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1.
Olhares improváveis: em memória de José Mattoso
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Moreira, António Montes
; Azevedo, Carlos A. Moreira
; Barroca, Mário Jorge
; Martínez, Carlos de Ayala
; Rêpas, Luís Miguel
; Ramos, Rui
; Teixeira, Alfredo
.
2.
Production and Characterization of Pb-Carbon Composite for Manufacturing Metal Grids Applied in Lead-Acid Batteries PbCarbon Pb Carbon LeadAcid Lead Acid
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Cossu, Caio Marcello Felbinger Azevedo
; Freitas, Heverson Renan de
; Conceição, Monique Osório Talarico da
; Rodrigues, Liana Alvares
; Berton, Marco Antonio Coelho
; Nunes, Carlos Angelo
.
For decades, lead-acid batteries have been supplying power to electrical systems through redox reactions involving Pb and PbO2. However, the energy supply capacity is inherently constrained by low energy density and challenges associated with charge/discharge cycles. Studies have indicated that additions of C to the composition of the active mass improve the electrochemical properties of batteries. This work aims to produce, characterize the microstructure and evaluate the electrochemical properties of Pb-Carbon composites, comparing different types of C (graphite, graphene and xerogel). The samples were produced through powder metallurgy, pressed at 550 MPa and sintered at 320°C-48 h. The microstructure was characterized by XRD, SEM/EDS, and Vickers microhardness. Electrochemical analyses were evaluated through OCP, polarization, and cyclic voltammetry (CV) measurements in a solution of 4.91 mol•L-1 of H2SO4. Microstructural characterizations revealed dispersions of C particles in the Pb matrix and an increase in the microhardness of the composites. Electrochemical analyses showed an increase in polarization resistance and a reduction in the corrosion rate compared to Pb. CV curves, demonstrated that C particles enhanced electrical conductivity for the formation of PbSO4 and PbO2, allowing greater absorption of electrical overpotentials when compared to Pb, thereby improving charge/discharge cycles in positive grids. decades leadacid lead acid PbO2 PbO However chargedischarge charge discharge produce PbCarbon Carbon composites graphite, graphite (graphite xerogel. xerogel . xerogel) metallurgy 55 320°C48 320C48 320°C 48 320 320°C-4 h XRD SEMEDS SEM EDS SEM/EDS OCP (CV 491 4 91 4.9 mol•L1 molL1 molL mol•L 1 mol L mol•L- H2SO4 HSO H SO curves PbSO grids 5 C48 320°C4 320C4 320C 32 320°C- 49 9 4. L1 H2SO C4 3
3.
COVID-19 in hematopoietic stem cell transplant recipients during three years of the pandemic: a multicenter study in Brazil COVID19 COVID 19 COVID-1 pandemic COVID1 1 COVID-
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Randi, Bruno Azevedo
; Higashino, Hermes Ryoiti
; Silva, Vinícius Ponzio da
; Salomão, Matias Chiarastelli
; Pignatari, Antonio Carlos Campos
; Abdala, Edson
; Vasques, Fabiana
; Silva, Celso Arrais Rodrigues da
; Silva, Roberto Luiz da
; Lazari, Carolina dos Santos
; Levi, José Eduardo
; Xavier, Erick Menezes
; Côrtes, Marina Farrel
; Luna-Muschi, Alessandra
; Rocha, Vanderson
; Costa, Silvia Figueiredo
.
Revista do Instituto de Medicina Tropical de São Paulo
- Métricas do periódico
ABSTRACT Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022. The primary outcome was all-cause mortality. Of 49 cases, 63.2% were male with a median age of 47 years. Allogeneic-HSCT (51.2%) and autologous-HSCT (48.9%) patients were included. The median time from HSCT to COVID-19 diagnosis was 398 days (IQR: 1211-134), with 22 (44.8%) cases occurring within 12 months of transplantation. Most cases occurred during the first year of the pandemic, in non-vaccinated patients (n=35; 71.4%). Most patients developed severe (24.4%) or critical (40.8%) disease; 67.3% received some medication for COVID-19, primarily corticosteroids (53.0%). The probable invasive aspergillosis prevalence was 10.2%. All-cause mortality was 40.8%, 51.4% in non-vaccinated patients and 14.2% in patients who received at least one dose of the vaccine. In the multiple regression analyses, the variables mechanical ventilation (OR: 101.01; 95% CI: 8.205 – 1,242.93; p = 0.003) and chest CT involvement at diagnosis ≥50% (OR: 26.61; 95% CI: 1.06 – 664.26; p = 0.04) remained associated with all-cause mortality. Thus, HSCT recipients with COVID-19 experienced high mortality, highlighting the need for full vaccination and infection prevention measures. (HSCT increased COVID19. COVID19 COVID 19. 19 COVID-1 Paulo postHSCT, postHSCT post HSCT, post-HSCT 202 2022 allcause all cause 4 632 63 2 63.2 years AllogeneicHSCT Allogeneic 51.2% 512 51 (51.2% autologousHSCT autologous 48.9% 489 48 9 (48.9% included 39 IQR (IQR 1211134, 1211134 1211 134 , 1211-134) 44.8% 448 44 8 (44.8% 1 transplantation pandemic nonvaccinated non vaccinated n=35 n35 n 35 (n=35 71.4%. 714 71.4% . 71 71.4%) 24.4% 244 24 (24.4% 40.8% 408 40 (40.8% disease 673 67 3 67.3 COVID19, 19, 53.0%. 530 53.0% 53 0 (53.0%) 102 10 10.2% Allcause All 514 51.4 142 14 14.2 vaccine analyses OR (OR 101.01 10101 101 01 95 CI 8205 205 8.20 1,242.93 124293 242 93 0.003 0003 003 50 ≥50 26.61 2661 26 61 106 06 1.0 664.26 66426 664 0.04 004 04 Thus measures COVID1 COVID- 20 6 63. 51.2 5 (51.2 48.9 (48.9 121113 121 13 1211-134 44.8 (44.8 n=3 n3 (n=3 71.4 7 24.4 (24.4 40.8 (40.8 67. 53.0 (53.0% 10.2 51. 14. 101.0 1010 820 8.2 1,242.9 12429 0.00 000 00 ≥5 26.6 266 1. 664.2 6642 66 0.0 (51. 48. (48. 12111 1211-13 44. (44. n= (n= 71. 24. (24. 40. (40. 53. (53.0 10. 101. 82 8. 1,242. 1242 ≥ 26. 664. 0. (51 (48 1211-1 (44 (n (24 (40 (53. 1,242 124 (5 (4 1211- (2 (53 1,24 ( 1,2 1,
4.
