RESUMO O consumo de dióxido de carbono atmosférico pelo intemperismo tampona o efeito estufa na Terra em escala de tempo geológica. Esse mecanismo é chamado de sumidouro de carbono de silicato (SCS). Saprolito representa parte da frente de intemperismo do manto terrestre, mas historicamente não recebeu muita atenção dos geocientistas. Em escala global, o Brasil é o maior contribuinte para o SCS e o quarto maior contribuinte em número de publicações sobre saprolito. Neste estudo, a produção científica brasileira sobre o assunto de 1990 a 2022 foi avaliada, considerando publicações indexadas nas bases de dados Web of Science, SciELO e Scopus. Foram recuperados cento e oitenta artigos científicos. Na última década, sete artigos foram publicados por ano. Ao longo dos 32 anos considerados, o número de artigos sobre saprolito aumentou. A maioria dos estudos foi concentrada na região sudeste do Brasil, onde o estado de Minas Gerais liderou em termos de número de publicações (28,49%). As principais áreas em que os artigos foram publicados estavam relacionadas à ecologia, Terra e marinha; no entanto, foram citados por várias outras, incluindo as áreas de saúde e política. Uma comparação do número de publicações por bacia e o tamanho do SCS mostrou que havia menos estudos da Bacia Amazônica do que da Bacia do Paraná. Em conclusão, a fronteira geográfica para o estudo do saprolito no território brasileiro é a Bacia do Rio Amazonas, e a fronteira metodológica está relacionada à dinâmica de fluídos/gases e ao papel dos micróbios no intemperismo em profundidade. geológica SCS. . (SCS) terrestre geocientistas global 199 202 avaliada Science Scopus científicos década ano 3 considerados aumentou 28,49%. 2849 28,49% 28 49 (28,49%) ecologia marinha entanto outras política Paraná conclusão Amazonas fluídosgases fluídos gases profundidade (SCS 19 20 284 28,49 2 4 (28,49% 1 28,4 (28,49 28, (28,4 (28, (28 (2 (

ABSTRACT The consumption of atmospheric carbon dioxide by weathering buffers the greenhouse effect on Earth on a geological timescale. This mechanism is called the silicate carbon sink (SCS). Saprolite represents part of the weathering front of the Earth’s mantle, but historically, it has not received much attention from geoscientists. On a global scale, Brazil is the largest contributor to the SCS and the fourth largest contributor to the number of saprolite publications. In this study, Brazilian scientific production on the subject from 1990 to 2022 was assessed, considering publications indexed in the Web of Science, SciELO and Scopus databases. One hundred-eighty scientific articles were retrieved. In the last decade, seven articles were published per year. Over the 32 years under consideration, the number of articles on saprolite has increased. Most of the studies were concentrated in the southeastern region of Brazil, where the state of Minas Gerais led in terms of the number of publications (28.49%). The main areas in which the articles were published were related to ecology, Earth, and marine; however, they were cited by several others, including the areas of health and politics. A comparison of the number of publications per basin and the size of the SCS showed that there were fewer studies from the Amazon Basin than from the Paraná Basin. In conclusion, the geographical frontier for the study of saprolite in the Brazilian territory is the Amazon River Basin, and the methodological frontier is related to fluid/gas dynamics and the role of microbes in weathering at depth. timescale SCS. . (SCS) Earths s mantle historically geoscientists scale 199 202 assessed Science databases hundredeighty hundred eighty retrieved decade year 3 consideration increased 28.49%. 2849 28.49% 28 49 (28.49%) ecology marine however others politics conclusion fluidgas fluid gas depth (SCS 19 20 284 28.49 2 4 (28.49% 1 28.4 (28.49 28. (28.4 (28. (28 (2 (

Abstract Background Tuberous sclerosis complex (TSC) is a multisystem neurocutaneous syndrome with variable phenotypes. Recent updates of TSC diagnostic criteria reaffirmed the defined genetic diagnostic criterion as the finding of a pathogenic DNA alteration in either TSC1 or TSC2 genes. It also slightly modified definite clinical diagnostic criteria. TSC-associated skin lesions in infancy are important clinical signs to select individuals with possible TSC for a closer clinical follow-up and genetic testing. Objective To raise awareness of the updated TSC diagnosis criteria; to assess the frequency of skin lesions in TSC patients as well as the first dermatological presentation; and to associate the findings with either TSC1 or TSC2 mutations. Methods Observational cross-sectional study. Clinical and genetic data were retrospectively collected from 37 TSC patients from a Brazilian University Hospital. Patients with skin signs were examined and prospectively assessed for 12 months. Results The earliest cutaneous lesions were hypomelanotic macules, which together with angiofibromas were the most frequent dermatological lesions. The total pathogenic DNA alteration ratio between TSC2 and TSC1 genes was 8:1. The frequency of a TSC2 pathogenic variant was 10-fold greater in the presence of ungual fibromas. Study limitations Small sample and a limited number of patients with TSC1 pathogenic variants. Conclusion Clinicians should be knowledgeable about TSC updated diagnostic criteria. Patients need to be followed up by a multidisciplinary team and treated accordingly. Early detection of cutaneous lesions is important for TSC diagnosis. A significant association between TSC2 gene pathogenic alterations and ungual fibromas is described. (TSC phenotypes TSCassociated associated followup follow testing presentation mutations crosssectional cross sectional study 3 Hospital 1 months macules 81. 81 8 1. 8:1 10fold fold 10 variants accordingly described 8:

