ABSTRACT Purpose: This study aimed to determine whether early-stage intraocular pressure can be modulated using a thermal face mask. Methods: In this prospective clinical study, healthy participants were randomized on a 1:1:1 allocation ratio to three mask groups: hypothermic (G1), normothermic (G2), and hyperthermic (G3). After randomization, 108 eyes from 108 participants were submitted to clinical evaluations, including measurement of initial intraocular pressure (T1). The thermal mask was then applied for 10 minutes, followed by a second evaluation of intraocular pressure (T2) and assessment of any side effects. Results: The hypothermic group (G1) showed a significant reduction in mean intraocular pressure between T1 (16.97 ± 2.59 mmHg) and T2 (14.97 ± 2.44 mmHg) (p<0.001). G2 showed no significant pressure difference between T1 (16.50 ± 2.55 mmHg) and T2 (17.00 ± 2.29 mmHg) (p=0.054). G3 showed a significant increase in pressure from T1 (16.53 ± 2.69 mmHg) to T2 (18.58 ± 2.95 mmHg) (p<0.001). At T1, there was no difference between the three study groups (p=0.823), but at T2, the mean values of G3 were significantly higher than those of G1 and G2 (p<0.00). Conclusion: Temperature was shown to significantly modify intraocular pressure. Thermal masks allow the application of temperature in a controlled, reproducible manner. Further studies are needed to assess the duration of these effects and whether they are reproducible in patients with pathologies that affect intraocular pressure. Purpose earlystage early stage Methods 111 1 1:1: G1, G , G2, (G2) G3. . (G3) randomization evaluations T1. T (T1) minutes (T2 Results (G1 16.97 1697 16 97 (16.9 259 2 59 2.5 mmHg 14.97 1497 14 (14.9 244 44 2.4 p<0.001. p0001 p p<0.001 0 001 (p<0.001) 16.50 1650 50 (16.5 255 55 17.00 1700 17 00 (17.0 229 29 2.2 p=0.054. p0054 p=0.054 054 (p=0.054) 16.53 1653 53 269 69 2.6 18.58 1858 18 58 (18.5 295 95 2.9 p=0.823, p0823 p=0.823 823 (p=0.823) p<0.00. p000 p<0.00 (p<0.00) Conclusion controlled manner 11 1:1 (G2 (G3 (T1 (T (G 16.9 169 9 (16. 25 5 2. 14.9 149 (14. 24 4 (p<0.001 16.5 165 17.0 170 (17. 22 p005 p=0.05 05 (p=0.054 26 6 18.5 185 (18. p082 p=0.82 82 (p=0.823 p00 p<0.0 (p<0.00 1: 16. (16 14. (14 17. (17 p=0.0 (p=0.05 18. (18 p08 p=0.8 8 (p=0.82 p0 p<0. (p<0.0 (1 p=0. (p=0.0 (p=0.8 p<0 (p<0. ( p=0 (p=0. p< (p<0 p= (p=0 (p< (p= (p

Abstract To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety. date disease reallife real life attacks vasoocclusive vaso occlusive events syndrome transfusion which part physicians physician s report safety

ABSTRACT Objective: To describe the incidence and to analyze risk factors associated with cholestasis in neonates with gastroschisis. Methods: This is a retrospective cohort study in a tertiary single center analyzing 181 newborns with gastroschisis between 2009 and 2020. The following risk factors associated with cholestasis were analyzed: gestational age, birth weight, type of gastroschisis, silo closure or immediate closure, days of parenteral nutrition, type of lipid emulsion, days of fasting, days to reach a full diet, days with central venous catheter, presence of infections, and outcomes. Results: Among the 176 patients evaluated, 41 (23.3%) evolved with cholestasis. In the univariate analysis, low birth weight (p=0.023), prematurity (p<0.001), lipid emulsion with medium-chain triglycerides and long-chain triglycerides (p=0.001) and death (p<0.001) were associated with cholestasis. In the multivariate analysis, patients who received lipid emulsion with fish oil instead of medium chain triglycerides/long chain triglycerides (MCT/LCT) emulsion had a lower risk of cholestasis. Conclusions: Our study shows that lipid emulsion with fish oil is associated with a lower risk of cholestasis in neonates with gastroschisis. However, this is a retrospective study and a prospective study should be performed to confirm the results. Objective Methods 18 200 2020 analyzed age nutrition fasting diet catheter infections outcomes Results 17 evaluated 4 23.3% 233 23 3 (23.3% analysis p=0.023, p0023 p p=0.023 , 0 023 (p=0.023) p<0.001, p0001 p<0.001 001 mediumchain longchain long p=0.001 (p=0.001 (p<0.001 triglycerideslong MCT/LCT MCTLCT MCT LCT (MCT/LCT Conclusions However results 1 20 202 23.3 2 (23.3 p002 p=0.02 02 (p=0.023 p000 p<0.00 00 p=0.00 (p=0.00 (p<0.00 23. (23. p00 p=0.0 (p=0.02 p<0.0 (p=0.0 (p<0.0 (23 p0 p=0. p<0. (p=0. (p<0. (2 p=0 p<0 (p=0 (p<0 ( p= p< (p= (p< (p

