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RESUMO: Escherichia coli é reconhecida como um dos principais microrganismos responsáveis pelo desencadeamento da mastite clínica, doença que causa perdas econômicas consideráveis na indústria de laticínios. Neste contexto, este estudo teve como objetivo principal a identificação de isolados de E. coli presentes em amostras individuais de leite coletadas de vacas com diagnóstico de mastite clínica, de diversas regiões do Brasil. Adicionalmente, por reação em cadeia da polimerase (PCR), foi investigada a presença dos genes de virulência eae, bfpB, escN, aatA, aggR, ipaH, stx1, stx2, est e eltA, todos associados aos patótipos de E. coli diarreiogênica (DEC). Como parte integrante do estudo, foi realizada uma avaliação abrangente do perfil de sensibilidade dos isolados a 11 antimicrobianos diferentes amplamente utilizados no tratamento da mastite. Foram coletadas 198 amostras de leite de vacas com diagnóstico de mastite clínica. Dentre essas amostras, 12 isolados (6,07%) demonstraram crescimento bacteriano superior a três Unidades Formadoras de Colônia (UFC) quando cultivadas em meio ágar MacConkey e características morfológicas de E. coli. Para avaliar a suscetibilidade desses isolados aos antimicrobianos foi utilizado o teste de disco-difusão, sendo observada a resistência mais predominante em relação à estreptomicina e à tetraciclina, afetando 16,67% das cepas analisadas. É relevante ressaltar que todos os isolados investigados não demonstraram a presença dos genes eae, aatA, aggR, ipaH, stx1, stx2, est e eltA. Estes resultados indicam que estes isolados não se enquadram nos patótipos conhecidos como Escherichia coli diarreiogénica (DEC). Porém, um dos isolados testados apresentou positividade para os genes bfpB e escN. A detecção de E. coli resistente associada à mastite clínica aponta para possíveis lacunas no tratamento da doença. Além disso, a presença de genes de resistência em estirpes de E. coli indica a capacidade potencial de transmitir estes genes entre animais e talvez ao longo da cadeia alimentar. RESUMO laticínios contexto E Brasil Adicionalmente PCR, PCR , (PCR) eae escN aatA aggR ipaH stx1 stx stx2 eltA DEC. DEC . (DEC) 1 19 6,07% 607 6 07 (6,07% UFC (UFC discodifusão, discodifusão disco difusão, difusão disco-difusão tetraciclina 1667 16 67 16,67 analisadas Porém disso alimentar (PCR (DEC 6,07 60 0 (6,07 166 16,6 6,0 (6,0 16, 6, (6, (6 (

ABSTRACT: Escherichia coli is recognized as one of the main microorganisms responsible for triggering clinical mastitis, a disease that causes considerable economic losses in the dairy industry. In this context, this study aimed to identify E. coli isolates present in individual milk samples collected from cows diagnosed with clinical mastitis from various regions of Brazil. Additionally, through polymerase chain reaction (PCR), the presence of virulence genes eae, bfpB, escN, aatA, aggR, ipaH, stx1, stx2, est, and eltA was investigated; all associated with the pathotypes of diarrheagenic Escherichia coli (DEC). As an integral part of the study, a comprehensive assessment of the sensitivity profile of the isolates to 11 different antimicrobials widely used in mastitis treatment was also conducted. A total of 198 milk samples were collected from cows diagnosed with clinical mastitis. Among these samples, 12 isolates (6.07%) demonstrated bacterial growth greater than three Colony-Forming Units (CFU) when grown on MacConkey agar medium and morphological characteristics of E. coli. The disc-diffusion test was used to evaluate the susceptibility of these isolates to antimicrobials, and the most predominant resistance was observed concerning streptomycin and tetracycline, affecting 16.67% of the strains analyzed. Notably, all isolates investigated did not demonstrate the presence of the genes eae, aatA, aggR, ipaH, stx1, stx2, est, and eltA. These results indicate that these isolates do not fit the pathotypes known as diarrheagenic Escherichia coli (DEC). However, one of the isolates tested was positive for the bfpB and escN genes. The detection of resistant E. coli associated with clinical mastitis points to possible gaps in the treatment of the disease. Additionally, the presence of resistance genes in E. coli strains indicates the potential to transmit these genes between animals and, perhaps, along the food chain. ABSTRACT industry context E Brazil Additionally PCR, PCR , (PCR) eae aatA aggR ipaH stx1 stx stx2 est DEC. DEC . (DEC) 1 conducted 19 6.07% 607 6 07 (6.07% ColonyForming Colony Forming CFU (CFU discdiffusion disc diffusion tetracycline 1667 16 67 16.67 analyzed Notably However perhaps (PCR (DEC 6.07 60 0 (6.07 166 16.6 6.0 (6.0 16. 6. (6. (6 (

