ABSTRACT Objective: Intravenous non-volatile anaesthetics like propofol are commonly used in cardiac surgeries across several countries. Volatile anaesthetics like isoflurane may help in protecting the myocardium and minimize ischaemia-reperfusion injury. Hence, we did this review to compare the cardioprotective effect of isoflurane and propofol among patients undergoing coronary artery bypass grafting (CABG). Methods: We conducted a search in the databases Medical Literature Analysis and Retrieval System Online (or MEDLINE), Embase, PubMed Central®, ScienceDirect, Google Scholar, and Cochrane Library from inception until April 2021. We carried out a meta-analysis with random-effects model and reported pooled risk ratio (RR) or standardized mean difference (SMD) with 95% confidence interval (CI) depending on the type of outcome. Results: We analysed 13 studies including 808 participants. Almost all were low-quality studies. For cardiac index, the pooled SMD was 0.14 (95% CI: -0.22 to 0.50); for cardiac troponin I, pooled SMD was 0.10 (95% CI: -0.28 to 0.48). For mortality, the RR was 3.00 (95% CI: 0.32 to 28.43); for MI, pooled RR was 1.58 (95% CI: 0.59 to 4.20); and for inotropic drug use, pooled RR was 1.04 (95% CI: 0.90 to 1.21). For length of intensive care unit stay, the pooled SMD was 0.13 (95% CI: -0.29 to 0.55), while pooled SMD for mechanical ventilation time was -0.02 (95% CI: -0.54 to 0.51). Conclusion: Isoflurane did not have significant cardioprotective effect compared to propofol following CABG. Hence, the anaesthetists need to check some viable alternatives to manage these patients and reduce the rate of postoperative complications. Objective nonvolatile non volatile countries ischaemiareperfusion ischaemia reperfusion injury Hence CABG . (CABG) Methods MEDLINE, MEDLINE , MEDLINE) Embase Central Central® ScienceDirect Scholar 2021 metaanalysis meta analysis randomeffects random effects (RR (SMD 95 CI (CI outcome Results 1 80 participants lowquality low quality index 014 0 14 0.1 (95 0.22 022 22 -0.2 0.50 050 50 0.50) I 010 10 0.28 028 28 0.48. 048 0.48 48 0.48) mortality 300 3 00 3.0 032 32 0.3 28.43 2843 43 28.43) MI 158 58 1.5 059 59 0.5 4.20 420 4 20 4.20) use 104 04 1.0 090 90 0.9 1.21. 121 1.21 21 1.21) stay 013 0.29 029 29 0.55, 055 0.55 55 0.55) 0.02 002 02 -0.0 0.54 054 54 -0.5 0.51. 051 0.51 51 0.51) Conclusion complications (CABG 202 9 8 01 0. (9 0.2 2 -0. 05 5 0.4 30 3. 03 28.4 284 15 1. 4.2 42 09 12 1.2 0.0 ( -0 28. 4. -

Abstract The qualitative and quantitative sterol compositions of Sacha Inchi oil and Prinsepia oil were analysed by high-performance liquid chromatography (HPLC). The sterol compounds were mixed with citric acid, VE and other natural antioxidants and added to walnut oil, oxidation resistence was determined by the peroxide value and acid value. Gas chromatography/mass spectrometry (GC/MS) analysis was used to measure the fatty acids. The results showed that the content of β-sitosterol and stigmasterol in Sacha Inchi oil was 156.46 mg/100 g and 68.74 mg/100 g, Prinsepia oil was 176.26 mg/100 g and 38.29 mg/100 g, respectively. After 12 days of accelerated oxidation, the antioxidant effect was TBHQ > compound antioxidants > BHA > sterols of Sacha Inchi oil > sterols of Prinsepia oil > 30% Prinsepia oil > citric acid > VE. After accelerated oxidation for 48 h, the total unsaturated fatty acids in blank walnut oil showed a decreasing trend, and the antioxidant group inhibited the decrease in total unsaturated fatty acids. In conclusion, the antioxidant treatment groups can delay the oxidative cycle of walnut oil and effectively prolong the shelf life of walnut oil, and the compound groups can significantly enhance the antioxidant effect of walnut oil. This study provides a technical reference for the storage stability of walnut oil.

Abstract To observe the influence of thalidomide on tumor necrosis factor-a (TNF-α) of spontaneous type-2 diabetes rat (kk-Ay rat) model, and to explore the clinical value of TNF-a mediated inflammation approach to improve the injury on epithelial cell of kidney tubules. There are 30 kk-Ay rates being chosen to establish the Diabetic Nephropathy model and divided into thalidomide group and the model control group, 15 pieces for each group respectively. The levels of TNF-α, IL-1β, interleukin -6 (IL-6) and interleukin -18 (IL-18) of kk-Ay in the thalidomide group and the model control group were both at a higher level before treatment, but the difference was not statistically significant (P >0.05); The levels of TNF-α, IL-1β, interleukin -6 (IL-6) and interleukin -18 (IL-18) in kk-Ay rats 8/10/12 weeks after the treatment in the thalidomide group were significantly decreased, with statistically significant differences compared with the model control group (P < 0.05). The histopathological changes of kidney tubules epithelial cell injury on rats were observed through dissection. Thalidomide will effectively lower TNF-α and IL-1β expression levels in kk-Ay rat models, reduce inflammatory response, and thus improve damage on kidney tubules epithelial cell, which is worthy of further exploration and application.

By rationally introducing aromatic carboxyl functionalized 1,8-naphthalimide, a water soluble fluorescent chemosensor (DA) was successfully synthesized. It could selectively and sensitively detect CN- in pure water via an intramolecular charge transfer to twisted intramolecular charge transfer (ICT-TICT) state change mechanism. The detection limit of the chemosensor DA to CN- was 1.38 × 10−8mol L-1 which was lower than 1.9 µmol L-1 (set by the World Health Organization (WHO)). Notably, DA displayed rapid response (about 1 s) for recognizing CN- in pure water. Furthermore, DA could be applied to monitoring CN- in tap water. Meanwhile, we prepared the test strips based on DA, which could rapidly and efficiently detect CN- in water.