SUMMARY A 71-year-old woman with recurrent papillary thyroid carcinoma (PTC) was referred to our hospital. A computed tomography scan revealed extensive recurrence in the neck, invading sternocleidomastoid muscle, internal jugular vein, sternal end of the clavicle, strap muscle and skin; and lateral compartment and subclavian lymph nodes were also involved. Multiple pulmonary micrometastases also noticed. The tumor was considered unresectable; however, the patient was unwilling to accept highly invasive surgery. Therefore, we initiated neoadjuvant therapy with anlotinib, 12mg p.o. daily with a 2-week on/1-week off regimen. The tumor shrunk to resectable state after 4 cycles of treatment, and after 3 weeks of withdrawal, successful surgical resection without gross tumor residual was performed. Pathology confirmed as classic PTC harboring coexistent TERT promoter and BRAFV600E mutations by NGS. After anlotinib therapy, apoptosis induction was observed, and proliferation increased, which was due to three weeks of anlotinib withdraw. Structual recurrence was recorded at 6 months after operation due to no further treatment was taken. Our finding suggests that anlotinib could represent as a good treatment option for patients with locally advanced (with or without distant metastasis) PTC; Anlotinib treatment resulted in sufficient reduction of the tumor mass to enable total thyroidectomy and radioactive iodine treatment, providing long-term control of the disease. 71yearold yearold 71 year old (PTC hospital neck vein clavicle skin involved noticed unresectable however surgery Therefore mg po p o p.o 2week week 2 on/1week on1week onweek on/1 on 1 regimen withdrawal performed BRAFVE BRAFV E NGS observed increased withdraw taken metastasis longterm long term disease 7 1week on1 on/

Ideological and political education in universities focuses on cultivating people's good psychological qualities and regards positive psychology as an important entry point for the construction of ideological and political culture. This will provide new ideas for the reform and innovation of modern education. This study selected 300 students from six universities as the research subjects and analysed the impact of ideological and political cultural construction on students' psychological quality from the perspective of positive psychology. The Psychological Scale (SAS) is used to reflect the impact of ideological, political, and cultural construction on students' psychological activities. The results indicate that from the perspective of positive psychology, the construction of ideological and political culture among college students has a significant improvement effect on various psychological indicators of students. CONTRIBUTION: The construction of ideological and political culture in colleges and universities faces social factors, teaching factors and personal factors, which have an adverse impact on the formation of students' psychological quality. This study in order to better evaluate the improvement of psychological indicators, take positive psychology as an entry point, and take necessary teaching measures to promote the formation of students' good psychological quality. This research represents data that can be used by scholars in the field of religious education and public theology

RESUMO Introdução Com o desenvolvimento contínuo do basquetebol universitário, cada vez mais estudantes universitários aderem ao esporte e as lesões esportivas resultantes também tem aumentado gradualmente, afetando a qualidade de vida e o desempenho nos estudos. Objetivo Analisar as lesões esportivas mais comuns e oferecer soluções visando a prática segura do basquetebol universitário. Métodos Este artigo estuda por meio de entrevistas e revisão literária as lesões no basquetebol dos estudantes universitários, analisa as principais causas das lesões no esporte e apresenta as contramedidas correspondentes para promover o desenvolvimento seguro do ensino esportivo em faculdades. Resultados As principais lesões encontradas foram durante o treino, excesso de força e preparo inadequado. O trabalho muscular deficitário também está associado a maior parte dessas lesões. Conclusão O basquetebol é um esporte altamente competitivo, muito popular nos campi universitários. É um esporte que pode exercitar e enriquecer a vida extracurricular dos estudantes universitários, requerendo de seus praticantes uma maior atenção na fase de aquecimento pré-treino e fortalecimento muscular paralelo para redução das suas principais lesões em universitários. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

ABSTRACT Introduction As college basketball continues to develop, more and more college students are joining the sport, and the resulting sports injuries have also gradually increased, affecting the quality of life and academic performance. Objective Analyze the most common sports injuries and offer solutions for the safe practice of college basketball. Methods This article studies, through interviews and literature review, the basketball injuries of college students, analyze the main causes of sports injuries, and presents corresponding countermeasures to promote the safe development of sports education in colleges. Results The main injuries were during training, excessive force, and inadequate preparation. Deficient muscle work is also associated with most of these injuries. Conclusion Basketball is highly competitive and popular on college campuses. It is a sport that can exercise and enrich the extracurricular life of college students, requiring from its practitioners greater attention in the pre-training warm-up phase and parallel muscle strengthening to reduce its major injuries in college students. Level of evidence II; Therapeutic studies - investigation of treatment outcomes

