Abstract In this study, videothermometry’s application in detecting mammary tumors in dogs is explored in-depth. The research hypothesizes that this technique can effectively identify cancerous tissues during surgery by analyzing thermal patterns. The methodology involved comparing thermal imaging results from dogs with palpable mammary nodules against a control group, focusing on capturing real-time thermal patterns. Results were significant, showing distinct thermal patterns in carcinomas. This indicates videothermometry’s capability in accurately identifying micro metastases and differentiating between neoplastic and non-neoplastic changes. The study concludes that videothermometry has considerable potential in enhancing surgical precision, especially in tumor resection and safety margin definition, but emphasizes the need for further research to thoroughly understand the thermal signatures of various mammary tumors in dogs. videothermometrys s indepth. indepth depth. depth in-depth group realtime real time significant carcinomas nonneoplastic non changes precision definition

RESUMO Fundamento: As evidências acerca das sequelas a longo prazo após internação por síndrome do desconforto respiratório agudo por COVID-19 ainda são escassas. Objetivo: Avaliar alterações nas funções pulmonar, cardíaca e renal e na qualidade de vida após internação por síndrome do desconforto respiratório agudo secundária à COVID-19. Métodos: Trata-se de estudo multicêntrico, caso-controle, incluindo 220 participantes. Os casos serão definidos como pacientes hospitalizados por síndrome do desconforto respiratório agudo devido à COVID-19. No Grupo Controle, serão selecionados indivíduos sem histórico de hospitalização nos últimos 12 meses ou sintomas a longo prazo de COVID-19. Todos os indivíduos serão submetidos à espirometria pulmonar com teste de difusão pelo monóxido de carbono, tomografia de tórax, ressonância magnética cardíaca e renal com gadolínio, ergoespirometria, creatinina sérica e urinária, proteínas totais e microalbuminúria urinária, além de questionários de qualidade de vida. Os casos serão avaliados 12 meses após a alta hospitalar e os controles, 90 dias após a inclusão no estudo. Para todas as análises estatísticas, será assumido como significativo o valor p < 0,05. Resultados: O desfecho primário do estudo foi definido com a capacidade de difusão pulmonar aferida para o monóxido de carbono a partir de 12 meses. Os demais parâmetros das funções pulmonar, cardíacas e renal e da qualidade de vida foram definidos como desfechos secundários. Conclusão: Este estudo visa determinar as sequelas a longo prazo nas funções pulmonar, cardíaca e renal e na qualidade de vida de pacientes internados por síndrome do desconforto respiratório agudo devido à COVID-19 na população brasileira. Fundamento COVID19 COVID 19 COVID-1 escassas Objetivo COVID19. 19. Métodos Tratase Trata se multicêntrico casocontrole, casocontrole caso controle, controle caso-controle 22 participantes Controle 1 tórax gadolínio ergoespirometria urinária controles 9 estatísticas 005 0 05 0,05 Resultados secundários Conclusão brasileira COVID1 COVID- 2 00 0,0 0,

ABSTRACT Rationale: Evidence about long-term sequelae after hospitalization for acute respiratory distress syndrome due to COVID-19 is still scarce. Purpose: To evaluate changes in pulmonary, cardiac, and renal function and in quality of life after hospitalization for acute respiratory distress syndrome secondary to COVID-19. Methods: This will be a multicenter case–control study of 220 participants. Eligible are patients who are hospitalized for acute respiratory distress syndrome due to COVID-19. In the control group, individuals with no history of hospitalization in the last 12 months or long-term symptoms of COVID-19 will be selected. All individuals will be subjected to pulmonary spirometry with a carbon monoxide diffusion test, chest tomography, cardiac and renal magnetic resonance imaging with gadolinium, ergospirometry, serum and urinary creatinine, total protein, and urinary microalbuminuria, in addition to quality-of-life questionnaires. Patients will be evaluated 12 months after hospital discharge, and controls will be evaluated within 90 days of inclusion in the study. For all the statistical analyses, p < 0.05 is the threshold for significance. Results: The primary outcome of the study will be the pulmonary diffusing capacity for carbon monoxide measured after 12 months. The other parameters of pulmonary, cardiac, and renal function and quality of life are secondary outcomes. Conclusion: This study aims to determine the long-term sequelae of pulmonary, cardiac, and renal function and the quality of life of patients hospitalized for acute respiratory distress syndrome due to COVID-19 in the Brazilian population. Rationale longterm long term COVID19 COVID 19 COVID-1 scarce Purpose COVID19. 19. Methods casecontrol case 22 participants group 1 selected test tomography gadolinium ergospirometry creatinine protein microalbuminuria qualityoflife questionnaires discharge 9 analyses 005 0 05 0.0 significance Results outcomes Conclusion population COVID1 COVID- 2 00 0.

