RESUMO: Objetivou-se avaliar a eficácia do sulfato de magnésio e cetamina em reduzir o requerimento de propofol, remifentanil e o resgate analgésico pós-operatório de gatas submetidas à ovariohisterectomia eletiva. Trinta gatas foram pré-medicadas com acepromazina (0,05 mg/kg) e morfina (0,3 mg/kg), intramuscular, e induzidas a inconsciência com propofol para intubação orotraqueal. As infusões contínuas (IC) de propofol e remifentanil foram iniciadas e os animais foram aleatoriamente alocados em três grupos: grupo sulfato de magnésio (MG) que recebeu bolus (50 mg/kg) e IC (80 mg/kg) de sulfato de magnésio; grupo cetamina (KG) que recebeu bolus (0,5 mg/kg) e IC (1,8 mg/kg/h) de cetamina; grupo controle (CG) que recebeu bolus e IC de solução salina 0,9%. As funções cardiovasculares e respiratórias, o tempo de extubação e a pontuação de resgate pós-operatório foram registrados e descritos com nível de significância de 95% (P < 0.05). O tempo de infusão dos tratamentos foi de 21,5 ± 3,4 e 21,0 ± 2,4 minutos no KG e MG, respectivamente (P = 0.194). As taxas de infusões de remifentanil (P = 0.336) e propofol (P = 0.716) foram similares entre grupos. Na análise de dor pós-operatória as escalas não demonstraram diferenças entre grupos quanto a número de resgates, pontuação de resgate ou tempo para o primeiro resgate. Em conclusão, os protocolos propostos foram seguros e efetivos. Contudo, o sulfato de magnésio e cetamina não demonstraram analgesia pós-operatória adicional ou efeitos adjuvantes anestésicos significativos. RESUMO Objetivouse Objetivou se pósoperatório pós operatório eletiva prémedicadas pré medicadas 0,05 005 0 05 (0,0 mg/kg mgkg mg kg 0,3 03 3 (0, mg/kg, , intramuscular orotraqueal (IC MG (MG 50 (5 80 (8 (KG 0,5 5 1,8 18 1 8 (1, mg/kg/h mgkgh h CG (CG 09 9 0,9% respiratórias 95 P 0.05. 0.05 . 0.05) 215 21 21, 34 4 3, 210 24 2 2, 0.194. 0194 0.194 194 0.194) 0.336 0336 336 0.716 0716 716 pósoperatória operatória resgates conclusão efetivos Contudo significativos 0,0 00 0, (0 ( 1, (1 0,9 0.0 019 0.19 19 0.33 033 33 0.71 071 71 0. 01 0.1 0.3 0.7 07 7

ABSTRACT: This study assessed the efficacy of magnesium sulfate and ketamine hydrochloride in reducing the demand for propofol, remifentanil, and postoperative rescue analgesia in cats undergoing elective ovariohysterectomy. Thirty cats were premedicated with acepromazine (0.05 mg/kg) and morphine (0.3 mg/kg) intramuscularly and induced to unconsciousness with propofol for orotracheal intubation. The continuous infusion (CI) of propofol and remifentanil were started and animals and were randomly allocated into three groups: the magnesium sulfate group (MG) received one bolus (50 mg/kg) and CI (80 mg/kg/h) of magnesium sulfate; the ketamine group (KG) received bolus (0.5 mg/kg) and CI (1.8 mg/kg/h) of ketamine hydrochloride; the control group (CG) received bolus and CI of 0.9% saline solution. Cardiovascular and respiratory functions, extubation time, and rescue postoperative scores were assessed and data were described with a significance level of 95% (P < 0.05). The infusion period of treatments was 21.5 ± 3.4 and 21.0 ± 2.4 minutes in the KG and MG, respectively (P = 0.194). The infusion rates of remifentanil (P = 0.336) and propofol (P = 0.716) were similar between groups. Analysis of the postoperative pain scales revealed no significant intergroup differences in rescue frequency, rescue score, and time to the first rescue analgesia. In conclusion, the proposed protocols were safe and effective, yet it is noteworthy that both magnesium sulfate and ketamine failed to demonstrate significant additional postoperative analgesic or adjuvant anesthetic effects. ABSTRACT ovariohysterectomy 0.05 005 0 05 (0.0 mg/kg mgkg mg kg 0.3 03 3 (0. intubation (CI groups MG (MG 50 (5 80 (8 mg/kg/h mgkgh h (KG 0.5 5 1.8 18 1 8 (1. CG (CG 09 9 0.9 solution functions 95 P 0.05. . 0.05) 215 21 21. 34 4 3. 210 24 2 2. 0.194. 0194 0.194 194 0.194) 0.336 0336 336 0.716 0716 716 frequency score conclusion effective effects 0.0 00 0. (0 ( 1. (1 019 0.19 19 0.33 033 33 0.71 071 71 01 0.1 0.7 07 7

RESUMEN La literatura teórica indica que el gasto en seguridad pública es importante para disuadir el comportamiento delictivo. Sin embargo, la mayoría de los estudios empíricos destinados a cuantificar la influencia del gasto en seguridad pública sobre la delincuencia no han podido establecer una relación estadísticamente significativa entre estas variables. En respuesta a esto, introdujimos un indicador novedoso que mide la asignación de los gastos de seguridad pública en cada región. Al probarlo para delitos de homicidio, robo y hurto de vehículos a través del estimador gmm-sys, encontramos evidencia estadística de que su ocurrencia influye en la conducta delictiva. Creemos que su inclusión aporta evidencia valiosa a la literatura económica, arrojando luz sobre el debate en torno a la eficiencia en la asignación de recursos del gasto en seguridad.

