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[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Data de publicação: 2024-04-08

Resumo: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Surface Modification of the Ti25Ta25Nb3Sn Alloy and its Influence on The Cell and Bacteria Adhesion - In Vitro Studies
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Souza, Marisa A.

; Lima, Marcia C. M.

; Escada, Ana L. A.

; Pimentel, Bruna N. A. S.

; Vergani, Carlos E.

; Sabino, Roberta M.

; Popat, Ketul C.

; Alves, Ana P. Rosifini

Materials Research

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2023, Volume 26 elocation e20230113

Resumo: En | Texto: En | PDF: En

In this study, alkaline treatment was used to change the surface of the new beta titanium alloy Ti25Ta25Nb3Sn and enhance its bioactivity. Ti25Ta25Nb3Sn, a new experimental alloy was processed in the laboratory and the surfaces were modified using alkaline treatment. Samples were soaked at 60 0C for 24 hours in different NaOH solutions to obtain surfaces with different morphologies. The surfaces were characterized by different techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM), and Atomic Force Microscopy (AFM). The wettability of the surfaces was measured using the sessile drop method. In vitro studies were carried out to evaluate cell adhesion, proliferation, and bacteria adhesion. As a result of the alkaline treatment, a nanoporous and amorphous layer was formed on the Ti25Ta25Nb3Sn alloy surface with super hydrophilic behavior for all conditions evaluated. However, different nano topography was observed which affected biological response. The morphology obtained after immersion in 1.5 NaOH solution led to bacteria adhesion decreased and osteoblasts cells differentiation. Results of this study show that is possible to obtain a new titanium experimental alloy with excellent bulk and surface properties that may decrease the risk of infections and increase osseointegration.

https://doi.org/10.1590/1980-5373-mr-2023-0113

Growth and longevity of the freshwater prawn Macrobrachium brasiliense (Decapoda: Palaemonidae)
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Nogueira, Caio S.

; Porto, Ana Carolina F.

; Barros-Alves, Samara P.

; Jacobucci, Giuliano B.

; Almeida, Ariádine C.

Revista mexicana de biodiversidad

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2022, Volume 93 elocation e933751

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen En el presente estudio se analizaron los parámetros de crecimiento y longevidad de machos y hembras de Macrobrachium brasiliense. Las muestras se obtuvieron mensualmente desde julio/2012 hasta junio/2013 en la región de Triângulo Mineiro, Minas Gerais, Brasil. Un total de 199 camarones adultos (97 machos, 102 hembras) fueron analizados y medidos según la longitud del caparazón (CL, mm). Los machos (9.64 ± 4.17 mm, CL) fueron más grandes que las hembras (7.7 ± 3.39 mm, CL). Las curvas de crecimiento para CL por el modelo de von Bertalanffy se describen mediante las ecuaciones: CL = 21.0 [1 - e -0.00446 (t)] para los machos y CL = 20.0 [1 - e -0.00454 (t)] para las hembras. Al comparar las curvas de crecimiento con la prueba tipo F, no hubo diferencias entre los coeficientes de crecimiento (K) de machos y hembras (GL22; F3.16 = 2.476; p = 0.088). La longevidad se estimó en 2.83 años para los machos y 2.78 años para las hembras. En general, la longevidad observada es similar a la de las especies de Macrobrachium.

Abstract Growth and longevity parameters of males and females of Macrobrachium brasiliense were analyzed. Sampling was carried out monthly from July 2012 to June 2013 in Triângulo Mineiro region, Minas Gerais, Brazil. A total of 199 adult prawns (97 males and 102 females) were analyzed and measured according to the carapace length (CL, mm). Males (9.64 ± 4.17 mm, CL) were larger than females (7.7 ± 3.39 mm, CL). CL growth curves by the von Bertalanffy model are described by the equations CL = 21.0 [1 - e -0.00446 (t)] for males and CL = 20.0 [1 - e -0.00454 (t)] for females. Comparison of the growth curves by performing the F-type test, showed that there was no difference between the growth coefficients (K) of males and females (GL22; F3.16 = 2.476; p = 0.088). Longevity was estimated as 2.83 years for males and 2.78 years for females. In general, the observed longevity is similar to that of other Macrobrachium species.

https://doi.org/10.22201/ib.20078706e.2022.93.3751

Classification of homogeneous regions of vegetation cover in the State of Rio Grande do Sul, Brazil and its temporal dynamics, using AVHRR GIMMS and MODIS data sets
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CORDEIRO, ANA PAULA A.