Chemical and mineralogical constitution of redoximorphic features and mechanism of formation of Plinthosols from the Araguaia River plain, Brazil plain
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Santos, Djavan Pinheiro
; Santos, Glenio Guimarães
; Oliveira, Virlei Álvaro de
; Silva, Gustavo Cassiano da
; Flores, Rilner Alves
; Azevedo, Antônio Carlos
; Souza Júnior, Valdomiro Severino de
; Pereira, Marcos Gervasio
.
ABSTRACT Currently in Brazil, large grain cultivation projects on Plinthosols are a reality, however, there is little or no knowledge of the real mechanism of formation of the plinthite feature, in addition to what is reported in the literature as being a product of oxidation-reduction processes of iron element. This study evaluates iron redoximorphic features and investigates their chemical and mineralogical composition in two profiles of Plinthosols from the Araguaia River plain (P1 and P2). The study strengthens the understanding of the pedogenetic processes involved in the formation of mottles and plinthite. In this sense, it assesses whether the formation mechanisms corroborate the literature. Soil features were sampled in the upper right and left position at the initial plinthic horizon, upper right and left position at the main plinthic horizon, and lower right position at the base horizon of the plinthite zone in the profile. Separated samples comprising the soil matrix, mottles, and plinthite under natural moisture conditions were ground into powder form for chemical determinations by X-ray fluorescence (XRF), sulfuric acid attack (H2SO4), sodium dithionite-citrate-bicarbonate (DCB), and ammonium acid oxalate; and mineralogical determinations by X-ray diffraction. Iron contents in all determined forms were always higher in the plinthite feature, intermediate in the mottle feature, and lower in the soil matrix feature. Most of the Fe in all redoximorphic features is included in the structure of primary minerals and their derivatives (vermiculite, illite, and VHEs). Only part of the iron present (about 35.40 % in P1 and 41.98 % in P2) is detected in the form of oxides such as goethite and hematite, which could be formed in redox processes. The mottle and plinthite features under study are not the product of the classic process of segregation, mobilization, and accumulation of iron as a consequence of redox processes. These features were formed or emerged as a result of a relatively slow and constant weathering process of their source material, which is gradually decomposed in an aqueous medium, releasing most of its components. These components include iron and more mobile elements such as bases and silicon, which leave the system through drainage water, and of which a small part may eventually recombine to form new less complex minerals such as kaolinite and oxides. Brazil reality however feature oxidationreduction oxidation reduction element P (P P2. P2 . sense profile Xray X ray XRF, XRF , (XRF) H2SO4, H2SO4 HSO H SO (H2SO4) dithionitecitratebicarbonate dithionite citrate bicarbonate DCB, DCB (DCB) oxalate diffraction vermiculite, vermiculite (vermiculite illite VHEs. VHEs VHEs) about 3540 35 40 35.4 4198 41 98 41.9 hematite segregation mobilization material medium silicon water (XRF H2SO (H2SO4 (DCB 354 3 4 35. 419 9 41. (H2SO
5.
Soil hydraulic properties, mineralogical alteration and pore formation in Regosols from southern Brazil properties
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Pedron, Fabrício de Araújo
; Deobald, Gabriel Antônio
; Gubiani, Paulo Ivonir
; Santos, Luís Antônio Coutrim dos
; Azevedo, Antônio Carlos de
; Reichert, José Miguel
; Dambroz, Alice Prates Bisso
.
ABSTRACT Regosols (Neossolos) are soils with use limitations mainly related to effective depth, abundant presence of rock and saprolite fragments, and frequently high slope gradients; besides that, they represent a new agricultural frontier for grain production in southern Brazil. This study evaluated soil saturated hydraulic conductivity (Ksat) and water retention and availability in Regosols and saprolites derived from volcanic rocks in southern Brazil and the relationship of these variables with porosity in saprolithic horizons characterized by mineralogical weathering. The study was carried out on eight profiles derived from basic and acidic volcanic rocks of the Serra Geral Formation. We evaluated soil morphology, granulometry, porosity, bulk density (BD), Ksat, water retention, electronic/ optical microscopy and chemical composition of parent materials, and soil mineralogy. Soil Ksat ranged from 0.0 to 6.40 cm h-1 in the evaluated horizons, without significant difference between the A and Cr horizons. Seven soil profiles showed BD equal to or less than 1.28 Mg m-3 for the Cr samples. Total porosity in the Cr horizons was above 0.5 m3 m-3 and not significantly different from A horizons. In five of the eight soil profiles, one or more Cr horizons presented greater available water than A horizons. Electronic and optical microscopy evidenced abundant cracks and mineralogical weathering in the rock samples. X-rays diffraction data also indicated advanced degree of weathering of Cr horizons, evidencing abundant formation of pores in the saprolite. and justifying the high-water retention in Regosols profiles in southern Brazil. Neossolos (Neossolos depth fragments gradients that (Ksat Formation morphology granulometry BD, , (BD) electronic materials mineralogy 00 0 0. 640 6 40 6.4 h1 h 1 h- 128 28 1.2 m 3 m- samples 05 5 Xrays X rays highwater (BD 64 4 6. 12 2 1.
6.
Vaccination coverage, delay and loss to follow-up of the triple viral vaccine, in live births between 2017 and 2018 in Brazilian cities coverage followup follow up vaccine 201 20 2
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D’Agostini, Tatiana Lang
; Zambom, Fernanda Florencia Fregnan
; Moraes, José Cássio de
; França, Ana Paula
; Camargo, Jéssica Pires de
; Ribeiro, Manoel Carlos Sampaio de Almeida
; Barata, Rita Barradas
; Silva, Adriana Ilha da
; Ramos Jr., Alberto Novaes
; França, Ana Paula
; Oliveira, Andrea de Nazaré Marvão
; Boing, Antonio Fernando
; Domingues, Carla Magda Allan Santos
; Oliveira, Consuelo Silva de
; Maciel, Ethel Leonor Noia
; Guibu, Ione Aquemi
; Mirabal, Isabelle Ribeiro Barbosa
; Barbosa, Jaqueline Caracas
; Lima, Jaqueline Costa
; Moraes, José Cássio de
; Luhm, Karin Regina
; Caetano, Karlla Antonieta Amorim
; Lima, Luisa Helena de Oliveira
; Antunes, Maria Bernadete de Cerqueira
; Teixeira, Maria da Gloria
; Teixeira, Maria Denise de Castro
; Borges, Maria Fernanda de Sousa Oliveira
; Queiroz, Rejane Christine de Sousa
; Gurgel, Ricardo Queiroz
; Barata, Rita Barradas
; Azevedo, Roberta Nogueira Calandrini de
; Oliveira, Sandra Maria do Valle Leone de
; Teles, Sheila Araújo
; Gama, Silvana Granado Nogueira da
; Mengue, Sotero Serrate
; Simões, Taynãna César
; Nascimento, Valdir
; Araújo, Wildo Navegantes de
.
