Abstract Introduction Permanent education in health aims to ensure that professionals are constantly learning in the workplace and in the last few years institutions resorted to the technology-mediated education modality and new teaching possibilities were explored. In Brazil, between 2017 and 2021, only six articles and five monographs were published about listening effort. Objective The objective of this study was to develop a website with scientific content on the topic listening effort for Speech -Language Therapist and Audiologist with free online access. Methods The study was carried out in five stages: Analysis, contemplating the search for scientific materials to prepare the material. Design, in which the writing and design of the website was carried out. Development, carrying out the adequacy of the online material. Implementation, a stage in which professionals in the area evaluated the quality of the material after consenting to participation through a free and informed consent term. Review, stage in which the researcher analyzed the evaluators' responses. Results The five stages of elaboration of the website were carried out, which was evaluated by professionals in the area. The average of responses to all applied questions rated the website as "superior". Conclusion The website development was validated for online availability. technologymediated technology mediated explored Brazil 201 2021 Language access Analysis Design Development Implementation term Review evaluators superior. superior . "superior" availability 20 202 "superior 2

Abstract To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety. date disease reallife real life attacks vasoocclusive vaso occlusive events syndrome transfusion which part physicians physician s report safety

ABSTRACT. In soybeans, the integument or seed coat is an important modulator between the external and internal environment. It plays a fundamental role in seed vitality, and its lignin content may influence the seed quality. The objective of this experiment was to evaluate the quality of soybean seeds from a partial diallel and their reciprocals and its relationship with lignin content, seed coat thickness, and deposition location. The seeds were also evaluated for physiological quality through germination and accelerated aging tests. The lignin content was quantified by absorbance, and the integument thickness was analyzed and measured using scanning electron microscopy. The most contrasting cultivars for lignin content were analyzed using fluorescence microscopy and histochemical techniques. Cultivars and their reciprocals differed in seed physiological quality. We found differences in the genotypes for integument thickness. Using histochemical techniques, autofluorescence was observed in the same regions identified as lignified. Positive staining for lignin was observed in the hilum region. Among the genotypes, we found variations in the physiological quality of seeds (germination and accelerated aging test), lignin content, and integument thickness. ABSTRACT soybeans environment vitality location tests absorbance techniques lignified region test, test , test)

RESUMO Objetivo comparar as respostas de adultos e idosos com perda auditiva de grau leve no inventário de restrição de participação e relacionar o grau de restrição com a perda auditiva em altas frequências, bem como avaliar se há diferença entre as respostas de homens e mulheres em relação à restrição de participação. Métodos a amostra foi composta por 38 adultos e idosos, com média de 67 anos de idade, de ambos os gêneros, matriculados em um serviço de saúde auditiva. Foi realizada audiometria de altas frequências e foram aplicados os questionários Hearing Handicap Inventory for Adults ou Hearing Handicap Inventory for Elderly. Os estudos estatísticos aplicados foram o teste de Mann-Whitney, análise de variância unidirecional e teste Qui-Quadrado. Resultados foram encontradas diferenças significativas entre os grupos de idosos e adultos em relação ao grau de restrição de participação, mas não foram encontradas correlações entre a audiometria de altas frequências e o grau de restrição de participação. Ainda, foi possível observar que as mulheres apresentaram maior grau de restrição de participação que os homens. Conclusão adultos apresentam maiores índices de percepção de restrição de participação quando comparados com idosos e há diferença entre a percepção do handicap conforme o gênero, porém, os resultados dos questionários não estão relacionados com a perda auditiva em altas frequências na população estudada. 3 6 idade gêneros Elderly MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney QuiQuadrado. QuiQuadrado Qui Quadrado. Quadrado Qui-Quadrado Ainda gênero porém estudada

ABSTRACT Purpose to compare the responses of adults and elderly people with mild hearing loss in the participation restriction inventory and relate the degree of restriction with hearing loss at high frequencies, as well as to evaluate whether there is a difference between the responses of men and women in relation to participation restrictions. Methods the sample of 38 participants was made up of adults and elderly people with an average of 67 years of age, of both sexes, enrolled in a hearing health service. High Frequency Audiometry was performed and the Hearing Handicap Inventory for Adults or Hearing Handicap Inventory for Elderly questionnaires were administered. The statistical study applied to the data was the Mann-Whitney test, oneway analysis of variance and Chi-Square. Results significant differences were found between the elderly and adult groups in relation to the degree of participation restriction, but no correlations were found between high frequency audiometry and the degree of participation restriction. It was also possible to observe that women have a greater degree of participation restriction than men. Conclusion adults have higher rates of perception of participation restrictions when compared to the elderly and there is a difference between the perception of handicap according to gender, but the results of the questionnaires are not related to hearing loss in high frequencies in this population. 3 6 age sexes service administered MannWhitney Mann Whitney test ChiSquare. ChiSquare Chi Square. Square Chi-Square gender population

ABSTRACT Two experiments were conducted to assess the impact of an enzyme complex (EC) on the metabolizability coefficients of dry matter (MCDM), crude protein (MCCP), and ether extract (MCEE) and on the nitrogen-corrected apparent metabolizable energy (AMEn) of corn gluten meal, soybean protein concentrate, dried bovine plasma, and poultry offal meal. Additionally, the experiments aimed to evaluate how EC affected broiler performance. In experiment I, 720 day-old Cobb 500® broilers were assigned to a completely randomized design using a 4 × 2 factorial arrangement. The main factors considered were the feedstuff (corn gluten meal, soybean protein concentrate, dried bovine plasma, and poultry offal meal) and the presence or absence of EC. The broilers were housed in 45 pens, using five replicates, with ten birds in the pre-starter phase and six birds in the starter phase. This design resulted in eight treatment groups, including one reference diet group. In experiment II, 1140 day-old Cobb 500® chicks were allotted in a completely randomized design, employing a 4 × 2 factorial arrangement, with the same main factors as in experiment I. Birds were housed in 48 pens, using six replicates/30 birds, yielding eight treatments. The use of the EC did not lead to improvements in digestibility of the feedstuffs. However, the addition of EC resulted in enhanced body weight gain and improved feed conversion ratios across all phases of broiler growth. Enzyme complex inclusion did not affect feed intake. While the EC did not enhance the metabolizability of nutrients in feedstuffs individually, broilers fed diets containing these feedstuffs and supplemented with EC exhibited improved performance at 42 days of age. This suggests that the impact of the EC varies depending on whether it is observed at the feedstuff or diet level. (EC MCDM, MCDM , (MCDM) MCCP, MCCP (MCCP) MCEE (MCEE nitrogencorrected nitrogen corrected AMEn (AMEn meal concentrate plasma Additionally I 72 dayold day old 500 arrangement pens replicates prestarter pre groups group II 114 replicates30 30 replicates/3 treatments However growth intake individually age level (MCDM (MCCP 7 50 11 replicates3 3 replicates/ 5 1

