This study aimed to isolate, purify and characterize secondary metabolites present in Amburana acreana leaves, native to the state of Rondônia, using classical chromatographic methods and 1D, 2D nuclear magnetic resonance spectroscopy. From the hydroethanolic leaves extract of A. acreana, p-hydroxybenzoic acid, vanillic acid, coumarin, campesterol 3-β-D-glucoside and amburoside B, all known compounds, were identified. To the best of our knowledge, this is the first report of isolation and chemical characterization of secondary metabolites in A. acreana. In addition, in vitro assays indicated that amburoside B does not have inhibitory potential on the growth of gram-negative bacteria. The presence of these compounds suggests that, thus far, amburosides (A and B) could be chemotaxonomic markers of the genus Amburana. isolate Rondônia 1D D spectroscopy A phydroxybenzoic p hydroxybenzoic acid coumarin 3βDglucoside βDglucoside 3 β glucoside identified knowledge addition gramnegative gram negative bacteria far

RESUMO A produção de grãos apresenta crescimento constante, entretanto, a capacidade estatística de armazenamento permanece deficitária no Brasil. A falta de estruturas e a precariedade e inadequação no armazenamento ocasionam perdas na pós-colheita, devido ação de fatores que interagem com os grãos, culminando na sua deterioração. Para reversão desses efeitos, o tratamento químico é realizado, contudo, busca-se por sua substituição por substâncias naturais devido a implicações ambientais e medicinais. Objetivou-se com esta revisão, a discussão de uma potencial estratégia sustentável para o tratamento de grãos armazenados, com foco no uso de compostos naturais com propriedades bioativas como antifúngica, antioxidante e inseticida, que os torna potenciais para serem estudados. Foram delineados compostos naturais que possuem propriedades úteis para aplicação no armazenamento de grãos. Pesquisas a respeito do emprego dos compostos naturais no tratamento de grãos são incipientes, carecendo de avanços na identificação de novos compostos promissores, melhor compreensão dos mecanismos de ação e otimização/desenvolvimento de processos de extração, aplicação e formulação eficazes que viabilizem o futuro uso das substâncias. constante entretanto Brasil póscolheita, póscolheita pós colheita, colheita pós-colheita deterioração efeitos realizado contudo buscase busca se medicinais Objetivouse Objetivou revisão armazenados antifúngica inseticida estudados incipientes promissores otimizaçãodesenvolvimento otimização desenvolvimento extração

ABSTRACT Grain production is steadily increasing; however, the static storage capacity remains inadequate in Brazil. The lack of proper facilities and the precarious and inadequate storage conditions lead to post-harvest losses due to factors interacting with the grains, causing their deterioration. Chemical treatments are commonly used to reverse these effects; however, their replacement with natural substances has been sought due to environmental and human health concerns. The objective of this review was to discuss a sustainable strategy for treating stored grains, focusing on the use of natural compounds with bioactive properties, such as antifungal, antioxidant, and insecticidal activities, with potential for further studies. Natural compounds with useful properties for application in grain storage were outlined. Research on the use of natural compounds in grain treatment is still in its early stages, requiring progress in identifying new promising compounds, understanding the mechanisms of action, and developing and optimizing effective extraction, application, and formulation processes to make the use of these substances viable. increasing however Brazil postharvest post harvest grains deterioration effects concerns antifungal antioxidant activities studies outlined stages action extraction viable

Bredemeyera Willd. is a genus of the Polygalaceae family, occurring in Brazil. This research aims to evaluate the phytochemical and antifungal potential, in vitro and in silico, of Bredemeyera brevifolia extracts. The identification of fatty acids by gas chromatography-mass spectrometry and their quantification by gas chromatography-flame ionization detector showed that palmitic (36.55 mg g−1), margaric (3.66 mg g−1), linolelaidic (108.82 mg g−1), oleic (7.86 mg g−1), stearic (41.11 mg g−1), dihomo-γ-linolenic (85.48 mg g−1), and arachidic (209.00 mg g−1) acids are present in the hexane extract. From the chloroform extract, 1-hydroxy-3,7-dimethoxyxanthone was isolated and identified. The minimum inhibitory concentration assay with methanolic extract demonstrated antifungal activity against species of the genus Candida, Sporothrix, and Trichophyton for up to 96 h, with values ranging from 64-1024 μg mL−1. The in silico study with the chemical compounds of this species showed fungal inhibition potential of sterol-14-α-demethylase, highlighting 1-hydroxy-3,7-dimethoxyxanthone, which presented an affinity energy of -8.8 kcal mol−1, greater than that observed for fluconazole (−8.3 kcal mol−1). The fatty acids interacted with the active site of the enzyme but presented energies ≥ −7.4 kcal mol−1. Compounds isolated from this species have pharmacokinetic potential for the development of pharmaceutical formulations. Willd family Brazil extracts chromatographymass chromatography mass chromatographyflame flame 36.55 3655 36 55 (36.5 g−1, g1 g g−1 , 1 3.66 366 3 66 (3.6 108.82 10882 108 82 (108.8 7.86 786 7 86 (7.8 41.11 4111 41 11 (41.1 dihomoγlinolenic dihomo γ linolenic 85.48 8548 85 48 (85.4 209.00 20900 209 00 (209.0 1hydroxy3,7dimethoxyxanthone 1hydroxy37dimethoxyxanthone hydroxydimethoxyxanthone hydroxy 3,7 dimethoxyxanthone identified Candida Sporothrix 9 h 641024 64 1024 64-102 mL1 mL mL−1 sterol14αdemethylase, sterol14αdemethylase sterolαdemethylase sterol 14 α demethylase, demethylase sterol-14-α-demethylase 1hydroxy3,7dimethoxyxanthone, dimethoxyxanthone, 8.8 88 8 -8. mol1 mol mol−1 −8.3 83 (−8. . mol−1) 74 4 −7. formulations 36.5 365 5 (36. g− 3.6 6 (3. 108.8 1088 10 (108. 7.8 78 (7. 41.1 411 (41. 85.4 854 (85. 209.0 2090 20 0 (209. 1hydroxy3 7dimethoxyxanthone 37 3, 64102 102 64-10 mL− αdemethylase 8. -8 mol− −8. (−8 −7 36. (36 3. (3 108. (108 7. (7 41. (41 85. (85 209. 2 (209 1hydroxy 6410 64-1 - −8 (− − ( (10 (4 (8 (20 641 64- (1 (2