; ALVES, RITA DE CÁSSIA M.

; STEFFLER, ANA PAULA L.W.

; MENGUE, VAGNER P.

; FONTANA, DENISE C.

; ROGLIO, VINICIUS S.

; GUASSELLI, LAURINDO A.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 Nº 3 elocation e20201278

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to classify the homogeneous regions of vegetation cover, which occur in Rio Grande do Sul, formed by clustering of pixels with same pattern of temporal variability of the Normalized Difference Vegetation Index (NDVI) of AVHRR GIMMS and MODIS series and to compare their temporal dynamics. We use K means cluster analysis for defining homogeneous regions, based on the temporal variability of GIMMS (8 km spatial resolution) and MODIS (1 km spatial resolution) NDVI data sets, using monthly images mean from 2000 to 2008 (overlapping period); and we analyzed the annual pattern of NDVI. Accuracy assessment was done with Landsat images. The results show that the temporal variability of GIMMS and MODIS NDVI allows to delimit similar homogeneous regions in order to mapping the main vegetation cover. MODIS series shows a greater detail in the definition of the regions, but with compatibility with those generated by GIMMS. The temporal dynamics show a typical seasonal pattern, with variations of NDVI amplitude between the groups, that allow to monitor phenological changes. The deviations from calibration between times series are linear, which would facilitate a correction in order to construct a long synthetic time series for studies of land cover change.

https://doi.org/10.1590/0001-3765202120201278 134 downloads

Titanium-Tantalum Alloy Surface Modification by Hydroxyapatite Layer on TiO2 Nanotubes: Effect on Microbial Activity
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Capellato, Patricia

; Vasconcelos, Lucas V. B.

; Vilela, Filipe B.

; Ribeiro, Gilza Carla

; Correia, Cristiane A. P.

; Silva, Gilbert

; Sachs, Daniela

; Rangel, André L. R.

; Zavaglia, Cecilia A. de C.

; Claro, Ana P. R. Alves

Materials Research

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2021, Volume 24 Nº 6 elocation e20210285

Resumo: En | Texto: En | PDF: En

Abstract One of the major health security challenges of the 21st century is the occurrence of microbial infections and bacterial complications that could affect 10 million people by 2050. On the biomaterial field, implant metallic currently replaces partial or total body parts and can fail to be integrated into the body due to infections. This study performs two combined surface modifications on Ti-30Ta alloy, in order to obtain an infection-resistance and osseointegration surface on metallic implants to be tested within bacterial biofilm. The Group 1 investigated surface modifications by the anodization process in the electrolyte glycerol + NH4F 0.25% at 30V- 9 hours and annealed in 530°C (5°C/min). The Group 2 underwent the same process as Group 1 and, additionally, the samples were immersed in 0.3 M CaCl2 and 0.5 M Na2HPO4 solutions for hydroxyapatite growth. The substrate was characterized using scanning electron microscopy (SEM), X-ray diffractometer (XRD) and dynamic contact angle. S. epidermidis bacterial adhesion and biofilm formation. The results indicated that the Group 1 shows a higher antimicrobial activity, hydrophilic behavior and potential to be used for metallic implant applications. The Group 2 with the hydroxyapatite film coating did not have an improvement in the antimicrobial response.

https://doi.org/10.1590/1980-5373-mr-2021-0285 33 downloads

Theoretical and Experimental Investigations on Inclusion Complex β-Cyclodextrin and Sulcatone: A Cardiovascular Activity Evaluation
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Silva, Ivan S.

; Feitosa, Eduardo L.

; Santos, Márcio E. P.

; Silva, Raiane M.

; Rocha, Márcio S.

; Silva, Francisco I. da

; Lima, Francisco C. A.

; Costa, Ana Maria S.

