This study aimed to develop and evaluate chitosan (CS) and chitosan with N-Acetyl-D-glucosamine (CS/GlcNAc) sutures, comparing them to commercial Catgut sutures. Medium molecular weight chitosan was processed into sutures using the wet-spinning method, both with and without the addition of GlcNAc. The mechanical properties, surface morphology, biocompatibility, biodegradability and in vivo response of the sutures were evaluated. Scanning electron microscopy (SEM) and enzymatic degradation tests in phosphate-buffered saline (PBS) with lysozyme were conducted. Cytotoxicity was assessed using an agar diffusion assay on L929 cells. In vivo studies involved suturing rat skin, with monitoring at 5, 15 and 25 days post-surgery. Both macroscopic and microscopic analyses were performed to evaluate wound healing, tissue response, and complications. The chitosan-based sutures exhibited tensile strength within the standards for surgical sutures under dry and hydrated conditions. Particularly, the CS/GlcNAc sutures exhibited superior biodegradability, and biocompatibility compared to Catgut sutures. These sutures promoted tissue healing, reduced adverse tissue reactions and infections, and displayed non-toxic to L929 cells and favorable microbiological characteristics. Thus, CS and CS/GlcNAc sutures present promising alternatives to traditional Catgut sutures, contributing valuable advancements to the field of biodegradable surgical materials. (CS NAcetylDglucosamine N Acetyl D glucosamine CSGlcNAc GlcNAc (CS/GlcNAc wetspinning wet spinning method properties morphology evaluated SEM (SEM phosphatebuffered phosphate buffered PBS (PBS conducted L L92 skin 5 1 2 postsurgery. postsurgery post surgery. surgery post-surgery healing complications chitosanbased based conditions Particularly infections nontoxic non toxic characteristics Thus materials L9

ABSTRACT OBJECTIVE To describe the most-cited articles in public health scientific journals edited in Brazil. METHODS Articles published between 2008 and 2010 by public health journals edited in Brazil and indexed in the Scopus database were included, and citations received up to five years after publication were ranked. We studied a total of 105 articles, as the last seven articles shared the same number of citations and so were given the same rank. RESULTS The most-cited articles received a median of 28 citations, and the distribution ranged from 22 to 95 citations. These articles describe advances in the areas of Epidemiology (74%), Health Policies, Planning and Administration (19%), and Social and Human Sciences in Health (7%). Only half mentioned that they have received funding. About 75% of the articles were written by three or more authors and 90%, by authors affiliated to public institutions such as universities and government organizations. Fifteen individuals were responsible for authoring or coauthoring three or more of the 105 articles studied. The journals Cadernos de Saúde Pública, Revista de Saúde Pública, and Ciência & Saúde Coletiva have published the vast majority of the most-cited articles in the area (94%). CONCLUSIONS In Brazil, the most-cited articles in public health mainly report Epidemiology research, are written by groups of authors and by researchers affiliated to public institutions and are published in journals with a greater impact. Periodical analyses of these data can show potential changes in the characteristics of articles that most attract public health scientists.

ABSTRACT OBJECTIVE To describe the most-cited articles in public health scientific journals edited in Brazil. METHODS Articles published between 2008 and 2010 by public health journals edited in Brazil and indexed in the Scopus database were included, and citations received up to five years after publication were ranked. We studied a total of 105 articles, as the last seven articles shared the same number of citations and so were given the same rank. RESULTS The most-cited articles received a median of 28 citations, and the distribution ranged from 22 to 95 citations. These articles describe advances in the areas of Epidemiology (74%), Health Policies, Planning and Administration (19%), and Social and Human Sciences in Health (7%). Only half mentioned that they have received funding. About 75% of the articles were written by three or more authors and 90%, by authors affiliated to public institutions such as universities and government organizations. Fifteen individuals were responsible for authoring or coauthoring three or more of the 105 articles studied. The journals Cadernos de Saúde Pública, Revista de Saúde Pública, and Ciência & Saúde Coletiva have published the vast majority of the most-cited articles in the area (94%). CONCLUSIONS In Brazil, the most-cited articles in public health mainly report Epidemiology research, are written by groups of authors and by researchers affiliated to public institutions and are published in journals with a greater impact. Periodical analyses of these data can show potential changes in the characteristics of articles that most attract public health scientists.

RESUMO Aqui, descrevemos o percentual de não citação em revistas brasileiras de saúde pública, campo até agora não investigado nacional ou internacionalmente. Analisamos artigos, publicados entre 2008 e 2012, de oito revistas de saúde pública indexadas na base Scopus. O percentual de não citação difere entre as revistas (de 5,7% a 58,1%). Identificamos quatro grupos estatisticamente distintos: História, Ciência, Saúde – Manguinhos (58% de artigos não citados); Physis: Revista de Saúde Coletiva, Interface, e Saúde e Sociedade (32% a 37%); Ciência & Saúde Coletiva e Revista Brasileira de Epidemiologia (16% a 17%); e Cadernos de Saúde Pública e Revista de Saúde Pública (6%). A não citação nos primeiros três anos pós-publicação também varia segundo revista. Quatro revistas mostraram claro declínio da não citação: Cadernos de Saúde Pública, Ciência & Saúde Coletiva, Revista Brasileira de Epidemiologia e Physis. Outras três (Revista de Saúde Pública, Saúde e Sociedade e Interface) apresentaram oscilação na não citação, mas as taxas de 2008 e 2012 são similares, com magnitudes diferentes. Por sua vez, a revista História, Ciência, Saúde – Manguinhos mantém taxas elevadas de não citação. Revistas multidisciplinares atraem mais citação, mas um modelo compreensivo de citações ainda precisa ser formulado e testado.