RESUMEN INTRODUCCIÓN: El suicidio es un problema prioritario de salud pública. Su monitoreo resulta de interés para la planificación de políticas públicas. El objetivo fue describir la tendencia de la mortalidad por suicidio en el nordeste argentino (NEA) según edad y sexo durante el período 1990-2020. MÉTODOS: Se realizó un estudio descriptivo y de diseño ecológico con fuentes de datos oficiales. Se calcularon tasas de mortalidad ajustadas a la edad. Para el análisis de las tendencias se aplicó el método de regresión segmentaria de Poisson y como medida de resumen se utilizó el porcentaje de cambio anual (PCA) de la tasa de mortalidad. RESULTADOS: La tasa ajustada a la edad de la mortalidad por suicidio de ambos sexos en el NEA presentó una variación entre 1990 y 2020 de 5,48 a 8,03 por 100 000 habitantes, con una tendencia al aumento de 0,9% en promedio por año. Se evidenciaron diferencias según edad y sexo. Tanto la magnitud de las tasas como el PCA fueron mayores en las personas de sexo masculino. Se presentaron cambios en el perfil de la situación a lo largo del período y, en general, la mortalidad por suicidio tendió a aumentar en la población de hasta 44 años de edad, a mantenerse estable en la de 45 a 54 años y a descender en la de 55 años y más. DISCUSIÓN: Los resultados coinciden con cambios en el perfil de la mortalidad por suicidio ya descriptos. Se destaca la importancia de realizar análisis locales de situación.

ABSTRACT INTRODUCTION: Suicide is a priority public health problem. Its monitoring is of interest for public policy planning. The objective was to describe suicide mortality trend in the Argentine Northeast region by age and sex during the period 1990-2020. METHODS: A descriptive and ecological design study was carried out with official data sources. Age-adjusted mortality rates were calculated. A Poisson segmented regression method was applied for trend analysis, and the annual percentage change (APC) of the mortality rate was used as a summary measure. RESULTS: The age-adjusted rate of suicide mortality for both sexes in the region varied between 1990 and 2020 from 5.48 to 8.03 per 100,000 inhabitants, with an upward trend of 0.9% on average per year. Differences by age and sex were observed. Both the magnitude of the rates and the APC were higher in males. There were changes in the situation profile throughout the period and, in general, mortality from suicide tended to increase in people aged up to 44 years, to remain stable in those aged 45 to 54 years, and to decrease in those aged 55 years and over. DISCUSSION: The results are consistent with changes in the suicide mortality profile already described. The importance of local situation analyses is highlighted.

