Resumo Obras de arte especiais com elementos estruturais mistos de aço e concreto consistem em uma solução popular, uma vez que tais elementos combinam os benefícios estruturais do aço e do concreto. Em pontes de pequenos e médios vãos, a solução que usualmente garante resultados econômicos interessantes é composta por uma laje de concreto sobre vigamento de aço em perfis I. Outras opções que despontam como alternativas eficientes na construção de obras de arte especiais são o sistema de vigas com conectores de cisalhamento em chapa de aço contínua recortada e o sistema de vigas mistas preflexionadas. Diante disso, o presente trabalho tem por objetivo a realização de um estudo comparativo das diferentes soluções de vigas mistas a fim de delimitar a performance das soluções propostas. Para tanto, o estudo de caso da superestrutura de uma ponte ferroviária de duas vias com vão biapoiado é apresentada em detalhes para definir os indicadores de desempenho das soluções. As soluções de vigas mistas propostas apresentaram vantagens quando comparadas com o sistema tradicional, demonstrando o impacto positivo de seu uso no contexto das obras de arte especiais. popular vãos I preflexionadas disso tanto tradicional

Abstract Steel-concrete composite bridges are a popular solution due to the structural benefits of both steel and concrete. The typical system of a concrete slab and steel I-girders for small and medium-span bridges often displays the most economical results. However, other solutions emerge as innovative alternatives for bridge construction, such as composite beams with composite dowels and pre-cambered composite beams. This paper aims to develop a comparative study of these composite beam solutions to delimitate their efficiency, performance, and economy. Thus, a case study for the superstructure of a two-way simply supported railway bridge is detailed to define the composite beam’s performance indicators. The innovative alternatives presented benefits when compared to the traditional system, demonstrating the positive impact of their use on bridges. Steelconcrete Steel Igirders I girders mediumspan medium span results However construction precambered pre cambered efficiency economy Thus twoway two way s indicators

ABSTRACT Objective To evaluate deaths, hospitalizations, and persistence of symptoms in patients with COVID-19 after infection in an outpatient setting during the first COVID-19 wave in Brazil. Methods This prospective cohort was between April 2020 and February 2021. Hospitalized or non-hospitalized COVID-19 patients until five days after symptom onset were included. The outcomes measured were incidence of death, hospitalization, and persistence of more than two symptoms 60 days after discharge. Results Out of 1,198 patients enrolled in the study, 66.7% were hospitalized. A total of 289 patients died (1 [0.3%] non-hospitalized and 288 [36%] hospitalized). At 60 days, patients non-hospitalized during admission had more persistent symptoms (16.2%) compared to hospitalized (37.1%). The COVID-19 severity variables associated with the persistence of two or more symptoms were increased age (OR= 1.03; p=0.015), respiratory rate at hospital admission (OR= 1.11; p=0.005), length of hospital stay of more than 60 days (OR= 12.24; p=0.026), and need for intensive care unit admission (OR= 2.04; p=0.038). Conclusion COVID-19 survivors who were older, tachypneic at admission, had a hospital length of stay >60 days, and were admitted to the intensive care unit had more persistent symptoms than patients who did not require hospitalization in the early COVID-19 waves. ClinicalTrials.gov Identifier: NCT04479488. deaths hospitalizations COVID19 COVID 19 COVID-1 Brazil 202 2021 nonhospitalized non included death 6 discharge 1198 1 198 1,19 study 667 66 7 66.7 28 ( 0.3% 03 0 3 [0.3% 36% 36 [36% . hospitalized) 16.2% 162 16 2 (16.2% 37.1%. 371 37.1% 37 (37.1%) OR= OR (OR 1.03 103 p=0.015, p0015 p p=0.015 , 015 p=0.015) 1.11 111 11 p=0.005, p0005 p=0.005 005 p=0.005) 12.24 1224 12 24 p=0.026, p0026 p=0.026 026 p=0.026) 2.04 204 04 p=0.038. p0038 p=0.038 038 p=0.038) older >6 waves ClinicalTrialsgov ClinicalTrials gov Identifier NCT04479488 NCT COVID1 COVID- 20 119 1,1 66. 0.3 [0.3 [36 16.2 (16.2 37.1 (37.1% 1.0 10 p001 p=0.01 01 1.1 p000 p=0.00 00 12.2 122 p002 p=0.02 02 2.0 p003 p=0.03 > NCT0447948 1, 0. [0. [3 16. (16. 37. (37.1 1. p00 p=0.0 12. 2. NCT044794 [0 [ (16 (37. p0 p=0. NCT04479 (37 p=0 NCT0447 (3 p= NCT044 NCT04 NCT0