ABSTRACT Theoretical literature indicates that public security spending matters to deter criminal behavior. Nevertheless, most empirical studies aiming to quantify the influence of public security spending on crime have largely been unable to establish a statistically significant relationship between these variables. In response to this, we introduced a novel proxy that measures the rationing of public security expenditures in each region. When testing it for crimes of homicide, robbery, and theft of vehicles through the gmm-sys estimator, we found statistical evidence that its occurrence influences criminal behavior. We believe its inception contributes valuable evidence to the economic literature, shedding light on the debate surrounding the allocative efficiency of security spending resources.

ABSTRACT This case report presents the details of a 33-year-old female patient who was referred to a specialized retina service because of mild vision loss in her right eye). The patient’s visual acuity was 20/25 in right eye and 20/50 in the left eye (; amblyopic); the spherical equivalent was -12.75 diopters (right eye) and -14.75 diopters (left eye). Multimodal retinal imaging showed peripapillary schisis in both the inner and outer retinal layers, grade II posterior vitreous detachment, and a tessellated fundus. Using Humphrey perimetry and MP-3 microperimetry, the functional evaluation indicated macular sensitivity within normal limits and decreased sensitivity in the peripapillary region, especially in right eye. The pattern-re versal visual evoked potential was measured. The N75 and P100 latency and amplitude in right eye were within normal values for checks of 1º. However, the amplitude was low for checks of 15′. Highly myopic patients who have posterior staphyloma that involves the optic nerve are susceptible to posterior hyaloid traction, and the resulting peripapillary vitreous traction may compromise vision. 33yearold yearold 33 year old . s 2025 20 25 20/2 2050 50 20/5 ( amblyopic amblyopic) 12.75 1275 12 75 -12.7 14.75 1475 14 -14.7 layers detachment fundus MP3 MP 3 MP- microperimetry region patternre pattern re measured N N7 P P10 1º º However 15 15′ 202 2 20/ 205 5 12.7 127 1 7 -12. 14.7 147 -14. P1 12. -12 14. -14 -1 -

RESUMO Este relato de caso apresenta um paciente feminino de 33 anos encaminhado para um serviço especializado de retina devido à leve perda de visão em olho direito. A acuidade visual foi de 20/25 no olho direito e 20/50 no olho esquerdo, o equivalente esférico foi de -12,75 dioptrias e -14,75 dioptrias, respectivamente. Avaliações multimodais revelaram isquese peripapilar nas camadas internas e externas da retina, descolamento vítreo posterior grau II e fundo tesselado. Avaliação funcional com perimetria Humphrey e microperimetria MP-3 revelaram sensibilidade macular normais e diminuição da sensibilidade na região peripapilar, especialmente no olho direito. Potencial visual evocado de padrão reverso apresentou no olho direito latência e amplitude N75 e P100 dentro dos valores normais para verificação de 1º. Entretanto, a amplitude foi baixa para a de 15′. Pacientes alto míopes com esfiloma posterior envolvendo o nervo óptico são suscetíveis à tração da hialoide posterior. Portanto a tração vitreopapilar resultante pode causar comprometimento da visão. 3 2025 20 25 20/2 2050 50 20/5 esquerdo 12,75 1275 12 75 -12,7 14,75 1475 14 -14,7 respectivamente tesselado MP3 MP MP- N N7 P P10 1º º Entretanto 15 15′ 202 2 20/ 205 5 12,7 127 1 7 -12, 14,7 147 -14, P1 12, -12 14, -14 -1 -

Abstract This study investigated microshear bond strength (µSBS) of two (2) dual-cured resin-luting agents (RelyX™ Ultimate and RelyX™ U200) when photoactivated through varying thicknesses of lithium disilicate, with or without thermal cycling. Discs of IPS e.max Press of 0.5, 1.5, and 2 mm in thickness were obtained. Elastomer molds (3.0 mm in thickness) with four cylinder-shaped orifices 1.0 mm in diameter, were placed onto the ceramic surfaces and filled with resin-luting agents. A Mylar strip, glass plate, and load of 250 grams were placed over the filled mold. The load was removed and the resin-luting agents were photoactivated through the ceramics using a single-peak LED (Radii Plus.) All samples were stored in distilled water at 37oC for 24 h. Half of the samples were subjected to thermal cycling (3,000 cycles; 5ºC and 55ºC). All samples were then submitted to µSBS test using a universal testing machine (Instron 4411) at a crosshead speed of 0.5 mm/min. Data were submitted to three-way ANOVA and Tukey post-hoc test (α=0.05). The mean µSBS at 24 h was significantly higher than after thermal cycling (p<0.05). No statistical difference was found between resin-luting agents (p > 0.05). The mean µSBS for groups photoactivated through 0.5 mm ceramic were significantly higher than 1.5 mm and 2.0 mm (p < 0.05). In conclusion, increased ceramic thicknesses reduced the bond strength of tested resin-luting agents to lithium disilicate. No differences were found between resin-luting agents. Thermal cycling reduced the bond strength of both resin-luting agents. (µSBS (2 dualcured dual cured resinluting resin luting RelyX (RelyX U200 U disilicate emax e max 05 0 5 15 1 obtained 3.0 30 3 (3. cylindershaped cylinder shaped 10 1. diameter strip plate 25 mold singlepeak single peak Radii Plus. Plus oC 3,000 3000 000 (3,00 cycles ºC 55ºC. 55ºC . 55ºC) Instron 4411 0. mmmin min mm/min threeway three way posthoc post hoc α=0.05. α005 α α=0.05 (α=0.05) p<0.05. p005 p p<0.05 (p<0.05) 0.05. 005 0.05 0.05) 20 2. conclusion ( U20 3. (3 3,00 300 00 (3,0 441 α00 α=0.0 (α=0.05 p00 p<0.0 (p<0.05 0.0 U2 3,0 (3, 44 α0 α=0. (α=0.0 p0 p<0. (p<0.0 3, 4 α=0 (α=0. p<0 (p<0. α= (α=0 p< (p<0 (α= (p< (α

