A series of biologically active N-acylamino amides were synthesized from readily available amino acids and common fatty acids from oil seeds, including the pharmacophoric group in the family of herbicides propanil, linuron, and diuron. The esterification followed by N-acylation with long-chain fatty acids was carried out with O-(benzotriazole-1-yl)-N,N,N’,N’-tetramethyluronium tetrafluoroborate (TBTU) as activating agent. The N-acylamino esters were synthesized and isolated in good yields (70-98%), which after the hydrolysis step, provided the N-acylamino acids. Finally, new N-acylamino amides were obtained from the reaction with 3,4-dichloroaniline in the presence of TBTU and N,N-diisopropylethylamine (DIPEA), in yields between 24-83%. Bioassays were conducted against arthropod strawberry pests Chaetosiphon fragaefolii, Duponchelia fovealis, and Drosophila suzukii, without any registered compound for use in strawberry crops in Brazil. The bioassay studies showed promising results, with mortality percentages ranging from 20-80%, and the best relative mortality by N-oleyl glycinamide, suggesting a possible fatty chain-amino acid synergistic bioactivity. Overall, this study provides an efficient and sustainable method for synthesizing biologically active N-acylamino amides from abundant natural sources, with potential applications in the development of ecofriendly agrochemicals. Nacylamino N acylamino seeds propanil linuron diuron Nacylation acylation longchain long chain Obenzotriazole1ylN,N,N,Ntetramethyluronium Obenzotriazole1ylNNNNtetramethyluronium ObenzotriazoleylNNNNtetramethyluronium O benzotriazole 1 yl N,N,N ,N tetramethyluronium (TBTU agent 7098%, 7098 70 98% , 98 (70-98%) step Finally 3,4dichloroaniline 34dichloroaniline dichloroaniline 3,4 3 4 N,Ndiisopropylethylamine NNdiisopropylethylamine N,N diisopropylethylamine DIPEA, DIPEA (DIPEA) 2483%. 2483 24 83%. 83 24-83% fragaefolii fovealis suzukii Brazil results 2080%, 2080 20 80%, 80 20-80% Noleyl oleyl glycinamide chainamino bioactivity Overall sources agrochemicals Obenzotriazole1ylN Ntetramethyluronium Obenzotriazole ylN ylNNNNtetramethyluronium NNN 7098% 709 7 9 (70-98% 4dichloroaniline 34 3, Ndiisopropylethylamine NN (DIPEA 2483% 248 2 83% 8 24-83 2080% 208 80% 20-80 ObenzotriazoleylN (70-98 24-8 20-8 (70-9 24- 20- (70- (70 (7 (

Paecilomyces lilacinus apresenta potencial para controle de pragas. O objetivo deste trabalho foi analisar o crescimento micelial e a produção de esporos de linhagens de P. lilacinus em resíduos agro-industriais e meios comerciais. Este estudo sugere fontes alternativas para produção de fungos com potencial biotecnológico para desenvolvimento de bioprodutos.

Paecilomyces lilacinus has potential for pests control. We aimed to analyze mycelial growth and spore production in P. lilacinus strains in several agro-industrial residues and commercial media. This study suggests alternative nutrient sources for fungi production and that the biotechnological potential of agro-industrial refuses could be employed in byproducts development.