbation of chronic AIH (18.5 [8-23] vs. 16.5 [15-17]; p = 0.010). Compared to 15.2% of acute exacerbation of chronic AIH, complete therapeutic response to treatment was achieved in 67.7% of cases with GAAIH (p = 0.018). Conclusions: GAAIH was rare (8.3%), and patients with this presentation exhibited more preserved liver function tests, suggesting that most cases presenting with loss of function are acute exacerbation of chronic AIH. Additionally, patients with GAAIH had a better complete therapeutic response, suggesting a more preserved liver function at presentation, and early diagnosis has a positive therapeutic implication.

Resumo Introdução: A hepatite autoimune (HAI) apresenta um espectro de sintomas que varia de doença assintomática a hepatite aguda grave, hepatite crónica e cirrose descompensada. A apresentação aguda não é rara e pode representar hepatite autoimune aguda genuína (HAIAG) ou exacerbação aguda de hepatite autoimune crónica (EAHAIC). O nosso objetivo foi identiﬁcar a prevalência, caraterísticas clínicas e fatores prognósticos associados à HAIAG, e comparar esses casos com EAHAIC. Métodos: Estudo observacional, transversal, incluindo doentes com apresentação aguda de HAI, deﬁnida como bilirrubina total > 5 vezes o limite superior da normalidade (xLSN) e/ou ALT > 10 xLSN, e sem história prévia de doença hepática. HAIAG foi deﬁnida pela presença de achados histológicos de doença aguda. Análises bivariadas foram realizadas para identiﬁcar fatores associados à HAIAG, quando comparado com o EAHAIC. Resultados: Foram incluídos setenta e dois doentes com apresentação agu-da de HAI, dos quais seis (8.3%) com HAIAG. A análise comparativa entre doentes com HAIAG e doentes com EAHAIC mostrou que a atividade de protrombina (96%(74-100) versus 61% (10-100; p=0.003) e os níveis de albumina (3,9 ± 0,2 g/dL vs. 3,4 ± 0,5 g/dL; p < 0,001) foram signiﬁcativamente mais elevados em pacientes com HAIAG. O score do Grupo Internacional de Hepatite Autoimune foi mais elevado em doentes com EAHAIC (18.5 (8-23) versus 16.5 (15-17); p=0.010). A resposta terapêutica completa ao tratamento foi alcançada em 66.7% dos casos de HAIAG (vs. 15,2% na EAHAIC, p=0,018). Conclusões: A HAIAG é rara (8.3%), e os doentes com esta apresentação mostraram testes de função hepática mais preservados, sugerindo que a maioria dos casos com perda de função são EAHAIC. Além disso, os doentes com HAIAG tiveram maior taxa de resposta terapêutica completa, sugerindo que uma função hepática mais preservada na apresentação e o diagnóstico precoce tem uma implicação terapêutica positiva.

https://doi.org/10.1159/000531018

Botana de maíz y residuos de cáliz de Jamaica: optimización de proceso
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Rivera-Castro, Víctor Manuel

; Gutiérrez-Dorado, Roberto

; Gutiérrez-Grijalva, Erick Paul

; Basilio Heredia, José

; Muy-Rangel, María Dolores

Revista mexicana de ciencias agrícolas

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Mai 2024, Volume 15 Nº 3 elocation e3666

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Rich in fiber and bioactive compounds, roselle calyx decoction residues offer opportunities in food processing. This study sought to develop a directly expanded snack with a mixture of corn and roselle calyx decoction residues, optimizing its physical qualities. It was conducted in 2023, using the response surface methodology with three factors and three responses. The directly expanded snack showed expansion index values between 1.75 to 2.64, bulk density of 0.15 to 0.38 g cm-3 and firmness of 6.8 to 19.6 N, with attractive purple-lilac shades. The regression models were adequate and using the desirability method, optimal conditions (OT= 132.3 °C, SS= 240 rpm) and roselle inclusion level (J= 12.4%) were determined for an optimized directly expanded snack. It was concluded that the inclusion of up to 12.4% of roselle calyx allowed obtaining snacks with excellent physical characteristics.

Resumen Los residuos de decocción cáliz de jamaica, ricos en fibra y compuestos bioactivos, ofrecen oportunidades en la elaboración de alimentos. Este estudio buscó desarrollar una botana directamente expandida con mezcla de maíz y residuos de decocción cáliz de jamaica, optimizando sus cualidades físicas. Se realizó en el año 2023, empleando la metodología de superficie de respuesta con tres factores y tres respuestas. La botana directamente expandida, mostraron valores de índice de expansión entre 1.75 a 2.64, densidad aparente de 0.15 a 0.38 g cm-3 y firmeza de 6.8 a 19.6 N, con tonalidades morado-lila atractivas. Los modelos de regresión fueron adecuados y mediante el método de deseabilidad, se determinaron condiciones óptimas (TS= 132.3 °C, VT= 240 rpm) y nivel de inclusión de jamaica (J= 12.4%) para una botana directamente expandida optimizada. Se concluyó que la inclusión de hasta un 12.4% de cáliz de jamaica permitió obtener botanas con excelentes características físicas.