ABSTRACT Since the industrial revolution, human activities have emitted approximately 2,500 Gt of CO2, increasing the concentration of atmospheric CO2 by 50 % compared to pre-industrial levels. To better understand the potential for mitigating greenhouse gas (GHG) emissions through proper management of degraded pasture areas, we conducted a systematic literature review and identified 23 publications reporting carbon sequestration values for pastures managed under different conditions in the south and southeast regions of Brazil. From this dataset, 17 publications considered to be in line with the research premises were selected to estimate the potential for soil carbon sequestration (SEQ) through pasture recovery in the southern region of Brazil, using conservative and regenerative agricultural management practices. Results show that managed pastures can sustain carbon sequestration rates of around 2.50 Mg C ha-1 yr-1 over approximately 20 years. However, due to the numerous variables influencing SEQ rates, the limited number of publications, and the lack of data for some variables among them, a more extensive analysis of publications and data is needed to establish causal and preponderance relationships regarding the effect of each variable on the found SEQ rates. Under current pasture occupation conditions in Brazil’s south region, it is estimated these areas could sequester between 0.433 and 1.273 Gt CO2 at the end of 20 years if managed under appropriate practices. These numbers are not representative to reduce atmospheric CO2 concentration from legacy emissions and significantly mitigate physical impacts of climate change, reinforcing the importance of prioritizing the reduction of global GHG emissions as the primary mitigation strategy. On the other hand, from the perspective of mitigating the national agricultural sector’s annual GHG emissions, this potential cannot be considered negligible. Carbon sequestration by soils under agricultural management can play a vital role in mitigating climate change, integrating the set of necessary solutions and actions for a Paris Agreement goals compatible trajectory of limiting global warming to between 1.5 and 2 °C by the end of the century. revolution 2500 500 2,50 CO 5 preindustrial pre levels (GHG Brazil dataset 1 (SEQ practices 250 2.5 ha1 ha ha- yr1 yr yr- However them Brazils s 0433 0 433 0.43 1273 273 1.27 change strategy hand sectors sector negligible 15 1. century 2,5 25 2. 043 43 0.4 127 27 1.2 2, 04 4 0. 12

RESUMO Objetivo Determinar a acurácia diagnóstica do Exame Cognitivo de Addenbrooke (ACE-R) para idosos com baixa escolaridade, sem demência, em duas capitais no nordeste do Brasil, comparando a sujeitos com CCL. Métodos Foram coletados 100 participantes a partir de uma avaliação neurológica e psiquiátrica prévia, sendo submetidos aos ACE-R posteriormente. Dentre eles, 18 sujeitos com comprometimento cognitivo leve amnéstico (aCCL), 22 com comprometimento cognitivo leve não amnéstico (naCCL) e 60 controles saudáveis. Resultados Os pontos de acurácia do ACE-R foram considerados excelentes para a comparação entre controles e naCCL [Área sob a curva (AUC) = 0,919)] e controles e aCCL (AUC= 0,921); por outro lado, foi relatada uma baixa acurácia para a comparação entre aCCL e naCCL (AUC= 0,578). Conclusões Os achados dão suporte à necessidade de estudos estabelecendo pontos de corte confiáveis para a avaliação cognitiva de idosos com baixa escolaridade e declínio cognitivo sem demência, levando-se em consideração variáveis ecológicas e regionais. ACER ACE R (ACE-R demência Brasil CCL 10 prévia posteriormente eles 1 aCCL, , (aCCL) 2 (naCCL 6 saudáveis Área AUC (AUC 0,919 0919 0 919 0,919) AUC= 0,921 0921 921 0,921) lado 0,578. 0578 0,578 . 578 0,578) levandose levando se regionais (aCCL 0,91 091 91 0,92 092 92 057 0,57 57 0,9 09 9 05 0,5 5 0,

ABSTRACT Objective To determine the diagnostic accuracy of the Addenbrooke’s Cognitive Examination (ACE-R) for older adults with low education, without dementia, in two capitals in northeastern Brazil, compared to subjects with MCI. Methods 100 participants were collected from a previous neurological and psychiatric evaluation and were subsequently subjected to the ACE-R. Among them, 18 subjects with amnestic mild cognitive impairment (aMCI), 22 with non-amnestic mild cognitive impairment (naMCI), and 60 healthy controls. Results Optimal ACE-R accuracy yielded excellent values for the comparison between controls and naMCI [Area Under the Curve (AUC) = 0.919)] and controls and aMCI (AUC= 0.921); conversely, very fair accuracy was reported for the comparison between aMCI and naMCI (AUC= 0.578). Conclusions These findings support establishing reliable cutoff scores for cognitive assessment of elderlies with low schooling and cognitive decline, not dementia, taking into consideration ecological and regional variables. Addenbrookes Addenbrooke s ACER ACE R (ACE-R education dementia Brazil MCI 10 ACER. R. them 1 aMCI, , (aMCI) 2 nonamnestic non naMCI, (naMCI) 6 Area AUC (AUC 0.919 0919 0 919 0.919) AUC= 0.921 0921 921 0.921) conversely 0.578. 0578 0.578 . 578 0.578) decline variables (aMCI (naMCI 0.91 091 91 0.92 092 92 057 0.57 57 0.9 09 9 05 0.5 5 0.

