We report a facile hydrothermal method for the synthesis of niobium pentoxide (Nb2O5) under two different temperatures, 120 °C (Nb2O5-120) and 150 °C (Nb2O5-150). The obtained materials were characterized by structural, optical and morphological techniques. Also, the photocatalytic properties of the Nb2O5 samples were evaluated in two reactions under ultraviolet (UVC) irradiation: degradation of methylene blue (MB) and indigo carmine (IC) dyes; and esterification of free fatty acids (FFA) present in waste cooking oil (WCO). The Nb2O5 was formed at different temperatures of synthesis, and the increase in temperature did not cause significant changes in the structural and optical characteristics, but resulted in an increased surface area of the synthesized materials. Both synthesized materials showed excellent efficiency for dye photodegradation. The sample Nb2O5-150 presented the best performance for the MB photodegradation, with almost 85% of the removal efficiency. In this case, the adsorption of MB molecules on the surface of the material was high due to the favorable electrostatic interaction and also because of its high surface area. For the IC photodegradation, the adsorption was insignificant, and both samples presented approximately 100% of the removal efficiency. These materials were also promising for the reduction of free fat acids in waste oil by photoesterification. NbO Nb O (Nb2O5 12 C Nb2O5120 (Nb2O5-120 15 Nb2O5150. Nb2O5150 . (Nb2O5-150) techniques Also Nb2O UVC (UVC irradiation (MB (IC dyes FFA (FFA WCO. WCO (WCO) characteristics photodegradation Nb2O5-15 85 case insignificant 100 photoesterification (Nb2O 1 Nb2O512 (Nb2O5-12 Nb2O515 (Nb2O5-150 (WCO Nb2O5-1 8 10 Nb2O51 (Nb2O5-1 (Nb2O5-15 Nb2O5- (Nb2O5-

ABSTRACT Alternative techniques for cultivation without soil are widespread; however, studies comparing hydroponic systems still need to be studied, mainly in semi-arid regions. The present study aimed to evaluate the effect of hydroponic systems on the yield and quality of lettuce cultivars subjected to different electrical conductivities of the nutrient solution. The research was conducted in a greenhouse, adopting a completely randomized design in a 2 × 2 × 3 factorial scheme, being two lettuce cultivars (Cinderela and Rubinela), two electrical conductivities (2.90 and 1.6 dS m-1), and three hydroponics systems (NFT, semi-hydroponic, and floating), with three replications. The number of leaves, leaf succulence, specific leaf area, leaf fresh mass, total dry mass, leaf area, titratable acidity, vitamin C, and soluble solids were evaluated. Cinderela cultivar showed the highest average leaf fresh mass, total dry mass, leaf area, and vitamin C values. The NFT and floating systems provided the highest leaf yield and quality, especially in the solution of 1.60 dS m-1. The semi-hydroponic system provided greater development of the plants with a more concentrated nutrient solution (2.90 dS m-1). widespread however studied semiarid semi arid regions greenhouse scheme Rubinela, Rubinela , Rubinela) 2.90 290 90 (2.9 16 1 6 1. m1, m1 m m-1) NFT, (NFT semihydroponic, semihydroponic hydroponic, floating, floating) replications leaves succulence area mass acidity evaluated values 160 60 m1. m-1 . 2.9 29 9 (2. m- 2. (2 (

RESUMO Técnicas alternativas de cultivo sem solo são difundidas; no entanto, estudos comparando os sistemas hidropônicos ainda precisam ser estudados, principalmente em regiões semiáridas. O presente estudo teve como objetivo avaliar a efeito de sistemas hidropônicos na produtividade e qualidade de cultivares de alface submetidas a diferentes condutividades elétricas da solução nutritiva. A pesquisa foi conduzida em casa de vegetação, adotando delineamento inteiramente casualizado. em esquema fatorial 2 × 2 × 3, sendo duas cultivares de alface (Cinderela e Rubinela), duas condutividades elétricas (2,90 e 1,6 dS m-1), e três sistemas hidropônicos (NFT, semi-hidropônico e floating), com três repetições. Foram avaliados número de folhas, suculência foliar, área foliar específica, massa fresca foliar, massa seca total, área foliar, acidez titulável, vitamina C e sólidos solúveis. A cultivar Cinderela apresentou maior massa fresca de folhas, massa seca total, área foliar, acidez titulável e vitamina C e sólidos solúveis. Os sistemas NFT e floating proporcionaram maior produtividade e qualidade foliar, especialmente na solução de 1,60 dS m-1. O sistema semi-hidropônico proporcionou maior desenvolvimento das plantas com solução nutritiva mais concentrada (2,90 dS m-1). difundidas entanto estudados semiáridas vegetação casualizado 3 Rubinela, Rubinela , Rubinela) 2,90 290 90 (2,9 16 1 6 1, m1, m1 m m-1) NFT, (NFT semihidropônico semi hidropônico floating, floating) repetições folhas específica total solúveis 160 60 m1. 1. m-1 . 2,9 29 9 (2, m- 2, (2 (