RESUMO O objetivo deste estudo foi identificar as fases de plastocrono em cultivares de soja com hábito de crescimento determinado e indeterminado. Os experimentos foram conduzidos no período de 2010/2011 a 2022/2023 em quatro locais do estado do Rio Grande do Sul, Brasil, com 25 cultivares de soja com hábito de crescimento determinado (6) e indeterminado (19). Este estudo buscou dividir o plastocrono em fases durante o período de emissão de nós da soja. Em cultivares irrigadas de hábito de crescimento determinado, o plastocrono apresenta duas fases, a fase inicial de 59,7 °C dia nó-1 e a fase final de 65,7 °C dia nó-1. Em ambientes não irrigados, não há diferença entre as fases inicial e final do plastocrono. As cultivares de hábito de crescimento indeterminado com irrigação apresentam um plastocrono médio inicial e final de 64,1 °C dia nó-1, ao contrário da fase intermediária onde o plastocrono é de 58,5 °C dia nó-1. Em ambientes de sequeiro, as fases inicial e intermédia têm um valor médio de 60,6 °C dia nó-1, ao contrário da fase final com um plastocrono de 79,4 °C dia nó-1. A divisão do plastocrono em fases durante o período de emissão de nós na cultura da soja, proposta neste estudo, permite-nos melhorar o entendimento do desenvolvimento vegetativo de cultivares de soja de hábito de crescimento determinado e indeterminado e estabelecer bases ecofisiológicas para a construção de uma função cronológica. 20102011 2010 2011 2010/201 20222023 2022 2023 2022/202 Sul Brasil 2 6 (6 19. 19 . (19) 597 59 7 59, C nó1 nó 1 nó- 657 65 65, nó1. 1. irrigados 641 64 64, nó1, 1, 585 58 5 58, sequeiro 606 60 60, 794 79 4 79, permitenos permite nos cronológica 2010201 201 2010/20 2022202 202 2022/20 ( (19 201020 20 2010/2 202220 2022/2 (1 20102 2010/ 20222 2022/

ABSTRACT The aim of this study was to identify plastochron phases in soybean cultivars with determinate and indeterminate growth habits. Experiments were conducted from 2010/2011 to 2022/2023 at four locations in Rio Grande do Sul state (RS), Brazil, using 25 soybean cultivars with determinate (6) and indeterminate (19) growth habits. This study divided the plastochron into phases during the soybean node emission stage. In irrigated cultivars with a determinate growth habit, the plastochron has an early and late phase of 59.7 and 65.7 °C day node-1, respectively. In rainfed (non-irrigated) environments, there is no difference between the early and late plastochron phases. The early and late plastochrons of irrigated cultivars with an indeterminate growth habit are 64.1 °C day node-1, while the intermediate phase is 58.5 °C day node-1. In rainfed environments, the average value of the early and intermediate phases is 60.6 °C day node-1, with a late plastochron of 79.4 °C day node-1. Dividing the plastochron into phases during node emission, as proposed in this study, improves understanding of vegetative development in soybean cultivars with determinate and indeterminate growth habits and establishes ecophysiological foundations for chronological function construction. 20102011 2010 2011 2010/201 20222023 2022 2023 2022/202 RS, RS , (RS) Brazil 2 6 (6 19 (19 stage 597 59 7 59. 657 65 65. C node1, node1 1, 1 node-1 respectively nonirrigated non (non-irrigated environments 641 64 64. 585 58 5 58. node1. 1. 606 60 60. 794 79 4 79. construction 2010201 201 2010/20 2022202 202 2022/20 (RS ( (1 node- 201020 20 2010/2 202220 2022/2 20102 2010/ 20222 2022/

Abstract Objective To compare the phase angle (PhA) through bioelectrical impedance (BIA) of children with intestinal failure (IF) using prolonged parenteral nutrition (PN) followed by an Intestinal Rehabilitation Program, with a control group. Methods Children under 10 years of age with IF using prolonged PN for >60 days (study group) were included. The control group consisted of healthy children without chronic pathologies, matched by sex and age. Anthropometric parameters evaluated were: weight, height, weight/age z-score (W/A), height/age z-score (H/A), BMI, BMI/A z-score, arm circumference, triceps skinfold, subscapular skinfold, mid-arm muscle circumference. BIA parameters were resistance (R), reactance (Xc), and phase angle (PhA). Results Twenty-eight children were included in the study group, median (IQR) age was 11 (8-27) months, 53.6 % were male. In the control group, 28 children were included, median (IQR) age was 12.5 (8-24.7) months, 50 % were male. Children from the study group had W/A z-scores and H/A z-scores significantly lower than controls. There was no significant difference between PhA in the study group and controls, [median (IQR) 4.3° (3.8;4.6) vs 4.0° (3.8;5.4) respectively, p = 0.980]. Prematurity was significantly higher in the study group than in the controls, but there was no significant correlation between gestational age at birth and PhA of the children from the study group. Conclusion Children with IF using prolonged PN showed lower W/A and H/A compared to the control group, but without significant difference between the PhA of children with IF compared to controls. (PhA (BIA (IF (PN Program 1 60 >6 pathologies weight height weightage zscore z score W/A, WA , W A (W/A) heightage H/A, HA H (H/A) BMI BMIA zscore, score, circumference skinfold midarm mid R, R (R) Xc, Xc (Xc) PhA. . Twentyeight Twenty eight IQR (IQR 827 8 27 (8-27 months 536 53 6 53. male 2 125 12 5 12. 824.7 8247 24.7 24 7 (8-24.7 zscores scores controls 43 4 3 4.3 3.84.6 3846 3.8 4.6 (3.8;4.6 40 0 4.0 3.85.4 3854 5.4 (3.8;5.4 respectively 0.980. 0980 0.980 980 0.980] > (W/A (H/A (R (Xc 82 (8-2 824 824. 247 24. (8-24. 4. 84 3.84. 384 38 3. 46 (3.8;4. 85 3.85. 385 54 5. (3.8;5. 098 0.98 98 (8- (8-24 3.84 (3.8;4 3.85 (3.8;5 09 0.9 9 (8 (3.8; 0. ( (3.8 (3. (3

