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Mast cells in oral lichen planus and oral lichenoid lesions related to dental amalgam contact
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NORONHA, Mariana Saturnino de

; SOUTO, Giovanna Ribeiro

; FELIX, Fernanda Aragão

; ABREU, Lucas Guimarães

; AGUIAR, Maria Cássia Ferreira

; MENDONÇA, Elismauro Francisco

; MESQUITA, Ricardo Alves

Brazilian Oral Research

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2024, Volume 38 elocation e005

Resumo: En | Texto: En | PDF: En

Abstract The aim of this study was to analyze the expression of mast cell markers toluidine blue, c-kit, and tryptase and presence of mononuclear inflammatory cells in oral lichen planus (OLP) and oral lichenoid lesions related to dental amalgam. Nineteen specimens of OLP, OLLC, and healthy oral mucosa were selected. Mononuclear inflammatory cells were analyzed. Histochemical and immunohistochemical analyses were performed using toluidine blue, anti-c-kit and anti-tryptase reagents, and the results were quantified in areas A and B of connective tissue. Mast cells of all OLP and OLLC samples were positive for toluidine blue, c-kit, and tryptase. The density of toluidine blue+, c-kit+ and tryptase+ mast cells was higher in tissue with OLP and OLLC compared with healthy controls (p < 0.05). No difference was noted in mast cells density between OLP and OLLC (p > 0.05). The density of tryptase+ mast cells was higher in the subepithelial region (area A) than the region below it (Area B) in OLLC (p = 0.047). The mononuclear inflammatory cell density was higher in OLLC compared to OLP, but without statistical significance (p > 0.05). A positive statistical correlation was found between mononuclear immune cells and density of c-kit+ and tryptase+ mast cells in OLP (r = 0.943 and r = 0.886, respectively). Our data demonstrate that the etiopathogenesis process of OLP and OLLC modulates the expansion and degranulation of mast cells; mast cells density, however, was similar between OLP and OLLC. The distribution of mast cells appears to vary along the lamina propria. blue ckit, ckit c kit, kit c-kit (OLP amalgam selected analyzed antickit anti antitryptase reagents blue+ ckit+ kit+ p 0.05. 005 0.05 . 0 05 0.05) area Area 0.047. 0047 0.047 047 0.047) 0943 943 0.94 0886 886 0.886 respectively. respectively respectively) however propria 00 0.0 004 0.04 04 094 94 0.9 088 88 0.88 0. 09 9 08 8 0.8

https://doi.org/10.1590/1807-3107bor-2024.vol38.0005

EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features EZH
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NORONHA, Mariana Saturnino de

; VIANA, Karolina Skarlet Silva

; AGUIAR, Maria Cássia Ferreira de

; SQUARIZE, Cristiane Helena

; ABREU, Mauro Henrique Nogueira Guimarães de

; MENDONÇA, Elismauro Francisco

; BERNARDES, Vanessa de Fátima

Brazilian Oral Research

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2024, Volume 38 elocation e018

Resumo: En | Texto: En | PDF: En

Abstract The aim of this study was to evaluate the expression of the EZH2 protein and describe the clinical and microscopic characteristics of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA). The study included 16 ACC cases and 12 PA. All ACC and PA cases were positive for EZH2 and the ACC samples showed significantly higher EZH2 expression. The clinical and microscopic covariates were described in relation to EZH2 staining in ACC samples. The highest mean values of EZH2 were observed in cases with local metastasis, recurrence, perineural invasion, and predominantly cribriform growth pattern without solid areas. EZH2 is a potential marker of malignancy. EZH (ACC . (PA) 1 metastasis recurrence invasion areas malignancy (PA

https://doi.org/10.1590/1807-3107bor-2024.vol38.0018

Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma XIIIa
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Flores, Isadora Luana

; de Arruda, José Alcides Almeida

; Abrantes, Thamiris de Castro

; Gamba, Thiago de Oliveira

; Abrahão, Aline Correa

; Anbinder, Ana Lia

; Ribeiro, Jaqueline Lemes

; Vasconcelos, Ana Carolina Uchoa

; Andrade, Bruno Augusto Benevenuto de

; Aguiar, Maria Cassia Ferreira de

; Gomes, Ana Paula Neutzling

; Abreu, Lucas Guimarães

; Mesquita, Ricardo Alves

Brazilian Oral Research

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2024, Volume 38 elocation e113

