Pesquisa | SciELO

Abstract Background: Real-world, primary data on the treatment of psoriasis are scarce, especially concerning the role of soluble biomarkers as outcome predictors. Objective: The authors evaluated the utility of Th1/Th17 serum cytokines along with clinical characteristics as predictors of drug survival in the treatment of psoriasis. Methods: The authors consecutively included participants with moderate to severe psoriasis who were followed up for 6 years. Baseline interferon-α, tumor necrosis factor-α, and inter-leukin (IL)-2, IL-4, IL-6, IL-10, and IL-17A were measured using a cytometric bead array; clinical data were assessed. The authors calculated hazard ratios (HRs) for drug survival using a Cox proportional hazards model. Results: The authors included 262 patients, most of whom used systemic immunosuppressants or biologics. In the multivariate model, poor quality of life measured by the Dermatology Life Quality Index (HR = 1.04; 95% CI 1.01–1.07; p = 0.012) and elevated baseline IL-6 (HR = 1.99; 95% CI 1.29–3.08; p = 0.002) were associated with treatment interruption. Study limitations: The main limitation of any cohort study is the presence of confounders that could not be detected in clinical evaluation. Conclusions: Poor quality of life and elevated baseline serum IL-6 level predicted treatment interruption in patients with moderate to severe psoriasis. Although IL-6 is not the most important mediator of the inflammatory pathway in the skin environment, it is an interesting biomarker candidate for predicting psoriasis treatment response. Background Realworld, Realworld Real world, world Real-world scarce Objective Th1Th17 ThTh Th1 Th17 Th Th1/Th1 Methods years interferonα, interferonα interferon α, α interferon-α factorα, factorα factor factor-α interleukin inter leukin IL2, IL2 IL 2, 2 (IL)-2 IL4, IL4 4, 4 IL-4 IL6, IL6 6, IL10, IL10 10, 10 IL-10 IL17A ILA 17A A array assessed HRs (HRs model Results 26 biologics HR 1.04 104 1 04 95 1.01–1.07 101107 01 07 0.012 0012 0 012 IL- 1.99 199 99 1.29–3.08 129308 29 3 08 0.002 0002 002 limitations evaluation Conclusions environment response Th1Th1 Th1/Th (IL)- IL1 IL-1 1.0 9 1.01–1.0 10110 0.01 001 1.9 19 1.29–3.0 12930 0.00 000 00 Th1Th (IL) 1. 1.01–1. 1011 0.0 1.29–3. 1293 (IL 1.01–1 101 0. 1.29–3 129 1.01– 1.29– 12 1.01 1.29 1.2

https://doi.org/10.1016/j.abd.2023.03.002

Relato de caso: persistência da artéria isquiática completa bilateral associada à degeneração aneurismática caso
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Togni Filho, Paulo Henrique Alves

; Leite, André Luís Santos Vaz

; Sampaio, Marcela Prando

; Castro, Beatriz Camargo

; Rodrigues, Henrique Tomaz

; Paro, Guilherme Augusto

Jornal Vascular Brasileiro

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2024, Volume 23 elocation e20230151

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A persistência da artéria isquiática é uma anomalia congênita rara, com poucos casos descritos na literatura. Este estudo tem como objetivo apresentar a variação embriológica observada no sistema circulatório de membros inferiores da paciente observada. A descrição anatômica foi realizada a partir da revisão de prontuário e exames de imagem. O presente caso relata uma paciente feminina, de 63 anos de idade, admitida em serviço de pronto atendimento com queixa de dor importante em membro inferior direito, com extremidade fria e pálida e presença de equimose em dorso do pé. Realizou-se duplex scan que evidenciou ausência de fluxo detectável nas artérias tibial anterior e fibular, e padrão tardus parvus na artéria tibial posterior. A paciente evoluiu com perda de movimentação e cianose fixa no pé direito e foi encaminhada para tromboembolectomia de urgência, entretanto, após o procedimento, não foi visualizado reperfusão adequada. No primeiro pós-operatório, foi realizada angiotomografia, que evidenciou persistência da artéria isquiática bilateralmente, com degeneração aneurismática parcialmente trombosada e ausência de opacificação do sistema arterial à jusante do aneurisma. No terceiro dia pós-operatório, a paciente apresentava áreas de necrose seca em membro, sem perfusão até tornozelo, e foi submetida à amputação transfemoral. Apesar de ser uma condição rara, apresenta grande importância clínica devido a suas altas taxas de complicações. rara literatura imagem feminina 6 idade Realizouse Realizou se fibular posterior urgência entretanto procedimento adequada pósoperatório, pósoperatório pós operatório, operatório pós-operatório angiotomografia bilateralmente aneurisma tornozelo transfemoral complicações