RESUMO JUSTIFICATIVA E OBJETIVOS: Características particulares da dor, como interferência da dor, sintomas do tipo neuropático e sintomas de sensibilização central (SC), podem estar presentes em pacientes com febre Chicungunha e levar a limitações funcionais. O presente estudo teve como objetivo avaliar a correlação entre as características da dor e a capacidade funcional em participantes acometidos pela febre Chicungunha na fase crônica. MÉTODOS: Foi realizado um estudo transversal com 36 participantes que preencheram questionários sociodemográficos, de características de dor (interferência da dor - Inventário Breve de Dor, sintomas do tipo neuropático - questionário PainDETECT, e sinais e sintomas relacionados à SC - Inventário de Sensibilização Central) e de capacidade funcional (Health Assessment Questionnaire). O teste de correlação de Spearman (rho) verificou a relação entre os desfechos. RESULTADOS: A maioria dos participantes era do sexo feminino (77%), com média de idade de 43 anos. Vinte e sete (75%) participantes apresentaram dor nociceptiva e 11 (30%) apresentaram sintomas de sensibilização central. Houve alta correlação positiva entre a presença de sintomas do tipo neuropático e capacidade funcional (rho=0,71; p<0,001) e intensidade da dor e capacidade funcional (rho=0,76; p<0,001). Foi encontrada uma correlação positiva moderada entre os sintomas de sensibilização central e a capacidade funcional (rho=0,51; p=0,002). Além disso, há uma correlação positiva baixa entre a interferência da dor na vida do indivíduo e a capacidade funcional (rho=0,34; p=0,041). CONCLUSÃO: Pacientes em fase crônica da febre Chicungunha apresentaram intensidade de dor leve e predominância de dor nociceptiva. A interferência da dor, os sintomas do tipo neuropático e os sintomas de sensibilização central afetam negativamente a capacidade funcional do indivíduo após a febre Chicungunha. OBJETIVOS SC, , (SC) funcionais MÉTODOS 3 sociodemográficos Dor PainDETECT Central Health Questionnaire. Questionnaire . Questionnaire) rho (rho desfechos RESULTADOS 77%, 77 77% (77%) 4 anos 75% 75 (75% 1 30% 30 (30% rho=0,71 rho071 0 71 (rho=0,71 p<0,001 p0001 p 001 rho=0,76 rho076 76 (rho=0,76 p<0,001. rho=0,51 rho051 51 (rho=0,51 p=0,002. p0002 p=0,002 002 p=0,002) disso rho=0,34 rho034 34 (rho=0,34 p=0,041. p0041 p=0,041 041 p=0,041) CONCLUSÃO (SC 7 (77% (75 (30 rho=0,7 rho07 (rho=0,7 p<0,00 p000 00 rho=0,5 rho05 5 (rho=0,5 p=0,00 rho=0,3 rho03 (rho=0,3 p004 p=0,04 04 (77 (7 (3 rho=0, rho0 (rho=0, p<0,0 p00 p=0,0 ( rho=0 (rho=0 p<0, p0 p=0, rho= (rho= p<0 p=0 p< p=

ABSTRACT BACKGROUND AND OBJECTIVES: Particular pain features, such as pain interference, neuropathic-like symptoms, and central sensitization (CS) symptoms may be present in patients with Chikungunya fever and lead to functional limitations. The present study aimed to assess the association between pain characteristics and the disability in participants affected by Chikungunya fever in the chronic phase. METHODS: A cross-sectional study was conducted with 36 participants who filled out a sociodemographic, pain characteristics (pain interference - Brief Pain Inventory, neuropathic-like symptoms - PainDETECT Questionnaire, and CS-related signs and symptoms - Central Sensitization Inventory) and disability (Health Assessment Questionnaire) questionnaires. The Spearman correlation test (rho) verified the relationship between the outcomes. RESULTS: Most of the participants were female (77%), with a mean age of 43 years. Twenty-seven (75%) participants presented nociceptive pain and 11 (30%) had central sensitization symptoms. There was a high positive correlation between the presence of neuropathic-like symptoms and disability (rho=0.71; p<0.001) and pain intensity and disability (rho=0.76; p<0.001). A moderate positive correlation was found between the central sensitization symptoms and disability (rho=0.51; p=0.002). Moreover, there is a low positive correlation between pain interference in an individual’s life and disability (rho=0.34; p=0.041). CONCLUSION: Patients in chronic phase of Chikungunya fever revealed mild pain intensity and predominance of nociceptive pain. Pain interference, neuropathic-like symptoms, and central sensitization symptoms negatively impact individual’s disability after Chikungunya fever. OBJECTIVES features neuropathiclike neuropathic like CS (CS limitations METHODS crosssectional cross sectional 3 sociodemographic Inventory Questionnaire CSrelated related Health questionnaires rho (rho outcomes RESULTS 77%, 77 77% , (77%) 4 years Twentyseven Twenty seven 75% 75 (75% 1 30% 30 (30% rho=0.71 rho071 0 71 (rho=0.71 p<0.001 p0001 p 001 rho=0.76 rho076 76 (rho=0.76 p<0.001. . rho=0.51 rho051 51 (rho=0.51 p=0.002. p0002 p=0.002 002 p=0.002) Moreover individuals individual s rho=0.34 rho034 34 (rho=0.34 p=0.041. p0041 p=0.041 041 p=0.041) CONCLUSION 7 (77% (75 (30 rho=0.7 rho07 (rho=0.7 p<0.00 p000 00 rho=0.5 rho05 5 (rho=0.5 p=0.00 rho=0.3 rho03 (rho=0.3 p004 p=0.04 04 (77 (7 (3 rho=0. rho0 (rho=0. p<0.0 p00 p=0.0 ( rho=0 (rho=0 p<0. p0 p=0. rho= (rho= p<0 p=0 p< p=

