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Investigating the Inhibitory Mechanism of para-Sulfonato-calix[4]arenes against Polymerase and Helicase of SARS-CoV-2: Molecular Docking and Dynamics Simulation Studies paraSulfonatocalix4arenes paraSulfonatocalixarenes para Sulfonato calix 4 arenes SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV-2 paraSulfonatocalix SARS-CoV- SARS-CoV
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Khan, Khalid

; Rahman, Habib

; Shah, Tanzeel

; Rashid, Haroon ur

; Ahmad, Nasir

; Muhammad, Akhtar

; Umar, Muhammad Naveed

; Gulfam, Naila

; Zahoor, Muhammad Ullah, Riaz Ali, Essam A.

Journal of the Brazilian Chemical Society

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2025, Volume 36 Nº 1 elocation e-20240108

Resumo: En | Texto: En | PDF: En

The coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a profound impact on global health and socio-economic conditions. To date, various vaccines have been administered worldwide in an effort to curb the spread of the virus. Despite vaccination efforts, there have been complications. Existing antiviral drugs have shown limited effectiveness, prompting the use of computational methods to understand the dynamics of the virus and develop suitable treatments. The current study focuses on using biocompatible para-sulfonato-calix[4]arenes to dock against two key proteins of SARS-CoV-2, namely ribonucleic acid (RNA)-dependent RNA polymerase, and helicase. Docking results indicate a strong binding affinity of these compounds to the target proteins, with higher scores compared to commonly used medications. Molecular dynamics (MD) simulation validates the docking results, showing stable protein-ligand complexes over time. The compounds are also screened for absorption, distribution, metabolism, and excretion properties and toxicity, suggesting their potential as lead candidates for inhibiting the virus’s key proteins. However, further in vivo and in vitro studies are recommended to confirm these findings. COVID19 COVID 19 (COVID-19 pandemic SARSCoV2, SARSCoV2 SARSCoV SARS CoV , (SARS-CoV-2) socioeconomic socio economic conditions date efforts complications effectiveness treatments parasulfonatocalix4arenes parasulfonatocalixarenes para sulfonato calix 4 arenes 2, SARS-CoV-2 RNAdependent dependent polymerase helicase medications MD (MD proteinligand protein ligand time absorption distribution metabolism toxicity viruss s However findings COVID1 1 (COVID-1 (SARS-CoV-2 parasulfonatocalix SARS-CoV- (COVID- (SARS-CoV- SARS-CoV (COVID (SARS-CoV

https://doi.org/10.21577/0103-5053.20240108

FAITH AS VIRTUE: THE NECESSITY OF DOUBT VIRTUE
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Alhayyani, Mesfer

; Sharaf, Ali

Perspectiva Teológica

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Dez 2024, Volume 56 Nº 3 Páginas 657 - 672

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este artigo centra-se no papel desempenhado pela dúvida na formação da fé enquanto estado mental dos seres humanos. Nos debates contemporâneos sobre a fé, a dúvida refuta uma teoria ou apoia outra. No entanto, a questão crucial mantém-se: será a dúvida um elemento essencial inerente à fé? Este artigo defende que a dúvida é uma componente fundamental e necessária da fé, especialmente quando se considera a fé como uma virtude. A primeira parte deste artigo estabelece o enquadramento para este estudo, abordando algumas questões cruciais relevantes, tais como: quais são os aspectos necessários da fé. A fé é uma virtude? A segunda parte defende que, tendo em conta a descrição da fé desenvolvida na primeira parte do estudo, a dúvida é um elemento e uma componente necessários da fé para que esta possa ser considerada uma virtude. A metodologia deste estudo baseia-se na análise crítica de fontes primárias e secundárias relevantes para a fé como virtude e na realização de análises conceptuais e argumentativas. centrase centra humanos outra entanto mantémse mantém mantém-se baseiase baseia argumentativas

Abstract This paper focuses on the role played by doubt in shaping faith as a mental state in humans. In contemporary discussions on faith, doubt refutes a theory or supports another. However, the crucial question remains: is doubt an essential element inherent in faith? This paper argues that doubt is a fundamental and necessary component of faith, especially when considering faith as a virtue. The first part of this paper sets the framework for this study by addressing some crucial relevant questions, such as what the necessary aspects of faith are. Is faith a virtue? The second part argues that, given the account of faith developed in the first part of the study, doubt is a necessary element and component of faith for it to be considered a virtue. This study’s methodology is founded on critically examining primary and secondary sources relevant to faith as a virtue and engaging in conceptual and argumentative analyses. humans another However remains questions are studys s analyses

https://doi.org/10.20911/21768757v56n3p657/2024

Obesity is South Africa's new HIV epidemic
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Chandiwana, Nomathemba Venter, W D Francois Manne-Goehler, Jennifer M Wade, Alisha le Roux, Carel W Mbalati, Nzama Lawrence Grimbeek, Angelika Kruger, Petronell Montsho, Eunice Zimela, Zukiswa Yawa, Anele Tshabalala, Sibongile Rambau, Ndivhuwo Mpofu, Ngqabutho Stevenson, Sasha McNulty, Bridget Ntusi, Ntobeko A B Pillay, Yogan Dave, Joel A Murphy, Angela Goldstein, Sue Hofman, Karen Mahomedy, Sameera Thomas, Elizabeth Mrara, Busi Wing, Jeff Lubbe, Jeanne Koto, Zack Conradie-Smit, Marli Wharton, Sean May, Wayne Marr, Ian Kaplan, Hilton Forgan, Mariam Alexander, Graham Turner, J S Fourie, V R Ann Hellig, Jocelyn Banks, Mandy Ragsdale, K E Noeth, M Mohamed, Farzahna Myer, Landon Lebina, Limakatso Maswime, Salome Moosa, Yunus Thomas, Teressa Sumy Mbelle, Mzamo Sinxadi, Phumla Bekker, Linda-Gail Bhana, Sindeep Fabian, June Decloedt, Eric Bayat, Zaheer Daya, Reyna Bobat, Bilal Storie, Fiona Goedecke, Julia H Kahn, Kathleen Tollman, Stephen Mansfield, Brett Siedner, Mark J Marconi, Vincent C Mody, Aaloke Mtshali, Ntombifikile Nokwethemba Geng, Elvin Srinivasa, Suman Ali, Mohammed K Lalla-Edward, Samanta Bentley, Alison Wolvaardt, Gustaaf Hill, Andrew Nel, Jeremy