Resumo: En | Texto: En | PDF: En

Abstract There is an interaction between dendrocytes and mast cells in the skin. However, in elastosis-related diseases such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), this interaction remains unknown. We investigated the presence of intact and degranulated mast cells in AC and LLSCC. Associations of mast cells with factor XIIIa+ dendrocytes and inflammatory infiltrate were assessed. Forty cases of AC (20 with low-grade and 20 with high-grade epithelial dysplasia), 50 cases of LLSCC, and 10 cases of normal oral mucosa were evaluated. Toluidine blue staining was performed to identify mast cells, and mast cell densities were calculated in the inflammatory infiltrate. Factor XIIIa+ dendrocytes were immunohistochemically quantified. The highest ratio of intact/degranulated mast cells density was detected in LLSCC (5.9 cells/mm2), followed by AC with high-grade epithelial dysplasia (4.8 cells/mm2). Statistically significant differences were found in the density of intact mast cells compared to degranulated mast cells in AC with low-grade epithelial dysplasia (p<0.001), AC with high-grade epithelial dysplasia (p=0.005), and LLSCC (p<0.001). A positive correlation between degranulated mast cells and total inflammatory infiltrate (p=0.03) was observed in the LLSCC group. The expression of factor XIIIa+ dendrocytes was highest in AC with low-grade epithelial dysplasia (16.5 cells/mm2). The link between mast cell density, factor XIIIa+ dendrocytes, and inflammatory infiltrate indicates a potential crosstalk in lip carcinogenesis. skin However elastosisrelated elastosis related (AC , (LLSCC) unknown XIIIa assessed (2 lowgrade low grade 2 highgrade high dysplasia, dysplasia) 5 1 evaluated quantified intactdegranulated 5.9 59 9 (5. cells/mm2, cellsmm2 cellsmm cells/mm2 mm2 mm cells/mm2) 4.8 48 4 8 (4. cells/mm2. . p<0.001, p0001 p p<0.001 0 001 (p<0.001) p=0.005, p0005 p=0.005 005 (p=0.005) p<0.001. p=0.03 p003 03 (p=0.03 group 16.5 165 16 (16. carcinogenesis (LLSCC ( 5. (5 cells/mm 4. (4 p000 p<0.00 00 (p<0.001 p=0.00 (p=0.005 p=0.0 p00 (p=0.0 16. (16 p<0.0 (p<0.00 (p=0.00 p=0. p0 (p=0. (1 p<0. (p<0.0 p=0 (p=0 p<0 (p<0. p= (p= p< (p<0 (p (p<

https://doi.org/10.1590/1807-3107bor-2024.vol38.0113

Effects of tobacco on the DNA of smokers and non-smokers affected by OSCC: systematic review and meta-analysis nonsmokers non OSCC metaanalysis meta analysis
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SCHUCH, Lauren Frenzel

; VIANA, Karolina Skarlet Silva

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; AGUIAR, Maria Cássia Ferreira de

; BERNARDES, Vanessa Fátima

Brazilian Oral Research

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2023, Volume 37 elocation e008

Resumo: En | Texto: En | PDF: En

Abstract Scientific evidence about genetic and molecular changes in oral squamous cell carcinoma (OSCC) among smokers and non-smokers is inconclusive. This systematic review and meta-analysis assessed the effects of tobacco on the DNA of individuals with OSCC based on protein mutations. Electronic searches were conducted on PubMed, Ovid, Web of Science, and Scopus to identify observational studies published up to January/2022. The Joanna Briggs Institute tool was used for the critical appraisal of studies. The certainty of the evidence was evaluated. Twenty-three studies assessing 4,060 individuals (2,967 smokers vs. 1,093 non-smokers) were included in this review. Fifteen groups of proteins/genes were investigated. Analysis of the quality of articles revealed low risk of bias in most studies. The certainty of the evidence was very low. The meta-analysis confirmed no significant difference between smokers and non-smokers with respect to damage to GSTM1 (OR: 0.60; 95%CI: 0.30–1.18), GSTT1 (OR: 1.18; 95%CI:0.49–2.83), hydrolase proteins (Ku70 and Ku80) (OR: 0.74; 95%CI: 0.18–3.05), and transferase proteins (GSTM1, GSTT1, GSTM3) (OR: 0.74; 95%CI: 0.47–1.18). Most of the studies included showed that smokers are more likely to exhibit genetic instability. However, the meta-analysis revealed that smokers do not necessarily have more genetic alterations in the DNA than non-smokers. (OSCC nonsmokers non inconclusive metaanalysis meta analysis mutations PubMed Ovid Science January2022 January 2022 January/2022 evaluated Twentythree Twenty three 4060 4 060 4,06 2,967 2967 2 967 (2,96 vs 1093 1 093 1,09 proteinsgenes genes investigated GSTM OR (OR 0.60 0 60 95%CI 95CI CI 95 0.30–1.18, 030118 0.30–1.18 , 30 18 0.30–1.18) GSTT 1.18 118 95%CI0.49–2.83, 95CI049283 0.49–2.83 49 83 95%CI:0.49–2.83) Ku70 Ku (Ku7 Ku80 0.74 074 74 0.18–3.05, 018305 0.18–3.05 3 05 0.18–3.05) GSTM1, (GSTM1 GSTM3 0.47–1.18. 047118 0.47–1.18 . 47 0.47–1.18) instability However nonsmokers. smokers. January202 202 January/202 406 06 4,0 2,96 296 96 (2,9 109 09 1,0 0.6 6 9 03011 0.30–1.1 1.1 11 CI0 95%CI0.49–2.83 95CI04928 049283 0.49–2.8 8 95%CI:0.49–2.83 Ku7 (Ku Ku8 0.7 07 7 01830 0.18–3.0 (GSTM 04711 0.47–1.1 January20 20 January/20 40 4, 2,9 29 (2, 10 1, 0. 0301 0.30–1. 1. 95%CI0.49–2.8 95CI0492 04928 0.49–2. 95%CI:0.49–2.8 0183 0.18–3. 0471 0.47–1. January2 January/2 2, (2 030 0.30–1 95%CI0.49–2. 95CI049 0492 0.49–2 95%CI:0.49–2. 018 0.18–3 047 0.47–1 January/ ( 03 0.30– 95%CI0.49–2 95CI04 049 0.49– 95%CI:0.49–2 01 0.18– 04 0.47– 0.30 95%CI0.49– 95CI0 0.49 95%CI:0.49– 0.18 0.47 0.3 95%CI0.49 0.4 95%CI:0.49 0.1 95%CI0.4 95%CI:0.4 95%CI0. 95%CI:0. 95%CI0 95%CI:0