RESUMEN Objetivo construir y validar el contenido de un instrumento de evaluación socioestructural y conductual asociada a la infección por VIH en jóvenes. Método estudio metodológico, desarrollado en dos etapas: elaboración del instrumento; y validación de contenido. Los ítems que conformaron el instrumento fueron seleccionados a través de una revisión literaria, tomando como referencia los dominios multinivel del Modelo Ecológico Social Modificado, categorizados en componentes socioestructurales y conductuales. El contenido fue evaluado por expertos en dos rondas realizadas mediante la técnica Delphi, suponiendo una tasa de acuerdo de al menos el 80%. Resultados la primera versión del instrumento contuvo 52 ítems, distribuidos en tres dominios. En la primera ronda, 19 ítems (36,5%) tuvieron un Índice de Validez de Contenido inferior a 0,80, dos ítems fueron excluidos y el resto fueron reformulados. En la segunda ronda, se excluyeron 2 ítems y se incorporaron 3 como subítems, totalizando 45 ítems. El Índice de Validez de Contenido del Instrumento fue del 95%. Conclusión e implicaciones para la práctica las recomendaciones de los expertos contribuyeron para la calificación del instrumento Evaluación Socioestructural y del Comportamiento-VIH, permitiendo la reorganización del contenido. El instrumento es válido para identificar factores socioestructurales y conductuales asociados a la infección por VIH en jóvenes, con potencial para constituir una planificación de atención preventiva. jóvenes metodológico etapas literaria Modificado Delphi 80 80% 5 ronda 1 36,5% 365 36 (36,5% 080 0 0,80 reformulados subítems 4 95 95% ComportamientoVIH, ComportamientoVIH Comportamiento VIH, Comportamiento-VIH preventiva 8 36,5 (36,5 08 0,8 9 36, (36, 0, (36 (3 (

ABSTRACT Objective to construct and validate the content of an instrument for sociostructural and behavioral assessment associated with HIV infection in young people. Method a methodological study developed in two steps: instrument elaboration; and content validity. The items that made up the instrument were selected through a literary review using the Modified Social Ecological Model multilevel domains as a reference, categorized into sociostructural and behavioral components. Content was assessed by experts in two rounds conducted using the Delphi technique, assuming an agreement rate of at least 80%. Results the first version of the instrument contained 52 items, distributed across three domains. In the first round, 19 items (36.5%) had a Content Validity Index lower than 0.80, two items were excluded and the rest were reformulated. In the second round, 2 items were excluded and 3 were incorporated as subitems, totaling 45 items. The Instrument Content Validity Index was 95%. Conclusion and implications for practice experts’ recommendations contributed qualifying the Sociostructural and Behavioral Assessment-HIV instrument, enabling content reorganization. The instrument is valid for identifying socio-structural and behavioral factors associated with HIV infection in young people, with the potential to constitute preventive care planning. people steps elaboration validity reference components technique 80 80% 5 round 1 36.5% 365 36 (36.5% 080 0 0.80 reformulated subitems 4 95 95% AssessmentHIV Assessment reorganization socio structural planning 8 36.5 (36.5 08 0.8 9 36. (36. 0. (36 (3 (

RESUMO Objetivo construir e validar conteúdo de instrumento para avaliação socioestrutural e comportamental associado à infecção pelo HIV em jovens. Método estudo metodológico, desenvolvido em duas etapas: elaboração do instrumento; e validação de conteúdo. Os itens que compuseram o instrumento foram selecionados através de revisão literária, tendo como referencial os domínios multiníveis do Modelo Social Ecológico Modificado, categorizados em componentes socioestruturais e comportamentais. O conteúdo foi avaliado por especialistas em duas rodadas conduzidas pela técnica Delphi, admitindo-se um índice de concordância de, no mínimo, 80%. Resultados a primeira versão do instrumento continha 52 itens, distribuídos em três domínios. Na primeira rodada, 19 itens (36,5%) obtiveram Índice de Validade de Conteúdo inferior a 0,80, dois itens foram excluídos e os demais foram reformulados. Na segunda rodada, 2 itens foram excluídos e 3 foram incorporados como subitem, totalizando 45 itens. O Índice de Validade de Conteúdo do Instrumento foi de 95%. Conclusão e implicações para a prática as recomendações dos especialistas contribuíram para a qualificação do instrumento Avaliação Socioestrutural e Comportamental-HIV, possibilitando a reorganização do conteúdo. O instrumento é válido para a identificação de fatores socioestruturais e comportamentais associados à infecção pelo HIV em jovens, com potencial para constituir planejamento de cuidados preventivos. jovens metodológico etapas literária Modificado Delphi admitindose admitindo se mínimo 80 80% 5 rodada 1 36,5% 365 36 (36,5% 080 0 0,80 reformulados subitem 4 95 95% ComportamentalHIV, ComportamentalHIV Comportamental HIV, Comportamental-HIV preventivos 8 36,5 (36,5 08 0,8 9 36, (36, 0, (36 (3 (