SAMJ: South African Medical Journal

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Mar 2024, Volume 114 Nº 3 Páginas 1 - 4

Resumo: En | Texto: En | PDF: En

https://doi.org/10.7196/SAMJ.2024.v114i3.1927

Vaccination against Rhipicephalusmicroplus: an alternative to chemical control?
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Silva, Lucas Andre Dedavid e

; Ali, Abid

; Termignoni, Carlos

; Vaz Júnior, Itabajara da Silva

Ciência Rural

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2024, Volume 54 Nº 3 elocation e20230161

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT: Rhipicephalus (Boophilus) microplus is a hard tick endemic in livestock-growing regions and causes economic losses in the largest beef-producing countries, including Brazil, Mexico, Argentina, Australia and Uruguay. The use of chemical acaricides is still the main strategy to control R. microplusinfestations. Nevertheless, immunological control of R. microplus with an anti-tick vaccine is a suitable alternative and has manifold advantages because it can avoid drug-resistance and the presence of acaricide residues in milk, beef and in the environment. Indeed, vaccines based on the Bm86 antigen have had relative commercial and technical success to control R. microplus in some regions. Although, the efficacy of such vaccines varies among tick populations and is insufficient to provide an acceptable level of protection. Therefore, the need to search for better antigens is impelling. This review focused on the restrictions imposed on the use of acaricides in Brazil and in the European Union, as well as on the impacts of Bm86-based vaccines on R. microplus control. The efficacy of experimental anti-tick vaccines (based on subolesin, glutathione S-transferase, ferritin 2; voltage-dependent anion channel; aquaporin, 60 S acidic ribosomal protein, metalloprotease and trypsin) that can elicit an immune response against the physiological functions of various ticks is discussed.

RESUMO: O Rhipicephalus (Boophilus) microplus é um carrapato duro que é endêmico de regiões de pecuária e causa perdas econômicas nos maiores países produtores de carne bovina, incluindo Brasil, México, Argentina, Austrália e Uruguai. O uso de acaricidas ainda é a principal estratégia para controlar infestações por R. microplus. No entanto, o controle imunológico do R. microplus com uma vacina contra carrapatos é uma alternativa adequada e possui diversas vantagens, por evitar a seleção de populações de carrapato resistentes a drogas, evitar a presença de resíduos de acaricidas no leite, na carne e no ambiente. As vacinas baseadas no antígeno Bm86 tiveram relativo sucesso comercial e técnico no controle do R. microplus em diversas regiões. No entanto, a eficácia dessas vacinas varia entre as populações de carrapatos e é insuficiente para fornecer um nível aceitável de proteção. Portanto, há uma necessidade de procurar novos antígenos. Esta revisão foca nas restrições impostas ao uso de acaricidas no Brasil e na União Europeia, bem como nos impactos das vacinas baseadas em Bm86 no controle do R. microplus. Também é discutida a eficácia de vacinas anti-carrapatos experimentais (baseadas em subolesina, glutationa S-transferase, ferritina 2; canal aniônico dependente de voltagem; aquaporina, proteína ribossômica ácida 60S, metaloprotease, tripsina) que podem elicitar uma resposta imune contra as funções fisiológicas de vários carrapatos.

https://doi.org/10.1590/0103-8478cr20230161

Effect of Blend of Essential Oils on Growth Performance, Carcass Characteristics, Meat Quality, Intestinal Morphology, Serum Biochemistry, and Immune Response of Broiler Chickens Performance Characteristics Quality Morphology Biochemistry
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Khan, MT

; Rehman, MF

; Arslan, M

; Javaid, A

; Farooq, U

; Asad, T

; Nisa, Q

; Azhar, M

; Bughio, E

; Liaqat, S

; Aslam, S

; Ali, F

; Ali, H

; Wadood, F

; Gondal, MA

; Rauf, M

; Fouad, D

; Ataya, FS

; Safdar, M

; Nazir, S

; Magsi, AS

; Qumar, M

Brazilian Journal of Poultry Science

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2024, Volume 26 Nº 1 elocation eRBCA-2023-1853