; Alves, Péricles B.

; Sousa, Samuel A. A. de

; Oliveira, Aldeídia P.

; Lima, Sidney G. de

Journal of the Brazilian Chemical Society

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Mai 2020, Volume 31 Nº 5 Páginas 1064 - 1077

Resumo: En | Texto: En | PDF: En

In this paper, we have applied state-of-the-art technologies and new investigations were developed focusing on obtaining simple and inexpensive molecules for treating cardiovascular diseases, as they are considered the leading cause of death in the world. For the first time, the inclusion complex of sulcatone (SU) and β-cyclodextrin (β-CD) was achieved (using a spray drier) and characterized making use of spectroscopic, thermal and computational methods. In addition, the system was evaluated regarding its vasorelaxant properties. Evidence of the inclusion complex formation was provided using different techniques, such as X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), and 1H nuclear magnetic resonance (NMR) spectroscopies and then deduced by pharmacological experiments, which showed significant changes in relation to the initial material.

https://doi.org/10.21577/0103-5053.20190273 403 downloads

Exercise Training Improves Heart Rate Recovery after Exercise in Hypertension
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Amaro-Vicente, Graziela

; Laterza, Mateus C.

; Martinez, Daniel G.

; Alves, Maria Janieire N. N.

; Trombetta, Ivani C.

; Braga, Ana Maria F. W.

; Toschi-Dias, Edgar

; Rondon, Maria Urbana P. B.

Motriz: Revista de Educação Física

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2019, Volume 25 Nº 1 elocation e101902

Resumo: En | Texto: En | PDF: En

Abstract Aim: This study tested the hypothesis that: 1- the exercise training would improve the heart rate recovery (HRR) decline after maximal exercise test in hypertensive patients and; 2- the exercise training would normalize HRR decline when compared to normotensive individuals. Methods: Sixteen hypertensive patients were consecutively allocated into two groups: Exercise-trained (n = 9, 47±2 years) and untrained (n = 7, 42±3 years). An exercise-trained normotensive group (n = 11, 41±2 years) was also studied. Heart rate was evaluated by electrocardiogram. The autonomic function was evaluated based on heart rate changes on the first and the second min of recovery after the maximal exercise test. Exercise training consisted of three 60-minute exercise sessions/week for 4 months. Results: In hypertensive patients, exercise training significantly increased the HRR decline in the first (-19±2 vs. -34±3 bpm, P = 0.001) and second (-33±3 vs. -49±2 bpm, P = 0.006) minutes after the maximal exercise test. In addition, after exercise training, the initial differences in the HRR decline after exercise between hypertensive patients and normotensive individuals were no longer observed (first minute: -34±3 vs. -29±3 bpm, P = 0.52, and second minute: -49±2 vs. -47±4 bpm, P = 0.99). Conclusion: Hypertension causes a delay in HRR after the maximal exercise test yet the exercise training normalizes HRR during the post-exercise period in hypertensive patients.

https://doi.org/10.1590/s1980-6574201900010021 1361 downloads

Evaluation of the Chemical Composition of Dry Feeds for Dogs and Cats
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Costa, Silvânio S. L.

; Pereira, Ana C. L.

; Passos, Elisangela A.

; Alves, José P. H.

; Garcia, Carlos A. B.

; Araujo, Rennan G. O.

Journal of the Brazilian Chemical Society

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Dez 2018, Volume 29 Nº 12 Páginas 2616 - 2625

Resumo: En | Texto: En | PDF: En

Cat and dog feed production has increased worldwide, and much emphasis has been placed on the importance of determining the mineral composition of pet foods. In this work, the concentrations of Al, Ba, Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Ni, P, Sr, V and Zn in dry feed for cats and dogs employing inductively coupled plasma-optical emission spectrometry (ICP OES) were determined and evaluated according to regulatory agencies. Forty-one dry feed samples (24 dog feed and 17 cat feed) were analyzed. The obtained concentrations ranged from 2.3 mg kg-1 (Ba) to 2.8 g kg-1 (Ca) in cat feeds, and from 3.8 mg kg-1 (Cu) to 3.4 g kg-1 (Ca) in dog feeds. The concentrations of P are in accordance with the Brazilian legislation, and Mn and Zn contents met the American legislation. The concentration values of Cu, K and Mg presented in some samples were below the limits established by American regulatory agency. Based on multivariate data analysis evaluated from flavors of the products and brands, it was concluded that the feed samples were uniform since there was no trend to group formation and classification according to their mineral composition, except one dog feed brand, which had a significant content of Al and Cu.