Resumo O objetivo do presente trabalho foi avaliar alternativas para a modelagem hipsométrica generalista de eucalipto via regressão linear, com a inclusão de índices de competição independentes da distância como variável preditora. Os dados utilizados foram provenientes de 34 parcelas distribuídas em quatro unidades de manejo florestal com 72 meses de idade. Calcularam-se 7 índices de competição independentes da distância. Avaliou-se o desempenho preditivo de 16 modelos hipsométricos generalistas, sendo propostos 14 modelos de dupla entrada (DAP e índice de competição). Todas as equações geradas foram biologicamente consistentes. Diante da ausência de informações da altura de árvores dominantes, a modelagem generalista pode ser melhor viabilizada com a inclusão do índice IC4, que representa a área basal de árvores vizinhas competidoras. Conclui-se que a inclusão de índices de competição em modelos hipsométricos ampliam a capacidade de generalização de equações para talhões de eucalipto com distintas capacidades produtivas. O índice de competição IC4 favorece a qualidade de ajuste e desempenho preditivo da modelagem hipsométrica nos sítios estudados.

Abstract This study aimed to evaluate alternatives for general hypsometric modeling of eucalypt through linear regression, with inclusion of distance-independent competition indices as a predictor variable. The data was collected from 34 plots distributed in four 72-month-old forest management units. Seven distance-independent competition indices were calculated. The study evaluated the predictive performance of 16 general hypsometric models, and 14 double-entry models (DAP and competition index) were proposed. All equations generated were biologically consistent. Given the lack of information on the height of dominant trees, general modeling can be better employed with inclusion of the IC4 index, which represents basal area of neighboring competing trees. It is concluded that the inclusion of competition indices in hypsometric models increases generalization capacity of equations for eucalyptus stands with different productive capacities. The IC4 competition index enhances fit quality and predictive performance of the hypsometric modeling in the study sites.

ABSTRACT Objective: To translate, cross-culturally adapt and validate the Sickle Cell Self-Efficacy Scale for application in the Brazilian cultural context. Methods: This is a methodological study performed in 6 steps: 1- Forward translation; 2- Translation synthesis; 3- Back-translation; 4- Assessment by expert committee, with computation of the Content Validity Index (CVI); 5- Cultural adequacy (pre-test); 6- Reproducibility. A pre-test was performed with the participation of 10 adolescents/young adults with sickle cell disease through a telephone call and their responses were recorded on a form in a web platform. The instrument validation step was carried out with 55 adolescents/young adults with sickle cell disease, 43 of them having participated in the retest. The analysis of internal consistency and reproducibility was calculated using the Cronbach’s alpha coefficient and the Intraclass Correlation Coefficient (ICC), in the R statistical programming environment. Results: The translated instrument had good acceptance among the experts, reaching an average CVI of 1.0. In assessing reliability, the scale showed acceptable internal consistency, with a Cronbach’s alpha of 0.84. In the agreement analysis, the ICC was 0.923 (95% CI: 0.857 to 0.958), which indicates good temporal reproducibility. Conclusions: Following the process of translation, cross-cultural adaptation and validation, we obtained the Brazilian version of the Sickle Cell Self-Efficacy Scale, considered valid and reliable to be applied to adolescents and young adults with sickle cell disease in Brazil. Objective translate crossculturally cross culturally SelfEfficacy Self Efficacy context Methods steps 1 translation 2 synthesis 3 Backtranslation Back Back-translation 4 committee (CVI) 5 pretest pre test (pre-test) Reproducibility adolescentsyoung platform retest Cronbachs Cronbach s ICC, , (ICC) environment Results experts 0 1.0 reliability 084 84 0.84 0923 923 0.92 95% 95 (95 CI 0857 857 0.85 0.958, 0958 0.958 958 0.958) Conclusions crosscultural Brazil (CVI (pre-test (ICC 1. 08 8 0.8 092 92 0.9 9 (9 085 85 095 0.95 0. 09 (