https://doi.org/10.1590/1678-5150-pvb-7430

Mortality, hospitalizations, and persistence of symptoms in the outpatient setting of the first COVID-19 wave in Brazil: results of SARS-Brazil cohort study Mortality hospitalizations COVID19 COVID 19 COVID-1 Brazil SARSBrazil SARS COVID1 1 COVID-
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Fonseca, Henrique Andrade Rodrigues

; Pereira, Adriano Jose

; Nawa, Ricardo Kenji

; Sant’Anna, Viviane Aparecida Rodrigues

; Almeida, Tatiana Ferreira de

; Guimarães, Hélio Penna

; Tognon, Alexandre Pereira

; Marques, Lucas Miranda

; Silva, Lucas Santana Coelho da

; Bittencourt, Rafaela de Souza

; Gomes, Camila Pachêco

; Martins, Priscila de Aquino

; Oliveira, Aryadne Lyrio de

; Milan, Eveline Pipolo

; Dall’Orto, Frederico Toledo Campos

; Hoffman Filho, Conrado Roberto

; Almeida, Guacyra

; Hohmann, Fábio Barlem

; Moia, Diogo Duarte Fagundes

; Piano, Luciana Pereira Almeida

; Machado, Felipe Pinheiro

; Soares, Ronaldo Vicente Pereira

; Damiani, Lucas Petri

; Assis, Silvia Regina Lamas

; Amaro Junior, Edson

; Rizzo, Luiz Vicente

; Berwanger, Otávio

einstein (São Paulo)

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2024, Volume 22 elocation eAO0652

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective To evaluate deaths, hospitalizations, and persistence of symptoms in patients with COVID-19 after infection in an outpatient setting during the first COVID-19 wave in Brazil. Methods This prospective cohort was between April 2020 and February 2021. Hospitalized or non-hospitalized COVID-19 patients until five days after symptom onset were included. The outcomes measured were incidence of death, hospitalization, and persistence of more than two symptoms 60 days after discharge. Results Out of 1,198 patients enrolled in the study, 66.7% were hospitalized. A total of 289 patients died (1 [0.3%] non-hospitalized and 288 [36%] hospitalized). At 60 days, patients non-hospitalized during admission had more persistent symptoms (16.2%) compared to hospitalized (37.1%). The COVID-19 severity variables associated with the persistence of two or more symptoms were increased age (OR= 1.03; p=0.015), respiratory rate at hospital admission (OR= 1.11; p=0.005), length of hospital stay of more than 60 days (OR= 12.24; p=0.026), and need for intensive care unit admission (OR= 2.04; p=0.038). Conclusion COVID-19 survivors who were older, tachypneic at admission, had a hospital length of stay >60 days, and were admitted to the intensive care unit had more persistent symptoms than patients who did not require hospitalization in the early COVID-19 waves. ClinicalTrials.gov Identifier: NCT04479488. deaths hospitalizations COVID19 COVID 19 COVID-1 Brazil 202 2021 nonhospitalized non included death 6 discharge 1198 1 198 1,19 study 667 66 7 66.7 28 ( 0.3% 03 0 3 [0.3% 36% 36 [36% . hospitalized) 16.2% 162 16 2 (16.2% 37.1%. 371 37.1% 37 (37.1%) OR= OR (OR 1.03 103 p=0.015, p0015 p p=0.015 , 015 p=0.015) 1.11 111 11 p=0.005, p0005 p=0.005 005 p=0.005) 12.24 1224 12 24 p=0.026, p0026 p=0.026 026 p=0.026) 2.04 204 04 p=0.038. p0038 p=0.038 038 p=0.038) older >6 waves ClinicalTrialsgov ClinicalTrials gov Identifier NCT04479488 NCT COVID1 COVID- 20 119 1,1 66. 0.3 [0.3 [36 16.2 (16.2 37.1 (37.1% 1.0 10 p001 p=0.01 01 1.1 p000 p=0.00 00 12.2 122 p002 p=0.02 02 2.0 p003 p=0.03 > NCT0447948 1, 0. [0. [3 16. (16. 37. (37.1 1. p00 p=0.0 12. 2. NCT044794 [0 [ (16 (37. p0 p=0. NCT04479 (37 p=0 NCT0447 (3 p= NCT044 NCT04 NCT0

