Abstract Objective To evaluate whether antimicrobial photodynamic therapy (aPDT) repairs bisphosphonate-related osteonecrosis of the jaw (BRONJ) modulated by the reduction of NF-kB protein in a murine model. Methodology Male Wistar rats (N=30) were divided into the following groups (n=6/group): negative control (NC); experimental osteonecrosis (ONE); ONE + photosensitizer (PS); ONE + photobiomodulation (PBM); and ONE + aPDT. Over 8 weeks, ONE was induced by zoledronic acid 250 µg/kg injections, except in the NC group, which received sterile 0.9% saline, followed by extraction of the lower left first molar. Red light laser irradiation (wavelength ~660 nm, power 50 mW, energy of 2 J, energy dose of 66.67 J/cm2 for 40 s) was performed once a week for 4 weeks. Methylene blue 0.3% was used as PS. The animals were euthanized and examined macroscopically for the presence of exposed bone and epithelial repair and microscopically by histochemical (hematoxylin-eosin and Masson’s trichrome staining) and immunohistochemical (anti-NF-kB) methods. Macroscopic and histomorphometric data were analyzed by one-way ANOVA and Tukey’s post-test (p<0.05). Results Mucosal repair, viable osteocytes, and NF-kB immunostaining were observed in the NC, ONE+PS, ONE+PBM, and ONE+aPDT groups. The ONE group showed no mucosal repair, showing empty lacunae and multifocal immunostaining for NF-kB. The ONE+PBM and ONE+aPDT groups had greater deposition of extracellular matrix and less necrotic bone tissue (p<0.05). Conclusion PBM and aPDT treatments for BRONJ were effective for bone and epithelial repair, in addition to reducing inflammation mediated by the decrease of NF-kB protein in the irradiated regions. (aPDT bisphosphonaterelated bisphosphonate related (BRONJ NFkB NF kB model N=30 N30 N 30 (N=30 n=6/group n6group ngroup n 6 (n=6/group) (NC) (ONE) PS (PS) (PBM) weeks 25 µgkg µg kg injections 09 0 9 0.9 saline molar wavelength 660 ~66 nm 5 mW J 6667 66 67 66.6 Jcm2 Jcm cm2 cm J/cm s 03 3 0.3 hematoxylineosin hematoxylin eosin Massons Masson staining antiNFkB anti (anti-NF-kB methods oneway one way Tukeys Tukey posttest post test p<0.05. p005 p p<0.05 . 05 (p<0.05) osteocytes ONEPS ONE+PS ONEPBM ONEaPDT NFkB. kB. regions N=3 N3 (N=3 (n=6/group (NC (ONE (PS (PBM 0. ~6 666 66. p00 p<0.0 (p<0.05 N= (N= ~ p0 p<0. (p<0.0 (N p<0 (p<0. p< (p<0 (p< (p

Abstract Objectives Our study aimed to verify the evidence of auditory training employed in the audiological treatment of tinnitus in adults and older adults. Methods Scoping review based on a search for articles in journals available in MEDLINE (PubMed), Embase (Elsevier), LILACS (BVS), and Cochrane Library. Titles and abstracts of the retrieved articles were assessed by peers, following the eligibility criteria; they were afterward read in full text, and the references were hand searched in the results found. Studies’ level of evidence was classified into very high (Level A+), high (Level A), moderate (Level B), limited (Level C), low (Level D), or very low (Level D−) based on the Critically Appraised Topics. Results 2160 records were identified in the searching stage and 15 studies were eligible for data extraction. Study design, sample characterization, auditory training tasks, sound stimuli, outcome measures, and results were extracted. Frequency discrimination training was the most frequent strategy, followed by auditory attentional skills training and multisensory training. Almost all studies with daily auditory training sessions reported significant benefits demonstrated in at least one outcome measure. Studies that used auditory discrimination training and attentional auditory skill stimulation to treat tinnitus obtained quality evidence levels ranging from limited to high (C‒A) and studies that applied multisensory training or attentional training combined with counseling and passive listening in tinnitus patients reached a high-quality evidence level (A). Conclusion Recent studies had higher levels of evidence and considered attentional factors and multisensory pathways in auditory training strategies. PubMed, PubMed , (PubMed) Elsevier, Elsevier (Elsevier) BVS, BVS (BVS) Library peers criteria text found Level A+, A A+ A+) A, A) B, B B) C, C C) D, D D) D− Topics 216 1 extraction design characterization tasks stimuli measures extracted strategy measure C‒A CA (C‒A highquality A. . (A) strategies (PubMed (Elsevier (BVS 21 (A 2