Resumen Objetivo Analizar la calidad de vida de los cuidadores familiares de pacientes en hemodiálisis y la existencia de asociación con las características demográficas y clínicas. Métodos Estudio transversal, realizado con 75 cuidadores familiares en dos centros de diálisis. La calidad de vida de los cuidadores fue medida a través del instrumento World Health Organization Quality of Life – BREF, y su relación con las características sociodemográficas fue evaluada mediante la prueba de Kruskal-Wallis (nivel de significación igual a 5 %). Resultados La mayoría de los cuidadores familiares era mujer (84 %), cónyuge (41,3 %), hijo (38,7 %), del hogar (38,7 %) y poseía ingresos familiares de uno a tres salarios mínimos (85,4 %). La variable trabajar fuera de casa tuvo influencia positiva en la calidad de vida general (p=0,014), en los dominios psicológicos (p=0,009) y en las relaciones sociales (p≤0,001). Ser de sexo masculino (p=0,016), no tener enfermedades (p=0,002) y no usar medicamentos (p=0,007) interfirieron positivamente en el dominio físico. La ausencia de ayuda financiera de otras personas o familiares influyó de manera negativa en los dominios de las relaciones sociales (p=0,050) y del medio ambiente (p=0,001). Conclusión Los cuidadores familiares de sexo masculino, o que trabajan fuera de casa o reciben ayuda financiera de otras personas o familiares presentaron mejores niveles de calidad de vida. En contraste, las condiciones clínicas, tales como hacer uso de algún medicamento o padecer enfermedades, influyeron de forma negativa en los niveles de calidad de vida. clínicas transversal 7 diálisis BREF KruskalWallis Kruskal Wallis nivel %. % . 84 (8 %, , 41,3 413 41 3 (41, 38,7 387 38 (38, 85,4 854 85 4 (85, p=0,014, p0014 p p=0,014 0 014 (p=0,014) p=0,009 p0009 009 (p=0,009 p≤0,001. p0001 p≤0,001 001 (p≤0,001) p=0,016, p0016 p=0,016 016 (p=0,016) p=0,002 p0002 002 (p=0,002 p=0,007 p0007 007 (p=0,007 físico p=0,050 p0050 050 (p=0,050 p=0,001. p=0,001 (p=0,001) contraste 8 ( 41, (41 38, (38 85, (85 p001 p=0,01 01 (p=0,014 p=0,00 p000 00 (p=0,00 p≤0,00 (p≤0,001 (p=0,016 p=0,05 p005 05 (p=0,05 (p=0,001 (4 (3 p00 p=0,0 (p=0,01 (p=0,0 p≤0,0 (p≤0,00 p0 p=0, (p=0, p≤0, (p≤0,0 p=0 (p=0 p≤0 (p≤0, p= (p= p≤ (p≤0 (p (p≤

Abstract Objective To analyze the quality of life of family caregivers of patients under hemodialysis and the existence of an association with their sociodemographic and clinics characteristics. Methods This is a cross-sectional study conducted with 75 family caregivers in two hemodialysis centers. Caregivers’ quality of life was measured using the World Health Organization Quality of Life – BREF instrument, and its association with sociodemographic characteristics was assessed using the Kruskal-Wallis test (significance level equal to 5%). Results Most family caregivers were women (84%), spouses (41.3%), children (38.7%), housewives (38.7%) and had a family income of one to three minimum wages (85.4 %). The variable working outside the home had a positive influence on overall quality of life (p=0.014), psychological domains (p=0.009) and social relationships (p≤0.001). Being male (p=0.016), not having diseases (p=0.002) and not using medications (p=0.007) positively interfered with the physical domain. The absence of financial help from other people and/or family members had a negative influence on the social relationships (p=0.050) and environment (p=0.001) domains. Conclusion Male family caregivers, or those who work outside the home or receive financial help from other people and/or family members had better quality of life levels. On the other hand, clinical conditions such as using a drug or having diseases have negatively influenced quality of life levels. crosssectional cross sectional 7 centers Caregivers instrument KruskalWallis Kruskal Wallis significance 5%. 5 5% . 5%) 84%, 84 84% , (84%) 41.3%, 413 41.3% 41 3 (41.3%) 38.7%, 387 38.7% 38 (38.7% 85.4 854 85 4 (85. %. % %) p=0.014, p0014 p p=0.014 0 014 (p=0.014) p=0.009 p0009 009 (p=0.009 p≤0.001. p0001 p≤0.001 001 (p≤0.001) p=0.016, p0016 p=0.016 016 (p=0.016) p=0.002 p0002 002 (p=0.002 p=0.007 p0007 007 (p=0.007 domain andor p=0.050 p0050 050 (p=0.050 p=0.001 (p=0.001 levels hand 8 (84% 41.3 (41.3% 38.7 (38.7 85. (85 p001 p=0.01 01 (p=0.014 p=0.00 p000 00 (p=0.00 p≤0.00 (p≤0.001 (p=0.016 p=0.05 p005 05 (p=0.05 (84 41. (41.3 38. (38. (8 p00 p=0.0 (p=0.01 (p=0.0 p≤0.0 (p≤0.00 (41. (38 ( p0 p=0. (p=0. p≤0. (p≤0.0 (41 (3 p=0 (p=0 p≤0 (p≤0. (4 p= (p= p≤ (p≤0 (p (p≤

Resumo Objetivo Analisar a qualidade de vida do cuidador familiar do paciente em hemodiálise e a existência de associação com suas características clínicas e sociodemográficas. Métodos Estudo transversal, realizado com 75 cuidadores familiares em dois centros de diálise. A qualidade de vida do cuidador foi medida por meio do instrumento World Health Organization Quality of Life – BREF, e sua associação com as características sociodemográficas foi avaliada pelo teste de Kruskal-Wallis (nível de significância igual a 5%). Resultados A maioria dos cuidadores familiares era mulher (84%), cônjuge (41,3%), filho (38,7%), do lar (38,7%) e possuía renda familiar de um a três salários mínimos (85,4%). A variável trabalhar fora de casa teve influência positiva na qualidade de vida geral (p=0,014), nos domínios psicológicos (p=0,009) e nas relações sociais (p≤0,001). Ser do sexo masculino (p=0,016), não ter doenças (p=0,002) e não usar medicamentos (p=0,007) interferiram positivamente no domínio físico. A ausência de ajuda financeira de outras pessoas e/ou familiares influenciou de forma negativa nos domínios das relações sociais (p=0,050) e meio ambiente (p=0,001). Conclusão O cuidador familiar do sexo masculino, ou que trabalha fora de casa ou recebe ajuda financeira de outras pessoas e/ou familiares apresentaram melhores níveis de qualidade de vida. Em contrapartida, as condições clínicas tais como fazer uso de algum medicamento ou ter doenças influenciaram de forma negativa nos níveis de qualidade de vida. transversal 7 diálise BREF KruskalWallis Kruskal Wallis nível 5%. 5 5% . 5%) 84%, 84 84% , (84%) 41,3%, 413 41,3% 41 3 (41,3%) 38,7%, 387 38,7% 38 (38,7% 85,4%. 854 85,4% 85 4 (85,4%) p=0,014, p0014 p p=0,014 0 014 (p=0,014) p=0,009 p0009 009 (p=0,009 p≤0,001. p0001 p≤0,001 001 (p≤0,001) p=0,016, p0016 p=0,016 016 (p=0,016) p=0,002 p0002 002 (p=0,002 p=0,007 p0007 007 (p=0,007 físico eou p=0,050 p0050 050 (p=0,050 p=0,001. p=0,001 (p=0,001) contrapartida 8 (84% 41,3 (41,3% 38,7 (38,7 85,4 (85,4% p001 p=0,01 01 (p=0,014 p=0,00 p000 00 (p=0,00 p≤0,00 (p≤0,001 (p=0,016 p=0,05 p005 05 (p=0,05 (p=0,001 (84 41, (41,3 38, (38, 85, (85,4 p00 p=0,0 (p=0,01 (p=0,0 p≤0,0 (p≤0,00 (8 (41, (38 (85, p0 p=0, (p=0, p≤0, (p≤0,0 ( (41 (3 (85 p=0 (p=0 p≤0 (p≤0, (4 p= (p= p≤ (p≤0 (p (p≤

