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With the increase in life expectancy and the significant incidence of lesions of the musculoskeletal system, both the public and private sectors seek improvements in their products and processes in order to contribute to the health of the population. Every year tons of chicken eggshell (CES) from domestic consumption are released in environment and the present work aims the production of a synthetic ceramic bone substitute using the eggshell as a source of calcium ions. According to the methodology, 5, 10, 15 and 20 mol% of iron ions were used and the characterization assays demonstrated the formation of a double calcium iron phosphate - Ca9Fe(PO4)7. MG63 cells were cultured on test specimens to cell viability assay and to each doped group analyzed, verifying cell compatibility with the studied compounds, as well as a good adhesion profile. Scanning electron microscopy (SEM) of the cells showed that material surface favored cell adhesion and the results demonstrated that the production of the compounds were viable to Ca9Fe(PO4)7 phase. So, in the future, it will be possible to have a final comprehensive biological compatibility of the prototype for further in vitro and in vivo assays. system population CES (CES methodology 5 10 1 2 mol Ca9FePO47. Ca9FePO47 CaFePO Ca9Fe PO4 7. 7 Ca Fe PO MG MG6 analyzed profile SEM (SEM Ca9Fe(PO4) phase So future FePO Ca9FePO4 CaFe Ca9Fe(PO4 Ca9FePO Ca9Fe(PO

https://doi.org/10.21577/0103-5053.20240191

Chemical Composition and Larvicidal Activity of Essential Oil Extracted from Anemia tomentosa (SAV.) Sw: Study Conducted in vitro and in silico SAV. SAV (SAV. Sw (SAV
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Jesus, Vilisaimon S. de

; Leite, Juliana L.

; Sousa, Jailan S.

; Barbosa, Fabricio S.

; Oliveira, Djalma M. de

; Barreto, Rubens S.

; Soares, Wagner R. A.

; Andrade, Bruno S.

; Gualberto, Simone A.

; Silva, Débora C. da

; Guimarães, Isabelly D. S.

; Silva, Luiza F.

; Aguiar, Rosane M.

Journal of the Brazilian Chemical Society

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2025, Volume 36 Nº 2 elocation e-20240127

Resumo: En | Texto: En | PDF: En

The essential oil extracted from Anemia tomentosa (EOAT) has shown larvicidal potential against Aedes aegypti, based on methods in vitro and in silico. Chromatographic and spectrometric techniques (gas chromatography-mass spectrometry (CG-MS), gas chromatography-flame ionization detector (GC-FID)), as well as mono and bidimensional nuclear magnetic resonance spectroscopy (NMR) were used to assess 10 essential oil components. Chemical composition of essential oil comprised 87.51% sesquiterpenes, with emphasis on presilphiperfolan-1-ol (42.13%) and silphiperfol-5-ene (19.47%). Larvicidal assay conducted in vitro with EOAT has evidenced potential cytotoxic activity up to 48 h exposure to it; mortality rate observed for A. aegypti larvae exposed to essential oil reached 100%. Study conducted in silico with chemical compounds deriving from the herein investigated plant species has evidenced its potential to inhibit acetylcholinesterase in A. aegypti. Activity of triquinane sesquiterpenes ranging from -6.8 to -8.2 kcal mol-1 stood out in comparison to that of temephos (-7.5 kcal mol-1). Chemical compounds identified in the investigated essential oil presented low human and environmental toxicity, as observed in absorption, distribution, metabolism and excretion, and toxicity (ADMETox) predictions. (EOAT chromatographymass chromatography mass CGMS, CGMS CG MS , (CG-MS) chromatographyflame flame GCFID, GCFID GC FID (GC-FID)) NMR (NMR 1 components 8751 87 51 87.51 presilphiperfolan1ol presilphiperfolanol presilphiperfolan ol 42.13% 4213 42 13 (42.13% silphiperfol5ene silphiperfolene silphiperfol 5 ene 19.47%. 1947 19.47% . 19 47 (19.47%) 4 it A 100 100% 6.8 68 6 8 -6. 8.2 82 2 -8. mol1 mol mol- 7.5 75 7 (-7. mol1. mol-1) absorption distribution excretion ADMETox (ADMETox predictions (CG-MS (GC-FID) 875 87.5 42.13 421 (42.13 194 19.47 (19.47% 6. -6 8. -8 7. (-7 (GC-FID 87. 42.1 (42.1 19.4 (19.47 - (- 42. (42. 19. (19.4 ( (42 (19. (4 (19 (1

https://doi.org/10.21577/0103-5053.20240127

In vitro and in silico Antifungal Activity of Metabolites from Bredemeyera brevifolia (Benth.) Klotzsch ex A.W. Benn. Benth. Benth (Benth. AW A W A.W Benn (Benth
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Barreto, Rubens S.

; Costa, Diego M. da

; Sousa, Jailan S.

; Jesus, Vilisaimon S. de

; Silva, Agnaldo P. da

; Buonafina-Paz, Maria Daniela S.