Abstract Humans are exposed to natural compounds such as phytoestrogens primarily through diet and supplements. These compounds promote health by alleviating the symptoms and illnesses associated with menopause and arthritis. Diosgenin (DSG) occurs naturally in plants such as Dioscorea villosa (DV) and binds to estrogen receptors, so it may have similar effects to this hormone, including against arthritis. Thus, we investigated the effect of chronic treatment with dry extract of DV and its phytoestrogen DSG on ovariectomized mice with arthritis. We found that dry extract of Dioscorea villosa (DV) contains the phytoestrogen diosgenin (DSG) in its composition. Furthermore, arthritic mice treated with DV and DSG showed reduced neutrophil accumulation in the articular cartilage. Also, the dry extract of DV administered orally (v.o) did not alter the leukocyte count in the joints or promote changes in the reproductive tract. However, DSG altered these parameters, with possible beneficial effects by reducing symptoms related to reproductive aging. Thus, oral treatment with dry extract of DV and subcutaneous (s.c) treatment with DSG showed promise by acting against inflammation caused by arthritis and reducing symptoms in the reproductive tract due to menopause. supplements (DSG (DV receptors hormone Thus composition Furthermore cartilage Also v.o vo v o (v.o However parameters aging s.c sc s c (s.c

RESUMEN Objetivos: evaluar los factores de riesgo del exceso de volumen de líquido en pacientes en hemodiálisis. Métodos: estudio retrospectivo de casos y controles. Se incluyeron 392 pacientes (196 casos y 196 controles) de dos centros de hemodiálisis. Se evaluaron datos sociodemográficos y 23 factores de riesgo de exceso de volumen de líquido mediante un formulario de recolección de datos. Los datos se analizaron mediante un modelo de regresión logística multivariado. Resultados: factores de riesgo conocimiento insuficiente (OR=2,06), ingesta excesiva de líquidos (OR=2,33), retirada inadecuada de líquidos durante la hemodiálisis (OR=2,62) e ingesta excesiva de sodio (OR=1,91) pueden aumentar aproximadamente dos veces la posibilidad de que se produzca un exceso de volumen de líquido en pacientes en hemodiálisis. La educación (OR=0,95) y la edad (OR=0,97) son factores protectores del volumen excesivo de líquido. Conclusiones: conocer estos factores de riesgo puede ayudar a las enfermeras a realizar una inferencia diagnóstica precisa y rápida del riesgo de volumen excesivo de líquidos. Objetivos Métodos controles 39 (19 19 2 multivariado Resultados OR=2,06, OR206 OR OR=2,06 , 06 (OR=2,06) OR=2,33, OR233 OR=2,33 33 (OR=2,33) OR=2,62 OR262 62 (OR=2,62 OR=1,91 OR191 1 91 (OR=1,91 OR=0,95 OR095 0 95 (OR=0,95 OR=0,97 OR097 97 (OR=0,97 Conclusiones 3 (1 OR20 OR=2,0 (OR=2,06 OR23 OR=2,3 (OR=2,33 OR=2,6 OR26 6 (OR=2,6 OR=1,9 OR19 9 (OR=1,9 OR=0,9 OR09 (OR=0,9 ( OR2 OR=2, (OR=2,0 (OR=2,3 (OR=2, OR=1, OR1 (OR=1, OR=0, OR0 (OR=0, OR=2 (OR=2 OR=1 (OR=1 OR=0 (OR=0 OR= (OR= (OR

ABSTRACT Objectives: to assess risk factors for excess fluid volume in hemodialysis patients. Methods: a retrospective case-control study was conducted. A total of 392 patients (196 cases and 196 controls) from two hemodialysis centers were included. Sociodemographic data and 23 risk factors for excess fluid volume were assessed using a data collection form. Data were analyzed using a multivariate logistic regression model. Results: the insufficient knowledge (OR=2.06), excessive fluid intake (OR=2.33), inadequate fluid removal during hemodialysis (OR=2.62) and excessive sodium intake (OR=1.91) risk factors may increase the chance of occurrence of excess fluid volume in hemodialysis patients by approximately two times. Education level (OR=0.95) and age (OR=0.97) are protective factors for excessive fluid volume. Conclusions: knowing these risk factors may help nurses with accurate and rapid diagnostic inference of the risk of excessive fluid volume. Objectives Methods casecontrol case control conducted 39 (19 19 controls included 2 form model Results OR=2.06, OR206 OR OR=2.06 , 06 (OR=2.06) OR=2.33, OR233 OR=2.33 33 (OR=2.33) OR=2.62 OR262 62 (OR=2.62 OR=1.91 OR191 1 91 (OR=1.91 times OR=0.95 OR095 0 95 (OR=0.95 OR=0.97 OR097 97 (OR=0.97 Conclusions 3 (1 OR20 OR=2.0 (OR=2.06 OR23 OR=2.3 (OR=2.33 OR=2.6 OR26 6 (OR=2.6 OR=1.9 OR19 9 (OR=1.9 OR=0.9 OR09 (OR=0.9 ( OR2 OR=2. (OR=2.0 (OR=2.3 (OR=2. OR=1. OR1 (OR=1. OR=0. OR0 (OR=0. OR=2 (OR=2 OR=1 (OR=1 OR=0 (OR=0 OR= (OR= (OR