RESUMO Objetivo Estimar cobertura vacinal, atraso e perda de seguimento da vacina tríplice viral, em crianças até 24 meses residentes em cidades brasileiras. Método Inquérito domiciliar baseado em uma coorte retrospectiva de nascidos vivos em 2017-2018, que analisou cobertura e dados sociodemográficos das crianças e famílias, a partir dos registros da caderneta de vacinação e entrevista. Resultados A cobertura válida da primeira dose foi de 90,0% (IC95% 88,9;91,0), e da segunda, e 81,1% (IC95% 79,8;82,4). O atraso para ambas as doses foi de 23,2% (IC95% 21,9;24,5) e a perda de seguimento de 10,8% (IC95% 9,9;11,8). O estrato socioeconômico A apresentou menor cobertura e, à medida que a ordem de nascimento aumentava, menor era a cobertura para as duas doses. Crianças de mães com 13 a 15 anos de escolaridade apresentaram maior cobertura. Conclusão As coberturas não alcançaram a meta preconizada. Estratégias diferenciadas para dirimir dificuldade de acesso, desinformação e hesitação poderão melhorar a cobertura. vacinal viral 2 brasileiras 20172018, 20172018 2017 2018, 2018 2017-2018 famílias entrevista 900 90 0 90,0 IC95% IC95 IC (IC95 88,991,0, 889910 88,9 91,0 , 88 9 91 88,9;91,0) segunda 811 81 1 81,1 79,882,4. 798824 79,8 82,4 . 79 8 82 4 79,8;82,4) 232 23 23,2 21,924,5 219245 21,9 24,5 21 5 21,9;24,5 108 10 10,8 9,911,8. 99118 9,9 11,8 11 9,9;11,8) aumentava preconizada acesso 2017201 201 2017-201 90, IC9 (IC9 991 88,991,0 88991 889 88, 910 91, 88,9;91,0 81, 882 79,882,4 79882 798 79, 824 82, 7 79,8;82,4 23, 924 21,924, 21924 219 21, 245 24, 21,9;24, 10, 911 9,911,8 9911 99 9, 118 11, 9,9;11,8 201720 20 2017-20 (IC 88,991, 8899 88,9;91, 79,882, 7988 79,8;82, 92 21,924 2192 21,9;24 9,911, 9,9;11, 20172 2017-2 88,991 88,9;91 79,882 79,8;82 21,92 21,9;2 9,911 9,9;11 2017- 88,99 88,9;9 79,88 79,8;8 21,9; 9,91 9,9;1 88,9; 79,8; 9,9;
ABSTRACT Objective To estimate measles-mumps-rubella vaccination coverage, delay and loss to follow-up in children up to 24 months old living in Brazilian cities. Methods Surveys and questionnaires with a retrospective cohort of live births in 2017-2018, analyzing vaccination coverage and sociodemographic data of children and families, based on vaccination card records and interviews. Results Valid coverage of first dose was 90.0% (95%CI 88.9;91.0) and 81.1% for the second dose (95%CI 79.8;82.4). Delay for both doses was 23.2% (95%CI 21.9;24.5) and loss to follow-up was 10.8% (95%CI 9.9;11.8). Socioeconomic stratum A had the lowest vaccination coverage and the higher the child’s birth order, the lower the vaccination coverage for the second dose. Children whose mothers had 13 to 15 years of education had higher vaccination coverage. Conclusion Coverage did not meet the recommended target. Differentiated strategies to resolve difficulties in access, misinformation, and vaccination hesitancy will help improve vaccination coverage. measlesmumpsrubella measles mumps rubella followup follow 2 cities 20172018, 20172018 2017 2018, 2018 2017-2018 families interviews 900 90 0 90.0 95%CI 95CI CI 95 88.991.0 889910 88.9 91.0 88 9 91 88.9;91.0 811 81 1 81.1 79.882.4. 798824 79.8 82.4 . 79 8 82 4 79.8;82.4) 232 23 23.2 21.924.5 219245 21.9 24.5 21 5 21.9;24.5 108 10 10.8 9.911.8. 99118 9.9 11.8 11 9.9;11.8) childs child s order target access misinformation 2017201 201 2017-201 90. 991 88.991. 88991 889 88. 910 91. 88.9;91. 81. 882 79.882.4 79882 798 79. 824 82. 7 79.8;82.4 23. 924 21.924. 21924 219 21. 245 24. 21.9;24. 10. 911 9.911.8 9911 99 9. 118 11. 9.9;11.8 201720 20 2017-20 88.991 8899 88.9;91 79.882. 7988 79.8;82. 92 21.924 2192 21.9;24 9.911. 9.9;11. 20172 2017-2 88.99 88.9;9 79.882 79.8;82 21.92 21.9;2 9.911 9.9;11 2017- 88.9; 79.88 79.8;8 21.9; 9.91 9.9;1 79.8; 9.9;
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7.
Precipitation of amorphous iron and aluminum during the weathering of rock dust in soil columns
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Silva, Rafael Cipriano da
; Guimarães, Clécia Cristina Barbosa
; Azevedo, Antonio Carlos de
; Alves, Marcelo Rodrigo
; Demattê, José Alexandre Melo
.
ABSTRACT The application of rock dust (RD) in agricultural soils has shown the capacity to improve soil conditions for plant growth. However, the successful use of RD requires understanding its effects on weathering in soil surfaces and its possible products. In this study, we present the results of an exploratory test in which a RD had its weathering intensified in a soil column by temperature (45 °C) and intense leaching (1,339.2 mm in 24 weeks), in the absence of plants. There was a significant increase in amorphous phases of iron (Fe) and particularly of aluminum (Al) to the amount of 0.13 g kg –1 for Fe and 0.16 g kg –1 for Al in the 0-0.05 m layer of the column and 0.22 g kg –1 for Al in the 0.05-0.10 m layer. These values account for 6 % of the total Fe, and 27 % of the total Al added as RD in the column. Spectral features in the visible-near infrared-short wave infrared (VIS-NIR-SWIR) and mid-infrared (MIR) range, as well as X-ray diffraction (XRD) scans, were inconclusive because of the small signal-noise ratio of the newly precipitated phases. Selective chemical methods targeted to specific soil pools (precipitated, adsorbed, and leached) were more sensitive to capture the new amorphous phases resulting from the RD dissolution. This study contributes to understanding the effects of RD on the availability of ions and the possibility of amorphous oxides precipitating in the soil. In addition, it helps identify other effects associated with using RD, such as changes in the pH, cation exchange capacity (CEC), and nutrient availability. (RD growth However products 45 (4 °C C 1,339.2 13392 1 339 2 (1,339. weeks, weeks , weeks) plants (Fe (Al 013 0 13 0.1 – 016 16 00.05 0005 0.05 05 0-0.0 022 22 0.2 0.050.10 005010 0.10 10 0.05-0.1 visiblenear visible near infraredshort short VISNIRSWIR VIS NIR SWIR (VIS-NIR-SWIR midinfrared mid MIR (MIR range Xray X ray XRD (XRD scans signalnoise signal noise precipitated, (precipitated adsorbed leached dissolution addition pH CEC, CEC (CEC) 4 ( 1,339. 1339 33 (1,339 01 0. 00 00.0 000 005 0.0 0-0. 02 050 0.050.1 00501 010 0.05-0. (CEC 1,339 133 3 (1,33 00. 0-0 0.050. 0050 0.05-0 1,33 (1,3 0- 0.050 0.05- 1,3 (1, 1, (1
8.
VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation): protocol for a multicenter randomized open-label trial of watchful waiting versus antimicrobial therapy for ventilator-associated tracheobronchitis VentilatorAssociated Ventilator Associated Evaluation Evaluation) openlabel open label ventilatorassociated ventilator associated
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Tomazini, Bruno Martins
; Besen, Bruno Adler Maccagnan Pinheiro
; Dietrich, Camila
; Gandara, Ana Paula Rossi
; Silva, Debora Patrícia
; Pinheiro, Carla Cristina Gomes
; Luz, Mariane Nascimento
; Mattos, Renata Rodrigues de
; Reis, Luiz Fernando Lima
; Roepke, Roberta Muriel Longo
; Duarte, Carlos Sérgio Luna Gomes
; Nassar Júnior, Antônio Paulo
; Veiga, Viviane Cordeiro
; Arns, Beatriz
; Nascimento, Giovanna Marssola
; Pereira, Adriano José
; Cavalcanti, Alexandre Biasi
; Machado, Flávia Ribeiro
; Azevedo, Luciano Cesar Pontes
.
RESUMO Contexto A traqueobronquite associada ao ventilador é uma condição comum entre pacientes ventilados invasivamente em unidades de terapia intensiva, para a qual se desconhece atualmente a melhor estratégia de tratamento. Desenhamos o estudo VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation) para avaliar se uma estratégia de tratamento antibiótico de espera vigilante não é inferior ao tratamento antibiótico de rotina para traqueobronquite associada ao ventilador em relação aos dias sem ventilador mecânico. Métodos O VATICAN é um estudo randomizado, controlado, aberto e multicêntrico de não inferioridade. Os pacientes com suspeita de traqueobronquite associada ao ventilador sem evidência de pneumonia associada ao ventilador ou instabilidade hemodinâmica devido a uma provável infecção serão designados para uma estratégia de espera vigilante, sem administração profilática de antimicrobianos contra traqueobronquite associada ao ventilador e prescrição de antimicrobianos somente em casos de pneumonia associada ao ventilador, sepse ou choque séptico, ou outro diagnóstico infeccioso, ou para uma estratégia de tratamento antimicrobiano de rotina por 7 dias. O desfecho primário será o número de dias sem ventilador mecânico em 28 dias, e um desfecho secundário importante será a sobrevida sem pneumonia associada ao ventilador. Por meio de uma estrutura de intenção de tratar com análise de sensibilidade por protocolo, a análise do desfecho primário abordará a não inferioridade com margem de 20%, o que se traduz em uma diferença de 1,5 dia sem ventilador. Outras análises seguirão uma estrutura de análise de superioridade. Conclusão O VATICAN seguirá todos os padrões éticos nacionais e internacionais. O objetivo é publicar o estudo em um periódico geral de alta visibilidade e apresentá-lo em conferências de cuidados intensivos e doenças infecciosas para divulgação. Estes resultados provavelmente serão imediatamente aplicáveis à beira do leito após a conclusão do estudo e fornecerão informações com baixo risco de viés para o desenvolvimento de diretrizes. intensiva VentilatorAssociated Ventilator Associated Evaluation randomizado controlado séptico infeccioso 2 protocolo 20 20% 15 1 5 1, superioridade internacionais apresentálo apresentá lo divulgação diretrizes
ABSTRACT Background Ventilator-associated tracheobronchitis is a common condition among invasively ventilated patients in intensive care units, for which the best treatment strategy is currently unknown. We designed the VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation) trial to assess whether a watchful waiting antibiotic treatment strategy is noninferior to routine antibiotic treatment for ventilator-associated tracheobronchitis regarding days free of mechanical ventilation. Methods VATICAN is a randomized, controlled, open-label, multicenter noninferiority trial. Patients with suspected ventilator-associated tracheobronchitis without evidence of ventilator-associated pneumonia or hemodynamic instability due to probable infection will be assigned to either a watchful waiting strategy, without antimicrobial administration for ventilator-associated tracheobronchitis and prescription of antimicrobials only in cases of ventilator-associated pneumonia, sepsis or septic shock, or another infectious diagnosis, or to a routine antimicrobial treatment strategy for seven days. The primary outcome will be mechanical ventilation-free days at 28 days, and a key secondary outcome will be ventilator-associated pneumonia-free survival. Through an intention-to-treat framework with a per-protocol sensitivity analysis, the primary outcome analysis will address noninferiority with a 20% margin, which translates to a 1.5 difference in ventilator-free days. Other analyses will follow a superiority analysis framework. Conclusion The VATICAN trial will follow all national and international ethical standards. We aim to publish the trial in a high-visibility general journal and present it at critical care and infectious disease conferences for dissemination. These results will likely be immediately applicable to the bedside upon trial completion and will provide information with a low risk of bias for guideline development. Ventilatorassociated Ventilator associated units unknown VentilatorAssociated Associated Evaluation ventilatorassociated ventilator ventilation randomized controlled openlabel, openlabel open label, label open-label shock diagnosis ventilationfree 2 pneumoniafree survival intentiontotreat intention treat perprotocol per protocol 20 margin 15 1 5 1. ventilatorfree standards highvisibility high visibility dissemination development
9.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
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; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
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; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
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; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
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; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
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; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
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; Manfio, Daiara
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; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
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; Gallardo, Fabiana
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; Mauro, Fabio
; Nascimento, Fabio O. do
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; Prando, Jadila S.
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; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
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; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
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; Segadilha, Juliana L.
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; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
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; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
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; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
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; Salik, Lucy M.