RESUMO JUSTIFICATIVA E OBJETIVOS: A identificação dos locais de dor é um aspecto essencial no manejo de pacientes com Dor Espalhada. Vários instrumentos foram desenvolvidos, incluindo desenhos de dor, um sistema de grade e métodos computadorizados. No entanto, ainda não se sabe se o Índice de Dor Espalhada coincide com um método automatizado (painMAP) para quantificar o número de áreas de dor. Portanto, este estudo teve como objetivo identificar a relação entre o Índice de Dor Espalhada e o painMAP para medir as áreas doloridas em participantes com esse quadro de dor. MÉTODOS: Uma análise secundária pré-planejada de dados coletados de 311 pacientes com dor musculoesquelética foi realizada. O Índice de Dor Espalhada e o painMAP avaliaram as áreas de dor. O coeficiente de correlação de Spearman foi utilizado para investigar a correlação entre o Índice de Dor Espalhada e o software painMAP. RESULTADOS: Um total de 98 participantes com Dor Espalhada foram incluídos neste estudo. A maioria dos participantes era do sexo feminino (67;83,7%), com média de idade de 57,7±11,5 anos, média de altura de 1,6 (0,1) metros e média de peso de 73,2 (11,8) quilogramas. A média de intensidade da dor foi de 6,7 (2,0) e da duração da dor de 92,3 (96,3) meses. O número médio de áreas de dor no Índice de Dor Espalhada foi de 10,1(3,7) e no software painMAP foi de 11,7 (8,8). Uma correlação positiva fraca (rho=0,26, IC de 95% 0,45-0,04, p=0,022) entre o Índice de Dor Espalhada e o painMAP foi encontrada. CONCLUSÃO: O Índice de Dor Espalhada e o painMAP mostraram correlação positiva fraca para avaliar as áreas de dor em participantes com dor espalhada. OBJETIVOS desenvolvidos computadorizados entanto (painMAP Portanto MÉTODOS préplanejada pré planejada 31 realizada RESULTADOS 9 6783,7%, 67837 67 83,7% , 83 7 (67;83,7%) 577115 57 11 5 57,7±11, anos 16 1 6 1, 0,1 01 0 (0,1 732 73 2 73, 11,8 118 8 (11,8 quilogramas 6, 2,0 20 (2,0 923 92 3 92, 96,3 963 96 (96,3 meses 10,13,7 10137 10,1 3,7 10 10,1(3,7 117 11, 8,8. 88 8,8 . (8,8) rho=0,26, rho026 rho 26 (rho=0,26 95 0,450,04, 045004 0,45 0,04, 45 04 0,45-0,04 p=0,022 p0022 p 022 encontrada CONCLUSÃO espalhada 6783 6783,7% 837 83,7 (67;83,7% 57711 57,7±11 0, (0, (11, 2, (2, 96, (96, 13 10,13, 1013 101 10, 37 3, 10,1(3, 8, (8,8 rho=0,26 rho02 (rho=0,2 450 0,450,04 04500 045 0,4 004 0,04 4 0,45-0,0 p=0,02 p002 02 678 6783,7 83, (67;83,7 5771 57,7±1 (0 (11 (2 (96 10,13 10,1(3 (8, rho=0,2 rho0 (rho=0, 0,450,0 0450 00 0,0 0,45-0, p=0,0 p00 6783, (67;83, 577 57,7± ( (1 (9 10,1( (8 rho=0, (rho=0 0,450, 0,45-0 p=0, p0 (67;83 57,7 rho=0 (rho= 0,450 0,45- p=0 (67;8 57, rho= (rho p= (67; (67 (6