https://doi.org/10.21577/0103-5053.20180142 712 downloads

Adherence to and invasion of HeLa cells by Campylobacter spp. strains isolated from animals
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Morais-Rios, Paula Alexandra G.

; Alves, Telma M.

; Dorneles, Elaine M.S.

; Stynen, Ana Paula R.

; Cottorello, Ana Cláudia P.

; Lauria-Filgueiras, Ana Luzia

; Lage, Andrey P.

Pesquisa Veterinária Brasileira

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Jul 2018, Volume 38 Nº 7 Páginas 1293 - 1299

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste estudo foi avaliar a adesão e invasão de células HeLa por amotras de Campylobacter spp. (total n=63) isoladas de frangos (n=4), cães (n=4), primatas não-humanos (n=16), porcos (n=9), fezes de bezerros (n=18), e trato genital de bovinos (n=12). Trinta e duas amostras foram capazes de aderir e 13 invadiram células HeLa. As amostras invasivas incluíram 1 de 4 isolados de cão, 4 de 16 isolados de primatas não-humano (2 C. jejuni e 2 C. coli), 1 de 9 C. coli isoladas de porcos e 7 de 18 C. fetus subsp. fetus isoladas de fezes de bezerros. Apenas 25% dos isolados de frango e de cão e 23% dos isolados de suínos foram capazes de aderir a células HeLa, propriedade exibida por 65% das cepas obtidas a partir de fezes de bezerros e por 83% das amostras isoladas de trato genital bovino. O fenótipo aderente foi observado em 5 de 19, 6 de 15 e 21 de 29 amostras de C. jejuni, C. coli e C. fetus subsp. fetus, respectivamente, enquanto que 3 de 19, 3 de 15 e 7 de 29 amostras foram adicionalmente capazes de invadir as células HeLa, respectivamente. Amostras de C. jejuni, C. coli e C. fetus subsp. fetus isoladas de fezes de animais foram capazes de aderir e invadir as células HeLa, enquanto amostras de C. fetus subsp. fetus isoladas a partir de amostras de trato genital bovino não foram invasivas, em células HeLa. O presente estudo mostrou que amostras de C. jejuni isoladas de primatas não-humanos e cães, C. coli isoladas de primatas não-humanos e porcos, e C. fetus subsp. fetus isolados a partir de fezes de bezerros foram capazes de aderir e invadir células HeLa. Além disso, a falta de capacidade invasiva de amostras de C. fetus subsp. fetus isoladas de trato genital bovino pode ser importante na patogênese das doenças das vias genitais causadas por esta bactéria.

ABSTRACT: The objective of this study was to evaluate the adherence to and invasion of HeLa cells by Campylobacter spp. strains (total n=63) isolated from chickens (n=4), dogs (n=4), non-human primates (n=16), pigs (n=9), calf feces (n=18), and bovine genital tracts (n=12). Thirty-two strains adhered to and 13 invaded HeLa cells. Invasive strains included 1 of 4 dog isolates, 4 of 16 non-human primate isolates (2 C. jejuni and 2 C. coli), 1 of 9 C. coli strains isolated from pigs, and 7 of 18 C. fetus subsp. fetus isolated from calf feces. Only 25% of chicken and dog isolates and 23% of pig isolates were able to adhere to HeLa cells, a property of 65% of strains obtained from calf feces and 83% of bovine genital tract-isolated strains. The adherent phenotype was observed in 5 of 19, 6 of 15, and 21 of 29 strains of C. jejuni, C. coli, and C. fetus subsp. fetus, respectively, whereas 3 of 19, 3 of 15, and 7 of 29 strains were additionally able to invade HeLa cells, respectively. C. jejuni, C. coli, and C. fetus subsp. fetus strains isolated from animal feces are able to adhere and invade HeLa cells, whereas C. fetus subsp. fetus strains isolated from the bovine genital tract were not invasive in HeLa cells. The present study showed that C. jejuni isolated from primates and dogs, C. coli isolated from non-human primates and pigs, and C. fetus subsp. fetus isolated from calf feces have the ability to adhere to and to invade HeLa cells. Moreover, the lack of invasive ability by C. fetus subsp. fetus strains isolated from the bovine genital tract could be important in the pathogenesis of the genital tract diseases caused by this bacterium.