Resumo: Este estudo investigou a resistência de união ao microcisalhamento (RUµC) de dois (2) agentes de cimentação de resina dual (RelyX™ Ultimate e RelyX™ U200) quando fotoativados através de diferentes espessuras de dissilicato de lítio, com ou sem ciclagem térmica. Discos do IPS e.max Press de 0,5, 1,5 e 2 mm de espessura foram obtidos. Moldes de elastômero (3,0 mm de espessura) com quatro orifícios cilíndricos de 1,0 mm de diâmetro foram colocados sobre as superfícies cerâmicas e preenchidos com agentes de cimentação de resina. Uma tira Mylar, placa de vidro e carga de 250 gramas foram colocadas sobre o molde preenchido. A carga foi removida e os agentes de cimentação resinosos foram fotoativados através da cerâmica usando um LED de pico-único (Radii Plus). Todas as amostras foram armazenadas em água deionizada a 37oC por 24 h. Metade das amostras foi submetida a ciclagem térmica (3.000 ciclos; 5ºC e 55ºC). Todas as amostras foram então submetidas ao teste de RUµC usando uma máquina de teste universal (Instron 4411) com velocidade de 0,5 mm/min. Os dados foram submetidos à Análise de Variância três fatores e ao teste post-hoc de Tukey (α = 0,05). A média de RUµC em 24 h foi significativamente maior do que após a ciclagem térmica (p < 0,05). Não houve diferença estatística entre os cimentos resinosos (p > 0,05). As médias de RUµC para grupos fotoativados através de cerâmica de 0,5 mm foram significativamente maiores do que 1,5 mm e 2,0 mm (p < 0,05). Em conclusão, o aumento da espessura da cerâmica reduziu a resistência de união dos agentes de cimentação resinosos ao dissilicato de lítio. Não foram encontradas diferenças entre os agentes de cimentação resinosos. A ciclagem térmica reduziu a resistência de união de ambos os agentes de cimentação resinosos. Resumo (RUµC (2 RelyX (RelyX U200 U lítio emax max 05 0 5 15 1 1, obtidos 3,0 30 3 (3, 10 Mylar 25 preenchido picoúnico pico único Radii Plus. Plus . Plus) oC 3.000 3000 000 (3.00 ciclos ºC 55ºC. 55ºC 55ºC) Instron 4411 0, mmmin min mm/min posthoc post hoc α 0,05. 005 0,05 0,05) p 20 2, conclusão ( U20 3, (3 3.00 300 00 (3.0 441 0,0 U2 3.0 (3. 44 3. 4

Abstract To evaluate the impact of genetic polymorphisms in interleukins (IL1A rs17561, rs1304037; IL10 rs1800871; IL1RN rs9005), nitric oxide (NOS2 rs2779249, rs2897518) and suppressor of cytokine signaling (SOCS1 rs243327, rs33977706) on oral health-related quality of life (OHRQoL) of patients under-going root canal treatment (RCT). Methods: The sample consisted of 108 participants, presenting single-rooted teeth with asymptomatic periapical periodontitis. The impact of the OHRQoL was recorded using the Oral Health Impact Profile (OHIP-14) before, seven, and 30 days after RCT. Saliva samples were collected as a source of genomic DNA. Genetic polymorphisms were genotyped by Real-Time PCR using the Taqman method. Univariate and Multivariate analyses were used (p<0.05). Results: A significant difference was observed for the polymorphism rs2297518 in the NOS2 gene in functional limitation in the codominant (p=0.037) and recessive (p=0.001) models; in the physical pain (p<0.001 in both models); in psychological discomfort (p<0.001 in both models); in physical disability (p<0.001 in both models) and in psychological disability (p<0.001 in both models). Polymorphisms in the SOCS1 gene, in the recessive model, rs33977706 (p=0.045) and rs243327 (p=0.019), influenced the OHRQoL in the psychological discomfort domain. Conclusions: Polymorphisms in NOS2 and SOCS1 genes influenced the OHRQoL of patients undergoing RCT. IL1A ILA IL rs17561 rs rs1304037 IL1 rs1800871 ILRN RN rs9005, rs9005 , rs9005) NOS (NOS rs2779249 rs2897518 SOCS (SOCS healthrelated health related (OHRQoL under going RCT . (RCT) Methods 10 participants singlerooted single rooted periodontitis OHIP14 OHIP 14 (OHIP-14 before seven 3 DNA RealTime Real Time method p<0.05. p005 p p<0.05 0 05 (p<0.05) Results rs229751 p=0.037 p0037 037 (p=0.037 p=0.001 p0001 001 (p=0.001 models p<0.001 (p<0.00 models. model rs3397770 p=0.045 p0045 045 (p=0.045 rs24332 p=0.019, p0019 p=0.019 019 (p=0.019) domain Conclusions rs1756 rs130403 rs180087 rs900 rs277924 rs289751 (RCT 1 OHIP1 (OHIP-1 p00 p<0.0 (p<0.05 rs22975 p=0.03 p003 03 (p=0.03 p=0.00 p000 00 (p=0.00 p<0.00 (p<0.0 rs339777 p=0.04 p004 04 (p=0.04 rs2433 p001 p=0.01 01 (p=0.019 rs175 rs13040 rs18008 rs90 rs27792 rs28975 (OHIP- p0 p<0. rs2297 p=0.0 (p=0.0 (p<0. rs33977 rs243 (p=0.01 rs17 rs1304 rs1800 rs9 rs2779 rs2897 (OHIP p<0 rs229 p=0. (p=0. (p<0 rs3397 rs24 rs1 rs130 rs180 rs277 rs289 p< rs22 p=0 (p=0 (p< rs339 rs2 rs13 rs18 rs27 rs28 p= (p= (p rs33 rs3