ABSTRACT BACKGROUND AND OBJECTIVES: Identifying pain sites is essential to managing patients with Widespread Pain. Several instruments have been developed, including pain drawings, a grid system and computerized methods. However, it is not yet known whether the Widespread Pain Index matches an automated method (painMAP) for quantifying the number of pain areas. Therefore, this study aimed to identify the relationship between the Widespread Pain Index and the painMAP software to measure pain sites in participants with Widespread Pain. METHODS: A pre-planned secondary analysis of data collected from 311 patients with musculoskeletal pain was conducted. The Widespread Pain Index and the painMAP software assessed pain sites. Spearman’s correlation coefficient investigated the correlation between the Widespread Pain Index and the painMAP software. RESULTS: A total of 98 participants with Widespread Pain were included in this study. Most participants were female (67; 83.7%), with a mean age of 57,7±11,5 years, mean height of 1.6 (0.1) meters and mean weight of 73.2 (11.8) kilograms. The mean pain intensity was 6.7 (2.0), and the pain duration was 92.3 (96.3) months. The mean number of pain sites in the Widespread Pain Index was 10.1 (3.7), and in the painMAP software, it was 11.7 (8.8). A weak positive correlation (rho = 0.26, 95% CI 0.45 to 0.04, p = 0.022) between the Widespread Pain Index and the painMAP software was found. CONCLUSION: The Widespread Pain Index and the painMAP software showed a weak correlation for assessing pain sites in participants with Widespread Pain. OBJECTIVES developed drawings methods However (painMAP areas Therefore METHODS preplanned pre planned 31 conducted Spearmans Spearman s RESULTS 9 67 (67 83.7%, 837 83.7% , 83 7 83.7%) 577115 57 11 5 57,7±11, years 16 1 6 1. 0.1 01 0 (0.1 732 73 2 73. 11.8 118 8 (11.8 kilograms 6. 2.0, 20 2.0 (2.0) 923 92 3 92. 96.3 963 96 (96.3 months 101 10 10. 3.7, 37 3.7 (3.7) 117 11. 8.8. 88 8.8 . (8.8) rho 026 26 0.26 95 045 45 0.4 004 04 0.04 0.022 0022 022 found CONCLUSION (6 83.7 57711 57,7±11 0. (0. (11. 2. (2.0 96. (96. 3. (3.7 8. (8.8 02 0.2 4 00 0.0 0.02 002 ( 83. 5771 57,7±1 (0 (11 (2. (96 (3. (8. 577 57,7± (1 (2 (9 (3 (8 57,7 57,

Resumo A corrosão do aço é a principal causa de degradação do concreto estrutural, implicando elevados custos com reabilitação e reparos. Diante disto, barras de FRP – Polímeros Reforçados por Fibras – constituem uma alternativa ao aço convencional em virtude de sua excelente resistência à corrosão. Este trabalho descreve o desenvolvimento de um programa para dimensionamento da armadura de FRP à flexão em vigas de seção T. As diferentes possibilidades referentes à posição da linha neutra, modo de falha e comportamento linear ou não-linear do concreto definem os cenários de dimensionamento para os quais se aplicam as formulações desenvolvidas. Os momentos resistentes calculados apresentaram concordância com valores obtidos experimentalmente, validando a metodologia proposta. Uma vez que as barras de FRP são suscetíveis à ruptura por fluência, tensões devido a cargas permanentes devem se manter inferiores ao limite estabelecido pelo ACI 440.1R-15, ajustando-se as áreas de armadura quando necessário. Desta maneira, foram implementadas no programa, as equações para cálculo da linha neutra e momento resistente baseadas nas áreas ajustadas. Subsequentemente, são apresentados exemplos de dimensionamento considerando os diversos cenários para os quais desenvolveram-se as formulações, combinando-se diferentes tipos de FRP a variadas classes de concreto. Os resultados mostraram que vigas T armadas com FRP de aramida e vidro exigiram elevadas áreas de armadura para atender ao estado limite de ruptura por fluência. Em contrapartida, seções armadas com FRP de carbono exigiram áreas menores, porém exibindo ruptura frágil e curvaturas reduzidas quando sub-armadas.

Abstract The corrosion of steel rebars is the main cause of reinforced concrete degradation, which results in increasing costs with structural rehabilitation and repairs. As a solution, corrosion resistant rebars, such as those of FRP – Fiber-reinforced polymer –, have been used to replace conventional steel. This paper describes the development of a design program that calculates the flexural FRP reinforcement of T-shape beams. The possibilities as regards the neutral axis position, failure mode and concrete linear or non-linear behavior define the design scenarios for which their respective equations were deduced. The flexural strengths computed using the deduced equations showed agreement with experimental results for 125 beams, validating the proposed methodology. Since FRP rebars are vulnerable to creep rupture, the sustained stresses must be lower than the maximum allowed by ACI 440.1R-15, which may require increases in areas, modifying the flexural strength. Therefore, the equations to compute the new neutral axis depth and flexural strength based on the adjusted area were deduced and implemented in the computational program. Subsequently, this paper presents design examples considering all scenarios for which the equations were deduced. The design of one T-section considering different FRP rebars combined to normal and high-performance concretes is also reported. The results showed that beams reinforced with aramid and glass FRP required large areas to avoid creep rupture, whereas the areas of those reinforced by carbon FRP rebars were considerably small; however, they exhibited small curvatures and fragile failure when under-reinforced.