RESUMO Objetivo: Analisar a incidência e os fatores de risco associados à colestase em recém-nascidos com gastrosquise. Métodos: Estudo de coorte retrospectivo em um único centro terciário, que analisou 181 recém-nascidos com gastrosquise entre 2009 e 2020. Foram examinados os seguintes fatores de risco associados à colestase: idade gestacional, peso ao nascer, tipo de gastrosquise, fechamento com silo ou fechamento imediato, dias de uso nutrição parenteral, tipo de emulsão lipídica, dias de jejum, dias para atingir a dieta completa, dias com cateter venoso central, presença de infecções e desfechos. Resultados: Dos 176 pacientes avaliados, 41 (23,3%) evoluíram com colestase. Baixo peso ao nascer (p=0,023), prematuridade (p<0,001), emulsão lipídica com triglicerídeos de cadeia média e triglicerídeos de cadeia longa (p=0,001) e óbito (p<0,001) foram associados à colestase. Na análise multivariada, os pacientes que receberam emulsão lipídica com óleo de peixe em vez da emulsão diária de triglicérides de cadeia média/triglicérides de cadeia longa (MCT/LCT) apresentaram menor risco de colestase. Conclusões: Nosso estudo mostra que a emulsão lipídica com óleo de peixe está associada a menor risco de colestase em neonatos com gastrosquise, porém este é um estudo retrospectivo, e um estudo prospectivo deve ser realizado para confirmar os resultados. Objetivo recémnascidos recém nascidos Métodos terciário 18 200 2020 gestacional imediato parenteral jejum completa central desfechos Resultados 17 avaliados 4 23,3% 233 23 3 (23,3% p=0,023, p0023 p p=0,023 , 0 023 (p=0,023) p<0,001, p0001 p<0,001 001 p=0,001 (p=0,001 (p<0,001 multivariada médiatriglicérides MCT/LCT MCTLCT MCT LCT (MCT/LCT Conclusões resultados 1 20 202 23,3 2 (23,3 p002 p=0,02 02 (p=0,023 p000 p<0,00 00 p=0,00 (p=0,00 (p<0,00 23, (23, p00 p=0,0 (p=0,02 p<0,0 (p=0,0 (p<0,0 (23 p0 p=0, p<0, (p=0, (p<0, (2 p=0 p<0 (p=0 (p<0 ( p= p< (p= (p< (p

ABSTRACT Objective: This study analyzed the impact of sex on self-reported health and lifestyle parameters in peripheral artery disease patients at two periods of the COVID-19 pandemic. Methods: In this longitudinal study, 99 patients with peripheral artery disease (53 men and 46 women) were evaluated during two periods of the COVID-19 pandemic ( i.e ., at onset: May to August 2020, and on follow-up: May to August 2021). Patients were interviewed via telephone, and information regarding lifestyle and health parameters was obtained. Results: At the onset of the COVID-19 pandemic, health and habit parameters were similar between women and men, with 63.0% and 45.3% indicating frequent fatigue, 73.9% and 84.9% reporting increased sitting time, and 23.9% and 39.6% practicing physical activity, respectively. At follow-up, difficulties in physical mobility (women: from 26.1% to 73.9%, p<0.001; men: from 39.6% to 71.7%, p=0.001) and the frequency of hospitalization for reasons other than COVID-19 increased similarly in women and men (women: from 4.3% to 21.7%, p=0.013; men: from 9.4% to 24.5%, p=0.038). The other parameters were similar between the periods. Conclusion: Self-reported physical mobility difficulties and hospitalization frequency increased in women and men with peripheral artery disease. Objective selfreported self reported COVID19 COVID 19 COVID-1 Methods 9 53 (5 4 ie i e . 2020 followup follow up follow-up 2021. 2021 2021) telephone obtained Results 630 63 0 63.0 453 45 3 45.3 fatigue 739 73 73.9 849 84 84.9 time 239 23 23.9 396 39 6 39.6 activity respectively followup, up, (women 261 26 1 26.1 p<0.001 p0001 p 001 717 71 7 71.7% p=0.001 43 4.3 217 21 21.7% p=0.013 p0013 013 94 9.4 245 24 5 24.5% p=0.038. p0038 p=0.038 038 p=0.038) Conclusion Selfreported Self COVID1 COVID- 202 63. 45. 73. 8 84. 2 23. 39. 26. p<0.00 p000 00 71.7 p=0.00 4. 21.7 p=0.01 p001 01 9. 24.5 p003 p=0.03 03 20 p<0.0 p00 71. p=0.0 21. 24. p<0. p0 p=0. p<0 p=0 p< p=

Resumen Objetivo Analizar las evidencias disponibles en la literatura acerca del fracaso de la inducción del trabajo de parto con misoprostol en gestaciones a término. Métodos Revisión integradora, realizada entre enero y noviembre de 2022, cuya pregunta de investigación y descriptores fueron definidos mediante la estrategia PECO. Las búsquedas fueron realizadas en las bases de datos MEDLINE, Web of Science, CINAHL, EMBASE y Scopus por dos investigadoras de forma independiente, al igual que la evaluación. Para la fase de selección e identificación de los estudios se utilizó el Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). La evaluación del riesgo de sesgo de los artículos incluidos se realizó a través del cuestionario Newcastle Ottawa Scale. Resultados Se identificaron 3.674 artículos, 84 se leyeron en su totalidad, de los cuales 11 conformaron la revisión (n=9.010 mujeres embarazadas), publicados entre los años 2005 y 2021, la mayoría en Estados Unidos. Respecto al nivel de evidencia, todos los artículos fueron clasificados como 2b, evaluada de acuerdo con el diseño de cada investigación. El estudio indicó evidencias respecto a los siguientes factores: IMC elevado (mayor igual a 30 kg/m2), nuliparidad, bishop bajo, longitud cervical (mayor o igual a 30 mm), estatura, etnia (no caucasoide del sur de Europa) y peso fetal (mayor igual a 4 kg). Conclusión Se alcanzó el objetivo del estudio y se demostraron seis factores maternos y uno fetal que pueden llevar al fracaso de la inducción. Cabe resaltar la necesidad de evidencias que incorporen la individualidad de cada característica y se destaca la contribución de este estudio para fundamentar la elección de la mejor conducta en cada gestación de forma individualizada. término integradora 2022 PECO MEDLINE Science CINAHL independiente MetaAnalyses Meta Analyses PRISMA. PRISMA . (PRISMA) Scale 3674 3 674 3.67 8 totalidad 1 n=9.010 n9010 n 9 010 (n=9.01 embarazadas, embarazadas , embarazadas) 200 2021 Unidos evidencia 2b b mayor kg/m2, kgm2 kgm kg/m2 kg m2 m kg/m2) nuliparidad bajo mm, mm mm) estatura no Europa kg. kg) individualizada 202 (PRISMA 367 67 3.6 n=9.01 n901 01 (n=9.0 20 kg/m 36 6 3. n=9.0 n90 0 (n=9. 2 n=9. n9 (n=9 n=9 (n= n= (n