Resumo Avaliar o impacto de polimorfismos genéticos em interleucinas (IL1A rs17561, rs1304037; IL10 rs1800871; IL1RN rs9005), óxido nítrico (NOS2 rs2779249, rs2897518) e supressor da sinalização de citocinas (SOCS1 rs243327, rs33977706) na qualidade de vida relacionada à saúde bucal (QVRSB) de pacientes submetidos a tratamento endodôntico (TE). Métodos: A amostra foi composta por 108 participantes, que apresentavam dentes unirradiculares com lesão periapical assintomática. O impacto da QVRSB foi registrado usando o Oral Health Impact Profile (OHIP-14) antes, sete e 30 dias após o TE. Amostras de saliva foram coletadas como fonte de DNA genômico. Os polimorfismos genéticos foram genotipados por PCR em tempo real usando o método Taqman. Análises univariadas e multivariadas foram utilizadas (p<0,05). Resultados: Observou-se diferença significativa para o polimorfismo rs2297518 no gene NOS2 na limitação funcional nos modelos codominante (p=0,037) e recessivo (p=0,001); na dor física (p<0,001 em ambos os modelos); no desconforto psicológico (p<0,001 em ambos os modelos); na deficiência física (p<0,001 em ambos os modelos) e na deficiência psicológica (p<0,001 em ambos os modelos). Polimorfismos no gene SOCS1, no modelo recessivo, rs33977706 (p=0,045) e rs243327 (p=0,019), influenciaram a QVRSB no domínio desconforto psicológico. Conclusões: Polimorfismos nos genes NOS2 e SOCS1 influenciaram a QVRSB de pacientes submetidos a TE. IL1A ILA IL rs17561 rs rs1304037 IL1 rs1800871 ILRN RN rs9005, rs9005 , rs9005) NOS (NOS rs2779249 rs2897518 SOCS (SOCS (QVRSB TE . (TE) Métodos 10 participantes assintomática OHIP14 OHIP 14 (OHIP-14 antes 3 genômico Taqman p<0,05. p005 p p<0,05 0 05 (p<0,05) Resultados Observouse Observou se rs229751 p=0,037 p0037 037 (p=0,037 p=0,001 p0001 001 (p=0,001) p<0,001 (p<0,00 modelos. rs3397770 p=0,045 p0045 045 (p=0,045 rs24332 p=0,019, p0019 p=0,019 019 (p=0,019) Conclusões rs1756 rs130403 rs180087 rs900 rs277924 rs289751 (TE 1 OHIP1 (OHIP-1 p00 p<0,0 (p<0,05 rs22975 p=0,03 p003 03 (p=0,03 p=0,00 p000 00 (p=0,001 p<0,00 (p<0,0 rs339777 p=0,04 p004 04 (p=0,04 rs2433 p001 p=0,01 01 (p=0,019 rs175 rs13040 rs18008 rs90 rs27792 rs28975 (OHIP- p0 p<0, rs2297 p=0,0 (p=0,0 (p=0,00 (p<0, rs33977 rs243 (p=0,01 rs17 rs1304 rs1800 rs9 rs2779 rs2897 (OHIP p<0 rs229 p=0, (p=0, (p<0 rs3397 rs24 rs1 rs130 rs180 rs277 rs289 p< rs22 p=0 (p=0 (p< rs339 rs2 rs13 rs18 rs27 rs28 p= (p= (p rs33 rs3

Abstract Rendu-Osler-Weber syndrome, also known as hereditary hemorrhagic telangiectasia, is an autosomal dominant hereditary disorder. It is characterized by presence of multiple arteriovenous malformations (AVMs) and telangiectasias. This article reports two cases of patients with Rendu-Osler-Weber syndrome who had pulmonary AVMs and underwent successful endovascular treatment. A brief review of the literature shows that up to 50% of patients with the syndrome have pulmonary AVMs and there is usually a positive family history in these patients. These pulmonary AVMs are multiple in 30% of cases and are associated with the most severe disease complications. Most patients are asymptomatic, even in the presence of AVMs with right-left shunts. When these shunts exceed 25% of the total blood volume, dyspnea, cyanosis, digital clubbing, and extracardiac murmurs may occur. Endovascular treatment is safe and offers control of complications from hereditary hemorrhagic telangiectasia and is currently the treatment of choice for these lesions. RenduOslerWeber Rendu Osler Weber disorder (AVMs telangiectasias 50 30 asymptomatic rightleft right left 25 volume dyspnea cyanosis clubbing occur lesions 5 3 2