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; Silveira, Luis F.
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; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
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; Sekerka, Lukas
; Barros, Lurdiana D.
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; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
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; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
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; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
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; Fernandez, Monica A.
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; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
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; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
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; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
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; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
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; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
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; Coelho, Paulo R.S.
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; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
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; Bartholomay, Pedro R.
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; Silva, Rafael A.P.F.
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; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
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; Siewert, Ricardo
; Brugnera, Ricaro
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; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
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; Feitosa, Rodrigo M.
; Hutchings, Roger W.
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; Gerstmeier, Roland
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; Rocha, Rosana M. da
; Tidon, Rosana
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; Santos, Sandra D. dos
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ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
10.
Experimental studies on freshwater zooplankton in Brazil: a scientometric analysis from 1978 to 2023 Brazil 197 202 19 20 1 2
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Portinho, Jorge Laço
; Brandão, Larissa Ferreira
; Machado, Marco Antonio Azevedo
; Nova, Clarice Casa
; Bandeira, Maiby Glorize da Silva
; Dias, Juliana Deo
; Ferreira, Amanda Costa
; Bozelli, Reinaldo Luiz
.
Resumo Objetivo Este estudo tem como objetivo contribuir para elucidar a importância da pesquisa experimental sobre a comunidade zooplanctônica de água doce no Brasil através de uma análise cienciométrica. Métodos As bases de dados Web of Science, SciELO e Scopus foram utilizadas para compilar 249 trabalhos científicos publicados entre 1978 e 2023. Os dados extraídos dos artigos foram o ano de publicação, localização geográfica, características do experimento (tipo, escala, duração), espécies ou táxons estudados e os temas de pesquisa. Sínteses quantitativas e qualitativas foram realizadas para fornecer uma compreensão sistematizada dos estudos experimentais sobre zooplâncton de água doce. Resultados A análise revelou um aumento significativo no número de publicações experimentais ao longo do tempo, com uma maior concentração de estudos na região Sudeste do Brasil. Experimentos de laboratório, principalmente microcosmos foram realizados com mais frequência do que experimentos de campo. Predação, poluentes químicos e eutrofização surgiram como os temas de pesquisa frequentemente abordados. Por outro lado, certos tópicos, como dinâmicas de metapopulação e microplásticos, foram relativamente sub-representados na literatura. Apesar da pesquisa experimental sobre o zooplâncton de água doce no Brasil desempenhar um papel crucial no avanço da compreensão ecológica, há uma distribuição desigual desses estudos pelo país, indicando a necessidade de investimentos e mais pesquisadores preparados para trabalhar com experimentos em certas regiões. Abordar as lacunas identificadas nesta revisão, como dinâmicas de metapopulação e dispersão, juntamente com ameaças emergentes como invasões, microplásticos, patógenos, estressores cumulativos, contaminantes emergentes e nanomateriais, será essencial para gerar conhecimento científico que informe estratégias de manejo eficazes para preservar a biodiversidade do zooplâncton de água doce em meio às mudanças ambientais em curso. Conclusões Esta revisão destaca a importância de expandir a pesquisa experimental por diversas regiões e tópicos pouco explorados para melhorar nossa compreensão ecológica e melhor gerenciar a biodiversidade do zooplâncton de água doce no Brasil. cienciométrica Science 24 197 2023 publicação geográfica tipo, tipo (tipo escala duração, duração , duração) tempo laboratório campo Predação abordados lado microplásticos subrepresentados sub representados literatura país dispersão invasões patógenos cumulativos nanomateriais curso 2 19 202 1 20
Abstract Aim This study aims to contribute to elucidating the importance of experimental research on freshwater zooplankton communities in Brazil through a scientometric analysis. Methods Web of Science, SciELO, and Scopus databases were used to compile 249 scientific papers published between 1978 and 2023. The extracted data included the year of publication, geographical location, experiment characteristics (type, scale, duration), species or taxa studied, and research topics. Quantitative and qualitative syntheses were performed to provide a systematic understanding of experimental studies on freshwater zooplankton. Results The analysis revealed a significant increase in the number of experimental papers over time, with a higher concentration of studies in the Southeastern region of Brazil. Laboratory experiments were conducted with greater frequency than field experiments, mainly microcosms. Predation, chemical pollutants, and eutrophication emerged as frequently addressed research topics. On the other hand, certain topics, such as metapopulation dynamics and microplastics, were relatively underrepresented in the literature. Despite the crucial role of experimental research on freshwater zooplankton in advancing ecological understanding in Brazil, there is an unequal distribution of these studies across the country, indicating the need for investment and more researchers prepared and interested in studying with experiments in certain regions. Addressing the gaps identified in this review, such as metapopulation dynamics and dispersion, along with emerging threats like invasions, microplastics, pathogens, cumulative stressors, emerging contaminants, and nanomaterials, will be essential for generating scientific knowledge to inform effective management strategies to preserve freshwater zooplankton biodiversity amidst ongoing environmental changes. Conclusions This review underscores the importance of expanding experimental research across diverse regions and underexplored topics to enhance our ecological understanding and better manage freshwater zooplankton biodiversity in Brazil. Science SciELO 24 197 2023 publication location type, type (type scale duration, duration , duration) studied time microcosms Predation pollutants hand microplastics literature country dispersion invasions pathogens stressors contaminants nanomaterials changes 2 19 202 1 20
11.
Diretriz de Tomografia Computadorizada e Ressonância Magnética Cardiovascular da Sociedade Brasileira de Cardiologia e do Colégio Brasileiro de Radiologia – 2024 202 20 2
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Magalhães, Tiago Augusto
; Carneiro, Adriano Camargo de Castro
; Moreira, Valéria de Melo
; Trad, Henrique Simão
; Lopes, Marly Maria Uellendahl
; Cerci, Rodrigo Julio
; Nacif, Marcelo Souto
; Schvartzman, Paulo R.