https://doi.org/10.29312/remexca.v15i3.3666

Efecto de biofertilizantes en el recuento de rizobios e indicadores morfológicos del frijol ejotero (Phaseolus vulgaris L.), en Ecuador
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Cáceres-Acosta, Edwin Alfredo

; Aguirre-Flores, Alejandro Alfredo

; Castro-Brindis, Rogelio

; Almaraz-Suárez, Juan José

; Colinas-León, María Teresa

; Juárez-Hernández, Ma. de Jesús

; Montes-Colmenares, Roberto Odón

Chilean journal of agricultural & animal sciences

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Abr 2024, Volume 40 Nº 1 Páginas 66 - 80

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen: El nitrógeno en el suelo es crucial para la agricultura, pero a menudo es limitante, afectando el rendimiento de los cultivos. La deficiencia requiere fertilizantes sintéticos, pero su uso inadecuado causa daños ambientales y costos elevados. Las bacterias del género Rhizobium, simbiontes de leguminosas, ofrecen una solución al fijar nitrógeno de manera sostenible, reduciendo la dependencia de fertilizantes. Esta investigación determinó el número más probable (NMP) de células de Rhizobium spp. procedente de dos biofertilizantes comerciales de origen ecuatoriano y mexicano en condiciones de invernadero. Para esto, se realizó la inoculación directa con disoluciones seriadas (10-1 a 10-10) en macetas con pomina esterilizada al vapor, donde se germinaron plantas de frijol ejotero (Phaseolus vulgaris L.) de la variedad Blue Lake. A los 45 días después de siembra (DDS) se evaluaron los siguientes indicadores morfológicos: área foliar, peso de la planta en húmedo, altura de planta y número de flores, determinándose diferencias estadísticas entre el tipo de biofertilizante y la concentración de cada dilución. El experimento se adecuó a un diseño de bloques completos al azar con arreglo de parcela dividida con tres repeticiones por dilución, en consideración de las fluctuaciones de temperatura presentes en la zona de estudio. El NMP, al 95% de confianza, fue de 4,45x107 rizobios g-1 de pomina en una dilución 10-5 para el biofertilizante mexicano, y 1,48x105 rizobios g-1 de pomina en una dilución 10-4 para el biofertilizante ecuatoriano. La dilución óptima estimada para ambos productos fue de 10-8.

Abstract: Soil nitrogen is crucial for agriculture, but it is often limited, affecting crop yields. Deficiency requires synthetic fertilizers, but their improper use results in environmental damage and high costs. Bacteria of the genus Rhizobium, symbionts of legumes, offer a sustainable solution by fixing nitrogen, thus reducing dependence on fertilizers. This research determined the most probable number (MPN) of cells of Rhizobium spp. from two commercial biofertilizers of Ecuadorian and Mexican origin under greenhouse conditions. For this, direct inoculation with serial dilutions (10-1 to 10-10) was performed in pots with steam-sterilized pumice where Blue Lake variety snap bean (Phaseolus vulgaris L.) plants were germinated. The following morphological indicators were evaluated at 45 days after sowing (DAS): leaf area, plant wet weight, plant height, and number of flowers, determining statistical differences between the type of biofertilizer and the concentration of each dilution. The experiment followed a randomized complete block design with a split-plot arrangement, with three replicates per dilution, considering temperature fluctuations in the study area. The MPN at 95% confidence was 4.45x107 rhizobia g-1 of pumice at a 10-5 dilution for the Mexican biofertilizer, and 1.48x105 rhizobia g-1 of pumice at a 10-4 dilution for the Ecuadorian biofertilizer. The estimated optimal dilution for both products was 10-8.

https://doi.org/10.29393/chjaas40-7eber70007

Plasma Electrolytic Nitrocarburizing of SAE 1045: Electro-chemical Slurry Erosion Wear Analysis 1045 Electrochemical Electro chemical 104 10 1
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Noronha, Leandro Câmara

; Castro, Victor Velho de

; Schroeder, Roberto Moreira

; Mussulini, Leonardo

; Santos, Leonardo Moreira dos

; Andrade, Antonio Marcos Helgueira de

; Malfatti, Célia de Fraga

Materials Research

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2024, Volume 27 elocation e20230283