Resumo A síndrome de Rendu-Osler-Weber, também conhecida como telangiectasia hemorrágica hereditária, é uma doença hereditária autossômica dominante. Ela é caracterizada pela presença de múltiplas malformações arteriovenosas e telangiectasias. Este artigo relata dois casos de pacientes com síndrome de Rendu-Osler-Weber que apresentaram malformações arteriovenosas pulmonares e foram submetidos a tratamento endovascular com sucesso. Uma breve revisão da literatura mostra que até 50% dos pacientes com a síndrome têm malformações arteriovenosas pulmonares e geralmente há um histórico familiar positivo nesses pacientes. Em 30% dos casos, elas são múltiplas e estão associadas a complicações mais graves da doença. A maioria dos pacientes é assintomática, mesmo na presença de malformações arteriovenosas com shunt direito-esquerdo. Quando esses shunts excedem 25% do volume total de sangue, podem surgir dispneia, cianose, baqueteamento digital e sopros extracardíacos. O tratamento endovascular oferece segurança e controle das complicações da telangiectasia hemorrágica hereditária, sendo atualmente o tratamento de escolha para essas lesões. RenduOslerWeber, RenduOslerWeber Rendu Osler Weber, Weber dominante telangiectasias sucesso 50 30 assintomática direitoesquerdo. direitoesquerdo direito esquerdo. esquerdo direito-esquerdo 25 sangue dispneia cianose extracardíacos lesões 5 3 2

Schinus terebinthifolius Raddi (Anacardiaceae), commonly known as “pimenta rosa”, “aroeira da praia”, “aroeira”, “aroeirinha”, and “cabuí” is frequently used in traditional medicine to address various conditions, including skin wounds, ulcers, tumors, diarrhea, arthritis, as well as urinary and respiratory tract infections. This study aimed to develop and validate an analytical method using high-performance liquid chromatography with diode array detector (HPLC-DAD) for quantifying gallic acid (GA) in methanolic extracts of S. terebinthifolius leaves, branches, and fruits. The chromatographic separations utilized a reversed-phase Zorbax Eclipse XDB-C18 column with an isocratic elution mode of acetonitrile/methanol/water acidified with 0.2% formic acid. The flow rate was 0.8 mL min-1, and detection occurred at 254 nm. The developed HPLC-DAD method demonstrated selectivity, with a GA retention time of 5.263 min and absorption maxima at 220 and 271 nm. The method exhibited high linearity (coefficient of 0.9996), precision (relative standard deviation (RSD) values < 5%), and robustness. Accuracy ranged from 100.28 to 111.71%, with an average recovery of 105.41% and an average RSD of 3.46%. These validated results play a crucial role in assessing and standardizing raw materials containing S. terebinthifolius, emphasizing the reliability of the developed HPLC-DAD method for GA quantification in different plant parts. Anacardiaceae, Anacardiaceae , (Anacardiaceae) pimenta rosa, rosa rosa” aroeira praia, praia praia” aroeira, “aroeira” aroeirinha, aroeirinha “aroeirinha” cabuí “cabuí conditions wounds ulcers tumors diarrhea arthritis infections highperformance performance HPLCDAD HPLC DAD (HPLC-DAD (GA S leaves branches fruits reversedphase reversed phase XDBC18 XDBC XDB C18 C XDB-C1 acetonitrilemethanolwater acetonitrile methanol water 02 0 2 0.2 08 8 0. min1, min1 1, 1 min-1 25 nm selectivity 5263 5 263 5.26 22 27 coefficient 0.9996, 09996 0.9996 9996 0.9996) relative (RSD 5%, 5% 5%) robustness 10028 100 28 100.2 11171 111 71 111.71% 10541 105 41 105.41 346 3 46 3.46% parts (Anacardiaceae “aroeirinha XDBC1 C1 XDB-C min- 526 26 5.2 0999 0.999 999 1002 10 100. 1117 11 7 111.71 1054 4 105.4 34 3.46 52 5. 099 0.99 99 111.7 105. 3.4 09 0.9 9 111. 3.

Abstract The aim of this study was to evaluate whether polymorphisms in SOD2 and SOD3 genes modulate the oral health-related quality of life (OHRQoL) of Para athletes with dental caries experience. The cross-sectional study included 264 Para athletes (143 in athletics, 61 in weightlifting and 60 in swimming). A trained and calibrated team recorded the decayed, missing and filled teeth index (DMFT). The Brazilian version of the Oral Health Impact Profile (OHIP-14) was used to measure OHRQoL. Genomic DNA was extracted from the athletes’ saliva, and genetic polymorphisms in the SOD2 (rs5746136 and rs10370) and SOD3 (rs2855262 and rs13306703) genes were analyzed by real-time polymerase chain reaction. Univariate and multivariate analyses were performed. A multivariate General Linear Model analysis, adjusted for sex, revealed that the SOD3 gene polymorphism (rs2855262) had a significant effect on the psychological disability domain [codominant (p = 0.045) and recessive (p=0.038) models]. The SOD2 gene polymorphism (rs5746136) had a significant effect on the total OHIP-14 score [dominant model (p = 0.038)] and the psychological discomfort [dominant model (p = 0.034)] and physical disability [codominant model (p=0.037)] domains. Presence of the SOD2 rs10370 polymorphism led to statistical differences in the total score [codominant (p = 0.026) and dominant (p = 0.023) models] and the handicap domain scores [codominant (p = 0.027) and dominant (p = 0.032) models]. Polymorphisms of the SOD2 and SOD3 genes may be important biomarkers of OHRQoL in Para athletes with dental caries experience. SOD healthrelated health related (OHRQoL experience crosssectional cross sectional 26 143 (14 athletics 6 swimming. swimming . swimming) decayed DMFT. DMFT (DMFT) OHIP14 OHIP 14 (OHIP-14 saliva rs5746136 rs (rs574613 rs2855262 (rs285526 rs13306703 realtime real time reaction performed analysis sex codominant p 0.045 0045 0 045 p=0.038 p0038 038 (p=0.038 models. models OHIP-1 0.038 0038 0.038) 0.034 0034 034 0.034) p=0.037 p0037 037 (p=0.037) domains rs1037 0.026 0026 026 0.023 0023 023 0.027 0027 027 0.032 0032 032 2 (1 (DMFT OHIP1 1 (OHIP-1 rs574613 (rs57461 rs285526 (rs28552 rs1330670 0.04 004 04 p=0.03 p003 03 (p=0.03 OHIP- 0.03 003 (p=0.037 rs103 0.02 002 02 ( (OHIP- rs57461 (rs5746 rs28552 (rs2855 rs133067 0.0 00 p=0.0 p00 (p=0.0 rs10 (OHIP rs5746 (rs574 rs2855 (rs285 rs13306 0. p=0. p0 (p=0. rs1 rs574 (rs57 rs285 (rs28 rs1330 p=0 (p=0 rs57 (rs5 rs28 (rs2 rs133 p= (p= rs5 (rs rs2 rs13