Abstract This article addresses commodity export capitalism in Latin America in the 21st century, having as its core the power relations between companies and public agents in the management of Brazilian rail infrastructure, addressing the case of the Malha Regional Sudeste (MRS), under the management of the concessionaire MRS Logística S/A. It is based on the Marxist literature on the capitalist production of space and infrastructure. It examines official publications from the competent government agencies and the company and brings a perspective rooted in an environment directly impacted by business activities. It exposes the circumstances under which MRS finds itself and discusses the company’s devices and practices to legitimize its power over the territories where it operates, using political, legal, economic and sociocultural technologies typical of neoliberal governmentality. st century infrastructure MRS, , (MRS) SA S A S/A activities companys s operates political legal governmentality (MRS

Resumo Este artigo aborda o capitalismo exportador de commodities na América Latina no século XXI, tendo como cerne as relações de poder entre empresas e agentes públicos na gestão da infraestrutura ferroviária brasileira, abordando o caso da Malha Regional Sudeste (MRS), sob gestão da concessionária MRS Logística S/A. Fundamenta-se na literatura marxista sobre a produção capitalista do espaço e as infraestruturas. Examina publicações oficiais dos órgãos governamentais competentes e da empresa, trazendo uma perspectiva enraizada em um ambiente diretamente impactado pela atuação empresarial. Expõe circunstâncias sob as quais está a MRS e discute artifícios e práticas da empresa para a legitimação do seu poder sobre os territórios onde atua, utilizando-se de tecnologias políticas, jurídicas, econômicas e socioculturais próprias da governamentalidade neoliberal. XXI brasileira MRS, , (MRS) SA S A S/A Fundamentase Fundamenta se infraestruturas empresarial atua utilizandose utilizando políticas jurídicas neoliberal (MRS

ABSTRACT Wild birds have great prominence in the transmission of diseases to humans, mainly due to their ease of access to human populations, raising concerns about the potential impact of that proximity on public health. The present study reports ARV and PBV occurrence in wild birds from an environmental protection area in the Amazon biome, in Pará state, Brazil. We obtained 155 fecal specimens from 47 species of wild birds for RNA extraction, ARV and PBV detection utilizing molecular methods, nucleotide sequencing, and phylogenetic analysis. ARV prevalence was 0.6% (1/155), being positive in an individual of Myrmotherula longipennis, and PBV prevalence was 1.29% (2/155), affecting two individuals of Guira guira. The PBV strains were assigned to genogroup I based on phylogenetic analysis, and they shared a strong phylogenetic link with strains isolated from different geographic locations. The ARV strain was more closely related to strains that had previously circulated in the same region. The presence of ARV and PBV in this habitat suggests that infection cycles of these agents occur naturally in the wild ecosystem, potentially triggering transmission events between bird species and humans. This is the first study on ARV detection in wild birds in Brazil and the first report on the occurrence of PBV in wild Guira guira. Additional studies are required to determine the epidemiology, origin, evolution, and emergence of new potentially pathogenic viruses in the Amazon. humans populations health biome state 15 4 extraction methods sequencing analysis 06 0 6 0.6 1/155, 1155 1/155 , 1 (1/155) longipennis 129 29 1.29 2/155, 2155 2/155 2 (2/155) guira locations region ecosystem epidemiology origin evolution 0. 115 1/15 (1/155 12 1.2 215 2/15 (2/155 11 1/1 (1/15 1. 21 2/1 (2/15 1/ (1/1 2/ (2/1 (1/ (2/ (1 (2 (