Resumo: En | Texto: En | PDF: En

Nitrocarburized coating by plasma electrolytic saturation, PEN/C coatings, have been proposed to increase the corrosion and wear resistance of steel by using a process of low-temperature hydrostatic plasma. The objective of this work is to analyse the wear and corrosion resistance of PEN/C coatings on SAE 1045 steel, using the electrochemical slurry erosion wear test (ESEWT). This test allows the evaluation of the simultaneous effect of erosion wear and electrochemical behaviour on this coating. Thus, it was possible to evaluate the erosive and corrosive effect and the synergy of these phenomena on the PEN/C coated SAE 1045 mass loss rates. ESEWT tests were performed at different times and under different electrochemical conditions: under cathodic protection and open circuit potential (OCP). The PEN/C coating increased the corrosion resistance of SAE 1045. Synergy between the erosive wear and corrosion was the main factor in the mass loss rates of both analysed systems. The synergistic mechanism of the substrate occurred by removing the corrosion product and by activating the surface generated by the erosive process of the particles. The synergistic mechanism of the PEN/C coating occurred with the removal of inherent surface irregularities through the erosive process, combined with localized corrosion. saturation PENC PEN C lowtemperature low temperature 104 ESEWT. . (ESEWT) Thus conditions OCP. OCP (OCP) systems particles 10 (ESEWT (OCP 1

https://doi.org/10.1590/1980-5373-mr-2023-0283

Checklist of the species of the Order Characiformes (Teleostei: Ostariophysi) Teleostei (Teleostei Ostariophysi
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Toledo-Piza, Mônica

; Baena, Eduardo G.

; Dagosta, Fernando C. P.

; Menezes, Naércio A.

; Ândrade, Marcelo

; Benine, Ricardo C.

; Bertaco, Vinicius A.

; Birindelli, José Luís O.

; Boden, Gert

; Buckup, Paulo A.

; Camelier, Priscila

; Carvalho, Fernando R. de

; Castro, Ricardo M. C.

; Chuctaya, Junior

; Decru, Eva

; Derijst, Eddy

; Dillman, Casey B.

; Ferreira, Katiane M.

; Merxem, Dimitri G.

; Giovannetti, Victor

; Hirschmann, Alice

; Jégu, Michel

; Jerep, Fernando C.

; Langeani, Francisco

; Lima, Flávio C. T.

; Lucena, Carlos A. S.

; Lucena, Zilda Margarete S.

; Malabarba, Luiz R.

; Malabarba, Maria Cláudia S. L.

; Marinho, Manoela M. F.

; Mathubara, Kleber

; Mattox, George M. T.

; Melo, Bruno F.

; Moelants, Tuur

; Moreira, Cristiano R.

; Musschoot, Tobias

; Netto-Ferreira, André L.

; Ota, Rafaela P.

; Oyakawa, Osvaldo T.

; Pavanelli, Carla S.

; Reis, Roberto E.

; Santos, Osmar

; Serra, Jane Piton

; Silva, Gabriel S. C.

; Silva-Oliveira, Cárlison

; Souza-Lima, Rosana

; Vari, Richard P.

; Zanata, Angela M.

Neotropical Ichthyology

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2024, Volume 22 Nº 1 elocation e230086

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract A checklist of recent and fossil fishes of the Order Characiformes is presented herein and believed to be complete through 2022. A total of 47 collaborators checked and provided information about their taxa of expertise. The list is arranged in alphabetical order by family and then genus and includes all available synonyms. From a total of 3,087 species group names and 527 genus group names, 2,334 species are currently treated as valid, and assigned to 301 genera and 24 families. This total includes 25 species known only from the fossil record, of which 21 are assigned to eight extant families and four are Incertae sedis in Characiformes, but does not include five species based on fossil which were wrongly treated in Characiformes. The status of 79 nominal species remains unresolved. When there are two competing hypotheses about the validity of a name, one of them is chosen and the alternate interpretation is provided in the remark section of that name. Distributional summaries are presented as numbers that correspond to areas for which there is a record of occurrence of the species. A list of unavailable names is provided at the end since some of those names may need additional research to certify their status. 2022 4 expertise synonyms 3087 3 087 3,08 52 2334 2 334 2,33 valid 30 7 unresolved name 202 308 08 3,0 5 233 33 2,3 20 0 3, 23 2,

Resumo Uma lista de peixes recentes e fósseis da Ordem Characiformes é apresentada e acredita-se que a lista esteja completa até 2022. Ao todo, 47 colaboradores verificaram e forneceram informações sobre táxons de sua especialidade. A lista está organizada em ordem alfabética por família e em seguida gênero e inclui todos os sinônimos disponíveis. De um total de 3.087 nomes de grupos de espécies e 527 nomes de grupos de gêneros, 2.334 espécies são atualmente tratadas como válidas e atribuídas a 301 gêneros e 24 famílias. Este total inclui 25 espécies fósseis, das quais 21 são incluídas em oito famílias recentes e quatro são Incertae sedis em Characiformes, mas não inclui cinco espécies baseadas em fósseis que foram incorretamente consideradas como Characiformes. O status de 79 espécies nominais permanece não resolvido. Quando há duas hipóteses concorrentes sobre a validade de um nome, uma delas é escolhida e a interpretação alternativa é fornecida na seção de comentários do nome em questão. Dados sobre distribuição geográfica são apresentados através de números que correspondem a regiões para as quais há registro de ocorrência da espécie. Uma lista de nomes indisponíveis foi listada no final do texto, pois alguns desses nomes precisam ser mais bem investigados para certificar seu status. acreditase acredita se 2022 todo 4 especialidade disponíveis 3087 3 087 3.08 52 2334 2 334 2.33 30 7 resolvido questão espécie texto 202 308 08 3.0 5 233 33 2.3 20 0 3. 23 2.