SUMMARY OBJECTIVE: The aim of the present study was to evaluate the outcomes of cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt. METHODS: A retrospective longitudinal observational study was carried out evaluating 38 cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt. The outcomes were evaluated in an outpatient follow-up period of 3 months. The assumed significance level was 5%. RESULTS: The indications for transjugular intrahepatic portosystemic shunt were refractory ascites in 21 (55.3%), variceal hemorrhage in 13 (34.2%), and hydrothorax in 4 (10.5%) patients. There was development of hepatic encephalopathy in 10 (35.7%) patients after transjugular intrahepatic portosystemic shunt. From the 21 patients with refractory ascites, resolution was observed in 1 (3.1%) patient, and in 16 (50.0%) patients, there was ascites control. Regarding transjugular intrahepatic portosystemic shunt after variceal bleeding, 10 (76.9%) patients remained without new bleeding or hospitalizations in the follow-up period. The global survival in the follow-up period in patients with and without hepatic encephalopathy was 60 vs. 82%, respectively (p=0.032). CONCLUSION: Transjugular intrahepatic portosystemic shunt can be considered in decompensated cirrhotic patients; however, the development of hepatic encephalopathy which can shorten survival should be focused. OBJECTIVE METHODS followup follow up months 5 5% RESULTS 2 55.3%, 553 55.3% , 55 (55.3%) 34.2%, 342 34.2% 34 (34.2%) 10.5% 105 (10.5% 35.7% 357 35 7 (35.7% 3.1% 31 (3.1% patient 50.0% 500 50 0 (50.0% control 76.9% 769 76 9 (76.9% 6 vs 82 82% p=0.032. p0032 p p=0.032 . 032 (p=0.032) CONCLUSION however focused 55.3 (55.3% 34.2 (34.2% 10.5 (10.5 35.7 (35.7 3.1 (3.1 50.0 (50.0 76.9 (76.9 8 p003 p=0.03 03 (p=0.032 55. (55.3 34. (34.2 10. (10. 35. (35. 3. (3. 50. (50. 76. (76. p00 p=0.0 (p=0.03 (55. (34. (10 (35 (3 (50 (76 p0 p=0. (p=0.0 (55 (34 (1 ( (5 (7 p=0 (p=0. p= (p=0 (p= (p

Abstract The study describes the occurrence of cysticercosis in liver of 22 wild agoutis (Dasyprocta leporina) in the Brazilian Amazon. The phylogenetic analysis and microscopic characteristics of metacestodes in liver tissue sections, associated with the geographic distribution of the intermediate hosts indicated that a possibly novel Taenia sp. metacestode caused the parasitism. Additionally, two cases of hepatic co-infection by Taenia sp., Calodium sp. and Echinococcus oligarthra were also observed among the analyzed animals. The results point to the need for a better understanding of hepatotropic parasites among wild rodents in the Brazilian Amazon. 2 Dasyprocta leporina Amazon sections sp parasitism Additionally coinfection co infection animals

Resumo O estudo descreve a ocorrência de cisticercose no fígado de 22 cutias (Dasyprocta leporina) silvestres da Amazônia brasileira. A análise filogenética e as características microscópicas dos metacestódeos em cortes histológicos de fígado, associadas à distribuição geográfica do hospedeiro intermediário, indicaram que, possivelmente, uma nova espécie de Taenia sp. Causou o parasitismo. Adicionalmente, dois casos de co-infecção por Taenia sp., Calodium sp. e Echinococcus oligarthra também foram observados entre os animais avaliados. Os resultados apontam para a necessidade de um melhor entendimento dos parasitas hepatotrópicos entre roedores selvagens da Amazônia brasileira. 2 Dasyprocta leporina brasileira intermediário que possivelmente sp parasitismo Adicionalmente coinfecção co infecção avaliados

ABSTRACT The objective of this study was to evaluate whether the addition of the enzymes phytase and xylanase, isolated or associated, in the liquid form after feed pelletization could improve energy utilization and digestibility of calcium and phosphorus by broiler chickens. Three experiments were performed using 120 birds each, divided into five treatments with eight replicates per group (n = 3), identified as: experiment 1 (xylanase: control, 1000 IU, 1500 IU, 2000 IU, 2500 IU), experiment 2 (phytase: control, 500 FTU, 1000 FTU, 1500 FTU, 2000 FTU), experiment 3 (xylanase + phytase: control, 3000 IU + 500 FTU, 3000 IU + 1000 FTU, 3000 IU + 1500 FTU, 3000 IU + 2000 FTU). Samples for digestibility tests were collected at 14 to 21 days of age. Therefore, the inclusion of liquid phytase and liquid phytase + xylanase after pelletization in broiler diets has become a relevant way to reduce the inclusion of inorganic P, which can reduce the cost of feed and P excretion in the environment. Furthermore, it is an interesting strategy to avoid enzyme denaturation in the pelleting process. associated chickens 12 each n 3, , 3) as control 100 150 200 250 IU) (phytase 50 FTU FTU) 300 FTU. . age Therefore environment Furthermore process 10 15 20 25 5 30