; Santos, Franz A. G. dos

; Neves, Rejane P.

; Pastore, José F. B.

; Andrade, Bruno S.

; Soares, Wagner R. A.

; Brandão, Hugo N.

; Aguiar, Rosane M.

; Alves, Clayton Q.

Journal of the Brazilian Chemical Society

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2025, Volume 36 Nº 3 elocation e-20240158

Resumo: En | Texto: En | PDF: En

Bredemeyera Willd. is a genus of the Polygalaceae family, occurring in Brazil. This research aims to evaluate the phytochemical and antifungal potential, in vitro and in silico, of Bredemeyera brevifolia extracts. The identification of fatty acids by gas chromatography-mass spectrometry and their quantification by gas chromatography-flame ionization detector showed that palmitic (36.55 mg g−1), margaric (3.66 mg g−1), linolelaidic (108.82 mg g−1), oleic (7.86 mg g−1), stearic (41.11 mg g−1), dihomo-γ-linolenic (85.48 mg g−1), and arachidic (209.00 mg g−1) acids are present in the hexane extract. From the chloroform extract, 1-hydroxy-3,7-dimethoxyxanthone was isolated and identified. The minimum inhibitory concentration assay with methanolic extract demonstrated antifungal activity against species of the genus Candida, Sporothrix, and Trichophyton for up to 96 h, with values ranging from 64-1024 μg mL−1. The in silico study with the chemical compounds of this species showed fungal inhibition potential of sterol-14-α-demethylase, highlighting 1-hydroxy-3,7-dimethoxyxanthone, which presented an affinity energy of -8.8 kcal mol−1, greater than that observed for fluconazole (−8.3 kcal mol−1). The fatty acids interacted with the active site of the enzyme but presented energies ≥ −7.4 kcal mol−1. Compounds isolated from this species have pharmacokinetic potential for the development of pharmaceutical formulations. Willd family Brazil extracts chromatographymass chromatography mass chromatographyflame flame 36.55 3655 36 55 (36.5 g−1, g1 g g−1 , 1 3.66 366 3 66 (3.6 108.82 10882 108 82 (108.8 7.86 786 7 86 (7.8 41.11 4111 41 11 (41.1 dihomoγlinolenic dihomo γ linolenic 85.48 8548 85 48 (85.4 209.00 20900 209 00 (209.0 1hydroxy3,7dimethoxyxanthone 1hydroxy37dimethoxyxanthone hydroxydimethoxyxanthone hydroxy 3,7 dimethoxyxanthone identified Candida Sporothrix 9 h 641024 64 1024 64-102 mL1 mL mL−1 sterol14αdemethylase, sterol14αdemethylase sterolαdemethylase sterol 14 α demethylase, demethylase sterol-14-α-demethylase 1hydroxy3,7dimethoxyxanthone, dimethoxyxanthone, 8.8 88 8 -8. mol1 mol mol−1 −8.3 83 (−8. . mol−1) 74 4 −7. formulations 36.5 365 5 (36. g− 3.6 6 (3. 108.8 1088 10 (108. 7.8 78 (7. 41.1 411 (41. 85.4 854 (85. 209.0 2090 20 0 (209. 1hydroxy3 7dimethoxyxanthone 37 3, 64102 102 64-10 mL− αdemethylase 8. -8 mol− −8. (−8 −7 36. (36 3. (3 108. (108 7. (7 41. (41 85. (85 209. 2 (209 1hydroxy 6410 64-1 - −8 (− − ( (10 (4 (8 (20 641 64- (1 (2

https://doi.org/10.21577/0103-5053.20240158

Evaluation of spontaneous and weedy flora of vineyards for ecosystem services provision using the indicator VIFLORES
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Aguiar, Francisca C.

; Pires, Beatriz R.

; Lopes, Carlos M.

Revista de Ciências Agrárias

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Mar 2024, Volume 47 Nº 1 Páginas 591 - 600

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Spontaneous flora of vineyards in the Mediterranean region has lately been receiving much attention, due to the increasing awareness of their benefits for agroecosystems, soils, and for provisioning multiple Ecosystem Services (ES). However, initiatives for valuing flora often clash with the potential losses by interference with vines, but in an extent difficult to evaluate. We developed the index VIFLORES - VIneyard FLORa Value for Ecosystem Services -, aiming to assess the value of spontaneous plant species for ES provision in vineyards. VIFLORES ranges from 0 (lowest value) to 1 (maximum), calculated by the average of the contribution of the co-occurring species to the three ES categories: Provisioning (e.g. medicinal use), Regulation and Maintenance (e.g. pollination), and Cultural Services (e.g. landscape aesthetics). To map and compare the floristic values of vineyards, we propose an integration of species abundance, phenology and VIFLORES. To test this approach, we carried out 192 floristic surveys in Spring 2021 for three vineyards located in the Alentejo winegrowing region (South of Portugal) with different production management systems, namely Conventional (CPS), Integrated in Optidose (IPS), and Organic (OPS). IPS and OPS inter rows were significantly more diverse than CPS and had a high VIFLORES value. OPS vineyard rows had significantly higher diversity and indicator values than CPS and IPS, which is likely related to soil management. While VIFLORES approach guides to fostering of multifunctional vineyards, it is still limited in incorporating the seasonality of weedy flora and needs validated thresholds for better decisions on soil management.