Abstract Objective To analyze the evidence available in literature regarding unsuccessful labor induction with misoprostol in full-term pregnancies. Methods This is an integrative review, carried out between January and November 2022, whose research question and descriptors were outlined using the PECO strategy. The searches were carried out in the MEDLINE, Web of Science, CINAHL, EMBASE and Scopus databases by two researchers independently as well as assessment. For the study selection and identification phase, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was used. The risk of bias assessment of included articles was carried out using the Newcastle-Ottawa Scale. Results A total of 3,674 articles were identified, and 84 were read in full, of which 11 comprised the review (n=9,010 pregnant women), published between 2005 and 2021, with the majority in the United States. Regarding the level of evidence, all articles were classified as 2b, assessed according to the design of each study. The study showed evidence regarding the following factors: High BMI (greater than 30 kg/m2), nulliparity, immature bishop, cervical length (greater than 30 mm), height, ethnicity (non-Caucasians from southern Europe) and fetal weight (greater equal to 4 kg). Conclusion The objective study was achieved, having demonstrated six maternal factors and one fetal factor that can lead to unsuccessful induction. It is worth highlighting the need for evidence that incorporates the individuality of each characteristic and the contribution of this study to support the choice of the best conduct for each pregnancy on an individual basis stands out. fullterm full term pregnancies 2022 strategy MEDLINE Science CINAHL phase MetaAnalyses Meta Analyses PRISMA (PRISMA used NewcastleOttawa Newcastle Ottawa Scale 3674 3 674 3,67 identified 8 1 n=9,010 n9010 n 9 010 (n=9,01 women, women , women) 200 2021 States 2b b greater kg/m2, kgm2 kgm kg/m2 kg m2 m kg/m2) nulliparity bishop mm, mm mm) height nonCaucasians non Caucasians Europe kg. . kg) achieved 202 367 67 3,6 n=9,01 n901 01 (n=9,0 20 kg/m 36 6 3, n=9,0 n90 0 (n=9, 2 n=9, n9 (n=9 n=9 (n= n= (n

Resumo Objetivo Analisar as evidências disponíveis na literatura acerca do insucesso da indução do trabalho de parto com misoprostol em gestações a termo. Métodos Revisão integrativa, realizada entre janeiro e novembro de 2022, cuja pergunta de pesquisa e descritores foram delineados por meio da estratégia PECO. As buscas foram realizadas nas bases de dados MEDLINE; Web of Science; CINAHL; EMBASE e Scopus por duas pesquisadoras de forma independente, assim como a avaliação. Para a fase de seleção e identificação dos estudos foi utilizado o Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A avaliação do risco de viés dos artigos incluídos foi realizada através do questionário Newcastle Ottawa Scale. Resultados Foram identificados 3.674 artigos, 84 foram lidos na íntegra, dos quais 11 compuseram a revisão (n=9.010 gestantes), com publicação entre os anos de 2005 a 2021, sendo a maioria nos Estados Unidos. Quanto ao nível de evidência, todos os artigos foram classificados como 2b, avaliada coforme o delineamento de cada investigação. O estudo apontou evidências quanto aos seguintes fatores: IMC elevado (maior igual a 30kg/m2), nuliparidade, bishop imaturo, comprimento cervical (maior igual a 30mm), estatura, etnia (não caucasianas do sul da Europa) e peso fetal (maior igual a 4kg). Conclusão Alcançou-se o objetivo do estudo tendo sido demonstrado seis fatores maternos e um fetal que podem levar ao insucesso da indução. Vale ressaltar a necessidade de evidências que incorporem a individualidade de cada característica e destaca-se a contribuição desse estudo para embasar a escolha da melhor conduta para cada gestação de forma individualizada. termo integrativa 2022 PECO MEDLINE Science CINAHL independente MetaAnalyses Meta Analyses PRISMA. PRISMA . (PRISMA) Scale 3674 3 674 3.67 8 íntegra 1 n=9.010 n9010 n 9 010 (n=9.01 gestantes, gestantes , gestantes) 200 2021 Unidos evidência 2b b investigação maior 30kg/m2, 30kgm2 kgm 30kg/m2 30kg m2 kg m 30kg/m2) nuliparidade imaturo 30mm, 30mm mm 30mm) estatura não Europa 4kg. 4kg 4kg) Alcançouse Alcançou se destacase destaca individualizada 202 (PRISMA 367 67 3.6 n=9.01 n901 01 (n=9.0 20 30kgm 30kg/m 36 6 3. n=9.0 n90 0 (n=9. 2 n=9. n9 (n=9 n=9 (n= n= (n

Abstract Microsatellites have been widely used to genotype individuals and to address a myriad of biological questions in many research fields for decades. However, when implementing a microsatellite marker analysis routine from scratch, various problems can arise throughout the process from DNA extraction to allele scoring, including inputting errors in the database, decreasing the reliability of results and having profound negative impacts on the derived decisions. Therefore, correctly assigning a genotype to a sample is crucial and dependent on acquiring knowledge of the technique steps, such as the chemistry of reactions, software, and data curation. This study tested two previously constructed simple sequence repeat (SSR) sets containing ten primer pairs each (ten-plex) in 1142 maize genotypes. Here, we describe the challenges faced when implementing this microsatellite-based genotyping protocol in our laboratory and possible ways to overcome them, hopefully aiding other novice research teams in this field. decades However scratch scoring database decisions Therefore steps reactions software curation SSR (SSR tenplex plex (ten-plex 114 genotypes Here microsatellitebased based them field 11 1