https://doi.org/10.31744/einstein_journal/2024ao0652

Gamasoidosis (avian mite dermatitis) outbreak in a student dormitory avian dermatitis
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Minagawa, Fernando Hiroshi

; Almeida, Ettore Rafael Mai

; Souza, Rafaela Caroline de

; Santos, Daniela Carvalho dos

; Haddad Junior, Vidal

; Miot, Hélio Amante

Revista da Sociedade Brasileira de Medicina Tropical

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2024, Volume 57 elocation e01101-2024

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/0037-8682-0228-2024

Chorea secondary to human immunodeficiency virus infection
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Franzoi, André Eduardo de Almeida

; Maieski, Amanda

; Disserol, Caio César Diniz

; Teive, Helio Afonso Ghizoni

Arquivos de Neuro-Psiquiatria

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Set 2023, Volume 81 Nº 9 Páginas 857 - 858

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1055/s-0043-1771170

Female-pattern hair loss: therapeutic update
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Ramos, Paulo Müller

; Melo, Daniel Fernandes

; Radwanski, Henrique

; Almeida, Rita Fernanda Cortez de

; Miot, Hélio Amante

Anais Brasileiros de Dermatologia

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Ago 2023, Volume 98 Nº 4 Páginas 506 - 519

Resumo: En | Texto: En | PDF: En

Abstract Female androgenetic alopecia or female-pattern hair loss (FPHL) is highly prevalent and has a great impact on the quality of life. The treatment is a routine challenge in dermatological practice, as many therapeutic options have a limited level of evidence and often do not meet patients expectations. Lack of knowledge of the pathogenesis of the hair miniaturization process and the factors that regulate follicular morphogenesis restricts the prospect of innovative therapies. There is also a lack of randomized, controlled studies with longitudinal follow-up, using objective outcomes and exploring the performance of the available treatments and their combinations. Topical minoxidil, which has been used to treat female pattern hair loss since the 1990s, is the only medication that has a high level of evidence and remains the first choice. However, about 40% of patients do not show improvement with this treatment. In this article, the authors critically discuss the main clinical and surgical therapeutic alternatives for FPHL, as well as present camouflage methods that can be used in more extensive or unresponsive cases.

https://doi.org/10.1016/j.abd.2022.09.006

Case for diagnosis. Vascular malformations, hemihypertrophy and macrodactyly: Proteus syndrome diagnosis malformations macrodactyly
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Barbosa, Bárbara Elias do Carmo

; Alfredo, Melissa de Almeida Corrêa

; Abbade, Luciana Patrícia Fernandes

; Miot, Hélio Amante

Anais Brasileiros de Dermatologia

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Jun 2023, Volume 98 Nº 3 Páginas 384 - 386

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1016/j.abd.2021.11.012

Challenges of Multidrug-resistant New Delhi Metallo-beta-Lactamase (NDM-1)-producing Enterobacteriaceae in Kidney Transplant Patients Multidrugresistant Multidrug resistant MetallobetaLactamase Metallo beta Lactamase NDM1producing NDMproducing NDM 1 producing
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Foresto, Renato Demarchi

; Menezes, Lucas Marengo

; Nishimura, Laura Tomoko

; Cristelli, Marina Pontello

; Viana, Laila Almeida

; Santos, Daniel Wagner de Castro Lima

; Requião-Moura, Lúcio R.