https://doi.org/10.1590/1807-3107bor-2023.vol37.0008

ARTIFICIAL HYBRIDIZATION WITHOUT EMASCULATION IN LIMA BEAN (Phaseolus lunatus L.)
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SOUSA, ANTÔNIA MARIA DE CASSIA BATISTA DE

; SILVA, VERÔNICA BRITO DA

; SILVESTRE, ELLIDA DE AGUIAR

; SILVA, RAIMUNDO NONATO OLIVEIRA

; LOPES, ANGELA CELIS DE ALMEIDA

; GOMES, REGINA LUCIA FERREIRA

Revista Caatinga

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Mar 2022, Volume 35 Nº 1 Páginas 223 - 230

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Este estudo teve como objetivo validar a hibridação artificial sem emasculação em feijão-fava, identificando a geração de F1 utilizando marcadores de microssatélites (SSR). Foram utilizados quatro genótipos do Banco Ativo de Germoplasma de Phaseolus da Universidade Federal do Piauí (BGP-UFPI), com hábitos de crescimento e maturidade contrastantes. Os 241 cruzamentos realizados apresentaram percentual de vagens híbridas de 5,8%, obtendo 42 sementes na F1. O cruzamento artificial foi confirmado pelos marcadores microsatélites (BM 211, BM 141, BM 154 e GAT 591), e quatro plantas foram identificadas como híbridas. Assim, o método proposto é eficaz na realização de cruzamentos artificiais em feijões-fava.

ABSTRACT This study aimed to validate the artificial hybridization without emasculation in lima beans, identifying F1 generation using microsatellite markers (SSR). We used four accessions from the Active Germplasm Bank of Phaseolus, Universidade Federal do Piauí (BGP-UFPI), with contrasting growth habits and days-to-maturity traits. The 241 crosses performed had a percentage of hybrid pods of 5.8%, obtaining 42 seeds in F1. Artificial cross-fertilization was confirmed by microsatellite markers (BM 211, BM 141, BM 154, and GAT 591), and four plants were identified as hybrids. Thus, the proposed method is effective in performing artificial crosses for lima beans.

https://doi.org/10.1590/1983-21252022v35n123rc

DNA damage-related proteins in smokers and non-smokers with oral cancer
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Schuch, Lauren Frenzel

; de Arruda, José Alcides Almeida

; Viana, Karolina Skarlet Silva

; Caldeira, Patrícia Carlos

; Abreu, Mauro Henrique Nogueira Guimarães

; Bernardes, Vanessa Fátima

; Aguiar, Maria Cássia Ferreira de

Brazilian Oral Research

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2022, Volume 36 elocation e027