Resumo: En | Texto: En | PDF: En

ABSTRACT The purpose of this study was to assess the impact of a blend of essential oils from eucalyptus, citrus, bromohexene HCl, thymole and camphor on the growth performance, carcass characteristics, meat quality, intestinal morphology, serum biochemistry, and immune response of broiler chickens. A total of 240 day-old chicks were divided into four groups, each with six replicates containing ten birds. The experiment was conducted under a completely randomized design (CRD). Different concentrations of the oil blend (0mL/kg, 0.15mL/kg, 0.30mL/kg and 0.45mL/kg) were added to the diet. The findings showed that, in comparison to the other groups, the birds that were given a blend of essential oils at concentrations of 0.30 and 0.45 mL/kg showed improved weight gain, feed efficiency, carcass yield, villus height, crypt depth, and greater immune response against Newcastle disease vaccination (p<0.05). Nonetheless, there was no statistically significant difference in the yields of the breast and thighs, feed consumption, mortality, weights of the liver, wing, heart, and gizzard, or abdominal fat between the treatments. The addition of a blend of essential oils at the doses of 0.30 and 0.45 mL/kg significantly lowered the pH of the meat in comparison to the other groups (p<0.05). All blood biochemical markers, including total serum protein, albumin, globulin, glucose, cholesterol, triglyceride, and uric acid, revealed no variations between the treatments. In conclusion, adding 0.30mL/kg of a blend of essential oils to broiler diets may be the optimum level to improve overall performance without adversely affecting the blood biochemical profile. eucalyptus citrus HCl characteristics quality morphology biochemistry chickens 24 dayold day old CRD. CRD . (CRD) 0mL/kg, 0mLkg mLkg 0mL kg mL (0mL/kg 015mLkg 0 15mL 0.15mL/kg 030mLkg 30mL 0.45mL/kg 045mLkg 45mL diet 030 30 0.3 045 45 0.4 gain efficiency yield height depth p<0.05. p005 p p<0.05 05 (p<0.05) Nonetheless thighs consumption mortality liver wing heart gizzard treatments markers protein albumin globulin glucose cholesterol triglyceride acid conclusion profile 2 (CRD 0mL/kg 03 3 0. 04 4 p00 p<0.0 (p<0.05 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

https://doi.org/10.1590/1806-9061-2023-1853

Comparison of labetalol and lidocaine in induction of controlled hypotension in tympanoplasty: a randomized clinical trial tympanoplasty
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Karami, Ali

; Saravi, Zeinabsadat Fattahi

; Hosseini, Hossein

; Rahmati, Mehdi

; Jahangiri, Reza

; Asmarian, Naeimehossadat

; Banifatemi, Mahsa

Brazilian Journal of Otorhinolaryngology

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2024, Volume 90 Nº 3 elocation 101403

Resumo: En | Texto: En | PDF: En

Abstract Objectives This study aimed to compare the efficacy of labetalol and lidocaine in tympanoplasty surgery, specifically evaluating their impact on hemodynamic changes and perioperative outcomes. Methods A randomized controlled trial was conducted with 64 patients scheduled for tympanoplasty. Patients were randomly assigned to receive either 0.5-2 mg/min labetalol or 1.5 mg/kg/h lidocaine 1% to achieve controlled hypotension during surgery. The efficacy of the drugs was assessed by comparing the Mean Arterial Pressure (MAP), surgeon's satisfaction, time to target MAP, bleeding volume, postoperative pain scores, the need for analgesic medication in recovery, sedation, and other additional parameters. Results The hemodynamic parameters showed a similar trend over time in both the labetalol and lidocaine groups. The median bleeding volume in the labetalol group (10 cc) was lower than that in the lidocaine group (30 cc), although this difference was not statistically significant (p= 0.11). Similarly, surgeon's satisfaction level, pain intensity, and sedation level in the recovery room did not show statistically significant differences between the two groups (p> 0.05). The duration of surgery, recovery stay, and extubation time also did not significantly differ between the groups. Both medications took approximately the same time (20 min) to reach the target MAP and exhibited comparable hemodynamic responses (p> 0.05). Conclusion Both labetalol and lidocaine effectively achieved controlled hypotension during tympanoplasty surgery, thereby improving surgical conditions. The choice of medication should be based on individual patient characteristics and the anesthesiologist's judgment. Level of evidence: II. surgery outcomes 6 0.52 052 0.5 2 0 5 0.5- mgmin mg min 15 1 1. mgkgh kg h , (MAP) surgeons surgeon s scores 10 (1 cc 30 (3 cc, p= p (p 0.11. 011 0.11 . 11 0.11) Similarly intensity p> 0.05. 005 0.05 05 0.05) stay 20 (2 conditions anesthesiologists anesthesiologist judgment evidence II 52 0. (MAP ( 3 01 0.1 00 0.0

https://doi.org/10.1016/j.bjorl.2024.101403

Examining the Stomach Structure and Function in Mudskipper (Periophthalmus waltoni) by Histological and Immunohistochemical Methods Periophthalmus waltoni
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Wilson, Jonathan Mark

; Farahani, Mina Amiri

; Esfandiyari, Kaveh

; Babaei, Mohammad

; Kalantari-Hesari, Ali

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24230884

Resumo: En | Texto: En | PDF: En

Abstract Anatomically, the digestive system of oxudercinae lacks a distinct stomach, and that is why this group of fish is classified as stomachless. Since the environment, dietary requirements, and eating habits strongly influence the anatomy of the fish's digestive system, mudskippers (Periophthalmus waltoni) appear to have a stomach due to their carnivorous nature. The present study was undertaken to confirm the presence of stomach in P. waltoni and for this purpose, histological and immunohistochemical methods were used in this study. The results of this study showed that despite absence of an anatomical and distinct stomach, histological point of view the digestive system of this species was divided into 4 distinct parts; esophagus, stomach, intestine, and rectum. The stomach consisted of tubular glands in which the oxynticopeptic cells were present. In an immunohistochemical examination, the observation of the protein channels H+/K+ ATPase and Na+/K+/Cl cotransporter in the membrane of the oxynticopeptic cells confirmed the function of the stomach. In conclusion, the digestive system of P. waltoni is consist of the esophagus, stomach, intestines, and rectum, anatomically. Microscopic evaluation of digestive system indicated that unlike some other species, the Stomach is existed in P. waltoni, but has not any secretion of acid. Anatomically stomachless environment requirements fishs s Periophthalmus nature P purpose parts esophagus intestine rectum examination HK H K H+/K NaKCl Na Cl conclusion intestines anatomically acid

https://doi.org/10.1590/1678-4324-2024230884

Investigation the Effect of TiC on Some Properties of ZA-27 Alloy Prepared By Powder Metallurgy Method ZA27 ZA 27 ZA-2 ZA2 2 ZA-
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Eqal, Asaad Kadhim

