Abstract Objective: To evaluate the effect of high-fidelity simulation of pediatric emergencies compared to case-based discussion on the development of self-confidence, theoretical knowledge, clinical reasoning, communication, attitude, and leadership in undergraduate medical students. Methods: 33 medical students were allocated to two teaching methods: high-fidelity simulation (HFS, n = 18) or case-based discussion (CBD, n = 15). Self-confidence and knowledge tests were applied before and after the interventions and the effect of HFS on both outcomes was estimated with mixed-effect models. An Objective Structured Clinical Examination activity was conducted after the interventions, while two independent raters used specific simulation checklists to assess clinical reasoning, communication, attitude, and leadership. The effect of HFS on these outcomes was estimated with linear and logistic regressions. The effect size was estimated with the Hedge’sg. Results: Both groups had an increase in self-confidence (HFS 59.1 × 93.6, p < 0.001; CDB 50.5 × 88.2, p < 0.001) and knowledge scores over time (HFS 45.1 × 63.2, p = 0.001; CDB 43.5 × 56.7, p-value < 0.01), but no difference was observed between groups (group*time effect in the mixed effect models adjusted for the student ranking) for both tests (p = 0.6565 and p = 0.3331, respectively). The simulation checklist scores of the HFS group were higher than those of the CBD group, with large effect sizes in all domains (Hedges g 1.15 to 2.20). Conclusion: HFS performed better than CBD in developing clinical reasoning, communication, attitude, and leadership in undergraduate medical students in pediatric emergency care, but no significant difference was observed in self-confidence and theoretical knowledge. highfidelity high fidelity casebased case based selfconfidence, selfconfidence self confidence, confidence reasoning communication attitude Methods 3 methods HFS, 18 CBD, (CBD 15. 15 . 15) Selfconfidence Self mixedeffect regressions Hedgesg. Hedgesg Hedge sg. sg Hedge’sg Results 591 59 1 59. 936 93 6 93.6 0.001 0001 0 001 505 50 5 50. 882 88 2 88.2 451 45 45. 632 63 63.2 435 43 43. 567 56 7 56.7 pvalue value 0.01, 0.01 , 01 0.01) group*time grouptime ranking 06565 6565 0.656 03331 3331 0.3331 respectively. respectively respectively) Hedges 115 1.1 2.20. 220 2.20 20 2.20) Conclusion care 9 93. 0.00 000 00 8 88. 4 63. 56. 0.0 0656 656 0.65 0333 333 0.333 11 1. 22 2.2 0. 065 65 0.6 033 0.33 2. 06 03 0.3

Abstract Objective: To evaluate exclusive breastfeeding at discharge and hospital length-of-stay in pre-term infants undergoing or not the Kangaroo-Mother Care Method (KMC). Methods: A retrospective cohort study was conducted including preterm infants < 1800 g admitted to the neonatal unit of a KMC reference center. The infants were grouped into the KMC group and the non-KMC group. Multiple logistic and Poisson regressions were performed to evaluate the association between the KMC and two outcomes, exclusive breastfeeding at discharge, and hospital length-of-stay, adjusted for potential confounders. Results: 115 mother-infant dyads were included, 78 in the KMC group and 37 in the non-KMC group. In the bivariate analysis, the KMC group had a lower prevalence of maternal adverse conditions (6% vs. 32%, p < 0.001), a higher number of prenatal visits (median 6 vs. 3.5, p < 0.001), higher gestational ages (median 32 vs. 31 weeks, p < 0.05), higher birth weights (median 1530 vs. 1365 g, p < 0.01), a lower prevalence of necrotizing enterocolitis (3.8% vs. 16.2%, p < 0.05), parenteral nutrition (50% vs. 73%, p < 0.05), and deep vascular access (49.7% vs. 78.4%, p < 0.01), a higher prevalence of exclusive breastfeeding (65% vs. 8%, p < 0.001) and a shorter length of hospital stay (median 28 vs. 42 days, p < 0.001). In the multiple regression analysis, the KMC group was 23 times more likely to be exclusively breastfed at discharge (OR = 23.1; 95% CI = 4,85–109,93) and had a 19% reduction in the hospital length-of-stay (IDR = 0.81; 95% CI = 0.76–0.86) compared to the non-KMC group. Conclusions: The KMC is associated with better short-term neonatal outcomes and should be encouraged in all Brazilian maternity hospitals. Objective lengthofstay pre term KangarooMother Kangaroo Mother KMC. . (KMC) Methods 180 center nonKMC non lengthofstay, stay, confounders Results 11 motherinfant mother infant included 7 3 analysis 6% (6 vs 32% 0.001, 0001 0.001 , 0 001 median 35 5 3.5 weeks 0.05, 005 0.05 05 0.05) 153 136 0.01, 0.01 01 0.01) 3.8% 38 8 (3.8 162 16 2 16.2% 50% 50 (50 73 73% 49.7% 497 49 (49.7 784 4 78.4% 65% 65 (65 8% days 0.001. OR 23.1 231 1 95 4,85–109,93 48510993 85 109 93 19 IDR 0.81 081 81 0.76–0.86 076086 76 86 Conclusions shortterm short hospitals (KMC 18 ( 000 0.00 00 3. 0.0 15 13 3.8 (3. 16.2 (5 49.7 (49. 78.4 23. 9 4,85–109,9 4851099 10 0.8 08 0.76–0.8 07608 0. (3 16. 49. (49 78. 4,85–109, 485109 0.76–0. 0760 (4 4,85–109 48510 0.76–0 076 4,85–10 4851 0.76– 07 4,85–1 485 0.76 4,85– 48 0.7 4,85 4,8 4,