Resumo Fundamento: A Cardiomiopatia Chagásica Crônica (CCC) é causada por um processo inflamatório induzido pelo Trypanosoma cruzi, que leva à miocardite com fibrose reativa e reparativa. A CCC progride com alterações de perfusão miocárdica e eventos histopatológicos que afetam a Aptidão Cardiorrespiratória (ACR). Objetivos: Avaliamos os efeitos do Treinamento Físico Aeróbico (TFA) na perfusão miocárdica e nos comprometimentos morfológicos e funcionais relacionados à inflamação e fibrose em hamsters sírios com CCC. Como objetivo secundário, analisamos as áreas de secção transversa do músculo esquelético. Métodos: Hamsters com CCC e seus respectivos controles foram divididos em quatro grupos: CCC sedentário, CCC-TFA, controle sedentário e controle TFA. Sete meses após a infecção, os animais foram submetidos à ecocardiografia, à cintilografia de perfusão miocárdica e ao teste de esforço cardiopulmonar. TFA de intensidade moderada foi realizado durante cinquenta minutos, cinco vezes por semana, por oito semanas. Posteriormente, os animais foram reavaliados. A análise histopatológica foi realizada após os procedimentos acima mencionados. O nível de significância foi estabelecido em 5% em todas as análises (p<0,05). Resultados: Animais com CCC sedentários apresentaram piores Defeitos de Perfusão Miocárdica (DPM) ao longo do tempo, Fração de Ejeção do Ventrículo Esquerdo (FEVE) reduzida, e apresentaram mais inflamação e fibrose quando comparados aos demais grupos (análise ANOVA mista). Por outro lado, o TFA foi capaz de mitigar a progressão do DPM, atenuar a inflamação e a fibrose e melhorar a eficiência da ACR em animais CCC-TFA. Conclusão: Nosso estudo demonstrou que o TFA melhorou a disfunção cardíaca, DPM e reduziu a inflamação e a fibrose em modelos de hamster com CCC. Além disso, os animais CCC-SED apresentaram atrofia do músculo esquelético, enquanto os animais CCC-TFA apresentaram a AST do músculo esquelético preservada. Compreender os efeitos da TFA nas dimensões fisiopatológicas da CCC é crucial para futuras pesquisas e intervenções terapêuticas. Fundamento (CCC cruzi reparativa ACR. . (ACR) Objetivos (TFA secundário Métodos CCCTFA, CCCTFA TFA, infecção ecocardiografia cardiopulmonar minutos semana semanas Posteriormente reavaliados mencionados 5 p<0,05. p005 p p<0,05 0 05 (p<0,05) Resultados (DPM tempo FEVE (FEVE reduzida mista. mista mista) lado CCCTFA. Conclusão cardíaca disso CCCSED SED preservada terapêuticas (ACR p00 p<0,0 (p<0,05 p0 p<0, (p<0,0 p<0 (p<0, p< (p<0 (p< (p

Abstract Background: Chronic Chagas cardiomyopathy (CCC) is caused by an inflammatory process induced by Trypanosoma cruzi, which leads to myocarditis with reactive and reparative fibrosis. CCC progresses with myocardial perfusion abnormalities and histopathological events that affect cardiorespiratory fitness (CRF). Objectives: We evaluated the effects of aerobic physical training (APT) on myocardial perfusion and on morphological and functional impairments related with inflammation and fibrosis in Syrian hamsters with CCC. As a secondary objective, we analyzed the cross-sectional areas of the skeletal muscle. Methods: Hamsters with CCC and their respective controls were divided into four groups: CCC sedentary, CCC-APT, sedentary control and APT control. Seven months after infection, the animals underwent echocardiography, myocardial perfusion scintigraphy and cardiopulmonary exercise testing. Moderate-intensity APT was performed for fifty minutes, five times a week, for eight weeks. Subsequently, the animals were reassessed. Histopathological analysis was conducted after the above-mentioned procedures. The level of significance was set at 5% in all analyses (p<0.05). Results: CCC sedentary animals presented worse myocardial perfusion defects (MPD) over time, reduced left ventricle ejection fraction (LVEF) and showed more inflammation and fibrosis when compared to other groups (mixed ANOVA analysis). Conversely, APT was able to mitigate the progression of MPD, ameliorate inflammation and fibrosis and improve CRF efficiency in CCC-APT animals. Conclusions: Our study demonstrated that APT ameliorated cardiac dysfunction, MPD, and reduced inflammation and fibrosis in CCC hamster models. Additionally, CCC-SED animals presented skeletal muscle atrophy while CCC-APT animals showed preserved skeletal muscle CSA. Understanding APT's effects on CCC's pathophysiological dimensions is crucial for future research and therapeutic interventions. Background (CCC cruzi CRF. . (CRF) Objectives (APT objective crosssectional cross sectional Methods CCCAPT, CCCAPT APT, infection echocardiography testing Moderateintensity Moderate intensity minutes week weeks Subsequently reassessed abovementioned above mentioned procedures 5 p<0.05. p005 p p<0.05 0 05 (p<0.05) Results MPD (MPD time LVEF (LVEF mixed analysis. analysis) Conversely Conclusions dysfunction models Additionally CCCSED SED CSA APTs s CCCs interventions (CRF p00 p<0.0 (p<0.05 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