Abstract The scope of this article is to verify if there are differences in factors associated with calcium intake between men and women. It is based on a study conducted with data from a health survey in a sample of 1641 individuals aged 20 years or more living in the urban area of the city of Campinas, in the State of São Paulo. Calcium intake was obtained from a 24-hour recall (24hr recall method) and analyzed according to sociodemographic variables, health behavior, frequency of meals and body mass index (BMI). The existence of associations was verified by multiple linear regression tests, and it was detected that the profile of associated factors differed between genders. Physical exercise in the leisure context was only associated with calcium intake in males, while skin color, smoking, income, overweight/obesity, and frequency of having breakfast only revealed an association in females. Schooling and having snacks were associated with calcium intake in both sexes. The analysis of the associated factors indicates segments of the female and male population in which the importance of calcium intake needs to be more closely examined. Furthermore, it highlights the importance of conducting health analyses stratified by sex due to the different behavioral patterns that prevail between the sexes. women 164 2 Campinas Paulo 24hour hour 24 24hr hr method variables behavior BMI. BMI . (BMI) tests genders males color smoking income overweightobesity overweight obesity overweight/obesity females sexes examined Furthermore 16 (BMI 1

Resumo O objetivo do artigo é verificar se existem diferenças entre os sexos quanto aos fatores que se associam à ingestão de cálcio. Estudo realizado com dados de inquérito de saúde, em amostra de 1.640 indivíduos de 20 anos ou mais residentes no município de Campinas-SP. A ingestão de cálcio foi obtida por meio de um recordatório de 24 horas (R24h) e analisada segundo variáveis sociodemográficas, de comportamentos de saúde, frequência de refeições e índice de massa corporal (IMC); a presença de associações foi verificada por meio de testes de regressão linear múltipla. O perfil de fatores associados à ingestão de cálcio diferiu entre os sexos. A prática de atividade física no contexto de lazer só se associou ao consumo de cálcio no sexo masculino, enquanto cor da pele, tabagismo, renda, excesso de peso e frequência do café da manhã mostraram associação apenas no sexo feminino. Escolaridade e realização de lanches intermediários mostraram-se associadas à ingestão de cálcio em ambos os sexos. A análise aponta segmentos da população feminina e masculina em que a importância da ingestão de cálcio precisa ser mais enfatizada; além disso, alerta para a importância do desenvolvimento de análises de saúde estratificadas por sexo em decorrência de diferentes padrões comportamentais que prevalecem entre os sexos. 1640 1 640 1.64 2 CampinasSP. CampinasSP Campinas SP. SP Campinas-SP R24h Rh R h (R24h sociodemográficas IMC (IMC) múltipla masculino pele tabagismo renda feminino mostraramse enfatizada disso 164 64 1.6 (IMC 16 6 1.

Resumen Objetivo Validar el contenido y la apariencia de un protocolo gráfico para la evaluación del cuidado seguro de enfermería a pacientes en hemodiálisis. Métodos Estudio metodológico con enfoque cuantitativo, organizado en tres procedimientos: teórico, a partir de una scoping review; empírico, donde se realizó el proceso de elaboración del protocolo gráfico y checklist para la evaluación del cuidado seguro; y por último, analítico, para la validación propiamente dicha mediante el uso del método Delphi y la participación de nueve jueces especialistas en dos rondas para alcanzar la concordancia. Resultados Se elaboró la checklist y el protocolo gráfico. Respecto a la validez del contenido, en Delphi I tres criterios obtuvieron Coeficiente de Validez de Contenido = 0,77 en la checklist. En lo referente al Delphi II, se alcanzó el 80 % en todos los ítems relacionados con el Coeficiente de Validez de Contenido, y todos los índices fueron superiores a 0,80. La validación de la apariencia se realizó con los criterios de la Suitability Assessment of Materials en Delphi I. Se logró alcanzar un Coeficiente de Validez de Contenido total mayor a 0,80 en todos, mientras que en Delphi II, los protocolos lograron una concordancia mayor a 80 % y Coeficiente de Validez de Contenido mayor a 0,88, ya que la checklist presentó mayor Coeficiente de Validez de Contenido con 0,91. Conclusión El protocolo gráfico y la checklist para la evaluación del cuidado seguro a pacientes en hemodiálisis demostraron ser válidos en su contenido y apariencia. cuantitativo procedimientos teórico review empírico último analítico 077 0 77 0,7 II 8 080 0,8 088 88 0,88 091 91 0,91 07 7 0, 08 09 9 0,9