Abstract This study analyzed the prevalence of complete neonatal screening (CNS) of children aged under 2 years in Brazil and associated factors using data from the 2013 (n=4,442) and 2019 (n=5,643) national health surveys. We conducted a cross-sectional study to compare prevalence of CNS (eye, ear and heel prick tests) adopting 95% confidence intervals (95%CI) and a 5% significance level. Crude and adjusted Poisson regression was performed to estimate prevalence ratios (PR) and 95%CI to assess the association between socioeconomic, demographic and health variables and CNS. There was a statistically significant increase in CNS prevalence, from 49.2% (95%CI: 47.1-51.3) in 2013 to 67.4% (95%CI: 65.5-69.3) in 2019. However, large disparities persist across states and between sociodemographic groups. In both years, CNS prevalence was lowest among brown and black children, those from families in the three lowest income quintiles, children without health insurance, those from families registered in the Family Health Strategy and children living in the North, cities outside the state capital/metropolitan regions and rural areas. Despite the increase in prevalence of CNS, deep individual and contextual inequalities persist, posing challenges for health policies. (CNS 201 n=4,442 n4442 n 4 442 (n=4,442 n=5,643 n5643 5 643 (n=5,643 surveys crosssectional cross sectional eye, eye (eye tests 95 95CI CI (95%CI level PR (PR socioeconomic 492 49 49.2 47.151.3 471513 47.1 51.3 47 1 51 3 47.1-51.3 674 67 67.4 65.569.3 655693 65.5 69.3 65 69 65.5-69.3 However groups quintiles insurance North capitalmetropolitan capital metropolitan areas policies 20 n=4,44 n444 44 (n=4,44 n=5,64 n564 64 (n=5,64 9 49. 151 47.151. 47151 471 47. 513 51. 47.1-51. 6 67. 569 65.569. 65569 655 65. 693 69. 65.5-69. n=4,4 n44 (n=4,4 n=5,6 n56 (n=5,6 15 47.151 4715 47.1-51 56 65.569 6556 65.5-69 n=4, n4 (n=4, n=5, n5 (n=5, 47.15 47.1-5 65.56 65.5-6 n=4 (n=4 n=5 (n=5 47.1- 65.5- n= (n= (n

Resumo Analisou-se a prevalência e fatores associados à realização da Triagem Neonatal Completa (TNC) entre crianças (<2 anos de idade) no Brasil incluídas na Pesquisa Nacional Saúde 2013 (n=4.442) e 2019 (n=5.643). Estudo transversal comparou as estimativas de prevalência e intervalos de confiança de 95% (IC95%) da TNC (testes do olhinho, orelhinha e pezinho). Diferenças foram consideradas estatisticamente significante ao nível de 5%. Regressões de Poisson bruta e ajustada foram realizadas para estimar Razões de Prevalência (RP) e IC95% para a associação das variáveis socioeconômicas, demográficas e de saúde com a TNC. Verificou-se aumento estatisticamente significante da TNC: 67,4% (IC95%: 65,5-69,3) em 2019, ante 49,2% (IC95%: 47,1-51,3) em 2013. Porém, ainda existem desigualdades e defasagens entre os estados da federação e variáveis sociodemográficas. Entre os anos, a TNC foi menor nas crianças de cor/raça parda e preta, dos três piores quintis de renda, sem plano de saúde, cadastradas na Estratégia de Saúde da Família, da região norte, de cidades do interior e da zona rural do Brasil. Apesar de o aumento da prevalência de TNC, desigualdades e defasagens individuais e contextuais permaneceram, indicando os desafios das políticas de saúde. Analisouse Analisou se (TNC <2 2 (< idade 201 n=4.442 n4442 n 4 442 (n=4.442 n=5.643. n5643 n=5.643 . 5 643 (n=5.643) 95 IC95 IC (IC95% testes olhinho pezinho. pezinho pezinho) 5% RP (RP socioeconômicas Verificouse Verificou 674 67 67,4 65,569,3 655693 65,5 69,3 65 69 3 65,5-69,3 492 49 49,2 47,151,3 471513 47,1 51,3 47 1 51 47,1-51,3 Porém sociodemográficas corraça cor raça preta renda Família norte permaneceram < ( 20 n=4.44 n444 44 (n=4.44 n564 n=5.64 64 (n=5.643 9 IC9 (IC95 6 67, 569 65,569, 65569 655 65, 693 69, 65,5-69, 49, 151 47,151, 47151 471 47, 513 51, 47,1-51, n=4.4 n44 (n=4.4 n56 n=5.6 (n=5.64 (IC9 56 65,569 6556 65,5-69 15 47,151 4715 47,1-51 n=4. n4 (n=4. n5 n=5. (n=5.6 (IC 65,56 65,5-6 47,15 47,1-5 n=4 (n=4 n=5 (n=5. 65,5- 47,1- n= (n= (n=5 (n

Resumo Analisou-se a prevalência e fatores associados à realização da Triagem Neonatal Completa (TNC) entre crianças (<2 anos de idade) no Brasil incluídas na Pesquisa Nacional Saúde 2013 (n=4.442) e 2019 (n=5.643). Estudo transversal comparou as estimativas de prevalência e intervalos de confiança de 95% (IC95%) da TNC (testes do olhinho, orelhinha e pezinho). Diferenças foram consideradas estatisticamente significante ao nível de 5%. Regressões de Poisson bruta e ajustada foram realizadas para estimar Razões de Prevalência (RP) e IC95% para a associação das variáveis socioeconômicas, demográficas e de saúde com a TNC. Verificou-se aumento estatisticamente significante da TNC: 67,4% (IC95%: 65,5-69,3) em 2019, ante 49,2% (IC95%: 47,1-51,3) em 2013. Porém, ainda existem desigualdades e defasagens entre os estados da federação e variáveis sociodemográficas. Entre os anos, a TNC foi menor nas crianças de cor/raça parda e preta, dos três piores quintis de renda, sem plano de saúde, cadastradas na Estratégia de Saúde da Família, da região norte, de cidades do interior e da zona rural do Brasil. Apesar de o aumento da prevalência de TNC, desigualdades e defasagens individuais e contextuais permaneceram, indicando os desafios das políticas de saúde.