ABSTRACT Introduction: The superiority of the functional results of robot-assisted radical prostatectomyis still controversial. Despite this, it is known that minimally invasive surgery obtains better results when analyzing blood loss, blood transfusion and length of stay, for example. Several studies have analyzed the impact of the resident physician's involvement on the results of urological surgeries. The simple learning curve for robot-assisted radical prostate surgery is estimated to be around 10 to 12 cases. Learning curve data for robotic surgeons is heterogeneous, making it difficult to analyze. Rare studies compare the results of a radical prostatectomy of an inexperienced surgeon starting his training in open surgery, with the results of the same surgeon, a few years later, starting training in robotic surgery. Objective: to analyze the results of open radical prostatectomy surgeries (ORP) performed by urology residents, comparing them to the results of robot-assisted radical prostatectomy (RARP), performed by these same surgeons, after completing their training in urology. Materials and methods: a retrospective analysis of the cases of only 3 surgeons was performed. 50 patients underwent ORP (group A). The surgeons who operated on the ORP patients were in the 3rd and final year of the urology residency program and beginners in ORP surgery, but with at least 4 years of experience in open surgery. The same surgeons, already trained urologists, began their training in robotic surgery and performed 56 RARP surgeries (group B). For the comparative analysis, data were collected on age, number of lymph nodes removed, surgery time, hospitalization time, drain volume, drain permanence time, indwelling bladdercateter (IBC) permanence time, positive surgical margin, biochemical recurrence, risk classification (ISUP), intra and postoperative complications, urinary incontinence (UI) and erectile dysfunction (ED). The console used was the Da Vinci Si, from Intuitive®. For statistical analysis, the Shapiro-Wilk test verified that the data did not follow normality, the Levene test guaranteed homogeneity, and the Mann-Whitney test performed the comparative analysis of the quantitative data. For the analysis of qualitative data, the Chi-square test was used for nominal variables and the Mann-Whitney U test for ordinal variables. Additionally, the Friedman test analyzed whether there was an improvement in the perception of UI or ED over the months, for each group individually (without comparing them), and the post-hoc Durbin-Conover test, for the results with statistically significant difference. We used a p-value < 0.05, and the Jamovi® program (Version 2.0). Results: there was no statistically significant difference between the groups for age, number of lymph nodes removed, positive surgical margin, biochemical recurrence, risk classification and urinary incontinence. Additionally, we observed that the surgical time was longer in group B. On the other hand, the length of stay, drain volume, drain time, IBC time, complication rate and levels of erectile dysfunction in the third and sixth months were higher in group A, when compared to group B. We also observed that there was no evolutionary improvement in ED over the months in both groups, and that there was a perception of improvement in UI from the 1st to the 3rd month in group A, and from the 1st to the 6th month, and from the 3rd to the 12th month, in group B. Conclusion: the learning curve of RARP is equivalent to the curve of ORP. In general, the results for the robotic group were better, however, the functional results were similar between the groups, with a slight tendency of advantage for the robotic arm. Introduction robotassisted robot assisted controversial this loss stay example physicians physician s 1 heterogeneous later Objective (ORP residents RARP, , (RARP) methods 5 A. A . A) rd urologists B B) age removed volume (IBC margin recurrence ISUP, ISUP (ISUP) complications (UI ED. (ED) Si Intuitive Intuitive® ShapiroWilk Shapiro Wilk normality homogeneity MannWhitney Mann Whitney Chisquare Chi square Additionally without them, them) posthoc post hoc DurbinConover Durbin Conover pvalue p value 005 0 05 0.05 Jamovi Version 2.0. 20 2.0 2 2.0) Results hand st th Conclusion general however arm (RARP (ISUP (ED 00 0.0 2. 0.

Resumen El compuesto plástico-madera es un material que combina sustancias distintas, como polímeros y polvo de madera, manteniendo sus identidades incluso después del procesamiento. Estos compuestos se utilizan ampliamente en aplicaciones como muebles, construcción y balcones debido a su durabilidad, resistencia y sostenibilidad. Este artículo bibliométrico tiene como objetivo analizar la producción científica sobre compuestos plástico-madera, identificando tendencias y avances. Utilizando la plataforma Scopus como base de datos, se seleccionaron 835 artículos publicados entre 2010 y 2022. China y Estados Unidos son los países más destacados en la investigación de estos compuestos. Los polímeros termoplásticos como polietileno, polipropileno y cloruro de polivinilo se utilizan ampliamente, al igual que las fibras de madera de especies como pino y eucalipto. Las técnicas de producción más comunes son la extrusión y la moldeo por inyección, mientras que los análisis mecánicos, la microscopía electrónica de barrido, la espectroscopía infrarroja, el análisis termogravimétrico y la calorimetría diferencial de barrido son las técnicas de caracterización más frecuentes. Estos compuestos plástico-madera han sido una opción sostenible y versátil, impulsando la innovación en la industria. Este análisis bibliométrico proporciona información relevante para el desarrollo futuro de materiales y procesos en esta área.

Resumo O compósito plástico-madeira é um material que combina substâncias distintas, como polímeros e pó de madeira, mantendo suas identidades mesmo após o processamento. Esses compósitos são amplamente utilizados em aplicações como móveis, construção civil e varandas devido à sua durabilidade, resistência e sustentabilidade. Este artigo bibliométrico tem como objetivo analisar a produção científica sobre compósitos plástico-madeira, identificando tendências e avanços. Utilizando a plataforma Scopus como base de dados, foram selecionados 835 artigos publicados entre 2010 e 2022. A China e os Estados Unidos são os países mais proeminentes na pesquisa desses compósitos. Polímeros termoplásticos, como polietileno, polipropileno e policloreto de vinila, são amplamente utilizados, assim como fibras de madeira provenientes de espécies como pinus e eucalipto. As técnicas de produção mais comuns são a extrusão e a moldagem por injeção, enquanto as análises mecânicas, microscopia eletrônica de varredura, espectroscopia de infravermelho, análise termogravimétrica e calorimetria diferencial de varredura são as técnicas de caracterização mais frequentes. Esses compósitos plástico-madeira têm sido uma escolha sustentável e versátil, impulsionando a inovação na indústria. Esta análise bibliométrica fornece informações relevantes para o desenvolvimento futuro de materiais e processos nessa área.