; Chagas, Antônio Carlos Palandrini
; Costa, Isabela Bispo Santos da Silva
; Schmidt, André
; Shiozaki, Afonso Akio
; Montenegro, Sérgio Tavares
; Piegas, Leopoldo Soares
; Zapparoli, Marcelo
; Nicolau, José Carlos
; Fernandes, Fabio
; Hadlich, Marcelo Souza
; Ghorayeb, Nabil
; Mesquita, Evandro Tinoco
; Gonçalves, Luiz Flávio Galvão
; Ramires, Felix José Alvarez
; Fernandes, Juliano de Lara
; Schwartzmann, Pedro Vellosa
; Rassi, Salvador
; Torreão, Jorge Andion
; Mateos, José Carlos Pachón
; Beck-da-Silva, Luiz
; Silva, Marly Conceição
; Liberato, Gabriela
; Oliveira, Gláucia Maria Moraes de
; Feitosa Filho, Gilson Soares
; Carvalho, Hilka dos Santos Moraes de
; Markman Filho, Brivaldo
; Rocha, Ricardo Paulo de Sousa
; Azevedo Filho, Clerio Francisco de
; Taratsoutchi, Flávio
; Coelho-Filho, Otavio Rizzi
; Kalil Filho, Roberto
; Hajjar, Ludhmila Abrahão
; Ishikawa, Walther Yoshiharu
; Melo, Cíntia Acosta
; Jatene, Ieda Biscegli
; Albuquerque, Andrei Skromov de
; Rimkus, Carolina de Medeiros
; Silva, Paulo Savoia Dias da
; Vieira, Thiago Dieb Ristum
; Jatene, Fabio Biscegli
; Azevedo, Guilherme Sant Anna Antunes de
; Santos, Raul D.
; Monte, Guilherme Urpia
; Ramires, José Antonio Franchini
; Bittencourt, Marcio Sommer
; Avezum, Alvaro
; Silva, Leonardo Sara da
; Abizaid, Alexandre
; Gottlieb, Ilan
; Precoma, Dalton Bertolim
; Szarf, Gilberto
; Sousa, Antônio Carlos Sobral
; Pinto, Ibraim Masciarelli Francisco
; Medeiros, Fábio de Morais
; Caramelli, Bruno
; Parga Filho, José Rodrigues
; Santos, Tiago Senra Garcia dos
; Prazeres, Carlos Eduardo Elias dos
; Lopes, Marcelo Antonio Cartaxo Queiroga
; Avila, Luiz Francisco Rodrigues de
; Scanavacca, Mauricio Ibrahim
; Gowdak, Luis Henrique Wolff
; Barberato, Silvio Henrique
; Nomura, Cesar Higa
; Rochitte, Carlos Eduardo
.
12.
Social conditions impact functional outcome in patients with hand osteoarthritis: the low-income hand osteoarthritis (LIHOA) cohort lowincome low income LIHOA (LIHOA
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Azevedo, Francisco Vileimar Andrade de
; Borges, João Pedro Sobreira
; Souza Filho, Antonio Matos de
; Costa Junior, José Carlos Godeiro
; Silveira, Cláudio Régis Sampaio
; Rocha, Francisco Airton Castro
.
Abstract Background Hand osteoarthritis (HOA) is a highly prevalent disease that may be impacted by social inequalities. Few studies in HOA are from underdeveloped regions. We intend to contribute to fill this gap presenting clinical characteristics of our low-income HOA cohort (LIHOA). Methods Data from 119 patients with a HOA diagnosis fulfilling ACR criteria seen between August 2019 and May 2023 in Fortaleza/Brazil. Evaluations included pain (VAS, visual analogue scale), X-ray (KL, Kellgren-Lawrence), grip and pinch strength (KgF), Cochin hand functional scale (CHFS), FIHOA, and SF-12 scores. Social data included monthly (<1, 1≥/<3, ≥3 MW) minimum wage earnings, occupation, and literacy [</≥ 9 school-years (SY)]. Results 107 out of the 119 patients were included. Mean age was 61.9 (±10.3) years with 94 (92%) women. Systemic arterial hypertension (48%), metabolic syndrome (42.8%), dyslipidemia (28.4%), and obesity (25%) were the most common comorbidities. Mean disease duration was 7.5 ± 7.1 years. Median VAS values at rest and activity were 3 (3–5) and 8 (5–9), respectively (p < 0.001). Fifty-seven (56.4%) patients had ≥4 symptomatic joints with a median of 4 (2–8) painful joints at activity. The 2nd distal interphalangeal (IF), joint was the most symptomatic (21; 23.3%) and most had >4 IF nodes. OA in other joints: 37 (36.2%) spine, 28 (29.4%) knee, 21 (20.5%) bunions. Functional impairment was mild [8 (5–14) median FIHOA]. Median serum CRP was 0.2 mg/dL (0.1–0.4) with 14 (20%) patients above reference value. Mean total KL score was 27.6 ± 13.6 with 21 (23%), 38 (41.7%), and 33 (36.2%) KL2, KL3, and KL4, respectively; 51 (54.8%) and 42 (45.2%) patients declared </≥3 MW earnings, respectively. Most declared >9SY including 37.2% with a university degree. Individuals earning <3 MW had lower pinch (p < 0.004) and grip strength (p < 0.01), and higher FIHOA scores (p < 0.007), as compared to ≥3 MW earning group. Literacy or occupation did not impact outcome. SYSADOA were used by 13 (12.7%), 6 used oral and 3 topical anti-inflammatory drugs and 2 used 5 mg/d prednisone. Conclusion Clinical characteristics in our LIHOA cohort mirror those reported in affluent regions. Socioeconomic disparities influenced functional outcome in LIHOA cohort. (HOA inequalities regions lowincome low income LIHOA. . (LIHOA) 11 201 202 FortalezaBrazil Fortaleza Brazil Fortaleza/Brazil VAS, (VAS scale, , scale) Xray X ray KL, (KL KellgrenLawrence, KellgrenLawrence Kellgren Lawrence Kellgren-Lawrence) KgF, KgF (KgF) CHFS, CHFS (CHFS) SF12 SF 12 SF-1 <1, 1 (<1 1≥/<3 ≥ earnings </≥ [</ schoolyears school SY. SY (SY)] 10 619 61 61. ±10.3 103 (±10.3 92% 92 (92% women 48%, 48 48% (48%) 42.8%, 428 42.8% (42.8%) 28.4%, 284 28.4% (28.4%) 25% 25 (25% comorbidities 75 7 7. 71 3–5 35 (3–5 5–9, 59 5–9 (5–9) p 0.001. 0001 0.001 0 001 0.001) Fiftyseven Fifty seven 56.4% 564 56 (56.4% 2–8 (2–8 nd IF, (IF) (21 23.3% 233 23 > nodes 36.2% 362 36 (36.2% spine 29.4% 294 29 (29.4% knee 20.5% 205 20 (20.5% bunions [ 5–14 514 (5–14 FIHOA. FIHOA] 02 0. mgdL mg dL 0.1–0.4 0104 (0.1–0.4 20% (20% value 276 27 27. 136 13. 23%, 23% (23%) 41.7%, 417 41.7% 41 (41.7%) KL2 KL3 KL4 54.8% 548 54 (54.8% 45.2% 452 45 (45.2% 9SY 372 37.2 degree 0.004 0004 004 0.01, 0.01 01 0.01) 0.007, 0007 0.007 007 0.007) group 12.7%, 127 12.7% (12.7%) antiinflammatory anti inflammatory mgd d prednisone (LIHOA Kellgren-Lawrence (KgF (CHFS SF1 SF- <1 (< 1≥/< </ [< (SY) ±10. (±10. (92 (48% 42.8 (42.8% 28.4 (28.4% (25 3– (3– 5– (5–9 000 0.00 00 56.4 (56.4 2– (2– (IF (2 23.3 36.2 (36.2 29.4 (29.4 20.5 (20.5 5–1 (5–1 0.1–0. 010 (0.1–0. (20 (23% 41.7 (41.7% 54.8 (54.8 45.2 (45.2 37. 0.0 12.7 (12.7% ( 1≥/ (SY ±10 (±10 (9 (48 42. (42.8 28. (28.4 (3 (5– 56. (56. 23. 36. (36. 29. (29. 20. (20. 0.1–0 (0.1–0 (23 41. (41.7 54. (54. 45. (45. 12. (12.7 1≥ ±1 (±1 (4 (42. (28. (5 (56 (36 (29 0.1– (0.1– (41. (54 (45 (12. (± (42 (28 0.1 (0.1 (41 (12 (0. (1 (0
13.
