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1.
CHEMICAL CONSTITUENTS OF Amburana acreana Ducke A. C. Sm. LEAVES A C Sm
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Ferreira, Adrianne B.
; Aguiar, Rosane M.
; Brandão, Hugo N.
; Santos, Rauldenis A. F.
; Freitas, Humberto F. de
; Teles, Catharine
; Reis, Joice N.
; Souza, Jessica L. de
; Alves, Clayton Q.
.
This study aimed to isolate, purify and characterize secondary metabolites present in Amburana acreana leaves, native to the state of Rondônia, using classical chromatographic methods and 1D, 2D nuclear magnetic resonance spectroscopy. From the hydroethanolic leaves extract of A. acreana, p-hydroxybenzoic acid, vanillic acid, coumarin, campesterol 3-β-D-glucoside and amburoside B, all known compounds, were identified. To the best of our knowledge, this is the first report of isolation and chemical characterization of secondary metabolites in A. acreana. In addition, in vitro assays indicated that amburoside B does not have inhibitory potential on the growth of gram-negative bacteria. The presence of these compounds suggests that, thus far, amburosides (A and B) could be chemotaxonomic markers of the genus Amburana. isolate Rondônia 1D D spectroscopy A phydroxybenzoic p hydroxybenzoic acid coumarin 3βDglucoside βDglucoside 3 β glucoside identified knowledge addition gramnegative gram negative bacteria far
2.
In vitro and in silico Antifungal Activity of Metabolites from Bredemeyera brevifolia (Benth.) Klotzsch ex A.W. Benn. Benth. Benth (Benth. AW A W A.W Benn (Benth
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Barreto, Rubens S.
; Costa, Diego M. da
; Sousa, Jailan S.
; Jesus, Vilisaimon S. de
; Silva, Agnaldo P. da
; Buonafina-Paz, Maria Daniela S.
; Santos, Franz A. G. dos
; Neves, Rejane P.
; Pastore, José F. B.
; Andrade, Bruno S.
; Soares, Wagner R. A.
; Brandão, Hugo N.
; Aguiar, Rosane M.
; Alves, Clayton Q.
.
Journal of the Brazilian Chemical Society
- Métricas do periódico
Bredemeyera Willd. is a genus of the Polygalaceae family, occurring in Brazil. This research aims to evaluate the phytochemical and antifungal potential, in vitro and in silico, of Bredemeyera brevifolia extracts. The identification of fatty acids by gas chromatography-mass spectrometry and their quantification by gas chromatography-flame ionization detector showed that palmitic (36.55 mg g−1), margaric (3.66 mg g−1), linolelaidic (108.82 mg g−1), oleic (7.86 mg g−1), stearic (41.11 mg g−1), dihomo-γ-linolenic (85.48 mg g−1), and arachidic (209.00 mg g−1) acids are present in the hexane extract. From the chloroform extract, 1-hydroxy-3,7-dimethoxyxanthone was isolated and identified. The minimum inhibitory concentration assay with methanolic extract demonstrated antifungal activity against species of the genus Candida, Sporothrix, and Trichophyton for up to 96 h, with values ranging from 64-1024 μg mL−1. The in silico study with the chemical compounds of this species showed fungal inhibition potential of sterol-14-α-demethylase, highlighting 1-hydroxy-3,7-dimethoxyxanthone, which presented an affinity energy of -8.8 kcal mol−1, greater than that observed for fluconazole (−8.3 kcal mol−1). The fatty acids interacted with the active site of the enzyme but presented energies ≥ −7.4 kcal mol−1. Compounds isolated from this species have pharmacokinetic potential for the development of pharmaceutical formulations. Willd family Brazil extracts chromatographymass chromatography mass chromatographyflame flame 36.55 3655 36 55 (36.5 g−1, g1 g g−1 , 1 3.66 366 3 66 (3.6 108.82 10882 108 82 (108.8 7.86 786 7 86 (7.8 41.11 4111 41 11 (41.1 dihomoγlinolenic dihomo γ linolenic 85.48 8548 85 48 (85.4 209.00 20900 209 00 (209.0 1hydroxy3,7dimethoxyxanthone 1hydroxy37dimethoxyxanthone hydroxydimethoxyxanthone hydroxy 3,7 dimethoxyxanthone identified Candida Sporothrix 9 h 641024 64 1024 64-102 mL1 mL mL−1 sterol14αdemethylase, sterol14αdemethylase sterolαdemethylase sterol 14 α demethylase, demethylase sterol-14-α-demethylase 1hydroxy3,7dimethoxyxanthone, dimethoxyxanthone, 8.8 88 8 -8. mol1 mol mol−1 −8.3 83 (−8. . mol−1) 74 4 −7. formulations 36.5 365 5 (36. g− 3.6 6 (3. 108.8 1088 10 (108. 7.8 78 (7. 41.1 411 (41. 85.4 854 (85. 209.0 2090 20 0 (209. 1hydroxy3 7dimethoxyxanthone 37 3, 64102 102 64-10 mL− αdemethylase 8. -8 mol− −8. (−8 −7 36. (36 3. (3 108. (108 7. (7 41. (41 85. (85 209. 2 (209 1hydroxy 6410 64-1 - −8 (− − ( (10 (4 (8 (20 641 64- (1 (2
3.