; Tedesco-Silva, Helio

; Medina-Pestana, Jose

Brazilian Journal of Nephrology

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Mar 2023, Volume 45 Nº 1 Páginas 116 - 120

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Histórico: O surgimento de cepas multirresistentes de enterobacteriaceae produtoras de NDM-1 tornou-se uma ameaça para pacientes hospitalizados, especialmente para os imunossuprimidos, como os receptores de transplante renal. NDM-1 é uma carbapenemase que torna as bactérias gram-negativas resistentes a muitos tipos de antibióticos. A incidência de infecção por enterobactérias produtoras de carbapenemas em receptores de transplante de órgãos sólidos é de cerca de 3 a 10%, com uma taxa de mortalidade de até 30%. Métodos: Apresentamos uma série de casos de 4 pacientes com enterobactérias produtoras de NDM-1 isoladas em culturas de urina ou esfregaços retais. Também realizamos um estudo transversal 30 dias após a identificação do paciente, coletando culturas de vigilância (esfregaço retal) de todos os pacientes internados para avaliar a extensão de disseminação deste mecanismo de resistência; foram incluídos um total de 101 pacientes. Resultados: Dois pacientes foram tratados adequadamente com culturas de controle negativo. Os outros dois pacientes não foram tratados porque eram assintomáticos e tiveram culturas de urina negativas subsequentes. Não foi identificada nenhuma nova colonização na triagem transversal, e não foram registrados novos casos de infecção urinária por NDM-1 após um acompanhamento de 4 anos. Conclusão: A vigilância de infecções causadas por cepas multirresistentes em hospitais que tratam pacientes imunossuprimidos deve ser continuada e devem ser tomadas medidas imediatas em casos de surtos desses tipos de infecções. Histórico NDM1 NDM 1 NDM- tornouse tornou se hospitalizados renal gramnegativas gram antibióticos 10 10% 30% Métodos retais paciente esfregaço retal resistência Resultados negativo subsequentes anos Conclusão

Abstract Background: The emergence of multidrug-resistant NDM-1-producing enterobacteriaceae strains has become a threat to inpatients, especially to immunosuppressed ones, such as kidney transplant recipients. NDM-1 is a carbapenemase that makes gram-negative bacteria resistant to many types of antibiotics. The incidence of carbapenemase-producing enterobacteria infection in solid organ transplant recipients is around 3 to 10%, with a mortality rate of up to 30%. Methods: We present a case series of 4 patients with NDM-1-producing enterobacteria isolated in urine cultures or rectal swabs. We also conducted a cross-sectional study 30 days after patient identification, collecting surveillance cultures (rectal swab) from all inpatients to assess the extent of spread of this resistance mechanism; a total of 101 patients were included. Results: Two patients were adequately treated with negative control cultures. The other two patients were not treated because they were asymptomatic and had subsequent negative urine cultures. No new colonization was identified in the cross-sectional screening, and no new cases of urinary NDM-1 infection were recorded after a 4-year follow-up. Conclusion: Surveillance for infections caused by multidrug-resistant strains in hospitals treating immunosuppressed patients should be continued and prompt action should be taken in cases of outbreaks of multidrug-resistant infections. Background multidrugresistant multidrug NDM1producing NDMproducing NDM 1 producing ones NDM1 NDM- gramnegative gram antibiotics carbapenemaseproducing 10 10% 30% Methods swabs crosssectional cross sectional identification swab mechanism included Results screening 4year year followup. followup follow up. follow-up Conclusion

https://doi.org/10.1590/2175-8239-jbn-2021-0033

Diretriz Brasileira de Dispositivos Cardíacos Eletrônicos Implantáveis – 2023 202 20 2
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Teixeira, Ricardo Alkmim