RESUMO As aves silvestres têm grande destaque na transmissão de doenças ao homem, principalmente pela facilidade de acesso à população humana, levantando preocupações sobre o potencial impacto dessa proximidade no contexto da saúde pública. O presente estudo relata a ocorrência de ARV e PBV em aves silvestres de uma área de proteção ambiental no bioma Amazônico. Obtivemos 155 espécimes fecais de 47 espécies de aves silvestres, que foram submetidos a extração de RNA, detecção de ARV e PBV por técnicas moleculares, sequenciamento nucleotídico e análise filogenética. A prevalência de infecção por ARV foi 0,6% (1/155), sendo positivo em um indivíduo de Myrmotherula longipennis, e a prevalência de PBV foi 1,29% (2/155), afetando dois insdivíduos de Guira guira. A análise filogenética agrupou as cepas de PBV no genogrupo I, mostrando intensa relação filogenética com cepas isoladas de outras regiões geográficas. A cepa de ARV esteve mais relacionada filogeneticamente a cepas previamente circulantes na mesma região. Este é o primeiro estudo sobre detecção de ARV em aves silvestres no Brasil e o primeiro relato sobre a ocorrência de PBV em Guira guira. A circulação de ARV e PBV nesse ambiente demonstra que os ciclos desses agentes estão ocorrendo de forma natural no ecossistema silvestre, o que pode desencadear possíveis eventos de transmissão entre as espécies aviárias e humanos. Estudos adicionais são necessários para determinar a epidemiologia, origem, evolução e surgimento de novos vírus potencialmente patogênicos na Amazônia. homem humana pública Amazônico 15 4 RNA moleculares 06 0 6 0,6 1/155, 1155 1/155 , 1 (1/155) longipennis 129 29 1,29 2/155, 2155 2/155 2 (2/155) guira I geográficas região silvestre humanos epidemiologia origem Amazônia 0, 115 1/15 (1/155 12 1,2 215 2/15 (2/155 11 1/1 (1/15 1, 21 2/1 (2/15 1/ (1/1 2/ (2/1 (1/ (2/ (1 (2 (

Stemodin (1) is a diterpene produced by Stemodia maritima L. (Scrophulariaceae) and shows antiviral and tumor cell proliferation inhibitory activities. Chemical modifications of 1 were performed to produce the known stemodinone (2), two new stemodinone oximes, Z (3) and E (4), and seven new oxime esters derivatives (5, 6, 7, 8, 9, 10, and 11). All derivatives were evaluated for their cytotoxic activity in HL60 (promyelocytic leukemia), SNB-19 (astrocytoma), HCT-116 (colon carcinoma), and PC3 (prostate) human cancer cell lines, and L929 (healthy murine cells). Oximes 3 and 4 showed lower cytotoxic values than 1 against all cancer cell lines tested. However, esters 9 and 10 exhibited cell growth inhibition percentages higher than 1 against PC3, SNB-19, and HCT-116 cancer cell lines, ranging from 62.96 to 94.27%. Many of these values exceed that presented by doxorubicin (66.05-86.87%). All compounds showed no cytotoxic effect on healthy cells at the tested concentration of 25 µg mL-1. (1 L Scrophulariaceae (Scrophulariaceae activities 2, 2 , (2) oximes (3 4, (4) 5, 5 (5 6 7 8 11. 11 . 11) HL HL6 promyelocytic leukemia, leukemia leukemia) SNB19 SNB 19 SNB-1 astrocytoma, astrocytoma (astrocytoma) HCT116 HCT 116 HCT-11 colon carcinoma, carcinoma carcinoma) PC prostate (prostate L92 cells. cells) However SNB19, 19, 6296 62 96 62.9 9427 94 27 94.27% 66.0586.87%. 66058687 66.05 86.87% 66 05 86 87 (66.05-86.87%) mL1. mL1 mL 1. mL-1 ( (2 (4 SNB1 SNB- (astrocytoma HCT11 HCT-1 L9 629 62. 942 94.27 0586 66.0586.87% 6605868 6605 66.0 8687 86.87 0 (66.05-86.87% mL- HCT1 HCT- 94.2 058 66.0586.87 660586 660 66. 868 86.8 (66.05-86.87 94. 66.0586.8 66058 86. (66.05-86.8 66.0586. (66.05-86. 66.0586 (66.05-86 66.058 (66.05-8 (66.05- (66.05 (66.0 (66. (66 (6