In silico analysis of non-structural protein 12 sequences from SARS-COV-2 found in Manaus, Amazonas, Brazil, reveals mutations linked to higher transmissibility nonstructural non structural 1 SARSCOV2 SARSCOV SARS COV 2 SARS-COV- Manaus Amazonas Brazil SARS-COV
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ZANCHI, FERNANDO B.
; FERREIRA, GABRIEL EDUARDO M.
; MARIÚBA, LUIS ANDRÉ M.
; GLÓRIA, JULIANE C.
; NASCIMENTO, VALDINETE A. DO
; SOUZA, VICTOR C. DE
; CORADO, ANDRÉ DE LIMA G.
; NASCIMENTO, FERNANDA O. DO
; COSTA, ÁGATHA KÉLLY A. DA
; DUARTE, DÉBORA CAMILA G.
; SILVA, GEORGE ALLAN V. DA
; MEJÍA, MATILDE DEL CARMEN C.
; PESSOA, KARINA P.
; GONÇALVES, LUCIANA MARA F.
; BRANDÃO, MARIA JÚLIA P.
; JESUS, MICHELE S. DE
; SILVA, MARINEIDE S. DA
; COSTA, CRISTIANO F. DA
; NAVECA, FELIPE G.
.
Anais da Academia Brasileira de Ciências
- Métricas do periódico
Abstract The disease coronavirus COVID-19 has been the cause of millions of deaths worldwide. Among the proteins of SARS-CoV-2, non-structural protein 12 (NSP12) plays a key role during COVID infection and is part of the RNA-dependent RNA polymerase complex. The monitoring of NSP12 polymorphisms is extremely important for the design of new antiviral drugs and monitoring of viral evolution. This study analyzed the NSP12 mutations detected in circulating SARS-CoV-2 during the years 2020 to 2022 in the population of the city of Manaus, Amazonas, Brazil. The most frequent mutations found were P323L and G671S. Reports in the literature indicate that these mutations are related to transmissibility efficiency, which may have contributed to the extremely high numbers of cases in this location. In addition, two mutations described here (E796D and R914K) are close and have RMSD that is similar to the mutations M794V and N911K, which have been described in the literature as influential on the performance of the NSP12 enzyme. These data demonstrate the need to monitor the emergence of new mutations in NSP12 in order to better understand their consequences for the treatments currently used and in the design of new drugs. COVID19 19 COVID-1 worldwide SARSCoV2, SARSCoV2 SARSCoV SARS CoV 2, 2 nonstructural non structural 1 NSP (NSP12 RNAdependent dependent complex NSP1 evolution SARS-CoV- 202 Manaus Amazonas Brazil PL P L G671S GS G S efficiency location addition E796D ED E D R914K RK R K MV M V N911K NK N enzyme COVID1 COVID- (NSP1 SARS-CoV 20 (NSP
4.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
5.
Acute toxicity of essential oils of Aloysia triphylla (L’Hér.) Britton, Lippia gracilis Schauer, and Piper aduncum L. in Colossoma macropomum (Cuvier, 1818) LHér. LHér L Hér. Hér (L’Hér. Britton Schauer Cuvier, Cuvier (Cuvier 1818 (L’Hér 181 18 1
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Santos, P. R.
; Andrade-Porto, S. M.
; Oliveira, M. I. B.
; Brandão, F. R.
; Matos, L. V.
; Velásquez, J. G. R.
; Farias, C. F. S.
; Carpio, K. C. R.
; Chaves, F. C. M.
; Chagas, E. C.
.