Campomanesia adamantium is native of the Brazilian Cerrado, and its leaves are popularly used as anti-infammatory, antidiarrheal, and antiseptic in the urinary tract. This study aimed to develop and validate an analytical method by high-performance liquid chromatography for the simultaneous quantifcation and evaluation of the seasonal variability of gallic acid, catechin, and epicatechin, during 12 months, in C. adamantium leaf extracts. Chromatographic separations were performed with a mobile phase gradient of acetonitrile and 0.05% (v/v) trifuoroacetic acid solution, fow rate of 1.0 mL min−1, detection at 210 nm, C18 column (150 × 4.6 mm, 5 μm) and column oven temperature of 35 °C. The analytical method developed was selective, linear, precise, accurate, robust, and without matrix effect. The parameters obtained in the present study meet the requirements established by national and international guidelines. The best time for leaves harvesting, with the highest levels reached, was in September (0.0626%, m/v) and August (0.044%, m/v) for gallic acid, in June (0.3953%, m/v) and July (0.3804%, m/v) for catechin, and from May (0.1622%, m/v) and June (0.1415%, m/v) for epicatechin, in the dry season. Therefore, this study contributes by providing parameters for quality control of the raw material C. adamantium. Cerrado antiinfammatory, antiinfammatory anti infammatory, infammatory anti-infammatory antidiarrheal tract highperformance high performance catechin epicatechin 1 months C extracts 005 0 05 0.05 v/v vv v (v/v solution 10 1. min1 min min−1 21 nm C1 150 (15 46 4 6 4. mm μm 3 °C selective linear precise accurate robust effect guidelines harvesting reached 0.0626%, 00626 0626 (0.0626% m/v mv m 0.044%, 0044 044 (0.044% 0.3953%, 03953 3953 (0.3953% 0.3804%, 03804 3804 (0.3804% 0.1622%, 01622 1622 (0.1622% 0.1415%, 01415 1415 (0.1415% season Therefore 00 0.0 min− 2 15 (1 0.0626% 0062 062 (0.0626 0.044% 004 04 (0.044 0.3953% 0395 395 (0.3953 0.3804% 0380 380 (0.3804 0.1622% 0162 162 (0.1622 0.1415% 0141 141 (0.1415 0. ( 0.0626 006 06 (0.062 0.044 (0.04 0.3953 039 39 (0.395 0.3804 038 38 (0.380 0.1622 016 16 (0.162 0.1415 014 14 (0.141 0.062 (0.06 0.04 (0.0 0.395 03 (0.39 0.380 (0.38 0.162 01 (0.16 0.141 (0.14 0.06 (0. 0.39 (0.3 0.38 0.16 (0.1 0.14 (0 0.3 0.1

In this work, the molecular properties of the (E)-3-(4-nitrobenzylidene)-2-(4-methoxyphenyl)-2,3-dihydro-1-(phenylsulfonyl)-quinolin-4(1H)-one were studied, both in a solid and isolated state. The effect of changing the substituent groups –OCH3 and –Cl in the phenyl portion was verified, where the structural and electronic properties were compared. The density functional theory was employed using the hybrid exchange-correlation functional with long-range correction M06-2X, combined with the polarized and diffuse basis set 6-311++G(d,p), in the gas phase. The electronic structure was also analyzed by frontier molecular orbitals and molecular electrostatic potential maps, where information about its chemical reactivity was obtained. Also, the supramolecular arrangement was analyzed by Hirshfeld surface (HS), 2D fingerprint plots, and quantum theory of atoms in molecules (QTAIM). The natural bond orbitals (NBO) calculations were carried out to analyze the stability and hyperconjugation energy. Finally, molecular docking was carried out to investigate the affinities of the quinoline-chalcone with a bacterial protein (Agrobacterium pathogens) and an ecdysone receptor-potential pesticidal activity. The results encourage further in vitro and in vivo analyses of the two kinds of organisms investigated. work E34nitrobenzylidene24methoxyphenyl2,3dihydro1phenylsulfonylquinolin41Hone E34nitrobenzylidene24methoxyphenyl23dihydro1phenylsulfonylquinolin41Hone EnitrobenzylidenemethoxyphenyldihydrophenylsulfonylquinolinHone E 3 4 nitrobenzylidene 2 methoxyphenyl 2,3 dihydro 1 phenylsulfonyl quinolin 1H one H studied state OCH3 OCH –OCH Cl verified compared exchangecorrelation exchange correlation longrange long range M062X, M062X MX M06 2X, 2X M X M06-2X 6311++Gd,p, 6311Gdp Gdp 6 311++G d,p , 311 G d p 6-311++G(d,p) phase maps obtained Also HS, HS (HS) D plots QTAIM. QTAIM . (QTAIM) NBO (NBO energy Finally quinolinechalcone quinoline chalcone Agrobacterium pathogens receptorpotential receptor activity investigated E34nitrobenzylidene24methoxyphenyl2 3dihydro1phenylsulfonylquinolin41Hone phenylsulfonylquinolin Hone 23 2, M0 6311 Gd 6311++Gd,p 311G dp 31 6-311++G(d,p (HS (QTAIM Enitrobenzylidenemethoxyphenyl E34nitrobenzylidene24methoxyphenyl dihydrophenylsulfonylquinolinHone 631 63