Abstract Composite plastic-wood is a material that combines distinct substances, such as polymers and wood powder, maintaining their identities even after processing. These composites are widely used in applications such as furniture, construction, and balconies due to their durability, strength, and sustainability. This bibliometric article aims to analyze scientific production on plastic-wood composites, identifying trends and advancements. Using the Scopus platform as a database, 835 articles published between 2010 and 2022 were selected. China and the United States are the most prominent countries in researching these composites. Thermoplastic polymers like polyethylene, polypropylene, and polyvinyl chloride are widely used, as are wood fibers from species such as pine and eucalyptus. The most common production techniques are extrusion and injection molding, while mechanical analysis, scanning electron microscopy, infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry are the most frequent characterization techniques. These plastic-wood composites have been a sustainable and versatile choice, driving innovation in the industry. This bibliometric analysis provides relevant information for the future development of materials and processes in this field.

ABSTRACT Species of the genus Capsicum, especially peppers, are economically important and widely consumed worldwide. The application of animal waste as organic fertilizer is a simple and cost-effective technique for applying nutrients to the soil. Combining cattle manure with humic substances can stimulate plant metabolism, resulting in increased nutrient absorption and assimilation. Therefore, the objective in this study was to evaluate doses of cattle manure combined with humic substances for stimulating plant metabolism and morphophysiological and nutritional processes in pepper plants. A randomized block design with four replicates was used, in a 4×3 factorial arrangement consisting of four cattle manure doses (8, 18, 28, and 38 Mg ha-1) and three humic substance doses (0, 8, and 12 kg ha-1). Humic substances (12 kg ha-1) enhanced gas exchange, increasing net photosynthesis (34.2%), stomatal conductance (12.7%), instantaneous water use efficiency (15.87%), instantaneous carboxylation efficiency (37.37%), and absorbed energy conversion efficiency (23.53%). Cattle manure adequately met the crop’s nutritional requirements, while humic substances increased the number and thickness of plant root hairs. The most effective combination to increase photosynthetic activity in pepper plants was 38 Mg ha-1 of cattle manure combined with 8 kg ha-1 of humic substances. Humic substances stimulated positive morphophysiological responses in organic pepper crops, which resulted in increased production. Capsicum peppers worldwide costeffective cost soil assimilation Therefore used 43 4 3 4× (8 18 28 ha1 ha 1 0, 0 (0 ha1. . (1 exchange 34.2%, 342 34.2% , 34 2 (34.2%) 12.7%, 127 12.7% 7 (12.7%) 15.87%, 1587 15.87% 15 87 (15.87%) 37.37%, 3737 37.37% 37 (37.37%) 23.53%. 2353 23.53% 23 53 (23.53%) crops crop s requirements hairs ha- production ( 34.2 (34.2% 12.7 (12.7% 158 15.87 (15.87% 373 37.37 (37.37% 235 23.53 5 (23.53% 34. (34.2 12. (12.7 15.8 (15.87 37.3 (37.37 23.5 (23.53 (34. (12. 15. (15.8 37. (37.3 23. (23.5 (34 (15. (37. (23. (3 (15 (37 (23 (2

RESUMO As espécies do gênero Capsicum, principalmente pimentão, possuem grande relevância econômica e são amplamente consumidas em todo o mundo. A aplicação de dejetos animais como fertilizante orgânico é uma técnica simples e barata de distribuição de nutrientes ao solo. O esterco bovino em associação com substâncias húmicas pode estimular o metabolismo das plantas, resultando no aumento da absorção e assimilação de nutrientes. Portanto, o objetivo neste estudo foi avaliar doses de esterco bovino associado a substâncias húmicas para estimular o metabolismo vegetal, a morfofisiologia e a nutrição em pimentões. O delineamento utilizado foi em blocos casualizados, distribuídos em arranjo fatorial 4 x 3, referente a quatro doses de esterco bovino (8, 18, 28 e 38 t ha-1) e três doses de substâncias húmicas (0, 8 e 12 kg ha-1), com quatro repetições. Substâncias húmicas (12 kg ha-1) estimularam as trocas gasosas, aumentando a fotossíntese líquida (34,2%), a condutância estomática (12,7%), a eficiência instantânea do uso da água (15,87%), a eficiência instantânea de carboxilação (37,37%) e a eficiência efetiva da absorção conversão de energia (23,53%). O esterco bovino supriu adequadamente as necessidades nutricionais da cultura, enquanto as substâncias húmicas aumentaram o número e a espessura dos pelos radiculares do pimentão. A combinação de manejo mais eficaz para aumentar a atividade fotossintética em pimentões é 38 t ha-1 de esterco combinado com 8 kg ha-1 de substâncias húmicas. As substâncias húmicas estimularam respostas morfofisiológicas positivas no cultivo de pimentão orgânico, o que resultou no aumento da produção. Capsicum mundo solo plantas Portanto vegetal casualizados 3 8, (8 18 2 ha1 ha 1 0, 0 (0 ha1, , repetições (1 gasosas 34,2%, 342 34,2% 34 (34,2%) 12,7%, 127 12,7% 7 (12,7%) 15,87%, 1587 15,87% 15 87 (15,87%) 37,37% 3737 37 (37,37% 23,53%. 2353 23,53% . 23 53 (23,53%) cultura ha- produção ( 34,2 (34,2% 12,7 (12,7% 158 15,87 (15,87% 37,37 373 (37,37 235 23,53 5 (23,53% 34, (34,2 12, (12,7 15,8 (15,87 37,3 (37,3 23,5 (23,53 (34, (12, 15, (15,8 37, (37, 23, (23,5 (34 (15, (37 (23, (3 (15 (23 (2