Resumo Objetivou-se analisar como os profissionais de uma rede de serviços intersetoriais desenvolvem ações de cuidado aos adolescentes com comportamentos suicidas e autolesivos. Trata-se de um estudo descritivo e exploratório de abordagem qualitativa, realizado através de anotações no diário de campo e entrevistas semiestruturadas com 22 profissionais vinculados a serviços da assistência social, educação e saúde de um município de grande porte do nordeste brasileiro. A coleta de dados ocorreu no período de agosto a setembro de 2021. Os discursos foram submetidos à análise de conteúdo na modalidade temática indutiva, com suporte do software Nvivo 11 Pro. Diante disso, duas categorias emergiram: estratégias de cuidado da rede intersetorial e fragilidades no cuidado. Os profissionais percebem os adolescentes como sujeitos que necessitam de suporte para o sofrimento psíquico apresentado. Deste modo desenvolvem, como principais estratégias de cuidado, o acolhimento e as atividades de prevenção, estas de modo pontual. Contudo, a rede de cuidados mostra-se insuficiente, devido à escassez de políticas infantojuvenis e serviços especializados, além de dificuldades na prática da intersetorialidade. Conclui-se que o cuidado ofertado aos adolescentes é fragilizado e necessita do fortalecimento de políticas públicas transversais, ampliação dos serviços primários/especializados e do trabalho intersetorial. Objetivouse Objetivou se autolesivos Tratase Trata qualitativa 2 social brasileiro 2021 indutiva 1 Pro disso emergiram apresentado prevenção pontual Contudo mostrase mostra insuficiente especializados intersetorialidade Concluise Conclui transversais primáriosespecializados primários 202 20

Abstract It aimed to analyze how professionals from an intersectoral service network develop care actions for adolescents with suicidal and self-injurious behaviors. This is a descriptive and exploratory study with a qualitative approach, carried out through notes in the field diary and semi-structured interviews with 22 professionals linked to social assistance, education and health services in a large municipality in northeastern Brazil. Data collection took place from August to September 2021. The speeches were subjected to content analysis in the inductive thematic modality, with support from the Nvivo 11 Pro software. Given this, two categories emerged: intersectoral network care strategies and weaknesses in care. Professionals perceive adolescents as subjects who need support for their psychological suffering. In this way, they develop, as the main care strategies, reception and prevention activities, on a punctual basis. However, the care network appears to be insufficient, due to the scarcity of child and youth policies and specialized services, in addition to difficulties in practicing intersectorality. It is concluded that the care offered to adolescents is fragile and requires the strengthening of transversal public policies, expansion of primary/specialized services and intersectoral work. selfinjurious self injurious behaviors approach semistructured semi structured 2 assistance Brazil 2021 modality 1 software emerged suffering way activities basis However insufficient intersectorality primaryspecialized primary work 202 20

Resumo Objetivo: O objetivo deste estudo foi explorar a relação entre liderança pró-social, capacidade de inovação e desempenho organizacional em empresas familiares. Originalidade/valor: O estudo apresenta um modelo, resultado das relações entre três diferentes teorias, no contexto das empresas familiares. Estudar a liderança pró-social e a capacidade de inovação permitiu uma visão sistêmica sobre novas perspectivas que possam interpretar melhor a realidade das empresas familiares. No que diz respeito às contribuições empíricas e sociais, foi possível sugerir linhas de ação para o desenvolvimento de líderes pró-sociais, fomentando a inovação e, consequentemente, contribuindo para o desempenho organizacional. Design/metodologia/abordagem: O estudo teve abordagem quantitativa com objetivo descritivo, utilizando o método de pesquisa survey e técnicas estatísticas para análise dos dados. A amostra foi composta por 502 profissionais que exercem cargos de liderança nas empresas membros da Associação de Distribuidores e Atacadistas Catarinenses. Resultados: As hipóteses confirmaram que há relações positivas entre liderança pró-social e capacidade de inovação; entre liderança pró-social e desempenho organizacional; entre capacidade de inovação e desempenho organizacional. Também foi possível afirmar que existe um efeito moderador parcial da capacidade de inovação sobre a relação entre liderança pró-social e desempenho. Objetivo prósocial, prósocial pró social, social familiares Originalidade/valor Originalidadevalor Originalidade valor modelo teorias sociais prósociais, prósociais pró-sociais consequentemente Design/metodologia/abordagem Designmetodologiaabordagem Design metodologia descritivo dados 50 Catarinenses Resultados 5