This study was carried out as a preliminary mapping of Maillard reaction (MR) compounds in doce de leite (DL), as possible indicators for the intermediate stage and chemical pathways in industrial processing. For that, the objective of the manuscript was to developed and validated an analytical method to simultaneously analyze four furfural compounds in DL: 5-hydroxymethylfurfural, 2-furaldehyde (F), 2-furyl-methyl ketone (FMC) and 5-methyl-2-furaldehyde (MF) by high performance liquid chromatography-photodiode-array detector (HPLC-PDA). The method fulfilled the acceptance criteria: selectivity, linearity (0.16-5 μg mL-1 for HMF, and 0.06-2 μg mL-1 for F, FMC and MF, R2 > 0.9974), precision (CV = 1.33 to 2.12% for HMF; 1.57 to 4.34% for F; 0.84 to 1.40% for FMC and 1.40 to 4.18% for MF), accuracy (94.40 to 102.25% for HMF; 92.91 to 108.15% for F; 90.13 to 108.48% for FMC and 93.31 to 107.70% for MF), limit of detection of 0.041 μg mL-1 for HMF; 0.030 μg mL-1 for F; 0.042 μg mL-1 for FMC and MF, and limit of quantification of 0.125 μg mL-1 for HMF and F, 0.066 μg mL-1 for FMC and 0.1280 μg mL-1 for MF. Thus, it was concluded that an analytical method was developed and validated for quantifying HMF, F, FMC and MF in DL. MR (MR DL, DL , (DL) processing 5hydroxymethylfurfural, 5hydroxymethylfurfural hydroxymethylfurfural 5 hydroxymethylfurfural, 5-hydroxymethylfurfural 2furaldehyde furaldehyde 2 F (F) 2furylmethyl furylmethyl furyl methyl (FMC 5methyl2furaldehyde methylfuraldehyde (MF chromatographyphotodiodearray chromatography photodiode array HPLCPDA. HPLCPDA HPLC PDA . (HPLC-PDA) criteria selectivity 0.165 0165 0.16 0 16 (0.16- mL1 mL 1 mL- 0.062 0062 0.06 06 0.06- R 0.9974, 09974 0.9974 9974 0.9974) CV 133 33 1.3 212 12 2.12 157 57 1.5 434 4 34 4.34 084 84 0.8 140 40 1.4 418 18 4.18 MF) 94.40 9440 94 (94.4 10225 102 25 102.25 9291 92 91 92.9 10815 108 15 108.15 9013 90 13 90.1 10848 48 108.48 9331 93 31 93.3 10770 107 70 107.70 0041 041 0.04 0030 030 0.03 0042 042 0125 125 0.12 0066 066 01280 1280 0.128 Thus (DL (F (HPLC-PDA 165 016 0.1 (0.16 062 006 0.0 0997 0.997 997 3 1. 21 2.1 43 4.3 08 8 0. 14 41 4.1 94.4 944 9 (94. 1022 10 102.2 929 92. 1081 108.1 901 90. 1084 108.4 933 93. 1077 7 107.7 004 04 003 03 012 0128 128 01 (0.1 00 099 0.99 99 2. 4. 94. (94 102. 108. 107. (0. 09 0.9 (9 (0 (

Abstract We developed poly-ε-caprolactone (PCL)-based nanoparticles containing D-α-tocopherol polyethylene glycol-1000 succinate (TPGS) or Poloxamer 407 as stabilizers to efficiently encapsulate genistein (GN). Two formulations, referred to as PNTPGS and PNPol, were prepared using nanoprecipitation. They were characterized by size and PDI distribution, zeta potential, nanoparticle tracking analysis (NTA), GN association (AE%), infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC). PNTPGS-GN exhibited a particle size of 141.2 nm, a PDI of 0.189, a zeta potential of -32.9 mV, and an AE% of 77.95%. PNPol-GN had a size of 146.3 nm, a better PDI than PNTPGS-GN (0.150), a less negative zeta potential (-21.0 mV), and an AE% of 68.73%. Thermal and spectrometric analyses indicated that no new compounds were formed, and there was no incompatibility detected in the formulations. Cellular studies revealed that Poloxamer 407 conferred less toxicity to PCL nanoparticles. However, the percentage of uptake decreased compared to the use of TPGS, which exhibited almost 80% cellular uptake. This study contributes to the investigation of stabilizers capable of conferring stability to PCL nanoparticles efficiently encapsulating GN. Thus, the PCL nanoparticle proposed here is an innovative nanomedicine for melanoma therapy and represents a strong candidate for specific pre-clinical and in vivo studies. polyεcaprolactone poly ε caprolactone PCLbased based Dαtocopherol D α tocopherol glycol1000 glycol 1000 glycol-100 TPGS (TPGS 40 . (GN) formulations PNPol nanoprecipitation distribution NTA, NTA , (NTA) AE%, AE (AE%) FTIR, FTIR FT IR (FT-IR) DSC. DSC (DSC) PNTPGSGN 1412 141 2 141. nm 0189 0 189 0.189 32.9 329 32 9 -32. mV 7795 77 95 77.95% PNPolGN 1463 146 3 146. 0.150, 0150 0.150 150 (0.150) 21.0 210 21 (-21. mV) 6873 68 73 68.73% formed However 80 Thus preclinical pre clinical glycol100 100 glycol-10 4 (GN (NTA (AE% (FT-IR (DSC 14 018 18 0.18 32. -32 779 7 77.95 015 0.15 15 (0.150 21. (-21 687 6 68.73 8 glycol10 10 glycol-1 (AE 1 01 0.1 -3 77.9 (0.15 (-2 68.7 glycol1 glycol- 0. - 77. (0.1 (- 68. (0. ( (0

Resumen Este estudio buscó expandir la discusión sobre la extensión en que el turismo puede responder a las expectativas socioeconómicas. Como en otras zonas costeras, el estado de Alagoas ha priorizado la promoción turística, pese a la ocurrencia de una estación lluviosa que frena el desarrollo de su principal tipo de turismo, de sol y playa. En este contexto, clima y tiempo son utilizados como puntos de referencia para este análisis. Por intermedio de diversas fuentes, se identificaron nueve narrativas sobre la estación lluviosa. Al cruzarlas con el Plan Estratégico para el Desarrollo Turístico de Alagoas 2013-2023, los resultados destacaron cómo la estación lluviosa está mal reflejada en dicha política pública. Para mejor abordar las limitaciones y demandas locales-regionales actuales, son propuestas recomendaciones. Más allá de esto, el abordaje de las narrativas probó su utilidad para expandir la consideración de valores y significados en políticas públicas, potencialmente en la relación ambiente-sociedad. socioeconómicas costeras turística playa contexto análisis fuentes 20132023, 20132023 2013 2023, 2023 2013-2023 pública localesregionales locales regionales actuales recomendaciones esto públicas ambientesociedad. ambientesociedad ambiente sociedad. sociedad ambiente-sociedad 2013202 201 202 2013-202 201320 20 2013-20 20132 2 2013-2 2013-