Resumo A flora espontânea das vinhas na região mediterrânea tem sucitado grande interesse recentemente, devido à crescente consciencialização dos seus benefícios para os agroecossistemas, o solo e no fornecimento de Serviços dos Ecossistemas (SE). No entanto, é comum estas iniciativas de valorização da flora colidirem com as perdas por interferência com as videiras. Neste trabalho, desenvolveu-se o indicador VIFLORES- Valor da Flora das Vinhas para Serviços dos Ecossistemas-, com o objetivo de avaliar a importância da flora das vinhas. O VIFLORES varia de 0 a 1 e é calculado pela média da contribuição das espécies para três categorias de SE: Provisão (ex. uso medicinal), Regulação e Manutenção (ex. polinização) e Serviços Culturais (ex. estética da paisagem). Para mapear e comparar os valores florísticos das vinhas, propomos uma integração da densidade das espécies, da fenologia e do VIFLORES. Para testar esta abordagem, realizámos 192 levantamentos florísticos na primavera de 2021 em três vinhas da região vinícola do Alentejo, sul de Portugal, com diferentes modos de produção: Convencional (CPS), Integrado em Optidose (IPS) e Biológico (BPS). As entrelinhas das vinhas IPS e BPS foram significativamente mais diversas que as CPS e apresentaram um maior VIFLORES. As linhas BPS apresentaram valores de diversidade e indicadores significativamente mais elevados que as CPS e IPS, o que poderá estar relacionado com a gestão do solo. Embora a abordagem VIFLORES oriente para a promoção de vinhas multifuncionais, ainda é limitada na incorporação da sazonalidade da flora espontânea e necessita de validação para uma melhor decisão na gestão do solo.

https://doi.org/10.19084/rca.35062

Portuguese version of the Literacy Independent Cognitive Assessment (LICA) instrument in the evaluation of individuals aged 50 years or older with Itabaianinha syndrome LICA (LICA 5
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Santos, Lucas B.

; Kellner, Michael

; Lisboa, Walter

; Faro, André

; Oliveira, Carla R. P.

; Batista, Vanderlan O.

; Oliveira-Santos, Alécia A.

; Brito, Íris de Vita Alves de

; Marinho, Cindi G.

; Campos, Viviane C.

; Villar-Gouy, Keila R.

; Leal, Ângela C.

; Amorim, Rivia S.

; Melo, Enaldo V.

; Santos, Elenilde G.

; Salvatori, Roberto

; Aguiar-Oliveira, Manuel H.

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230265

Resumo: En | Texto: En | PDF: En

ABSTRACT Objectives Individuals with congenital isolated growth hormone deficiency (IGHD) in Northeastern Brazil have a normal lifespan with a prolonged healthspan. We hypothesize that their increased healthspan is accompanied by a reduced cognitive decline during aging. We have recently shown that these individuals have a similar total cognitive function and better attention and executive function than controls. These data were obtained using a Portuguese version of the Literacy Independent Cognitive Assessment (LICA) instrument, whose translation to facilitate cognitive research in Portuguese-speaking countries is described here. Subjects and methods In the first stage, a psychologist and a psychiatrist translated the LICA instrument from English into Portuguese, and an English teacher proofread the translation. The second stage included its synthesis and cultural adaptation, carried out by Brazilian authors, and changes in some words and images. The third stage involved an evaluation round with two referees (independent psychologists). The fourth stage involved a back translation of the instrument, which demonstrated > 95% agreement with the original version. The fifth stage included a study to verify the understanding of the questionnaire by responders. In the sixth stage, an endocrinologist and a psychiatrist approved the final Portuguese version of the instrument, which was then administered to 15 individuals with IGHD and 15 controls older than 50 years. Results The LICA instrument was applied 59 times (5 times in the pilot study, 24 in the variability studies, and 30 in the experimental step). The interobserver and intraobserver variabilities were 99% and 96%, respectively. Cronbach’s alpha was 0.76, indicating good reliability. The mean (± standard deviation) duration of the application was 39 ± 8.6 and 48.5 ± 5.8 minutes in literate and illiterate individuals, respectively. Conclusion The Portuguese version of the LICA instrument was valuable for the cognitive assessment of individuals with Itabaianinha syndrome. (IGHD aging (LICA Portuguesespeaking speaking here adaptation authors images independent psychologists. psychologists . psychologists) 95 responders 1 5 years ( 2 studies 3 step. step step) 99 96 96% respectively Cronbachs Cronbach s 076 0 76 0.76 reliability deviation 86 8 6 8. 485 48 48. 58 5. syndrome 9 07 7 0.7 4 0.

https://doi.org/10.20945/2359-4292-2023-0265

Patients hospitalized with active tuberculosis and Covid-19 coinfection: A matched case-control from the Brazilian Covid-19 Registry Covid19 Covid 19 Covid-1 coinfection casecontrol case control Covid1 1 Covid-
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CARVALHO, RAFAEL L.R.