Abstract Purpose: This study explored the relationship between prosocial leadership, innovation capacity, and organizational performance in family businesses. Originality/value: The study presents a model resulting from the relationships between three theories in the context of family businesses. Studying prosocial leadership and innovation capacity enabled a systemic view of new perspectives that can better interpret the reality of family businesses. Regarding empirical and social contributions, we suggested lines of action for developing prosocial leaders and fostering innovation, thus contributing to organizational performance. Design/methodology/approach: The study had a quantitative approach with a descriptive nature, using the survey research method and statistical techniques for data analysis. The sample consisted of 502 professionals who hold leadership positions in member companies of the Association of Santa Catarina Distributors and Wholesalers. Findings: The hypotheses confirmed positive relationships between prosocial leadership and innovation capacity, prosocial leadership and organizational performance, and innovation capacity and organizational performance. We also state that innovation capacity partially moderates the relationship between prosocial leadership and performance. Purpose businesses Originality/value Originalityvalue Originality value contributions Design/methodology/approach Designmethodologyapproach Design methodology nature analysis 50 Wholesalers Findings 5

Abstract This article aims to investigate the implications of grief among family members of COVID-19 victims; verify the prevalence of prolonged grief symptoms; and identify family members’ expectations regarding end-of-life care for their loved ones affected by COVID-19. Descriptive, cross-sectional research, with a quantitative-qualitative approach. Data collection was performed using an online questionnaire, guided by the PG-13 instrument. Descriptive and inferential statistics were applied. The results were presented descriptively and with the aid of tables. The study sample included 142 family members, mostly female, who presented emotional, physical, social, and financial implications as a result of grief. A prevalence of prolonged grief symptoms was observed in 11.4% of the mourners with more than six months and 29.6% of those with less than six months. Three thematic categories were identified: transparency in communicating the health situation, access to moments of farewell, and promotion of comfort in care actions. The symptoms of Prolonged Grief Disorder have a significant association with the degree of kinship. In final care, family members’ expectations were classified as: permission for a dignified farewell, effective communication, and promotion of comfort and care.

Resumo O objetivo deste artigo é investigar implicações do luto em familiares de vítimas da COVID-19; verificar a prevalência de sintomas de luto prolongado; identificar expectativas dos familiares acerca do cuidado em fim de vida de seus entes acometidos por COVID-19. Pesquisa descritiva, transversal, com abordagem quanti-qualitativa. Coleta de dados mediante questionário on-line, norteado pelo instrumento PG-13. Aplicou-se estatística descritiva e inferencial. Os resultados foram apresentados de forma descritiva e com auxílio de tabelas. Amostra de 142 familiares, maioria do sexo feminino, que apresentaram implicações emocionais, físicas, sociais e financeiras em decorrência do luto. Houve prevalência de sintomas de luto prolongado em 11,4% dos enlutados com mais de seis meses e 29.6% dos que tinham menos de seis meses. Foram identificadas três categorias temáticas: transparência na comunicação da situação de saúde, acesso a momentos de despedida e promoção de conforto nas ações de cuidado. Os sintomas de Transtorno de Luto Prolongado possuem associação significativa com o grau de parentesco. Nos cuidados finais as expectativas dos familiares foram classificadas em: permissão para despedida digna, comunicação efetiva e promoção de conforto e cuidado.

Resumo O objetivo deste artigo é investigar implicações do luto em familiares de vítimas da COVID-19; verificar a prevalência de sintomas de luto prolongado; identificar expectativas dos familiares acerca do cuidado em fim de vida de seus entes acometidos por COVID-19. Pesquisa descritiva, transversal, com abordagem quanti-qualitativa. Coleta de dados mediante questionário on-line, norteado pelo instrumento PG-13. Aplicou-se estatística descritiva e inferencial. Os resultados foram apresentados de forma descritiva e com auxílio de tabelas. Amostra de 142 familiares, maioria do sexo feminino, que apresentaram implicações emocionais, físicas, sociais e financeiras em decorrência do luto. Houve prevalência de sintomas de luto prolongado em 11,4% dos enlutados com mais de seis meses e 29.6% dos que tinham menos de seis meses. Foram identificadas três categorias temáticas: transparência na comunicação da situação de saúde, acesso a momentos de despedida e promoção de conforto nas ações de cuidado. Os sintomas de Transtorno de Luto Prolongado possuem associação significativa com o grau de parentesco. Nos cuidados finais as expectativas dos familiares foram classificadas em: permissão para despedida digna, comunicação efetiva e promoção de conforto e cuidado. COVID19 COVID 19 COVID-19 COVID19. 19. transversal quantiqualitativa. quantiqualitativa quanti qualitativa. qualitativa quanti-qualitativa online, online on line, line on-line PG13. PG13 PG 13. 13 PG-13 Aplicouse Aplicou se inferencial tabelas 14 feminino emocionais físicas 114 11 4 11,4 296 29 6 29.6 temáticas saúde parentesco digna COVID1 1 COVID-1 PG1 PG-1 11, 2 29. COVID- PG-

