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ABSTRACT Purpose: This work aimed to investigate the effects of Tanshinone IIA (Tan IIA) on myocardial cell (MC) apoptosis in a rat model of heart failure (HF). Methods: Tan IIA was extracted from Salvia miltiorrhiza Bunge (SMB) using an ethanol reflux method. Fifty rats were randomly divided into five groups: sham (no treatment), mod (HF model establishment), low dose (LD: 0.1 mL/kg Tan IIA), medium dose (MD: 0.3 mL/kg Tan IIA), and high dose (HD: 0.5 mL/kg Tan IIA), with 10 rats in each group. The effects of different doses of Tan IIA on cardiac function, MC apoptosis, and the levels of proteins associated with the PI3K/Akt/mTOR signaling pathway were compared. Results: Mod group showed a significant decrease in systolic arterial pressure, mean arterial pressure, heart rate, left ventricular systolic pressure, left ventricular ejection fraction, left ventricular fractional shortening, and the levels of p-PI3K, p-Akt, and p-mTOR proteins versus sham group (p < 0.05). Additionally, the left ventricular end-diastolic diameter (LVIDd), end-systolic diameter, diastolic pressure, and MC apoptosis were significantly increased (p < 0.05). LD, MD, and HD groups exhibited significant improvements across various indicators of cardiac function and MC apoptosis versus mod group (p < 0.05). Conclusions: Tan IIA may improve cardiac function and inhibit MC apoptosis in rats with HF by modulating the PI3K/Akt/mTOR signaling pathway. Purpose (MC HF. . (HF) Methods SMB (SMB method no treatment, treatment , treatment) establishment, establishment establishment) LD (LD 01 0 1 0. mLkg mL kg IIA, MD (MD 03 3 (HD 05 5 PI3KAktmTOR PIKAktmTOR PI3K Akt mTOR PI K compared Results pressure rate fraction shortening pPI3K, pPI3K pPIK p PI3K, p-PI3K pAkt, pAkt Akt, p-Akt pmTOR 0.05. 005 0.05 0.05) Additionally enddiastolic end LVIDd, LVIDd (LVIDd) endsystolic Conclusions KAktmTOR PIK pPI 00 0.0 (LVIDd