Abstract This study aims to expand the discussion regarding the extent to which tourism can address socioeconomic expectations. Like other coastal regions, the state of Alagoas has prioritised tourism promotion, despite facing a rainy season that hinders its primary form of tourism, known as Sea, Sun and Sand tourism. We have based our assessment on climate and weather. Through various sources, we have identified narratives related to the rainy season. When crossing these narratives with the Alagoas Strategic Plan for Tourism Development 2013-2023, our findings revealed that the state’s policy inadequately addresses the impact of the rainy season. Consequently, we have proposed some recommendations to better align with current local-regional constraints and demands. Beyond the scope of this work, our narrative approach has proven valuable in expanding the consideration of values and meanings within the framework of public policy development, potentially fostering a more holistic understanding of the environment-society relationship. expectations regions promotion Sea weather sources 20132023, 20132023 2013 2023, 2023 2013-2023 states s Consequently localregional local regional demands work development environmentsociety environment society relationship 2013202 201 202 2013-202 201320 20 2013-20 20132 2 2013-2 2013-

Resumo Esse estudo busca ampliar a discussão sobre a extensão na qual o turismo pode responder às expectativas socioeconômicas. Como em outras zonas costeiras, o estado de Alagoas tem priorizado a promoção turística, apesar da ocorrência de uma estação chuvosa que freia o desenvolvimento do seu principal tipo de turismo, de sol e praia. Neste contexto, o clima e o tempo são utilizados como pontos de referência para essa análise. Por intermédio de diversas fontes, foram identificadas nove narrativas relacionadas à estação chuvosa. As narrativas foram cruzadas com o Plano Estratégico para o Desenvolvimento Turístico de Alagoas 2013-2023, apontando que a estação chuvosa está mal refletida na política estadual. Para melhor abordar as limitações e demandas locais-regionais atuais, recomendações foram, assim, propostas. Além do escopo desse trabalho, a abordagem das narrativas provou ser útil para ampliar a consideração de valores e significados no desenvolvimento de políticas públicas, especialmente na relação ambiente-sociedade. socioeconômicas costeiras turística praia contexto análise fontes 20132023, 20132023 2013 2023, 2023 2013-2023 estadual locaisregionais locais regionais atuais assim propostas trabalho públicas ambientesociedade. ambientesociedade ambiente sociedade. sociedade ambiente-sociedade 2013202 201 202 2013-202 201320 20 2013-20 20132 2 2013-2 2013-

RESUMEN Objetivos: evaluar los factores de riesgo del exceso de volumen de líquido en pacientes en hemodiálisis. Métodos: estudio retrospectivo de casos y controles. Se incluyeron 392 pacientes (196 casos y 196 controles) de dos centros de hemodiálisis. Se evaluaron datos sociodemográficos y 23 factores de riesgo de exceso de volumen de líquido mediante un formulario de recolección de datos. Los datos se analizaron mediante un modelo de regresión logística multivariado. Resultados: factores de riesgo conocimiento insuficiente (OR=2,06), ingesta excesiva de líquidos (OR=2,33), retirada inadecuada de líquidos durante la hemodiálisis (OR=2,62) e ingesta excesiva de sodio (OR=1,91) pueden aumentar aproximadamente dos veces la posibilidad de que se produzca un exceso de volumen de líquido en pacientes en hemodiálisis. La educación (OR=0,95) y la edad (OR=0,97) son factores protectores del volumen excesivo de líquido. Conclusiones: conocer estos factores de riesgo puede ayudar a las enfermeras a realizar una inferencia diagnóstica precisa y rápida del riesgo de volumen excesivo de líquidos. Objetivos Métodos controles 39 (19 19 2 multivariado Resultados OR=2,06, OR206 OR OR=2,06 , 06 (OR=2,06) OR=2,33, OR233 OR=2,33 33 (OR=2,33) OR=2,62 OR262 62 (OR=2,62 OR=1,91 OR191 1 91 (OR=1,91 OR=0,95 OR095 0 95 (OR=0,95 OR=0,97 OR097 97 (OR=0,97 Conclusiones 3 (1 OR20 OR=2,0 (OR=2,06 OR23 OR=2,3 (OR=2,33 OR=2,6 OR26 6 (OR=2,6 OR=1,9 OR19 9 (OR=1,9 OR=0,9 OR09 (OR=0,9 ( OR2 OR=2, (OR=2,0 (OR=2,3 (OR=2, OR=1, OR1 (OR=1, OR=0, OR0 (OR=0, OR=2 (OR=2 OR=1 (OR=1 OR=0 (OR=0 OR= (OR= (OR

ABSTRACT Objectives: to assess risk factors for excess fluid volume in hemodialysis patients. Methods: a retrospective case-control study was conducted. A total of 392 patients (196 cases and 196 controls) from two hemodialysis centers were included. Sociodemographic data and 23 risk factors for excess fluid volume were assessed using a data collection form. Data were analyzed using a multivariate logistic regression model. Results: the insufficient knowledge (OR=2.06), excessive fluid intake (OR=2.33), inadequate fluid removal during hemodialysis (OR=2.62) and excessive sodium intake (OR=1.91) risk factors may increase the chance of occurrence of excess fluid volume in hemodialysis patients by approximately two times. Education level (OR=0.95) and age (OR=0.97) are protective factors for excessive fluid volume. Conclusions: knowing these risk factors may help nurses with accurate and rapid diagnostic inference of the risk of excessive fluid volume. Objectives Methods casecontrol case control conducted 39 (19 19 controls included 2 form model Results OR=2.06, OR206 OR OR=2.06 , 06 (OR=2.06) OR=2.33, OR233 OR=2.33 33 (OR=2.33) OR=2.62 OR262 62 (OR=2.62 OR=1.91 OR191 1 91 (OR=1.91 times OR=0.95 OR095 0 95 (OR=0.95 OR=0.97 OR097 97 (OR=0.97 Conclusions 3 (1 OR20 OR=2.0 (OR=2.06 OR23 OR=2.3 (OR=2.33 OR=2.6 OR26 6 (OR=2.6 OR=1.9 OR19 9 (OR=1.9 OR=0.9 OR09 (OR=0.9 ( OR2 OR=2. (OR=2.0 (OR=2.3 (OR=2. OR=1. OR1 (OR=1. OR=0. OR0 (OR=0. OR=2 (OR=2 OR=1 (OR=1 OR=0 (OR=0 OR= (OR= (OR