Resumo: En | Texto: En | PDF: En

Abstract: Tobacco smoking involves a high risk of human malignancies, including oral cancer, because it contains multiple carcinogens that cause genetic instability. Thus, a worse prognosis would be expected for cancer patients who are smokers. The aim of this study was to assess the DNA damage response through the expression of checkpoint kinase 2 (CHK2), H2A histone family member X (H2AX), and P53 among smokers and non-smokers with oral squamous cell carcinoma (OSCC). Associations between immunoexpression of proteins and clinicopathological data and histopathological grading were also analyzed. A total of 35 individuals (18 non-smokers and 17 smokers) with OSCC of the tongue and/or floor of the mouth were included. Immunohistochemistry for H2AX was conducted for the identification of double-strand breaks, CHK2, and P53 to evaluate the expression of this protein in cell cycle regulation. The sample consisted of 22 males and 13 females, with a mean age of 63.9±11.8 years. OSCC of non-smokers were well-differentiated tumors in 50% of the cases, and those of smokers were equally distributed into moderately differentiated and poorly differentiated tumors (35.3% each). Overall, 31 (88.6%) cases were CHK2-positive, 27 (77.1%) were H2AX-positive, and 23 (65.7%) were P53-positive, with no difference between smokers and non-smokers (p > 0.05). No association was found between proteins and clinicopathologic data (p > 0.05). Similarities in CHK2, H2AX, and P53 immunohistochemical staining patterns were observed between smokers and non-smokers, and immunoexpression was not associated with clinicopathological parameters. However, the findings indicated consistent expression of these proteins in OSCC.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0027

Salivary molecules of bone remodeling and tissue repair after head and neck radiotherapy
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OLIVEIRA, Eduardo Morato de

; GUIEIRO, Rafael Soares

; CRUZ, Bárbara Lima

; AGUIAR, Maria Cássia Ferreira de

; SILVA, Janine Mayra da

; SILVA, Tarcília Aparecida

; CALDEIRA, Patrícia Carlos

Brazilian Oral Research

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2021, Volume 35 elocation e079

Resumo: En | Texto: En | PDF: En

Abstract Head and neck radiotherapy causes quantitative and qualitative changes in saliva. The objective of this case-control study was to evaluate the salivary biomarkers associated with bone remodeling and tissue repair in patients submitted to radiotherapy for head and neck cancer treatment, compared with non-irradiated individuals. Total unstimulated saliva was collected for ELISA assay analysis of receptor activator for nuclear factor κ B (RANK) and its ligand (RANK-L), osteoprotegerin, matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-2, vascular endothelial growth factor, and epidermal growth factor. Statistics were performed, and revealed that salivary RANK (p = 0.0304), RANK-L (p = 0.0005), matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-2 (p = 0.0067), vascular endothelial growth factor (p = 0.0060), and epidermal growth factor (p < 0.0001) were reduced in patients, compared with the control group. Osteoprotegerin did not differ between the groups (p = 0.3765). Salivary biomarkers did not differ according to radiotherapy completion time (p > 0.05). In conclusion, the lower output of the salivary molecules – essential for bone remodeling and tissue repair – may disrupt tissue homeostasis and play a role in the pathogenesis of the radiotherapy-induced deleterious effects in the oral cavity.

https://doi.org/10.1590/1807-3107bor-2021.vol35.0079 150 downloads

The Program for Biodiversity Research in Brazil: The role of regional networks for biodiversity knowledge, dissemination, and conservation
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ROSA, CLARISSA

; BACCARO, FABRICIO

; CRONEMBERGER, CECILIA

; HIPÓLITO, JULIANA

; BARROS, CLAUDIA FRANCA

; RODRIGUES, DOMINGOS DE JESUS

; NECKEL-OLIVEIRA, SELVINO

; OVERBECK, GERHARD E.

; DRECHSLER-SANTOS, ELISANDRO RICARDO

; ANJOS, MARCELO RODRIGUES DOS

; FERREGUETTI, ÁTILLA C.

; AKAMA, ALBERTO

; MARTINS, MARLÚCIA BONIFÁCIO

; TOMAS, WALFRIDO MORAES

; SANTOS, SANDRA APARECIDA

; FERREIRA, VANDA LÚCIA

; CUNHA, CATIA NUNES DA

; PENHA, JERRY

; PINHO, JOÃO BATISTA DE

; SALIS, SUZANA MARIA

; DORIA, CAROLINA RODRIGUES DA COSTA

; PILLAR, VALÉRIO D.

; PODGAISKI, LUCIANA R.

; MENIN, MARCELO

; BÍGIO, NARCÍSIO COSTA

; ARAGÓN, SUSAN

; MANZATTO, ANGELO GILBERTO

; VÉLEZ-MARTIN, EDUARDO

; SILVA, ANA CAROLINA BORGES LINS E

; IZZO, THIAGO JUNQUEIRA

; MORTATI, AMANDA FREDERICO

; GIACOMIN, LEANDRO LACERDA

; ALMEIDA, THAÍS ELIAS

; ANDRÉ, THIAGO

; SILVEIRA, MARIA AUREA PINHEIRO DE ALMEIDA

; SILVEIRA, ANTÔNIO LAFFAYETE PIRES DA

; MESSIAS, MARILUCE REZENDE

; MARQUES, MARCIA C.M.

; PADIAL, ANDRE ANDRIAN

; MARQUES, RENATO

; BITAR, YOUSZEF O.C.