Abstract This article aims to investigate the implications of grief among family members of COVID-19 victims; verify the prevalence of prolonged grief symptoms; and identify family members’ expectations regarding end-of-life care for their loved ones affected by COVID-19. Descriptive, cross-sectional research, with a quantitative-qualitative approach. Data collection was performed using an online questionnaire, guided by the PG-13 instrument. Descriptive and inferential statistics were applied. The results were presented descriptively and with the aid of tables. The study sample included 142 family members, mostly female, who presented emotional, physical, social, and financial implications as a result of grief. A prevalence of prolonged grief symptoms was observed in 11.4% of the mourners with more than six months and 29.6% of those with less than six months. Three thematic categories were identified: transparency in communicating the health situation, access to moments of farewell, and promotion of comfort in care actions. The symptoms of Prolonged Grief Disorder have a significant association with the degree of kinship. In final care, family members’ expectations were classified as: permission for a dignified farewell, effective communication, and promotion of comfort and care. COVID19 COVID 19 COVID-1 victims endoflife end life COVID19. 19. crosssectional cross sectional research quantitativequalitative quantitative qualitative approach questionnaire PG13 PG 13 PG-1 instrument applied tables 14 female emotional physical social 114 11 4 11.4 296 29 6 29.6 identified situation farewell actions kinship communication COVID1 1 COVID- PG1 PG- 11. 2 29.

ABSTRACT The study investigated the social skills (SS) present in interactions among characters in children’s books. The sample consisted of 77 works. In this way, 42 books presented 168 situations of interactions among characters that were categorized according to the system of classes and subclasses of HS in childhood proposed by Z. Del Prette and Del Prette. The Assertiveness class (56) was identified most frequently and making and refusing requests, a subclass of this category, was the one that had the most interactions (20). The Civility class (16) had the lowest frequency. It suggested that children’s literature can be used as a psychoeducational resource for acquiring SS from childhood and serve as an indispensable tool in the students’ literacy process in the initial grades. (SS childrens children s 7 works way 4 16 Z 56 (56 requests category 20. 20 . (20) (16 frequency students grades 1 5 (5 2 (20 (1 ( (2

RESUMO O estudo investigou as habilidades sociais (HS) presentes nas interações entre personagens de livros infantis. A amostra foi composta por 77 obras. Desse total, 42 livros apresentaram 168 situações de interações entre personagens que foram categorizadas segundo o sistema de classes e subclasses das HS na infância propostas por Z. Del Prette e Del Prette. A classe Assertividade (56) foi identificada em maior frequência e fazer e recusar pedidos, subclasse desta categoria, foi a que obteve mais interações (20). A classe Civilidade (16) apresentou a menor frequência. Sugere-se que a literatura infantil possa ser usada como recurso psicoeducativo para aquisição das HS desde a infância e servir como uma ferramenta indispensável no processo do letramento e alfabetização dos alunos nas séries iniciais. (HS infantis 7 obras total 4 16 Z 56 (56 pedidos categoria 20. 20 . (20) (16 Sugerese Sugere se iniciais 1 5 (5 2 (20 (1 ( (2

RESUMEN En el estudio se investigó las habilidades sociales (HS) presentes en las interacciones entre personajes de libros infantiles. La muestra se compuso por 77 obras. De ese total, 42 libros presentaron 168 situaciones de interacciones entre personajes que se categorizaron según el sistema de clases y subclases de las HS en la infancia propuestas por Z. Del Prette y Del Prette (2013). La clase Asertividad (56) se identificó en más frecuencia y hacer y rechazar pedidos, subclase de esta categoría, fue la que obtuvo más interacciones (20). La clase Civilidad (16) presentó la menos frecuencia. Se sugiere que la literatura infantil pueda ser utilizada como recurso psicoeducativo para adquisición de las HS desde la infancia y servir como una herramienta indispensable en el proceso de la alfabetización de los alumnos en los cursos iniciales. (HS infantiles 7 obras total 4 16 Z 2013. 2013 . (2013) 56 (56 pedidos categoría 20. 20 (20) (16 iniciales 1 201 (2013 5 (5 2 (20 (1 (201 ( (2