Abstract Objective To verify the influence of low birth weight and rapid postnatal weight gain and associated factors on blood pressure in adolescence in a population of low socioeconomic status, considering that injuries occur in the perinatal period can be predictors of future metabolic changes and are still poorly explored. Methods A cohort study was carried out with 208 adolescents, 78 born with low weight and 130 born with appropriate weight. The infants were followed up during the first six postnatal months and reassessed at 8 and 18 years of age. The independent variables were birthweight and postnatal weight gain. Rapid postnatal weight gain was defined when above 0.67 z score. The co-variables were sex, maternal height and family income at birth, nutritional status at eight years old, socioeconomic conditions, nutritional status, fat mass index, and physical activity level at 18 years. The outcome variable was blood pressure at 18 years old. The bivariate and multivariable logistic regression analysis were realized and p < 0,05 was considered significant. Results The proportion of adolescents with elevated blood pressure was 37.5%. The multivariable logistic regression analysis showed the variables independently associated with a higher chance of elevated blood pressure in adolescence were rapid postnatal weight gain (OR = 2.74; 95% CI 1.22-6.14; p= 0.014), male sex (OR = 4.15; 95% CI 1.66-10.38; p= 0.002) and being physically active (OR = 2.70; 95% CI 1.08-6.74; p= 0.034). Conclusions The rapid postnatal weight gain was a predictor for elevated blood pressure in adolescence, independently of other factors. explored 20 7 13 1 age 067 0 67 0.6 score covariables co old conditions index 005 05 0,0 significant 375 37 5 37.5% OR 2.74 274 2 74 95 1.226.14 122614 1.22 6.14 22 6 14 1.22-6.14 0.014, 0014 0.014 , 014 0.014) 4.15 415 4 15 1.6610.38 1661038 1.66 10.38 66 10 38 1.66-10.38 0.002 0002 002 2.70 270 70 1.086.74 108674 1.08 6.74 08 1.08-6.74 0.034. 0034 0.034 . 034 0.034) 06 0. 00 0, 3 37.5 2.7 27 9 226 1.226.1 12261 122 1.2 614 6.1 1.22-6.1 001 0.01 01 4.1 41 6610 1.6610.3 166103 166 1.6 1038 10.3 1.66-10.3 0.00 000 086 1.086.7 10867 108 1.0 674 6.7 1.08-6.7 003 0.03 03 37. 2. 1.226. 1226 12 1. 61 6. 1.22-6. 0.0 4. 661 1.6610. 16610 16 103 10. 1.66-10. 1.086. 1086 1.08-6. 1.226 1.22-6 1.6610 1661 1.66-10 1.086 1.08-6 1.22- 1.661 1.66-1 1.08- 1.66-

RESUMO Este relato descreve um caso de hemangioma racemoso da retina que se apresentou inicialmente como hemorragia vítrea. Os autores apresentam o caso de uma mulher de 47 anos com perda visual súbita e indolor 5 dias antes no olho esquerdo. Na primeira visita, a melhor acuidade visual corrigida foi de 20/20 no olho direito e movimentos das mãos no olho esquerdo. A ultrassonografia mostrou uma retina aderida e uma hemorragia vítrea maciça. Foi realizada vitrectomia pars plana, sendo detectada proliferação de grandes vasos salientes do disco óptico. A acuidade visual no dia 30 de pós-operatório foi de 20/25 no olho esquerdo. A angiografia de retina e a angiotomografia de coerência óptica de domínio espectral mostraram comunicações arteriovenosas anômalas sem capilares intermediários. O diagnóstico foi hemangioma racemoso, uma malformação arteriovenosa da retina do grupo 2 com base na classificação de Archer. 4 esquerdo visita 2020 20 20/2 maciça plana óptico 3 pósoperatório pós operatório 2025 25 intermediários Archer 202 20/

ABSTRACT This report describes a case of retinal racemose hemangioma that first presented as a vitreous hemorrhage. The authors present the case of a 47-year-old woman with a sudden 5-day painless visual loss in her left eye. At the first visit, the best-correct visual acuities were 20/20 in the right eye and hand motions in the left eyes. Ultrasonography showed an attached retina and a massive vitreous hemorrhage. Pars plana vitrectomy was performed and a dilatation of large vessels was detected bulging from the optic disc. The best-correct visual acuities on day 30 postoperatively was 20/25 in the left eye. Fundus angiography and spectral-domain optical coherence tomography angiography showed anomalous arteriovenous communications with no intervening capillaries. The diagnosis was racemose hemangioma, an arteriovenous malformation of group 2 retina based on the Archer classification. hemorrhage 47yearold yearold 47 year old 5day 5 visit bestcorrect best correct 2020 20 20/2 eyes disc 3 2025 25 spectraldomain spectral domain capillaries classification 4 202 20/