https://doi.org/10.1590/1678-5150-pvb-4999 724 downloads

10.

Brazilian legislation on genetic heritage harms Biodiversity Convention goals and threatens basic biology research and education
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ALVES, RUY JOSÉ V.

; WEKSLER, MARCELO

; OLIVEIRA, JOÃO A.

; BUCKUP, PAULO A.

; POMBAL JR., JOSÉ P.

; SANTANA, HÉLCIO R.G.

; PERACCHI, ADRIANO LÚCIO

; KELLNER, ALEXANDER W.A.

; ALEIXO, ALEXANDRE

; LANGGUTH, ALFREDO

; ALMEIDA, ALZIRA MARIA P. DE

; ALBERNAZ, ANA LUISA

; RIBAS, CAMILA C.

; ZILBERBERG, CARLA

; GRELLE, CARLOS EDUARDO V.

; ROCHA, CARLOS F.D.

; LAMAS, CARLOS JOSÉ E.

; HADDAD, CÉLIO F.B.

; BONVICINO, CIBELE R.

; PRADO, CYNTHIA P.A.

; LIMA, DANIELA O. DE

; ROSSA-FERES, DENISE C.

; SANTOS, FABRÍCIO R. DOS

; SALIMENA, FÁTIMA REGINA G.

; PERINI, FERNANDO A.

; BOCKMANN, FLÁVIO A.

; FRANCO, FRANCISCO LUÍS

; GIUDICE, GISELE M.L. DEL

; COLLI, GUARINO R.

; VIEIRA, IMA CÉLIA G.

; MARINHO-FILHO, JADER

; WERNECK, JANE M.C.F.

; SANTOS, JORGE A.D. DOS

; NASCIMENTO, JORGE LUIZ DO

; NESSIMIAN, JORGE LUIZ

; CORDEIRO, JOSÉ LUIS P.

; CLARO, KLEBER DEL

; SALLES, LEANDRO O.

; CASATTI, LILIAN

; PY-DANIEL, LUCIA HELENA R.

; SILVEIRA, LUÍS FÁBIO

; TOLEDO, LUÍS FELIPE

; OLIVEIRA, LUIZ F. DE

; MALABARBA, LUIZ ROBERTO

; SILVA, MARCELO D. DA

; COURI, MÁRCIA S.

; MARTINS, MÁRCIO

; TAVARES, MARCOS D.S.

; SOBRAL, MARCOS EDUARDO G.

; VIEIRA, MARCUS VINÍCIUS

; OLIVEIRA, MARIA DE LOURDES A.

; PINNA, MÁRIO DE

; HOPKINS, MICHAEL J.G.

; SOLÉ, MIRCO

; MENEZES, NAÉRCIO A.

; PASSOS, PAULO

; D’ANDREA, PAULO SERGIO

; PINTO, PEDRO C.E.A.

; VIANA, PEDRO L.

; TOLEDO, PETER M.

; REIS, ROBERTO E.

; VILELA, ROBERTO

; BASTOS, ROGÉRIO P.

; COLLEVATTI, ROSANE G.

; CERQUEIRA, RUI

; CASTROVIEJO-FISHER, SANTIAGO

; CARAMASCHI, ULISSES

Anais da Academia Brasileira de Ciências

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Abr 2018, Volume 90 Nº 2 Páginas 1279 - 1284

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/0001-3765201820180460 7311 downloads

11.

A detecção eletroquímica da lidocaína sobre o oxihidróxido de cobalto trivalente. Uma possibilidade teórica a ser avaliada
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Tkach, Volodymyr V.