Abstract Persistent sciatic artery is a rare congenital anomaly, with few cases described in the literature. This study presents a case of this embryological variation observed in a patient’s lower limb circulatory system. The anatomical description is based on a review of medical records and imaging exams. This case report describes a 63-year-old female patient admitted to the emergency department complaining of severe pain in the right lower limb, with a cold, pale extremity and ecchymosis on the dorsum of the foot. Duplex ultrasound showed no detectable flow in the anterior tibial and fibular arteries and a tardus parvus pattern in the posterior tibial artery. The patient developed loss of movement and fixed cyanosis in the right foot and was referred for urgent thromboembolectomy. However, adequate reperfusion was not seen after the procedure. Angiotomography was performed on the first postoperative day, showing bilateral persistence of the sciatic artery, with aneurysmal degeneration, partially thrombosed, and no opacification of the arterial system downstream of the aneurysm. By the third postoperative day, the patient had developed areas of dry necrosis in the limb, with no perfusion to the ankle, and underwent transfemoral amputation. Despite being a rare condition, it is of great clinical importance because of the high complication rates. anomaly literature patients s exams 63yearold yearold 63 year old cold thromboembolectomy However procedure day degeneration thrombosed aneurysm ankle amputation condition rates 6

https://doi.org/10.1590/1677-5449.202301511

Cell sheet produced from periodontal ligament stem cells activated by PAR1 improves osteogenic differentiation PAR
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GASPARONI, Letícia Miquelitto

; ALVES, Tomaz

; FRANÇA, Bruno Nunes de

; BALZARINI, Danilo

; ALBUQUERQUE-SOUZA, Emmanuel

; PEDRONI, Ana Clara Fagundes

; ROVAI, Emanuel da Silva

; MENDOZA, Aldrin Huamán

; SIPERT, Carla Renata

; HOLZHAUSEN, Marinella

Brazilian Oral Research

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2024, Volume 38 elocation e079

Resumo: En | Texto: En | PDF: En

Abstract Periodontal regeneration is a challenge, and tissue engineering based on periodontal ligament stem cells (PDLSCs) has been shown to be a promising alternative to this process. However, the need for scaffolds has limited the therapeutic use of PDLSCs. In this context, scaffold-free tissue engineering using the cell sheet (CS) technique has been developed as an alternative approach to improve tissue regeneration. Previously, we showed that Protease-activated receptor-1 (PAR1) can regulate PDLSCs. Herein, we evaluate whether PAR1 influences osteogenesis in CSs produced from PDLSCs, without the use of scaffolds. PDLSCs were isolated and immunophenotyped. Then, CSs were obtained by supplementing the culture medium with ascorbic acid (50 µg/mL), and PAR1 was activated through its agonist peptide (100 nM). Scaffold-free 3D CSs were successfully produced from PDLSCs, and they showed higher proliferation potential than isolated PDLSCs. Also, PAR1 activation decreased senescence and improved osteogenic differentiation of CSs by increasing mineralized nodule deposition and alkaline phosphatase concentration; PAR1 also modulated osteogenic markers at the gene and protein levels. We further demonstrated that this effect was regulated by Wnt, TGF-βI, MEK, p38 MAPK, and FGF/VEGF signaling pathways in PDLSCs (p < 0.05%). Overall, PAR1 activation increased osteogenic activity in CSs, emerging as a promising scaffold-free therapeutic approach for periodontal regeneration. challenge (PDLSCs process However context scaffoldfree scaffold free CS (CS Previously Proteaseactivated Protease receptor1 receptor 1 receptor- PAR (PAR1 Herein immunophenotyped Then 50 (5 µg/mL, µgmL µg/mL , µg mL µg/mL) 100 (10 nM. nM . nM) Scaffoldfree Scaffold D Also concentration levels Wnt TGFβI, TGFβI TGF βI, βI TGF-βI MEK p p3 MAPK FGFVEGF FGF VEGF 0.05%. 005 0.05% 0 05 0.05%) Overall (PAR 5 ( 10 (1 00 0.05 0.0 0.

https://doi.org/10.1590/1807-3107bor-2024.vol38.0079

[SciELO Preprints] - MAKING "MACUMBA", MAKING AN EPISTEMOLOGICAL "EBÓ": THE BODIES IN AFRICAN ORIGIN RELIGIONS
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Santos, Yuri Tomaz dos Carmo, Fabiana Marques do Oliveira , Esmael Alves de

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Data de publicação: 2023-09-18

Resumo: En Pt

This article's objective is to ruminate about the social markers of difference, giving the tonics to the comprehension of the bodies and its corporeities as enunciators and focal points of this evocation, coming from the idea of cross streets and investing in a deal a bit of a stretch of the religion marker, that is adjacent to others, as operators of a epistemological "ebó" that evoques both the agencyand the "macumba" as political acts from the notion of the "macumba". We spat "pemba" powder on the nudity of the bodies, flaking enunciations and complaints that afrograph those corporeities that have the ancestry as their focal point. We identified in our observations and constant dialogues that, in the five african origin cults studied, how the markers are seasonal and say so much about processes/moviments of recognition and visibility, while the oral literatures of these bodies find focal points of escape in the transgression of the hegemony by rescuing a political and practical way of reframing the colonial crosses that objectfy and desubjectivate these body-subjects, whose semiology finds its place in the religious emotions, that reverberate in affections, discourses and ways of existing in the world from the cosmooperation, in a local ontology that puts into play the markers when living physiologyical-political-religous from a macumba-acting body and the amefricantlanticized ontology.