https://doi.org/10.1590/1982-0224-2023-0086

Disease progression in Sanfilippo type B: Case series of Brazilian patients B
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Montenegro, Yorran Hardman Araújo

; Kubaski, Francyne

; Trapp, Franciele Barbosa

; Riegel-Giugliani, Mariluce

; Souza, Carolina Fischinger Moura de

; Ribeiro, Erlane Marques

; Lourenço, Charles Marques

; Cardoso-dos-Santos, Augusto César

; Ribeiro, Márcia Gonçalves

; Kim, Chong Ae

; Castro, Matheus Augusto Araújo

; Embiruçu, Emília Katiane

; Steiner, Carlos Eduardo

; Vairo, Filippo Pinto e

; Baldo, Guilherme

; Giugliani, Roberto

; Poswar, Fabiano de Oliveira

Genetics and Molecular Biology

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2024, Volume 47 Nº 1 elocation e20230285

Resumo: En | Texto: En | PDF: En

Abstract Mucopolysaccharidosis type IIIB (MPS IIIB) is caused by deficiency of alpha-N-acetylglucosaminidase, leading to storage of heparan sulphate. The disease is characterized by intellectual disability and hyperactivity, among other neurological and somatic features. Here we studied retrospective data from a total of 19 MPS IIIB patients from Brazil, aiming to evaluate disease progression. Mean age at diagnosis was 7.2 years. Speech delay was one of the first symptoms to be identified, around 2-3 years of age. Behavioral alterations include hyperactivity and aggressiveness, starting around age four. By the end of the first decade, patients lost acquired abilities such as speech and ability to walk. Furthermore, as disease progresses, respiratory, cardiovascular and joint abnormalities were found in more than 50% of the patients, along with organomegaly. Most common cause of death was respiratory problems. The disease progression was characterized in multiple systems, and hopefully these data will help the design of appropriate clinical trials and clinical management guidelines. alphaNacetylglucosaminidase, alphaNacetylglucosaminidase alpha N acetylglucosaminidase, acetylglucosaminidase alpha-N-acetylglucosaminidase sulphate features 1 Brazil 72 7 2 7. identified 23 3 2- aggressiveness four decade walk Furthermore progresses 50 organomegaly problems systems guidelines 5

https://doi.org/10.1590/1678-4685-gmb-2023-0285

Clinical profile of vitiligo patients and relationship with immuno-inflammatory markers immunoinflammatory immuno inflammatory
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Mascarenhas, Marta Regina Machado

; Oliveira, Mariana de Castro

; Oliveira, Luise Fonseca de

; Magalhães, Andréa Santos

; Machado, Paulo Roberto Lima

Anais Brasileiros de Dermatologia

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2024, Volume 99 Nº 2 Páginas 196 - 201

Resumo: En | Texto: En | PDF: En

Abstract Background Vitiligo is the most common pigmentary disorder and is considered a chronic, cumulative, multifactorial disease. The crucial role of cytotoxic CD8+ T lymphocytes and the IFNγ/CXCL10 axis has been demonstrated in its pathogenesis. Objective To evaluate the clinical profile and immuno-inflammatory markers in patients with vitiligo in a reference medical center. Methods Cross-sectional study in which all patients with vitiligo seen at the medical center the from 2019 to 2022 were evaluated, to outline the clinical profile. Moreover, cardiovascular risk biomarkers (neutrophil/lymphocyte ratio and C-reactive protein levels) were measured, as well as cytokines and chemokines (TNFα, IFNγ, IL10, IL15 and CXCL10) in the serum of a subgroup of 30 patients. Results There was a predominance of females, with a mean age of 43 years. Most were phototypes IV or V (71.3%), without comorbidities (77.55%), and without a family history of vitiligo (70.41%). Higher levels of neutrophil/lymphocyte ratio, C-reactive protein, and inflammatory cytokines/chemokines were documented in vitiligo patients when compared to the control group (non-significant). As relevant data, the highest values of CXCL10 were detected in patients with vitiligo versus controls, as well as in patients with disease of shorter duration (p < 0.05). Study limitations The number of assessed patients was small due to recruitment difficulties caused by the COVID-19 pandemic. Conclusion The present data contribute to confirming the relevant role of the IFNγ/CXCL10 axis in the pathogenesis of vitiligo, highlighting CXCL10 as a possible activity marker. chronic cumulative CD8 CD IFNγCXCL10 IFNγCXCL IFNγ CXCL IFNγ/CXCL1 immunoinflammatory immuno Crosssectional Cross sectional 201 202 evaluated Moreover neutrophillymphocyte neutrophil lymphocyte Creactive C reactive measured TNFα, TNFα (TNFα IL10 IL IL1 3 females 4 years 71.3%, 713 71.3% , 71 (71.3%) 77.55%, 7755 77.55% 77 55 (77.55%) 70.41%. 7041 70.41% . 70 41 (70.41%) cytokineschemokines nonsignificant. nonsignificant non significant (non-significant) CXCL1 controls p 0.05. 005 0.05 0 05 0.05) COVID19 COVID 19 COVID-1 pandemic marker IFNγCXCL1 IFNγ/CXCL 20 71.3 7 (71.3% 775 77.55 5 (77.55% 704 70.41 (70.41% (non-significant 00 0.0 COVID1 1 COVID- 2 71. (71.3 77.5 (77.55 70.4 (70.41 0. (71. 77. (77.5 70. (70.4 (71 (77. (70. (7 (77 (70 (

