Abstract: The COVID-19 outbreak commenced in Wuhan, China, in December 2019 and swiftly disseminated worldwide. On March 11, 2020, the World Health Organization (WHO) formally designated the COVID-19 outbreak as a global pandemic [1]. This highly contagious disease, which has also started to spread among young people, necessitates the implementation of policies to avert the collapse of hospitals due to shortages in beds, mechanical ventilators, and intensive care units. Using the record from March 2020 to May 31 2021, (before the arrival of vaccines in Mexico) of the website of the General Directorate of Epidemiology of the Ministry of Health of the Government of the Mexican Republic, with more than seven million people associated with COVID-19, a model is built with twelve characteristics that predicts the risk of death associated with COVID-19, applying Supervised Learning Algorithms such as Linear Regression, Naive Bayes, Decision Trees and Random Forests. The results of the machine learning algorithms show a performance of 87%. Subsequently, the model was tested again with 402,116 COVID-19-associated patients from the month of June, achieving an accuracy of 91%, surpassing the model proposed in [3]. When performing data cleaning, we observed that the twelve variables are not correlated, unlike what the authors showed in [4], where data cleaning was not carried out. This analysis can aid in designing strategies and policies to combat its spread and prevent mortality, as well as assist hospitals in prioritizing the care of higher-risk patients.

RESUMO Introdução: A redução da carga pelo método das repetições máximas (RM) pode ser necessária para promover maior número de repetições e, consequentemente, maior volume total, tempo sob tensão e classificações do esforço percebido. Objetivo: Comparar os efeitos de diferentes cargas do exercício leg press no número de repetições, volume total, tempo sob tensão e percepção de esforço. Métodos: Dezoito universitárias (23,9 ± 3,8 anos) realizaram duas sessões experimentais com 90% e 100% de 10-12 RM em desenho transversal balanceado. Resultados: O número de repetições da segunda e terceira séries, volume total e tempo sob tensão a 90% de 10-12 RM foi estatisticamente maior do que a 100% de 10-12 RM (p < 0,05). A percepção do esforço da primeira e segunda séries e a carga de treinamento (percepção do esforço x duração das sessões) foram maiores na sessão realizada com 100% de 10-12 RM (p < 0,05). Conclusão: Uma pequena redução da carga resulta em maior número de repetições, volume total e tempo sob tensão. A sessão com maior carga induziu maior percepção do esforço e carga de treinamento. Assim, cientistas e treinadores podem considerar cargas menores para maximizar o número de repetições, o volume total e o tempo sob tensão, o que pode causar maiores adaptações musculares a longo prazo. Nível de evidência II; Estudo prospectivo comparativo.

ABSTRACT Introduction: Load reduction using the repetition maximum (RM) method may be necessary to promote higher numbers of repetitions, and consequently, higher total volume, time under tension, and perceived exertion ratings. Objective: To compare the effects of different leg press exercise loads on number of repetitions, total volume, time under tension, and perceived exertion. Methods: Eighteen women university students (23.9 ± 3.8 years) performed two experimental sessions with 90% and 100% of 10-12 RM in a balanced crossover design. Results: The number of repetitions of the second and third sets, the total volume, and time under tension at 90% of 10-12 RM was statistically higher than at 100% of 10-12 RM ( p < 0.05). The perceived exertion of the first and second sets and the training load (perceived exertion x duration of sessions) were higher at 100% of the 10-12 RM session ( p < 0.05). Conclusion: A small reduction in load results in a greater number of repetitions, total volume, and time under tension. The session with the higher load appeared to induce higher perceived exertion and training load. Thus, scientists and coaches might consider lower loads to maximize the number of repetitions, total volume, and time under tension, which may cause greater long-term muscular adaptations. Level of evidence II; Comparative prospective study.

RESUMEN Introducción: La reducción de la carga por el método de las repeticiones máximas (RM) puede ser necesaria para promover un mayor número de repeticiones y, consecuentemente, un mayor volumen total, tiempo bajo tensión y calificaciones del esfuerzo percibido. Objetivo: Comparar los efectos de diferentes cargas del ejercicio de prensa de piernas sobre el número de repeticiones, volumen, tiempo bajo tensión y esfuerzo percibido. Métodos: Dieciocho estudiantes universitarios (23,9 ± 3,8 años) realizaron dos sesiones experimentales con el 90% y el 100% de 10-12 RM en un diseño trasversal equilibrado. Resultados: El número de repeticiones de la segunda y tercera serie, el volumen total y el tiempo bajo tensión al 90% de 10-12 RM fue estadísticamente mayor que al 100% de 10-12 RM (p < 0,05). El esfuerzo percibido de la primera y segunda serie y la carga de entrenamiento (esfuerzo percibido x duración de las sesiones) fueron superiores en la sesión realizada al 100% de 10-12 RM (p < 0,05). Conclusión: Una pequeña reducción de la carga da lugar a un mayor número de repeticiones, volumen total y tiempo bajo tensión. La sesión con mayor carga indujo un mayor esfuerzo percibido y carga de entrenamiento. Por lo tanto, los científicos y entrenadores pueden considerar cargas más bajas para maximizar el número de repeticiones, el volumen total y el tiempo bajo tensión, lo que puede causar mayores adaptaciones musculares a largo plazo. Nivel de evidencia II; Estudio prospectivo comparativo.