RESUMO Objetivos: avaliar os fatores de risco para o excesso de volume de líquidos em pacientes em hemodiálise. Métodos: estudo retrospectivo caso-controle. Foram incluídos 392 pacientes (196 casos e 196 controles) de dois centros de hemodiálise. Dados sociodemográficos e 23 fatores de risco para excesso de volume de líquidos foram avaliados por meio de formulário de coleta de dados. Os dados foram analisados por meio de modelo de regressão logística multivariada. Resultados: os fatores de risco conhecimento insuficiente (OR=2,06), ingestão excessiva de líquidos (OR=2,33), retirada inadequada de líquidos durante hemodiálise (OR=2,62) e ingestão excessiva de sódio (OR=1,91) podem aumentar a chance de ocorrência de excesso de líquidos volume em pacientes em hemodiálise em aproximadamente duas vezes. Escolaridade (OR=0,95) e idade (OR=0,97) são fatores de proteção para volume excessivo de líquidos. Conclusões: conhecer esses fatores de risco pode auxiliar enfermeiros na inferência diagnóstica precisa e rápida do risco de volume excessivo de líquidos. Objetivos Métodos casocontrole. casocontrole caso controle. controle caso-controle 39 (19 19 controles 2 multivariada Resultados OR=2,06, OR206 OR OR=2,06 , 06 (OR=2,06) OR=2,33, OR233 OR=2,33 33 (OR=2,33) OR=2,62 OR262 62 (OR=2,62 OR=1,91 OR191 1 91 (OR=1,91 vezes OR=0,95 OR095 0 95 (OR=0,95 OR=0,97 OR097 97 (OR=0,97 Conclusões 3 (1 OR20 OR=2,0 (OR=2,06 OR23 OR=2,3 (OR=2,33 OR=2,6 OR26 6 (OR=2,6 OR=1,9 OR19 9 (OR=1,9 OR=0,9 OR09 (OR=0,9 ( OR2 OR=2, (OR=2,0 (OR=2,3 (OR=2, OR=1, OR1 (OR=1, OR=0, OR0 (OR=0, OR=2 (OR=2 OR=1 (OR=1 OR=0 (OR=0 OR= (OR= (OR

ABSTRACT Objective Patients with cancer often undergo multiple extended treatments that decrease their quality of life. However, the quality of life of women with breast cancer after they undergo treatment remains underexplored in Brazil. Therefore, this study determined sociodemographic, behavioral, and clinical factors related to the post-treatment quality of life of women with breast cancer. Methods This cross-sectional study involved 101 women diagnosed with breast cancer between 2014 and 2016 and treated at a Brazilian Oncology Reference Service. Data were collected from them using face-to-face surveys. Quality of life was evaluated using the European Organization for the Research and Treatment of Cancer Core Quality of Life questionnaire (EORTC QLQ-C30) and EORTC Breast Cancer-specific Quality of Life questionnaire (EORTC QLQ-BR23). The data collected were analyzed using Student’s t-test and Mann-Whitney U test. Results The median score on the global health, functional, and symptom scales of the EORTC QLQ-C30 was 75.00 (Interquartile range=33.33), 75.99 (Standard deviation [SD]=19.26), and 19.67 (SD=16.91), respectively. The mean score on the functional and symptom scales of the EORTC QLQ-BR23 was 61.89 (SD=17.21) and 20.12 (SD=16.94), respectively. Furthermore, higher post-treatment quality of life was found to be associated with being aged 50 or more, being Black, having eight or more years of education, having a partner, having a paying job, receiving treatment from the private healthcare system, having a higher income, living in the municipality where healthcare services are availed, engaging in physical activity, not smoking, being more religious, having more social support, not being overweight, having no comorbidities, and undergoing lumpectomy. Conclusion Sociodemographic, behavioral, and clinical factors significantly impact the quality of life of women who undergo breast cancer treatment. Implementing interventions that improve health and reducing inequalities in the access to healthcare services can improve the quality of life of these patients. However Brazil Therefore sociodemographic behavioral posttreatment post crosssectional cross sectional 10 201 Service facetoface face surveys QLQC30 QLQC QLQ C30 C Cancerspecific specific QLQBR23. QLQBR23 QLQBR BR23 . BR QLQ-BR23) Students Student s ttest t test MannWhitney Mann Whitney QLQ-C3 7500 75 00 75.0 Interquartile range=33.33, range3333 range range=33.33 , 33 range=33.33) 7599 99 75.9 Standard SD=19.26, SD1926 SD =19.26 19 26 [SD]=19.26) 1967 67 19.6 SD=16.91, SD1691 SD=16.91 16 91 (SD=16.91) respectively QLQ-BR2 6189 61 89 61.8 SD=17.21 SD1721 17 21 (SD=17.21 2012 20 12 20.1 SD=16.94, SD1694 SD=16.94 94 (SD=16.94) Furthermore 5 Black education partner job system income availed activity smoking religious support overweight comorbidities lumpectomy Sociodemographic patients 1 QLQC3 C3 QLQBR2 BR2 QLQ-C 750 7 0 75. range333 range=33.3 3 759 9 SD=19.26 SD192 1926 =19.2 2 [SD]=19.26 196 6 19. SD169 SD=16.9 (SD=16.91 QLQ-BR 618 8 61. SD=17.2 SD172 (SD=17.2 20. (SD=16.94 range33 range=33. SD=19.2 SD19 192 =19. [SD]=19.2 SD16 SD=16. (SD=16.9 SD=17. SD17 (SD=17. range3 range=33 SD=19. SD1 =19 [SD]=19. SD=16 (SD=16. SD=17 (SD=17 range=3 SD=19 =1 [SD]=19 SD=1 (SD=16 (SD=1 range= = [SD]=1 SD= (SD= [SD]= (SD [SD] [SD