Abstract This study analyzed the prevalence of complete neonatal screening (CNS) of children aged under 2 years in Brazil and associated factors using data from the 2013 (n=4,442) and 2019 (n=5,643) national health surveys. We conducted a cross-sectional study to compare prevalence of CNS (eye, ear and heel prick tests) adopting 95% confidence intervals (95%CI) and a 5% significance level. Crude and adjusted Poisson regression was performed to estimate prevalence ratios (PR) and 95%CI to assess the association between socioeconomic, demographic and health variables and CNS. There was a statistically significant increase in CNS prevalence, from 49.2% (95%CI: 47.1-51.3) in 2013 to 67.4% (95%CI: 65.5-69.3) in 2019. However, large disparities persist across states and between sociodemographic groups. In both years, CNS prevalence was lowest among brown and black children, those from families in the three lowest income quintiles, children without health insurance, those from families registered in the Family Health Strategy and children living in the North, cities outside the state capital/metropolitan regions and rural areas. Despite the increase in prevalence of CNS, deep individual and contextual inequalities persist, posing challenges for health policies.

Resumen: Este estudio evaluó el reconocimiento (imitación, identidad e identificación) y la denominación de estímulos emocionales negativos (enfado y tristeza) y positivos (alegría y sorpresa) y la influencia de los tipos de estímulos utilizados (social-femenino, social-masculino, familiar y emoji ) de niños y jóvenes con autismo o síndrome de Down, a través de tareas aplicadas por la familia, mediadas por recursos tecnológicos durante la pandemia de la covid-19. Participaron cinco niños y dos adultos jóvenes con autismo, y un niño y dos adultos jóvenes con síndrome de Down. Se planificaron e implementaron tareas de identidad, reconocimiento, nombramiento e imitación con estímulos faciales con función evaluativa (sin consecuencia diferencial) y enseñanza (con consecuencia diferencial, uso de ayudas y criterios de aprendizaje), buscando la emergencia del nombramiento emocional después de la enseñanza de tareas de reconocimiento. Los resultados de la línea de base identificaron que para los participantes que tenían un tiempo de respuesta más corto para el mismo género, la diferencia en el tiempo de respuesta fue un 57,28% menor. En cuanto a la valencia emocional, el 50% de los participantes mostraron diferencias en las respuestas correctas, en función de la valencia positiva y negativa, y el 66,66% tuvieron diferencias en el tiempo de respuesta, en función de la valencia emocional. Después del procedimiento de enseñanza, los participantes mostraron mayor número de aciertos en las tareas evaluadas, independientemente del tipo de estímulo o valencia emocional, lo que genera una oportunidad para la generalización del aprendizaje de reconocimiento y denominación de emociones, además de consolidar la viabilidad de estrategias de enseñanza mediadas por recursos tecnológicos y aplicadas por la familia. Resumen imitación, (imitación identificación enfado tristeza alegría sorpresa socialfemenino, socialfemenino social femenino, femenino (social-femenino socialmasculino, socialmasculino masculino, masculino social-masculino Down familia covid19. covid19 covid 19. 19 covid-19 sin diferencial aprendizaje, , aprendizaje) género 5728 57 28 57,28 menor 50 correctas negativa 6666 66 66,66 evaluadas emociones covid1 1 covid-1 572 5 2 57,2 666 6 66,6 covid- 57, 66,

Abstract: This study evaluated the recognition (imitation, identity, and identification) and naming of negative (anger and sadness) and positive (joy and surprise) emotional stimuli alongside the influence of the types of stimuli (social-female, social-male, family, and emoji) in children and young adults with autism and Down syndrome, via tasks applied by the family and mediated by technological resources, during the COVID-19 pandemic. Five children and two young adults with autism and one child and two young adults with Down syndrome participated. Identity, recognition, naming, and imitation tasks were planned and implemented using facial stimuli with evaluative (without differential consequence) and teaching (with differential consequence, tips, and learning criteria) functions, aiming at the emergence of emotional naming from the recognition teaching tasks. The baseline results showed that, for participants who had a shorter response time for the same gender, the response time difference was on average 57.28% lower. Regarding the emotional valence, 50% of the participants showed differences in the correct answers, depending on the positive and negative valence, and 66.66% showed differences in the response time depending on the emotional valence. After the teaching procedure, the participants showed a greater number of correct answers in the tasks, regardless of the stimulus type and emotional valence, creating an opportunity for generalizing learning of emotion recognition and naming, in addition to consolidating the feasibility of teaching strategies mediated by technological resources and applied by family members. Abstract imitation, (imitation identity identification anger sadness joy surprise socialfemale, socialfemale social female, female (social-female socialmale, socialmale male, male social-male emoji COVID19 COVID 19 COVID-1 pandemic participated Identity without consequence tips criteria functions that gender 5728 57 28 57.28 lower valence 50 6666 66 66.66 procedure members COVID1 1 COVID- 572 5 2 57.2 666 6 66.6 57. 66.