; AGUIAR, GABRIELLA G.

; MOREIRA, JESSICA F.B.

; PEREIRA, DANIELLA N.

; AUGUSTO, VALÉRIA MARIA

; SCHWARZBOLD, ALEXANDRE V.

; MATOS, CAROLINA C.

; RIOS, DANYELLE R.A.

; COSTA, FELÍCIO R.

; ANSCHAU, FERNANDO

; CHATKIN, JOSÉ MIGUEL

; RUSCHEL, KAREN B.

; CARNEIRO, MARCELO

; OLIVEIRA, NEIMY R. DE

; PARAÍSO, PEDRO G.

; AGUIAR, RUBIA LAURA O.

; GRIZENDE, GENNA MAIRA S.

; MARCOLINO, MILENA S.

Anais da Academia Brasileira de Ciências

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2024, Volume 96 Nº 1 elocation e20230791

Resumo: En | Texto: En | PDF: En

Abstract Although control of Covid-19 has improved, the virus continues to cause infections, such as tuberculosis, that is still endemic in many countries, representing a scenario of coinfection. To compare Covid-19 clinical manifestations and outcomes between patients with active tuberculosis infection and matched controls. This is a matched case-control study based on data from the Brazilian Covid-19 Registry, in hospitalized patients aged 18 or over with laboratory confirmed Covid-19 from March 1, 2020, to March 31, 2022. Cases were patients with tuberculosis and controls were Covid-19 patients without tuberculosis. From 13,636 Covid-19, 36 also had active tuberculosis (0.0026%). Pulmonary fibrosis (5.6% vs 0.0%), illicit drug abuse (30.6% vs 3.0%), alcoholism (33.3% vs 11.9%) and smoking (50.0% vs 9.7%) were more common among patients with tuberculosis. They also had a higher frequency of nausea and vomiting (25.0% vs 10.4%). There were no significant differences in in-hospital mortality, mechanical ventilation, need for dialysis and ICU stay. Patients with TB infection presented a higher frequency of pulmonary fibrosis, abuse of illicit drugs, alcoholism, current smoking, symptoms of nausea and vomiting. The outcomes were similar between them. Covid19 Covid 19 Covid-1 improved infections countries coinfection casecontrol case Registry 1 2020 31 2022 13636 13 636 13,63 Covid19, 19, 3 0.0026%. 00026 0.0026% . 0 0026 (0.0026%) 5.6% 56 5 6 (5.6 0.0%, 00 0.0% , 0.0%) 30.6% 306 30 (30.6 3.0%, 3.0% 3.0%) 33.3% 333 33 (33.3 11.9% 119 11 9 50.0% 500 50 (50.0 9.7% 97 7 25.0% 250 25 (25.0 10.4%. 104 10.4% 10 4 10.4%) inhospital hospital mortality ventilation stay drugs them Covid1 Covid- 202 1363 63 13,6 0002 0.0026 002 (0.0026% 5.6 (5. 0.0 30.6 (30. 3.0 33.3 (33. 11.9 50.0 (50. 9.7 25.0 2 (25. 10.4 20 136 13, 000 0.002 (0.0026 5. (5 0. 30. (30 3. 33. (33 11. 50. (50 9. 25. (25 10. 0.00 (0.002 ( (3 (2 (0.00 (0.0 (0. (0

https://doi.org/10.1590/0001-3765202420230791

Stochastic Sensing of Organotin Compounds with Alpha-Hemolysin Nanopore AlphaHemolysin Alpha Hemolysin
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Silva, Artur A. R.

; Silva Júnior, Janilson J.

; Machado, Dijanah C.

; Pontes, Frederico J. S.

; Pol-Fachin, Laércio

; Aguiar, Juliana P.

; Rodriguesa, Claudio G.

Journal of the Brazilian Chemical Society

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2024, Volume 35 Nº 2 elocation e-20230127

Resumo: En | Texto: En | PDF: En

Organotin compounds (OTCs) are pollutants that affect the reproduction of some marine organisms and can cause autoimmune diseases in humans. Most of the techniques used for detection and monitoring of OTCs in the environment have limitations due to several stages of sample pre-processing. Here, we demonstrated the use of the α-hemolysin (αHL) nanopore as an alternative platform for the detection of the cyhexatin and diphenyltin dichloride (DPhT) in aqueous systems. The detection process is based on the analysis of the residence times of each OTCs within the unitary nanopore, as well as, on the amplitudes of the blockages in the ionic current flowing through it. Cyhexatin and DPhT induced two and three patterns in the amplitude of the blockages in the ionic current, respectively. Residence time value of the cyhexatin inside the nanopore was higher than the value presented by the DPhT. Molecular docking was used to evaluate the interactions between OTCs and nanopore constriction, mainly identifying cation-π and hydrogen interactions. Classical atomistic molecular dynamic simulations confirm moderate aggregative behavior of these OTCs in solution in cationic form, especially for cyhexatin species. The nanopore detects OTCs at nanomolar level and it is possible to use this nanopore to monitor OTCs in aqueous systems. (OTCs humans preprocessing. preprocessing pre processing. processing pre-processing Here αhemolysin α hemolysin αHL (αHL (DPhT systems respectively constriction cationπ cation π form species