https://doi.org/10.1016/j.abd.2023.03.007

10.

Anticandida and antibiofilm activities of extract from Schinopsis brasiliensis Engl. against Candida spp. Engl spp
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JOVITO, Vanessa de Carvalho

; LIMA, Jefferson Muniz de

; RANGEL, Marianne de Lucena

; GONDIM, Brenna Louise Cavalcanti

; NOGUEIRA, Paula Lima

; MEDEIROS, Ana Claúdia Dantas de

; SOBRAL, Marianna Vieira

; CASTRO, Ricardo Dias de

; CASTELLANO, Lúcio Roberto Cançado

Brazilian Oral Research

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2024, Volume 38 elocation e016

Resumo: En | Texto: En | PDF: En

Abstract The pathogenic nature of infections caused by Candida spp. underscores the necessity for novel therapeutic agents. Extracts of Schinopsis brasilienses Engl are \ a promising source of agents with antifungal effects. This study aimed to assess the antifungal potential of the leaf extract of S. brasilienses. The antifungal activity was evaluated by determining the minimum inhibitory concentrations and fungicide concentrations (MIC and MFC). The antibiofilm potential was assessed by counting colony-forming units/mL. The study examined the inhibition kinetics of fungal growth and potential synergism between gallic acid or the extract and nystatin using the Checkerboard method. Cytotoxicity was evaluated through the MTT assay. The extract exhibited antifungal effect against all tested strains, with MIC and MFC ranging from 31.25–250 μg/mL. Gallic acid, the main isolated compound, displayed a MIC of 2000 μg/mL. The extract of S. brasilienses at 31.25 μg/mL inhibited the formation of biofilm by C. albicans and significantly reduced the mass of mature biofilm after 24 and 48 h (p < 0. 05). At a concentration of 125 μg/mL, the extract demonstrated significant inhibition of fungal growth after 6 hours. The combination of gallic acid or extract with nystatin did not exhibit synergistic or antagonistic effect. Furthermore, the extract did not induce cytotoxicity to a human cell line. The extract of S. brasiliensis demonstrates antifungal activity against Candida, generally exhibiting fungicidal action and capacity to inhibit biofilm formation as well as reduce mature biofilms. Additionally, the extract showed low cytotoxicity to human cells. spp effects S MFC. . MFC) colonyforming colony forming unitsmL units mL units/mL method assay strains 3125250 31 25 250 31.25–25 μgmL μg compound 200 3125 31.2 C 2 4 p 0 05. 05 05) 12 hours Furthermore line biofilms Additionally cells 312525 3 31.25–2 20 312 31. 1 31252 31.25–

https://doi.org/10.1590/1807-3107bor-2024.vol38.0016

11.

IN SEARCH OF AN INTEGRATIVE FRAMEWORK FOR FEMALE IMMIGRANT ENTREPRENEURSHIP
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Cunha, Victoria Barboza de Castro

; Nascimento, Thiago Cavalcante

; Falcão, Roberto Pessoa de Queiroz

Revista de Administração de Empresas

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2024, Volume 64 Nº 1 elocation e2022-0469

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN El espíritu empresarial femenino (EEFEM) se ha presentado durante mucho tiempo como impulsado principalmente por la necesidad que abarca los procesos sociales de género que empujan a las mujeres a aventurarse como un medio para encontrar la independencia, la seguridad en sí mismas, el alivio financiero o un estilo de vida más equilibrado. La investigación existente también identificó diferencias en las motivaciones y barreras para el autoempleo femenino en países en desarrollo frente a países desarrollados. Por lo tanto, el artículo propone un marco integrador que combina el arraigo mixto y la teoría institucional para analizar el proceso empresarial de las mujeres inmigrantes, adoptando una lente multiteórica para profundizar la comprensión de las prácticas empresariales de las mujeres en el extranjero, abordando las inconsistencias del arraigo de Granovetter. EEFEM (EEFEM independencia mismas equilibrado desarrollados tanto inmigrantes extranjero Granovetter