ABSTRACT Objective: To define the mathematical relationship between fructosamine levels and average glucose values. Subjects and methods: The study comprised laboratory data of 1,227 patients with type 1 or 2 diabetes mellitus. Fructosamine levels measured at the end of a 3-week period were compared against the average blood glucose levels of the previous 3 weeks. Average glucose levels were determined by the weighted average of the daily fasting capillary glucose results performed during the study period, and the plasma glucose measured in the same sample collected for fructosamine measurement. Results: In total, 9,450 glucose measurements were performed. Linear regression analysis between fructosamine levels and average glucose levels showed that for each 1.0 µmol/L increase in fructosamine level there was a 0.5 mg/dL increase in average glucose level, as estimated by the equation Mean glucose level = (0.5157 x Fructosamine) – 20. The coefficient of determination (r2 = 0.353492, p < 0.006881) allowed the calculation of the estimated average glucose based on fructosamine level. Conclusion: Our study demonstrated a linear correlation between fructosamine level and mean blood glucose level, suggesting that fructosamine levels can be a proxy for the average glucose level in assessing the metabolic control of patients with diabetes. Objective values methods 1227 227 1,22 mellitus 3week week weeks measurement Results total 9450 9 450 9,45 10 0 1. µmolL µmol L 05 5 0. mgdL mg dL 0.5157 05157 5157 (0.515 20 r2 r (r 0353492 353492 0.353492 0.006881 0006881 006881 Conclusion 122 22 1,2 945 45 9,4 0.515 0515 515 (0.51 035349 35349 0.35349 0.00688 000688 00688 12 1, 94 4 9, 0.51 051 51 (0.5 03534 3534 0.3534 0.0068 00068 0068 (0. 0353 353 0.353 0.006 0006 006 (0 035 35 0.35 0.00 000 00 ( 03 0.3 0.0

Resumo: A abordagem ágil é focada nos indivíduos e na satisfação do cliente, fundamentada no trabalho dinâmico e simplificado de uma equipe capaz de se adaptar e adequar o projeto às mudanças de cenários e de demandas. Contudo, em meio à pandemia da COVID-19, equipes ágeis habituadas à comunicação face a face se depararam com a implantação do home office. O objetivo central desta pesquisa é analisar os desafios gerados pelo contexto de pandemia e do consequente distanciamento social para o desenvolvimento de projetos de software que aplicam as abordagens ágeis em uma empresa estatal de grande porte e os impactos identificados no decorrer e nos resultados dos projetos. A pesquisa teve cunho qualitativo e ocorreu a partir de duas etapas diagnósticas exploratórias. Os achados mostram que não houve impactos negativos de relevância nas entregas do projeto. Indicaram por um lado perdas na socialização, nas trocas espontâneas de conhecimento e na interação entre equipes, assim como exigência de um maior engajamento dos profissionais. Além disso, foram reveladas limitações para discussões mais complexas e na gestão do conhecimento. O estudo aponta soluções encontradas e/ou sugeridas para alguns problemas, contribuindo para a literatura de melhores práticas para a abordagem ágil, com um recorte em um contexto inédito da pandemia da COVID-19 e pode contribuir para outras empresas com perfil similar que atuem com projetos com abordagem ágil, além de contribuir para a construção de diálogo entre os ambientes acadêmico e empresarial. Resumo cliente demandas Contudo COVID19, COVID19 COVID 19, 19 office exploratórias socialização profissionais disso eou ou problemas COVID-1 empresarial COVID1 1 COVID-

Abstract: The Agile approach is focused on individuals and customer satisfaction, based on the dynamic and streamlined work of a team that is capable of adapting, and adapting the project to changing scenarios and demands. However, amidst the COVID-19 pandemic, Agile teams accustomed to in-person communication have encountered the challenges of working from home. The main objective of this research is to analyze the challenges generated by the pandemic context, and the consequent social distance, for the development of software projects that use Agile approaches within a large state-owned company and identify the effect it had on the course and results of the projects. The research was qualitative in nature and had two exploratory diagnostic stages. The findings indicate that there were no negative impacts of relevance on project deliveries. On the one hand, results indicated losses in socialization, in spontaneous exchanges of knowledge, and in interaction among teams, as well as a demand for greater engagement of professionals. Additionally, limitations were revealed for more complex discussions and knowledge management. The study highlights solutions that were found and/or suggested for many challenges, contributing to the literature on best practices for the Agile approach, and is focused on the unprecedented context of the COVID-19 pandemic. Our findings can contribute to other companies with a similar profile that work with Agile projects, besides contributing to building a dialogue between the academic and business environments. Abstract satisfaction demands However COVID19 COVID 19 COVID-1 inperson person home distance stateowned state owned stages deliveries hand socialization professionals Additionally management andor or environments COVID1 1 COVID-