; Yagoob, Jawdat Ali

; Hussein, Haidar Akram

Materials Research

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2024, Volume 27 elocation e20240143

Resumo: En | Texto: En | PDF: En

The existing work is dedicated toward the manufacture of ZA-27/TiC as composites material via powder metallurgy. A mixture of Zn and Al with 63 and 27 wt%, respectively, is ball milled for 4 hrs at 145 rpm. Then, samples with disk-like shapes were made through pressing under 600 MPa and afterward sintered at 336 °C for 90 minutes in an electric furnace in argon gas. Other three groups from the above Zn and Al mixture ratio were prepared but with the addition of 3, 6, and 9 wt% TiC particles independently. The group's samples were prepared at the same conditions above. Hardness, density, and porosity microstructure observations, including optical and SEM-Mapping techniques were utilized to validate the effect of TiC particle additions with the listed above contents on the prepared ZA-27 alloy properties. The practical density of the prepared ZA-27 alloy is decreased basically owing to the used powder metallurgy route and with a lesser degree due to TiC addition. In contrast, the porosity is increased. But the hardness of the ZA-27 alloy is improved when TiC was added, and it was increased from 49.4 to 66 VHN with 0 to 9 wt% TiC addition. The optical microscope and SENM-Mapping facilities explained the distribution of co-existing Zn, Al, and TiC particles in the microstructures of the tested samples to improve the properties of ZA alloy. ZA27/TiC ZA27TiC ZATiC 27/TiC 6 2 wt respectively 14 rpm Then disklike disk like 60 33 C gas 3 independently group s Hardness observations SEMMapping SEM Mapping ZA27 ZA-2 contrast added 494 49 49. SENMMapping SENM coexisting co 27TiC 1 ZA2 ZA-

https://doi.org/10.1590/1980-5373-mr-2024-0143

Growth performance and nutrient digestibility of broilers fed low-energy corn-soybean meal-based diets supplemented with an exogenous enzyme cocktail as a combined activity lowenergy low energy cornsoybean corn soybean mealbased meal based
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Alqhtani, Abdulmohsen H.

; Al Sulaiman, Ali R.

; Alharthi, Abdulrahman S.

; Abudabos, Ala E.

Revista Brasileira de Zootecnia

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2024, Volume 53 elocation e20230100

Resumo: En | Texto: En | PDF: En

ABSTRACT The experiment aimed to evaluate the effects of supplementing a standard broiler diet, formulated based on corn and soybean meal (CSBM), with two levels of an exogenous enzyme (EZ) cocktail (0 and 0.05%), under two dietary metabolizable energy (ME) levels – normal (positive control, PC) and low (negative control, NC). From 0 to 35 d, 288 Ross 308 chicks were distributed across four treatments with 12 replicates of six chicks each. Growth performance was evaluated during the starter, grower, finisher, and cumulative period. At 35 d, blood samples were collected to measure serum metabolite concentrations, and birds were processed to determine carcass traits. Ileum segments were prepared for histological measurements, and excreta were collected to analyze apparent nutrient digestibility. Data were analyzed employing two-way ANOVA and Tukey’s test. The results indicated no significant interaction between ME and EZ for any measured parameter. The EZ supplementation improved feed conversion rate (FCR) during the starter phase, and improved feed intake, body weight gain (BWG), FCR, and production efficiency index (PEI) during the grower phase; PEI during the finisher phase; and BWG, FCR, PEI, and final BW over the cumulative phase. Furthermore, EZ enhanced dressing percentage, breast yield, villi length, retention of crude protein, and nitrogen-corrected ME (AMEn), while also increasing glucose concentration and reducing the relative weight of the gizzard and intestine. Compared with the NC diet, the PC diet enhanced feed efficiency across the grower, finisher, and cumulative phases and increased AMEn and triglyceride levels. Supplementing ME-adequate CSBM diets with an EZ cocktail can boost the nutrient digestibility and growth efficiency of broilers. CSBM, , (CSBM) (EZ ( 0.05%, 005 0.05% 05 0.05%) (ME positive control negative NC. . NC) 3 d 28 30 1 each period concentrations traits measurements twoway way Tukeys Tukey s test parameter FCR (FCR phase intake BWG (BWG) (PEI Furthermore percentage yield length protein nitrogencorrected nitrogen corrected AMEn, (AMEn) intestine MEadequate adequate broilers (CSBM 00 0.05 2 (BWG (AMEn 0.0 0.

https://doi.org/10.37496/rbz5320230100

10.