Abstract Objective Malnutrition is characterized by situations of undernutrition and obesity resulting from the lack of micronutrients with the greatest impact on children. The objective of this review was to highlight inadequate food consumption, food security, and nutritional inadequacy leading to hidden hunger and the prevention and treatment of the main micronutrient deficiencies in Brazil. Data source Literature review carried out through a bibliographic survey in PubMed (National Library of Medicine, United States), Lilacs (Latin American and Caribbean Literature in Health Sciences), and SciELO (Scientific Electronic Library Online) databases. The search used the terms Occult hunger, (hidden hunger), and Child, in articles published between 2013 and 2023 in Portuguese, English and Spanish. The search was performed on 06/25/2023. Data synthesis The lack of micronutrients can occur insidiously and without clinical manifestations, being called hidden hunger. The prevention of nutritional deficiencies is part of the recommended actions in childcare, with healthy eating. Studies were cited related to macro and micronutrient intake deficiencies, both national and international, and strategies to improve micronutrient intake, including routine supplementation of iron, and vitamins D and A. The diagnosis, prevention, and treatment of the main deficiencies in Brazil (iron, vitamin A, vitamin D, zinc), currently adopted, concluded the topic. Conclusion Zero hunger and zero obesity must be part of the same policy, together with a nutritional education program. children consumption security National Medicine States, States , States) Latin Sciences, Sciences Sciences) Scientific Online databases hunger) Child 201 202 Portuguese Spanish 06252023 06 25 06/25/2023 manifestations childcare eating international iron A diagnosis (iron zinc, zinc zinc) adopted topic policy program 20 0625202 0 2 06/25/202 062520 06/25/20 06252 06/25/2 0625 06/25/ 062 06/25 06/2 06/

ABSTRACT Copper is an essential element for beet; however, it needs to be made available in adequate quantities since this nutrient, which is a heavy metal, can cause toxicity to plants and/or humans. This study aimed to evaluate the agronomic performance of beet fertigated with copper in a semi-arid region of Brazil. Two experiments were carried out in complete randomized blocks, with five treatments (0, 1.5, 3.0, 4.0, and 6.0 kg ha-1 of copper) and four replicates. In 2019, the copper content was within the adequate range for beet. In 2021, fertigation with copper above 0.8 kg ha-1 led to contents in the phytotoxicity range, which may explain the reduction in total and tuberous root dry mass accumulation. Fertilization with copper increased marketable yield in 2019 (17.32 t ha-1 at the dose of 3.9 kg ha-1 of copper), while, in 2021, there was no fit of the equations. Copper fertilization altered the tuberous root pH but did not influence the other tuberous root quality components. Plants fertilized with copper accumulated more copper in the leaves than in the tuberous root, with a maximum accumulation of 6.0 kg ha-1 of copper in 2019 and 2021. Fertilization with 3.9 kg ha-1 suits soils with low copper content. however nutrient metal andor or humans semiarid semi arid Brazil blocks 0, 0 (0 15 1 5 1.5 30 3 3.0 40 4 4.0 60 6 6. ha1 ha ha- replicates 2021 08 8 0. 201 17.32 1732 17 32 (17.3 39 9 3. copper, , while equations components ( 1. 4. 202 20 17.3 173 (17. 2 17. (17 (1

RESUMO O cobre é um elemento essencial à beterraba, no entanto, é necessário disponibilizá-lo em quantidade adequada uma vez que esse nutriente, que é um metal pesado, pode causar toxicidade às plantas e, ou, ao ser humano. Esta pesquisa teve como objetivo avaliar o desempenho agronômico de beterraba fertirrigada com cobre em uma região semiárida do Brasil. Foram conduzidos dois experimentos em delineados em blocos casualizados ao acaso, com cinco tratamentos (0, 1.5, 3.0, 4.5 e 6.0 kg ha-1 de cobre) e quatro repetições. Em 2019, o teor de cobre estava dentro da faixa adequada para a beterraba. Em 2021, a fertirrigação com cobre acima de 0.8 kg ha-1 proporcionou teores na faixa de fitotoxicidade, o que pode explicar a redução no acúmulo de massa seca total e de raízes tuberosas. A adubação com cobre aumentou a produtividade comercial em 2019 (17.32 t ha-1 na dose de 3.9 kg ha-1 de cobre) enquanto que, em 2021, não houve modelo ajustado. A adubação alterou o pH da raiz tuberosa, mas não influenciou nos demais atributos de qualidade pós-colheita da raiz tuberosa. Plantas adubadas com cobre acumularam mais cobre nas folhas do que na raiz tuberosa, com máxima acumulada em 2019 e em 2021, na dose 6.0 kg ha-1 de cobre. A adubação com 3.9 kg ha-1 é adequada para solos com baixo teor de cobre. entanto disponibilizálo disponibilizá lo nutriente pesado ou humano Brasil acaso 0, 0 (0 15 1 5 1.5 30 3 3.0 45 4 4. 60 6 6. ha1 ha ha- repetições 2021 08 8 0. fitotoxicidade tuberosas 201 17.32 1732 17 32 (17.3 39 9 3. ajustado tuberosa póscolheita pós colheita ( 1. 202 20 17.3 173 (17. 2 17. (17 (1