Abstract Background Despite no evidence showing benefits of hydroxychloroquine and chloroquine with or without azithromycin for COVID-19 treatment, these medications have been largely prescribed in Brazil. Objectives To assess outcomes, including in-hospital mortality, electrocardiographic abnormalities, hospital length-of-stay, admission to the intensive care unit, and need for dialysis and mechanical ventilation, in hospitalized COVID-19 patients who received chloroquine or hydroxychloroquine, and to compare outcomes between those patients and their matched controls. Methods A retrospective multicenter cohort study that included consecutive laboratory-confirmed COVID-19 patients from 37 Brazilian hospitals from March to September 2020. Propensity score was used to select matching controls by age, sex, cardiovascular comorbidities, and in-hospital use of corticosteroid. A p-value <0.05 was considered statistically significant. Results From 7,850 COVID-19 patients, 673 (8.6%) received hydroxychloroquine and 67 (0.9%) chloroquine. The median age in the study group was 60 years (46 - 71) and 59.1% were women. During hospitalization, 3.2% of patients presented side effects and 2.2% required therapy discontinuation. Electrocardiographic abnormalities were more prevalent in the chloroquine/hydroxychloroquine group (13.2% vs. 8.2%, p=0.01), and the long corrected QT interval was the main difference (3.6% vs. 0.4%, p<0.001). The median hospital length of stay was longer in the HCQ/CQ + AZT group than in controls (9.0 [5.0, 18.0] vs. 8.0 [4.0, 14.0] days). There was no statistical differences between groups in intensive care unit admission (35.1% vs. 32.0%; p=0.282), invasive mechanical ventilation support (27.0% vs. 22.3%; p=0.074) or mortality (18.9% vs. 18.0%; p=0.682). Conclusion COVID-19 patients treated with chloroquine or hydroxychloroquine had a longer hospital length of stay, when compared to matched controls. Intensive care unit admission, invasive mechanical ventilation, dialysis and in-hospital mortality were similar. COVID19 COVID 19 COVID-1 treatment Brazil inhospital lengthofstay, lengthofstay length-of-stay laboratoryconfirmed laboratory confirmed 3 2020 sex comorbidities corticosteroid pvalue p value 005 0 05 <0.0 significant 7850 7 850 7,85 8.6% 86 8 6 (8.6% 0.9% 09 9 (0.9% 46 (4 71 591 59 1 59.1 women hospitalization 32 2 3.2 22 2.2 discontinuation chloroquinehydroxychloroquine 13.2% 132 13 (13.2 vs 82 8.2% p=0.01, p001 p=0.01 , 01 p=0.01) 3.6% 36 (3.6 04 4 0.4% p<0.001. p0001 p<0.001 . 001 p<0.001) HCQCQ HCQ CQ 9.0 90 (9. 5.0, 50 5 [5.0 18.0 180 18 80 8. 4.0, 40 [4.0 14.0 140 14 days. days days) 35.1% 351 35 (35.1 32.0% 320 p=0.282, p0282 p=0.282 282 p=0.282) 27.0% 270 27 (27.0 22.3% 223 p=0.074 p0074 074 18.9% 189 (18.9 18.0% p=0.682. p0682 p=0.682 682 p=0.682) similar COVID1 COVID- 202 00 <0. 785 85 7,8 8.6 (8.6 0.9 (0.9 ( 59. 3. 2. 13.2 (13. 8.2 p00 p=0.0 3.6 (3. 0.4 p000 p<0.00 9. (9 5.0 [5. 18. 4.0 [4. 14. 35.1 (35. 32.0 p028 p=0.28 28 27.0 (27. 22.3 p=0.07 p007 07 18.9 (18. p068 p=0.68 68 20 <0 78 7, (8. 0. (0. 13. (13 p0 p=0. (3 p<0.0 5. [5 4. [4 35. (35 32. p02 p=0.2 27. (27 22. (18 p06 p=0.6 < (8 (0 (1 p=0 p<0. [ (2 p= p<0 p<