Abstract Background There is little information on how different soil cover systems influence the residual effect of pre-emergent herbicides used in soybean cultivation in Brazil. Objective The objective was to compare the persistence of different pre-emergent herbicides in a Latosolic Dystrophic Red Nitosol soil in the presence or absence of black oat straw on the soil surface. Methods The herbicides used were chlorimuron-ethyl (40.0 g ai ha-1), diclosulam (70.1 g ai ha-1), flumioxazin (100.0 ai g ha-1) and saflufenacil (70.0 g ai ha-1). Soil samples were collected at 0, 5, 10, 15, 20, 32, 46 and 60 days after herbicide application. The bioavailability of the herbicides was evaluated in a greenhouse using cucumber plants as bioindicators. Results Rainfall was necessary for the herbicides to go through the straw layer and reach the soil. Using straw, the half-life times for chlorimuron, diclosulam, flumioxazin and saflufenacil were 42, 61, 49 and 26 days, while without straw, they were 23, 45, 8 and 10 days, respectively. Conclusion The presence of straw on the soil surface increased the persistence of herbicides in the soil. preemergent pre emergent Brazil chlorimuronethyl chlorimuron ethyl 40.0 400 40 0 (40. ha1, ha1 ha 1 , 70.1 701 70 (70. 100.0 1000 100 (100. ha-1 70.0 700 ha1. . 5 15 20 32 4 6 application bioindicators halflife half life 42 61 2 23 45 respectively 40. (40 70. 7 (70 100. (100 ha- 3 (4 (7 (10 ( (1

ABSTRACT Nicotiana azambujae is an endemic species from Santa Catarina state, southern Brazil, that was described in 1964 and has not been seen since then. During fieldwork, we found a population in Alto Matador, about 70 km from the presumable type collection, after 73 years of its last known collection. Thus, we bring the first in vivo pictures of this species, assess its conservation status, update the morphologic description and discuss its habitat preferences. Also, we discuss a possible mistake in the type of voucher label from the originally collected locality. state Brazil 196 then fieldwork Matador 7 collection Thus status preferences Also locality 19 1

Abstract The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region. prevalence clinicopathological (AciCC region 1 countries demographic clinical pathologic followup follow up information 7 included 65.33% 6533 65 33 (65.33% 4551 45 51 45.5 affected 64.28% 6428 64 28 (64.28% 95.66% 9566 95 66 (95.66% 70.68%. 7068 70.68% . 70 68 (70.68%) 48.93% 4893 48 93 (48.93% 86.11%. 8611 86.11% 86 (86.11%) 59.19%. 5919 59.19% 59 19 (59.19%) 20 3043 30 43 30.43% 1250 12 50 12.50% p=0.01, p001 p p=0.01 , 0 01 (p=0.01) highgrade grade p=0.008, p0008 p=0.008 008 (p=0.008) p=0.007, p0007 p=0.007 007 (p=0.007) p=0.03 p003 03 (p=0.03 survival conclusion 65.33 653 6 3 (65.33 455 4 5 45. 64.28 642 2 (64.28 95.66 956 9 (95.66 706 70.68 (70.68% 48.93 489 (48.93 861 86.11 8 (86.11% 591 59.19 (59.19% 304 30.43 125 12.50 p00 p=0.0 (p=0.01 p000 p=0.00 00 (p=0.008 (p=0.007 (p=0.0 65.3 (65.3 64.2 (64.2 95.6 (95.6 70.6 (70.68 48.9 (48.9 86.1 (86.11 59.1 (59.19 30.4 12.5 p0 p=0. (p=0.00 (p=0. 65. (65. 64. (64. 95. (95. 70. (70.6 48. (48. 86. (86.1 59. (59.1 30. 12. p=0 (p=0 (65 (64 (95 (70. (48 (86. (59. p= (p= (6 (9 (70 (4 (86 (59 (p ( (7 (8 (5

RESUMO JUSTIFICATIVA E OBJETIVOS Fibromialgia e dor generalizada representam um problema de saúde global e são distúrbios musculoesqueléticos distintos, mas há uma sobreposição na apresentação clínica entre essas condições. Entretanto, nenhum estudo comparou as características da dor entre os pacientes com estas condições. Portanto, o presente estudo teve como objetivo comparar as características da dor e a limitação funcional de pacientes com fibromialgia e dor generalizada. MÉTODOS Realizou-se uma análise secundária pré-planejada de dados coletados de 311 pacientes com dor musculoesquelética. As características da dor incluíram: intensidade da dor, duração da dor, área da dor, sintomas de sensibilização central, presença de sintomas neuropáticos e a modulação condicionada da dor. A escala de funcionalidade específica do paciente avaliou a limitação funcional. RESULTADOS Identificou-se 98 pacientes com dor generalizada, sendo 58 (59,18%) classificados no grupo de fibromialgia e 40 (40,82%) no grupo de dor generalizada. Diferenças significativas foram encontradas entre os grupos para o índice de dor generalizada, escala de severidade de sintomas e escala polissintomática de sofrimento. Os participantes com fibromialgia apresentaram maiores valores de intensidade da dor (fibromialgia = 7,29±2,07, dor generalizada = 6,05 ± 2,47; p=0,008), sintomas neuropáticos (fibromialgia = 17,74±7,62, dor generalizada = 12,17 ± 6,41; p=0,005) e sintomas de sensibilização central (fibromialgia = 51,32±14,26, dor generalizada = 33,97±14,65; p<0,001), quando comparados à dor generalizada. Não houve diferença significativa na modulação condicionada da dor e na limitação funcional entre os grupos. CONCLUSÃO Pacientes com fibromialgia exibiram características de dor desfavoráveis, incluindo intensidade de dor, sintomas neuropáticos e sintomas de sensibilização central, quando comparados a pacientes com dor generalizada. Entretanto, a duração da dor, a limitação funcional e a modulação condicionada da dor não apresentaram diferença significativa entre os grupos.