RESUMO Objetivos: avaliar os fatores de risco para o excesso de volume de líquidos em pacientes em hemodiálise. Métodos: estudo retrospectivo caso-controle. Foram incluídos 392 pacientes (196 casos e 196 controles) de dois centros de hemodiálise. Dados sociodemográficos e 23 fatores de risco para excesso de volume de líquidos foram avaliados por meio de formulário de coleta de dados. Os dados foram analisados por meio de modelo de regressão logística multivariada. Resultados: os fatores de risco conhecimento insuficiente (OR=2,06), ingestão excessiva de líquidos (OR=2,33), retirada inadequada de líquidos durante hemodiálise (OR=2,62) e ingestão excessiva de sódio (OR=1,91) podem aumentar a chance de ocorrência de excesso de líquidos volume em pacientes em hemodiálise em aproximadamente duas vezes. Escolaridade (OR=0,95) e idade (OR=0,97) são fatores de proteção para volume excessivo de líquidos. Conclusões: conhecer esses fatores de risco pode auxiliar enfermeiros na inferência diagnóstica precisa e rápida do risco de volume excessivo de líquidos. Objetivos Métodos casocontrole. casocontrole caso controle. controle caso-controle 39 (19 19 controles 2 multivariada Resultados OR=2,06, OR206 OR OR=2,06 , 06 (OR=2,06) OR=2,33, OR233 OR=2,33 33 (OR=2,33) OR=2,62 OR262 62 (OR=2,62 OR=1,91 OR191 1 91 (OR=1,91 vezes OR=0,95 OR095 0 95 (OR=0,95 OR=0,97 OR097 97 (OR=0,97 Conclusões 3 (1 OR20 OR=2,0 (OR=2,06 OR23 OR=2,3 (OR=2,33 OR=2,6 OR26 6 (OR=2,6 OR=1,9 OR19 9 (OR=1,9 OR=0,9 OR09 (OR=0,9 ( OR2 OR=2, (OR=2,0 (OR=2,3 (OR=2, OR=1, OR1 (OR=1, OR=0, OR0 (OR=0, OR=2 (OR=2 OR=1 (OR=1 OR=0 (OR=0 OR= (OR= (OR

ABSTRACT Objective: To assess the performance of a portable autorefractor as refractor and screening tool for refractive errors in schoolchildren. Methods: Cross-sectional observational study. Refractometric measurements of children between 5 and 10 years old were obtained through four methods: 2WIN under non-cycloplegic conditions, and 2WIN, conventional autorefractor, and retinoscopy, under cycloplegic conditions. Correlations and agreement between the methods and accuracy of the portable autorefractor to define whether to prescribe glasses were assessed. Results: The mean age ± standard deviation was 6.87 ± 1.42 years. The portable autorefractor without cycloplegia showed a high correlation with retinoscopy (0.77) but tended to underestimate hyperopia and overestimate high astigmatism. Regarding screening for prescription of glasses in comparison with the reference method “retinoscopy,” the sensitivity of the portable autorefractor without cycloplegia was calculated to be 100,00% and the specificity, 34.3%. Conclusion: The portable autorefractor should be used as a screening tool and, when prescribing glasses, the tendency of underestimating hyperopia and overestimating high astigmatism should be kept in mind. Objective schoolchildren Methods Crosssectional Cross sectional study 1 WIN noncycloplegic non conditions assessed Results 687 6 87 6.8 142 42 1.4 0.77 077 0 77 (0.77 “retinoscopy, 10000 100 00 100,00 specificity 343 34 3 34.3% Conclusion mind 68 8 6. 14 4 1. 0.7 07 7 (0.7 “retinoscopy 1000 100,0 34.3 0. (0. 100, 34. (0 (

RESUMO Objetivo: Avaliar o desempenho de um autorrefrator portátil como refrator e ferramenta de triagem para erros de refração em crianças em idade escolar. Métodos: Estudo observacional transversal. As medidas refratométricas de crianças de 5 a 10 anos foram obtidas por meio de quatro métodos: 2WIN em condições não cicloplégicas e 2WIN, autorrefrator convencional e retinoscopia, em condições cicloplégicas. Foram avaliadas as correlações e a concordância entre os métodos e a acurácia do autorrefrator portátil para definir a prescrição de óculos. Resultados: A média de idade ± desvio-padrão foi de 6,87 ± 1,42 anos. O autorrefrator portátil sem cicloplegia apresentou alta correlação com a retinoscopia (0,77), mas tendeu a subestimar a hipermetropia e a superestimar o alto astigmatismo. Em relação à triagem para prescrição de óculos em comparação com o método de referência retinoscópio, a sensibilidade do autorrefrator portátil sem cicloplegia foi calculada em 100,00% e a especificidade, em 34,3%. Conclusão: O autorrefrator portátil deve ser usado como ferramenta de triagem e, ao se prescreverem óculos, deve-se ter em mente a tendência de subestimar a hipermetropia e superestimar o alto astigmatismo. Objetivo escolar Métodos transversal 1 WIN Resultados desviopadrão desvio padrão 687 6 87 6,8 142 42 1,4 0,77, 077 0,77 , 0 77 (0,77) astigmatismo retinoscópio 10000 100 00 100,00 especificidade 343 34 3 34,3% Conclusão devese 68 8 6, 14 4 1, 07 0,7 7 (0,77 1000 100,0 34,3 0, (0,7 100, 34, (0, (0 (