https://doi.org/10.21577/0103-5053.20230127

Prognostic implications of the ID1 expression in acute myeloid leukemia patients treated in a resource-constrained setting ID resourceconstrained resource constrained
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Lima, Aleide S.

; Bezerra, Matheus F.

; Moreira-Aguiar, Amanda

; Weinhäuser, Isabel

; Santos, Bianca L.

; Falcão, Raul M.

; Salustiano-Bandeira, Maria L.

; Franca-Neto, Pedro L.

; Lima, Marinus M.

; Saldanha-Araujo, Felipe

; Coelho-Silva, Juan L.

; Pereira-Martins, Diego A.

; Bezerra, Marcos A.

; Lucena-Araujo, Antonio R.

Hematology, Transfusion and Cell Therapy

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2024, Volume 46 Nº 3 Páginas 250 - 255

Resumo: En | Texto: En | PDF: En

Abstract Introduction The aberrant expression of the inhibitor of DNA binding (ID1) gene has been frequently associated with the leukemogenesis and prognostication acute myeloid leukemia (AML), although its clinical importance has never been investigated in patients treated outside well-controlled clinical trials. Methods Using quantitative real-time polymerase chain reaction, we investigated the role of the ID1 expression in the clinical outcomes of non-selected patients with acute myeloid leukemia treated in a real-life setting. Results Overall, 128 patients were enrolled. Patients with high ID1 expression had a lower 3-year overall survival (OS) rate of 9%, with the 95% confidence interval (95%CI) at 3 to 20%, compared to patients with a low ID1 expression (22%, 95%CI: 11 - 34%) (p = 0.037), although these findings did not retain significance after adjustment (hazard ratio (HR): 1.5, 95%CI: 0.98 - 2.28; p = 0.057). The ID1 expression had no impact on post-induction outcomes (disease-free survival, p = 0.648; cumulative incidence of relapse, p = 0.584). Conclusions Although we are aware thar our data are confronted with many variables that cannot be fully controlled, including drug unavailability, risk-adapted treatment, comorbidities and the time from diagnosis to treatment initiation, we are firm believers that such an initiative can provide more realistic data on understudied populations, in particular those from low- and middle-income countries. ID (ID1 AML, AML , (AML) wellcontrolled well controlled trials realtime real reaction nonselected non selected reallife life setting Overall 12 enrolled 3year year OS (OS 9 9% 95 95%CI 95CI CI (95%CI 20 20% 22%, 22 (22% 1 34% 34 0.037, 0037 0.037 0 037 0.037) hazard HR (HR) 15 5 1.5 098 98 0.9 2.28 228 2 28 0.057. 0057 0.057 . 057 0.057) postinduction post induction diseasefree disease free 0.648 0648 648 relapse 0.584. 0584 0.584 584 0.584) unavailability riskadapted risk adapted initiation populations middleincome middle income countries (ID (AML 22% (22 003 0.03 03 (HR 1. 09 0. 2.2 005 0.05 05 0.64 064 64 058 0.58 58 (2 00 0.0 2. 0.6 06 6 0.5 (

https://doi.org/10.1016/j.htct.2023.04.005

Blood addition and processing conditions: Improving protein content and digestibility value of hydrolyzed feather meal conditions
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Sinhorini, Marcia Regina

; Balbinot-Alfaro, Evellin

; Aguiar, Wagner de

; Ferreira, Edilson da Silva

; Sbardelotto, Paula Regina Rabelo

; Alfaro, Alexandre da Trindade

Revista Brasileira de Zootecnia

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2024, Volume 53 elocation e20220108

Resumo: En | Texto: En | PDF: En

ABSTRACT The study aimed to optimize the processing conditions for hydrolyzed feather meal (HFM) with the addition of coagulated blood. Factorial design and response surface methodology were used to optimize processing conditions in function of protein content (%) and digestibility value (%) of HFM. Higher protein contents were obtained when the upper levels of the variables pressure (kgf.cm−2), hydrolysis time (min), and blood addition (%) were used in the process. Longer hydrolysis time and a higher percentage of blood result in higher digestibility values. Mathematics models can be used to estimate the protein content and digestibility value of HFM with coagulated blood. Hydrolyzed feather meal with higher protein content and digestibility value can be produced by adding coagulated blood and appropriate processing parameters. (HFM % (% kgf.cm−2, kgfcm2 kgfcm kgf.cm−2 , kgf cm 2 (kgf.cm−2) min, min (min) process values parameters ( kgf.cm− (kgf.cm−2 (min kgf.cm (kgf.cm− (kgf.cm

https://doi.org/10.37496/rbz5320220108

10.