ABSTRACT BACKGROUND AND OBJECTIVES Fibromyalgia and generalized pain represent a global health problem and are distinct musculoskeletal disorders, but there is an overlap in the clinical presentation between these conditions. However, no study has compared pain characteristics between patients with fibromyalgia and patients with generalized pain. Therefore, the present study aimed to compare pain characteristics and functional limitation of patients with fibromyalgia and patients with generalized pain. METHODS A pre-planned secondary analysis of data collected from 311 patients with musculoskeletal pain was performed. Pain characteristics included pain intensity, pain duration, pain area, symptoms of central sensitization, presence of neuropathic-like symptoms, and the conditioned pain modulation. The Patient-Specific Functional Scale assessed functional limitation. RESULTS 98 patients with generalized pain were identified, being 58 (59.18%) classified in the fibromyalgia group and 40 (40.82%) classified in the generalized pain group. Significant differences were found between groups for Widespread Pain Index, Symptom Severity Scale, and Polysymptomatic Distress Scale. Participants with fibromyalgia presented higher values of pain intensity (fibromyalgia = 7.29±2.07, generalized pain = 6.05±2.47; p=0.008), neuropathic-like symptoms (fibromyalgia = 17.74±7.62, generalized pain = 12.17±6.41; p=0.005), and symptoms of central sensitization (fibromyalgia = 51.32±14.26, generalized pain = 33.97±14.65; p<0.001), when compared with generalized pain. There was no significant difference in conditioned pain modulation and functional limitation between groups. CONCLUSION Patients with fibromyalgia exhibited unfavorable pain characteristics, including pain intensity, neuropathic-like symptoms, and symptoms of central sensitization compared to patients with generalized pain. However, pain duration, functional limitation, and conditioned pain modulation did not present meaningful differences between groups.

Abstract Territorial governance processes in the Vale dos Vinhedos wine region, Rio Grande do Sul, Brazil, has been characterized by the generation of collaborative networks of wine companies, government agencies, as well as producer associations. That is why this article aims to identify the way in which governance processes have influenced the development of wine and tourism in this oenological region. In this sense, it is highlighted that the oenological agroindustries have ensured that the wine production chain, from production to marketing, are distinguished by the quality and certification of their processes. These characteristics have led to the consolidation of a production where a variety of products and services stand out, promoting valorization strategies, where the presence of products with Denomination of Origin (DO) has allowed this wine-growing area to position itself as one of the most important of America.

Resumen Los procesos de gobernanza territorial en la región vitivinícola de Vale dos Vinhedos, Rio Grande del Sur, Brasil, ha estado caracterizada por la generación de redes colaborativas de las empresas vitivínícolas y dependencias gubernamentales, así como asociaciones de productores. Es por ello que el presente artículo tiene como objetivo identificar la manera en que los procesos de gobernanza han influido en el desarrollo vitivinícola y turístico de esta zona productora. En este sentido, se destaca que las agroindustrias enológicas han procurado que la cadena productiva del vino, desde la producción hasta la comercialización, sean distinguidas por la calidad y certificación de sus procesos. Tales características han llevado a consolidar una producción en la cual reluce una variedad de productos y servicios, fomentando estrategias de valorización, donde la presencia de productos con Denominación de Origen (DO) ha permitido que esta zona vitivinícola se posicione como una de las más importantes de América.

Abstract Background and objectives: Neuropathic pain is common in the general population worldwide and Brazil. The painDETECT questionnaire is a notable instrument for screening on neuropathic pain. A Brazilian version of the painDETECT is necessary to broaden the possibilities of identification of neuropathic pain in the Brazilian population for the proper diagnosis and treatment. The current study aimed to perform the translation and cross-cultural adaptation of the painDETECT into the Portuguese language of Brazil. Methods: A cross-cultural adaptation study was conducted in 11 stages according to standard procedures. Descriptive statistics were performed. The internal consistency of the questionnaire was assessed using Cronbach’s Alpha test (α). Results: Four translators, 10 experts, and 30 patients participated in the study. The expert committee adapted five out of nine items (item 2, 3, 6, 8, and 10) to the Brazilian context. The pretesting phase showed good internal consistency (α = 0.74) for the nine items, including the pain pattern and the body chart domains. The Cronbach’s α of the instrument with seven descriptor items of pain was 0.83. Conclusions: The painDETECT was cross-culturally adapted into a Brazilian context and can be used to identify neuropathic components in pain of Brazilian patients. Clinical implications: PainDETECT is available for Brazilians to identify neuropathic components in pain.