Abstract Resin composites containing surface pre-reacted glass (S-PRG) have been introduced to reduce demineralization and improve remineralization of the tooth structure. However, water diffusion within the material is necessary for its action, which can impair its overall physicomechanical properties over time, including color stability. This study aimed to evaluate the color stability and related degree of conversion (DC) of four resin composites. Discs (6 x 4 mm, n = 5/group) of microhybrid (MH), nanofilled (NF), nanohybrid (NH), and S-PRG-based nanohybrid (S-PRG-NH) composites with two opacities (A2/A2E and A2O/A2D) were prepared. Color (CIELab and CIEDE2000) was evaluated with a spectrophotometer after aging in grape juice (2 x 10 min/10mL/7days). The DC was analyzed by using Fourier transform infrared spectroscopy before and after light-curing. Data were statistically analyzed by using two-way analysis of variance and post-hoc least significant difference tests (p<0.05). In the color stability analysis, the interaction between filler type and opacity was significant (CIELab, p = 0.0015; CIEDE2000, p = 0.0026). NH presented the highest color stability, which did not differ from that of MH. The greatest color alteration was observed for S-PRG-NH. S-PRG fillers also influenced DC (p < 0.05). The nanohybrid resin composite presented favorable overall performance, which is likely related to its more stable organic content. Notwithstanding the benefits of using S-PRG-based nanohybrid resins, mostly in aesthetic procedures, professionals should consider the susceptibility of such resins to color alteration, probably due to the water-based bioactive mechanism of action. prereacted pre reacted SPRG S PRG (S-PRG structure However action time (DC 6 ( mm 5/group 5group group 5 MH, MH , (MH) NF, NF (NF) NH, (NH) SPRGbased based SPRGNH (S-PRG-NH A2/A2E A2A2E AAE A2 A2E A E A2O/A2D A2OA2D AOAD A2O A2D O D prepared CIELab CIEDE2000 CIEDE 2 1 min/10mL/7days. min10mL7days minmLdays min/10mL/7days . min 10mL 7days mL days min/10mL/7days) lightcuring. lightcuring light curing. curing light-curing twoway way posthoc post hoc p<0.05. p005 p<0.05 0 05 (p<0.05) CIELab, 0.0015 00015 0015 0.0026. 00026 0.0026 0026 0.0026) SPRGNH. NH. S-PRG-NH 0.05. 005 0.05 0.05) performance content procedures waterbased (MH (NF (NH AE OA AO AD CIEDE200 p00 p<0.0 (p<0.05 0.001 0001 001 0002 0.002 002 00 0.0 CIEDE20 p0 p<0. (p<0.0 0.00 000 0. CIEDE2 p<0 (p<0. p< (p<0 (p<

ABSTRACT Background: The riverine communities of the Amazon comprise different social groups that inhabit the rural areas on the banks of rivers and lakes. Residents usually travel by river to rural and urban areas and are then exposed to urbanized diseases such as those caused by arbovirus infection. In Brazil, emerging diseases such as dengue, Zika, chikungunya, and those caused by infection with Oropouche and Mayaro viruses necessitate epidemiological surveillance. This study was aimed at determining the frequency of positivity for immunoglobulin (Ig)G and IgM antibodies against Zika, chikungunya, and dengue viruses and performing molecular analyses to detect viral RNA for the Zika, chikungunya, dengue virus, Oropouche, and Mayaro viruses, in the same serum samples obtained from riverside populations. Methods: This cross-sectional study was conducted in a riverside population in the Humaitá municipality of the Brazilian Amazon. More than 80% of the local population participated in this study. Entomological samples were collected to identify local mosquito vectors. Results: Analysis of 205 human serological samples revealed IgG antibodies against the dengue virus in 85 individuals. No molecular positivity was observed in human samples. Entomological analyses revealed 3,187 Diptera species, with Mansonia being the most frequent genus. Aedes aegypti and Aedes albopictus were not detected in the two collections. Conclusions: IgG antibodies against the dengue virus were highly prevalent, suggesting previous exposure. The absence of the arbovirus vectors Aedes aegypti and Aedes albopictus in the samples supports the hypothesis that the infections recorded likely occurred outside the riverside communities investigated. Background lakes Brazil Zika chikungunya surveillance Ig G populations Methods crosssectional cross sectional 80 Results 20 8 individuals 3187 3 187 3,18 species genus collections Conclusions prevalent exposure investigated 2 318 18 3,1 31 1 3,

RESUMEN Objetivo: Identificar los factores asociados a la omisión del cuidado de enfermería y al clima de seguridad del paciente. Método: Estudio transversal desarrollado en hospital universitario del Centro-Oeste brasileño, entre septiembre y diciembre de 2022. El MISSCARE-Brasil y el Safety AttitudesQuestionnaire fueron aplicados a una muestra de conveniencia en 164 profesionales de enfermería. Resultados: El cuidado más omitido fue la ambulación tres veces por día o conforme prescrito (66,5%). El puntaje general del Safety AttitudesQuestionnaire fue 63,8 (DE: 12,6). El nivel de satisfacción (p<0,018) y la percepción de adecuación profesional (p<0,018) se asociaron con la omisión de cuidados de enfermería y con el clima de seguridad del paciente. Conclusión: El estudio mostró alta prevalencia de omisión del cuidado y percepción desfavorable del clima de seguridade, asociados principalmente con la adecuación profesional para el desempeño del trabajo. Objetivo paciente Método CentroOeste Centro Oeste brasileño 2022 MISSCAREBrasil MISSCARE Brasil 16 Resultados 66,5%. 665 66,5% . 66 5 (66,5%) 638 63 8 63, DE (DE 12,6. 126 12,6 12 6 12,6) p<0,018 p0018 p 0 018 (p<0,018 Conclusión seguridade trabajo 202 1 66,5 (66,5% 12, p<0,01 p001 01 (p<0,01 20 66, (66,5 p<0,0 p00 (p<0,0 2 (66, p<0, p0 (p<0, (66 p<0 (p<0 (6 p< (p< ( (p

ABSTRACT Objective: To identify the factors associated with the omission of nursing care and patient safety climate. Method: A cross-sectional study developed at a university hospital in the Brazilian Center-West, between September and December 2022. The MISSCARE-Brazil and the Safety Attitudes Questionnaire were applied to a convenience sample of 164 nursing professionals. Results: The most omitted care was walking three times a day or as prescribed (66.5%). The overall score of the Safety Attitudes Questionnaire was 63,8 (SD: 12,6). The level of satisfaction (p<0.018) and the perception of professional adequacy (p<0.018) were associated with the omission of nursing care and the patient safety climate. Conclusion: The study showed a high prevalence of omission of care and unfavorable perception of the patient safety climate, mainly associated with professional adequacy for work performance. Objective climate Method crosssectional cross sectional CenterWest, CenterWest Center West, West Center-West 2022 MISSCAREBrazil MISSCARE Brazil 16 professionals Results 66.5%. 665 66.5% . 66 5 (66.5%) 638 63 8 63, SD (SD 12,6. 126 12,6 12 6 12,6) p<0.018 p0018 p 0 018 (p<0.018 Conclusion performance 202 1 66.5 (66.5% 12, p<0.01 p001 01 (p<0.01 20 66. (66.5 p<0.0 p00 (p<0.0 2 (66. p<0. p0 (p<0. (66 p<0 (p<0 (6 p< (p< ( (p