ABSTRACT Female entrepreneurship (FENT) has long been presented as primarily driven by necessity, encompassing gendered social processes that push women into venturing to find independence, self-assurance, financial relief, or a more balanced lifestyle. Extant research also identified differences in motivations and barriers to female self-employment in developing versus developed countries. Thus, the article proposes an integrative framework combining Mixed Embeddedness and Institutional Theory to analyze immigrant women’s entrepreneurial process, adopting a multi-theoretical lens to deepen the understanding of women’s entrepreneurial practices, addressing Granovetter’s embeddedness’ inconsistencies. FENT (FENT necessity independence selfassurance, selfassurance self assurance, assurance self-assurance relief lifestyle selfemployment employment countries Thus womens s process multitheoretical multi theoretical practices Granovetters Granovetter embeddedness inconsistencies

RESUMO O empreendedorismo feminino (EFEM) vem sendo apresentado como impulsionado principalmente pela necessidade, abrangendo processos sociais de gênero que levam as mulheres a empreender como meio de encontrar independência, autoconfiança, alívio financeiro ou um estilo de vida mais equilibrado. Pesquisas existentes também identificaram diferenças nas motivações e barreiras ao autoemprego feminino em países em desenvolvimento versus países desenvolvidos. Assim, o artigo propõe um quadro integrador combinando a Imersão Mista e a Teoria Institucional para analisar o processo empreendedor das mulheres imigrantes, adotando uma lente multiteórica para aprofundar a compreensão das práticas empreendedoras das mulheres no exterior e sanar as inconsistências da imersão de Granovetter. EFEM (EFEM necessidade independência autoconfiança equilibrado desenvolvidos Assim imigrantes Granovetter

https://doi.org/10.1590/s0034-759020240101

12.

ARE THERE ADVANTAGES IN DOUBLE TRANSIT RECONSTRUCTION AFTER TOTAL GASTRECTOMY IN PATIENTS WITH GASTRIC CANCER? A SYSTEMATIC REVIEW CANCER
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COSTA, Luigi Carlo da Silva

; MACEDO, Ary Augusto de Castro

; ARAÚJO, Juliana Mattei de

; SILVA, Ewerton Lima da

; MORAES, Luís Felipe Gomes Reis de

; SANTOS, Aline dos

; SOARES, Hugo Gomes

; TERCIOTI JUNIOR, Valdir

; COELHO NETO, João de Souza

; ANDREOLLO, Nelson Adami

; LOPES, Luiz Roberto

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2024, Volume 37 elocation e1799

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT BACKGROUND: Curative treatment for gastric cancer involves tumor resection, followed by transit reconstruction, with Roux-en-Y being the main technique employed. To permit food transit to the duodenum, which is absent in Roux-en-Y, double transit reconstruction has been used, whose theoretical advantages seem to surpass the previous technique. AIMS: To compare the clinical evolution of gastric cancer patients who underwent total gastrectomy with Roux-en-Y and double tract reconstruction. METHODS: A systematic review was carried out on Web of Science, Scopus, EmbasE, SciELO, Virtual Health Library, PubMed, Cochrane, and Google Scholar databases. Data were collected until June 11, 2022. Observational studies or clinical trials evaluating patients submitted to double tract (DT) and Roux-en-Y (RY) reconstructions were included. There was no temporal or language restriction. Review articles, case reports, case series, and incomplete texts were excluded. The risk of bias was calculated using the Cochrane tool designed for randomized clinical trials. RESULTS: Four studies of good methodological quality were included, encompassing 209 participants. In the RY group, there was a greater reduction in food intake. In the DT group, the decrease in body mass index was less pronounced compared to preoperative values. CONCLUSIONS: The double tract reconstruction had better outcomes concerning body mass index and the time until starting a light diet; however, it did not present any advantages in relation to nutritional deficits, quality of life, and post-surgical complications. BACKGROUND resection RouxenY Roux en Y employed duodenum RouxenY, Y, used AIMS METHODS Science Scopus EmbasE SciELO Library PubMed databases 11 2022 (DT (RY included restriction articles reports series excluded RESULTS 20 participants group intake values CONCLUSIONS diet however deficits life postsurgical post surgical complications 1 202 2