; Fagundes, Alexsandro Alves

; Baggio Junior, José Mário

; Oliveira, Júlio César de

; Medeiros, Paulo de Tarso Jorge

; Valdigem, Bruno Pereira

; Teno, Luiz Antônio Castilho

; Silva, Rodrigo Tavares

; Melo, Celso Salgado de

; Elias Neto, Jorge

; Moraes Júnior, Antonio Vitor

; Pedrosa, Anisio Alexandre Andrade

; Porto, Fernando Mello

; Brito Júnior, Hélio Lima de

; Souza, Thiago Gonçalves Schroder e

; Mateos, José Carlos Pachón

; Moraes, Luis Gustavo Belo de

; Forno, Alexander Romeno Janner Dal

; D’Avila, Andre Luiz Buchele

; Cavaco, Diogo Alberto de Magalhães

; Kuniyoshi, Ricardo Ryoshim

; Pimentel, Mauricio

; Camanho, Luiz Eduardo Montenegro

; Saad, Eduardo Benchimol

; Zimerman, Leandro Ioschpe

; Oliveira, Eduardo Bartholomay

; Scanavacca, Mauricio Ibrahim

; Martinelli Filho, Martino

; Lima, Carlos Eduardo Batista de

; Peixoto, Giselle de Lima

; Darrieux, Francisco Carlos da Costa Duarte, Jussara de Oliveira Pinheiro Galvão Filho, Silas dos Santos Costa, Eduardo Rodrigues Bento Mateo, Enrique Indalécio Pachón Melo, Sissy Lara De Rodrigues, Thiago da Rocha Rocha, Eduardo Arrais Hachul, Denise Tessariol Lorga Filho, Adalberto Menezes Nishioka, Silvana Angelina D’Orio Gadelha, Eduardo Barreto Costa, Roberto Andrade, Veridiana Silva de Torres, Gustavo Gomes Oliveira Neto, Nestor Rodrigues de Lucchese, Fernando Antonio Murad, Henrique Wanderley Neto, José Brofman, Paulo Roberto Slud Almeida, Rui M. S. Leal, João Carlos Ferreira

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 1 elocation e20220892

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.36660/abc.20220892

10.

Growth and macronutrient accumulation in tomato cultivated in an organic system
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Almeida, Luciana G de

; Cardoso, Antonio Ismael Inácio

; Candian, Joara S

; Grassi Filho, Helio

; Sartori, Maria Márcia P

Horticultura Brasileira

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2023, Volume 41 elocation e2532