RESUMO Objetivo: Identificar os fatores associados à omissão do cuidado de enfermagem e ao clima de segurança do paciente. Método: Estudo transversal desenvolvido em hospital universitário do Centro-Oeste brasileiro, entre setembro e dezembro de 2022. O MISSCARE-Brasil e o Safety Attitudes Questionnaire foram aplicados a uma amostra de conveniência de 164 profissionais de enfermagem. Resultados: O cuidado mais omitido foi a deambulação três vezes por dia ou conforme prescrito (66,5%). O escore geral do Safety Attitudes Questionnaire foi 63,8 (DP: 12,6). O nível de satisfação (p<0,018) e a percepção de adequação profissional (p<0,018) associaram-se com a omissão do cuidado de enfermagem e com o clima de segurança do paciente. Conclusão: O estudo mostrou alta prevalência de omissão do cuidado e percepção desfavorável do clima de segurança, associados principalmente com a adequação profissional para desempenho do trabalho. Objetivo paciente Método CentroOeste Centro Oeste brasileiro 2022 MISSCAREBrasil MISSCARE Brasil 16 Resultados 66,5%. 665 66,5% . 66 5 (66,5%) 638 63 8 63, DP (DP 12,6. 126 12,6 12 6 12,6) p<0,018 p0018 p 0 018 (p<0,018 associaramse associaram se Conclusão trabalho 202 1 66,5 (66,5% 12, p<0,01 p001 01 (p<0,01 20 66, (66,5 p<0,0 p00 (p<0,0 2 (66, p<0, p0 (p<0, (66 p<0 (p<0 (6 p< (p< ( (p

Abstract Introduction: Primary health care (PHC) represents the first step of a network of health care processes that have the Family Health Strategy as their foundation for reorganization, expansion and consolidation. Objective: To investigate the effectiveness of the matrix support provided by the physical therapist to the community health agents (CHAs) regarding the level of knowledge about health conditions responsive to the performance of physiotherapy in PHC. Methods: We conducted a quasi-experimental study with two groups of CHAs, divided into control (n = 6) and intervention (n = 7), totaling 13 professionals belonging to a small municipality. Matrix support took place through educational workshops, addressing the axes of maternal and child health, adult health, health of older people and musculoskeletal disorders. For the initial assessment, a semi-open questionnaire was administered with sociodemographic data and work-related questions, a structured questionnaire containing questions related to the performance of physiotherapy in PHC that presents situations from the CHA's work routine, and a semi-open survey investigating patients to be referred to physiotherapy. For the final assessment, the same instruments were reapplied, except for the sociodemographic questionnaire. Results: After the intervention, in the comparison between groups, there was a difference in the risk perception index in the axis of musculoskeletal disorders (p = 0.032) and in the identification of cases of childhood changes (p = 0.012). In the intragroup comparison, the intervention group showed a difference in risk perception in the health of the older persons and in most of the items of the referral survey (p < 0.05 for all). Conclusion: Matrix support can contribute to the shared construction of knowledge, as well as to the activation of physiotherapy in PHC by CHAs. Introduction (PHC reorganization consolidation Objective CHAs (CHAs Methods quasiexperimental quasi experimental n 6 7, 7 , 7) 1 municipality workshops assessment semiopen semi open workrelated CHA s routine reapplied Results p 0.032 0032 0 032 0.012. 0012 0.012 . 012 0.012) 005 05 0.0 all. all all) Conclusion 0.03 003 03 001 0.01 01 00 0.

Resumo Introdução: A Atenção Primária à Saúde (APS) representa o primeiro elemento de uma rede de processos de atenção à saúde que tem na Estratégia Saúde da Família o alicerce para a sua reorganização, expansão e consolidação. Objetivo: Investigar a efetividade do apoio matricial (AM) realizado pelos fisioterapeutas para os agentes comunitários de saúde (ACS) em relação ao nível de conhecimento sobre condições de saúde sensíveis à atuação da fisioterapia na APS. Métodos: Trata-se de um estudo quase-experimental realizado com dois grupos de ACS, divididos em controle (n = 6) e intervenção (n = 7), totalizando 13 profissionais pertencentes a um município de pequeno porte. O AM aconteceu por meio de oficinas educativas, abordando os temas maternoinfantil, adulto, idoso e desordens musculoesqueléticas. Para a avaliação inicial foram aplicados um questionário semiaberto com dados sociodemográficos e questões relacionadas ao trabalho, um questionário estruturado contendo questões relacionadas à atuação da fisioterapia na APS, que apresentava situações da rotina de trabalho do ACS, e um inquérito semiaberto de investigação de pacientes a serem encaminhados para a fisioterapia. Para a avaliação final, os mesmos instrumentos foram reaplicados, exceto o questionário sociodemográfico. Resultados: Após o AM, na comparação entre os grupos, houve diferença estatística no índice de percepção de risco no eixo das desordens musculoesqueléticas (p = 0,032) e na identificação de casos de alterações infantis (p = 0,012). Na comparação intragrupo, o grupo intervenção apresentou diferença estatística na percepção de risco na saúde do idoso e na maioria dos itens do inquérito de encaminhamentos (p < 0,05 para todos). Conclusão: O AM pode contribuir para a construção compartilhada de saberes, bem como para o acionamento da fisioterapia na APS pelos ACS. Introdução (APS reorganização consolidação Objetivo (AM ACS (ACS Métodos Tratase Trata se quaseexperimental quase experimental n 6 7, 7 , 7) 1 porte educativas maternoinfantil adulto final reaplicados sociodemográfico Resultados p 0,032 0032 0 032 0,012. 0012 0,012 . 012 0,012) intragrupo 005 05 0,0 todos. todos todos) Conclusão saberes 0,03 003 03 001 0,01 01 00 0,