; SILVEIRA, MARCOS

; MORATO, ELDER FERREIRA

; PAGOTTO, RUBIANI DE CÁSSIA

; STRUSSMANN, CHRISTINE

; MACHADO, RICARDO BOMFIM

; AGUIAR, LUDMILLA MOURA DE SOUZA

; FERNANDES, GERALDO WILSON

; OKI, YUMI

; NOVAIS, SAMUEL

; FERREIRA, GUILHERME BRAGA

; BARBOSA, FLÁVIA RODRIGUES

; OCHOA, ANA C.

; MANGIONE, ANTONIO M.

; GATICA, AILIN

; CARRIZO, MARÍA CELINA

; RETTA, LUCÍA MARTINEZ

; JOFRÉ, LAURA E.

; CASTILLO, LUCIANA L.

; NEME, ANDREA M.

; RUEDA, CARLA

; TOLEDO, JOSÉ JULIO DE

; GRELLE, CARLOS EDUARDO VIVEIROS

; VALE, MARIANA M.

; VIEIRA, MARCUS VINICIUS

; CERQUEIRA, RUI

; HIGASHIKAWA, EMÍLIO MANABU

; MENDONÇA, FERNANDO PEREIRA DE

; GUERREIRO, QUÊZIA LEANDRO DE MOURA

; BANHOS, AUREO

; HERO, JEAN-MARC

; KOBLITZ, RODRIGO

; COLLEVATTI, ROSANE GARCIA

; SILVEIRA, LUÍS FÁBIO

; VASCONCELOS, HERALDO L.

; VIEIRA, CECÍLIA RODRIGUES

; COLLI, GUARINO RINALDI

; CECHIN, SONIA ZANINI

; SANTOS, TIAGO GOMES DOS

; FONTANA, CARLA S.

; JARENKOW, JOÃO A.

; MALABARBA, LUIZ R.

; RUEDA, MARTA P.

; ARAUJO, PUBLIO A.

; PALOMO, LUCAS

; ITURRE, MARTA C.

; BERGALLO, HELENA GODOY

; MAGNUSSON, WILLIAM E.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 Nº 2 elocation e20201604

Resumo: En | Texto: En | PDF: En

Abstract The Program for Biodiversity Research (PPBio) is an innovative program designed to integrate all biodiversity research stakeholders. Operating since 2004, it has installed long-term ecological research sites throughout Brazil and its logic has been applied in some other southern-hemisphere countries. The program supports all aspects of research necessary to understand biodiversity and the processes that affect it. There are presently 161 sampling sites (see some of them at Supplementary Appendix), most of which use a standardized methodology that allows comparisons across biomes and through time. To date, there are about 1200 publications associated with PPBio that cover topics ranging from natural history to genetics and species distributions. Most of the field data and metadata are available through PPBio web sites or DataONE. Metadata is available for researchers that intend to explore the different faces of Brazilian biodiversity spatio-temporal variation, as well as for managers intending to improve conservation strategies. The Program also fostered, directly and indirectly, local technical capacity building, and supported the training of hundreds of undergraduate and graduate students. The main challenge is maintaining the long-term funding necessary to understand biodiversity patterns and processes under pressure from global environmental changes.

https://doi.org/10.1590/0001-3765202120201604 1034 downloads

Chronic inflammatory periapical diseases: a Brazilian multicenter study of 10,381 cases and literature review
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COUTO, Aline Maria do

; MEIRELLES, Daniela Pereira

; VALERIANO, Alline Teixeira

; ALMEIDA, Douglas Silva de

; MORAES, Êmile de

; TARQUINIO, Sandra Beatriz Chaves

; BATISTA, Aline Carvalho

; MENDONÇA, Elismauro Francisco de

; COSTA, Nádia do Lago

; ALVES, Pollianna Muniz

; NONAKA, Cassiano Francisco Weege

; ABREU, Lucas Guimarães

; AGUIAR, Maria Cássia Ferreira de

Brazilian Oral Research

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2021, Volume 35 elocation e033

Resumo: En | Texto: En | PDF: En

Abstract The aim of this study was to investigate the epidemiological and clinical characteristics of chronic inflammatory periapical diseases in different regions of Brazil and to compare with data from the literature. A multicenter study was carried out in four Brazilian referral centers in oral diagnosis. Histopathological records were reviewed, and all cases diagnosed microscopically as periapical granuloma, radicular cyst, and periapical abscess were included. Demographic and clinical data were collected. Descriptive statistics and Pearson’s chi-square test were performed. A total of 10,381 cases of chronic inflammatory periapical diseases were found (13.8% of 74,931 archived specimens) over a period of 65 years. Radicular cysts were the most common lesion (59.9%). Women (56.1%) with a mean age of 37.01 years old (range 13 to 100 ± 14.42) and people of white skin color (59.2%) were the most affected individuals by chronic inflammatory periapical diseases. The lesions were generally asymptomatic (28.1%), located in the maxilla (60.1%), and posterior region (49.8%). The radicular cysts were larger when compared to periapical granulomas (p < 0.001). The disagreement between the clinical and histopathological diagnoses was higher when the final diagnosis was a periapical granuloma (p < 0.001). Chronic inflammatory periapical diseases continue to be common lesions affecting mainly adults. This should be a consequence of the burden of untreated caries in permanent teeth. Women are more affected and radicular cyst was the most common lesion.