O trabalho em tela como objetivo ruminar sobre os marcadores sociais da diferença, dando a tônica para a compreensão dos corpos e das corporeidades como enunciadores e pontos centrais dessa evocação, a partir da ideia de encruzilhada e investindo em uma aposta tanto de um esgarçamento do marcador religião, adjacente a outros, como operador(es) de um ebó epistemológico que tanto evoca a agência e a macumba como um ato de fazer política a partir da noção da macumba. Escarramos pó de pemba sobre o nu dos corpos, descamando (d)enunciações que tanto afrografam essas corporeidades que têm como centralidade a ancestralidade. Constatamos em nossas observações e constantes diálogos retornados, nos cinco cultos de matriz africana elencados, como os marcadores são sazonais e tanto dizem de processos/movimentos de reconhecimento e visibilidade, ao passo que as oralituras desses corpos encontram pontos focais de fuga à colonialidade a partir da transgressão à hegemonia ao resgatar um modo político e actante de ressignificar os cruzos do colonialismo que objetificam e desubjetivam esses corpos-sujeitos, cuja semiologia encontra lugar nas emoções religiosas, as quais reverberam em afetos, discursos e modos de colocação no mundo a partir da cosmopercepção, dentro de uma ontologia local que coloca em jogo os marcadores ao viver uma filosogia-política-religiosa a partir do corpo como macumba-actante e da ontologia amefricantlatizada.

https://doi.org/10.1590/SciELOPreprints.6793

Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023 202 20 2
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Marin-Neto, José Antonio

; Rassi Jr, Anis

; Oliveira, Gláucia Maria Moraes

; Correia, Luís Claudio Lemos

; Ramos Júnior, Alberto Novaes

; Luquetti, Alejandro Ostermayer

; Hasslocher-Moreno, Alejandro Marcel

; Sousa, Andréa Silvestre de

; Paola, Angelo Amato Vincenzo de

; Sousa, Antônio Carlos Sobral

; Ribeiro, Antonio Luiz Pinho

; Correia Filho, Dalmo

; Souza, Dilma do Socorro Moraes de

; Cunha-Neto, Edecio

; Ramires, Felix Jose Alvarez

; Bacal, Fernando

; Nunes, Maria do Carmo Pereira

; Martinelli Filho, Martino

; Scanavacca, Maurício Ibrahim

; Saraiva, Roberto Magalhães

; Oliveira Júnior, Wilson Alves de

; Lorga-Filho, Adalberto Menezes

; Guimarães, Adriana de Jesus Benevides de Almeida

; Braga, Adriana Lopes Latado

; Oliveira, Adriana Sarmento de

; Sarabanda, Alvaro Valentim Lima

; Pinto, Ana Yecê das Neves

; Carmo, Andre Assis Lopes do

; Schmidt, Andre

; Costa, Andréa Rodrigues da

; Ianni, Barbara Maria

; Markman Filho, Brivaldo

; Rochitte, Carlos Eduardo

; Macêdo, Carolina Thé

; Mady, Charles

; Chevillard, Christophe

; Virgens, Cláudio Marcelo Bittencourt das

; Castro, Cleudson Nery de

; Britto, Constança Felicia De Paoli de Carvalho

; Pisani, Cristiano

; Rassi, Daniela do Carmo

; Sobral Filho, Dário Celestino

; Almeida, Dirceu Rodrigues de

; Bocchi, Edimar Alcides

; Mesquita, Evandro Tinoco

; Mendes, Fernanda de Souza Nogueira Sardinha

; Gondim, Francisca Tatiana Pereira

; Silva, Gilberto Marcelo Sperandio da

; Peixoto, Giselle de Lima

; Lima, Gustavo Glotz de

; Veloso, Henrique Horta

; Moreira, Henrique Turin

; Lopes, Hugo Bellotti

; Pinto, Ibraim Masciarelli Francisco

; Ferreira, João Marcos Bemfica Barbosa

; Nunes, João Paulo Silva

; Barreto-Filho, José Augusto Soares

; Saraiva, José Francisco Kerr

; Lannes-Vieira, Joseli

; Oliveira, Joselina Luzia Menezes

; Armaganijan, Luciana Vidal

; Martins, Luiz Cláudio

; Sangenis, Luiz Henrique Conde

; Barbosa, Marco Paulo Tomaz

; Almeida-Santos, Marcos Antonio

; Simões, Marcos Vinicius

; Yasuda, Maria Aparecida Shikanai

; Moreira, Maria da Consolação Vieira

; Higuchi, Maria de Lourdes

; Monteiro, Maria Rita de Cassia Costa

; Mediano, Mauro Felippe Felix

; Lima, Mayara Maia

; Oliveira, Maykon Tavares de

; Romano, Minna Moreira Dias

; Araujo, Nadjar Nitz Silva Lociks de

; Medeiros, Paulo de Tarso Jorge

; Alves, Renato Vieira

; Teixeira, Ricardo Alkmim

; Pedrosa, Roberto Coury

; Aras Junior, Roque

; Torres, Rosalia Morais

; Povoa, Rui Manoel dos Santos

; Rassi, Sergio Gabriel

; Alves, Silvia Marinho Martins

; Tavares, Suelene Brito do Nascimento

; Palmeira, Swamy Lima

; Silva Júnior, Telêmaco Luiz da

; Rodrigues, Thiago da Rocha

; Madrini Junior, Vagner

; Brant, Veruska Maia da Costa

; Dutra, Walderez Ornelas

; Dias, João Carlos Pinto

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 6 elocation e20230269

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.36660/abc.20230269

Physical violence in children and adolescents: a retrospective study of injuries to the head and neck region adolescents
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Silveira, Isadora Augusta da