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo desta pesquisa foi caracterizar o crescimento e absorção de nutrientes pelo tomateiro ‘Debora Victory’ cultivado em sistema orgânico. Os tratamentos constituíram-se por nove épocas de amostragem, aos 2, 32, 46, 60, 77, 91, 109, 122 e 137 dias após o transplante (DAT). As plantas atingiram acúmulo estimado de massa seca e fresca na parte aérea na última amostragem de 550 e 9528 g/planta, respectivamente. Ao final do ciclo, a distribuição da massa seca foi de 73% nos frutos, 16% nas folhas e 11% no caule. A produtividade de frutos frescos totais foi estimada em 154,7 t/ha. A ordem decrescente do acúmulo de nutrientes na parte aérea das plantas foi K>N>Ca>P>S>Mg, com valores estimados de 22,6; 10,4; 5,0; 2,3; 2,1 e 1,6 g/planta, respectivamente, correspondendo a 431; 198; 95; 44; 40 e 30 kg/ha de K, N, Ca, P, S e Mg, respectivamente. A ordem decrescente do acúmulo de nutrientes nos frutos foi K>N>P>S>Mg>Ca, com valores estimados de 16,6; 8,4; 1,7; 0,8; 0,7 e 0,2 g/planta, respectivamente, o que correspondeu a uma extração estimada total de 315; 153; 32; 16; 14 e 3 kg/ha de K, N, P, S, Mg e Ca, respectivamente. Na última amostragem, o maior acúmulo de N, P e K ocorreu nos frutos e de Ca, S e Mg na parte vegetativa (caule + folhas). Debora Victory orgânico constituíramse constituíram se 2 32 46 60 77 91 109 12 13 DAT. DAT . (DAT) 55 952 gplanta g planta g/planta respectivamente ciclo 73 16 11 caule 1547 154 7 154, tha t ha t/ha KNCaPSMg N Ca K>N>Ca>P>S>Mg 22,6 226 22 6 10,4 104 10 4 5,0 50 5 0 2,3 23 21 1 1, 431 198 95 44 kgha kg KNPSMgCa K>N>P>S>Mg>Ca 16,6 166 8,4 84 8 1,7 17 0,8 08 07 0, 02 315 153 folhas. folhas) 9 (DAT 15 22, 10, 5, 43 19 16, 8, 31

ABSTRACT The aim of this study was to characterize the growth and nutrient absorption of ‘Debora Victory’ tomato grown in organic system. The treatments consisted of nine sampling dates, at 2, 32, 46, 60, 77, 91, 109, 122 and 137 days after transplantation (DAT). In the last sampling, plants reached an estimated accumulation of dry and fresh weight in plant shoots of 550 and 9,528 g/plant, respectively. At the end of the cycle, the distribution of dry matter was 73% in the fruits, 16% in the leaves and 11% in the stem. The yield of total fresh fruits was estimated at 154.7 t/ha. The decreasing order of nutrient accumulation in plant shoots was K>N>Ca>P>S>Mg, with estimated values of 22.6; 10.4; 5.0; 2.3; 2.1 and 1.6 g/plant, respectively, corresponding to 431; 198; 95; 44; 40 and 30 kg/ha of K, N, Ca, P, S and Mg, respectively. The decreasing order of nutrient accumulation in the fruits was K>N>P>S>Mg>Ca, with estimated values of 16.6; 8.4; 1.7; 0.8; 0.7 and 0.2 g/plant, respectively, which corresponded to an estimated total extraction of 315; 153; 32; 16; 14 and 3 kg/ha of K, N, P, S, Mg and Ca, respectively. In the last sampling, the greatest accumulation of N, P and K occurred in the fruits and Ca, S and Mg in the vegetative organs (stem + leaves). Debora Victory system dates 2 32 46 60 77 91 109 12 13 DAT. DAT . (DAT) 55 9528 9 528 9,52 gplant g g/plant respectively cycle 73 16 11 stem 1547 154 7 154. tha t ha t/ha KNCaPSMg N Ca K>N>Ca>P>S>Mg 22.6 226 22 6 10.4 104 10 4 5.0 50 5 0 2.3 23 21 1 2. 1. 431 198 95 44 kgha kg KNPSMgCa K>N>P>S>Mg>Ca 16.6 166 8.4 84 8 1.7 17 0.8 08 07 0. 02 315 153 leaves. leaves) (DAT 952 52 9,5 15 22. 10. 5. 43 19 16. 8. 31 9,

https://doi.org/10.1590/s0102-0536-2023-e2532

11.

Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV
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Menezes Filho, Hélio Ranes de

; Grandi, Giuliano Cardoso, Ludimila Paula Vaz Silva, Juan Felipe Galvão da Machado, Soraia Mafra Almeida-Neto, Cesar de Sabino, Ester Cerdeira Mendes-Corrêa, Maria Cássia

Brazilian Journal of Infectious Diseases

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2023, Volume 27 Nº 5 elocation 102810

Resumo: En | Texto: En | PDF: En

ABSTRACT Among individuals coinfected with HCV and HIV, studies of mortality from non-hepatic causes have shown inconsistent results. The aim of this study was to investigate the contribution of HCV and HIV co-infection to mortality from hepatic and non-hepatic causes in Brazil. This retrospective cohort study included blood donors from Fundação Pró-Sangue de São Paulo (FPS) who were followed from 1994 to 2016 to compare mortality and its causes between HIV-HCV coinfected individuals versus those seronegative for all tested infections. Records from the FPS database and the Mortality Information System were linked through a probabilistic record Relationship (RL). The Hazard Ratio (HR) was estimated using Cox multiple regression models. HCV-HIV coinfected individuals compared to seronegative individuals had a higher risk of death from all causes (HR = 14.54), non-liver neoplasms (HR = 2.55), infections (HR = 10.37) and liver disease (HR = 7.0). In addition, HCV mono-infected individuals compared to seronegative individuals had a higher risk of death from all causes (HR = 2.23), liver cancer (HR = 32.21), liver disease (HR = 14.92), infection (HR = 3.22), and trauma (HR = 1.68). Individuals coinfected with HCV and HIV have increased overall mortality and death due to infections, liver diseases and non-liver neoplasms as compared to those uninfected with HCV and HIV.

https://doi.org/10.1016/j.bjid.2023.102810

12.

Pigmented eccrine poroma in an atypical location
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Alfredo, Melissa de Almeida Corrêa

; Lai, Mariana Righetto de Ré

; Miot, Luciane Donida Bartoli

; Haddad, Gabriela Roncada

; Garcia, Aline Lutz

; Miot, Hélio Amante

Anais Brasileiros de Dermatologia

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Out 2022, Volume 97 Nº 5 Páginas 624 - 627

Resumo: En | Texto: En | PDF: En

Abstract Eccrine poroma is the term that includes benign neoplasms of the terminal duct of the eccrine sweat glands, which may clinically and dermoscopically resemble other melanoma and non-melanoma skin tumors. They are often located on the extremities (especially palms and soles), presenting as normochromic or erythematous papules and nodules, measuring up to 2 cm. Pigmented variants are uncommon, accounting for less than 20% of cases. This report describes a 37-year-old man who developed a large pigmented eccrine poroma on his right shoulder, causing diagnostic difficulty. Histopathological examination revealed a nodular neoplasm consisting of small, monomorphic, cuboidal cells, with ample, eosinophilic cytoplasm and well-defined borders, in addition to conspicuous intercellular bridges, with melanin deposits diffusely distributed inside them. The absence of cytological atypia, cellular pleomorphism, increased mitotic activity, and necrosis foci corroborated the diagnostic exclusion of porocarcinoma, which can develop from eccrine poroma.

https://doi.org/10.1016/j.abd.2021.10.006

13.

Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study
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Cristelli, Marina Pontello

; Sandes-Freitas, Tainá Veras de

; Viana, Laila Almeida

; Requião-Moura, Lúcio R.

; Andrade, Luis Gustavo Modelli de

; Tedesco-Silva, Helio

; Medina-Pestana, José

Brazilian Journal of Nephrology

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Set 2022, Volume 44 Nº 3 Páginas 428 - 433