Resumen: Introducción: el COVID-19 suscitó una preocupación particular para las personas con enfermedades reumáticas autoinmunes, debido a la conocida mayor susceptibilidad a las infecciones de este grupo de pacientes. Material y Métodos: es un estudio observacional descriptivo, retrospectivo, basado en registro de historias clínicas de pacientes ingresados en las salas respiratorias del Departamento de Cuidados Intensivos Adultos del Hospital de Clínicas (San Lorenzo, Paraguay) desde agosto de 2020 a marzo de 2022. Resultados: ingresaron 311 pacientes con COVID-19 a terapia intensiva. Ocho pacientes con diagnóstico de enfermedades reumatológicas (2,5 %). La mayoría con Lupus Eritematoso Sistémico (37,5%), todos tratados con corticoides previamente, un paciente con Artritis Reumatoidea en tratamiento con Metotrexate. La mediana de la edad fue de 43 años, la mayoría de sexo femenino (62,5%). Los pacientes ingresaron al hospital al octavo día del inicio del COVID-19. Todos los pacientes con comorbilidades: hipertensión arterial, diabetes mellitus y obesidad (37,5% cada una). Los síntomas predominantes fueron fiebre (62,5%) y disnea (50%). El APACHE II al ingreso tuvo una mediana de 15,5 y SOFA de Todos recibieron corticoides y 50 % remdesivir. Requirieron ARM y vasopresores en el 62,5% de los casos. Se observó sepsis de origen bacteriano en un 87,5 % de los pacientes. El desenlace fatal con Falla multiorgánica se observó en el 50% de los casos. Conclusiones: Se observó un bajo porcentaje de ingreso a terapia intensiva de pacientes reumatológicos con COVID-19, probablemente por adhesión estricta a las medidas higiénicas y de confinamiento que adoptaron estos pacientes desde el inicio de la pandemia. Los pacientes fueron en su mayoría de sexo femenino, con Score de gravedad de alta puntuación al ingreso. Se constató un alto porcentaje de requerimiento de asistencia respiratoria mecánica y vasopresores. La mortalidad fue elevada relacionada con el estado grave al ingreso de estos pacientes.

Abstract: Introduction: COVID-19 arouse particular concern for people with autoimmune rheumatic diseases, due to the known higher susceptibility to infections in this group of patients. Materials and methods: Descriptive observational and retrospective study, based on clinical records of patients admitted in respiratory unit at the Department Intensive Care Adult at Hospital de Clinicas (San Lorenzo, Paraguay) from August 2020 to march 2022. Results: 311 patients were admitted with COVID-19 to the intensive care unit. Eight of these patients with a rheumatic disease diagnose (2.5%). The majority with Systemic Erythema- tous Lupus (38.5%), all of them previously treated with corticoids, one patient with Rheu- matoid Arthritis also receiving Methrotrexate. The average age was 43 years, most of these patients were female (62.5%). These patients were admitted to the hospital on their eighth day of COVID-19 illness. All of them with comorbidity: hypertension, diabetes mellitus and obesity (37.5% each). The predominant symptoms were fever (62%) and dyspnea (50%). APACHE II scores at admission were on average 15.5 and the SOFA scores on average were 5. All of these patients recieved corticosteroids for COVID-19 and 50% of them recieved Remdesivir. Respiratory failure requiring mechanical ventilation and shock requiring vasopressors were seen in an equal amount of patients (62.5%). Infections were a frequent complication in these patients as sepsis was diagnosed in 87.5%. The 50% of the patients died as a result of multi-organ failure. Conclusions: Low percentage of admission to our intensive care unit for rheumatological patients with COVID-19, probably due to strict adherence to hygiene and confinement measures, and regular medical control. Female predominance. Severe patients with a high severity score at admission. High percentage of requiring mechanical respiratory assistance and vasopressors. High mortality related to the serious condition at admission of these patients.