Abstract The aim of this study was to determine the acute toxicity of the essential oils (EOs) of Aloysia triphylla, Lippia gracilis and Piper aduncum in juvenile tambaqui (Colossoma macropomum), and evaluate the possible histopathological alterations in their gills. For the acute toxicity tests, juvenile tambaqui (n=24/treatment) were distributed in six treatments with three replicates, which comprised the control and five EO concentrations of A. triphylla (60, 80, 100, 120 and 140 mg L-1), L. gracilis (35, 40, 45, 50 and 55 mg L-1) and P. aduncum (42.5, 45, 47.5, 50 and 52.5 mg L-1), with an exposure period of 4 h. The mortality rate and severity of damage to the tambaqui gills were proportional to the increase in the concentration of the EO, with LC50-4 h values estimated at 109.57 mg L -1 for A. triphylla, 41.63 mg L -1 for L. gracilis and 48.17 mg L -1 for P. aduncum. The main morphological damages observed in the gills of the tambaqui exposed to the three EOs, were Grade I: hypertrophy and hyperplasia of lamellar epithelial cells, lamellar fusion, epithelial detachment, capillary dilation and constriction, proliferation of chloride cells and mucosal cells and edema; in low frequency Grade II damage as epithelial rupture and lamellar aneurysm. Necrosis (Grade III damage) was observed only in gill lamellae exposed to P. aduncum EO (47.5, 50.0 and 52.5 mg L-1). Concentrations of EOs below LC50-4 h can be used sparingly, for short periods of exposure for the treatment of diseases in tambaqui breeding. (EOs Colossoma macropomum, macropomum , macropomum) tests n=24/treatment n24treatment ntreatment n 24 (n=24/treatment replicates A 60, 60 (60 80 100 12 14 L1, L1 1 35, 35 (35 40 45 5 L-1 P 42.5, 425 42 (42.5 475 47 47.5 525 52 52. LC504 LC LC50 LC50- 10957 109 57 109.5 - 4163 41 63 41.6 4817 48 17 48.1 I fusion detachment constriction edema aneurysm (47.5 500 0 50. L1. . sparingly breeding 2 6 (6 8 10 3 (3 L- 42.5 (42. 47. LC5 1095 109. 416 41. 481 48. (47. ( 42. (42 (47 (4
Resumo O objetivo deste estudo foi determinar a toxicidade aguda dos óleos essenciais (OEs) de Aloysia triphylla, Lippia gracilis e Piper aduncum em juvenis de tambaqui (Colossoma macropomum), e avaliar as possíveis alterações histopatológicas em suas brânquias. Para os testes de toxicidade aguda, juvenis de tambaqui (n=24/tratamento) foram distribuídos em 6 tratamentos, com três repetições, sendo o controle e cinco concentração do OE de A. triphylla (60, 80, 100, 120 e 140 mg L-1), L. gracilis (35, 40, 45, 50 e 55 mg L-1) e P. aduncum (42,5, 45, 47,5, 50 e 52,5 mg L-1), com exposição de 4 h. A taxa de mortalidade e a severidade dos danos nas brânquias de tambaqui foram proporcionais ao aumento da concentração do OE, com os valores de CL50-4 h estimados em 109,57 mg L-1 para A. triphylla, em 41,63 mg L-1 para L. gracilis e em 48,17 mg L-1 para P. aduncum. Os principais danos morfológicos observados nas brânquias de tambaqui, expostos aos três OEs, foram os de grau I: hipertrofia e hiperplasia das células do epitélio lamelar, fusão lamelar, descolamento epitelial, dilatação e constrição capilar, proliferação de células de cloreto e de células mucosas e edema; em baixa frequência os de grau II como ruptura epitelial e aneurisma lamelar. Necrose (dano de grau III) foi observado somente nas lamelas branquiais expostas ao OE de P. aduncum (47,5, 50,0 e 52,5 mg L-1). Concentrações do OEs abaixo dos valores de CL50-4 h podem ser utilizados com parcimônia, em curtos períodos de exposição para o tratamento de doenças na criação de tambaqui. (OEs Colossoma macropomum, macropomum , macropomum) n=24/tratamento n24tratamento ntratamento n 24 (n=24/tratamento tratamentos repetições 60, 60 (60 80 100 12 14 L1, L1 L 1 35, 35 (35 40 45 5 P 42,5, 425 42 (42,5 475 47 47,5 525 52 52, CL504 CL CL50 CL50- 10957 109 57 109,5 L- 4163 41 63 41,6 4817 48 17 48,1 I lamelar capilar edema dano III (47,5 500 0 50, L1. . parcimônia 2 (6 8 10 3 (3 42,5 (42, 47, CL5 1095 109, 416 41, 481 48, (47, ( 42, (42 (47 (4
6.