ABSTRACT The cultivation of beans (Phaseolus vulgaris L.) is of great importance to the national economy since they are grown in almost all regions of Brazil and the use of biostimulants based on phytohormones and plant vitamins can improve the yield of the crop. This work aimed to evaluate the effects of the application of the vitamin nicotinamide and phytohormones as biostimulants on bean plants. The experimental design was carried out in randomized blocks in a 2 x 5 factorial scheme with 4 replicates. The treatments consisted of the application of five doses of nicotinamide (0, 200, 400, 600 and 800 mg L-1) in the presence or absence of phytohormones containing auxin, gibberellin and cytokinin. The growth characteristics, production components and productivity of the bean grains were evaluated. The use of phytohormones and nicotinamide alone or together favored the growth, production components and grain productivity of the bean plant. The range of 366 to 469 mL L-1 nicotinamide achieved the highest values for the growth variables, production components and grain productivity of the bean plant, with 414 mL L-1 being the most suitable to achieve higher grain productivity. Phaseolus L. L crop plants replicates 0, 0 (0 200 400 60 80 L1 1 auxin cytokinin characteristics evaluated 36 46 L- variables 41 ( 20 40 6 8 3

Abstract Violence against women is defined as any act resulting from gender relations that cause death or physical, sexual, psychological, property and moral harm. Comprehensive care requires professionals understanding the support network to guide and refer women victims of violence to services and to value complaints/anxieties. The objective of this study was to identify the scientific production of comprehensive care for women victims of violence. This is an integrative literature review. Data collection was performed via a paired and independent search by two researchers in the Scopus, PubMed, CINAHL, Web of Science, LILACS, BDENF and SciELO databases between January and February 2023. After applying the eligibility criteria and descriptors in health sciences and medical subject headings, ten articles were retrieved. IRAMUTEQ software was used for data analyses. There are great challenges in implementing comprehensive care, and violence against women, as a serious social problem, demands health, education, social assistance and public security policies. The comprehensive actions taken in the care of women victims of violence demonstrate a strong link with the practices of reception and humanization, in addition to an interdisciplinary and intersectoral scope.

Resumo A violência direcionada à mulher é definida como todo ato resultante das relações de gênero que cause morte, dano físico, sexual, psicológico, patrimonial e moral. O cuidado integral possibilita que o profissional conheça a rede de apoio, a fim de orientá-las e encaminhá-las aos serviços, e valorize queixas/anseios. Objetivou-se identificar a produção científica acerca do cuidado integral às mulheres vítimas de violência. Trata-se de uma revisão integrativa da literatura. A coleta de dados ocorreu com busca pareada e independente de duas pesquisadoras, nos bancos Scopus, PubMed, CINAHL, Web of Science, LILACS, BDENF e SciELO, no período de janeiro e fevereiro de 2023. Foram utilizados critérios de elegibilidade, Descritores em Ciências da Saúde e Medical Subject Headings, totalizando dez artigos. Na análise dos dados, utilizou-se o software Iramuteq. Verificou-se grandes desafios para o cuidado integral, e que a violência contra a mulher, por ser uma problemática social grave, demanda políticas de saúde, educação, assistência social e segurança pública. Conclui-se que as ações integrais no cuidado à mulher vítima de violência demonstram forte vínculo com as práticas de acolhimento, humanização, além de perpassarem o âmbito interdisciplinar e intersetorial.