; Ivanushko, Yana G.

; Lukanova, Svitlana M.

; Kushnir, Marta V.

; de Oliveira, Sílvio C.

; Alves, Ana P.

; Ojani, Reza

; Yagodynets', Petró I.

Revista Colombiana de Ciencias Químico - Farmacéuticas

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Abr 2018, Volume 47 Nº 1 Páginas 71 - 85

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Summary The electrochemical behavior of lidocaine during its electrooxidation over trivalent cobalt oxyhydroxide in lightly alkaline medium, realized for electroanalytical purposes, was evaluated from the mechanistic mathematical point of view. From analysis a conclusion has been made of the electroanalytical function of CoO(OH) as an electrode modifier for lidocaine electrooxidation in vivo and in vitro. Also, the possibility of oscillatory and monotonic instabilities has been verified in the system.

RESUMO O comportamento eletroquímico da lidocaína durante a sua eletrooxidação sobre o oxihidróxido de cobalto trivalente em meio levemente básico, realizada para fins eletroanalíticos, foi avaliado do ponto de vista mecanístico matemático. Da análise foi feita uma conclusão acerca do desempenho do CoO(OH) como modificador de elétrodo na eletrooxidação da lidocaína in vivo e in vitro. Foi, outrossim, verificada a possibilidade da realização das instabilidades oscilatória e monotônica no sistema.

https://doi.org/10.15446/rcciquifa.v47n1.70659 316 downloads

12.

Effects of hydroalcoholic extract of Celtis iguanaea on markers of cardiovascular diseases and glucose metabolism in cholesterol-fed rats
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Zanchet, Barbara

; Gomes, Denise B.

; Corralo, Vanessa S.

; Diel, Kriptsan A.P.

; Schönell, Amanda P.

; Faust, Caroline

; Nicola, Patrícia

; Muller, Liz G.

; Zanatta, Ana P.

; Wildner, Silvana M.

; Bevilaqua, Fernanda

; Chitolina, Rafael

; Sachett, Adrieli

; Zanatta, Leila

; Duarte, Marta M.M.F.

; Conterato, Greicy M.M.

; Rocha, Claudia Q.

; Peretti, Camile

; Brumelhaus, Tatiane

; Alves, Nayara S.

; Menegatt, Jean C.O.

; Conte, Fernanda

; Serena, Guilherme

; Ramos, Adriano T.

; Zimermann, Francielli C.

; Roman Junior, Walter A.

Revista Brasileira de Farmacognosia

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Jan 2018, Volume 28 Nº 1 Páginas 80 - 91

Resumo: En | Texto: En | PDF: En

ABSTRACT Celtis iguanaea (Jacq.) Sarg., Cannabaceae, is popularly used in the treatment of diabetes mellitus. However, chemical and pharmacological investigations are lacking. In this study, we investigated the effects of the hydroalcoholic extract from C. iguanaea on markers of cardiovascular diseases and the glucose metabolism in cholesterol-fed rats. Therefore, hypercholesterolemic rats (1% cholesterol) were orally treated with C. iguanaea extract (C-150, CI-300, or CI-600 mg/kg) or simvastatin (4 mg/kg) (n = 6) once a day (30 days) with a hypercholesterolemic diet. A control group (C) was given saline. C. iguanaea extract showed significant decreases in serum levels of total cholesterol, LDL-cholesterol, HMG-CoA-reductase, interleukin-1 and 6, TNF-α and IFN-γ when compared to group C (p < 0.001). Hypoglycemic effects were observed along with a decrease of the activity of sucrase (CI-600), maltase (CI-150, CI-300), and an increase in muscle glycogen levels (CI-300). Antioxidant effects were observed in plasma by the decrease of TBARS and increase of nonprotein thiols levels (CI-600). The histopathological analysis showed a significant decrease in the liver fat area for C. iguanaea extract compared to group C (p < 0.001). Our results suggest that the biological effects of C. iguanaea extract could be related to the flavonoids that possibly exert antioxidant, enzymatic inhibitory, and insulin-mimetic effects.

https://doi.org/10.1016/j.bjp.2017.12.001 731 downloads

13.