In vitro culture and morphology of Neoechinorhynchus buttnerae (Eoacanthocephala: Neoechinorhynchidae) collected from the intestine of tambaqui (Colossoma macropomum) farmed in the Brazilian Amazon Eoacanthocephala (Eoacanthocephala Neoechinorhynchidae Colossoma macropomum
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Oliveira, M. I. B.
; Majolo, C.
; Sebastião, F. A.
; Tavares-Dias, M.
; Brandão, F. R.
; Chagas, E. C.
.
Abstract The tambaqui (Colossoma macropomum) is a species of great economic importance for fish farming in the Brazilian Amazon, and acanthocephaliasis caused by Neoechinorhynchus buttnerae (Golvan 1956) represents an obstacle to its production due to it causing severe morphological damage to the intestinal mucosa, thus impairing the absorption of nutrients and causing weight loss in the fish. Therefore, the establishment of in vitro protocols for evaluation of anthelmintic drugs is the first step to development of effective measures for in vivo control of this endoparasite. The present study evaluated the in vitro survival of N. buttnerae maintained in Eagle’s minimum essential medium under different culture conditions. Three assays were carried out to evaluate whether temperature, supplementation with the antibiotics penicillin and streptomycin, and culture medium replacement or no replacement would influence the motility and morphology of the acanthocephalans. The results of the Kaplan-Meier analysis indicated that the use of culture in minimum essential medium together with penicillin and streptomycin prolonged the parasite’s survival when kept at temperatures of 24 °C or 28 °C. We describe herein for first time an alternative protocol that is ideal for the in vitro culture of N. buttnerae. As such, this protocol ensures greater reliability in further in vitro studies with N. buttnerae. Colossoma macropomum Amazon Golvan 1956 mucosa Therefore endoparasite N Eagles Eagle s conditions temperature acanthocephalans KaplanMeier Kaplan Meier parasites parasite 2 C such 195 19 1
Resumo O tambaqui (Colossoma macropomum) é uma espécie de grande importância econômica para a piscicultura na Amazônia brasileira, e a acantocefalose causada por Neoechinorhynchus buttnerae (Golvan 1956) representa um obstáculo à sua produção por causar severos danos morfológicos à mucosa intestinal, prejudicando a absorção de nutrientes e causando perda de peso nos peixes. Assim, o estabelecimento de protocolos in vitro para avaliação de fármacos anti-helmínticos é o primeiro passo para o desenvolvimento de medidas eficazes de controle in vivo destes endoparasitas. O presente estudo avaliou a sobrevivência in vitro de N. buttnerae mantido em meio essencial mínimo de Eagle sob diferentes condições de cultivo. Três ensaios foram realizados para avaliar se a temperatura, a suplementação com os antibióticos penicilina e estreptomicina e a substituição ou não do meio nutriente influenciariam a motilidade e a morfologia dos acantocéfalos. Os resultados da análise de Kaplan-Meier indicaram que o uso do meio essencial mínimo suplementado com penicilina e estreptomicina prolongou a sobrevivência do parasito quando mantido em temperaturas de 24 °C ou 28 °C. Este estudo descreve pela primeira vez um protocolo alternativo que é ideal para o cultivo in vitro de N. buttnerae. Este protocolo garante maior confiabilidade em ensaios in vitro com N. buttnerae. Colossoma macropomum brasileira Golvan 1956 intestinal peixes Assim antihelmínticos anti helmínticos endoparasitas N temperatura acantocéfalos KaplanMeier Kaplan Meier 2 C 195 19 1
7.
Valor do 18F-FDG PET/CT no Diagnóstico e Avaliação de Resposta ao Tratamento da Miocardite Lúpica
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Perazzo, Alvaro M.
; Andrade, Larissa G. F.
; Venancio, Leonardo G. A.
; Gouveia, Pedro Alves da Cruz
; Galvão, Mariana Feitosa Ramalho
; Lins, Esdras M.
; Moraes Neto, Fernando
; Brandão, Simone Cristina Soares
.
Arquivos Brasileiros de Cardiologia
- Métricas do periódico
8.
Benzophenone Derivatives Showed Dual Anti-Inflammatory and Antiproliferative Activities by Inhibiting COX Enzymes and Promote Cyclin E Downregulation
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Folquitto, Laís R. S.