ABSTRACT We investigated the influence of poultry rearing factors, including strain, type of ventilation, and sex on the slaughter characteristics of broiler chickens. Factorial analysis of mixed data was employed to analyze the data from broiler flocks slaughtered between 2018 and 2020 in Mato Grosso do Sul, comprising 2,684 flocks and 82,486,500 birds. The characterization information considered included age at slaughter, average weight, date of slaughter, percentage of pododermatitis, percentage of scratches, percentage of pre-slaughter condemnations, percentage of slaughter condemnations, percentage of total condemnation, percentage of field mortality, type of ventilation, strain, and sex. The factorial analysis of mixed data aimed to identify the relationships between pre-slaughter factors and slaughter characteristics. Five main components, explaining 85.5% of the total data variance, were derived from the analysis. Age, generated value per kilo of product, and percentage of pre-slaughter condemnations exhibited positive correlations. Negative pressure ventilation was found to be more closely associated with the percentage of pododermatitis, while the dark house system showed a stronger association with the percentage of total condemnation and percentage of pre-slaughter condemnation. The Cobb strain and female sex were found to be more strongly related to the generated value of the product. Strain, sex, and type of ventilation were identified as decisive factors influencing the characteristics of meat yields and the economic results of poultry activity in slaughterhouses. Moreover, it was observed that percentages of scratches and pododermatitis were negatively correlated with the value generated ($/kg) by broiler flocks, and they were more closely associated with positive pressure ventilation systems, Ross strain, mixtures of strains within the same flock, and male chickens. It was possible to prove the strong interdependence between the rearing stage of broiler chickens and the slaughterhouse, which needs to be considered in decision making by agroindustry to achieve an ideal rearing model. 201 202 Sul 2684 2 684 2,68 82486500 82 486 500 82,486,50 birds weight preslaughter pre mortality components 855 85 5 85.5 variance Age product correlations Strain slaughterhouses Moreover $/kg kg ($/kg systems flock slaughterhouse model 20 268 68 2,6 8248650 8 48 50 82,486,5 85. 26 6 2, 824865 4 82,486, 82486 82,486 8248 82,48 824 82,4 82,

ABSTRACT Purpose: To analyze the average time between submission and acceptance of national journals in seven Brazilian surgery journals from 2017 to 2022. Methods: It consists of a cross-sectional and observational study with a quantitative approach to analyze the acceptance time of articles approved by Brazilian journals on general surgery and its subspecialties, including Acta Cirúrgica Brasileira, Jornal Vascular Brasileiro, Arquivos Brasileiros de Cirurgia de Digestiva, Revista do Colégio Brasileiro de Cirurgiões, Journal of Coloproctology, Revista Brasileira de Cirurgia Plástica, and International Brazilian Journal of Urology. Results: The journals with the lowest average waiting times were Revista do Colégio Brasileiro de Cirurgiões, Acta Cirúrgica Brasileira, and Journal of Coloproctology, respectively, and, with the lowest interquartile range there is Acta Cirúrgica Brasileira. There was no significant difference between the pre-pandemic and pandemic periods. The study designs with the highest and lowest means were, respectively, ideas and innovations – also with the highest interquartile range – and expert opinion, while with the lowest interquartile range was technical skill. Conclusions: The acceptance time for articles in Brazilian surgery journals is extremely variable. Identifying these discrepancies highlights the importance of understanding editorial processes and seeking ways to improve consistency and efficiency in reviewing articles. Purpose 201 2022 Methods crosssectional cross sectional subspecialties Digestiva Cirurgiões Coloproctology Plástica Urology Results respectively prepandemic pre periods opinion skill Conclusions variable 20 202 2

Abstract The larynx is in the lower respiratory tract and has the function of protecting the airways, controlling, and modulating breathing, assisting the circulatory system, and vocalizing. This study aims to describe the anatomy and histology of the skeleton of the larynx and trachea of the species Chelonia mydas, Caiman yacare and Caiman latirostris. The study was conducted at the Federal University of Espírito Santo (UFES), using nine specimens of Ch. mydas, 20 of Ca. yacare and four of Ca. latirostris. Samples of the larynx and trachea were collected, fixed, and sent for dissection of the structures and subsequent macroscopic analysis. For histology, samples were processed by the routine paraffin embedding method and stained with hematoxylin-eosin and Verhoeff. For the three species, two arytenoid cartilages, a cricoid cartilage, a hyoid apparatus composed of a base and two horns were found. In Ch. mydas, two structures called thyroid wings were observed, not found in crocodilians. The trachea of crocodilians presented incomplete tracheal rings and musculature, while the trachea of Ch. mydas presented complete tracheal rings. Histologically, the entire cartilaginous skeleton of the larynx of the three species, as well as the tracheal rings, are constituted by hyaline cartilage. airways controlling breathing system vocalizing latirostris UFES, UFES , (UFES) Ch 2 Ca collected fixed analysis hematoxylineosin hematoxylin eosin Verhoeff cartilages cartilage observed musculature Histologically (UFES