FRUIT FLIES AND THEIR PARASITOIDS IN THE FRUIT GROWING REGION OF LIVRAMENTO DE NOSSA SENHORA, BAHIA, WITH RECORDS OF UNPRECEDENTED INTERACTIONS
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LEITE, SUZANY AGUIAR

; CASTELLANI, MARIA APARECIDA

; RIBEIRO, ANA ELIZABETE LOPES

; COSTA, DANIELA RIBEIRO DA

; BITTENCOURT, MARIA APARECIDA LEÃO

; MOREIRA, ALDENISE ALVES

Revista Brasileira de Fruticultura

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2017, Volume 39 Nº 4 elocation e-592

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Várias espécies de moscas frugívoras (Diptera: Tephritidae e Lonchaeidae) assumem o status de pragas primárias em fruteiras cultivadas no Brasil, determinando prejuízos diretos à produção. O objetivo do trabalho foi conhecer aspectos da diversidade de moscas frugívoras e seus parasitoides no polo de fruticultura de Livramento de Nossa Senhora-BA. Foram realizadas amostragens de frutos em 19 espécies vegetais durante novembro/2011 e junho/2014. Foram calculados os índices de infestação em pupário.kg-1 de fruto e pupário.fruto-1. Os resultados indicaram a ocorrência de Anastrepha obliqua (Macquart), Ceratitis capitata (Wiedemann) e Neosilba pendula (Bezzi). As espécies vegetais Anacardium occidentale, Averrhoa carambola, Carica papaya, Eugenia uniflora, Malpighia emarginata, Mangifera indica var. “Haden”, “Rosa” e “Tommy Atkins”, Opuntia ficus indica, Pereskia bahiensis, Psidium guajava, Spondias lutea, Spondias purpurea e Spondias tuberosa são hospedeiros de moscas frugívoras na região. Registram-se, as relações bitróficas inéditas entre P. bahiensis e C. capitata e Anastrepha sp.; e entre Opuntia fícus indica e C. capitata e Anastrepha obliqua. Registra-se a relação tritrófica inédita para o Estado da Bahia A. carambola e C. capitata e parasitoide da Família Pteromalidae. Foram contatadas, também, as associações tritróficas entre M. indica var. “Tommy Atkins” e S. purpurea e A. obliqua e Doryctobracon areolatus; e entre S. purpurea e A. obliqua e Utetes anastrephae.

ABSTRACT Several fruit fly species (Diptera: Tephritidae and Lonchaeidae) assume the status of primary pests in fruit trees grown in Brazil, causing direct production losses. The aims of the study were to know aspects of diversity of fruit flies and their parasitoids in the fruit growing region of Livramento de Nossa Senhora, Bahia. Fruit samples were collected from 19 plant species during November/2011 and June/2014. Infestation rates were calculated in pupae.kg-1 of fruit and pupae.fruit-1. The results indicate the occurrence of Anastrepha obliqua (Macquart), Ceratitis capitata (Wiedemann) and Neosilba pendula (Bezzi). Plant species Anacardium occidentale, Averrhoa carambola, Carica papaya, Eugenia uniflora, Malpighia emarginata, Mangifera indica var. “Haden”, “Rosa” and “Tommy Atkins”, Opuntia ficus indica, Pereskia bahiensis, Psidium guajava, Spondias lutea, Spondias purpurea and Spondias tuberosa are hosts of fruit flies in the region. Unprecedented bitrophic relationships between P. bahiensis and C. capitata and Anastrepha sp. and between Opuntia ficus indica and C. capitata and A. obliqua were recorded. Unprecedented tritrophic relationship for the state of Bahia Averrhoa carambola and C. capitata and parasitoid of the Pteromalidae Family were also recorded. Tritrophic associations between M. indica var. “Tommy Atkins” and S. purpurea and A. obliqua and Doryctobracon areolatus; and between S. purpurea and A. obliqua and Utetes anastrephae were observed.

https://doi.org/10.1590/0100-29452017592 1256 downloads

14.

Comportamento sexual e estudantes do ensino superior
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Pimentel, Maria Helena

; Preto, Leonel São Romão

; Alves, Maria José Gonçalves

; Monteiro, Ana Margarida P. C.