Posicionamento do Departamento de Imagem Cardiovascular da Sociedade Brasileira de Cardiologia sobre o Uso do Strain Miocárdico na Rotina do Cardiologista – 2023 202 20 2
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Almeida, André Luiz Cerqueira

; Melo, Marcelo Dantas Tavares de

; Bihan, David Costa de Souza Le

; Vieira, Marcelo Luiz Campos

; Pena, José Luiz Barros

; Del Castillo, José Maria

; Abensur, Henry

; Hortegal, Renato de Aguiar

; Otto, Maria Estefania Bosco

; Piveta, Rafael Bonafim

; Dantas, Maria Rosa

; Assef, Jorge Eduardo

; Beck, Adenalva Lima de Souza

; Santo, Thais Harada Campos Espirito

; Silva, Tonnison de Oliveira

; Salemi, Vera Maria Cury

; Rocon, Camila

; Lima, Márcio Silva Miguel

; Barberato, Silvio Henrique

; Rodrigues, Ana Clara

; Rabschkowisky, Arnaldo

; Frota, Daniela do Carmo Rassi

; Gripp, Eliza de Almeida

; Barretto, Rodrigo Bellio de Mattos

; Silva, Sandra Marques e

; Cauduro, Sanderson Antonio

; Pinheiro, Aurélio Carvalho

; Araujo, Salustiano Pereira de

; Tressino, Cintia Galhardo

; Silva, Carlos Eduardo Suaide

; Monaco, Claudia Gianini

; Paiva, Marcelo Goulart

; Fisher, Cláudio Henrique

; Alves, Marco Stephan Lofrano

; Grau, Cláudia R. Pinheiro de Castro

; Santos, Maria Veronica Camara dos

; Guimarães, Isabel Cristina Britto

; Morhy, Samira Saady

; Leal, Gabriela Nunes

; Soares, Andressa Mussi

; Cruz, Cecilia Beatriz Bittencourt Viana

; Guimarães Filho, Fabio Villaça

; Assunção, Bruna Morhy Borges Leal

; Fernandes, Rafael Modesto

; Saraiva, Roberto Magalhães

; Tsutsui, Jeane Mike

; Soares, Fábio Luis de Jesus

; Falcão, Sandra Nívea dos Reis Saraiva

; Hotta, Viviane Tiemi

; Armstrong, Anderson da Costa

; Hygidio, Daniel de Andrade

; Miglioranza, Marcelo Haertel

; Camarozano, Ana Cristina

; Lopes, Marly Maria Uellendahl

; Cerci, Rodrigo Julio

; Siqueira, Maria Eduarda Menezes de

; Torreão, Jorge Andion

; Rochitte, Carlos Eduardo

; Felix, Alex

Arquivos Brasileiros de Cardiologia

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Dez 2023, Volume 120 Nº 12 elocation e20230646

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230646

11.

First reported cases of SARS-CoV-2 infection in owned dogs in Belo Horizonte, Brazil SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Horizonte SARS-CoV
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Silva Filho, A.P.

; Kmetiuk, L.B.

; Bicalho, G.C.

; Castillo, A.P.

; Soares, L.F.

; Vasconcelos, P.

; Santos, A.P.S.

; Carvalho, O.V.

; Reis, J. K. P.

; Silveira, J.A.G.

; Araujo, R. N.

; Aguiar, R.S.

; Brandespim, D. F.

; Pettan-Brewer, C.

; Biondo, A.W.

; Barbosa, D.S.

Arquivo Brasileiro de Medicina Veterinária e Zootecnia

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Jun 2023, Volume 75 Nº 3 Páginas 531 - 534

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/1678-4162-12890

12.

Enhanced Larvicidal Activity of New 1,2,4-Oxadiazoles against Aedes aegypti Mosquitos: QSAR and Docking Studies 1,2,4Oxadiazoles 124Oxadiazoles Oxadiazoles 1,2,4 1 2 4 Mosquitos 4Oxadiazoles 124 1,2, 12 1,2 1,
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Silva, Aluízio G. da

; Navarro, Daniela Maria A. F.

; Santos, Geanne K. N.

; Aguiar, Júlio César R. O. F. de

; França, Karla A. de

; Tébéka, Iris Raquel M.

; Anjos, Janaína V. dos

; Silva, João Bosco P. da

; Kanis, Luiz A.

; Srivastava, Rajendra M.

; Neves Filho, Ricardo Antônio W.

; Ramos, Mozart N.