Abstract Objective To validate the content and appearance of a graphic protocol for evaluating safe nursing care for hemodialysis patients. Methods Methodological study with a quantitative approach, organized into three procedures: theoretical from a Scoping Review; empirical in which the process of constructing the graphic protocol and checklist for the evaluation of safe care took place; finally, the analytics for the validation itself using the Delphi technique and the participation of nine expert judges in two rounds to reach agreement. Results The checklist and the graphic protocol were elaborated. As for content validity in Delphi I, three criteria obtained Content Validity Coefficient =0.77 in the checklist. In what corresponds to Delphi II, 80% was achieved in all items regarding the Content Validity Coefficient, all indices were above 0.80. Appearance validation took place using criteria of the Suitability Assessment of Materials in Delphi I, it was possible to achieve a total Content Validity Coefficient greater than 0.80 in all, while in Delphi II the protocols reached agreement greater than 80% and Content Validity Coefficient greater than 0.88, since the checklist showed a higher Content Validity Coefficient with 0.91. Conclusion The graphic protocol and checklist for evaluating safe care for hemodialysis patients are presented, valid in their content and appearance. approach procedures Review finally elaborated I 077 0 77 =0.7 80 080 0.8 088 88 0.88 091 91 0.91 presented 07 7 =0. 8 08 0. 09 9 0.9 =0 =

Resumo Objetivo Validar o conteúdo e a aparência de um protocolo gráfico para avaliação do cuidado seguro de enfermagem a pacientes em hemodiálise. Método Estudo metodológico com abordagem quantitativa, organizado em três procedimentos: teóricos, a partir de uma scoping review; empíricos, na qual ocorreu processo de construção do protocolo gráfico e checklist para avaliação do cuidado seguro; por fim, os analíticos, para a validação propriamente dita com uso da técnica Delphi e participação de nove juízes especialistas em duas rodadas para o alcance da concordância. Resultados Elaboraram-se o checklist e o protocolo gráfico. Quanto à validade de conteúdo, em Delphi I, três critérios obtiveram Coeficiente de Validade de Conteúdo =0,77 no checklist. No que corresponde ao Delphi II, foram alcançados 80% em todos os itens referentes ao Coeficiente de Validade de Conteúdo, e todos os índices ficaram acima de 0,80. A validação de aparência ocorreu utilizando critérios de Suitability Assessment of Materials no Delphi I. Foi possível atingir um Coeficiente de Validade de Conteúdo total maior que 0,80 em todos, enquanto que, no Delphi II, os protocolos alcançaram concordância maior que 80% e Coeficiente de Validade de Conteúdo maior que 0,88, já que o checklist apresentou maior Coeficiente de Validade de Conteúdo com 0,91. Conclusão Apresentam-se o protocolo gráfico e o checklist para avaliação do cuidado seguro aos pacientes em hemodiálise válidos em seu conteúdo e aparência. quantitativa procedimentos teóricos review empíricos fim analíticos Elaboraramse Elaboraram se I 077 0 77 =0,7 II 80 080 0,8 088 88 0,88 091 91 0,91 Apresentamse Apresentam 07 7 =0, 8 08 0, 09 9 0,9 =0 =

For decades, lead-acid batteries have been supplying power to electrical systems through redox reactions involving Pb and PbO2. However, the energy supply capacity is inherently constrained by low energy density and challenges associated with charge/discharge cycles. Studies have indicated that additions of C to the composition of the active mass improve the electrochemical properties of batteries. This work aims to produce, characterize the microstructure and evaluate the electrochemical properties of Pb-Carbon composites, comparing different types of C (graphite, graphene and xerogel). The samples were produced through powder metallurgy, pressed at 550 MPa and sintered at 320°C-48 h. The microstructure was characterized by XRD, SEM/EDS, and Vickers microhardness. Electrochemical analyses were evaluated through OCP, polarization, and cyclic voltammetry (CV) measurements in a solution of 4.91 mol•L-1 of H2SO4. Microstructural characterizations revealed dispersions of C particles in the Pb matrix and an increase in the microhardness of the composites. Electrochemical analyses showed an increase in polarization resistance and a reduction in the corrosion rate compared to Pb. CV curves, demonstrated that C particles enhanced electrical conductivity for the formation of PbSO4 and PbO2, allowing greater absorption of electrical overpotentials when compared to Pb, thereby improving charge/discharge cycles in positive grids. decades leadacid lead acid PbO2 PbO However chargedischarge charge discharge produce PbCarbon Carbon composites graphite, graphite (graphite xerogel. xerogel . xerogel) metallurgy 55 320°C48 320C48 320°C 48 320 320°C-4 h XRD SEMEDS SEM EDS SEM/EDS OCP (CV 491 4 91 4.9 mol•L1 molL1 molL mol•L 1 mol L mol•L- H2SO4 HSO H SO curves PbSO grids 5 C48 320°C4 320C4 320C 32 320°C- 49 9 4. L1 H2SO C4 3