Psicologia, Saúde & Doenças

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Dez 2016, Volume 17 Nº 3 Páginas 352 - 367

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Nos últimos anos surgiram várias investigações relacionadas com a sexualidade e o grupo dos jovens tem sido privilegiado. Contudo o conhecimento sobre o comportamento dos estudantes do Ensino Superior relativos a esta matéria contínua, em Portugal, insuficiente. Neste contexto surge o interesse pela presente investigação enquadrada na identificação de determinantes de saúde e perfis de risco destes jovens, relacionados com o comportamento sexual. Desenvolveu-se um estudo descritivo-correlacional por questionário a uma amostra estratificada proporcional por curso e escola que integra 272 alunos do sexo masculino (40,5%) e 400 do feminino (59,5%), totalizando 672. A grande maioria é sexualmente ativo (86%) com predomínio do sexo masculino (93%) e com diferenças estatísticas significativas (p<0,001), mais de metade (58%) iniciou a atividade sexual de forma imprevista e 41% de forma planeada. O preservativo é o contracetivo mais utilizado (60,3%) porém 62% dos rapazes declaram não usar qualquer método contracetivo (p<0,001). Constatou-se uma associação significativa entre o maior número de parceiros sexuais e o uso de contraceção (p=0,001) e, por sua vez, entre o maior número de parceiros sexuais e o uso isolado do preservativo ou associado à pílula (p<0,001). 40% das jovens afirmam ter sentido receio de engravidar “uma vez” e 17,5% “mais do que uma vez”, das quais 60% recorreram nos últimos 12 meses à contraceção de emergência. Conclui-se que a informação sobre os riscos inerentes às condutas sexuais deverá constituir-se, neste grupo, uma prioridade de ação.

Several researches on sexual health have been developed along the last past years and young people have been privileged in those studies. However knowledge about the behavior of college students concerning this solid matter in Portugal, insufficient. That´s why we developed the present study aiming to identify health determinants and risk profile among these young people, related to sexual behavior. It was developed a descriptive-correlational study using a sample of 272 male students (40, 5%) and 400 female students (59, 5%) stratified by graduation and school, in 672 students. Most of the students (86%) it has sexual activity and within these the majority were male (93%) with high significant differences of proportions (p<0,001). More than a half (58%) began sexual activity in an unplanned way and 41% had it planned. Condom is the most used method (60, 3%), 62% of the boys declared not to use any kind of contraceptive method (p<0,001) ?ere is a highly significant association between the number of sexual partners and the use of contraceptive methods (p=0,001) and also between the greater number of sexual partners and the use of condom used as the only method or in association with contraceptive pills. 40% of the girls referred that “once” they were afraid of getting pregnant and 17,5% referred that they were afraid “more than once” and from these, 60% used the emergency contraception in the past 12 months. It is concluded that information about the risks involved in sexual behavior should be, in this group, a priority for action.

https://doi.org/10.15309/16psd170304 1975 downloads

15.

A new species of Trileptium (Nematoda: Thoracostomopsidae) from Bahia, Brazil
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Vilas-Boas, Ana C.

; Silva, Maria C. da

; Alves, Orane F. de Souza

; Castro, Francisco J.V. de

; P. Pinheiro-Junior, Eraldo

Zoologia (Curitiba)

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2016, Volume 33 Nº 1 elocation e20150043

Resumo: En | Texto: En | PDF: En

ABSTRACT A new species of a free-living marine nematode found in Brazil is described: Trileptium ribeirensis sp. nov. The type material is deposited in the Nematoda collection of the Museu de História Natural da Bahia, located at the Universidade Federal da Bahia. Trileptium includes eleven valid species of nematodes that have teeth and jaws positioned forward. The species was collected with the help of corers (3.5 cm in diameter and 30 cm long) on a sandy beach in Bahia. This species is distinguished from its congeners based on a combination of characters of the male (cuticle, buccal cavity, supplement and gubernaculum). An updated taxonomic key to the genus is presented.

https://doi.org/10.1590/S1984-4689zool-20150043 2157 downloads

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