Resumo: Este estudo avaliou o reconhecimento (imitação, identidade e identificação) e a nomeação de estímulos emocionais de valência negativa (raiva e tristeza) e positiva (alegria e surpresa) em conjunto com a influência dos tipos de estímulos utilizados (social-feminino, social-masculino, familiar e emoji) em crianças e jovens adultos com autismo ou síndrome de Down, por meio de tarefas aplicadas pela família e mediadas por recursos tecnológicos durante a pandemia de covid-19. Participaram cinco crianças e dois jovens adultos com autismo e uma criança e dois jovens adultos com síndrome de Down. Foram implementadas tarefas de identidade, reconhecimento, nomeação e imitação, com estímulos faciais de função avaliativa (sem consequência diferencial) e de ensino (com consequência diferencial, uso de dicas e critério de aprendizagem), visando a emergência da nomeação emocional por meio do ensino das tarefas de reconhecimento. Os resultados da linha de base identificaram que, para os participantes que apresentaram menor tempo de resposta para o mesmo gênero, a diferença de tempo de resposta foi em média 57,28% menor. Em relação à valência emocional, 50% dos participantes apresentaram diferenças nos acertos, a depender da valência positiva e negativa, sendo que 66,66% apresentaram diferenças para o tempo de resposta a depender da valência emocional. Após o procedimento de ensino, os participantes mostraram maior número de acertos nas tarefas, independentemente do gênero de estímulo e valência emocional, criando ocasião para generalização da aprendizagem de reconhecimento e nomeação de emoções, além de consolidar a viabilidade de estratégias de ensino mediadas por recursos tecnológicos e aplicadas por familiares. Resumo imitação (imitação identificação raiva tristeza alegria surpresa socialfeminino, socialfeminino social feminino, feminino (social-feminino socialmasculino, socialmasculino masculino, masculino social-masculino emoji Down covid19. covid19 covid 19. 19 covid-19 sem diferencial aprendizagem, , aprendizagem) 5728 57 28 57,28 50 6666 66 66,66 emoções familiares covid1 1 covid-1 572 5 2 57,2 666 6 66,6 covid- 57, 66,

Abstract Introduction: The use of realistic simulation in pediatric emergencies is particularly valuable, as it allows the training of technical, attitudinal, and cognitive skills, helping to ensure patient safety. Objective: This study aims to describe the student’s perception of using the High-Fidelity Realistic Simulation in the pediatric emergency modules during the internship. Methods: Observational, descriptive study with a quantitative and qualitative approach. A semi-structured questionnaire was applied to sixth-year medical students at the end of the pediatric internship modules, which lasted eight weeks, from August to December 2020. All of them participated in two types of activities on 14 topics: high-fidelity simulation (HFS) and structured discussion of clinical cases (SDCC). Results: Of the 33 participants, 29 answered the questionnaire. The mean age was 24 ± 1.8 years, and 58.6% were female. All agreed that the experience with HFS contributed to safer performance in pediatric emergencies, considered optimal by 76% and good for the remainder. Most thought the association of HFS and SDCC was the ideal method (96%). The content analysis of the responses on HFS highlighted thematic units in five categories: significant learning, contribution to professional training, skills, attitude/behavior, and quality of the activity. Conclusions: Students’ reaction to using HFS in pediatric emergencies was very positive, and its association with SDCC was considered the ideal teaching method. Knowing the students’ reactions helps teachers plan their activities to improve the teaching-learning method. Introduction valuable technical attitudinal skills safety Objective student s HighFidelity High Fidelity Methods Observational approach semistructured semi sixthyear sixth year weeks 2020 1 topics highfidelity high fidelity (HFS SDCC. . (SDCC) Results 3 participants 2 18 8 1. years 586 58 6 58.6 female 76 remainder 96%. 96 96% (96%) categories learning attitudebehavior attitude behavior attitude/behavior activity Conclusions Students positive teachinglearning 202 (SDCC 5 58. 7 9 (96% 20 (96 (9 (

Resumo Introdução: O uso de simulação realística em emergências pediátricas é particularmente valioso, pois permite o treinamento de habilidades técnicas, atitudinais e cognitivas, ajudando a garantir a segurança do paciente. Objetivo: Este estudo tem como objetivo descrever a percepção do aluno sobre o uso da Simulação Realista de Alta Fidelidade nos módulos de emergência pediátrica durante o internato de medicina. Métodos: Estudo observacional, descritivo, com abordagem quantitativa e qualitativa. Um questionário semiestruturado foi aplicado aos estudantes do sexto ano de medicina ao final dos módulos de internato pediátrico, com oito semanas de duração, de agosto a dezembro de 2020. Todos participaram de dois tipos de atividades sobre 14 temas: simulação de alta fidelidade (SRAF) e discussão estruturada de casos clínicos (DCC). Resultados: Dos 33 participantes, 29 responderam ao questionário. A média de idade foi de 24 ± 1,8 anos, sendo 58,6% do sexo feminino. Todos concordaram que a experiência com SRAF contribuiu para um desempenho mais seguro em emergências pediátricas, considerado ótimo por 76% e bom para os demais. A maioria achava que a associação de SRAF e DCC era o método ideal (96%). A análise de conteúdo das respostas sobre a SRAF destacou unidades temáticas em cinco categorias: aprendizagem significativa, contribuição para a formação profissional, habilidades, atitude/comportamento e qualidade da atividade. Conclusões: A reação dos estudantes ao uso da SRAF em emergências pediátricas foi muito positiva, e sua associação com a DCC foi considerada o método de ensino ideal. Conhecer as reações dos alunos ajuda os professores a planejarem suas atividades para melhorar o método de ensino-aprendizagem. Introdução valioso técnicas cognitivas paciente Objetivo Métodos observacional descritivo qualitativa pediátrico duração 2020 1 temas (SRAF DCC. . (DCC) Resultados 3 participantes 2 18 8 1, anos 586 58 6 58,6 feminino 76 demais 96%. 96 96% (96%) categorias significativa profissional atitudecomportamento atitude comportamento atividade Conclusões positiva ensinoaprendizagem. ensinoaprendizagem aprendizagem. ensino-aprendizagem 202 (DCC 5 58, 7 9 (96% 20 (96 (9 (