Abstract This study aims to understand the meanings related to sexual health and the delineations that define the experience of accessing health services for lesbian women in Manaus, Brazil. This study followed a qualitative approach, counting on the participation of ten women who self-reported themselves as lesbians. Semi-structured interviews were carried out and their analyses occurred through three thematic axes. The first addressed the representations concerning prevention and sexual practices, highlighting the notion of fidelity in the relationship as a “protective factor”. Difficulties in the use of condoms in relationships between two women were reported. The second discussed heteronormativity and its effects on self-care, reporting the participants’ difficulties in being understood and welcomed by health services. The third addressed the search for one’s own knowledge as a care tactic, highlighting the importance of information and autonomy for health promotion and prevention of Sexually Transmitted Infections (STIs). It can therefore be concluded that there is a need for public policies aimed at promoting the sexual health of lesbian women and the recognition of their specificities by health services. Manaus Brazil approach selfreported self reported lesbians Semistructured Semi structured axes practices protective factor. factor . factor” selfcare, selfcare care, self-care participants ones one s tactic STIs. STIs (STIs) (STIs

Resumo O estudo tem por objetivo compreender os significados relacionados à saúde sexual e os contornos que definem a experiência de acesso aos serviços de saúde para mulheres lésbicas de Manaus, Amazonas. Trata-se de uma pesquisa de abordagem qualitativa. Contou com a participação de dez mulheres que se autoidentificaram como lésbicas. Foram realizadas entrevistas semiestruturadas e suas análises ocorreram por meio de três eixos temáticos. O primeiro abordou as representações sobre prevenção e práticas sexuais, destacando a noção de fidelidade no relacionamento como “fator de proteção”. Foram relatadas dificuldades no uso de preservativos em relações entre duas mulheres. O segundo discutiu a heteronormatividade e seus efeitos no cuidado de si, relatando as dificuldades de as participantes serem compreendidas e acolhidas pelos serviços de saúde. O terceiro abordou a busca do próprio conhecimento como tática de cuidado, destacando a importância da informação e da autonomia para a promoção da saúde e a prevenção de infecções sexualmente transmissíveis. Conclui-se que existe a necessidade de políticas públicas voltadas para a promoção da saúde sexual de mulheres lésbicas e o reconhecimento de suas especificidades pelos serviços de saúde. Manaus Amazonas Tratase Trata qualitativa temáticos sexuais fator proteção. proteção . proteção” si transmissíveis Concluise Conclui

ABSTRACT. Fig orchard expansion requires knowledge of the thermal requirements of genotypes available in different climatic regions. The budburst of fig cultivars was assessed by biological single-node cutting and exposure to artificial chilling. Cuttings from five cultivars were collected during two crop seasons, subsequently packaged in a horizontal position in a cold chamber (8 ± 0.5ºC), and artificially chilled for 0, 40, 80, 120, and 160h. Cuttings were preserved under controlled conditions (23 ± 1°C, RH 85%, and 16h photoperiod). The variables evaluated were the budding velocity, average time and final rate of sprouting, vigorous shoot rate, and average time to leaf opening. The single-node cutting test allowed the assessment of dormancy, which is influenced by the accumulation of chilling in each crop season. The average time and final budding rate varied depending on the temperature requirements for budding. The cultivars were classified on an increasing scale according to their chilling requirements as follows: Pingo de Mel < Roxo de Valinhos < Brown Turkey < White Genova < Troyano. The traditional cultivar in Brazil is Roxo de Valinhos, but all of the cultivars studied had the potential to diversify the fig orchards in this region. ABSTRACT regions singlenode single node seasons 8 ( 0.5ºC, 05ºC ºC 0.5ºC , 0 5ºC 0.5ºC) 40 80 120 160h h 23 (2 1C C 1 1°C 85 85% photoperiod. photoperiod . photoperiod) velocity sprouting opening dormancy season follows Troyano region 4 12 2

ABSTRACT OBJECTIVE This study aims to integrate the concepts of planetary health and big data into the Donabedian model to evaluate the Brazilian dengue control program in the state of São Paulo. METHODS Data science methods were used to integrate and analyze dengue-related data, adding context to the structure and outcome components of the Donabedian model. This data, considering the period from 2010 to 2019, was collected from sources such as Department of Informatics of the Unified Health System (DATASUS), the Brazilian Institute of Geography and Statistics (IBGE), WorldClim, and MapBiomas. These data were integrated into a Data Warehouse. K-means algorithm was used to identify groups with similar contexts. Then, statistical analyses and spatial visualizations of the groups were performed, considering socioeconomic and demographic variables, soil, health structure, and dengue cases. OUTCOMES Using climate variables, the K-means algorithm identified four groups of municipalities with similar characteristics. The comparison of their indicators revealed certain patterns in the municipalities with the worst performance in terms of dengue case outcomes. Although presenting better economic conditions, these municipalities held a lower average number of community healthcare agents and basic health units per inhabitant. Thus, economic conditions did not reflect better health structure among the three studied indicators. Another characteristic of these municipalities is urbanization. The worst performing municipalities presented a higher rate of urban population and human activity related to urbanization. CONCLUSIONS This methodology identified important deficiencies in the implementation of the dengue control program in the state of São Paulo. The integration of several databases and the use of Data Science methods allowed the evaluation of the program on a large scale, considering the context in which activities are conducted. These data can be used by the public administration to plan actions and invest according to the deficiencies of each location. Paulo denguerelated 201 2019 DATASUS, DATASUS , (DATASUS) IBGE, IBGE (IBGE) WorldClim MapBiomas Warehouse Kmeans K means contexts Then performed variables soil cases characteristics outcomes inhabitant Thus urbanization scale conducted location 20 (DATASUS (IBGE 2