RESUMO RACIONAL: O tratamento curativo do câncer gástrico envolve a ressecção do tumor, seguida de reconstrução do trânsito, sendo o Y-de-Roux a principal técnica empregada. Para permitir o trânsito alimentar para o duodeno, ausente em Y-de-Roux, tem-se utilizado a reconstrução de duplo trânsito, cujas vantagens teóricas parecem superar a técnica anterior. OBJETIVOS: Comparar a evolução clínica de pacientes com câncer gástrico submetidos à gastrectomia total com Y-de-Roux e reconstrução de duplo trânsito. MÉTODOS: Foi realizada uma revisão sistemática nas bases de dados: Web of Science, Scopus, Embase, Scielo, Biblioteca Virtual em Saúde, PubMed e Cochrane. Os dados foram coletados até 11 de junho de 2022. Foram incluídos estudos observacionais ou ensaios clínicos avaliando pacientes que utilizaram reconstruções de duplo trânsito (DT) e Y-de-Roux (RY). Não houve restrição temporal ou de idioma. Foram excluídos artigos de revisão, relatos de casos, séries de casos e aqueles com texto incompleto. O risco de viés foi calculado utilizando a ferramenta Cochrane desenvolvida para ensaios clínicos randomizados. RESULTADOS: Foram incluídos quatro estudos de boa qualidade metodológica, abrangendo 209 participantes. No grupo RY houve maior redução na ingestão alimentar. No grupo DT, a diminuição do índice de massa corporal (IMC) foi menos pronunciada em comparação aos valores pré-operatórios. CONCLUSÕES: A reconstrução de duplo trânsito apresentou melhores resultados em relação ao índice de massa corporal e ao tempo para início de dieta leve, porém não apresentou vantagens em relação aos déficits nutricionais, qualidade de vida e complicações pós-cirúrgicas. RACIONAL tumor YdeRoux Y Roux empregada duodeno YdeRoux, Roux, temse tem se anterior OBJETIVOS MÉTODOS Science Scopus Embase Scielo Saúde 1 2022 DT (DT RY. . (RY) idioma incompleto randomizados RESULTADOS metodológica 20 participantes IMC (IMC préoperatórios. préoperatórios pré operatórios. operatórios pré-operatórios CONCLUSÕES leve nutricionais póscirúrgicas. póscirúrgicas pós cirúrgicas. cirúrgicas pós-cirúrgicas 202 (RY 2

https://doi.org/10.1590/0102-672020240006e1799

13.

Diretrizes da Sociedade Brasileira de Angiologia e de Cirurgia Vascular sobre o pé diabético 2023 202 20 2
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Duarte Junior, Eliud Garcia

; Lopes, Cicero Fidelis

; Gaio, Danilo Roberto Fadel

; Mariúba, Jamil Victor de Oliveira

; Cerqueira, Lorena de Oliveira

; Manhanelli Filho, Marcos Antonio Bonacorso

; Navarro, Tulio Pinho

; Castro, Aldemar Araújo

; Araujo, Walter Jr. Boim de

; Pedrosa, Hermelinda

; Galli Filho, Júnio

; Luccia, Nelson de

; Paula, Clayton de

; Reis Neto, Fernando

; Bohatch Júnior, Milton Sérgio

; Oliveira, Tércio Ferreira de

; Silva, Amanda Fernandes Vidal da

; Oliveira, Júlio Cesar Peclat de

; Joviliano, Edwaldo Édner

Jornal Vascular Brasileiro

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2024, Volume 23 elocation e20230087

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The diabetic foot interacts with anatomical, vascular, and neurological factors that challenge clinical practice. This study aimed to compile the primary scientific evidence based on a review of the main guidelines, in addition to articles published on the Embase, Lilacs, and PubMed platforms. The European Society of Cardiology system was used to develop recommendation classes and levels of evidence. The themes were divided into six chapters (Chapter 1 - Prevention of foot ulcers in people with diabetes; Chapter 2 - Pressure relief from foot ulcers in people with diabetes; Chapter 3 -Classifications of diabetic foot ulcers; Chapter 4 - Foot and peripheral artery disease; Chapter 5 - Infection and the diabetic foot; Chapter 6 - Charcot's neuroarthropathy). This version of the Diabetic Foot Guidelines presents essential recommendations for the prevention, diagnosis, treatment, and follow-up of patients with diabetic foot, offering an objective guide for medical practice. anatomical vascular practice guidelines Embase Lilacs platforms diabetes Classifications disease Charcots Charcot s neuroarthropathy. neuroarthropathy . neuroarthropathy) prevention diagnosis treatment followup follow up