https://doi.org/10.1590/1807-3107bor-2021.vol35.0033 767 downloads

10.

Diagnosing acquired syphilis through oral lesions: the 12 year experience of an Oral Medicine Center
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Matias, Michelle Danielle Porto

; Jesus, Alessandro Oliveira de

; Resende, Renata Gonçalves

; Caldeira, Patrícia Carlos

; Aguiar, Maria Cássia Ferreira de

Brazilian Journal of Otorhinolaryngology

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Jun 2020, Volume 86 Nº 3 Páginas 358 - 363

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução: Um ressurgimento da sífilis no Brasil tem sido relatado nos últimos anos. Objetivo: Investigar a frequência, as características demográficas e clínicas dos pacientes com sífilis adquirida com envolvimento oral que receberam atendimento médico em um centro de referência em medicina oral em um hospital público brasileiro. Método: Estudo retrospectivo, abrangeu 12 anos, feito para identificar tendências de mudança na sífilis. Registros médicos de todos os pacientes diagnosticados com sífilis adquirida que receberam atendimento médico na clínica de medicina oral do hospital de 2005 a 2016 foram revisados e os dados demográficos e clínicos foram coletados. Resultados: Foram diagnosticas 85 pacientes com sífilis adquirida, com um aumento significativo no número de casos nos últimos 5 anos. A idade dos pacientes variou de 16 a 76 anos, com pico na terceira e quarta décadas; 48 casos eram do sexo masculino (56,5%) e 37 do sexo feminino (43,5%). A maioria das lesões orais apareceu como úlceras ou placas únicas, os lábios e a língua representaram os locais mais afetados. Todos os casos foram positivos para Venereal Disease Research Laboratory e Fluorescent Treponemal Antibody Absorption Test e o tratamento foi feito com penicilina G benzatina na maioria dos casos (84,7%). Conclusão: A frequência da sífilis oral tem aumentado com o tempo e as lesões orais podem representar uma pista diagnóstica; portanto, os profissionais de saúde bucal devem ser conscientizados e devidamente treinados na tentativa de desenvolver um alto grau de suspeição clínica no diagnóstico da sífilis.

Abstract Introduction: A resurgence of syphilis in Brazil has been reported in recent years. Objective: With this in mind, the present study sought to investigate the frequency, demographics, and clinical characteristics of patients with acquired syphilis with oral involvement who received medical care at an Oral Medicine Reference Center in a Brazilian Public Hospital. Methods: A retrospective study, spanning a period of 12 years, was performed to identify changing trends in syphilis over time. Medical records from all patients diagnosed with acquired syphilis who received medical care at the Hospital's Oral Medicine Clinic from 2005 to 2016 were reviewed, and the demographic and clinical data were collected. Results: A total of 85 patients had been diagnosed with acquired syphilis, with a significant increase in the number of cases over the past 5 years. Patients ranged from 16 to 76 years of age, with a peak in the third and fourth decades. Forty-eight cases affected males (56.5%), while 37 cases affected females (43.5%). Most of the oral lesions appeared as unique ulcers or plaques, with the lips and tongue representing the most affected sites. All cases were positive for Venereal Disease Research Laboratory or Fluorescent Treponemal Antibody Absorption, and treatment was performed with Penicillin G benzathine in most cases (84.7%). Conclusion: The frequency of oral syphilis has been rising over time and oral lesions may well represent a diagnostic clue; therefore, oral health professionals must be made aware and properly trained in an attempt to develop a high degree of clinical suspicion in the diagnosis of syphilis.

https://doi.org/10.1016/j.bjorl.2018.12.010 1226 downloads

11.