Abstract The aim was to associate living, health and oral health conditions with the quality of life (QL) of children and adolescents (CA) with sickle cell disease (SCD). Of the 120 eligible users of a public hematological service, 106 CA with SCD from 6 to 18 years of age, and their caregivers, answered semi-structured questions about socio-demographic, health and oral health conditions. For QL, we used the validated instrument PedsQLSCD™. The oral clinical examination occurred according to the guidelines of WHO and SB Brazil 2010. The majority of CA were non-white people (88%), mean age of 10.4 (±2.9) years, family income of up to two monthly minimum wages, for 03 to 05 members, with diagnosis of sickle cell anemia by neonatal screening, hospitalizations were due allergic crises, polypharmacy and dental caries (51%) were present. “About the Impact of My Pain” was the best-fit model for the QLSCD (adjusted R²=56%; AIC=28.67; p=0.04). Dental caries in permanent dentition worsened the QLSCD (OR=0.53; IC95%=0.35-0.78; p<0.05) and was associated with the type of school, car ownership, number of family members, of complications and of the medications. To overcome this scenario, programmatic actions are required, and implementation of public policies specifically directed towards these groups. living QL (QL (CA SCD. . (SCD) 12 service 10 1 caregivers semistructured semi structured sociodemographic, sociodemographic socio demographic, demographic socio-demographic PedsQLSCD PedsQLSCD™ 2010 nonwhite non white 88%, 88 88% , (88%) 104 4 10. ±2.9 29 2 9 (±2.9 wages 0 members screening crises 51% 51 (51% present About Pain bestfit best fit adjusted R²=56% R²56 R R² 56 AIC=28.67 AIC2867 AIC 28 67 p=0.04. p004 p p=0.04 04 p=0.04) OR=0.53 OR053 OR 53 (OR=0.53 IC95%=0.350.78 IC95035078 IC IC95%=0.35 0.78 IC95 35 78 IC95%=0.35-0.78 p<0.05 p005 school ownership medications scenario required groups (SCD 201 8 (88% ±2. (±2. 5 (51 R²=56 R²5 AIC=28.6 AIC286 p00 p=0.0 OR=0.5 OR05 (OR=0.5 350 IC95%=0.350.7 IC9503507 IC95035 IC95%=0.3 078 0.7 IC9 3 7 IC95%=0.35-0.7 p<0.0 20 (88 ±2 (±2 (5 R²=5 AIC=28. AIC28 p0 p=0. OR=0. OR0 (OR=0. IC95%=0.350. IC950350 IC9503 IC95%=0. 07 0. IC95%=0.35-0. p<0. (8 ± (± ( R²= AIC=28 AIC2 p=0 OR=0 (OR=0 IC95%=0.350 IC950 IC95%=0 IC95%=0.35-0 p<0 AIC=2 p= OR= (OR= IC95%= IC95%=0.35- p< AIC= (OR IC95%

Resumo Objetivou-se associar condições de vida, de saúde e de saúde bucal à qualidade de vida (QLV) de crianças e adolescentes (CA) com Doença Falciforme (DF). Dos 120 usuários elegíveis de um serviço público hematológico, 106 CA entre 6 e 18 anos de idade, e seus cuidadores, responderam questões semiestruturadas sobre condições sociodemográficas, de saúde e saúde bucal. Para a QLV, o instrumento validado PedsQL DF® foi aplicado. Na sequência, realizou-se o exame clínico bucal nas CA segundo diretrizes da OMS e do SB Brasil 2010. A maioria das CA era negra (88%), idade média de 10,4 (±2.9) anos, renda familiar de até dois salários mínimos, para 03 a 05 membros, diagnosticadas na triagem neonatal com anemia falciforme, internadas por crises álgicas, em uso de polifarmácia e com cárie dental (51%). O domínio “Sobre o Impacto da Minha Dor” foi preditivo da QLVDF (R² ajustado =56%; AIC=28.67; p=0,04). Nele, a cárie dental na dentição permanente piorou a QLVDF das CA (OR=0.53; IC95%=0.35-0.78; p<0,05), associando-se ao tipo de escola, posse de carro e do número de membros na família, de complicações da DF e de medicamentos. Os achados ratificam a dor como marca da DF e mostram a importância da saúde bucal na QLDF das CA. A implementação de políticas públicas específicas pode superar esse cenário. Objetivouse Objetivou se QLV (QLV (CA DF. . (DF) 12 hematológico 10 1 cuidadores sociodemográficas aplicado sequência realizouse realizou 2010 88%, 88 88% , (88%) 104 4 10, ±2.9 29 2 9 (±2.9 mínimos 0 falciforme álgicas 51%. 51 51% (51%) Sobre Dor R² R (R =56% 56 AIC=28.67 AIC2867 AIC 28 67 p=0,04. p004 p p=0,04 04 p=0,04) Nele OR=0.53 OR053 OR 53 (OR=0.53 IC95%=0.350.78 IC95035078 IC IC95%=0.35 0.78 IC95 35 78 IC95%=0.35-0.78 p<0,05, p005 p<0,05 p<0,05) associandose associando escola família medicamentos cenário (DF 201 8 (88% ±2. (±2. 5 (51% =56 AIC=28.6 AIC286 p00 p=0,0 OR=0.5 OR05 (OR=0.5 350 IC95%=0.350.7 IC9503507 IC95035 IC95%=0.3 078 0.7 IC9 3 7 IC95%=0.35-0.7 p<0,0 20 (88 ±2 (±2 (51 =5 AIC=28. AIC28 p0 p=0, OR=0. OR0 (OR=0. IC95%=0.350. IC950350 IC9503 IC95%=0. 07 0. IC95%=0.35-0. p<0, (8 ± (± (5 = AIC=28 AIC2 p=0 OR=0 (OR=0 IC95%=0.350 IC950 IC95%=0 IC95%=0.35-0 p<0 ( AIC=2 p= OR= (OR= IC95%= IC95%=0.35- p< AIC= (OR IC95%

Abstract The present study sought to evaluate the antimicrobial and anti-adherent potential of Eucalyptus radiata essential oil against food-borne strains of Escherichia coli. The study was performed using the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). In addition, the disk diffusion technique was used to evaluate the association of Eucalyptus radiata essential oil with synthetic antimicrobials. The Minimum Inhibitory Adherence Concentration (MIC) was also performed. The results revealed that E. radiata showed antimicrobial activity against the E. coli strains tested, with MIC values ranging from 500 μg/mL to 1000 μg/mL and MBC values ranging from 500 μg/mL to 1,024 μg/mL. As for the associations, it was observed that E. radiata oil exhibited a synergistic effect for some antibiotics, especially Ceftriaxone, with greater interference from the essential oil. Furthermore, it was effective in inhibiting the adherence of bacterial strains of E. coli, showing a more significant antibiofilm effect than the antibacterial agent 0.12% chlorhexidine digluconate. In summary, the essential oil of E. radiata showed antimicrobial potential against strains of E. coli of food origin, and can therefore, through in-depth studies, be used alone or in association with synthetic antimicrobials to combat infections caused by this pathogen. antiadherent anti adherent foodborne borne (MIC MBC. . (MBC) addition E tested 50 μgmL μg mL 100 1024 1 024 1,02 associations antibiotics Ceftriaxone Furthermore 012 0 12 0.12 digluconate summary origin therefore indepth depth studies pathogen (MBC 5 10 102 02 1,0 01 0.1 1, 0.