; Souza, Thiago B. de
; Januario, Jaqueline P.
; Nascimento, Isadora M.
; Brandão, Brenda T. V.
; Moreira, Maria E. C.
; Horvath, Renato O.
; Santos, Marcelo H.
; Coelho, Luiz F. L.
; Veloso, Marcia P.
; Soares, Marisi G.
; Carvalho, Diogo T.
; Ionta, Marisa
; Chagas-Paula, Daniela A.
; Dias, Danielle F.
.
Journal of the Brazilian Chemical Society
- Métricas do periódico
Considering the promising antitumor effects of compounds with dual anti-inflammatory and antiproliferative activities, thus benzophenones analogs (2-7) were evaluated on in vivo anti-inflammatory assay and molecular docking analysis. Those with the best molecular docking results were in vitro evaluated on cyclooxygenase (COX) enzymes and tested regarding antiproliferative activity. All derivatives displayed in vivo anti-inflammatory activity. Among them, the substances 2’-hydroxy-4’-benzoylphenyl-β-D-glucopyranoside (4), 4-hydroxy-4’-methoxybenzophenone (5) and 4’-(4’’-methoxybenzoyl)phenyl-β-D-glucopyranoside (7) showed the best values of Glide Score in COX-2 docking evaluation and 4 and 5 selectively inhibited COX-2 and COX-1 in vitro enzymatic assay, respectively. Thus, 4 and 5 were tested against breast cancer (MCF-7, MDA MB-231, Hs578T) and non-small-cell-lung cancer (A549) cell lines. The estrogen-positive MCF-7 cell line was more responsive compared to other tested cell lines. They induced cell cycle arrest at G1/S transition in MCF-7 cell line once there was an increase in G0/G1 population with concomitant reduction of S population. The antiproliferative activity of these substances on MCF-7 was associated with their ability to inhibit cyclin E expression, a critical regulator of G1/S transition. Taken together, the data indicate that 4 and 5 have dual anti-inflammatory and antiproliferative activities and support further studies to evaluate their antitumor potential.
9.
Impact of COVID-19 on education, health and lifestyle behaviour of Brazilian urology residents
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Prezotti, José Antonio
; Henriques, João Victor T.
; Favorito, Luciano A.
; Canalini, Alfredo F.
; Machado, Marcos G.
; Brandão, Thulio B. V.
; Barbosa, Akemi M. V.
; Moromizato, Julyana K. M.
; Anzolch, Karin M. J.
; Fernandes, Roni de C.
; Rodrigues, Fransber R. A.
; Bellucci, Carlos H. S.
; Silva, Caroline S.
; Pompeo, Antonio Carlos L.
; Bessa Jr., Jose de
; Gomes, Cristiano M.
.
ABSTRACT Objectives: To evaluate the impact of COVID-19 on clinical and surgical practice, educational activities, health and lifestyle behavior of Brazilian urology residents. Materials and Methods: A web-based survey was sent to 468 Brazilian urology residents from postgraduate years (PGY) 3 to 5 to collect data on clinical practice and training after 4 months of COVID-19. We also assessed health-related and behavior changes, rate of infection by SARS-CoV-2, deployment to the front line of COVID-19, residents’ concerns, and access to personal protective equipment (PPE). Results: Massive reductions in elective and emergency patient consultations, diagnostic procedures and surgeries were reported across the country, affecting PGY 3 to 5 alike. Most in-person educational activities were abolished. The median damage to the urological training expected for 2020 was 6.0 [3.4 – 7.7], on a scale from 0 to 10, with senior residents estimating a greater damage (P< 0.001). Educational interventions developed included online case-based discussions, subspeciality conferences and lectures, and grand rounds. Most senior residents favored extending residency to compensate for training loss and most younger residents favored no additional training (p< 0.001). Modifications in health and lifestyle included weight gain (43.8%), reduced physical activity (68.6%), increased alcoholic intake (44.9%) and cigarette consumption (53.6%), worsening of sexual life (25.2%) and feelings of sadness or depression (48,2%). Almost half were summoned to work on the COVID-19 front-line and 24.4% had COVID-19. Most residents had inadequate training to deal with COVID-19 patients and most reported a shortage of PPE. Residents’ concerns included the risk of contaminating family members, being away from residency program, developing severe COVID-19 and overloading colleagues. Conclusions: COVID-19 had a massive impact in Brazilian urology residents´ training, health and lifestyle behavior, which may reflect what happened in other medical specialties. Studies should confirm these findings to help developing strategies to mitigate residents’ losses.
https://doi.org/10.1590/s1677-5538.ibju.2021.99.09
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10.