Journal of the Brazilian Chemical Society

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Mar 2023, Volume 34 Nº 3 Páginas 333 - 345

Resumo: En | Texto: En | PDF: En

The worldwide emergence of viral diseases such as Zika, Dengue, Chikungunya, West Nile and Yellow Fever urge the search for solutions to eliminate their common vector, the Aedes aegypti mosquito. This paper describes the quantitative structure-activity relationship (QSAR) and docking studies of a series of nine 3-(3-aryl-1,2,4-oxadiazol-5-yl)propionic acids (AOPA), 1-9, previously published by our group. Additionally, three new 1,2,4-oxadiazoles, 10-12, have also been synthesized, characterized and studied. The QSAR and docking studies of all compounds, 1-12, clearly indicate that larger hydrophobic substituents such as biphenyl groups attached on position 3 in 1,2,4-oxadiazoles improve the larvicidal activity. It is worthwhile to mention that nanocapsulation of compounds 10-12 were necessary to help their dissolution in water and these three new 1,2,4-oxadiazoles also exhibited approximately equal or higher larvicidal activities compared to the former prototypes at stage L4. Zika Dengue Chikungunya vector mosquito structureactivity structure activity (QSAR 33aryl1,2,4oxadiazol5ylpropionic 33aryl124oxadiazol5ylpropionic aryloxadiazolylpropionic aryl 1,2,4 oxadiazol 5 yl propionic 1 2 4 AOPA, AOPA , (AOPA) 19, 19 9, 9 1-9 group Additionally 1,2,4oxadiazoles, 124oxadiazoles oxadiazoles oxadiazoles, 1012, 1012 10 12, 12 synthesized studied 112, 112 1-12 1,2,4oxadiazoles 10-1 L4 L 33aryl1 4oxadiazol5ylpropionic ylpropionic 124 1,2, (AOPA 1- 4oxadiazoles 101 11 1-1 10- 33aryl oxadiazolylpropionic 1,2 1,

https://doi.org/10.21577/0103-5053.20220112

13.

Demonstrações simples de desigualdades de Bell
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Machado, Rodrigo R.

; Aguiar, Carlos Eduardo

Revista Brasileira de Ensino de Física

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2023, Volume 45 elocation e20220324

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

A desigualdade de Bell expôs um dos aspectos mais fundamentais da mecânica quântica: a teoria é incompatível com a forma usual de se interpretar conceitos básicos como realidade e localidade. Embora o argumento original de Bell não seja de difícil compreensão, existem maneiras mais acessíveis de demonstrar desigualdades similares. Neste artigo apresentamos duas dessas demonstrações, propostas por Nick Herbert e Asher Peres, ambas muito simples e, ao que parece, relativamente pouco conhecidas apesar de seu interesse pedagógico. Também discutimos como a localidade e elementos de realidade descritos por variáveis ocultas se manifestam nessas demonstrações. quântica compreensão similares demonstrações Peres parece pedagógico

Bell’s inequality exposed one of the most fundamental aspects of quantum mechanics: the theory is incompatible with the usual way of interpreting basic concepts such as reality and locality. Although Bell’s original argument is not difficult to follow, there are more accessible ways to demonstrate similar inequalities. In this article we present two of these proofs, proposed by Nick Herbert and Asher Peres, both very simple and, it seems, relatively little known despite their pedagogical interest. We also discuss how locality and elements of reality described by hidden variables are introduced in these proofs. Bells Bell s mechanics follow inequalities proofs Peres seems interest

https://doi.org/10.1590/1806-9126-rbef-2022-0324

14.

First molecular description of autochthonous urban cases of canine visceral leishmaniasis in the city of Belém, Pará, Brazil Belém Pará
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Galvão, G. R.

; Gonçalves, E. C.

; Moura, L. G. S.

; Virgolino, R. R.

; Neves, A. M. P.

; Aguiar, D. C. F.

Brazilian Journal of Biology

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2023, Volume 83 elocation e267617

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A leishmaniose é uma antropozoonose transmitida por vetores, sendo os cães os principais reservatórios domésticos. O Brasil é um dos países mais acometidos por esta doença, sendo descrita em humanos e cães em todas as regiões do país. Na região norte casos de leishmaniose em humanos foram descritos em mais de 100 municípios do Estado, incluindo a capital, Belém. Este estudo envolve dois casos de leishmaniose visceral canina em que os animais desenvolveram sinais clínicos compatíveis com a doença em áreas urbanas de Belém, capital do estado do Pará. O diagnóstico foi confirmado pela reação em cadeia da polimerase (PCR) para detectar o SSUr-rDNA e kDNA de Leishmania sp e Leishmania infantum, respectivamente. Em um dos casos o animal veio a óbito e no outro o animal foi submetido a tratamento com medicamentos prescritos para cães. Por meio desse tratamento, a parasitemia no segundo animal foi mantida sob controle e está sendo monitorada por meio de testes moleculares. Anteriormente, nenhum caso canino havia sido notificado em bairros urbanos da cidade de Belém, apenas na ilha de Cotijuba, distante 29 quilômetros da cidade. Casos de leishmaniose canina e humana foram registrados próximo à capital, Belém, que possui áreas de vegetação conservada e onde foi descrita a presença de vetores de doenças. Assim, como tem sido registrado em várias outras cidades brasileiras, este estudo utiliza achados clínicos e laboratoriais para confirmar a presença de casos autóctones de leishmaniose visceral canina na cidade de Belém. domésticos país 10 Estado Belém Pará PCR (PCR SSUrrDNA SSUr rDNA infantum respectivamente moleculares Anteriormente Cotijuba 2 doenças Assim brasileiras 1