Resumo Fundamento Apesar da ausência de evidência mostrando benefícios da hidroxicloroquina e da cloroquina combinadas ou não à azitromicina no tratamento da covid-19, esses medicamentos têm sido amplamente prescritos no Brasil. Objetivos Avaliar desfechos, incluindo moralidade hospitalar, alterações eletrocardiográficas, tempo de internação, admissão na unidade de terapia intensiva, e necessidade de diálise e de ventilação mecânica em pacientes hospitalizados com covid-19 que receberam cloroquina ou hidroxicloroquina, e comparar os desfechos entre aqueles pacientes e seus controles pareados. Métodos Estudo multicêntrico retrospectivo do tipo coorte que incluiu pacientes com diagnóstico laboratorial de covid-19 de 37 hospitais no Brasil de março a setembro de 2020. Escore de propensão foi usado para selecionar controles pareados quanto a idade, sexo, comorbidades cardiovasculares, e uso de corticosteroides durante a internação. Um valor de p<0,05 foi considerado estatisticamente significativo. Resultados Dos 7850 pacientes com covid-19, 673 (8,6%) receberam hidroxicloroquina e 67 (0,9%) cloroquina. A idade mediana no grupo de estudo foi 60 (46-71) anos e 59,1% eram mulheres. Durante a internação, 3,2% dos pacientes apresentaram efeitos adversos e 2,2% necessitaram de interromper o tratamento. Alterações eletrocardiográficas foram mais prevalentes no grupo hidroxicloroquina/cloroquina (13,2% vs. 8,2%, p=0,01), e o prolongamento do intervalo QT corrigido foi a principal diferença (3,6% vs. 0,4%, p<0,001). O tempo mediano de internação hospitalar foi maior no grupo usando CQ/HCQ em relação aos controles (9,0 [5,0-18,0] vs. 8,0 [4,0-14,0] dias). Não houve diferenças estatisticamente significativas entre os grupos quanto a admissão na unidade de terapia intensiva (35,1% vs. 32,0%; p=0,282), ventilação mecânica invasiva (27,0% vs. 22,3%; p=0,074) ou mortalidade (18,9% vs. 18,0%; p=0,682). Conclusão Pacientes com covid-19 tratados com cloroquina ou hidroxicloroquina apresentaram maior tempo de internação hospitalar, em comparação aos controles. Não houve diferença em relação a admissão em unidade de terapia intensiva, necessidade de ventilação mecânica e mortalidade hospitalar. covid19, covid19 covid 19, 19 covid-1 3 2020 sexo cardiovasculares p005 p 0 05 p<0,0 significativo 785 8,6% 86 8 6 (8,6% 0,9% 09 9 (0,9% 4671 46 71 (46-71 591 59 1 59,1 mulheres 32 2 3,2 22 2,2 hidroxicloroquinacloroquina 13,2% 132 13 (13,2 vs 82 8,2% p=0,01, p001 p=0,01 , 01 p=0,01) 3,6% 36 (3,6 04 4 0,4% p<0,001. p0001 p<0,001 . 001 p<0,001) CQHCQ CQ HCQ 9,0 90 (9, 5,018,0 50180 5,0 18,0 5 18 [5,0-18,0 80 8, 4,014,0 40140 4,0 14,0 14 [4,0-14,0 dias. dias dias) 35,1% 351 35 (35,1 32,0% 320 p=0,282, p0282 p=0,282 282 p=0,282) 27,0% 270 27 (27,0 22,3% 223 p=0,074 p0074 074 18,9% 189 (18,9 18,0% 180 p=0,682. p0682 p=0,682 682 p=0,682) covid1 covid- 202 p00 p<0, 78 8,6 (8,6 0,9 (0,9 467 7 (46-7 59, 3, 2, 13,2 (13, 8,2 p=0,0 3,6 (3, 0,4 p000 p<0,00 00 9, (9 018 5,018, 5018 50 5, 18, [5,0-18, 014 4,014, 4014 40 4, 140 14, [4,0-14, 35,1 (35, 32,0 p028 p=0,28 28 27,0 (27, 22,3 p=0,07 p007 07 18,9 (18, p068 p=0,68 68 20 p0 p<0 (8, 0, (0, (46- 13, (13 p=0, (3 ( 5,018 501 [5,0-18 4,014 401 [4,0-14 35, (35 32, p02 p=0,2 27, (27 22, (18 p06 p=0,6 p< (8 (0 (46 (1 p=0 5,01 [5,0-1 4,01 [4,0-1 (2 (4 p= [5,0- [4,0- [5,0 [4,0 [5, [4, [5 [4 [

RESUMEN Objetivo: Referir la experiencia de enfermeros de una Unidad Sanitaria Móvil en la atención a la población indígena venezolana de la etnia Warao, en Maceió/AL, a partir de la Teoría Transcultural de Madeleine Leininger. Metodología: Se trata de un estudio descriptivo, del tipo informe de experiencia, basado en la atención a la población indígena Warao a la luz de la Teoría Transcultural de Madeleine Leininger, realizado durante el año 2022. Resultados: Se utilizaron tecnologías leves para crear vínculos y comprender el universo cultural del pueblo Warao. Los conceptos de preservación, acomodación y reestructuración cultural de los cuidados de la teoría transcultural de Leininger ayudaron a dilucidar la práctica. Se ofreció atención integral según los programas recomendados por el Ministerio de Salud, con atención transcultural y se respetó el rechazo a la atención. La barrera lingüística y las creencias sanitarias representaron desafíos en el contexto de la atención singular. Conclusión: La experiencia de los enfermeros de la Unidad Sanitaria Móvil en la atención a la población indígena favoreció mucho la interacción social y amplió las posibilidades de lograr una atención sanitaria integral. La aplicación de la Teoría Transcultural demostró ser un dispositivo eficaz y adecuado para el cuidado de la salud. Objetivo MaceióAL Maceió AL Maceió/AL Metodología descriptivo 2022 Resultados preservación práctica Salud singular Conclusión salud 202 20 2

ABSTRACT Objective: To report on the experience of nurses from the Street Clinic in caring for the Indigenous Venezuelan population of the Warao ethnic group in Maceió/AL based on Madeleine Leininger’s Transcultural Theory. Metodology: A descriptive study, of the experience report type, based on the care of the Warao Indigenous population in the light of Madeleine Leininger’s Transcultural Theory, carried out during the year 2022. Results: Light technologies were used to form bonds and understand the cultural universe of the Warao people. The concepts of preservation, accommodation and cultural restructuring of care from Leininger’s transcultural theory helped to elucidate the practice. Comprehensive care was offered in accordance with the programs recommended by the Ministry of Health, with transcultural care, including respect for refusal of care. The language barrier and health beliefs represented challenges in the context of singular care. Final considerations: The experience of nurses from the Street Clinic in caring for the Indigenous population favored significant social interaction and expanded the possibilities for achieving comprehensive health care. The application of Transcultural Theory proved to be an effective and congruent device for health care. Objective MaceióAL Maceió AL Leiningers Leininger s Metodology study type 2022 Results people preservation practice Health considerations 202 20 2

RESUMO Objetivo: Relatar a experiência de enfermeiros do Consultório na Rua no cuidado à população indígena venezuelana da etnia Warao em Maceió/AL a partir da Teoria Transcultural de Madeleine Leininger. Metodologia: Estudo descritivo, do tipo relato de experiência, a partir do cuidado da população indígena Warao à luz da Teoria Transcultural de Madeleine Leininger, realizado durante o ano de 2022. Resultados: Utilizaram-se tecnologias leves para formação de vínculo e compreensão do universo cultural do povo Warao. Os conceitos de preservação, acomodação e reestruturação cultural do cuidado da teoria Transcultural de Leininger contribuíram para elucidar a prática vivenciada. Ofertou-se uma atenção integral conforme os programas preconizados pelo Ministério da Saúde, com cuidado transcultural, inclusive com respeito à recusa de assistência. A barreira linguística e as crenças no que tange à saúde representaram desafios no contexto do cuidado singular. Conclusão: A experiência de enfermeiros do Consultório na Rua no cuidado a população indígena favoreceu uma significativa interação social e ampliou as possibilidades para o alcance da integralidade em saúde. A aplicação da Teoria Transcultural se mostrou como um dispositivo eficaz e congruente para o cuidado em saúde. Objetivo MaceióAL Maceió AL Metodologia descritivo 2022 Resultados Utilizaramse Utilizaram preservação vivenciada Ofertouse Ofertou Saúde transcultural assistência singular Conclusão 202 20 2