Identification of Flavonoids as Inhibitors of Plasmodium falciparum Enoyl-ACP Reductase by Hierarchical Virtual Screening
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Silva, Dayse A. A.
; Costa, Diego M. da
; Oliveira, Larissa M.
; Brandão, Hugo N.
; Alves, Clayton Q.
; Santos Jr., Aníbal F.
; Santos Jr., Manoelito C. dos
.
Journal of the Brazilian Chemical Society
- Métricas do periódico
Malaria, a parasitic infection caused by Plasmodium falciparum, is a serious global public health problem. The enzyme enoyl-acyl carrier protein (ACP) reductase present in a limiting step in the biosynthesis of fatty acids type II was used to search for novel molecules with potential inhibitor by virtual screening techniques. A flavonoid library obtained in ChEMBL database (n = 4,008) was filtered through physico-chemical similarity using the Euclidean distance as a criterion. The selected molecules were subjected to molecular docking using the scoring function GridScore in the DOCK 6.5 software. The top 30 ranked molecules by molecular docking were submitted to the AuPosSOM 2.1 software with the aim of clustering molecules by means of intermolecular interactions in order to understand the patterns of these interactions with enoyl-ACP reductase from Plasmodium falciparum (PfENR). We observed the importance of flavonoid moiety to hydrophobic interactions with the active site of enzyme, this confirmed the choice to study this metabolite class as PfENR inhibitors. Moreover, it was possible to recognize which intermolecular interactions contribute to the molecular recognition process.
https://doi.org/10.21577/0103-5053.20200132
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11.
Synthesis, in silico Study and Antimicrobial Activity of New Piperine Derivatives Containing Substituted δ-Esters
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Trindade, Emmely O.
; Dutra, Thalisson F.
; Brandão, Maria C. R.
; Diniz Neto, Hermes
; Lima, Edeltrudes O.
; Lira, Bruno F.
; Athayde-Filho, Petrônio F. de
; Barbosa-Filho, José M.
.
Journal of the Brazilian Chemical Society
- Métricas do periódico
A series of fifteen new piperine-derived diesters was synthesized through the substitution reaction between the salt of piperic acid, obtained through piperine basic hydrolysis, with the δ-chloro-esters, obtained through the cleavage of tetrahydrofuran (THF) with acyl chlorides in the presence of ZnCl2. The final compounds were obtained with yields ranging from 50 to 84% and were characterized by infrared (IR) and 1H and 13C nuclear magnetic resonance spectroscopy (NMR). The new compounds were evaluated in silico in regard to their ADME (absorption, distribution, metabolism, and excretion) properties, and in vitro for their antimicrobial activity against bacteria strains (Staphylococcus aureus and Pseudomonas aeruginosas), yeast fungi (Candida albicans and C. tropicalis) and filamentous fungi (Aspergillus fumigatus, A. flavus and A. niger). The results from the in silico studies of Lipinski’s rule of five showed that most compounds present good pharmacological possibilities, and the results from in vitro antimicrobial activity showed that 8 of the 15 synthesized compounds displayed antimicrobial activity, inhibiting the growth of 40-80% of tested strains, with a minimum inhibitory concentration (MIC) interval ranging from 1024 to 256 µg mL−1.
https://doi.org/10.21577/0103-5053.20200140
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12.
Phytochemical Analysis, Multi-Element Composition and Biological Activities of Extracts and Lupenone from Albizia inundata (Mart.) Barneby & J.W.Grimes
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Andrade, Eberson M. J.
; Teixeira, Jéssica S.
; Silva, Dahara K. C.
; Santos, Tatiana B. dos
; Korn, Maria G. A.
; Brandão, Hugo N.
; Ferraz, Caline G.
; Meira, Cássio S.
; Soares, Milena B. P.
; Guimarães, Elisava T.
; C. S. Neta, Lourdes
; F. S. Júnior, Aníbal
.