ABSTRACT This article focuses on the discussion of the results obtained with non-invasive image and spectroscopic analyzes (to determine chemical elements and compounds) on the six paintings by the German artist, naturalized Italian, Massimo Campigli, that belong to the collection of the Museum of Contemporary Art of the University of São Paulo (MAC USP). Aspects of the artist’s trajectory, the plastic solutions of the artworks, along with the analyzes made with the spectroscopic techniques of energy dispersive X-ray fluorescence (ED-XRF), Raman, and Fourier transform infrared (FTIR), and the imaging techniques of visible photography (VIS), raking light (RAK), transmitted light (TRANS), visible ultraviolet fluorescence (UVF), infrared reflectography (IRR), and radiography (RAD) offer important information on the artist and on his work. These non-invasive analyzes were carried out in the museum itself with portable equipment from the Laboratory of Archaeometry and Applied Sciences to Cultural Heritage (LACAPC) of the Physics Institute (IF) of USP. Overall, the results obtained corroborate with Campigli’s testimonies about his artistic practice, as well as those of people who saw him working in his studio. His palette choice, composed by natural and synthetic pigments, mostly whites and paints with earthy tones, and his creative steps of creating and recreating the paintings, reusing canvases many times, were proven to be true with the analytical investigations. noninvasive non invasive compounds Italian Campigli MAC USP . USP) artists s trajectory artworks Xray X ray EDXRF, EDXRF ED XRF , (ED-XRF) Raman FTIR, FTIR (FTIR) VIS, VIS (VIS) RAK, RAK (RAK) TRANS, TRANS (TRANS) UVF, UVF (UVF) IRR, IRR (IRR) RAD (RAD work LACAPC (LACAPC IF (IF Overall Campiglis practice studio choice pigments tones times investigations (ED-XRF (FTIR (VIS (RAK (TRANS (UVF (IRR

RESUMO O presente artigo discute os resultados obtidos com as análises de imagens e espectroscópicas (para determinação dos elementos e compostos químicos) não invasivas realizadas em seis pinturas do artista alemão, naturalizado italiano, Massimo Campigli pertencentes ao acervo do Museu de Arte Contemporânea da Universidade de São Paulo (MAC USP). Os aspectos da trajetória do artista, as soluções plásticas das obras somadas às análises feitas com técnicas espectroscópicas de fluorescência de raios X por dispersão de energia (FRX-DE), Raman, e infravermelho com transformada de Fourier (FTIR), e com técnicas de imageamento como fotografia sob luz visível (VIS), luz rasante (RAS), luz transmitida (TRANS), fluorescência visível induzida por radiação ultravioleta (UV-VIS), reflectografia de infravermelho (RIV) e radiografia (RAD) fornecem importantes informações sobre o artista e sua obra. As técnicas analíticas não invasivas foram realizadas no próprio museu e com equipamentos portáteis do Laboratório de Arqueometria e Ciências Aplicadas ao Patrimônio Cultural (LACAPC) do Instituto de Física (IF) da USP. No geral, os resultados obtidos corroboram com os testemunhos de Campigli sobre o seu fazer artístico, assim como daqueles que o viram trabalhando no ateliê. A sua escolha de paleta, composta por pigmentos naturais e sintéticos, na sua maior parte brancos e tintas com tonalidades terrosas, e suas etapas produtivas de criar e recriar as pinturas, muitas vezes reutilizando telas, foram comprovadas através das investigações analíticas. para químicos alemão italiano MAC USP . USP) FRXDE, FRXDE FRX DE , (FRX-DE) Raman FTIR, FTIR (FTIR) VIS, VIS (VIS) RAS, RAS (RAS) TRANS, TRANS (TRANS) UVVIS, UVVIS UV (UV-VIS) RIV (RIV RAD (RAD obra LACAPC (LACAPC IF (IF geral artístico ateliê paleta sintéticos terrosas telas (FRX-DE (FTIR (VIS (RAS (TRANS (UV-VIS

ABSTRACT. The Spodoptera frugiperda, is one of the most deleterious pests of popcorn and the identification of resistant genotypes is determinant in breeding programs. The objective of this study was to select popcorn genotypes resistant to S. frugiperda and the key traits related to the identification of resistance. The popcorn varieties UEM J1, Composto Márcia, Arachida, Composto Gaúcho, and Zapalote Chico (resistant check) were evaluated in a completely randomized design with 100 replications. The experimental unit consisted of one Petri dish, containing plant material and a caterpillar The following traits were evaluated: larval stage duration (LSt), food intake weight(IW), final larva weight (FW), mean larva weight (MW), feces (F), assimilated (A) and metabolized food weight (M), relative consumption rate (RCR), relative metabolic rate (RMR), relative growth rate (RGR), conversion efficiency of ingested food (CEI), apparent digestibility (AD), conversion efficiency of digested food (CED), and leaf area consumed (LAC). The diagnosis of multicollinearity, analysis of canonical variables, genetic divergence, hierarchical clustering, factor analysis and canonical correspondence analysis were carried out to perform multivariate analysis. After the multicollinearity test, the traits FW, IW, RCR, AD, and LAC were maintained for further analysis. The traits IW, FW and AD were determinant in the resistance by antixenosis expressed by the varieties Zapalote Chico and Arachida, for the varieties Composto Gaúcho and Composto Márcia the determining characteristics were RCR and LAC and for the variety UEM J1 the variable LAC showed greater importance. Variety Arachida was considered resistant to S. frugiperda by antixenosis and can be used in the future as a source of favorable alleles to breed resistant popcorn hybrids. The traits relative consumption rate, apparent digestibility and leaf area consumed were considered key traits in the identification of resistance against S. frugiperda in popcorn genotypes. ABSTRACT programs S J check 10 replications dish LSt, LSt , (LSt) weightIW, weightIW IW weight(IW) (FW) MW, MW (MW) F, F (F) A (A M, M (M) (RCR) RMR, RMR (RMR) RGR, RGR (RGR) CEI, CEI (CEI) (AD) CED, CED (CED) LAC. . (LAC) variables divergence clustering test importance hybrids 1 (LSt weight(IW (FW (MW (F (M (RCR (RMR (RGR (CEI (AD (CED (LAC