Abstract The purpose of this study was to isolate Toxoplasma gondii from tissues of free-range chickens in the southwestern region of Goiás, to detect and molecularly characterize the genetic material of the parasite, and to determine the seroprevalence of the protozoan parasite in these animals. A seroprevalence of T. gondii antibodies of 76% (19/25) was found among the chickens, while genetic material from their tissues was detected in 56% (14/25). A total of 14 isolates was obtained in the bioassay, ten of which were considered acute, eight were considered isolates of high virulence lethal to mice, and four of low virulence, considered non-lethal but with the ability to chronify the infection. Seven of the ten isolates showed significant morphometric differences from the RH strain, in terms of nucleus-complex-apical distance, length and width. Genotyping of the acute isolates was performed by RFLP-PCR, using 11 genetic markers: SAG1, SAG2 (3’SAG2 and 5’SAG2), alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, and APICO. The results were compared and classified according to the genotypes listed on the ToxoDB Platform, where different profiles were observed indicating the presence of two known genotypes (#7 and #63) and five new genotypes (NEW 3, NEW4, NEW5, NEW6, NEW 7). The results showed high seroprevalence, isolation rate, molecular detection and genotypic variations of T. gondii in free-range chickens in the southwestern region of Goiás. freerange free range Goiás animals T 76 19/25 1925 19 25 (19/25 56 14/25. 1425 14/25 . (14/25) 1 bioassay mice nonlethal non infection strain nucleuscomplexapical nucleus complex apical distance width RFLPPCR, RFLPPCR RFLP PCR, PCR RFLP-PCR markers SAG1 SAG 3SAG2 3 (3’SAG 5SAG2, 5SAG2 5 , 5’SAG2) altSAG2 altSAG alt alt.SAG2 SAG3 BTUB GRA6 GRA c228, c228 c c22 8, 8 c22-8 c292, c292 c29 2, 2 c29-2 L358 L PK1 PK APICO Platform #7 7 (# #63 63 NEW4 NEW5 NEW6 7. 7) rate 19/2 192 (19/2 142 14/2 (14/25 3SAG 5SAG 5’SAG2 alt.SAG c2 c22- c29- L35 # ( #6 6 19/ (19/ 14/ (14/2 5’SAG L3 (19 (14/ (1 (14

Resumo O objetivo deste estudo foi isolar Toxoplasma gondii de tecidos de galinhas caipiras da região sudoeste de Goiás, detectar e caracterizar molecularmente o material genético do parasito e determinar a soroprevalência do protozoário nestes animais. A soropositividade para anticorpos anti- T. gondii, nas galinhas caipiras, foi de 76% (19/25), enquanto a detecção do material genético dos tecidos foi de 56% (14/25). Por meio do bioensaio foi obtido um total de 14 isolados, sendo 10 agudos, dos quais oito foram considerados isolados de elevada virulência, sendo letais para camundongos; e quatro de baixa virulência, com capacidade de cronificar a infecção, considerados não letais. Em sete dos dez isolados foram identificadas diferenças morfométricas significativas em relação à cepa RH, quanto à distância núcleo-complexo apical, comprimento e largura. A genotipagem dos isolados agudos por RFLP-PCR foi realizada, utilizando-se 11 marcadores genéticos SAG1, SAG2 (3´SAG2 e 5´SAG2), alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, APICO. Os resultados foram comparados e classificados de acordo com os genótipos presentes na Plataforma ToxoDB, nos quais diferentes perfis foram observados indicando a presença de dois genótipos conhecidos (#7 e #63) e cinco genótipos novos (NEW 3, NEW4, NEW5, NEW6, NEW 7). Os resultados demonstraram elevada soroprevalência, taxa de isolamento, detecção molecular e variações genotípicas de T. gondii em galinhas caipiras da região sudoeste de Goiás. Goiás animais anti T 76 19/25, 1925 19/25 , 19 25 (19/25) 56 14/25. 1425 14/25 . (14/25) 1 virulência camundongos infecção RH núcleocomplexo núcleo complexo apical largura RFLPPCR RFLP PCR realizada utilizandose utilizando se SAG1 SAG 3´SAG2 3SAG2 3 (3´SAG 5´SAG2, 5SAG2 5´SAG2 5 5´SAG2) altSAG2 altSAG alt alt.SAG2 SAG3 BTUB GRA6 GRA c228, c228 c c22 8, 8 c22-8 c292, c292 c29 2, 2 c29-2 L358 L PK1 PK APICO ToxoDB #7 7 (# #63 63 NEW4 NEW5 NEW6 7. 7) isolamento 192 19/2 (19/25 142 14/2 (14/25 3´SAG 3SAG 5SAG 5´SAG alt.SAG c2 c22- c29- L35 # ( #6 6 19/ (19/2 14/ (14/2 L3 (19/ (14/ (19 (14 (1

