Abstract Objective: The objective of the study was to study the incidence of granular cell tumor of the breast (GCTB) in the population of the General Hospital of Mexico, a lesion that is clinically and radiologically confused with breast carcinoma. Materials and methods: Search the database of the Surgical Pathology Unit, the cases of Tumor of Granular Breast Cell, during the period 2002 to 2020. Results: Two cases of GCTB were found in women aged 59 years and 64 years, respectively. One of the cases was discovered in the mammary skin, a product of infiltrating ductal carcinoma mastectomy and the other was a granular cell tumor (GCT), which was clinically considered breast carcinoma. Hence, lumpectomy and sentinel lymph node dissection were performed. The two tumors showed clinical and histopathological features consistent with benign GCTB. Conclusion: GCTB occurs in 0.1% of breast tumors and 6% of GCT. It is clinically and radiologically confused with breast carcinoma, therefore, histopathological studies together with immunohistochemistry are valuable tools, in the correct diagnosis, which prevents an inappropriate treatment.

Abstract Objective: Jaw osteosarcoma shows a variety of histomorphological clinical conditions. Despite the advances in molecular pathogenesis and biological markers, clinicopathological correlation is considered the most important criterion in diagnosis. Material and methods: The database of the Surgical Pathological Department of the General Hospital of Mexico was reviewed to obtain cases of osteosarcoma during the period from 2002 to 2019. The cases were evaluated on the Enneking scale, which has prognostic considerations. Results: Regarding the 11 cases found, 54.5% are women. The average age was 36 years old, the primary location was the jaw. The average size was 8 cm. Clinicopathological concordance was 27.3%. The most frequent histologic variant was chondroblastic. The predominant histological grade was high and 83% of the cases had surgical margins involved. Conclusion: The patients were in the fourth decade of their life, the tumors were large in size with a high histological grade of malignity and the majority of cases had affected surgical margins. All data had a bad prognostic.

The gastrointestinal stromal tumors (GISTs) are neoplasms of mesenchymal origin; they represent 0.3% of neoplasm in the digestive tube. They are defined by the expression of CD117, a tyrosine kinase receptor of the growth factor. Our objective is to know the clinical, pathological, and immunohistochemical characteristics in the population who attend the general hospital of Mexico. The cases of mesenchymal tumors in the digestive system during the period of July 2010-May 2017 were revised. Fifty-four cases of GIST were found; in all cases, clinical data and the macroscopic aspect were studied, and microscopy and immunohistochemical characteristics were also checked. These cases are more frequent in women, in a proportion of 1.2:1, with an average age of 54-year-old. The treatment was full surgery, in 4 of them, a lymphadenectomy was done, and metastasis was found in one case. The average size of the tumors was 8 cm. The predominant histological pattern was fusocellular (81.5%), followed by epithelioid patterns (7.4%) and mixed (11.1%). The main locations were the stomach (48.1%), small intestine (40.7%), rectum (5.6%), omentum (3.7%), and mesentery (1.9%). The malignant potential according to Fletcher's criteria were very low malignant potential (20.5%), low malignant potential (25%), intermediate potential (20.5%), and high malignant potential (34.1%). All cases were positive for CD117.

Abstract: This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Complete data from 60 cases were evaluated. They were more common in males (mean age = 63.9 years). Unexpectedly a high rate of tumors (38.3%) were in the base of the tongue (BT). Moderately and poorly differentiated SCCT were the most common. 16.7% presented lymph node invasion, 15% were recurrent tumors and BT carcinomas recurred more frequently. A high rate (81.7%) were stage II and 48.3% were low-risk patients. SCCTs in the studied population displayed different clinico-pathological and behavioral features compared with worldwide data. Our results suggest that BT tumors should be treated more aggressively than those in the mobile tongue. BT located tumors were more frequent than previously published. Additional frequency studies will define outcomes in age cohorts with a consensus cut-off for young and elderly populations. More population-based studies should be performed in Latin American regions to acquire accurate data on SCC incidence in elder subpopulations and to identify precisely the etiological factors in these patients.