Abstract. This article summarizes the clinical practice guide (CPG) for the management of patients with atrial fibrillation (AF) in the Social Security of Peru (EsSalud). Objective. To provide clinical recommendations based on evidence for the management of patients with AF in EsSalud. Methods. A CPG for the management of patients with AF in EsSalud was developed. To this end, a guideline development group (GDG) was established, including medical specialists and methodologists. The GDG formulated 9 clinical questions to be answered by this CPG. Systematic searches of systematic reviews and, when it was considered pertinent, primary studies were conducted in Medline during 2017. The evidence to answer each of the posed clinical questions was selected. The quality of the evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. In periodic work meetings, the GDG used the GRADE methodology to review the evidence and formulate the recommendations, points of good clinical practice, and the flowchart of the CPG. Finally, the CPG was approved with Resolution No. 91 - IETSI - ESSALUD - 2018. Results. This CPG addressed 9 clinical questions, divided into three topics: prevention of thromboembolic events, maintenance therapy and management of AF. Based on these questions, 12 recommendations (6 strong recommendations and 6 weak recommendations), 29 points of good clinical practice, and 2 algorithms were formulated. Conclusion. This article summarizes the methodology and evidence-based conclusions from the CPG for the management of AF in EsSalud.

Introducción. El presente artículo resume la guía de práctica clínica (GPC) para el manejo de pacientes con fibrilación auricular (FA) en el Seguro Social del Perú (EsSalud). Objetivo. Proveer recomendaciones clínicas basadas en evidencia para el manejo de pacientes con FA en EsSalud. Métodos. Se conformó un grupo elaborador (GEG) que incluyó médicos especialistas y metodólogos. El GEG formuló 9 preguntas clínicas a ser respondidas por la presente GPC. Se realizó búsquedas sistemáticas de revisiones sistemáticas y, cuando fue considerado pertinente, estudios primarios en Medline durante el 2017. Se seleccionó la evidencia para responder cada una de las preguntas clínicas planteadas. La certeza de la evidencia fue evaluada usando la metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE). En reuniones de trabajo periódicas, el GEG usó la metodología GRADE para revisar la evidencia y formular las recomendaciones, los puntos de buenas prácticas clínicas y los flujogramas de la GPC. Finalmente, la GPC fue aprobada con Resolución N° 91 - IETSI - ESSALUD - 2018. Resultados. La presente GPC abordó 9 preguntas clínicas, divididas en tres temas: prevención de eventos tromboembólicos, estrategias de control y manejo de FA en emergencias. En base a dichas preguntas se formularon 12 recomendaciones (6 recomendaciones fuertes y 6 recomendaciones condicionales), 29 puntos de buena práctica clínica, y 2 algoritmos. Conclusión. El presente artículo resume la metodología y las conclusiones basadas en evidencias de la GPC para manejo de pacientes con FA en EsSalud.

Este trabalho teve como objetivo avaliar o desempenho produtivo e os aspectos econômicos de dez clones de seringueira [Hevea brasiliensis (Willd. ex Adr. de Juss.) Muell. Arg.] em diferentes freqüências de sangria e com estimulação à base de ethefon. O experimento foi instalado na Fazenda Indiana, no município de Indiana, SP, sob o delineamento de blocos ao acaso com parcelas subdivididas. Os tratamentos principais foram os clones GT 1, RRIM 701, RRIM 600, PB 235, PR 261, PB 252, Fx 4098, Fx 2261, Fx 3864 e IAN 873, submetidos a três sistemas de sangria: 1/2S d/2 6d/7 (testemunha), 1/2S d/4 6d/7.10m/y. ET 5,0% Ba 10y e 1/2S d/6 6d/7.10m/y. ET 5,0% Ba 10/y. As variáveis estudadas foram: perímetro do caule, produção, secamento do painel e os aspectos econômicos. Os resultados mostraram superioridade no sistema 1/2S d/2 6d/7 na maioria dos clones, exceto o GT 1 e o PB 235, que no sistema 1/2S d/4 ET 5,0% apresentaram ganhos líquidos de 12,0% e 54,0%, respectivamente, acima do obtido no sistema testemunha. Somente os clones Fx 3864 e PB 235 apresentaram ganhos líquidos de 18,0% e 28,0% no sistema 1/2S d/6 ET 5% superiores em relação ao obtido no sistema testemunha. A maior porcentagem de secamento do painel foi observada no clone PB 235 no sistema 1/2S d/4 ET 5,0%.

The objective of this paper was to evaluate yield of performance and economic aspects of ten clones of rubber tree [Hevea brasiliensis (Willd. ex. Adr. de Juss.) Muell. Arg.] in different frequencies of tapping and with stimulation with ethefon. The trial was placed at the Indiana farm, in the county of Indiana, SP, Brazil, under a split-plot design. The main treatments were the GT 1, RRIM 701, RRIM 600, PB 235, PR 261, PB 252, Fx 4098, Fx 2261, Fx 3864 and IAN 873 clones submitted to three systems of tapping 1/2S d/2 6d/7 (check), 1/2S d/4 6d/7.10m/y. ET 5.0% Ba 10y and 1/2S d/6 6d/7.10m/y. ET 5.0% Ba 10y. The variables were: girth increment, yield, panel desiccation and economic aspects. Results indicated superiority in the 1/2S d/2 6d/7 system in most of the clones, except for GT 1 and PB 235 clones, that in the 1/2S d/4 ET 5.0% system showed superiority of net gain of 12.0% and 54.0%, respectively, compared with the check tapping system. Only the Fx 3864 and PB 235 clones showed liquid gain of 18.0% and 28.0%, respectively, in the 1/2S d/6 ET 5.0% system, compared with the check. The highest incidence of panel desiccation was observed in the PB 235 clone in the 1/2S d/4 ET 5.0% system.