Journal of the Brazilian Chemical Society
- Métricas do periódico
In this study, antimicrobial activity of extracts and lupenone from A. inundata (Fabaceae, Mimosoideae), were tested. In addition, the multi-element composition of the leaves, bark and stems (heartwood) of A. inundata was evaluated using inductively coupled plasma optical emission spectrometry (ICP OES). Lupenone was isolated in the petroleum ether extract of leaves, for the first time. Biological assays were conducted to evaluate the antimicrobial (antibacterial, antifungal and antiparasitic) of extracts, their fractions and lupenone. The results showed antimicrobial and antileishmanial activity of these compounds, which may be useful for obtaining a chemical composition and biological activity database on Albizia species. For multi-element composition, we found the mean concentrations (minimum-maximum) of Al, Ca, Cr, Cu, Fe, K, Mg, Mn, Ni, P, V and Zn in the samples ranged between 0.06 and 265.41 µg g-1. Concentration ranges of Cu, Fe, Mn and Zn are large, which makes these samples as additional sources of these macronutrients.
https://doi.org/10.21577/0103-5053.20200069
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13.
Relação entre antropometría, gordura corporal e autoconceito de adolescentes do sexo feminino
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Falconi, C.A.
; Santos, T. A.
; Figueira Junior, A. J.
; Neves, A. N.
; Andrade, E. L.
; Ferreira Brandão, M. R. F.
; Zanetti, M. C.
.
ABSTRACT Excess weight caused by accumulation of body fat and increased waist circumference can cause health risks for young people, contributing to the development of early psychosocial problems and reduced quality of life of adolescents. In this context, self-concept is an important indicator of psychological well-being, especially in young age. Among the many factors that may contribute to the perception of self-concept is the body composition, which is constantly modified in this phase of life. In this sense, excessive accumulation of body fat and increased abdominal circumference may be associated with positive or negative self-concepts, favoring the development of psychosocial factors in the young population for healthy behaviors. Thus, this study sought to analyze the relationship of waist circumference, fat percentage and the physical and global self-concept of female adolescents. For that, a cross-sectional study was carried out with the participation of 101 female adolescents, students of the High School of a State Technical School of the city of São Paulo. The Harter self-perception scale for adolescents was validated for Brazilian adolescents, in the dimensions of physical and global self-concept, and anthropometric measures of body mass and height were checked for BMI (body mass index), skin folds for the percentage of fat and perimeters for waist circumference. A small inverse correlation was found between the variables physical self-concept and waist circumference corroborating with other studies that indicated similar results.
RESUMO O excesso de peso causado pelo acúmulo de gordura corporal e a circunferência de cintura aumentada podem ocasionar riscos à saúde dos jovens, contribuindo para o desenvolvimento de problemas psicossociais precoces e redução da qualidade de vida do adolescente. Nesse contexto, o autoconceito é um importante indicador de bem-estar psicológico, principalmente na idade jovem. Dentre os inúmeros fatores que podem contribuir para a percepção do autoconceito está a composição corporal, que é constantemente modificada nessa fase da vida. Nesse sentido, o acúmulo excessivo de gordura corporal e o aumento da circunferência abdominal podem estar associadas a autoconceitos positivos ou negativos sobre si mesmo, favorecendo o desenvolvimento de fatores psicossociais da população jovem em prol de comportamentos saudáveis ou não. Assim, esse trabalho buscou analisar a relação da circunferência de cintura, o percentual de gordura e o autoconceito físico e global de adolescentes do sexo feminino. Para isso, foi realizado um estudo transversal com a participação de 101 adolescentes do sexo feminino, estudantes do Ensino Médio de uma Escola Técnica Estadual da cidade de São Paulo. Foi utilizada a escala de Autopercepção de Harter para Adolescentes validada para adolescentes Brasileiros, nas dimensões do autoconceito físico e global, e aferidas medidas antropométricas de massa corporal e estatura para a verificação do IMC (índice de massa corporal), pregas cutâneas para o percentual de gordura e perímetros para a circunferência de cintura. Foi encontrada uma correlação pequena e inversa entre as variáveis autoconceito físico e circunferência de cintura corroborando com outros estudos que apontaram resultados similares.