; Silva Neto, Tomaz Alves da

; Conceição, Luciana Domingues

; Nascimento, Gustavo Giacomelli

; Azevedo, Marina Sousa

; Lund, Rafael Guerra

Brazilian Journal of Oral Sciences

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2023, Volume 22 elocation e231486

Resumo: En | Texto: En | PDF: En

Aim This study aimed to investigate the prevalence of physical violence and head and neck injuries among children and adolescents who suffered physical aggression, firearm aggression, and white gun aggression referred to the Legal Medical Department in a southern city in Brazil. Methods This study was performed at Legal Medical Department in the city of Pelotas, RS, Brazil, from January 2011 to December of 2015. Data were collected from medical reports of children and adolescents (0-19 years old). Demographic information such as sex, age, and skin color was collected. Data were submitted to Chi-square test and multivariate Poisson regression analysis. Results In this study, 2,716 physical examination reports were analyzed, with a total of 2,171 exams resulting from violence; lesions that had physical aggression as their etiology (1,951) had a higher prevalence. The analysis of the exams revealed that the majority were adolescents (90,05%), white (84.09%), and female (50.21%). The head and neck regions were affected in most cases of violence (57.90%). In the adjusted model, the occurrence of injuries in the head and neck region was higher in males (PR 1.16, CI 95% 1.08 - 1.25), among adolescents (PR 1.28, CI 95% 1.10 - 1.48) and in victims of physical aggression compared to victims of the firearm (2.81, CI 95% 1.79 - 4.40). Conclusion The results revealed a high prevalence of head and face injuries in victims of violence and that there was a greater prevalence of physical violence among adolescents compared to children and males. Brazil Pelotas RS 201 2015 019 0 19 (0-1 old. old . old) sex age Chisquare Chi square 2716 2 716 2,71 analyzed 2171 171 2,17 1,951 1951 1 951 (1,951 90,05%, 9005 90,05% , 90 05 (90,05%) 84.09%, 8409 84.09% 84 09 (84.09%) 50.21%. 5021 50.21% 50 21 (50.21%) 57.90%. 5790 57.90% 57 (57.90%) model PR 116 16 1.16 95 108 08 1.0 1.25, 125 1.25 25 1.25) 128 28 1.28 110 10 1.1 1.48 148 48 2.81, 281 81 (2.81 179 79 1.7 4.40. 440 4.40 4 40 4.40) 20 01 (0- 271 71 2,7 217 17 2,1 1,95 195 (1,95 900 90,05 9 (90,05% 840 84.09 8 (84.09% 502 50.21 5 (50.21% 579 57.90 (57.90% 11 1. 12 1.2 1.4 14 2.81 (2.8 7 44 4.4 (0 27 2, 1,9 (1,9 90,0 (90,05 84.0 (84.09 50.2 (50.21 57.9 (57.90 2.8 (2. 4. ( 1, (1, 90, (90,0 84. (84.0 50. (50.2 57. (57.9 2. (2 (1 (90, (84. (50. (57. (90 (84 (50 (57 (9 (8 (5

https://doi.org/10.20396/bjos.v22i00.8671486

Saúde, cidadania e a pessoa idosa no contexto do velhismo
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Vilar, Rosana Lúcia Alves de

; Lima, Rafael Rodolfo Tomaz de

; Melo, Ricardo Henrique Vieira de

Revista Brasileira de Geriatria e Gerontologia

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2022, Volume 25 Nº 2 elocation e220097

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1981-22562022025.220097.pt

Death and dying of newborns and children: relationships between nursing and family according to Travelbee
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Medeiros, Jocellem Alves de

; Almeida Júnior, José Jailson de

; Oliveira, Luciane Paula Batista Araújo de

; Silva, Flávia Rayonara Santana da

; Silva, Clara Caroline dos Santos

; Barros, Wanessa Cristina Tomaz dos Santos

Revista Brasileira de Enfermagem

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2022, Volume 75 Nº 2 elocation e20210007

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Identificar a percepção da equipe de enfermagem sobre sua relação com familiares de neonatos e crianças que se encontram no processo de morte e morrer. Métodos: Pesquisa qualitativa, realizada em Unidade de Terapia Intensiva Neonatal e Pediatria de uma maternidade pública do Rio Grande do Norte, com 17 profissionais de enfermagem, mediante entrevista semiestruturada. Após transcritos, os dados foram submetidos à análise de conteúdo de Bardin e interpretados à luz da teoria das Relações Interpessoais proposta por Travelbee. Resultados: Quatro categorias emergiram da análise: "Cuidar e acolher pessoas, sentimentos e histórias"; "Reações em meio à dor: transitar entre a aceitação e o sofrimento"; "Comunicação de más notícias: desafios e estratégias"; "O peso do cuidar e do sofrer". Considerações finais: A assistência aos familiares pode ser estabelecida usando-se os princípios de Travelbee, pois oferecem aporte teórico oportuno para ações de enfermagem no contexto do processo de morte e morrer.