Analysis of polio vaccination status in a cohort of live births in 2017 and 2018 in Brazilian cities: a national vaccination coverage survey 201 cities 20 2
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Franco, Alessandra Lucchesi de Menezes Xavier
; França, Ana Paula
; Moraes, José Cássio de
; Ribeiro, Manoel Carlos Sampaio de Almeida
; Silva, Adriana Ilha da
; Ramos Jr., Alberto Novaes
; França, Ana Paula
; Oliveira, Andrea de Nazaré Marvão
; Boing, Antonio Fernando
; Domingues, Carla Magda Allan Santos
; Oliveira, Consuelo Silva de
; Maciel, Ethel Leonor Noia
; Guibu, Ione Aquemi
; Mirabal, Isabelle Ribeiro Barbosa
; Barbosa, Jaqueline Caracas
; Lima, Jaqueline Costa
; Moraes, José Cássio de
; Luhm, Karin Regina
; Caetano, Karlla Antonieta Amorim
; Lima, Luisa Helena de Oliveira
; Antunes, Maria Bernadete de Cerqueira
; Teixeira, Maria da Gloria
; Teixeira, Maria Denise de Castro
; Borges, Maria Fernanda de Sousa Oliveira
; Queiroz, Rejane Christine de Sousa
; Gurgel, Ricardo Queiroz
; Barata, Rita Barradas
; Azevedo, Roberta Nogueira Calandrini de
; Oliveira, Sandra Maria do Valle Leone de
; Teles, Sheila Araújo
; Gama, Silvana Granado Nogueira da
; Mengue, Sotero Serrate
; Simões, Taynãna César
; Nascimento, Valdir
; Araújo, Wildo Navegantes de
.
RESUMO Objetivo Descrever a situação vacinal contra poliomielite em 26 capitais, Distrito Federal e 12 municípios do Brasil, em crianças nascidas em 2017 e 2018. Métodos Inquérito domiciliar de base populacional realizado de 2020 a 2022, em que se avaliou a cobertura vacinal da poliomielite em crianças, considerando doses válidas, aplicadas e oportunas por municípios. Resultados Foram coletados dados de 37.801 crianças. A cobertura vacinal de esquema completo de doses válidas foi de 87,5% (IC95% 86,2;88,7), caindo para 79,6% (IC95% 78,1;81,0), considerando a dose de reforço. A taxa de abandono foi de 4,5% para esquema completo, e de 11,7% no primeiro reforço. Não houve correlação entre a realização de campanha e as elevadas coberturas. Conclusão A cobertura vacinal de esquema completo e no primeiro reforço não atingiu a meta de 95,0%. Diferenças regionais e a associação das coberturas vacinais com indicadores sociais devem ser consideradas nas estratégias de aumento da cobertura. 2 capitais 1 Brasil 201 2018 202 2022 37801 37 801 37.80 875 87 5 87,5 IC95% IC95 IC (IC95 86,288,7, 862887 86,2 88,7 , 86 88 7 86,2;88,7) 796 79 6 79,6 78,181,0, 781810 78,1 81,0 78 81 0 78,1;81,0) 45 4 4,5 117 11 11,7 950 95 95,0% 20 3780 3 80 37.8 8 87, IC9 (IC9 288 86,288,7 86288 862 86, 887 88, 86,2;88,7 79, 181 78,181,0 78181 781 78, 810 81, 78,1;81,0 4, 11, 9 95,0 378 37. (IC 28 86,288, 8628 86,2;88, 18 78,181, 7818 78,1;81, 95, 86,288 86,2;88 78,181 78,1;81 86,28 86,2;8 78,18 78,1;8 86,2; 78,1;
ABSTRACT Objective To describe the polio vaccination status in 26 state capitals, the Federal District, and 12 municipalities in Brazil, among children born between 2017 and 2018. Methods This was a population-based household survey conducted from 2020 to 2022, which assessed polio vaccination coverage in children, considering valid, administered, and timely doses by municipality. Results Data were collected from 37,801 children. Vaccination coverage for the complete valid dose schedule was 87.5% (95%CI 86.2;88.7), dropping to 79.6% (95%CI 78.1;81.0), when the booster dose was considered. The dropout rate was 4.5% for the complete schedule, and 11.7% for the first booster. There was no correlation between campaign implementation and high coverage. Conclusion Vaccination coverage for the complete valid dose schedule and the first booster did not meet the 95.0% target. Regional disparities and the association between vaccination coverage and social indicators should be taken into consideration in strategies to increase coverage. 2 capitals District 1 Brazil 201 2018 populationbased population based 202 2022 administered municipality 37801 37 801 37,80 875 87 5 87.5 95%CI 95CI CI 95 86.288.7, 862887 86.2 88.7 , 86 88 7 86.2;88.7) 796 79 6 79.6 78.181.0, 781810 78.1 81.0 78 81 0 78.1;81.0) considered 45 4 4.5 117 11 11.7 950 95.0 target 20 3780 3 80 37,8 8 87. 9 288 86.288.7 86288 862 86. 887 88. 86.2;88.7 79. 181 78.181.0 78181 781 78. 810 81. 78.1;81.0 4. 11. 95. 378 37, 28 86.288. 8628 86.2;88. 18 78.181. 7818 78.1;81. 86.288 86.2;88 78.181 78.1;81 86.28 86.2;8 78.18 78.1;8 86.2; 78.1;
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14.