Resumo O presente estudo buscou avaliar o potencial antimicrobiano e antiaderente do óleo essencial de Eucalipto radiata frente às cepas de veiculação alimentar de Escherichia coli. O estudo foi realizado usando a Concentração Inibitória Mínima (CIM) e Concentração Bactericida Mínima (CBM). Além disso, a técnica de difusão em disco foi usada para avaliar a associação do óleo essencial de Eucalipto radiata com antimicrobianos sintéticos. A Concentração Inibitória Mínima de Aderência (CIMA) também foi realizada. Os resultados revelaram que E. radiata apresentou atividade antimicrobiana contra as cepas de E. coli testadas, com valores de CIM variando entre 500 μg/mL a 1000 μg/mL e valores de CBM variando entre 500 μg/mL a 1,024 μg/mL. Quanto às associações, observou-se que o óleo de E. radiata exibiu efeito sinérgico para alguns antibióticos, sobretudo a Ceftriaxona, apresentando maior interferência do óleo essencial. Além disso, foi eficaz na inibição a aderência das cepas bacterianas de E. coli, mostrando um efeito antibiofilme mais significativo que o agente antibacteriano digluconato de clorexidina a 0.12%. Em resumo, o óleo essencial de E. radiata apresentou potencial antimicrobiano contra cepas de E. coli de origem alimentar, podendo assim, mediante estudos aprofundados, ser utilizado isoladamente ou em associação com antimicrobianos sintéticos para combater infecções causadas por esse patógeno. (CIM CBM. . (CBM) disso CIMA (CIMA realizada E testadas 50 μgmL μg mL 100 1024 1 024 1,02 associações observouse observou se antibióticos Ceftriaxona 012 0 12 0.12% resumo assim aprofundados patógeno (CBM 5 10 102 02 1,0 01 0.12 1, 0.1 0.

ABSTRACT Managing electrical conductivity levels is one of the fundamentals required to obtain greater production and better quality of vegetables. The aim of this study was to evaluate the effect of electrical conductivity of the nutrient solution on the kohlrabi crop cultivated in semi-hydroponic system. A randomized block design was used with five treatments associated with the electrical conductivity of the nutrient solution (1.31, 1.71, 2.37, 2.98, and 3.75 dS m-1) and four replications. The plants were harvested 78 days after transplanting and evaluated for growth, production, and postharvest quality. Nutrient solution with electrical conductivity (EC) of 1.31 dS m-1 promotes greater production of purple kohlrabi. The increase in EC reduced linearly most of the analyzed variables (leaf area, fresh mass of leaves, bulb and shoot, dry mass of leaves and total, bulb volume and firmness), with more significant losses for the bulb fresh mass (50.54%) and bulb volume (57.37%) variables. The use of nutrient solution with EC between 2.3 and 2.9 dS m-1 increased the vitamin C content and the titratable acidity. vegetables semihydroponic semi hydroponic system 1.31, 131 1 31 (1.31 171 71 1.71 237 2 37 2.37 298 98 2.98 375 3 75 3.7 m1 m replications 7 growth (EC 1.3 m- leaf area shoot total firmness, firmness , firmness) 50.54% 5054 50 54 (50.54% 57.37% 5737 57 (57.37% 23 2. 29 9 acidity 13 (1.3 17 1.7 3. 1. 50.54 505 5 (50.54 57.37 573 (57.37 (1. 50.5 (50.5 57.3 (57.3 (1 50. (50. 57. (57. ( (50 (57 (5

RESUMO O manejo dos níveis de condutividade elétrica é um dos fundamentos necessários para se obter maior produção e melhor qualidade de hortaliças. O objetivo deste trabalho foi avaliar o efeito da condutividade elétrica da solução nutritiva na cultura da couve-rábano cultivada em sistema semi-hidropônico. O delineamento experimental foi em blocos casualizados com cinco tratamentos associados à condutividade elétrica da solução nutritiva (1,31; 1,71; 2,37; 2,98 e 3,75 dS m-1) e quatro repetições. As plantas foram colhidas 78 dias após o transplante e avaliadas quanto ao crescimento, produção e qualidade pós-colheita. Solução nutritiva com condutividade elétrica (CE) de 1,31 dS m-1 proporciona maior produção de couve-rábano roxa. O aumento da CE reduziu linearmente a maioria das variáveis analisadas (área foliar, massa fresca de folhas, bulbos e parte aérea, massa seca de folhas e totais, volume e firmeza de bulbos), com perdas mais expressivas para as variáveis massa fresca de bulbos (50,54%) e volume de bulbos (57,37%). A utilização de solução nutritiva com CE entre 2,3 e 2,9 dS m-1 aumentou o teor de vitamina C e a acidez titulável. hortaliças couverábano couve rábano semihidropônico. semihidropônico semi hidropônico. hidropônico semi-hidropônico 131 1 31 (1,31 1,71 171 71 2,37 237 2 37 298 98 375 3 75 3,7 m1 m repetições 7 crescimento póscolheita. póscolheita pós colheita. colheita pós-colheita (CE 1,3 m- roxa área foliar aérea totais bulbos, , bulbos) 50,54% 5054 50 54 (50,54% 57,37%. 5737 57,37% . 57 (57,37%) 23 2, 29 9 titulável 13 (1,3 1,7 17 3, 1, 50,54 505 5 (50,54 573 57,37 (57,37% (1, 50,5 (50,5 57,3 (57,37 (1 50, (50, 57, (57,3 ( (50 (57, (5 (57