Abstract Leishmaniasis is an anthropozoonosis transmitted by vectors, with dogs being the main domestic reservoirs. Brazil is one of the countries most affected by this disease, and it has been described in humans and dogs in every region in the country. In the northern region leishmaniasis cases in humans have been described in more than 100 municipalities in the State, including the capital, Belém. This study involves two cases of canine visceral leishmaniasis in which the animals developed clinical signs compatible with the disease in urban areas in Belém, the Pará state capital. The diagnosis was confirmed via polymerase chain reaction (PCR) to detect SSUr-rDNA and kDNA of Leishmania sp. and Leishmania infantum, respectively. In one of the cases the animal died and in the other the animal underwent treatment with medicines prescribed for dogs. Through this treatment, parasitemia in the second animal has been kept under control and is being monitored through molecular tests. Previously, no canine cases had been notified from urban neighborhoods in the city of Belém, but only on the island of Cotijuba, at a distance of 29 kilometers from the city. Cases of canine and human leishmaniasis have been recorded close to the capital, Belém, which has areas of conserved vegetation and where the presence of disease vectors has been described. Thus, as has been done in several other Brazilian cities, this study uses clinical and laboratory findings to confirm the presence of autochthonous cases of canine visceral leishmaniasis in the city of Belém. reservoirs country 10 State capital Belém PCR (PCR SSUrrDNA SSUr rDNA sp infantum respectively tests Previously Cotijuba 2 Thus cities 1

https://doi.org/10.1590/1519-6984.267617

15.

Commercial characteristics of coffee seedlings produced with different sources of phosphorus and plant growth-promoting bacteria growthpromoting growth promoting
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Ferraro, A. C.

; França, A. C.

; Machado, C. M. M.

; Aguiar, F. R.

; Oliveira, L. L.

; Braga Neto, A. M

; Oliveira, R. G.

Brazilian Journal of Biology

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2023, Volume 83 elocation e270262

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Considerado o motor econômico de muitos países, a cultura do café representa um importante componente da cadeia agrícola no Brasil. Os crescentes valores de comercialização, das áreas de plantio e da produtividade da cultura requerem aquisição de mudas de qualidade, que devem receber adequado aporte nutricional através do uso eficiente de fertilizantes. Fertilizantes de liberação lenta e controlada, a exemplo dos organominerais, ganham destaque quando se trata de aumento da eficiência no uso do fósforo, assim como as bactérias promotoras de crescimento de plantas (BPCP) com características solubilizadoras de fosfato. Esse estudo teve como objetivo avaliar o efeito de diferentes fontes de fertilizantes mineral e organomineral, inoculados e não inoculados com BPCP, sobre parâmetros de qualidade de mudas de café. De forma geral, as fontes de P utilizadas no experimento interferiram positivamente no desenvolvimento das mudas de café. Isso comprova que existe a necessidade de complementação nutricional para um bom desenvolvimento das mudas. Dentre as fontes utilizadas, o organomineral na forma granulada apresentou melhor desempenho nos parâmetros de crescimento e fisiológicos das mudas de café, mostrando ser uma alternativa viável aos fertilizantes comumente utilizados. A adição de BPCP apresentou vantagem significativa para as variáveis de qualidade das mudas. países Brasil comercialização controlada organominerais fósforo (BPCP fosfato geral utilizados

Abstract Considered the economic engine of many countries, the coffee culture represents an important component of the agricultural chain in Brazil. The growing values of commercialization, planting areas, and crop productivity require the acquisition of quality seedlings, which must receive adequate nutritional support through efficient fertilizers. Slow and controlled-release fertilizers, such as organominerals, gain prominence when it comes to increasing efficiency in the use of phosphorus, as well as plant growth-promoting bacteria (PGPB) with phosphate solubilizing characteristics. This study aimed to evaluate the effect of different sources of mineral and organomineral fertilizers, inoculated and non-inoculated with PGPB on the quality parameters of coffee seedlings. In general, the P sources used in the experiment positively interfered with the development of coffee seedlings. This proves that there is a need for nutritional supplementation for the good development of the seedlings. Among the sources used, the organomineral in granulated form showed better performance in coffee seedlings' growth and physiological parameters, proving to be a viable alternative to commonly used fertilizers. The addition of PGPB showed a significant advantage for seedling quality variables. countries Brazil commercialization areas seedlings fertilizers controlledrelease controlled release organominerals phosphorus growthpromoting promoting (PGPB characteristics noninoculated non general variables

https://doi.org/10.1590/1519-6984.270262

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