Resumo Fundamento Alguns pacientes com COVID-19 apresentam injúria miocárdica. Objetivo Detectar a injúria miocárdica em pacientes criticamente doentes, e comparar o envolvimento cardíaco entre crianças com síndrome respiratória aguda grave (SARS) e crianças com síndrome inflamatória multissistêmica (MIS-C). Métodos Todas as crianças acometidas da COVID-19 admitidas em uma unidade de terapia intensiva de referência foram cadastradas de forma prospectiva e fizeram uma ecografia transtorácica bidimensional (ETT-2D) e um teste de troponina I cardíaca (cTnI) nas primeiras 72 horas. Para a análise estatística, um p <0,05 bilateral foi considerado significativo. Resultados 33 pacientes foram incluídos, dos quais 51,5% apresentaram cTnI elevada e/ou ETT-2D anormal e 36,4% precisaram de suporte cardiovascular, que foi mais frequente em pacientes com cTnI elevada e anormalidades em ETT-2D do que em pacientes com exames normais (83,3% e 33,3%, respectivamente; p 0,006, 95% IC = 0,15-0,73). Os achados de ETT-2D mais comuns foram efusão pericárdica (15,2%) e regurgitação tricúspide/mitral (15,2%). Sinais de envolvimento cardíaco foram mais comuns na MIS-C que na SARS. Pacientes com MIS-C também apresentaram um índice mais alto de necessidade de suporte cardiovascular (66,7% X 25%, p 0,03, 95% IC = -0,7 a -0,04) e um índice mais frequente de cTnI elevada (77,8% X 20,8%; p 0,002, 95% IC = 0,19 a 0,79). Os valores preditivos negativos de cTnI para detecção de anormalidades de ETT-2D foram 100% para pacientes com MIS-C, e 73,7% para pacientes com SARS. Conclusão Sinais de injúria cardíaca foram comuns, especialmente em pacientes com MIS-C. As anormalidades na ETT-2D foram sutis. A realização de um teste de cTnI na admissão pode ajudar os prestadores de assistência de saúde a discriminar os pacientes com uma necessidade mais urgente de uma ETT-2D.

Abstract Background Some patients with COVID-19 present myocardial injury. Objective To detect myocardial injury in critically ill paediatric patients, and to compare cardiac involvement between children with severe acute respiratory syndrome (SARS) and children with multisystemic inflammatory syndrome (MIS-C). Methods All COVID-19 children admitted to a referral intensive care unit were prospectively enrolled and had a two-dimensional echocardiogram (2D-TTE) and a cardiac troponin I (cTnI) assay within the first 72 hours. For statistical analysis, two-sided p < 0.05 was considered significant. Results Thirty-three patients were included, of which 51.5% presented elevated cTnI and/or abnormal 2D-TTE and 36.4% needed cardiovascular support, which was more frequent in patients with both raised cTnI and 2D-TTE abnormalities than in patients with normal exams (83.3% and 33.3%, respectively; p 0.006, 95% CI = 0.15-0.73). The most common 2D-TTE findings were pericardial effusion (15.2%) and mitral/tricuspid regurgitation (15.2%). Signs of cardiac involvement were more common in MIS-C than in SARS. MIS-C patients also presented a higher rate of the need for cardiovascular support (66.7% vs 25%, p 0.03, 95% CI = -0.7 to -0.04) and a more frequent rate of raised cTnI (77.8% vs 20.8%; p 0.002, 95% CI = 0.19 to 0.79). The negative predictive values of cTnI for the detection of 2D-TTE abnormalities were 100% for MIS-C patients and 73.7% for SARS patients. Conclusion signs of cardiac injury were common, mainly in MIS-C patients. 2D-TTE abnormalities were subtle. To perform a cTnI assay upon admission might help providers to discriminate those patients with a more urgent need for a 2D-TTE.

Abstract This paper presents measurements at a mock-up medium voltage network to verify the feasibility of Broadband Power Line Communication (BPLC). We use the data extracted within the frequency range 2 − 30 MHz to characterize a MIMO PLC network using different phase combinations, defining the best and worst use case scenarios. The empirical data shows that not only phases directly connected for input-output can be used, but also that we can exploit the coupling between phases to transmit and receive data, therefore creating a dynamic PLC network which will depend on the characteristics of the power grid. By making use of transmission line theory, we also demonstrate how we can mitigate the reflections by measuring the input impedance of the network to allow better use of the bandwidth available for BPLC operation.