Cardiovascular rhythmicity in overweight and obese children
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Pinto-Silva, Catarina
; Correia-Costa, Ana
; Moura, Cláudia
; Mota, Cláudia
; Guerra, António
; Areias, José Carlos
; Schaefer, Franz
; Afonso, Alberto Caldas
; Wühl, Elke
; Azevedo, Ana
; Correia-Costa, Liane
.
Resumo Introdução: Acredita-se que a obesidade desempenhe um papel na desregulação da ritmicidade cardíaca em crianças obesas, mas esse é um campo de investigação ainda pouco explorado. O objetivo deste trabalho foi avaliar o impacto do sobrepeso e da obesidade na ritmicidade cardiovascular circadiana e ultradiana de crianças pré-púberes, em comparação com crianças com peso normal. Métodos: Realizamos um estudo transversal com 316 crianças, acompanhadas na coorte de nascimentos Geração XXI (Portugal). Foram medidos dados antropométricos e a pressão arterial ambulatorial de 24 horas, e os perfis foram examinados com uma análise de Fourier para ritmos circadianos e ultradianos de pressão arterial (PA) e frequência cardíaca (FC). Resultados: Crianças com sobrepeso/obesidade apresentaram mais frequentemente um padrão de PA não-dipper em comparação com crianças com peso normal (31,5% vs. 21,6%; p = 0,047). A prevalência da pressão arterial média (PAM) de 24 horas e da ritmicidade da FC de 8 horas foi significativamente menor em crianças obesas (79,3% vs. 88,0%; p = 0,038 e 33,3% vs. 45,2%; p = 0,031, respectivamente). A prevalência das restantes ritmicidades da PAM e da FC foi semelhante em ambos os grupos. Não foram encontradas diferenças nos valores medianos das amplitudes e acrofases dos ritmos de PAM e FC. Discussão: As alterações encontradas na ritmicidade sugerem que a análise da ritmicidade circadiana e ultradiana pode ser sensível na detecção de desregulações cardiovasculares precoces, mas são necessários novos estudos para reforçar nossos achados e entender melhor suas implicações a longo prazo. Introdução Acreditase Acredita se explorado prépúberes, prépúberes pré púberes, púberes pré-púberes Métodos 31 Portugal. Portugal . (Portugal) 2 (PA (FC) Resultados sobrepesoobesidade nãodipper não dipper 31,5% 315 5 (31,5 vs 21,6% 216 21 6 0,047. 0047 0,047 0 047 0,047) (PAM 79,3% 793 79 3 (79,3 88,0% 880 88 0038 038 0,03 333 33 33,3 45,2% 452 45 0031 031 0,031 respectivamente. respectivamente respectivamente) grupos Discussão precoces prazo (Portugal (FC 31,5 (31, 21,6 004 0,04 04 79,3 7 (79, 88,0 003 03 0,0 33, 45,2 4 31, (31 21, 00 79, (79 88, 0, 45, (3 (7 (
Abstract Introduction: Obesity is thought to play a role in the disruption of cardiac rhythmicity in obese children, but this is mostly an unexplored field of investigation. We aimed to evaluate the impact of overweight and obesity on circadian and ultradian cardiovascular rhythmicity of prepubertal children, in comparison with normal weight counterparts. Methods: We performed a cross sectional study of 316 children, followed in the birth cohort Generation XXI (Portugal). Anthropometrics and 24-hour ambulatory blood pressure were measured and profiles were examined with Fourier analysis for circadian and ultradian blood pressure (BP) and heart rate (HR) rhythms. Results: Overweight/obese children presented more frequently a non-dipping BP pattern than normal weight counterparts (31.5% vs. 21.6%, p = 0.047). The prevalence of 24-hour mean arterial pressure (MAP) and 8-hour HR rhythmicity was significantly lower in obese children (79.3% vs. 88.0%, p = 0.038 and 33.3% vs. 45.2%, p = 0.031, respectively). The prevalence of the remaining MAP and HR rhythmicity was similar in both groups. No differences were found in the median values of amplitudes and acrophases of MAP and HR rhythms. Discussion: The alterations found in rhythmicity suggest that circadian and ultradian rhythmicity analysis might be sensitive in detecting early cardiovascular dysregulations, but future studies are needed to reinforce our findings and to better understand their long-term implications. Introduction investigation Methods 31 Portugal. Portugal . (Portugal) 24hour hour 24 (BP (HR rhythms Results Overweightobese Overweight nondipping non dipping 31.5% 315 5 (31.5 vs 216 21 6 21.6% 0.047. 0047 0.047 0 047 0.047) (MAP 8hour 8 79.3% 793 79 3 (79.3 880 88 88.0% 0038 038 0.03 333 33 33.3 452 45 2 45.2% 0031 031 0.031 respectively. respectively respectively) groups Discussion dysregulations longterm long term implications (Portugal 31.5 (31. 21.6 004 0.04 04 79.3 7 (79. 88.0 003 03 0.0 33. 4 45.2 31. (31 21. 00 79. (79 88. 0. 45. (3 (7 (
15.
Updating knowledge in estimating the genetics parameters: Multi-trait and Multi-Environment Bayesian analysis in rice
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Azevedo, Camila Ferreira
; Barreto, Cynthia Aparecida Valiati
; Suela, Matheus Massariol
; Nascimento, Moysés
; Silva Júnior, Antônio Carlos da
; Nascimento, Ana Carolina Campana
; Cruz, Cosme Damião
; Soraes, Plínio César
.
ABSTRACT Among the multi-trait models selected to study several traits and environments jointly, the Bayesian framework has been a preferred tool when constructing a more complex and biologically realistic model. In most cases, non-informative prior distributions are adopted in studies using the Bayesian approach. However, the Bayesian approach presents more accurate estimates when informative prior distributions are used. The present study was developed to evaluate the efficiency and applicability of multi-trait multi-environment (MTME) models within a Bayesian framework utilizing a strategy for eliciting informative prior distribution using previous data on rice. The study involved data pertaining to rice (Oryza sativa L.) genotypes in three environments and five crop seasons (2010/2011 until 2014/2015) for the following traits: grain yield (GY), flowering in days (FLOR) and plant height (PH). Variance components, genetic and non-genetic parameters were estimated using the Bayesian method. In general, the informative prior distribution in Bayesian MTME models provided higher estimates of individual narrow-sense heritability and variance components, as well as minor lengths for the highest probability density interval (HPD), compared to their respective non-informative prior distribution analyses. More informative prior distributions make it possible to detect genetic correlations between traits, which cannot be achieved with non-informative prior distributions. Therefore, this mechanism presented to update knowledge for an elicitation of an informative prior distribution can be efficiently applied in rice breeding programs.
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