Test of Oral Health Literacy in Adults (TOHLA): development and psychometric evaluation of a new scale TOHLA (TOHLA) (TOHLA
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GHAFFARI, Mohtasham

; RAKHSHANDEROU, Sakineh

; MIALHE, Fábio Luiz

; MEHRABI, Yadollah

; SAFARI-MORADABADI, Ali

Brazilian Oral Research

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2024, Volume 38 elocation e059

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to develop and rigorously evaluate the Test of Oral Health Literacy in Adults (TOHLA) for the Iranian population, addressing the limitations of existing oral health literacy (OHL) measurement instruments and contributing to the literature on OHL assessment. The development of the TOHLA involved a qualitative approach, which included a comprehensive literature review and semi-structured interviews with a panel of 15 experts from diverse fields and 22 Iranian adults aged 18 to 64 years. The instrument was designed with 48 items categorized into four domains: cognitive skill, communication skill, media skill, and functional skill. Content validity was established through expert input and content validation indices. Construct validity was supported by factor analysis, and concurrent validity was assessed by comparing TOHLA scores with demographic variables. Internal consistency and test-retest reliability analyses were performed to assess the instrument’s reliability. The psychometric evaluation of the TOHLA demonstrated strong content validity, construct validity, concurrent validity, internal consistency, and test-retest reliability. The instrument exhibited a high level of internal consistency, with a Cronbach’s alpha coefficient of 0.81 for the entire scale. Test-retest reliability was satisfactory, with an intraclass correlation coefficient (ICC) of 0.83. Concurrent validity analysis showed statistically significant associations between OHL scores and demographic variables, supporting the instrument’s overall performance. The TOHLA overcomes the weaknesses observed in existing instruments and offers a comprehensive tool with strong psychometric properties to assess the OHL of the Iranian adult population. Researchers, policymakers, and healthcare providers can utilize the TOHLA to address oral health challenges and enhance overall oral health outcomes among Iranian adults. (TOHLA population (OHL assessment approach semistructured semi structured 1 2 6 years 4 domains skill indices variables testretest test retest s Cronbachs Cronbach 081 0 81 0.8 scale Testretest satisfactory ICC (ICC 083 83 0.83 performance Researchers policymakers 08 8 0.

https://doi.org/10.1590/1807-3107bor-2024.vol38.0059

11.

The Lack of High-quality Educational Resources about Adhesive Capsulitis on YouTube Highquality High quality
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Yüce, Ali

; Gür, Volkan

; Yerli, Mustafa

; Misir, Abdulhamit

Revista Brasileira de Ortopedia

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2024, Volume 59 Nº 2 Páginas 260 - 268

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Objective The advent of the Internet has provided new, easily accessible resources for patients seeking additional health information. Many doctors and healthcare organizations post informative videos on this platform, and nearly all patients are looking for videos online for a second opinion. Methods The phrases "frozen shoulder," "frozen shoulder treatment," "adhesive" capsulitis, and "adhesive capsulitis treatment" were entered into YouTube's search bar for a normal inquiry. The informativeness and overall quality of the adhesive capsulitis videos were rated using three separate scales. Results The mean and standard deviation values of the scoring systems were JAMA 1.25 ± 0.51, DISCERN 39.4 ± 13.4, GQS 2.83 ± 0.96 and ACSS 7.43 ± 4.86, respectively. Number of views, rate of views, and likes all had a positive correlation with Global Quality Score (GQS), as did DISCERN and ACSS. There was no statistically significant difference between the median JAMA, GQS score and Discern Criteria values according to the video source/uploader (p > 0.05). Conclusion YouTube videos on adhesive capsulitis, thus, need to be of higher quality, reliability, and instructive quality. There is a need for reliable videos about adhesive capsulitis, with instructional and high-quality cited. new information platform opinion frozen shoulder, treatment, treatment YouTubes s inquiry scales 125 1 25 1.2 051 0 51 0.51 394 39 4 39. 134 13 13.4 283 2 83 2.8 096 96 0.9 743 7 43 7.4 486 86 4.86 respectively views GQS, , (GQS) sourceuploader source uploader p 0.05. 005 0.05 . 05 0.05) thus reliability highquality high cited 12 1. 5 0.5 3 13. 28 8 2. 09 9 0. 74 7. 48 4.8 (GQS 00 0.0 4.

Resumo Objetivo O advento da Internet proporcionou recursos novos e de fácil acesso para pacientes que procuram mais informações sobre saúde. Muitos médicos e organizações de saúde publicam vídeos informativos nesta plataforma e quase todos os pacientes procuram tais vídeos online para uma segunda opinião. Métodos As frases “frozen shoulder (ombro congelado)”, “frozen shoulder treatment (tratamento de ombro congelado)”, “adhesive capsulitis (capsulite adesiva)” e “adhesive capsulitis treatment (tratamento de capsulite adesiva)” foram inseridas na barra de pesquisa do YouTube para uma consulta normal. A informatividade e a qualidade geral dos vídeos sobre capsulite adesiva foram avaliadas usando três escalas distintas. Resultados Os valores de média e desvio padrão dos sistemas de pontuação do Journal of the American Medical Association (JAMA) foram 1,25 ± 0,51, DISCERN, 39,4 ± 13,4, Global Quality Score (GQS, Índice de Qualidade Global em português) 2,83 ± 0,96 e Adhesive Capsulitis Specific Score (ACSS, Escore Específico de Capsulite Adesiva em português), 7,43 ± 4,86, respectivamente. O número de visualizações, a taxa de visualizações e as curtidas tiveram uma correlação positiva com GQS, DISCERN e ACSS. Não houve diferença estatisticamente significativa entre os valores medianos de JAMA, GQS e DISCERN de acordo com a fonte/carregador do vídeo (p > 0,05). Conclusão Os vídeos do YouTube sobre capsulite adesiva precisam ter maior qualidade, confiabilidade e qualidade instrutiva. Há necessidade de vídeos confiáveis sobre capsulite adesiva, com citações instrutivas e de alta qualidade. opinião frozen congelado, congelado , congelado)” tratamento adhesive adesiva) normal distintas JAMA (JAMA 125 1 25 1,2 051 0 51 0,51 394 39 4 39, 134 13 13,4 (GQS português 283 2 83 2,8 096 96 0,9 ACSS, ACSS (ACSS português, 743 7 43 7,4 486 86 4,86 respectivamente fontecarregador fonte carregador p 0,05. 005 0,05 . 05 0,05) instrutiva congelado) 12 1, 5 0,5 3 13, 28 8 2, 09 9 0, 74 7, 48 4,8 00 0,0 4,

https://doi.org/10.1055/s-0044-1785465

12.