RESUMO Objetivo: Conhecer as vulnerabilidades vivenciadas por adolescentes e adultas jovens infectadas pelo Papilomavírus Humano atendidas em um centro de referência em Feira de Santana - Bahia. Método: Estudo qualitativo, realizado entrevista semiestruturada com 20 adolescentes e adultas jovens, no período de novembro de 2020 a fevereiro de 2021. Para análise dos dados, utilizaram-se a Análise de Conteúdo proposta por Bardin e o software Iramuteq. Resultados: A descoberta da infecção realça a incompreensão sobre o adoecimento, o medo, o desespero e a culpa, dimensões individuais e coletivas que apontam para o baixo conhecimento sobre o Papilomavírus Humano. Considerações finais: Faz-se necessário a implementação de políticas públicas para minimizar os riscos, pelo conhecimento e enfrentamento às infecções sexualmente transmissíveis, bem como estratégias de promoção da saúde e decisões compartilhadas para o processo de mudança de comportamento em adolescentes e adultas jovens.

ABSTRACT Objective: To know the vulnerabilities experienced by adolescents and young adults infected by the Human Papillomavirus attended at a reference center in Feira de Santana - Bahia. Method: Qualitative study, carried out with a semi-structured interview with 20 adolescents and young adults, from November 2020 to February 2021. For data analysis, the Content Analysis proposed by Bardin and the software Iramuteq were used. Results: The discovery of the infection highlights the misunderstanding about illness, fear, despair and guilt, individual and collective dimensions that point to little knowledge about the Human Papillomavirus. Final considerations: It is necessary to implement public policies to minimize risks, through knowledge and confrontation of sexually transmitted infections, as well as health promotion strategies and shared decisions for the process of behavior change in adolescents and young adults.

RESUMEN Objetivo: Conocer las vulnerabilidades vividas por adolescentes y adultos jóvenes infectados por el Virus del Papiloma Humano atendidos en un centro de referencia en Feira de Santana - Bahia. Método: Estudio cualitativo, realizado con entrevista semiestructurada a 20 adolescentes y adultos jóvenes, de noviembre de 2020 a febrero de 2021. Para el análisis de datos se utilizó el Análisis de Contenido propuesto por Bardin y el software Iramuteq. Resultados: El descubrimiento de la infección destaca la incomprensión sobre la enfermedad, el miedo, la desesperación y la culpa, dimensiones individuales y colectivas que apuntan al bajo conocimiento sobre el Virus del Papiloma Humano. Consideraciones finales: Es necesario implementar políticas públicas para la minimización de riesgos, a través del conocimiento y enfrentamiento de las infecciones de transmisión sexual, así como estrategias de promoción de la salud y decisiones compartidas para el proceso de cambio de comportamiento en adolescentes y adultos jóvenes.

Abstract Telomere has a central role in chromosomal stability events. Chromosome ends organized in telomere-loop prevent activation of DNA damage response (DDR) mechanisms, thus keeping the chromosome structure organized. On the other hand, free chromosome ends, dysfunctional telomeres, and interstitial telomeric sequences (ITS) can trigger chromosome rearrangements. Here, the telomere organization, function, and maintenance mechanisms, in addition to ITS types and their involvement in chromosome changes, were revisited. Despite a general (TTAGGG)n sequence being present in vertebrate telomeres, insects show more diversification of their telomere motif. The relation between ITS and chromosome rearrangements was observed in insects and vertebrates, demonstrating different types of genome organization and distribution. Some ITS cannot be considered relicts of chromosome rearrangements because probable they were inserted during a double-strand break repair mechanism. On the other hand, the involvement of telomere sequences participating or triggering chromosome rearrangements or organizing satellite DNA components in several species groups is evident. The genomic assembling advances and applying other methodologies over ITS, and their flanking regions, can help to understand the telomere participation in the chromosomal evolution in species groups with highly diversified karyotypes.