Resumo O pé diabético corresponde a uma interação entre fatores anatômicos, vasculares e neurológicos que representam um desafio na prática clínica. O objetivo deste trabalho foi compilar as principais evidências científicas com base em uma revisão das principais diretrizes, além de artigos publicados nas plataformas Embase, Lilacs e PubMed. O sistema da Sociedade Européia de Cardiologia foi utilizado para desenvolver classes de recomendação e níveis de evidência. Os temas foram divididos em seis capítulos (Capítulo 1-Prevenção de úlceras nos pés de pessoas com diabetes; Capítulo 2-Alívio da pressão de úlceras nos pés de pessoas com diabetes; Capítulo 3-Classificações das úlceras do pé diabético; Capítulo 4-Pé diabético e a doença arterial periférica; Capítulo 5-Infecção e o pé diabético; Capítulo 6-Neuroartropatia de Charcot). A versão atual das Diretrizes sobre pé diabético apresenta importantes recomendações para prevenção, diagnóstico, tratamento e seguimento dos pacientes com pé diabético, oferecendo um guia objetivo para prática médica. anatômicos clínica diretrizes Embase PubMed evidência 1Prevenção Prevenção 1 diabetes 2Alívio Alívio 2 3Classificações Classificações 3 4Pé Pé 4 periférica 5Infecção Infecção 5 6Neuroartropatia Neuroartropatia 6 Charcot. Charcot . Charcot) prevenção diagnóstico médica

https://doi.org/10.1590/1677-5449.202300871

14.

Tinea corporis intrafamilial infection in pets due to Microsporum canis
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Sierra-Maeda, Karla Yaeko

; Martínez-Hernández, Fernando

; Arenas, Roberto

; Boeta-Ángeles, Leticia

; Martínez-Chavarría, Luary Carolina

; Rodríguez-Colín, Sonia Fabiola

; Xicohtencatl-Cortes, Juan

; Hernández-Castro, Rigoberto

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e30

Resumo: En | Texto: En | PDF: En

ABSTRACT Microsporum canis, one of the most widespread dermatophytes worldwide, is a zoonotic microorganism that transmits infection from reservoirs such as cats and dogs to humans. This microorganism is associated with Tinea corporis and other clinical manifestations; however, few studies have used genetic surveillance to determine and characterize the process of zoonotic transmission. In this study, we show a clear example of zoonotic transmission from a cat to an intrafamilial environment, where it caused Tinea corporis by infection with M. canis. Molecular characterization using the b-tubulin gene and Random Amplified Polymorphic DNA analysis made it possible to determine that the six isolates of M. canis obtained in this study belonged to the same genetic variant or clone responsible for reservoir-reservoir or reservoir-human transmission. worldwide humans manifestations however environment M btubulin b tubulin reservoirreservoir reservoir reservoirhuman human

https://doi.org/10.1590/s1678-9946202466030

15.

PERFIL VOLÁTIL DO Coffea arabica E Coffea canephora var. conilon POR SHS-GC-MS E QUIMIOMETRIA var SHSGCMS SHS GC MS
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Lyrio, Marcos Valério Vieira

; Cunha, Pedro Henrique Pereira da

; Debona, Danieli Grancieri

; Agnoletti, Bárbara Zani

; Frinhani, Roberta Quintino

; Oliveira, Emanuele Catarina da Silva

; Filgueiras, Paulo Roberto

; Pereira, Lucas Louzada

; Castro, Eustáquio Vinicius Ribeiro de

Química Nova

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2024, Volume 47 Nº 5 elocation e-20230130

Resumo: Pt | Texto: Pt | PDF: Pt

The volatile composition of coffee exerts a substantial influence on its quality, as it defines the characteristics of the beverage. However, these compounds are influenced by factors within the coffee production chain, such as botanical origin, geography, processing methods, and roasting. Consequently, the identification of such compounds becomes a vital tool for characterizing coffees to these factors. In this context, gas chromatography with headspace extraction is widely used for aroma analysis, providing a composition closer to consumer perception. Headspace extraction offers speed, simplicity, minimal sample preparation, and no need for solvents. In this study, static headspace extraction (SHS) coupled with gas chromatography-mass spectrometry (SHS-GC-MS) was employed to establish the chemical profile of volatile compounds in Coffea arabica and Coffea canephora var. conilon and determine discriminants between the species. A total of 97 compounds, belonging to 17 chemical classes, were identified. The chemometric analysis highlighted furans, phenols, and carboxylic acids as key differentiating classes. Notably, furfuryl alcohol, acetic acid, 4-vinylguaiacol, N-acetyl-4(H)-pyridine, and N-furfurylpyrrole emerged as crucial volatile compounds. The variable selection using Fisher weight applied directly in the chromatograms, produced models consistent with relative area data, with furfuryl alcohol and 4-vinylguaiacol regions being particularly influential in differentiation. quality beverage However chain origin geography methods roasting Consequently context perception speed simplicity preparation solvents study SHS (SHS chromatographymass mass SHSGCMS GC MS (SHS-GC-MS var species 9 1 classes identified furans phenols Notably acid 4vinylguaiacol, 4vinylguaiacol vinylguaiacol 4 vinylguaiacol, Nacetyl4Hpyridine, Nacetyl4Hpyridine NacetylHpyridine N acetyl H pyridine, pyridine N-acetyl-4(H)-pyridine Nfurfurylpyrrole furfurylpyrrole chromatograms data differentiation Nacetyl Hpyridine

https://doi.org/10.21577/0100-4042.20230130

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