RESUMO OBJETIVO Integrar os conceitos de Saúde Planetária e Big Data ao modelo de Donabedian, para avaliar o Programa de Combate à Dengue no estado de São Paulo. MÉTODOS Foram adotados métodos de Ciência de Dados para integração e análise de dados relacionados à dengue, agregando o contexto aos componentes de estrutura e de resultado do modelo de Donabedian. Esses dados, considerando o período de 2010 a 2019, foram coletados de fontes como Datasus, Instituto Brasileiro de Geografia e Estatística (IBGE), WorldClim e MapBiomas, e integrados em um Data Warehouse. Para a identificação de grupos com contextos similares, foi utilizado o algoritmo K-means. Em seguida, foram realizadas análises estatísticas e visualizações espaciais dos grupos, considerando variáveis socioeconômicas, demográficas, solo, estrutura de saúde e casos de dengue. RESULTADOS Com o uso das variáveis climáticas, o algoritmo K-means identificou quatro grupos de municípios com características similares. A comparação dos seus indicadores revelou certos padrões nos municípios com pior desempenho quanto aos resultados de casos de dengue. Embora tivessem melhores condições econômicas, eles tinham menor número médio de agentes comunitários e de unidades básicas de saúde por habitante. Dessa forma, as condições econômicas não refletiram em melhor estrutura de saúde nos três indicadores avaliados. Outra característica desses municípios é a urbanização. Os municípios de pior desempenho tinham maior taxa de população urbana e de modificações antrópicas relacionadas à urbanização. CONCLUSÕES Por meio desta metodologia, foi possível identificar importantes deficiências nas condições para a execução do programa de combate à dengue no estado de São Paulo. A integração de diversas bases de dados e a utilização de métodos de Ciência de Dados permitiram a avaliação do programa em larga escala, considerando o contexto em que as ações são executadas. Dessa forma, a gestão pública pode utilizar as informações coletadas para planejar ações e investir de acordo com as deficiências de cada local. Donabedian Paulo 201 2019 Datasus IBGE, IBGE , (IBGE) MapBiomas Warehouse similares Kmeans. Kmeans K means. means seguida socioeconômicas demográficas solo climáticas habitante forma avaliados urbanização metodologia escala executadas local 20 (IBGE 2

Abstract Objective To adapt the Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient (CuPDPH) to the Brazilian language and culture and to assess its psychometric properties. Results The scale was evaluated by 15 experts, and 239 patients from three tertiary hospitals in Rio de Janeiro. All participants signed a consent form. Data have shown adequacy of the model (KMO=0.839, Bartlett's test of sphericity: χ2(171) = 2241.3, p = 0.000010), good adjusted content validity (CVCa ≥ 0.90), internal consistency and reliability, such as α = 0.927. Discussion CuPDPH is a rating scale on observable professional attitudes. Illnesses change lives and impose adaptation to a new situation, perceived as depersonalization, leading patients to try to regain control of their lives. Patients expressed “ill will” to fill out the scale. Psychiatric patients’ scale filling time was higher than others. A sample from three Rio de Janeiro third-level hospitals may not reflect the country's population; also, this adaptation may not comprise all linguistic variations of Brazilian Portuguese and Portuguese-speaking countries. Conclusion The Portuguese version of the Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient (CuPDPH), a 19-item, six-component version is a reliable instrument to measure the perception of internal medicine, surgical, and psychiatric patients on the maintenance of their dignity in Rio de Janeiro, Brazil. This knowledge could be used in advancing research on patients’ perception of dignity, as well as professional ethical competencies, staff-patient relationship skills, and leadership development in medical and other healthcare professional education. (CuPDPH properties 1 experts 23 form KMO=0.839, KMO0839 KMO 0 839 (KMO=0.839 Bartletts Bartlett s sphericity χ2171 χ χ2 171 χ2(171 22413 2241 3 2241.3 0.000010, 0000010 0.000010 , 000010 0.000010) CVCa 0.90, 090 0.90 90 0.90) reliability 0927 927 0.927 attitudes situation depersonalization ill will others thirdlevel third level countrys country population also Portuguesespeaking speaking countries CuPDPH, 19item, 19item item 19 item, 19-item sixcomponent six component medicine surgical Brazil competencies staffpatient staff patient skills education 2 KMO=0.839 KMO083 83 (KMO=0.83 χ217 17 χ2(17 224 2241. 000001 0.00001 00001 09 0.9 9 092 92 0.92 KMO=0.83 KMO08 8 (KMO=0.8 χ21 χ2(1 22 00000 0.0000 0000 0. KMO=0.8 KMO0 (KMO=0. χ2( 0.000 000 KMO=0. (KMO=0 0.00 00 KMO=0 (KMO= 0.0 KMO= (KMO