ABSTRACT Objective: Identify the nursing staff's perception of their relationship with families of newborns and children who are in the process of death and dying. Methods: Qualitative research, carried out in the Neonatal and Pediatric Intensive Care Unit of a public maternity hospital in Rio Grande do Norte, with 17 nursing professionals, through a semi-structured interview. After being transcribed, the data were subjected to Bardin's content analysis and interpreted in the light of the theory of Interpersonal Relations proposed by Travelbee. Results: Four categories emerged from the analysis: "Caring and welcoming people, feelings and stories"; "Reactions in the midst of pain: moving between acceptance and suffering"; "Communication of bad news: challenges and strategies"; "The weight of caring and suffering". Final considerations: Family assistance can be established using Travelbee's principles, as they offer timely theoretical support for nursing actions in the context of the process of death and dying.

RESUMEN Objetivo: Identificar la percepción del grupo de enfermería sobre su relación con familiares de neonatos y niños que se encuentran en el proceso de muerte y morir. Métodos: Investigación cualitativa, realizada en Unidades de Cuidado Intensivo Neonatal y Pediatría de una maternidad pública del Rio Grande do Norte, con 17 profesionales de enfermería, mediante entrevista semiestructurada. Tras transcritos, los datos fueron sometidos al análisis de contenido de Bardin e interpretados basados en la teoría de las Relaciones Interpersonales propuesta por Travelbee. Resultados: Del análisis, emergieron cuatro categorías: "Cuidar y acoger personas, sentimientos e historias"; "Reacciones en medio al dolor: transitar entre aceptación y sufrimiento"; "Comunicación de más noticias: desafíos y estrategias"; "El peso del cuidar y del sufrir". Consideraciones finales: La asistencia a los familiares puede ser establecida usándose los principios de Travelbee, pues ofrecen aporte teórico oportuno para acciones de enfermería en contexto del proceso de muerte y morir.

https://doi.org/10.1590/0034-7167-2021-0007 174 downloads

Cytotoxicity of Reparative Endodontic Cements on Human Periodontal Ligament Stem Cells
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Pedrosa, Marlus da Silva

; Alves, Tomaz

; Rahhal, Juliana Garuba

; Nogueira, Fernando Neves

; Sipert, Carla Renata

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2022, Volume 22 elocation e210114

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective To compare the cytotoxicity of commercial reparative endodontic cements on human periodontal ligament stem cells (hPDLSCs). Material and Methods The culture of hPDLSCs was established. Cell density was set at 2 × 104 cells/well in 96-well plates. Extracts of Biodentine, Bio-C Repair, Cimmo HD, MTA Repair HP and White MTA were prepared. Then, the extracts were diluted (pure, 1:4 and 1:16) and inserted into cell-seeded wells for 24, 48, and 72 h to assess cell viability through MTT assay. hPDLSCs incubated with culture medium alone served as a negative control group. Data were analyzed by Two-Way ANOVA and Tukey’s test (α=0.05). Results At 24 h, pure extract of MTA Repair HP and Biodentine 1:16 presented higher cell viability compared to control. Lower cell viability was found for pure extract of Cimmo HD, MTA Repair HP 1:4 and 1:16, and White MTA 1:16. At 48 h, pure extract of Bio-C Repair and MTA Repair HP presented higher cell viability compared to control. At 72 h, only the pure extract of MTA Repair HP led to higher cell proliferation compared to control. Conclusion Biodentine, Bio-C Repair and MTA Repair HP were able to induce hPDLSCs proliferation. Cimmo HD and White MTA were found to be mostly cytotoxic in hPDLSCs.

https://doi.org/10.1590/pboci.2022.004

10.

Effect of alpha-humulene incorporation on the properties of experimental light-cured periodontal dressings
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ROSSATO, Tharsis Christini de Almeida

; ALVES, Tomaz

; CUEVAS-SUÁREZ, Carlos Enrique

; ROSA, Wellington Luiz de Oliveira da

; SILVA, Adriana Fernandes da

; PIVA, Evandro

; ZANCHi, Cesar Henrique

; LUND, Rafael Guerra

Brazilian Oral Research

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2022, Volume 36 elocation e091

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to formulate an experimental light-cured periodontal dressing containing alpha-humulene and to compare its physical, antimicrobial, and cytotoxicity properties with commercial gold standards (Barricaid® and Periobond®). Two periodontal dressing formulations were developed (a and b). The formulations were divided into 5 groups according to the alpha-humulene concentration as follows: Ea - control group, Ea1 - 1%, Ea5 - 5%, Ea10 - 10%, and Ea20 - 20%; Eb - control group, Eb1 - 1%, Eb5 - 5%, Eb10 - 10%, and Eb20 - 20%. Materials characterization was performed using the degree of conversion, cohesive strength, sorption, and solubility assays. Antimicrobial assay was performed using the modified direct contact test against E. faecalis and S. aureus. Cytotoxicity was assessed by the cell viability experiment using L929 fibroblasts. In general, the cohesive strength values of materials decreased as the alpha-humulene concentration increased. All the experimental dressings showed antimicrobial activity against both bacteria tested. Cell viability results for the Ea, Ea1, Eb, and Eb1 groups showed moderate cytotoxic effect. The formulations containing alpha-humulene showed similar behavior to the commercial references. Thus, formulations containing alpha-humulene have potential to be used as periodontal dressing.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0091

11.