Resumo: Introdução: Os serviços destinados à atenção psicossocial são essenciais para a garantia de direitos da população assistida e a aquisição de um processo longo, e ainda atual, denominado de Reforma Psiquiátrica, com um desenho de política pública de estratégias e programas para a efetivação de um cuidado voltado para o indivíduo e seu contexto social. Entre as estratégias e os programas, destaca-se o acolhimento como interlocutor dos processos que envolvem o usuário da rede de atenção psicossocial e os serviços prestados pelas unidades de saúde, com ênfase no Centro de Atenção Psicossocial e em particular o álcool e drogas (CAPSad). O presente relato de experiência visa apresentar as nuances do acolhimento presentes nos serviços e nas atividades prestados por um CAPSad de um município do interior da Bahia e a importância dessa vivência para a formação médica. Relato de experiência: As experiências foram apresentadas em quatro momentos: primeiros contatos e a experiência de aproximação com o CAPSad; simpósio sobre o cuidado destinado ao usuário de álcool e outras drogas; acompanhamento de consultas médicas em saúde mental; e realização de atividades em sala de espera e com grupos terapêuticos. Discussão: As experiências sobre o cuidado integral destinado à saúde mental possibilitaram ao estudante de Medicina vivenciar o acolhimento e as singularidades da atenção psicossocial; conhecer as vulnerabilidades das pessoas que fazem uso de álcool e drogas ilícitas; perceber a importância da família no processo de cuidado; participar de consultas médicas baseadas no Método Clínico Centrado na Pessoa; e compreender imprescindibilidade da atenção multiprofissional para a integralidade das ações em saúde. Conclusão: O cuidado integral destinado à saúde mental apresenta-se como um tema desafiador e necessário para a formação do futuro médico. A inserção do estudante na rede de atenção psicossocial favorece os processos voltados para o ensino-aprendizagem e fortalece a integração ensino, serviço e comunidade.

Abstract: Introduction: Services aimed at psychosocial care are essential for guaranteeing the rights of the assisted population, acquiring a long process, and still current, called Psychiatric Reform, with a public policy design of strategies and programs for the effectiveness of care aimed at the individual and their social context. Among these, embracement stands out as an interlocutor in the processes that involve the user of the Psychosocial Care Network and the services provided by the health units, with emphasis on the Psychosocial Care Center and in particular care related to alcohol and drug users (CAPSad). The present experience report aims to present the nuances of embracement present in the services and activities provided by a CAPSad in a municipality in the interior of Bahia and the importance of this experience for medical training. Experience report: the experiences were presented in four moments: first contacts and the experience of getting to know the CAPSad; Symposium on the care of users of alcohol and other drugs, monitoring medical consultations in mental health and carrying out activities in the waiting room and with therapeutic groups. Discussion: The experiences of comprehensive mental health care enabled the medical student to experience embracement and the singularities of psychosocial care; understand the vulnerabilities of people who use alcohol and illicit drugs; the importance of the family in the care process; participate in medical consultations based on the Person-Centered Clinical Method; as well as multiprofessional care for the integrality of health actions. Conclusion: Comprehensive mental health care constitutes a challenging and necessary topic for the training of the future physician. The inclusion of the student in the psychosocial care network favors the processes aimed at teaching-learning and strengthens the teaching-service-community integration.

Abstract Aim: This study aimed to verify the reproducibility of an endurance test for master swimmers. Methods: Seventeen male swimmers, aged from 30 to 50 years (35.06 ± 5.36), weight (78.71 ± 13.06 kg), height (174.35 ± 0.07 cm), participated in this study. The participants underwent the Progressive Swim Test (PSwT), which corresponds to swimming progressively to exhaustion in a 25-meter pool, guided by the recording of sound signals indicating the swimming rhythm. We verified the following variables: heart rate before the test (BHR) and right after the end of the test (AHR), followed by the rate of perceived exertion (RPE) and a total of laps performed (SN - swimming number). For comparison between the three days of tests, the one-way repeated measures ANOVA with Tukey's Post-Hoc was performed. Relative reproducibility was performed by the r test and the intraclass correlation coefficient (ICC). Absolute reproducibility was determined using the coefficient of variation (CV) and the confidence interval (CI). Results: The results showed high reproducibility in (PSwT) in master swimmers in the analyzed variables of intergroup and intragroup with relative reproducibility of r > 0.60 and ICC > 0.70 and absolute reproducibility with CI 95% (lower −1.10 and upper 0.99) and CV < 10%. Most of the cases were within the limits of agreement of the Bland-Altman tests, all variables were considered a level of significance with (p <0.05). Conclusion: The Progressive Swim Test (PSwT) is a reproducible instrument in the assessment of endurance in master swimmers.