Advanced carcinoma of the oropharynx: survival analysis comparing two treatment modalities
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CALDEIRA, Patrícia Carlos

; BONARDI, Mara Juliana Fagundes

; PANTUZZO, Esther Rodrigues Mansur

; SOARES, João Marcos Arantes

; SOTO, Andréa Maria Lopez

; AGUIAR, Maria Cássia Ferreira

; SOUSA, Alexandre Andrade

Brazilian Oral Research

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2020, Volume 34 elocation e032

Resumo: En | Texto: En | PDF: En

Abstract About 92,000 new cases of oropharynx carcinoma are expected to occur annually worldwide. There is no consensus about the best therapy for these advanced tumors. The objective of the present study was to evaluate overall and disease-free survival rates of patients with advanced oropharynx squamous cell carcinoma, comparing surgery + radiotherapy with chemotherapy + radiotherapy. Medical records of patients were reviewed. Previously treated tumors were excluded. Clinical, demographic and microscopic information was collected, and p16 staining was performed. Kaplan-Meier survival curves were plotted. Forty-seven cases were included, 41 men and 6 women, having a mean age of 56.3 years. Most patients were smokers (85.1%) and consumed alcohol (74.5%). Patients were stage III (21.3%) or IV (78.7%). Most lesions affected the base of the tongue (36.2%). Of the 23 cases available for p16 testing, 3 were positive (13.0%). There was no difference between the overall and the disease-free survival rates for the two treatment modalities (p>0.05), even when only resectable tumors were compared. Seventeen cases experienced recurrence (36.2%); 16 (34.0%) patients remained alive without disease; 15 (31.9%) died due to disease; 9 (19.2%) were recurrent at the last follow-up. The two treatment protocols were equally efficient in treating advanced oropharynx squamous cell carcinoma, since both promoted similar overall and disease-free survival rates. The results and interpretations related herein mostly regard “conventional” oropharyngeal squamous cell carcinomas, as opposed to HPV-associated tumors.

https://doi.org/10.1590/1807-3107bor-2020.vol34.0032 1038 downloads

12.

Cytokines and chemokines associated with Treg/Th17 response in chronic inflammatory periapical disease
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TOLEDO, André Oliveira Naufel de

; COUTO, Aline Maria do

; MADEIRA, Mila Fernandes Moreira

; CALDEIRA, Patrícia Carlos

; QUEIROZ-JUNIOR, Celso Martins

; AGUIAR, Maria Cássia Ferreira de

Brazilian Oral Research

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2019, Volume 33 elocation e093

Resumo: En | Texto: En | PDF: En

Abstract Cytokines and chemokines have a fundamental role in the maintenance of inflammation and bone response, which culminate in the development of chronic periapical lesions. Regulatory (Treg) and Th17 cytokines play a key role in regulating the immune response involved in this process. The aim of this study was to investigate the role of Treg and Th17 cells in chronic inflammatory periapical disease, by comparing the expression of the immunoregulatory mediators TGF-β, IL-10, CCL4, and the proinflammatory IL-17 and CCL20 in the periapical tissue of teeth with pulp necrosis, with and without associated chronic lesions. Eighty-six periapical tissue samples were obtained from human teeth. The samples were divided into three groups: pulp necrosis with a periapical lesion (n=26); pulp necrosis without a periapical lesion (n=30), and control (n=30). All samples were submitted to histopathological analysis and cytokine and chemokine measurement through ELISA. Statistical analyses were done with Kruskal-Wallis and Mann-Whitney tests and Spearman correlation. The group with pulp necrosis and a periapical lesion showed a higher expression of CCL4 and TGF-β in comparison with pulp necrosis without a lesion. CCL20 was higher in the group with a periapical lesion when compared to the control. In all groups there was a weak positive correlation between IL-17/CCL20, IL-10/CCL4, and IL-17/TGF-β. Both types of cytokines, pro-inflammatory and immunoregulatory, occur simultaneously in periapical tissue. However, a rise in immunosuppressive cytokines and chemokines (CCL4 and TGF-β) in periapical lesions suggests a role of these cytokines in stable periapical disease.

https://doi.org/10.1590/1807-3107bor-2019.vol33.0093 1170 downloads

13.

Treg and Th17 cells in inflammatory periapical disease: a systematic review
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Naufel, André Oliveira

; Aguiar, Maria Cássia Ferreira

; Madeira, Fernandes Moreira

; Abreu, Lucas Guimarães

Brazilian Oral Research

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2017, Volume 31 elocation e103

Resumo: En | Texto: En | PDF: En

Abstract: The process involved in periapical lesions, which occur as an outcome of pulpal necrosis, is regulated by the immune system including regulatory T cells (Treg) and T helper 17 cell (Th17) responses. The objective of this study was to conduct a frequency systematic review to determine the presence of Treg/Th17 responses and the influence of these cells in the progression of chronic inflammatory periapical lesions in humans. A systematic computerized search was carried out in Pubmed, Medline, Web of Science and Scopus electronic databases from their date of inception through the first week of May 2017. In addition, the reference lists of the included articles and the grey literature were hand-searched. Articles that evaluated the presence and influence of Treg/Th17 in the progression of human periapical lesions were included. Study selection and the quality assessment of the included articles (using the Newcastle-Ottawa scale) were carried out by two authors. Fifty-seven titles/abstracts were screened and eight studies met the eligibility criteria and were included in this systematic review. The included studies showed large variation in the type of periapical lesion assessed, mean age, age range, type of experiment and findings regarding the participation of Th17 and Treg in the status of inflammatory periapical lesions. The studies showed the involvement of Treg in the modulation of the inflammatory response in radicular cysts and periapical granulomas. This systematic review highlights the relationship between Treg and Th17 acting in a subtle balance inhibiting or promoting the progression of human periapical lesions.

https://doi.org/10.1590/1807-3107bor-2017.vol31.0103 2469 downloads

14.