GASTROINTESTINAL STROMAL TUMOR: OUTCOMES OF THE PAST DECADE IN A REFERENCE INSTITUTION IN SOUTHERN BRAZIL
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EVERLING, Eduardo Morais

; MARCHET, Daniele

; DE-ANTONI, Natália Marchet

; ISBERT, Bruna Bley Mattar

; ALVES, Gustavo Vasconcelos

; GREZZANA-FILHO, Tomaz de Jesus Maria

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2022, Volume 35 elocation e1658

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO - RACIONAL: O Tumor estromal gastrointestinal (Gastrointestinal stromal tumor - GIST) é a neoplasia mesenquimal mais comum do trato digestivo, possui comportamento biológico variado e a principal forma de tratamento é a ressecção cirúrgica. OBJETIVO: analisar as características clínico-patológicas e a sobrevida de pacientes com GIST em uma instituição de referência para doenças oncológicas. MÉTODOS: Foi realizado um estudo observacional, longitudinal e retrospectivo de pacientes com diagnóstico de GIST de janeiro de 2011 a janeiro de 2020, analisando variáveis epidemiológicas e clínicas, estadiamento, ressecção cirúrgica, recidiva, uso de imatinibe e curvas de sobrevida global (SG) e sobrevida livre de doença (SLD). RESULTADOS: foram incluídos 38 pacientes, a maioria (58%) do sexo masculino, idade mediana de 62 anos. Os principais órgãos primários foram estômago (63%) e intestino delgado (17%). 24% tinham doença metastática ao diagnóstico. 76% receberam tratamento cirúrgico e 13% tratamento neoadjuvante. 47% dos pacientes receberam Imatinib como terapia adjuvante ou paliativa. A recorrência tumoral foi de 13%, mais comum no fígado. SG de 5 anos foi de 72,5% e SLD 47,1%. Os operados tiveram melhor SG (87,1% vs. 18,5%) e SLD (57,1% vs. 14,3%) em 5 anos. O tamanho do tumor igual ou maior que 5 cm não teve diferença na SG em 5 anos, mas SLD foi de 24,6%, em comparação com 92,3% dos tumores menores. Pacientes em terapia neoadjuvante e/ou em uso de imatinibe não apresentaram diferenças significativas. CONCLUSÕES: O tratamento cirúrgico com margens adequadas permite o melhor ganho de sobrevida, e o uso de Imatinibe em casos mais avançados tem equidade prognóstica com tumores em estágio menos avançado. O tratamento de tumores metastáticos parece promissor, necessitando de mais estudos.

ABSTRACT - BACKGROUND: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the digestive tract and has a wide variation in biological behavior; surgical resection remains the main form of treatment. AIM: This study aimed to analyze clinicopathological characteristics and survival of patients with GIST in a reference institution for oncological diseases. METHODS: An observational, longitudinal, and retrospective study of patients diagnosed with GIST from January 2011 to January 2020 was carried out by analyzing epidemiological and clinical variables, staging, surgical resection, recurrence, use of imatinib, and curves of overall survival (OS) and disease-free survival (DFS). RESULTS: A total of 38 patients were included. The majority (58%) of patients were males and the median age was 62 years. The primary organs that were affected by this tumor were stomach (63%) and small intestine (17%). Notably, 24% of patients had metastatic disease at diagnosis; 76% of patients received surgical treatment and 13% received neoadjuvant treatment; and 47% of patients received imatinib as adjuvant or palliative therapy. Tumor recurrence was 13%, being more common in the liver. The 5-year OS was 72.5% and DFS was 47.1%. The operated ones had better OS (87.1% vs. 18.5%) and DFS (57.1% vs. 14.3%) in 5 years. Tumor size ≥5 cm had no difference in OS at 5 years, but DFS was 24.6%, when compared with 92.3% of smaller tumors. Patients who were undergoing neoadjuvant therapy and/or using imatinib did not show any significant differences. CONCLUSIONS: Surgical treatment with adequate margins allows the best gain in survival, and the use of imatinib in more advanced cases has prognostic equity with less advanced-stage tumors. Treatment of metastatic tumors seems promising, requiring further studies.

https://doi.org/10.1590/0102-672020210002e1658

12.

Protease-activated receptor type 1 (PAR1) increases CEMP1 gene expression through MAPK/ERK pathway
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Rovai, Emanuel Silva

; Alves, Tomaz

; Gasparoni, Letícia Miquelitto

; França, Bruno Nunes de

; Sipert, Carla Renata

; Kantarci, Alpdogan

; Holzhausen, Marinella

Brazilian Oral Research

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2022, Volume 36 elocation e048