Scaffolds are devices with interconnected pores that favor cell interaction and proliferation. They play a significant role in tissue engineering, as they mimic the conditions of tissue production in vivo. The aim of this study was to synthesize scaffolds of chitosan, collagen, and Jatropha mollissima by lyophilization and characterize their chemical/biodegradability and morphological properties. For that, techniques of optical microscopy, infrared spectrometry, biodegradation test, and degree of swelling were performed. A 2% (m/v) chitosan/collagen (1:9) in lactic acid solution was produced. Then, Jatropha mollissima crude extract was added to this solution in different proportions of mass (5, 10, and 15%). Optical microscope images indicated the three-dimensional network formation with interconnected pores and predominantly lamellar shape. Through infrared spectrometry, characteristic bands indicated a physical mixture. Also, the swelling degree of all samples was proportional to the amount of Jatropha mollissima extract with the highest percentage of 1852%. Biodegradation test also revealed a proportional ratio between the amount of sap used and the degraded percentage with the lowest value of around 35% in 28 days. In conclusion, it can be inferred that the scaffolds produced show potential to be used in tissue engineering as dressings. proliferation vivo chitosan collagen chemicalbiodegradability chemical biodegradability properties microscopy spectrometry performed 2 m/v mv m v (m/v chitosancollagen 19 1 9 (1:9 Then 5, 5 (5 10 15%. 15 15% . 15%) threedimensional three dimensional shape mixture Also 1852 1852% 35 days conclusion dressings (1: ( 185 3 (1 18

ABSTRACT Purpose: to assess the influence of wearing a mask on auditory-visual speech recognition, in a favorable listening situation, in hearing devices users. Methods: a cross-sectional observational study comprising 52 hearing aid users, whose speech recognition was assessed with six video-recorded lists of sentences with and without masks. The mean test results in the various situations were compared using the Friedman test with Bonferroni post hoc, the significance level being set at 5%. Results: speech recognition assessment results differed between the situations with and without masks and between mask types, with a small effect size. The post hoc, with p-values adjusted with the Bonferroni method, showed a difference between transparent masks and others. The transparent one had a higher mean (77.8%) of auditory-visual sentence recognition between the various situations. There were statistically significant differences, as the transparent mask provided a better performance than the others. Conclusion: the auditory-visual recognition of the hearing-impaired people was better with the transparent mask. Purpose auditoryvisual auditory visual situation users Methods crosssectional cross sectional 5 videorecorded video recorded hoc 5% Results types size pvalues p values method others 77.8% 778 77 8 (77.8% differences Conclusion hearingimpaired impaired 77.8 7 (77.8 77. (77. (77 (7 (

RESUMO Objetivo: avaliar a influência do uso de máscara no reconhecimento auditivo-visual de fala, em situação de escuta favorável, em usuários de dispositivos eletrônicos auxiliares à audição (DEAA). Métodos: estudo observacional transversal. Participaram 52 usuários de dispositivos auxiliares à audição que realizaram avaliação do reconhecimento de fala com seis listas de frases apresentadas em vídeo com e sem máscaras. Para comparar as médias dos resultados do teste nas diferentes situações, foi aplicado o Teste de Friedman, com pos-hoc de Bonferroni e nível de significância 5%. Resultados: houve diferença dos resultados da avaliação de reconhecimento de fala entre as diferentes situações, com e sem máscara, assim como entre os tipos de máscara, com tamanho de efeito de pequeno. O post-hoc, com valor de p ajustado pelo método de Bonferroni, mostrou diferença entre a máscara transparente e as demais. A máscara transparente apresentou maior média (77,8%) do reconhecimento auditivo-visual nas sentenças utilizadas entre as situações. Foram observadas diferenças estatisticamente significantes com desempenho superior da máscara transparente em relação aos outros tipos de máscaras. Conclusão: conclui-se que o reconhecimento auditivo-visual para os deficientes auditivos foi melhor com a máscara transparente. Objetivo auditivovisual auditivo visual favorável DEAA. DEAA . (DEAA) Métodos transversal 5 máscaras situações Friedman poshoc pos hoc 5% Resultados pequeno posthoc, posthoc post hoc, post-hoc demais 77,8% 778 77 8 (77,8% Conclusão concluise conclui se (DEAA 77,8 7 (77,8 77, (77, (77 (7 (