Abstract Introduction: Metabolic syndrome (MS) and obesity are risk factors for cardiovascular diseases (CVD). However, the development of cardiovascular pathologies in obese individuals without MS is being investigated. Objective: To investigate whether there are similar electrocardiographic (ECG) and echocardiographic changes in individuals with obesity with and without MS. Methodology: A retrospective, descriptive cross-sectional study was carried out with obese patients at a university hospital in Belém, Pará, Brazil. Anthropometric, laboratory, ECG and echocardiographic data were evaluated in both populations. The chi-square test was used to describe the relationship between variables among groups; hypothesis tests with p < 0.05 were considered statistically significant values. Results: The study evaluated 100 individuals with obesity, 60 of whom had MS. The average age was 54 years, and the female sex was prevalent. Systolic blood pressure, HDL, and waist circumference were altered in both groups. Systemic arterial hypertension and low HDL demonstrated 4.27 times and 3.32 times greater likelihood of presenting changes in the ECG and echocardiogram for both groups. On the ECG, diffuse changes in ventricular repolarization were observed in both groups. On echocardiography, left ventricular diastolic dysfunction and left ventricular hypertrophy were present in both populations studied. Conclusion: Obese individuals without MS present a similar risk, requiring adequate attention to their cardiac health. Introduction (MS CVD. CVD . (CVD) However investigated Objective (ECG Methodology retrospective crosssectional cross sectional Belém Pará Brazil Anthropometric laboratory chisquare chi square groups 005 0 05 0.0 values Results 10 6 5 years prevalent pressure 427 4 27 4.2 332 3 32 3.3 echocardiography studied Conclusion health (CVD 00 0. 1 42 2 4. 33 3.

ABSTRACT Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022. The primary outcome was all-cause mortality. Of 49 cases, 63.2% were male with a median age of 47 years. Allogeneic-HSCT (51.2%) and autologous-HSCT (48.9%) patients were included. The median time from HSCT to COVID-19 diagnosis was 398 days (IQR: 1211-134), with 22 (44.8%) cases occurring within 12 months of transplantation. Most cases occurred during the first year of the pandemic, in non-vaccinated patients (n=35; 71.4%). Most patients developed severe (24.4%) or critical (40.8%) disease; 67.3% received some medication for COVID-19, primarily corticosteroids (53.0%). The probable invasive aspergillosis prevalence was 10.2%. All-cause mortality was 40.8%, 51.4% in non-vaccinated patients and 14.2% in patients who received at least one dose of the vaccine. In the multiple regression analyses, the variables mechanical ventilation (OR: 101.01; 95% CI: 8.205 – 1,242.93; p = 0.003) and chest CT involvement at diagnosis ≥50% (OR: 26.61; 95% CI: 1.06 – 664.26; p = 0.04) remained associated with all-cause mortality. Thus, HSCT recipients with COVID-19 experienced high mortality, highlighting the need for full vaccination and infection prevention measures. (HSCT increased COVID19. COVID19 COVID 19. 19 COVID-1 Paulo postHSCT, postHSCT post HSCT, post-HSCT 202 2022 allcause all cause 4 632 63 2 63.2 years AllogeneicHSCT Allogeneic 51.2% 512 51 (51.2% autologousHSCT autologous 48.9% 489 48 9 (48.9% included 39 IQR (IQR 1211134, 1211134 1211 134 , 1211-134) 44.8% 448 44 8 (44.8% 1 transplantation pandemic nonvaccinated non vaccinated n=35 n35 n 35 (n=35 71.4%. 714 71.4% . 71 71.4%) 24.4% 244 24 (24.4% 40.8% 408 40 (40.8% disease 673 67 3 67.3 COVID19, 19, 53.0%. 530 53.0% 53 0 (53.0%) 102 10 10.2% Allcause All 514 51.4 142 14 14.2 vaccine analyses OR (OR 101.01 10101 101 01 95 CI 8205 205 8.20 1,242.93 124293 242 93 0.003 0003 003 50 ≥50 26.61 2661 26 61 106 06 1.0 664.26 66426 664 0.04 004 04 Thus measures COVID1 COVID- 20 6 63. 51.2 5 (51.2 48.9 (48.9 121113 121 13 1211-134 44.8 (44.8 n=3 n3 (n=3 71.4 7 24.4 (24.4 40.8 (40.8 67. 53.0 (53.0% 10.2 51. 14. 101.0 1010 820 8.2 1,242.9 12429 0.00 000 00 ≥5 26.6 266 1. 664.2 6642 66 0.0 (51. 48. (48. 12111 1211-13 44. (44. n= (n= 71. 24. (24. 40. (40. 53. (53.0 10. 101. 82 8. 1,242. 1242 ≥ 26. 664. 0. (51 (48 1211-1 (44 (n (24 (40 (53. 1,242 124 (5 (4 1211- (2 (53 1,24 ( 1,2 1,