Resumo: En | Texto: En | PDF: En

Abstract: PAR1 is a G-coupled protein receptor that regulates several cellular metabolism processes, including differentiation and proliferation of osteogenic and cementogenic related cells and our group previously demonstrated the regenerative potential of PAR1 in human periodontal ligament stem cells (hPDLSCs). In this study, we hypothesized that PAR1 regulates the cementogenic differentiation of hPDLSCs. Our goal was to identify the intracellular signaling pathway underlying PAR1 activation in hPDSLC differentiation. hPDLSCs were isolated using the explant technique. Cells were cultured in an osteogenic medium (OST) (α-MEM, 15% fetal bovine serum, L-glutamine, penicillin, streptomycin, amphotericin B, dexamethasone, and beta-glycerophosphate). The hPDLSCs were treated with a specific activator of PAR1 (PAR1 agonist) and blockers of the MAPK/ERK and PI3K pathways for 2 and 7 days. The gene expression of CEMP1 was assessed by RT-qPCR. The activation of PAR1 by its agonist peptide led to an increase in CEMP1 gene expression when compared with OST control. MAPK/ERK blockage abrogated the upregulation of CEMP1 gene expression induced by PAR1 agonist (p < 0.05). PI3K blockage did not affect the gene expression of CEMP1 at any experimental time (p > 0.05). We concluded that CEMP1 gene expression increased by PAR1 activation is MAPK/ERK-dependent and PI3K independent, suggesting that PAR1 may regulate cementogenetic differentiation of hPDLSCs.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0048

13.

Cytotoxicity and cytokine production by calcium silicate-based materials on periodontal ligament stem cells
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Pedrosa, Marlus da Silva

; Alves, Tomaz

; Nogueira, Fernando Neves

; Holzhausen, Marinella

; Sipert, Carla Renata

Brazilian Dental Journal

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Jun 2021, Volume 32 Nº 3 Páginas 65 - 74

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este estudo investigou o efeito de três materiais comerciais à base de silicato de cálcio (CSBM) na citotoxicidade e na produção de citocinas pró e antiinflamatórias em células-tronco do ligamento periodontal humano (hPDLSCs). Cultura de hPDLSCs foi estabelecida e caracterizada. Extratos de Bio-C Sealer (Angelus, Londrina, PR, Brasil), MTA Fillapex (Angelus, Londrina, PR, Brasil) e PBS Cimmo HP® (Cimmo Soluções em Saúde, Pouso Alegre, MG, Brasil) foram preparados com a colocação de espécimes dos cimentos (5 x 3 mm) em meio de cultura. Em seguida, os extratos foram diluídos (1, 1: 2, 1: 4, 1: 8, 1:16) e inseridos nos poços semeados de células para ensaio de citotoxicidade por meio de MTT por 24, 48 e 72 h. As citocinas TNF-α e IL-10 foram quantificadas por ELISA em sobrenadantes de células de 24 h. Os dados foram analisados por ANOVA e teste de Tukey (α = 0,05). Todos os CSBM exibiram alguma citotoxicidade que variou de acordo com a concentração do extrato e o tempo de avaliação. O MTA Fillapex apresentou os maiores efeitos citotóxicos com redução significativa da atividade metabólica / viabilidade celular quando comparado ao Bio-C Sealer e Cimmo HP®. O TNF-α foi regulado positivamente pelos três cimentos testados (p <0,05), enquanto apenas o MTA Fillapex regulou positivamente a liberação de IL-10 em comparação com o controle. Tomados em conjunto, os resultados mostraram que PBS Cimmo HP®, Bio-C Sealer e MTA Fillapex apresentam citotoxicidade leve e transitória e induziram a produção de TNF-α. O MTA Fillapex regulou positivamente a liberação de IL-10 por hPDLSCs.

Abstract This study investigated the effect of three commercial calcium silicate-based materials (CSBM) on cytotoxicity and pro-and anti-inflammatory cytokines production in cultured human periodontal ligament stem cells (hPDLSCs). Culture of hPDLSCs was established and characterized. Extracts of Bio-C Sealer (Angelus, Londrina, PR, Brazil), MTA Fillapex (Angelus, Londrina, PR, Brazil) and PBS Cimmo HP (Cimmo Soluções em Saúde, Pouso Alegre, MG, Brazil) were prepared by placing cement specimens (5 x 3 mm) in culture medium. Then, the extracts were serially two-fold diluted (1, 1:2, 1:4, 1:8, 1:16) and inserted into the cell-seeded wells for 24, 48 and 72 h for MTT assays. TNF-α and IL-10 cytokines were quantified by ELISA at 24h-cell supernatants. Data were analyzed by ANOVA and Tukey’s test (α = 0.05). All CSBM exhibited some cytotoxicity that varied according to extract concentration and time of evaluation. MTA Fillapex presented the highest cytotoxic effects with significant reduction of metabolic activity/cell viability when compared to Bio-C Sealer and Cimmo HP®. TNF-α was significantly upregulated by the three tested cements (p < 0.05) while only MTA Fillapex significantly upregulated IL-10 in comparison to control. Taken collectively, the results showed that PBS Cimmo HP®, Bio-C Sealer and MTA Fillapex present mild and transient cytotoxicity and slightly induced TNF-α production. MTA Fillapex upregulated IL-10 release by hPDLSCs.

https://doi.org/10.1590/0103-6440202104467 38 downloads

14.