RESUMEN El exceso de peso causado por la acumulación de grasa corporal y la circunferencia de cintura aumentada pueden ocasionar riesgos para la salud de los jóvenes, contribuyendo al desarrollo de problemas psicosociales precoces y reducción de la calidad de vida del adolescente. En ese contexto, el autoconcepto es un importante indicador de bienestar psicológico, principalmente en la edad joven. Entre los innumerables factores que pueden contribuir a la percepción del autoconcepto está la composición corporal, que es constantemente modificada en esa fase de la vida. En este sentido, la acumulación excesiva de grasa corporal y el aumento de la circunferencia abdominal pueden estar asociadas a autoconceptos positivos o negativos sobre sí mismo, favoreciendo el desarrollo de factores psicosociales de la población joven en pro de comportamientos sanos o no. Así, ese trabajo buscó analizar la relación de la circunferencia de cintura, el porcentaje de grasa y el autoconcepto físico y global de adolescentes del sexo femenino. Para ello, se realizó un estudio transversal con la participación de 101 adolescentes del sexo femenino, estudiantes de la Enseñanza Media de una Escuela Técnica Estadual de la ciudad de São Paulo. Se utilizó la escala de Autopercepción de Harter para Adolescentes validada para adolescentes brasileños, en las dimensiones del autoconcepto físico y global, y medidas medidas antropométricas de masa corporal y estatura para la verificación del IMC (índice de masa corporal), pliegues cutáneos para el porcentual de masa corporal grasa y perímetros para la circunferencia de cintura. Se encontró una correlación pequeña e inversa entre las variables autoconcepto físico y circunferencia de cintura corroborando con otros estudios que apuntar resultados similares.
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14.
Synthesis by Click Reactions and Antiplasmodial Activity of Lupeol 1,2,3-Triazole Derivatives
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Borgati, Tatiane F.
; Pereira, Guilherme R.
; Brandão, Geraldo C.
; Santos, Juliana O.
; Fernandes, Dayane Aparecida M.
; Paula, Renata C. de
; Nascimento, Maria Fernanda A. do
; Soares, Luciana F.
; Lopes, Júlio César D.
; Souza Filho, José D. de
; Oliveira, Alaíde B. de
.
Journal of the Brazilian Chemical Society
- Métricas do periódico
Lupeol, a triterpene frequently found in Asteraceae plant species, showed moderate to low activity in different strains of Plasmodium falciparum, the most virulent malaria etiological agents. In this work, lupeol was isolated from Parahancornia fasciculata, a plant that is used to treat malaria in the Amazonia region. In the search of more activity lupeol derivatives, five new 1,2,3-triazole hybrid molecules were synthetized by copper-catalyzed azide-alkyne cycloaddition. The antiplasmodial activity of the semi-synthetic compounds were evaluated by the lactate dehydrogenase assay; the lupeol propargyl ether was the only one to disclosing increased activity (half maximal inhibitory concentration-IC50-62.0 ± 1.92 µmol L-1) in relation to lupeol (IC50 117.00 µmol L-1). Therefore, this work revealed a new class of interesting lupeol derivatives that can be obtained by linking electron donors to the hydroxy group at C-3.
https://doi.org/10.21577/0103-5053.20170013
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15.
Analysis of steel bars corrosion as a function of the environment pH
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RESUMO O objetivo deste estudo é analisar como o tipo de aço, o pH do meio e a proteção superficial da barra de aço são capazes de alterar as propriedades eletroquímicas deste metal. Para isso, foi aplicada a técnica de polarização linear em barras de aço para avaliar a corrosão das amostras. No estudo foram avaliados os aços CA-50, CA-60 e CP-175-RB, com e sem proteção superficial. Estudos como este são essenciais para o aprimoramento das técnicas de leitura, em especial para o entendimento dos resultados obtidos em reparos já realizados. A partir dos resultados foi possível observar como as três variáveis analisadas influenciaram os resultados da densidade de corrente e da taxa de corrosão.
ABSTRACT The aim of this study is to analyze how the steel type, the environment pH and surface protection of steel bars are able to change the electrochemical properties of this metal. Therefore, it was applied the linear polarization technique to steel bars to assess the corrosion of the samples. The study evaluated the CA-50, CA-60 and CP-175-RB steels bar, with and without surface protection. Studies like this are essential for the improvement of reading techniques, especially for the understanding of the results obtained in repairs already made. From the results, it was possible to observe how the three variables influenced the results of the current density and corrosion rate.
RESUMEN El objetivo de este estudio es analizar cómo el tipo de acero, el pH del medio y la protección de la superficie de la barra de acero son capaces de cambiar las propiedades electroquímicas de este metal. Para esto se aplicó la técnica de polarización lineal en barras de acero para evaluar la corrosión de las muestras. El estudio evaluó los aceros CA-50, CA-60 y CP-175-RB, con y sin protección superficial. Estudios como éste son esenciales para la mejora de las técnicas de lectura, especialmente para la comprensión de los resultados obtenidos en las reparaciones ya realizadas. A partir de los resultados fue posible observar cómo las tres variables influyeron en los resultados de la densidad de corriente y velocidad de corrosión.
https://doi.org/10.21041/rav6i3.153
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