Abstract Objective: Emergence delirium is a common complication in children. Recorded mother’s voice, as a non-pharmacological measure, is increasingly used to prevent the emergence of delirium in pediatric patients, but sufficient evidence is still needed to prove its efficacy. Methods: Embase, PubMed, Cochrane Library, Web of Science, CINAHL, and Sinomed databases were searched for randomized controlled trials exploring the efficacy of recorded mother’s voice in preventing the emergence of delirium in pediatric patients undergoing general anesthesia. The original data were pooled for the meta-analysis with Review Manager 5.4.1. This study was conducted based on the Cochrane Review Methods. Results: Eight studies with 724 children were included in the analysis. Recorded mother’s voice reduced the incidence of emergence delirium when compared with either no voice (RR: 0.45; [95 % CI, 0.34 - 0.61]; p < 0.01; I2 = 7 %) or stranger’s voice (RR: 0.51; [95 % CI, 0.28 - 0.91]; p = 0.02; I2 = 38 %) without increasing other untoward reactions. In addition, it shortened the post-anesthesia care unit stay time when compared with no voice (MD = -5.64; [95 % CI, -8.43 to -2.58]; p < 0.01, I2 = 0 %), but not stranger’s voice (MD = -1.23; [95 % CI, -3.08 to 0.63]; p = 0.19, I2 = 0 %). It also shortened the extubation time and reduced the incidence of postoperative rescue analgesia. Conclusion: The current analysis indicated that recorded mother’s voices could reduce the incidence of emergency delirium, shorten post-anesthesia care unit stay time and extubation time, and decrease the incidence of postoperative rescue analgesia in children. Objective mothers mother s nonpharmacological non pharmacological measure Methods Embase PubMed Library Science CINAHL anesthesia metaanalysis meta 541 5 4 1 5.4.1 Results 72 RR (RR 0.45 045 45 95 [9 CI 034 34 0.3 0.61 061 61 0.61] 0.01 001 01 I strangers stranger 0.51 051 51 028 28 0.2 0.91 091 91 0.91] 0.02 002 02 3 reactions addition postanesthesia post MD 5.64 564 64 -5.64 8.43 843 8 43 -8.4 2.58 258 2 58 -2.58] %, , 1.23 123 23 -1.23 3.08 308 08 -3.0 0.63 063 63 0.63] 019 19 0.19 %. . Conclusion 54 5.4. 0.4 04 9 [ 03 0. 0.6 06 6 0.0 00 0.5 05 0.9 09 5.6 56 -5.6 8.4 84 -8. 2.5 25 -2.58 1.2 12 -1.2 3.0 30 -3. 0.1 5.4 5. -5. 8. -8 2. -2.5 1. -1. 3. -3 -5 -2. -1 -2

Abstract To investigate the characteristics of heart rate variability in patients with Crohn’s disease (CD) and the relationship between HRV parameters and inflammatory activity. Background: CD is a chronic inflammatory granuloma disease of the digestive tract. A total of 37 patients with CD and 39 age- and gender-matched healthy controls were enrolled. Demographic information, medication, and medical history were collected from questionnaires completed by all participants. HRV parameters was recorded by 5 min short-term heart rate variability analyzer. Inflammatory factors, Crohn’s disease activity index (CDAI), and anxiety and depression were assessed. The mean autonomic nerve function score was 72 in CD group, significantly lower than that in control group (75, P < 0.05). The equilibrium in CD group was strongly lower than that in control group (P = 0.001). CD subjects had lower autonomic nervous function compared with controls, which positively correlated with body mass index. Equilibrium was significantly lower among CD subjects, which negatively correlated with inflammatory markers C reactive protein and platelet count. Autonomic dysfunction was observed in CD subjects, mainly manifested as decreased equilibrium, which this inherent imbalance of autonomic function associated with active inflammation.