Pesquisa | SciELO

Abstract To identify this increasingly common pathology, known as Multiple Myeloma, it is necessary to refer to the specific factors that characterize it; to this end, the classic criteria known as CRAB (hypercalcemia, renal failure, anemia and lytic lesions) are available, in which renal failure is one of the most frequent complications. Recently, 3 indisputable biomarkers have been described for the diagnostic support for Multiple Myeloma, which are: more than 10% of clonal plasma cells in BM or, a biopsy that corroborates the presence of a plasmacytoma, light chain ratio ≥100 mg/dL and more than one focal lesion on magnetic resonance imaging (MRI). A differential diagnosis for plasma cell leukemia, solitary bone plasmacytoma, and extramedullary plasmacytoma should always be considered. Being this an incurable disease, a lot of research has been done regarding its therapeutic management, whose main objective is the disappearance of plasma cells and the patient clinical improvement. Melphalan was the first drug that showed a benefit in 1958 and afterwards, with the addition of a steroid as a second drug, it was possible to improve response rates. Subsequently, different molecules were studied, forming multiple combinations, and achieving better rates of Overall Survival and Progression-Free Survival. Years later, with the arrival of proteasome inhibitors such as bortezomib, and immunomodulators such as thalidomide and lenalidomide, an important turnaround in the disease has been seen, as deeper responses, more prolonged remissions, and improvement in the quality of life of patients have been achieved. This consensus has the purpose of integrating a group of Mexican specialists and promoting the updating of this pathology.

ABSTRACT While progressive governments are in transition in the region, in Ecuador the progressive government will continue. It is important to review some key aspects of the Ecuadorean context and its relation with the development model as a reflection of capital accumulation. This essay analyses Good Living/Sumak Kawsay as a civilization alternative and reviews National Development plans. Even though another way of living was proposed, little transformation was actually achieved; looking ten years back, we have a modern Ecuadorean state, a more humane capitalism. Despite Sumak Kawsay currently being empty of content, we suggest it is worthwhile to recover that dimension.

RESUMEN Con la transición de gobiernos progresistas en la región mientras en Ecuador se mantiene el progresismo, vale recordar algunos hitos del contexto ecuatoriano y la disputa por la acumulación del capital reflejada en el modelo de desarrollo. Este ensayo analiza el Buen Vivir/Sumak Kawsay como alternativa civilizatoria y aborda los planes nacionales de desarrollo. A pesar de que en un inicio se planteó otro modo civilizatorio, con el paso de los años poco se logró concretar de cambio y transformación; una mirada a la década anterior nos deja de saldo un Estado Ecuatoriano moderno, capitalismo con rostro humano. A pesar del vaciamiento del concepto, vale la pena seguir disputando esa dimensión.

Cód. do Índice	Elemento
ti	título do artigo
au	autor
kw	palavras-chave do artigo
subject	assunto (palavras do título, resumo e palavras-chave)
ab	resumo
ta	título abreviado da revista (ex. Cad. Saúde Pública)
journal_title	título completo da revista (ex. Cadernos de Saúde Pública)
la	código do idioma da publicação (ex. pt - Português, es - Espanhol)
type	tipo do documento
pid	identificador da publicação
publication_year	ano de publicação do artigo
sponsor	financiador
aff_country	código do país de afiliação do autor
aff_institution	instituição de afiliação do autor
volume	volume do artigo
issue	número do artigo
elocation	elocation
doi	número DOI
issn	ISSN da revista
in	código da coleção SciELO (ex. scl - Brasil, col - Colômbia)
use_license	código da licença de uso do artigo

Não foram encontrados documentos para sua pesquisa