Adaptação transcultural para o Português Brasileiro do Perfil de Qualidade de Vida relacionado a Voz
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Carrer, Joyra da Silva

; Zambon, Fabiana

; Dehqan, Ali

; Ribeiro, Vanessa Veis

; Behlau, Mara

CoDAS

Métricas do periódico
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2024, Volume 36 Nº 3 elocation e20230023

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Purpose To cross-culturally adapt the Voice Quality of Life Profile (IVQLP) into Brazilian Portuguese (BP). Methods The cross-cultural adaptation process was performed in five stages: translation of the IVQLP into BP by three native BP experts fluent in American English; preparation of a consensus version; back-translation by a native American English expert fluent in BP; analysis by a committee of five experts and preparation of the final version of the instrument in BP, which was named IVQLP-Br; and pre-testing. The IVQLP-Br aims to assess the impacts of the voice more comprehensively, encompassing various areas of an individual’s life. It has 43 items and a five-level response key. For the pre-test, the alternative “not applicable” was added as a response option. Thirty-six adults with self-reported risk of dysphonia participated in the pre-test. Results In the translation stage, ten items were modified, and during the back-translation, 15 items required adjustments. No questions required reformulation after the application of the IVQLP-Br in the target population, because the option “not applicable” appeared in 12 responses without statistical significance. Conclusion The version of the IVQLP translated into BP, named the IVQLP-Br, exhibited cross-cultural equivalence and was administrable for a more detailed analysis of the impact of the voice in different domains of an individual’s life. After validation, the IVQLP-Br will be able to contribute both to clinical practice and to research with BP speakers. crossculturally cross culturally (IVQLP BP. . (BP) crosscultural cultural stages backtranslation back IVQLPBr Br pretesting. pretesting pre testing. testing pre-testing comprehensively individuals individual s life 4 fivelevel level key pretest, pretest test, test pre-test not applicable Thirtysix Thirty six selfreported self reported pretest. test. stage modified backtranslation, translation, 1 adjustments population significance IVQLPBr, Br, validation speakers (BP

RESUMO Objetivo Traduzir e adaptar de forma transcultural o Iranian Voice Quality of Life Profile (IVQLP) para o português brasileiro (PB). Método O processo de adaptação transcultural foi realizado por meio de cinco etapas: tradução do IVQLP para o PB por três especialistas nativos do PB e fluentes no inglês americano; elaboração de uma versão de consenso; retrotradução por um especialista nativo do inglês americano e fluente no PB; análise por um comitê de cinco especialistas e elaboração da versão final do instrumento em PB, denominado IVQLP-Br; e pré-teste. O IVQLP-Br tem o objetivo de avaliar os impactos da voz de uma forma mais abrangente, englobando vários domínios da vida dos indivíduos, apresenta 43 itens e uma chave de respostas de cinco pontos. Para o pré-teste foi acrescida como opção para o respondente a alternativa “não aplicável”. Participaram do pré-teste 36 indivíduos adultos com risco autorrelatado para disfonia. Resultados Na etapa de tradução 10 itens foram modificados e na retrotradução, 15 itens necessitaram de ajustes. Nenhum item precisou ser reformulado após a aplicação na população-alvo, pois a opção “não aplicável” apareceu em doze respostas, porém, sem significância estatística. Conclusão Conclui-se que a versão traduzida do IVQLP para o PB, denominado IVQLP-Br, apresentou equivalência transcultural e pode ser utilizada para uma análise mais detalhada do impacto da voz nos diferentes domínios da vida dos indivíduos. Após a validação, o IVQLP-Br poderá contribuir tanto para a prática clínica, quanto para pesquisas com falantes do PB. (IVQLP . (PB) etapas consenso IVQLPBr Br préteste. préteste pré teste. teste abrangente 4 pontos não aplicável. aplicável 3 disfonia 1 ajustes populaçãoalvo, populaçãoalvo população alvo, alvo população-alvo porém estatística Concluise Conclui se IVQLPBr, Br, validação clínica (PB

https://doi.org/10.1590/2317-1782/20232023023pt

13.

Zeolite abrogates cadmium-induced testicular damage in rats: implication of NF-κB/ TNF-α/IL-1β Pathway cadmiuminduced cadmium induced rats NFκB/ NFκB NF κB/ κB NF-κB TNFα/IL1β TNFαIL1β TNFαILβ TNF α/IL 1β α IL β TNFα IL1β TNFαIL αIL ILβ
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Ibrahim, N.M.

; Kandil, A.M.

; Ali, R.S.

; Hesham, R.

; El-Ashram, S.

; Alquraishi, M.I.

; Abdel-Gaber, R.

; Dkhil, M.A.

; Elhemiely, A.A.