UENF WS01: popcorn hybrid with water use efficiency for the State of Rio de Janeiro
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Lima, Valter Jário de

; Amaral Júnior, Antônio Teixeira do

; Kamphorst, Samuel Henrique

; Santos, Adriano dos

; Schmidt, Katia Fabiane Medeiros

; Azeredo, Valdinei Cruz

; Leite, Jhean Torres

; Santos Junior, Divino Rosa dos

; Santos, Talles de Oliveira

; Bispo, Rosimeire Barboza

; Carvalho, Carolina Macedo

; Souza, Yure Pequeno de

; Oliveira, Fabio Tomaz de

; Chaves, Marcelo Moura

; Oliveira, Uéliton Alves de

; Mafra, Gabrielle Sousa

; Santos, Pedro Henrique Araújo Diniz

Crop Breeding and Applied Biotechnology

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2021, Volume 21 Nº 4 elocation e375821411

Resumo: En | Texto: En | PDF: En

Abstract The UENF WS01 is a hybrid that has an early cycle and high grain yield capacity under low water and nitrogen availability. It maintains popping expansion even under abiotic stress, thus being recommended for cultivation in the North and Northwest of the State of Rio de Janeiro.

https://doi.org/10.1590/1984-70332021v21n4c60

15.

A Redução do Colágeno Tipo I está Associada ao Aumento da Atividade da Metaloproteinase-2 e da Expressão Proteica de Leptina no Miocárdio de Ratos Obesos
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Silva-Bertani, Danielle Cristina Tomaz da

; Vileigas, Danielle Fernandes

; Mota, Gustavo Augusto Ferreira

; Souza, Sérgio Luiz Borges de

; Tomasi, Loreta Casquel De

; Campos, Dijon Henrique Salomé de

; Deus, Adriana Fernandes de

; Freire, Paula Paccielli

; Alves, Carlos Augusto Barnabe

; Padovani, Carlos Roberto

; Cicogna, Antonio Carlos

Arquivos Brasileiros de Cardiologia

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Jul 2020, Volume 115 Nº 1 Páginas 61 - 70

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A obesidade é um fator de risco para complicações médicas, incluindo o sistema cardiovascular. Há informações limitadas sobre o colágeno no coração obeso. Nosso estudo anterior demonstrou uma redução dos níveis proteicos de colágeno miocárdico tipo I em ratos obesos alimentados com uma dieta com alto teor de gordura durante 34 semanas. No entanto, os mecanismos responsáveis pelos níveis baixos não estão completamente elucidados. Objetivo O objetivo deste estudo foi testar a hipótese de que a redução do colágeno tipo I está associada ao aumento da atividade da metaloproteinase-2 (MMP-2), a qual está ligada à elevação de leptina no miocárdio de ratos obesos. Métodos Ratos Wistar machos com 30 dias de idade foram randomizados em dois grupos: controle (dieta padrão) e obeso (dieta com alto teor de gordura), e alimentados durante 34 semanas. Foram avaliados as características gerais dos animais e os perfis metabólicos e endócrinos. Foram avaliados as expressões proteicas miocárdicas de colágeno tipo I, leptina e inibidores teciduais de metaloproteinases (TIMP), bem como a atividade da MMP-2. O teste de correlação de Pearson foi aplicado para determinar as associações entre variáveis. O nível de significância foi de 5%. Resultados Os animais obesos apresentaram índice de adiposidade mais elevado em comparação ao controle. Foram observadas comorbidades como intolerância à glicose, hiperinsulinemia, resistência à insulina, hiperleptinemia e hipertensão nos ratos obesos. A obesidade reduziu o colágeno tipo I, TIMP-1 e TIMP-2, e aumentou a leptina e a MMP-2 no miocárdio. Houve uma correlação negativa entre o colágeno tipo I e a MMP-2 e uma correlação positiva entre a leptina e a MMP-2. Conclusão Foi confirmada a hipótese de que a redução do colágeno tipo I está associada ao aumento da atividade da MMP-2 e da expressão de leptina no miocárdio de ratos obesos. (Arq Bras Cardiol. 2020; 115(1):61-70)

Abstract Background Obesity is a risk factor for medical complications, including the cardiovascular system. There is limited information on collagen in the heart in obesity. Our previous study showed decreased protein levels of myocardial collagen type I in obese rats fed a high-fat diet for 34 weeks. However, the mechanisms responsible for low levels are not fully elucidated. Objective The purpose of this study was to test the hypothesis that the reduction in collagen type I is associated with increased metalloproteinase-2 (MMP-2) activity, which is linked to elevated leptin in the myocardium of obese rats. Methods Thirty-day-old male Wistar rats were randomized into two groups, control (standard diet) and obese (high-fat diet), and fed for 34 weeks. The general animal characteristics and metabolic and endocrine profiles were evaluated. Myocardial protein expressions of collagen I, leptin, tissue inhibitors of metalloproteinases (TIMP), and MMP-2 activity were assessed. Pearson correlation was employed to determine the associations between variables. The level of significance was 5%. Results The obese animals had increased adiposity index compared to control. Comorbidities such as glucose intolerance, hyperinsulinemia, insulin resistance, hyperleptinemia, and hypertension were observed in obese rats. Obesity reduced collagen I, TIMP-1, and TIMP-2, and it increased leptin and MMP-2 in the myocardium. There was a negative correlation between collagen I and MMP-2 and a positive correlation between leptin and MMP-2. Conclusion The hypothesis was confirmed; the reduction in collagen type I is associated with increased MMP-2 activity and leptin expression in the myocardium of obese rats. (Arq Bras Cardiol. 2020; 115(1):61-70)

https://doi.org/10.36660/abc.20180143 1032 downloads

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