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução: A pandemia da COVID-19 afetou receptores de transplante renal (TR), com taxas de mortalidade mundial em torno de 25%. Considerando as notórias disparidades sócio-demográficas brasileiras, este relatório descreve pela primeira vez principais características e desfechos da doença em receptores de TR, segundo as regiões geográficas. Métodos: Esta análise retrospectiva multicêntrica nacional incluiu dados de receptores de TR com COVID-19 confirmada entre Março/Novembro de 2020. Resultados: Trinta e cinco dos 81 centros (57% da atividade de transplante renal brasileira) relataram 1.680 pacientes com COVID-19. O Nordeste foi o primeiro a atingir o pico no número de infecções. O Sudeste, por sua densidade populacional, contribuiu com maior número de pacientes. Pacientes tinham em média 52 anos, 76% apresentavam hipertensão e 34% diabetes, 75% receptores de doador falecido e o tempo entre diagnóstico e transplante foi de 5,9 anos. Em 53% dos pacientes, os imunossupressores foram ajustados, e o tratamento variou segundo a região. Hospitalização foi necessária para 65% dos pacientes, 35% necessitaram de cuidados intensivos, 25% ventilação mecânica, e 23% terapia renal substitutiva. A mortalidade geral em 90 dias foi 21%, sendo 23% no Sudeste, 16% no Nordeste, e 19% nas regiões Centro-Oeste e Sul. Conclusão: O padrão migratório da pandemia entre os receptores de TR seguiu o da população em geral e os desfechos foram influenciados por características regionais. A COVID-19 em receptores de TR foi associada à alta utilização de recursos de saúde e taxas de mortalidade mais altas do que as relatadas na população em geral.

Abstract Introduction: The unprecedented coronavirus disease 2019 (COVID-19) pandemic has affected kidney transplant (KT) recipients, with worldwide fatality rates around 25%. Considering the well-known Brazilian socio-demographic disparities, this report describes for the first time the main outcomes of COVID-19 in KT recipients according to Brazilian geographic regions. Methods: This multicenter national retrospective analysis included data from KT recipients with confirmed COVID-19 between March and November 2020. Results: Thirty-five of the 81 centers (57% of KT activity in Brazil) reported 1,680 patients with COVID-19. The Northeast was the first to reach the peak in the number of infections. The Southeast, due to its population density, contributed with the largest number of patients. Patients had a median age of 52 years, 76% had hypertension and 34% diabetes, 75% were recipients of a deceased donor, and the time interval between diagnosis and transplantation was 5.9 years. In 53% of patients, immunosuppression was adjusted, and clinical support varied according to geographic region. Hospitalization was required for 65% of the patients, 35% of them needed intensive care, 25% mechanical ventilation, and 23% renal replacement therapy. The 90-day overall fatality was 21%, being 23% in the Southeast, 16% in the Northeast, and 19% in the Central-west and South regions. Conclusion: The migratory pattern of the pandemic among KT recipients followed that of the general population and the outcomes were influenced by regional features. COVID-19 in KT recipients was associated with high utilization of health-care resources and higher fatality rates than those reported in the general population.

https://doi.org/10.1590/2175-8239-jbn-2021-0063

14.

Response of Vaccination Coverage Against COVID-19 in a Group of Maxillofacial Surgeons from Public Service in Northeastern Brazil: A Case Series Study
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Alves da Mota Santana, Lucas dos Santos Costa, Sara Ferreira Andrade Pinho, John Nadson Melo de Alburquerque, Helio Igor Martins Paiva, Saul Mitsunari Takeshita, Wilton do Amaral, Regiane Cristina de Almeida Souza, Liane Maciel

International journal of odontostomatology

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Mar 2022, Volume 16 Nº 1 Páginas 109 - 111

Resumo: En | Texto: En | PDF: En

15.

Factors associated with COVID-19 mortality in municipalities in the state of São Paulo (Brazil): an ecological study
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Souza, Rafaela Caroline de

; Almeida, Ettore Rafael Mai

; Fortaleza, Carlos Magno Castelo Branco

; Miot, Hélio Amante

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 elocation e0447-2021

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: The mortality rate of coronavirus disease (COVID-19) in the state of São Paulo is highly heterogeneous. This study investigated geographic, economic, social, and health-related factors associated with this discrepancy. Methods: An ecological study compared COVID-19 mortality rates according to geographic, economic, social, and health-related variables during initial infection of 2.5% of the population in municipalities with more than 30,000 inhabitants. Results: Mortality was positively associated with demographic density and social inequality (Gini index), and inversely associated with HDI income and longevity of these municipalities, accounting for 33.2% of the variation in mortality. Conclusions: Social determinants influenced COVID-19 outcomes.

https://doi.org/10.1590/0037-8682-0447-2021

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