Stemodin (1) is a diterpene produced by Stemodia maritima L. (Scrophulariaceae) and shows antiviral and tumor cell proliferation inhibitory activities. Chemical modifications of 1 were performed to produce the known stemodinone (2), two new stemodinone oximes, Z (3) and E (4), and seven new oxime esters derivatives (5, 6, 7, 8, 9, 10, and 11). All derivatives were evaluated for their cytotoxic activity in HL60 (promyelocytic leukemia), SNB-19 (astrocytoma), HCT-116 (colon carcinoma), and PC3 (prostate) human cancer cell lines, and L929 (healthy murine cells). Oximes 3 and 4 showed lower cytotoxic values than 1 against all cancer cell lines tested. However, esters 9 and 10 exhibited cell growth inhibition percentages higher than 1 against PC3, SNB-19, and HCT-116 cancer cell lines, ranging from 62.96 to 94.27%. Many of these values exceed that presented by doxorubicin (66.05-86.87%). All compounds showed no cytotoxic effect on healthy cells at the tested concentration of 25 µg mL-1. (1 L Scrophulariaceae (Scrophulariaceae activities 2, 2 , (2) oximes (3 4, (4) 5, 5 (5 6 7 8 11. 11 . 11) HL HL6 promyelocytic leukemia, leukemia leukemia) SNB19 SNB 19 SNB-1 astrocytoma, astrocytoma (astrocytoma) HCT116 HCT 116 HCT-11 colon carcinoma, carcinoma carcinoma) PC prostate (prostate L92 cells. cells) However SNB19, 19, 6296 62 96 62.9 9427 94 27 94.27% 66.0586.87%. 66058687 66.05 86.87% 66 05 86 87 (66.05-86.87%) mL1. mL1 mL 1. mL-1 ( (2 (4 SNB1 SNB- (astrocytoma HCT11 HCT-1 L9 629 62. 942 94.27 0586 66.0586.87% 6605868 6605 66.0 8687 86.87 0 (66.05-86.87% mL- HCT1 HCT- 94.2 058 66.0586.87 660586 660 66. 868 86.8 (66.05-86.87 94. 66.0586.8 66058 86. (66.05-86.8 66.0586. (66.05-86. 66.0586 (66.05-86 66.058 (66.05-8 (66.05- (66.05 (66.0 (66. (66 (6

ABSTRACT OBJECTIVE To evaluate the evolution of the dietary patterns of adolescents in the northeast region of Brazil. METHODS Secondary analysis of data from the Pesquisa de Orçamentos Familiares (POF – Household Budget Surveys), collected by the Brazilian Institute of Geography and Statistics (IBGE) in the years 2008–2009 and 2017–2018. A total of 3,095 adolescents were evaluated in 2008–2009 and 3,015 in 2017–2018. Food consumption was assessed using two dietary records in 2008–2009 and two 24-hour recalls in 2017–2018, applied on non-consecutive days. Based on these data, principal components factor analysis (PCFA) was performed, followed by orthogonal rotation of the varimax type, to derive dietary patterns, stratified by sex. The results were described as means or percentage frequencies, with their respective 95% confidence intervals. RESULTS Three main dietary patterns were identified among adolescents from the northeast region of Brazil. Among boys, in 2008–2009, the patterns were called snacks, traditional Brazilian, and coffee; and in 2017–2018, traditional Brazilian, snacks, and mixed, in this order of representativeness of the group’s eating habits. Among female adolescents, in 2008–2009, the patterns were snacks, traditional Brazilian, and coffee; and in 2017–2018, traditional Brazilian, snacks, and processed meats. CONCLUSION The dietary patterns identified in 2008–2009 and 2017–2018 were similar in both genders; however, the snacks pattern, which explained most of the data variability in 2008–2009, was replaced by the traditional Brazilian.

ABSTRACT OBJECTIVE To evaluate the evolution of the dietary patterns of adolescents in the northeast region of Brazil. METHODS Secondary analysis of data from the Pesquisa de Orçamentos Familiares (POF – Household Budget Surveys), collected by the Brazilian Institute of Geography and Statistics (IBGE) in the years 2008–2009 and 2017–2018. A total of 3,095 adolescents were evaluated in 2008–2009 and 3,015 in 2017–2018. Food consumption was assessed using two dietary records in 2008–2009 and two 24-hour recalls in 2017–2018, applied on non-consecutive days. Based on these data, principal components factor analysis (PCFA) was performed, followed by orthogonal rotation of the varimax type, to derive dietary patterns, stratified by sex. The results were described as means or percentage frequencies, with their respective 95% confidence intervals. RESULTS Three main dietary patterns were identified among adolescents from the northeast region of Brazil. Among boys, in 2008–2009, the patterns were called snacks, traditional Brazilian, and coffee; and in 2017–2018, traditional Brazilian, snacks, and mixed, in this order of representativeness of the group’s eating habits. Among female adolescents, in 2008–2009, the patterns were snacks, traditional Brazilian, and coffee; and in 2017–2018, traditional Brazilian, snacks, and processed meats. CONCLUSION The dietary patterns identified in 2008–2009 and 2017–2018 were similar in both genders; however, the snacks pattern, which explained most of the data variability in 2008–2009, was replaced by the traditional Brazilian. Brazil POF Surveys, Surveys , Surveys) IBGE (IBGE 20082009 2008 2009 2008–200 20172018 2017 2018 3095 3 095 3,09 3015 015 3,01 24hour hour 24 nonconsecutive non consecutive days PCFA (PCFA performed type sex frequencies 95 intervals boys coffee mixed groups group s habits meats 2017–201 genders however pattern 2008200 200 2008–20 2017201 201 309 09 3,0 301 01 2 9 2017–20 200820 20 2008–2 201720 30 0 3, 2017–2 20082 2008– 20172 2017–