ABSTRACT Objective To evaluate the association between dietary self-perception and socioeconomic, health, diet, and lifestyle variables of socially vulnerable women in primary health care. Methods This cross-sectional study was conducted in a Primary Health Care Unit in Fortaleza, Ceará, with 158 women beneficiaries of the Bolsa Família (Family Aid) Program. We applied a questionnaire containing socioeconomic and health variables, food knowledge, and self-perception. Pearson's chi-square test, with a 5% significance level, was adopted to investigate possible associations between women's food self-perception and other variables. Results The women had a mean age of 31.2 years. Most had a household income of less than one minimum wage (75.9%), a high school education level (53.8%), were overweight (67.7%), did not engage in physical activity (72.8%), and received dietary guidance (51.9%). Negative dietary self-perception was reported by 57.0% of the sample. Women who did not engage in physical activity had a higher frequency of negative dietary self-perception (p=0.007). Conclusion Most women showed negative dietary self-perception. The variable “physical activity” was positively associated with dietary self-perception. Knowing how women perceive their diet and which factors are associated with their food choices can help health professionals in their daily conduct in health care units. selfperception self perception crosssectional cross sectional Fortaleza Ceará 15 Family Aid Program knowledge selfperception. perception. Pearsons Pearson s chisquare chi square test 5 womens 312 31 2 31. years 75.9%, 759 75.9% , 75 9 (75.9%) 53.8%, 538 53.8% 53 8 (53.8%) 67.7%, 677 67.7% 67 7 (67.7%) 72.8%, 728 72.8% 72 (72.8%) 51.9%. 519 51.9% . 51 (51.9%) 570 57 0 57.0 sample p=0.007. p0007 p p=0.007 007 (p=0.007) units 1 3 75.9 (75.9% 53.8 (53.8% 67.7 6 (67.7% 72.8 (72.8% 51.9 (51.9% 57. p000 p=0.00 00 (p=0.007 75. (75.9 53. (53.8 67. (67.7 72. (72.8 51. (51.9 p00 p=0.0 (p=0.00 (75. (53. (67. (72. (51. p0 p=0. (p=0.0 (75 (53 (67 (72 (51 p=0 (p=0. (7 (5 (6 p= (p=0 ( (p= (p

RESUMO Objetivo Avaliar a associação entre a autopercepção alimentar negativa e variáveis socioeconômicas, de saúde, alimentação e estilo de vida de mulheres em vulnerabilidade social, na atenção primária à saúde. Métodos Estudo do tipo transversal realizado em uma Unidade de Atenção Primária à Saúde de Fortaleza, Ceará, com 158 mulheres beneficiárias do Programa Bolsa Família. Um questionário foi aplicado contendo as variáveis investigadas. O teste Qui-quadrado de Pearson, com nível de significância 5% foi utilizado para investigar possíveis associações entre a autopercepção alimentar das mulheres e as demais variáveis. Resultados As mulheres apresentaram média de idade de 31,2 anos e a maioria tinha renda familiar inferior a um salário-mínimo (75,9%), ensino médio como o nível de escolaridade (53,8%), apresentou excesso de peso (67,7%), não praticava atividade física (72,8%) e recebeu orientações sobre alimentação (51,9%). A autopercepção alimentar negativa foi relatada por 57,0% da amostra. As mulheres que não praticavam atividade física, tiveram maior frequência de autopercepção alimentar negativa (p=0,007). Conclusão A maioria das mulheres apresentou autopercepção negativa da alimentação e a variável “atividade física” mostrou associação positiva em relação à autopercepção alimentar. Conhecer como as mulheres percebem sua alimentação e quais fatores se associam às suas escolhas pode auxiliar os profissionais de saúde em suas condutas no cotidiano dos atendimentos nas unidades de saúde. socioeconômicas social Fortaleza Ceará 15 Família investigadas Quiquadrado Qui quadrado Pearson 5 312 31 2 31, saláriomínimo salário mínimo 75,9%, 759 75,9% , 75 9 (75,9%) 53,8%, 538 53,8% 53 8 (53,8%) 67,7%, 677 67,7% 67 7 (67,7%) 72,8% 728 72 (72,8% 51,9%. 519 51,9% . 51 (51,9%) 570 57 0 57,0 amostra p=0,007. p0007 p p=0,007 007 (p=0,007) 1 3 75,9 (75,9% 53,8 (53,8% 67,7 6 (67,7% 72,8 (72,8 51,9 (51,9% 57, p000 p=0,00 00 (p=0,007 75, (75,9 53, (53,8 67, (67,7 72, (72, 51, (51,9 p00 p=0,0 (p=0,00 (75, (53, (67, (72 (51, p0 p=0, (p=0,0 (75 (53 (67 (7 (51 p=0 (p=0, (5 (6 ( p= (p=0 (p= (p