RESUMEN Introducción Con el continuo desarrollo del baloncesto universitario, cada vez más estudiantes universitarios se incorporan a este deporte y las lesiones deportivas resultantes también han aumentado gradualmente, afectando a la calidad de vida y al rendimiento en los estudios. Objetivo Analizar las lesiones deportivas más comunes y ofrecer soluciones orientadas a la práctica segura del baloncesto universitario. Métodos Este artículo estudia, mediante entrevistas y revisión de la literatura, las lesiones de baloncesto de los estudiantes universitarios, analiza las principales causas de las lesiones deportivas y presenta las correspondientes contramedidas para promover el desarrollo seguro de la enseñanza deportiva en los colegios. Resultados Las principales lesiones encontradas fueron durante el entrenamiento, la fuerza excesiva y la preparación inadecuada. El trabajo muscular deficiente también está asociado a la mayoría de estas lesiones. Conclusión El baloncesto es un deporte altamente competitivo, muy popular en los campus universitarios. Es un deporte que puede ejercitar y enriquecer la vida extraescolar de los universitarios, requiriendo de sus practicantes una mayor atención en la fase de calentamiento previo al entrenamiento y el fortalecimiento muscular paralelo para reducir sus principales lesiones en los universitarios. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

SUMMARY OBJECTIVE: This study aimed to investigate the suboptimal health status or subhealth status and their relationship with mental health and smartphone addiction among Chinese medical students. METHODS: A cross-sectional survey was conducted at Wannan Medical College of China in Wuhu. RESULTS: A total of 2,741 students were surveyed in October 2020. Of 2,741 Chinese medical students who completed the survey, 904 (33%) participants reported to have had subhealth status. Anxiety status (p<0.001), depression status (p<0.001), and smartphone addiction status (p<0.001) have strong association with subhealth status. CONCLUSION: This survey shows that the detection rate of subhealth status in Chinese medical students was 33%. Anxiety, depression, and smartphone addiction students had a higher detection rate of subhealth status. The anxiety, depression, and smartphone addiction of Chinese medical students are associated with subhealth status. OBJECTIVE METHODS crosssectional cross sectional Wuhu RESULTS 2741 2 741 2,74 2020 90 33% 33 (33% p<0.001, p0001 p p<0.001 , 0 001 (p<0.001 CONCLUSION anxiety 274 74 2,7 202 9 3 (33 p000 p<0.00 00 (p<0.00 27 7 2, 20 (3 p00 p<0.0 (p<0.0 ( p0 p<0. (p<0. p<0 (p<0 p< (p< (p

SUMMARY OBJECTIVE: This study aimed to assess the attitudes of Chinese residents toward COVID-19 vaccines and explore the potential drivers for Chinese residents' vaccine hesitancy. METHODS: A cross-sectional survey was conducted from February 16 to March 16, 2021, by administering an online questionnaire to the Chinese residents. RESULTS: Of 5240 residents who completed the survey, 464 (8.9%) participants reported to have had one shot, and 348 (6.6%) reported to have had 2 shots. At the time the questionnaire was administered, 2298 (43.9%) participants reported they wanted to get vaccinated, while 2255 (43.0%) declared that they still did not know, and 687 (13.1%) respondents declared vaccine refusal. Overall, 2255 (43%) participants were categorized as vaccine hesitancy. Female participants (p=0.000), <20 years old (p=0.000), have low risk of COVID-19 (p=0.000) infection and strong associations of vaccine hesitancy. eHealth literacy was a protective factor. CONCLUSIONS: The results of this study show high rates of vaccine hesitancy in China. This could pose a serious threat to the preventive measures that aimed at controlling COVID-19 spread in the country. The government and different media platforms should encourage the dissemination of correct information about vaccines, the communities and medical staff to improve residents' knowledge about vaccines, and strive to improve residents' electronic health literacy.