ABSTRACT Objective: To assess the relationship between celiac disease and the prevalence of dental caries in children and adolescents and also evaluate if dental enamel defects in celiac children predispose to dental caries. Material and Methods: Searches were performed in the following databases: PubMed, Scopus, Cochrane Library, Latin American and Caribbean Literature on Health Sciences, and OpenGrey. The risk of bias was assessed using the Newcastle-Ottawa Scale. DMFT/dmft and DMFS/dmfs data of observational studies that compared the prevalence of caries between children and adolescents with celiac disease and healthy individuals. Meta-analysis was performed using a random effects model. Heterogeneity between studies was estimated using Cochran’s Q test, and inconsistency was measured using I2 statistics. Results: Of the 121 studies retrieved, 17 were selected, and 12 were included in the meta-analysis. The prevalence of caries in the primary dentition (dmft) did not differ between celiac patients and controls [SMD = -0.35; 95% CI (-0.83; 0.13); p = 0,15; I2 = 89%]. There was also no difference in the prevalence of caries in permanent teeth (DMFT) between groups [SMD = -0.44; 95% CI (-1.02; 0.14); p = 0.14; I2 = 95%]. Conclusion: Celiac disease is not a determinant factor in the development of dental caries in children and adolescents compared to the control group. Objective Methods databases PubMed Scopus Library Sciences OpenGrey NewcastleOttawa Newcastle Ottawa Scale DMFTdmft DMFT dmft DMFSdmfs DMFS dmfs individuals Metaanalysis Meta analysis model Cochrans Cochran s test I statistics Results retrieved 1 selected metaanalysis. metaanalysis meta analysis. meta-analysis (dmft SMD 0.35 035 0 35 -0.35 95 0.83 083 83 (-0.83 0.13 013 13 0.13) 0,15 015 15 89%. 89 89% . 89%] (DMFT 0.44 044 44 -0.44 1.02 102 02 (-1.02 0.14 014 14 0.14) 95%. 95%] Conclusion group 0.3 03 3 -0.3 9 0.8 08 8 (-0.8 0.1 01 0,1 0.4 04 4 -0.4 1.0 10 (-1.0 0. -0. (-0. 0, 1. (-1. -0 (-0 (-1 - (- (

RESUMEN Objetivos: identificar las prácticas de los profesionales de la salud de Atención Primaria frente a la lepra. Métodos: revisión del alcance, realizada entre noviembre de 2022 y enero de 2023, realizada de acuerdo con el marco metodológico propuesto por JBI y checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews en seis bases de datos y literatura adicional. Resultados: la muestra estuvo compuesta por 11 artículos, publicados entre 2008 y 2022. Los hallazgos se resumieron en tres categorías: Diagnóstico precoz y tratamiento oportuno; Prevención de discapacidades físicas; y Vigilancia de los contactos domésticos y sociales. Consideraciones Finales: es necesario alinear las prácticas realizadas con las recomendadas por el Programa Nacional para el Control y Eliminación de la Lepra, ya que algunas no fueron identificadas en los estudios, lo que implica pérdidas en la asistencia calificada y dirigida a las demandas del cliente, con una para el control y eliminación de la lepra. Objetivos lepra Métodos alcance 202 2023 MetaAnalyses Meta Analyses adicional Resultados 1 artículos 200 categorías oportuno físicas sociales Finales Lepra estudios cliente 20 2

ABSTRACT Objectives: to identify Primary Health Care professionals’ practice in the face of leprosy. Methods: a scoping review, carried out between November 2022 and January 2023, conducted according to the methodological structure proposed by JBI and checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews in six databases and additional literature. Results: the sample consisted of 11 articles, published between 2008 and 2022. The findings were synthesized into three categories: Early diagnosis and timely treatment; Physical disability prevention; and Household and social contact surveillance. Final Considerations: there is a need to align the practices carried out with those recommended by the Brazilian National Program for Leprosy Control and Elimination, as some were not identified in studies, which implies losses to qualified assistance directed to patient demands, with a view to control and elimination of leprosy. Objectives professionals leprosy Methods review 202 2023 MetaAnalyses Meta Analyses literature Results 1 articles 200 categories treatment prevention surveillance Considerations Elimination studies demands 20 2

RESUMO Objetivos: identificar as práticas dos profissionais de saúde da Atenção Primária diante da hanseníase. Métodos: revisão de escopo, realizada entre novembro de 2022 e janeiro de 2023, conduzida de acordo com a estrutura metodológica proposta pelo JBI e checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews em seis bases de dados e literatura adicional. Resultados: a amostra foi composta por 11 artigos, publicados entre 2008 e 2022. Os achados foram sintetizados em três categorias: Diagnóstico precoce e tratamento oportuno; Prevenção das incapacidades físicas; e Vigilância dos contatos domiciliares e sociais. Considerações Finais: há a necessidade de alinhamento das práticas realizadas com o preconizado pelo Programa Nacional de Controle e Eliminação da Hanseníase, pois algumas não foram identificadas nos estudos, o que implica prejuízos à assistência qualificada e direcionada às demandas do cliente, com vistas ao controle e eliminação da hanseníase. Objetivos hanseníase Métodos escopo 202 2023 MetaAnalyses Meta Analyses adicional Resultados 1 artigos 200 categorias oportuno físicas sociais Finais Hanseníase estudos cliente 20 2

Resumo Introdução: As experiências adversas na infância podem ter impacto em vários aspectos da saúde humana. É importante termos ferramentas que possam identificá-las e quantificá-las. Objetivo: Descrever as etapas iniciais do processo de adaptação transcultural (ATC) do Questionário Internacional de Experiências Adversas na Infância (ACE-IQ) para o português do Brasil. Método: Realizamos a avaliação da equivalência conceitual, semântica e operacional da ATC nas seguintes etapas: preparação (reuniões multidisciplinares); tradução (dois tradutores independentes); reconciliação (grupo multidisciplinar); tradução reversa (tradutor independente); revisão da tradução reversa (grupo multidisciplinar); pré-testes na população-alvo (gestantes de uma maternidade pública no Rio de Janeiro); revisão dos pré-testes (grupo multidisciplinar); prova de leitura; e relatório final (grupo multidisciplinar). Resultados: Os 43 itens do ACE-IQ foram traduzidos e adaptados para português do Brasil. Antes dos pré-testes, cinco itens dos seguintes domínios foram adaptados: etnia e escolaridade (n=2), convivência familiar (n=1) e violência entre os pares (n=2). Seguiram-se três pré-testes consecutivos (10 gestantes cada). Sete itens sofreram adaptações após o primeiro pré-teste: trabalho (n=1), casamento (n=1), relacionamento com pais/responsáveis (n=2) e ambiente familiar (n=3). Após o segundo pré-teste houve somente alteração no formato das opções de resposta. No terceiro pré-teste obteve-se índice de validade de conteúdo entre 0,89 e 1 em todos os itens. Conclusões: A versão brasileira do ACE-IQ mostrou boa equivalência conceitual, semântica e operacional na amostra estudada. Estudos de validade e confiabilidade devem ser conduzidos para confirmar suas propriedades psicométricas. Introdução humana identificálas identificá las quantificálas. quantificálas quantificá las. quantificá-las Objetivo (ATC ACEIQ ACE IQ (ACE-IQ Brasil Método conceitual reuniões multidisciplinares multidisciplinares) dois independentes independentes) grupo multidisciplinar multidisciplinar) tradutor independente independente) prétestes pré testes populaçãoalvo população alvo Janeiro Janeiro) leitura multidisciplinar. . Resultados 4 prétestes, testes, n=2, n2 n n=2 , 2 n=1 n1 (n=1 n=2. Seguiramse Seguiram se 10 (1 cada. cada cada) préteste teste n=1, paisresponsáveis pais responsáveis (n=2 n=3. n3 n=3 3 (n=3) resposta obtevese obteve 089 0 89 0,8 Conclusões estudada psicométricas n= (n= ( (n=3 08 8 0, (n