Arquivo Brasileiro de Medicina Veterinária e Zootecnia

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2024, Volume 76 Nº 4 elocation e13194

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O cádmio (Cd) é um poluente ambiental que afeta vários tecidos e órgãos, inclusive o testículo. Muitos estudos demonstraram que a toxicidade do Cd causa comprometimento testicular por meio de estresse oxidativo e ação inflamatória. Portanto, este estudo teve como objetivo demonstrar a toxicidade testicular do Cd e a ação protetora da zeólita contra os efeitos deletérios do cádmio. Ratos machos adultos receberam Cd em uma dose de 30mg/kg/dia por 28 dias consecutivos com ou sem zeólita, que foi administrada em uma dose de 100mg/kg/dia por 28 dias. Foram avaliados o peso dos testículos, os espermatozoides (contagem, motilidade e anormalidades), a testosterona sérica e o hormônio luteinizante (LH), as enzimas testiculares fosfatase ácida (ACP) e fosfatase alcalina (ALP), as citocinas inflamatórias fator de necrose tumoral alfa (TNF-α), interleucina-1beta (IL-1β) e fator nuclear Kappa B (NF-κB) e estresse oxidativo. Aqui, descobrimos que o cádmio causou alterações nas características dos espermatozoides, distúrbios nos hormônios sexuais, declínio nas enzimas testiculares, conteúdo elevado de malondialdeído (MDA), diminuição da glutationa (GSH), aumento do fator nuclear Kappa B (NF-κB) e níveis de citocinas pró-inflamatórias do fator de necrose tumoral alfa (TNF-α) e interleucina-1beta (IL-1β) no homogenato do testículo. Em contraste, a zeólita alterou significativamente esses efeitos deletérios, e o mecanismo em potencial envolveu a regulação negativa do Fator Nuclear Kappa B (NF-κB), do Fator de Necrose Tumoral Alfa (TNF-α) e da interleucina-1beta (IL-1β), restaurando a glutationa (GSH) e reduzindo o malondialdeído (MDA). Além disso, a zeólita foi associada a uma maior taxa de gravidez. Nossos dados sugerem que o estresse oxidativo e a inflamação são responsáveis pela lesão testicular induzida por Cd e que a administração conjunta de zeólita exerce um efeito protetor por meio da via NF-κB /TNF-α/IL-1β. (Cd órgãos testículo inflamatória Portanto 30mgkgdia mgkgdia 30mg kg dia mg 2 100mgkgdia 100mg testículos contagem, contagem (contagem anormalidades, anormalidades , anormalidades) LH, LH (LH) ACP (ACP ALP, ALP (ALP) TNFα, TNFα TNF α interleucina1beta interleucinabeta interleucina 1beta beta IL1β ILβ IL 1β β (IL-1β NFκB NF κB (NF-κB Aqui sexuais MDA, MDA (MDA) GSH, GSH próinflamatórias pró (TNF-α contraste NFκB, IL1β, (GSH MDA. . disso gravidez /TNFα/IL1β. TNFαIL1β TNFαILβ /TNF α/IL 1β. /TNF-α/IL-1β (LH (ALP (MDA /TNFα/IL1β TNFαIL αIL

ABSTRACT Cadmium (Cd) is an environmental pollutant affecting various tissues and organs, including the testis. Many studies demonstrated that Cd toxicity causes testicular impairment through oxidative stress and inflammatory action. Therefore, this study aimed to demonstrate Cd's testicular toxicity and the protective action of zeolite against cadmium's deleterious effects. Adult male rats were given Cd at a dose of 30mg/kg/day for 28 consecutive days with or without zeolite, which was given at a dose of 100mg/kg/day for 28 days. Testis weight, sperm (count, motility, and abnormalities), serum testosterone and luteinizing hormone (LH), testicular enzymes Acid phosphatase (ACP) and Alkaline phosphatase(ALP), inflammatory cytokines Tumor Necrosis Factor Alpha (TNF-α) , interleukin-1beta (IL-1β) , and Nuclear Factor Kappa B (NF-κB) and oxidative stress were evaluated. Herein, we found that cadmium caused alterations in sperm characteristics, sex hormone disturbance, decline in testicular enzymes, elevated malondialdehyde (MDA) contents, decreased glutathione (GSH), increased Nuclear Factor Kappa B (NF-κB) and pro-inflammatory cytokines Tumor Necrosis Factor Alpha (TNF-α) and interleukin-1beta (IL-1β) levels in testis homogenate. In contrast, zeolite significantly amended these deleterious effects, and the potential mechanism involved the downregulation of Nuclear Factor Kappa B (NF-κB), Tumor Necrosis Factor Alpha (TNF-α) and interleukin-1beta (IL-1β), restoring glutathione (GSH) and reducing malondialdehyde (MDA). Also, zeolite was associated with an increased rate of pregnancy. Our data suggested that oxidative stress and inflammation are responsible for Cd-induced testicular injury and co-administration of zeolite exerts a protective effect via NF-κB /TNF-α/IL-1β pathway. (Cd organs Therefore Cds s cadmiums effects 30mgkgday mgkgday 30mg kg day mg 2 100mgkgday 100mg weight count, count (count motility abnormalities, abnormalities abnormalities) LH, LH (LH) ACP (ACP phosphataseALP, phosphataseALP ALP phosphatase(ALP) TNFα TNF α (TNF-α interleukin1beta interleukinbeta interleukin 1beta beta IL1β ILβ IL 1β β (IL-1β NFκB NF κB (NF-κB evaluated Herein characteristics disturbance MDA (MDA contents GSH, GSH proinflammatory pro homogenate contrast NFκB, IL1β, (GSH MDA. . Also pregnancy Cdinduced induced coadministration co administration /TNFα/IL1β TNFαIL1β TNFαILβ /TNF α/IL pathway (LH phosphatase(ALP TNFαIL αIL

https://doi.org/10.1590/1678-4162-13194

14.