Tumor-associated macrophages (TAMs): clinical-pathological parameters in squamous cell carcinomas of the lower lip
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LÚCIO, Priscilla Suassuna Carneiro

; RIBEIRO, Daniela Cotta

; AGUIAR, Maria Cássia Ferreira de

; ALVES, Pollianna Muniz

; NONAKA, Cassiano Francisco Weege

; GODOY, Gustavo Pina

Brazilian Oral Research

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2016, Volume 30 Nº 1 elocation e95

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to analyze the presence of tumor-associated macrophage (TAM) subpopulations M1 and M2 in squamous cell carcinoma of the lower lip (SCCLL) by immunohistochemitry, and to evaluate the possible role of these subtypes in the development of regional lymph node metastasis and their association with clinical and pathological parameters. Forty-two cases of SCCLL were divided into two groups (21 with and 21 without regional lymph node metastasis). The histopathological grade of malignancy was determined and the material was submitted to double staining with anti-CD68/anti-CD163 and anti-CD68/anti-HLA-DR monoclonal antibodies. The results were analyzed statistically using the Wilcoxon signed-rank and Spearman correlation tests. The M1 and M2 subpopulations were observed in all cases studied. No significant difference was observed between the quantities of M1 and M2 TAMs regarding tumor size (p > 0.05). A significantly larger number of M2 compared to M1 TAMs was observed in tumors without regional lymph node metastasis, tumors in early stages, and low-grade tumors (p < 0.05). No significant difference between the numbers of M1 and M2 TAMs was observed in tumors with regional lymph node metastasis, tumors in advanced stages, and high-grade tumors (p > 0.05). There was a positive weak correlation between M1 and M2 TAMs (r = 0.361; p = 0.019). The results suggest a more important role of M2 TAMs in early stages than advanced stages of lip carcinogenesis. The progression of SCCLL does not seem to be related to an imbalance of macrophage polarization in the microenvironment of these tumors.

https://doi.org/10.1590/1807-3107BOR-2016.vol30.0095 2111 downloads

15.

Immunohistochemical analysis of FoxP3+ regulatory T cells in lower lip squamous cell carcinomas
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da CUNHA FILHO, Fernando Antonio Portela

; AGUIAR, Maria Cássia Ferreira de

; SOUZA, Lélia Batista de

; PINTO, Leão PEREIRA

; GODOY, Gustavo Pina

; ALVES, Pollianna Muniz

; NONAKA, Cassiano Francisco Weege

Brazilian Oral Research

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2016, Volume 30 Nº 1 elocation e130

Resumo: En | Texto: En | PDF: En

Abstract: The aim of this study was to determine the number of FoxP3+ regulatory T (Treg) cells in the microenvironment of lower lip squamous cell carcinomas (LLSCCs) and to correlate the findings with clinicopathological parameters (tumor size/extent, regional lymph node metastasis, clinical stage, and histopathological grade of malignancy). Fifty cases of LLSCC were selected. Lymphocytes exhibiting nuclear immunostaining for FoxP3 were quantified in 10 microscopic fields at the deep invasive front of LLSCCs. The results were analyzed statistically using the nonparametric Mann-Whitney test and Fisher's exact test. FoxP3+ lymphocytes were observed in all cases studied. The number of these cells tended to be higher in smaller tumors, tumors without regional lymph node metastasis, and tumors in early clinical stages, but the difference was not statistically significant (p > 0.05). Low-grade tumors contained a larger number of FoxP3+ lymphocytes than high-grade tumors (p = 0.019). Tumors with an intense inflammatory infiltrate exhibited a larger number of Treg cells (p = 0.035). On the other hand, the number of FoxP3+ lymphocytes was smaller in tumors arranged in small cell clusters (p = 0.003). No significant differences in the number of FoxP3+ lymphocytes were observed according to the degree of keratinization (p = 0.525) or nuclear pleomorphism (p = 0.343). The results suggest the participation of Treg cells in immune and inflammatory responses in the microenvironment of LLSCCs. These cells may play a more important role in early stages rather than in advanced stages of lip carcinogenesis.

https://doi.org/10.1590/1807-3107bor-2016.vol30.0130 1086 downloads

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