Abstract Background In general, patients are referred for rheumatological evaluation due to isolated laboratory abnormalities, especially antinuclear antibody (ANA) positivity, with the risk of more severe patients remaining on the waiting list for longer than desired. The aim of this study was to analyze the demographic, clinical, and laboratory information of patients referred to a specialized rheumatological care unit because of positive antinuclear antibody. Methods This is a retrospective study of 99 out of 1670 patients seen by the same rheumatologist between 01/01/2011 and 01/01/2019. Patients whose referrals were exclusively due to the ANA test result and the specialist’s final diagnosis being “abnormal finding of serum immunological test” (ICD-10 R769) were included. Sociodemographic, clinical, and laboratory information were extracted from the consulting rheumatologist’s chart. Descriptive statistics were used for data analysis. Results A total of 99 patients were included, most of whom were female (84.8%) with a median age of 49 years. At the moment of specialist’s appointment, 97 patients (97.9%) repeated the ANA test, and 77 patients remained positive. Of these, only 35 (35.35%) were in a high titer range (greater than or equal to 1:320). Complete blood count for cytopenia’s investigation was not performed in a high percentage of patients (22.2%), as well as urinalysis (31.3%). In addition, more than 70% of patients score 0 to 1 classification criteria for Systemic Lupus Erythematosus, according to SLE - ACR 1987 (American College of Rheumatology) and SLICC 2012 (Systemic Lupus International Collaborating Clinics). Conclusions Most patients are still referred for specialized evaluation due to the misinterpretation of laboratory tests that were inappropriately requested in patients without clinical evidence of autoimmune rheumatic disease. general abnormalities (ANA positivity desired demographic 9 167 01012011 01 2011 01/01/201 01012019 2019 01/01/2019 specialists specialist s abnormal ICD10 ICD 10 (ICD-1 R769 R included Sociodemographic rheumatologists chart analysis 84.8% 848 84 8 (84.8% 4 years appointment 97.9% 979 (97.9% 7 these 3 35.35% 3535 (35.35% greater 1320. 1320 320 . 1:320) cytopenias cytopenia 22.2%, 222 22.2% , 22 2 (22.2%) 31.3%. 313 31.3% 31 (31.3%) addition 70 Erythematosus 198 American Rheumatology 201 Clinics. Clinics Clinics) disease 16 0101201 01/01/20 ICD1 (ICD- R76 84.8 (84.8 97.9 (97.9 35.35 353 (35.35 132 32 1:320 22.2 (22.2% 31.3 (31.3% 19 20 010120 01/01/2 (ICD R7 84. (84. 97. (97. 35.3 (35.3 13 1:32 22. (22.2 31. (31.3 01012 01/01/ (84 (97 35. (35. 1:3 (22. (31. 0101 01/01 (8 (9 (35 1: (22 (31 010 01/0 ( (3 (2 01/

ABSTRACT Objective: To evaluate the impact of endodontic treatment with photobiomodulation on oral health-related quality of life (HRQoL). Material and Methods: Seventy participants with single-rooted teeth and a diagnosis of asymptomatic apical periodontitis were selected and randomized into two groups: control group (CG, n = 35), root canal treatment without additional treatment, and experimental group (EG, n = 35), root canal treatment associated with antimicrobial photodynamic therapy and low-level laser therapy. OHRQoL was assessed using the Oral Health Impact Profile Questionnaire (OHIP-14) at baseline and 7 and 30 days after treatment. Data were subjected to Wilcoxon, Mann-Whitney tests, and linear regression using the generalized estimating equation model, using the Statistical Package for Social Science software with a significance level of 5%. Results: No statistically significant differences were found between groups regarding sociodemographic and clinical characteristics (p>0.05). There was also no difference in the OHRQoL between the CG and EG (p>0.05). However, there was a statistical difference in OHIP-14 scores between baseline and the 7- and 30-day follow-up intervals in both groups for all domains (p<0.05). Conclusion: Root canal treatment, with or without photobiomodulation, significantly improved the OHRQoL of participants after 7 and 30 days of treatment. Objective healthrelated health related HRQoL. HRQoL . (HRQoL) Methods singlerooted single rooted CG, (CG 35, 35 , 35) EG, (EG lowlevel low OHIP14 OHIP 14 (OHIP-14 3 Wilcoxon MannWhitney Mann Whitney tests model 5 5% Results p>0.05. p005 p p>0.05 0 05 (p>0.05) However OHIP-1 30day day followup follow up p<0.05. p<0.05 (p<0.05) Conclusion (HRQoL OHIP1 1 (OHIP-1 p00 p>0.0 (p>0.05 OHIP- p<0.0 (p<0.05 (OHIP- p0 p>0. (p>0.0 p<0. (p<0.0 (OHIP p>0 (p>0. p<0 (p<0. p> (p>0 p< (p<0 (p> (p< (p