RESUMO O sono é essencial para o adequado funcionamento de todos os indivíduos. Os distúrbios respiratórios do sono ocorrem em todas as faixas etárias, constituindo motivo frequente de consulta médica. O objetivo deste consenso foi atualizar os conhecimentos sobre os principais distúrbios respiratórios do sono tanto na população adulta quanto na pediátrica, com ênfase na apneia obstrutiva do sono. A apneia obstrutiva do sono é uma doença extremamente prevalente, porém frequentemente subdiagnosticada. Associa-se frequentemente a uma série de comorbidades, notadamente cardiovasculares, metabólicas e neurocognitivas, que impactam significativamente na qualidade de vida e na mortalidade. Por conta disso, o Departamento de Distúrbios Respiratórios do Sono da Sociedade Brasileira de Pneumologia e Tisiologia reuniu 14 especialistas com reconhecida e comprovada experiência em distúrbios respiratórios do sono para a elaboração deste documento.

ABSTRACT Sleep is essential for the proper functioning of all individuals. Sleep-disordered breathing can occur at any age and is a common reason for medical visits. The objective of this consensus is to update knowledge about the main causes of sleep-disordered breathing in adult and pediatric populations, with an emphasis on obstructive sleep apnea. Obstructive sleep apnea is an extremely prevalent but often underdiagnosed disease. It is often accompanied by comorbidities, notably cardiovascular, metabolic, and neurocognitive disorders, which have a significant impact on quality of life and mortality rates. Therefore, to create this consensus, the Sleep-Disordered Breathing Department of the Brazilian Thoracic Association brought together 14 experts with recognized, proven experience in sleep-disordered breathing.

Abstract In recent years, nanocarriers have been studied as promising pharmaceutical tools for controlled drug-delivery, treatment-efficacy follow-up and disease imaging. Among them, X-shaped amphiphilic polymeric micelles (Tetronic®, poloxamines) display great potential due to their biocompatibility and non-toxic effects, among others. In the present work, polymeric micelles based on the T1307 copolymer were initially decorated with a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-fluorophore in order to determinate its in vivo biodistribution on 4T1 tumor-bearing mice. However, unfavorable results with this probe led to two different strategies. On the one hand, the BODIPY-micelle-loaded, L-T1307-BODIPY, and on the other hand, the 99mTc-micelle-radiolabeled, L-T1307- 99m Tc, were analyzed separately in vivo. The results indicated that T1307 accumulates mainly in the stomach, the kidneys, the lungs and the tumor, reaching the maximum organ-accumulation 2 hours after intravenous injection. Additionally, and according to the results obtained for L-T1307- 99m Tc, the capture of the polymeric micelles in organs could be observed up to 24 hours after injection. The results obtained in this work were promising towards the development of new radiotracer agents for breast cancer based on X-shaped polymeric micelles.

Abstract The complex relations between Christianity and science seem to present a critical point in evolutionary theory, especially for the challenges it poses to the doctrine of original sin. I investigate the precise senses in which evolution threatens (or not) the Augustinian/Reformed formulation of original sin, analyzing each of the six tenets of the doctrine vis a vis nine evolutionary claims, as well as the supposed clash between the narratives of evolution and Christianity. I show that the threat is less impressive than it is usually assumed, and I highlight where the conflict really lies. I defend that it is possible to remain faithful to the core of the doctrine of original sin and to accept the reliability of evolution as a scientific theory. I present three scenarios for “Adam and Eve” and interpret them using two different models. I favor the understanding of Adam and Eve as the whole initial human bottleneck viewed through the lens of a multilevel model.