Abstract Ginkgo biloba leaves are commonly used in traditional Chinese medicine. Owing to its wide distribution across China with varying geographical environments and climatic characteristics, G. biloba leaf products have different active ingredients and degrees of activities, which poses a challenge for quality control and standardization. We aimed to identify the key factors contributing to the quality of G. biloba based on assessment of anti-aging and antioxidative components. G. biloba leaf samples collected from 14 different regions in China were analyzed for antioxidant activities by the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging assay, and the levels of terpene lactones and flavonoids were quantified by ultra-performance liquid chromatography-tandem mass spectroscopy and high performance liquid chromatography. Correlation analysis attributed the antioxidant activity of G. biloba leaf samples of different origins to isoginkgetin and ginkgetin, which also affected the matrix metalloproteinase-1 levels of fibroblasts, determined using enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction. Therefore, appropriate quality control of a collected G. biloba sample could be achieved by determining the levels of isoginkgetin and ginkgetin as anti-aging and antioxidant components. The results further provide a foundation for the application of G. biloba leaves as an antioxidant raw material.

This study aimed to evaluate the feasibility and repeatability of the flash-replenishment method in contrast-enhanced ultrasound (CEUS) perfusion imaging and assess quantitatively microvascular perfusion in the liver. Twenty healthy New Zealand rabbits were submitted to CEUS perfusion imaging with continuous intravenous infusion. Using flash-replenishment kinetics, the dynamic process of depletion and refilling of microbubble contrast agent was recorded. The hepatic microvascular perfusion parameters were calculated, including region of interest, peak intensity (PI), area under the curve (AUC), and hepatic artery to vein transit time (HA-HVTT). A consistency test was performed for multiple measurements by the same operator and blind measurements by two different operators. The hepatic perfusion imaging of 3×108 bubbles/min had minimal error and the best imaging effect and repeatability. The variability of the perfusion parameter measured at 3 cm depth under the liver capsule was at a minimum with coefficient of variation of 3.9%. The interclass correlation coefficient (ICC) of measurements taken by the same operator was 0.985, (95% confidence interval, CI=0.927-0.998). Measurements taken by two operators had good consistency and reliability, with the ICC of 0.948 (95%CI=0.853-0.982). The PI and AUC of liver parenchyma after reperfusion were lower than before blocking; and HA-HVTT was significantly longer than before blocking (P<0.05). The flash-replenishment method in CEUS perfusion imaging showed good stability and repeatability, which provide a valuable experimental basis for the quantitative assessment of hepatic microvascular perfusion in clinical practice.

South Africa has become one of the most developing countries in the world, and its economic growth has occurred along with rising energy-related CO2 emission levels. A deeper understanding of the driving forces governing energy-related CO2 emissions is very important in formulating future policies. The LMDI (Log Mean Divisia Index) method is used to analyse the contribution of the factors which influence energy-related CO2 emissions in South Africa over the period 1993-2011. The main conclusions drawn from the present study may be summarized as follows: the energy intensity effect plays the dominant role in decreasing of CO2 emission, followed by fossil energy structure effect and renewable energy structure effect; the economic activity is a critical factor in the growth of energy-related CO2 emission in South Africa.

The purpose of this paper is to apply the decoupling index combined with the LMDI method to analyze the contribution of the factors which influence electricity consumption in China over the period 19912009. The main results are as follows: (1) Electricity consumption has been rising year by year with economic growth. Electricity consumption came to 427.37 Mtce in 2009, which accounted for 19.56% of total energy consumption. (2) China's electricity intensity has continuously decreased during the 1990s and early 2000s, the decreasing trend has reserved since 2003. (3) The economic activity effect is the most important contributor to increase electricity consumption in China, the sector electricity share effect is another important factor leading to the rapid growth of electricity and the energy intensity effect plays the dominant role in decreasing electricity consumption. (4) The period from 1999 to 2007 represents a re-coupling effect, while the other time interval shows weak decoupling effect.

The esterification of salicylic acid with methanol was carried out over a series of Ce4+modified cation-exchange resins. The effect of different reaction conditions was studied on the conversion of salicylic acid, and the optimal reaction parameters were obtained. The experimental results indicated that Ce(SC^A)Olx7 was an effective catalyst for the synthesis of methyl salicylate. The conversion of salicylic acid could reach 93.3% while its selectivity was more than 99.0%. SEM-EDS and TG-DSC analysis were employed to characterize the structure and property of the catalyst. Besides, the catalytic performance of Ce(SC^A)Olx7 in the esterification of salicylic acid with different alcohols was compared. The reusability of Ce(SC^A)Olx7 was also studied by using salicylic acid and methanol as model substrates. The mechanism was proposed for the esterification of salicylic acid with methanol over Ce4+modified cation-exchange resins.