Abstract Violence against women is defined as any act resulting from gender relations that cause death or physical, sexual, psychological, property and moral harm. Comprehensive care requires professionals understanding the support network to guide and refer women victims of violence to services and to value complaints/anxieties. The objective of this study was to identify the scientific production of comprehensive care for women victims of violence. This is an integrative literature review. Data collection was performed via a paired and independent search by two researchers in the Scopus, PubMed, CINAHL, Web of Science, LILACS, BDENF and SciELO databases between January and February 2023. After applying the eligibility criteria and descriptors in health sciences and medical subject headings, ten articles were retrieved. IRAMUTEQ software was used for data analyses. There are great challenges in implementing comprehensive care, and violence against women, as a serious social problem, demands health, education, social assistance and public security policies. The comprehensive actions taken in the care of women victims of violence demonstrate a strong link with the practices of reception and humanization, in addition to an interdisciplinary and intersectoral scope. physical sexual psychological harm complaintsanxieties complaints anxieties complaints/anxieties review Scopus PubMed CINAHL Science LILACS 2023 headings retrieved analyses problem education policies humanization scope 202 20 2

Resumo A violência direcionada à mulher é definida como todo ato resultante das relações de gênero que cause morte, dano físico, sexual, psicológico, patrimonial e moral. O cuidado integral possibilita que o profissional conheça a rede de apoio, a fim de orientá-las e encaminhá-las aos serviços, e valorize queixas/anseios. Objetivou-se identificar a produção científica acerca do cuidado integral às mulheres vítimas de violência. Trata-se de uma revisão integrativa da literatura. A coleta de dados ocorreu com busca pareada e independente de duas pesquisadoras, nos bancos Scopus, PubMed, CINAHL, Web of Science, LILACS, BDENF e SciELO, no período de janeiro e fevereiro de 2023. Foram utilizados critérios de elegibilidade, Descritores em Ciências da Saúde e Medical Subject Headings, totalizando dez artigos. Na análise dos dados, utilizou-se o software Iramuteq. Verificou-se grandes desafios para o cuidado integral, e que a violência contra a mulher, por ser uma problemática social grave, demanda políticas de saúde, educação, assistência social e segurança pública. Conclui-se que as ações integrais no cuidado à mulher vítima de violência demonstram forte vínculo com as práticas de acolhimento, humanização, além de perpassarem o âmbito interdisciplinar e intersetorial. morte físico sexual psicológico moral apoio orientálas orientá las encaminhálas encaminhá serviços queixasanseios queixas anseios queixas/anseios Objetivouse Objetivou se Tratase Trata literatura pesquisadoras Scopus PubMed CINAHL Science LILACS SciELO 2023 elegibilidade Headings artigos utilizouse utilizou Iramuteq Verificouse Verificou grave saúde educação pública Concluise Conclui acolhimento humanização intersetorial 202 20 2

Abstract Luffa operculata (L.) Cogn. (Cucurbitaceae) aqueous extract (EBN) was gestationally administered to Wistar rats to evaluate sex-related behavioral changes in young individuals receiving a two-hit stimulus of 1 mg/kg EBN, followed by stress challenge (NYM) or lipopolysaccharide (LPS) exposure. EBN exposition occurred by gavage at gestational days (GDs) 17 to 21, and NYM or LPS was conducted at post-natal day 60 (PND60). Behavior was evaluated in the open field (OF) and light-dark box (LDB) apparatuses. Serum hormones, pro- inflammatory cytokines, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and creatinine were measured. The liver and kidneys were histologically evaluated. Male and female young rats responded differently in latency to the light side and locomotion frequency on the dark side, corticosterone (females, LPS), and ACTH (females, stress). Male rats showed improved TNF-α (LPS group) and melatonin (LPS group). No histological or biochemical differences were observed in the liver or kidneys. Female young rats were more resilient to the two-hit-stimulus than the male rats. The gestational administration of EBN to male and female Wistar rats and a second stimulus (stress challenge or LPS exposure) at a young age allowed for discriminating differences in behavior, stress hormones, and cytokines according to the sex of the rat. However, no histological alterations in the liver or kidneys were observed, nor in the AST, ALT, or creatinine levels. L. L (L. Cogn Cucurbitaceae (Cucurbitaceae (EBN sexrelated related twohit two hit mgkg mg kg (NYM exposure GDs (GDs 21 postnatal post natal 6 PND60. PND60 PND . (PND60) OF (OF lightdark LDB (LDB apparatuses hormones pro AST , (AST) ALT (ALT) measured females, females (females LPS, LPS) stress. stress) TNFα TNF α group group. twohitstimulus behavior rat However levels (L 2 PND6 (PND60 (AST (ALT (PND6 (PND