Abstract The aim of this study was to determine the endothelial cell morphology in the different regions of healthy bovine corneal endothelium using optical microscopy. Twenty eyeballs from 10 male Brangus cattle, aged 24 months, were studied. The corneal endothelium was stained with the vital dye alizarin red and then examined with an optical microscope and photographed. Thirty endothelial cells from each corneal region were included in the analysis. Endothelial cell morphology was analysed in the central, superior, inferior, lateral and medial regions of the cornea. Comparisons between regions were performed using repeated measures analysis of variance (ANOVA). Differences were considered statistically significant at P < 0.05. Normal endothelial cells were mainly hexagonal (83.7%), pentagonal (7.45%) and heptagonal (8.8%), with a minimal number of cells of other shapes present. No statistical differences were observed in the endothelial cell morphology when comparing different regions of the cornea. Regarding endothelial cell morphology, there were no differences between the corneal regions. microscopy 1 cattle 2 months studied photographed central superior inferior cornea ANOVA. ANOVA . (ANOVA) 005 0 05 0.05 83.7%, 837 83.7% , 83 7 (83.7%) 7.45% 745 45 (7.45% 8.8%, 88 8.8% 8 (8.8%) present (ANOVA 00 0.0 83.7 (83.7% 7.45 74 4 (7.45 8.8 (8.8% 0. 83. (83.7 7.4 (7.4 8. (8.8 (83. 7. (7. (8. (83 (7 (8 (

Resumo O objetivo deste estudo foi determinar a morfologia das células endoteliais nas diferentes regiões do endotélio da córnea bovina saudável por meio de microscopia óptica. Foram estudados 20 globos oculares de 10 bovinos machos da raça Brangus, com idade de 24 meses. O endotélio da córnea foi corado com o corante vital vermelho de alizarina e, em seguida, examinado no microscópio óptico e fotografado. Trinta células endoteliais de cada região da córnea foram incluídas na análise. A morfologia das células endoteliais foi analisada nas regiões central, superior, inferior, lateral e medial da córnea. As comparações entre as regiões foram realizadas usando medidas repetidas de análise de variância (ANOVA). As diferenças foram consideradas estatisticamente significativas em P < 0,05. As células endoteliais normais eram principalmente hexagonais (83,7%), pentagonais (7,45%) e heptagonais (8,8%), com um número mínimo de células de outras formas presentes. Não foram observadas diferenças estatísticas na morfologia das células endoteliais quando comparadas as diferentes regiões da córnea. Em relação à morfologia das células endoteliais não houve diferenças entre as regiões da córnea estudadas. óptica 2 1 Brangus meses seguida fotografado central superior inferior ANOVA. ANOVA . (ANOVA) 005 0 05 0,05 83,7%, 837 83,7% , 83 7 (83,7%) 7,45% 745 45 (7,45% 8,8%, 88 8,8% 8 (8,8%) presentes estudadas (ANOVA 00 0,0 83,7 (83,7% 7,45 74 4 (7,45 8,8 (8,8% 0, 83, (83,7 7,4 (7,4 8, (8,8 (83, 7, (7, (8, (83 (7 (8 (

Abstract There is growing interest in using cannabinoids across various clinical scenarios, including pain medicine, leading to the disregard of regulatory protocols in some countries. Legislation has been implemented in Brazil, specifically in the state of São Paulo, permitting the distribution of cannabinoid products by health authorities for clinical purposes, free of charge for patients, upon professional prescription. Thus, it is imperative to assess the existing evidence regarding the efficacy and safety of these products in pain management. In light of this, the São Paulo State Society of Anesthesiology (SAESP) established a task force to conduct a narrative review on the topic using the Delphi method, requiring a minimum agreement of 60% among panelists. The study concluded that cannabinoid products could potentially serve as adjuncts in pain management but stressed the importance of judicious prescription. Nevertheless, this review advises against their use for acute pain and cancer-related pain. In other clinical scenarios, established treatments should take precedence, particularly when clinical protocols are available, such as in neuropathic pain. Only patients exhibiting poor therapeutic responses to established protocols or demonstrating intolerance to recommended management may be considered as potential candidates for cannabinoids, which should be prescribed by physicians experienced in handling these substances. Special attention should be given to individual patient characteristics and the likelihood of drug interactions. scenarios medicine countries Brazil purposes prescription Thus SAESP (SAESP method 60 panelists Nevertheless cancerrelated cancer related precedence available substances interactions 6