Emerging infection: streptococcal toxic shock-like syndrome caused by group B Streptococcus (GBS), Streptococcus agalactiae infection shocklike shock like GBS, GBS , (GBS) (GBS
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Rajack, Fareed

; Medford, Shawn

; Ramadan, Ali

; Naab, Tammey

Autopsy and Case Reports

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2024, Volume 14 elocation e2024497

Resumo: En | Texto: En | PDF: En

ABSTRACT Streptococcus agalactiae or Group B Streptococcus (GBS) infections are commonly associated with infections in neonates and pregnant women. However, there has been a rising incidence in nonpregnant adults. The risk of GBS infection in nonpregnant adults is increased for patients of advanced age and those with underlying medical conditions such as diabetes mellitus and cancer. We present a 77-year-old female with type-2 diabetes mellitus, hypertension, and bilateral foot ulcers that presented in probable septic shock with necrotic foot ulcers and necrotizing fasciitis and underwent bilateral lower limb amputations. The patient fulfilled the Streptococcal Toxic Shock Syndrome (STSS) criteria as defined by The Working Group on Severe Streptococcal Infections. These criteria were created for group A Streptococcus (Streptococcus pyogenes). Our patient fulfilled the Working Group’s criteria, except that the blood culture was positive for group B Streptococcus (Streptococcus agalactiae). Numerous studies demonstrate the importance of early detection and antibiotic treatment for GBS infections in general and early surgical management for necrotizing soft tissue infections (NSTIs) such as necrotizing fasciitis. (GBS women However cancer 77yearold yearold 77 year old type2 type 2 type- hypertension amputations STSS (STSS Infections pyogenes. pyogenes . pyogenes) Groups s agalactiae. agalactiae) NSTIs (NSTIs 7

https://doi.org/10.4322/acr.2024.497

15.

Drench of humic acid mitigate the adverse impacts of alkalinity on rose
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Mordai, Sahar

; Amiri, Jafar

; Jabbarzadeh, Zohreh

; Rasouli-Sadaghiani, MirHassan

; Shaygan, Ali

Ornamental Horticulture

Métricas do periódico
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2024, Volume 30 elocation e242710

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O estresse alcalino é um importante fator ambiental que limita o crescimento e a produtividade das roseiras. O ácido húmico (AH) é uma substância natural que demonstrou ter vários efeitos benéficos no crescimento das plantas e na tolerância ao estresse. As rosas (Rosa hybrida L.) estão entre as flores de corte mais importantes e populares do mundo, dominando o mercado de exportação de flores de corte. Este estudo investigou os efeitos da aplicação de AH nas propriedades fisiológicas e bioquímicas de roseiras cultivadas em condições alcalinas. Foi utilizado delineamento inteiramente casualizado com três repetições. Cada repetição consistiu de dois vasos contendo uma única planta de rosa. O ácido húmico foi aplicado nas doses de 0, 500, 1.000 e 2.000 mg L-1 via solo em intervalos de 15 dias durante dois meses. Plantas tratadas com 1.000 mg L-1 de HA exibiram níveis significativamente mais elevados de proteína total, prolina, atividade de catalase, atividade de guaiacol peroxidase e capacidade antioxidante. As plantas controle (que não receberam AH) apresentaram os maiores níveis de malondialdeído e vazamento de eletrólitos, indicando maior dano celular. Plantas tratadas com 500 mg L-1 de HA apresentaram maior teor de açúcar e atividade de ascorbato peroxidase. No geral, os resultados deste estudo sugerem que a aplicação de AH pode ser uma estratégia eficaz para melhorar a tolerância das roseiras ao stress alcalino e aumentar o seu crescimento e produtividade em solos alcalinos. (AH Rosa L. L mundo alcalinas repetições rosa 0 1000 1 000 1.00 2000 2 2.00 L1 L- meses total prolina catalase antioxidante eletrólitos celular 50 geral alcalinos 100 00 1.0 200 2.0 5 10 1. 20 2.

Abstract Alkaline stress is a major environmental factor that limits the growth and productivity of rose plants. Humic acid (HA) is a natural substance that has been shown to have various beneficial effects on plant growth and stress tolerance. Roses (Rosa hybrida L.) are among the world's most important and popular cut flowers, dominating the cut flower export market. This study investigated the effects of HA application on the physiological and biochemical properties of rose plants grown under alkaline conditions. A randomized complete design with three replicates was used. Each replicate consisted of two pots containing a single rose plant. Humic acid was applied at 0, 500, 1,000, and 2,000 mg L-1 through drenching at 15-day intervals for two months. Plants treated with 1,000 mg L-1 HA exhibited significantly higher levels of total protein, proline, catalase activity, guaiacol peroxidase activity, and antioxidant capacity. Control plants (receiving no HA) showed the highest levels of malondialdehyde and electrolyte leakage, indicating greater cellular damage. Plants treated with 500 mg L-1 HA displayed the highest sugar content and ascorbate peroxidase activity. Overall, the results of this study suggest that HA application can be an effective strategy to improve the tolerance of rose plants to alkaline stress and enhance their growth and productivity in alkaline soils. (HA Rosa L. L worlds world s flowers market conditions used 0 1000 1 000 2000 2 2,00 L1 L- 15day day 15 months 1,00 protein proline activity capacity receiving leakage damage 50 Overall soils 100 00 200 2,0 1,0 5 10 20 2, 1,

https://doi.org/10.1590/2447-536x.v30.e242710

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