Abstract Introduction: The PHEEM (postgraduate hospital educational environment measure) is a validated and reliable instrument to assess the educational environment in medical residency programs. Objective: To map the application of the PHEEM questionnaire in medical residency, evaluate the results found, positive and negative aspects and points for improvement. Method: We performed a scoping review according to the Joanna Briggs institution’s methodology. Studies that followed the PCC structure were included, as follows: P (participants) = resident physicians of any specialty; C (concept) = The PHEEM is an instrument used to assess the educational environment in medical residency, through a 40-item questionnaire divided into 3 subscales that include perception of autonomy, teaching and social support. C (context)= studies on PHEEM in medical residency of any specialty. PubMed, EMBASE and the Virtual Health Library databases were the data sources. Results: We identified 1588 references, and after reading the title and abstract, 50 references were selected for full reading, and 36 studies were included. The studies were carried out in 22 countries, and most revealed a more positive than negative educational environment, albeit with room for improvement. In the subscales, the perception of autonomy was more positive than negative, and the perception of teaching revealed that most programs are moving in the right direction. However, when evaluating social support, the results were divided between an unpleasant environment and an environment with more pros than cons. The main highlighted positive points were low racial and sexual discrimination, possibility of working in a team, adequate level of responsibilities, accessible teachers with good teaching skills, learning opportunities and participation in educational events. The main negative points were lack of adequate food and accommodation during the shifts, excessive workload, lack of feedback from preceptors and lack of protected time for study and the culture of blaming the resident. Conclusion: The application of PHEEM revealed that in most medical residency programs the educational environment was more positive than negative, albeit with room for improvement. Efforts are needed to improve the educational environment, especially social support, in medical residency programs. Introduction postgraduate measure Objective found improvement Method institutions institution s methodology included follows participants (participants specialty concept (concept 40item item 40 support context= context (context) PubMed sources Results 158 abstract 5 2 countries direction However cons discrimination team responsibilities skills events shifts workload Conclusion 4 (context 15 1

Resumo Introdução: O Postgraduate Hospital Educational Environment Measure (PHEEM) é um instrumento validado e confiável para avaliar o ambiente educacional nos programas de residência médica. Objetivo: Este estudo teve como objetivos mapear a aplicação do questionário PHEEM na residência médica e avaliar os resultados, os aspectos positivos e negativos e os pontos passíveis de melhoria. Método: Trata-se de uma revisão de escopo de acordo com a metodologia do Instituto Joanna Briggs de revisões de escopo. Foram incluídos estudos seguindo a estrutura PCC: P (participantes) = médicos residentes de qualquer especialidade; C (conceito) = o PHEEM é um instrumento utilizado para avaliar o ambiente educacional na residência médica, por meio de um questionário de 40 itens divididos em três subescalas que incluem percepção de autonomia, ensino e suporte social; C (cenário) = pesquisas sobre o PHEEM na residência médica de qualquer especialidade. As bases eletrônicas pesquisadas foram: PubMed, Embase e Biblioteca Virtual em Saúde (BVS). Resultado: As estratégias de busca rodadas resultaram em 1.588 estudos, 50 foram lidos na íntegra, e incluíram-se 36. Os estudos foram realizados em 22 países, e a maioria revelou um ambiente educacional mais positivo que negativo, entretanto com espaço para melhorias. Nas subescalas, a percepção de autonomia se mostrou mais positiva que negativa, e a percepção de ensino revelou que a maioria dos programas está caminhando na direção certa. Entretanto, na avaliação do suporte social, os resultados foram divididos entre um ambiente não agradável e um ambiente com mais prós do que contras. Os principais pontos positivos destacados foram baixa discriminação racial e sexual, possibilidade de trabalhar em equipe, nível adequado de responsabilidades, professores acessíveis e com boas habilidades de ensino, oportunidades de aprendizado e participação em eventos educacionais. Os principais pontos negativos foram falta de alimentação e acomodação adequadas durante o plantão, carga horária excessiva, falta de feedback por parte dos preceptores, falta de tempo protegido para estudo e cultura de culpar o residente. Conclusão: A aplicação do PHEEM revelou que, na maioria dos programas de residência médica, o ambiente educacional se mostrou mais positivo que negativo, entretanto com espaço para melhorias. São necessários esforços para a melhoria do ambiente educacional, especialmente do suporte social, nos programas de residência médica. Introdução (PHEEM Objetivo Método Tratase Trata PCC participantes (participantes especialidade conceito (conceito 4 social cenário (cenário PubMed BVS. BVS . (BVS) Resultado 1588 1 588 1.58 5 íntegra incluíramse incluíram 36 2 países negativo melhorias negativa certa Entretanto contras sexual equipe responsabilidades educacionais plantão excessiva preceptores residente Conclusão (BVS 158 58 1.5 3 15 1.