RESUMEN Objetivo: Analizar la relación entre el coaching de liderazgo y la resiliencia de enfermeros en el ambiente hospitalario. Método: Estudio transversal, realizado con enfermeros, auxiliares y técnicos de enfermería. Los enfermeros respondieron el Cuestionario de Autopercepción de Enfermeros en el Ejercicio del Liderazgo (QUAPEEL) y la Escala de Connor-Davidson para Brasil-25 (CD-RISC-BRASIL). Los técnicos/auxiliares de enfermería respondieron el Cuestionario de Percepción del Técnico y Auxiliar de Enfermería en el Ejercicio del Liderazgo (QUEPTAEEL). Se utilizó la prueba t de Student y la Correlación de Pearson (p ≤ 0.05). Resultados: Hubo diferencia estadísticamente significativa entre la autopercepción de los enfermeros y la heteropercepción de los técnicos/auxiliares de enfermería en el ejercicio del liderazgo de coaching para la puntuación total (p = 0,002) y en los dominios “Dar y recibir feedback” (p < 0,001), “Dar poder y ejercer influencia” (p < 0,001) y “Apoyar al equipo para lograr resultados” (p = 0,020). Hubo correlación estadísticamente significativa entre todos los dominios del Cuestionario de Autopercepción del Enfermero en el Ejercicio del Liderazgo, Coaching y Resiliencia. Conclusión: La resiliencia se relacionó positivamente con la autopercepción de los enfermeros sobre el liderazgo en el entrenamiento. Objetivo hospitalario Método transversal QUAPEEL (QUAPEEL ConnorDavidson Connor Davidson Brasil25 Brasil 25 Brasil-2 CDRISCBRASIL. CDRISCBRASIL CD RISC BRASIL . (CD-RISC-BRASIL) técnicosauxiliares QUEPTAEEL. QUEPTAEEL (QUEPTAEEL) p 0.05. 005 0.05 0 05 0.05) Resultados 0,002 0002 002 Dar feedback 0,001, 0001 0,001 , 001 influencia Apoyar resultados 0,020. 0020 0,020 020 0,020) Resiliencia Conclusión entrenamiento Brasil2 2 Brasil- (CD-RISC-BRASIL (QUEPTAEEL 00 0.0 0,00 000 0,02 02 0. 0,0 0,

ABSTRACT Objective: To analyze the relationship between leadership coaching and nurses’ resilience in hospital environments. Method: This is a cross-sectional study, carried out with nurses, nursing assistants and technicians. Nurses answered the Nurse Self-Perception Questionnaire in Leadership Exercise Questionnaire (QUAPEEL) and the Connor-Davidson Scale for Brazil-25 (CD-RISC-25BRASIL). Nursing technicians/assistants answered the Nursing Technician and Assistant Perception in Leadership Exercise Questionnaire (QUEPTAEEL). Student’s t test and Pearson’s correlation were used (p ≤ 0.05). Results: There was a statistically significant difference between nurses’ self-perception and nursing technicians/assistants’ hetero-perception in coaching leadership exercise for the total score (p = 0.002) and in the “Give and receive feedback” (p < 0.001), “Delegate power and exert influence” (p < 0.001) and “Support the team so that the organizational results are reached” (p = 0.020) domains. There was a statistically significant correlation between all the Nurse Self-Perception Questionnaire in Leadership Exercise Questionnaire Coaching and Resilience domains. Conclusion: Resilience was positively related to nurses’ self-perception of coaching leadership. Objective nurses environments Method crosssectional cross sectional study technicians SelfPerception Self QUAPEEL (QUAPEEL ConnorDavidson Connor Davidson Brazil25 Brazil 25 Brazil-2 CDRISC25BRASIL. CDRISC25BRASIL CDRISCBRASIL CD RISC 25BRASIL . BRASIL (CD-RISC-25BRASIL) techniciansassistants QUEPTAEEL. QUEPTAEEL (QUEPTAEEL) Students Student s Pearsons Pearson p 0.05. 005 0.05 0 05 0.05) Results selfperception self perception heteroperception hetero 0.002 0002 002 Give feedback 0.001, 0001 0.001 , 001 Delegate influence Support reached 0.020 0020 020 domains Conclusion Brazil2 2 Brazil- CDRISC (CD-RISC-25BRASIL (QUEPTAEEL 00 0.0 0.00 000 0.02 02 0.

RESUMO Objetivo: Analisar a relação entre liderança coaching e resiliência dos enfermeiros no ambiente hospitalar. Método: Estudo transversal, realizado com enfermeiros, auxiliares e técnicos de enfermagem. Os enfermeiros responderam ao Questionário de Autopercepção do Enfermeiro no Exercício da Liderança (QUAPEEL) e à Escala de Connor-Davidson para o Brasil-25 (CD-RISC-25BRASIL). Os técnicos/auxiliares de enfermagem responderam ao Questionário de Percepção do Técnico e Auxiliar de Enfermagem no Exercício da Liderança (QUEPTAEEL). Os Testes t de Student e Correlação de Pearson foram utilizados (p ≤ 0,05). Resultados: Verificou-se diferença estatisticamente significante entre autopercepção dos enfermeiros e heteropercepção dos técnicos/auxiliares de enfermagem no exercício da liderança coaching para pontuação total (p = 0,002) e nos seus domínios “Dar e receber feedback” (p < 0,001), “Dar poder e exercer influência” (p < 0,001) e “Apoiar a equipe para o alcance dos resultados” (p = 0,020). Houve correlação estatisticamente significante entre todos os domínios do Questionário de Autopercepção do Enfermeiro no Exercício da Liderança Coaching e Resiliência. Conclusão: A resiliência se relacionou positivamente com a autopercepção de liderança coaching dos enfermeiros. Objetivo hospitalar Método transversal QUAPEEL (QUAPEEL ConnorDavidson Connor Davidson Brasil25 Brasil 25 Brasil-2 CDRISC25BRASIL. CDRISC25BRASIL CDRISCBRASIL CD RISC 25BRASIL . BRASIL (CD-RISC-25BRASIL) técnicosauxiliares QUEPTAEEL. QUEPTAEEL (QUEPTAEEL) p 0,05. 005 0,05 0 05 0,05) Resultados Verificouse Verificou 0,002 0002 002 Dar feedback 0,001, 0001 0,001 , 001 influência Apoiar resultados 0,020. 0020 0,020 020 0,020) Resiliência Conclusão Brasil2 2 Brasil- CDRISC (CD-RISC-25BRASIL (QUEPTAEEL 00 0,0 0,00 000 0,02 02 0,