Abstract Background: Adverse childhood experiences can impact many aspects of human health. It is important to have tools that can identify and quantify them. Objective: To describe initial phases of the cross-cultural adaptation (CCA) of the Adverse Childhood Experiences International Questionnaire (ACE-IQ) to Brazilian Portuguese. Method: We conducted the conceptual, semantic and operational equivalence of the CCA process in nine steps: preparation (multidisciplinary meetings), translation (two independent translators), reconciliation (multidisciplinary group), back-translation (independent translator), back-translation review (multidisciplinary group), pre-tests with the target population (pregnant women from a public maternity hospital in Rio de Janeiro), review of pre-test results (multidisciplinary group), reading proof (multidisciplinary group); final report (multidisciplinary group). Results: The 43-item ACE-IQ has been translated and adapted to Brazilian Portuguese. Before the pre-tests, five items from the following domains were adapted: ethnicity and education (n=2), family life (n=1) and violence between peers (n=2). Three consecutive pre-tests followed (ten pregnant women, each). Seven more items were adapted after the first pre-test: work (n=1), marriage (n=1), relationship with parents/guardians (n=2), family environment (n=3). After the second pre-test, there was only a layout change in the answer options. In the third pre-test, good content validity indexes were obtained in all items (0.89–1.00). Conclusions: The Brazilian version of ACE-IQ showed good conceptual, semantic and operational equivalence in the studied sample. Validity and reliability studies are necessary to confirm its psychometric properties. Background health them Objective crosscultural cross cultural (CCA ACEIQ ACE IQ (ACE-IQ Portuguese Method conceptual steps multidisciplinary meetings, meetings , meetings) two translators, translators translators) group, group group) backtranslation back translator, translator translator) pretests pre tests Janeiro, Janeiro Janeiro) pretest test group. . Results 43item item 43 pretests, tests, n=2, n2 n n=2 2 (n=2) n=1 n1 1 (n=1 n=2. ten each. each each) n=1, parentsguardians parents guardians n=3. n3 n=3 3 (n=3) pretest, test, options 0.89–1.00. 089100 0.89–1.00 0 89 00 (0.89–1.00) Conclusions sample properties 4 n= (n=2 (n= (n=3 08910 0.89–1.0 8 (0.89–1.00 (n 0891 0.89–1. (0.89–1.0 089 0.89–1 (0.89–1. 08 0.89– (0.89–1 0.89 (0.89– 0.8 (0.89 0. (0.8 (0. (0 (

ABSTRACT This work aimed to compare the efficiency of two commercial recombinant bovine somatotropin (rbST) formulations on productive, metabolic, behavioral, and feeding parameters of mid-lactation Holstein cows. Eighteen secondiparous cows were randomly assigned to two groups to be treated with injectable rbST (rbST-Fast, Boostin ® , MSD Saúde Animal; and rbST-Slow, Lactotropin ® , Agener União Saúde Animal). Cows were rbST-treated during five cycles of 14 days each, totaling 70 days. Blood samples were collected thrice in each cycle to assess metabolic markers. Daily, automatic feeders and individual monitoring collars measured behavior and feed intake. Milk samples were collected weekly to evaluate milk composition and somatic cell count. The rbST-Fast group had higher milk production ( p = 0.03) and tended to present greater feed intake ( p = 0.07). In addition, animals treated with rbST-Fast had higher ( p < 0.01) concentrations of non-esterified fatty acids (NEFA) and tended ( p = 0.09) to have lower serum glucose values. As for the variation in body weight, cows treated with rbST-Fast lost approximately three times more weight ( p < 0.01) than rbST-Slow cows. Regarding milk components, cows from the rbST-Fast group produced milk with a higher lactose content ( p = 0.05). In conclusion, rbST-Fast treated cows produced more milk, had higher feed intake, and showed a higher degree of lipid mobilization, demonstrated through the higher body weight loss and higher NEFA concentrations. (rbST productive behavioral midlactation mid lactation rbSTFast, rbSTFast Fast, Fast (rbST-Fast Animal rbSTSlow, rbSTSlow Slow, Slow Animal. . Animal) rbSTtreated 1 7 markers Daily count 0.03 003 0 03 0.07. 007 0.07 07 0.07) addition 0.01 001 01 nonesterified non esterified (NEFA 0.09 009 09 values components 0.05. 005 0.05 05 0.05) conclusion mobilization 0.0 00 0.