ABSTRACT Here, we describe the percentage of non-citation in Brazilian public health journals, a field that, until now, had not been investigated nationally or internationally. We analyzed articles, published between 2008 and 2012, of eight public health journals indexed in the scopus database. The percentage of non-citation differs between journals (from 5.7% to 58.1%). We identified four statistically distinct groups: História, Ciência, Saúde – Manguinhos (58% uncited articles); Physis: Revista de Saúde Coletiva, Interface, and Saúde e Sociedade (32% to 37%); Ciência & Saúde Coletiva and Revista Brasileira de Epidemiologia (16% to 17%); and Cadernos de Saúde Pública and Revista de Saúde Pública (6%). The non-citation in the first three years post-publication also varies according to journal. Four journals have shown a clear decline of non-citation: Cadernos de Saúde Pública, Ciência & Saúde Coletiva, Revista Brasileira de Epidemiologia, and Physis. Another three (Revista de Saúde Pública, Saúde e Sociedade, and Interface) presented an oscillation in non-citation, but the rates of 2008 and 2012 are similar, with different magnitudes. In turn, the journal História, Ciência, Saúde – Manguinhos maintains high rates of non-citation. Multidisciplinary journals attract more citation, but a comprehensive citation model still needs to be formulated and tested.

RESUMO Aqui, descrevemos o percentual de não citação em revistas brasileiras de saúde pública, campo até agora não investigado nacional ou internacionalmente. Analisamos artigos, publicados entre 2008 e 2012, de oito revistas de saúde pública indexadas na base Scopus. O percentual de não citação difere entre as revistas (de 5,7% a 58,1%). Identificamos quatro grupos estatisticamente distintos: História, Ciência, Saúde – Manguinhos (58% de artigos não citados); Physis: Revista de Saúde Coletiva, Interface, e Saúde e Sociedade (32% a 37%); Ciência & Saúde Coletiva e Revista Brasileira de Epidemiologia (16% a 17%); e Cadernos de Saúde Pública e Revista de Saúde Pública (6%). A não citação nos primeiros três anos pós-publicação também varia segundo revista. Quatro revistas mostraram claro declínio da não citação: Cadernos de Saúde Pública, Ciência & Saúde Coletiva, Revista Brasileira de Epidemiologia e Physis. Outras três (Revista de Saúde Pública, Saúde e Sociedade e Interface) apresentaram oscilação na não citação, mas as taxas de 2008 e 2012 são similares, com magnitudes diferentes. Por sua vez, a revista História, Ciência, Saúde – Manguinhos mantém taxas elevadas de não citação. Revistas multidisciplinares atraem mais citação, mas um modelo compreensivo de citações ainda precisa ser formulado e testado.

ABSTRACT Here, we describe the percentage of non-citation in Brazilian public health journals, a field that, until now, had not been investigated nationally or internationally. We analyzed articles, published between 2008 and 2012, of eight public health journals indexed in the scopus database. The percentage of non-citation differs between journals (from 5.7% to 58.1%). We identified four statistically distinct groups: História, Ciência, Saúde – Manguinhos (58% uncited articles); Physis: Revista de Saúde Coletiva, Interface, and Saúde e Sociedade (32% to 37%); Ciência & Saúde Coletiva and Revista Brasileira de Epidemiologia (16% to 17%); and Cadernos de Saúde Pública and Revista de Saúde Pública (6%). The non-citation in the first three years post-publication also varies according to journal. Four journals have shown a clear decline of non-citation: Cadernos de Saúde Pública, Ciência & Saúde Coletiva, Revista Brasileira de Epidemiologia, and Physis. Another three (Revista de Saúde Pública, Saúde e Sociedade, and Interface) presented an oscillation in non-citation, but the rates of 2008 and 2012 are similar, with different magnitudes. In turn, the journal História, Ciência, Saúde – Manguinhos maintains high rates of non-citation. Multidisciplinary journals attract more citation, but a comprehensive citation model still needs to be formulated and tested.

Introdução: A asma é uma doença inflamatória crónica de alta prevalência, considerada um problema de saúde pública e constitui-se como uma das causas de baixo peso e atraso do crescimento. Objectivo: O objectivo do presente artigo foi rever na literatura os efeitos da asma no estado nutricional em crianças. Material e métodos: Foi realizada uma revisão sistemática com busca de artigos nas bases PubMed, SciELO e LILACS. Foram excluídos os artigos de revisão, estudos com adultos ou pesquisas que não avaliassem os efeitos da asma em crianças. Foram incluídos artigos originais em humanos. Resultados: Na revisão sistemática da literatura foram encontrados 839 na base MEDLINE (1997-2008), 62 artigos na base MEDLINE (1966-1996), 47 no LILACS e 16 no SciELO - Brasil, totalizando 964 artigos. Destes, foram seleccionados 17 artigos. Conclusão: Conclui-se que a evidência de que a asma interfere no estado nutricional não pode ser comprovada neste estudo.

Introduction: Asthma is a chronic inflammatory disease of high prevalence, considered a public health problem and is thought to be one cause of low birth weight and growth retardation. Purpose: The purpose of this article was to review in literature the effects of asthma on the nutritional status in children. Material and methods: A systematic review was made by searching for articles in PubMed, SciELO and LILACS databases. Review articles, studies with adults or research that did not evaluate the effects of asthma in children were excluded. Hence original articles in humans were included. Results: In the systematic review we found 901 articles in MEDLINE (1966-1996), 47 in LILACS and SciELO in the 16 - Brazil, totaling 964 articles. Of these, 17 articles were selected. Conclusion: Evidence that asthma interferes in nutritional status can not be proven in this study.