The compound 2-hydrazinyl-4-(4-methoxyphenyl)thiazole (PD76) is a novel thiazolyl hydrazine derivative with proven antifungal activity against different fungal species, mainly Candida and Cryptococcus. Considering the advantages of oral route for clinical therapy, the aim of this work was to evaluate the potential intestinal permeability of this new antifungal drug. For the quantitation of PD76, a high-performance liquid chromatography method was developed and fully validated. The cytotoxicity of the compound in Caco-2 cells was analyzed and intestinal permeability of PD76 was assessed by means of the comparison of in vitro assay in Caco-2 cells and in silico platforms ADMETlab and admetSAR. Cell viability above 70% was obtained at all PD76 studied concentrations. Using Caco-2 cell model, the compound showed apparent permeability coefficients (Papp) of 5.25 × 10-6 and 23.28 × 10-6 cm s-1 in apical-basolateral and basolateral-apical directions, respectively. Experiments performed using verapamil as P-gp inhibitor demonstrated that PD76 is slightly susceptible to active efflux. Both in silico platforms inferred that PD76 presents permeability in Caco-2 cells, with Log P values of 2.82 (ADMETlab) and 2.10 (admetSAR). The results obtained in permeability studies showed that PD76 presents moderate intestinal permeability and a promising profile for clinical application. 2hydrazinyl44methoxyphenylthiazole hydrazinylmethoxyphenylthiazole 2 hydrazinyl 4 methoxyphenyl thiazole PD (PD76 species Cryptococcus therapy drug highperformance high performance validated Caco2 Caco Caco- PD7 admetSAR 70 concentrations model Papp (Papp 525 5 25 5.2 106 10 6 10- 2328 23 28 23.2 s1 s 1 s- apicalbasolateral apical basolateral basolateralapical directions respectively Pgp gp efflux 282 82 2.8 (ADMETlab 210 2.1 . (admetSAR) application methoxyphenylthiazole (PD7 7 52 5. 232 23. 8 2. 21 (admetSAR (PD

Abstract Diabetes mellitus (DM) is a major cause of chronic kidney disease (CKD) and changes in lipoprotein. Literature data suggest that cholesterol associated with high-density lipoprotein (HDLc) plays a protective role against albuminuria and diabetic nephropathy. These factors are related with changes in serum apolipoproteins such Apo A-I. This work aims to evaluate the correlation of apolipoprotein A-I with renal function in diabetic outpatients. Samples were collected from 281 outpatients for analyses of glycated hemoglobin (HbA1c), serum creatinine (SCr), urea (BUN), cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDLc) and estimation of glomerular filtration rate (eGFR). Urinary samples were obtained to assess urine albumin creatinine ratio (UACR). Triglyceride-glucose index (TyG) was calculated to estimate insulin resistance. The mean age was 61,5 ± 16,4 years. Most patients were female, Afro-Mestizo and over 50 years of age. Pearson's revealed negative correlation of creatinine with HDLc and Apo A-I. There was a correlation of eGFR with HbA1c, TG and HDLc. TyG presented a negative correlation with Apo A-I and HDLc. The highest quartiles of UACR presented the highest TyG and the lowest Apo A-I. In conclusion, Apo A-I indicated an association with insulin resistance and changes in renal function parameters, especially as a factor associated with the onset of albuminuria, with a better predictive potential than the HDLc. DM (DM CKD (CKD highdensity high density (HDLc nephropathy AI. AI A I. I 28 HbA1c HbAc , HbA c (HbA1c) SCr, SCr (SCr) BUN, BUN (BUN) TC, TC (TC) TG, (TG) HDLcholesterol HDL eGFR. . (eGFR) UACR. (UACR) Triglycerideglucose Triglyceride glucose (TyG 615 61 5 61, 164 16 4 16, female AfroMestizo Afro Mestizo Pearsons Pearson s conclusion parameters 2 (HbA1c (SCr (BUN (TC (TG (eGFR (UACR 6 1

RESUMEN Objetivo: Construir una teoría de rango medio para el diagnóstico de enfermería Sobrepeso en adolescentes y adultos jóvenes. Métodos: Estudio metodológico a la luz de los marcos teóricos de Roy y de Lopes, Silva y Herdman. Un total de 3.925 artículos fueron recuperados y evaluados utilizando el software State of the Art Through Systematic Review. La muestra final fue de 28 artículos. Resultados: Los resultados convergieron en 3 atributos esenciales, 13 antecedentes y 7 consecuencias. Se construyó una teoría de rango medio compuesta por un diagrama ilustrado, 11 proposiciones y 12 relaciones causales. Consideraciones finales: A partir de la creación de la teoría, fue posible comprender mejor el diagnóstico de enfermería Sobrepeso en el contexto de adolescentes y adultos jóvenes. La comprensión de los fenómenos de enfermería contribuye para el avance y fortalecimiento de la ciencia de enfermería. Objetivo jóvenes Métodos Lopes Herdman 3925 925 3.92 Review 2 Resultados esenciales 1 consecuencias ilustrado causales finales 392 92 3.9 39 9 3.

ABSTRACT Objective: To build a mid-range theory for the nursing diagnosis Overweight in adolescents and young adults. Methods: A methodological study in the light of the theoretical frameworks of Roy and of Lopes, Silva and Herdman. A total of 3,925 articles were retrieved and assessed using the State of the Art Through Systematic Review software. The final sample consisted of 28 articles. Results: The findings converged to 3 essential attributes, 13 antecedents, and 7 consequences. A mid-range theory was built consisting of an illustrated diagram, 11 propositions, and 12 causal relationships. Final considerations: From the creation of the theory, it was possible to better understand the nursing diagnosis Overweight within the context of adolescents and young adults. Understanding nursing phenomena contributes to nursing science’s advancement and strengthening. Objective midrange mid range adults Methods Lopes Herdman 3925 925 3,92 software 2 Results attributes 1 antecedents consequences diagram propositions relationships considerations sciences science s strengthening 392 92 3,9 39 9 3,

RESUMO Objetivo: Construir uma teoria de médio alcance para o diagnóstico de enfermagem Sobrepeso em adolescentes e adultos jovens. Método: Estudo metodológico à luz dos referenciais teóricos de Roy e Lopes, Silva e Herdman. Um total de 3.925 artigos foram identificados e avaliados usando o programa State of the Art Through Systematic Review. A amostra final foi composta por 28 artigos. Resultados: Os achados convergiram para 3 atributos essenciais, 13 antecedentes e 7 consequentes. Foi construída uma teoria de médio alcance composta por um diagrama ilustrado, 11 proposições e 12 relações causais. Considerações finais: A partir da elaboração da teoria, foi possível compreender melhor o diagnóstico de enfermagem Sobrepeso no contexto de adolescentes e adultos jovens. A compreensão dos fenômenos da enfermagem contribui para o avanço e fortalecimento da ciência da enfermagem. Objetivo jovens Método Lopes Herdman 3925 925 3.92 Review 2 Resultados essenciais 1 consequentes ilustrado causais finais 392 92 3.9 39 9 3.

Abstract This prospective study aims to evaluate dental pain, anxiety, and catastrophizing levels in pregnant women undergoing root canal treatment. Sixty pregnant and non-pregnant women presenting dental pain and an indication for root canal treatment were included in the study. Dental anxiety and catastrophizing were investigated using validated questionnaires. The endodontic intervention was performed, and a numerical scale measured preoperative and postoperative dental pain. The results were analyzed using STATA software 12.0. Unadjusted analyses assessed the association between pregnancy and pain, anxiety, and catastrophizing levels. Multiple linear regression models using ‘forward stepwise’ entry procedures were used to assess the independent effects of variables on pain scores. The significance level was set at 0.05. Initially, most patients experienced intense dental pain. The levels of dental pain, dental anxiety, and catastrophizing did not differ between pregnant and non-pregnant women. Logistic regression showed that postoperative pain was associated with irreversible pulpitis diagnosis (OR = 4.78; 95%CI 1.55–13.55) and high catastrophizing levels (OR = 1.96; 95%CI 1.01–3.84). Preoperative and postoperative pain rates and anxiety and catastrophizing were similar between pregnant and non-pregnant patients. Postoperative pain was associated with irreversible pulpitis diagnosis and high catastrophizing levels. The similarity between pregnant and non-pregnant women regarding preoperative and postoperative dental pain and catastrophizing and anxiety levels supports the indication of root canal treatment during the gestational period whenever necessary. nonpregnant non questionnaires performed 120 12 0 12.0 forward stepwise scores 005 05 0.05 Initially OR 4.78 478 4 78 95CI CI 95 1.55–13.55 1551355 1 55 13 1.96 196 96 1.01–3.84. 101384 1.01–3.84 . 01 3 84 1.01–3.84) necessary 12. 00 0.0 4.7 47 7 9 1.55–13.5 155135 5 1.9 19 10138 1.01–3.8 8 0. 4. 1.55–13. 15513 1. 1013 1.01–3. 1.55–13 1551 101 1.01–3 1.55–1 155 10 1.01– 1.55– 15 1.01 1.55 1.0 1.5

Abstract Patient Blood Management (PBM) is a holistic approach to managing blood as a resource of each patient; it is a multimodal strategy that is implemented using a set of techniques that can be applied in individual cases. In fact, the overall result of the implementation of PBM cannot be fully appreciated or explained by simply summing up the effects of the individual strategies and techniques used, since they can only produce the expected ideal result if combined. Implementing a PBM program in healthcare offers several benefits including improved patient safety, better outcomes, cost savings, conservation of resources, evidence-based practice, transfusion alternatives, improved quality of care, compliance with accreditation standards, patient-centered care, and professional education and training. (PBM cases fact used combined safety outcomes savings resources evidencebased evidence based practice alternatives care standards patientcentered centered training