Abstract The objective was to evaluate the spatial distribution of chemical and textural soil variables in a multistrata agroforestry system. A total of 73 georeferenced soil samples were collected at depths of 10-20 cm and 20-40 cm. The studied parameters were: pH H2O , potential acidity (H+Al), calcium (Ca 2+ ), magnesium (Mg 2+ ), aluminum (Al 3+ ), sodium (Na + ), potassium (K + ), phosphorus (P), organic carbon (C org ), cation exchange capacity (T-value), base saturation (V-value), total clay, total sand, and silt. Principal component analysis (PCA) was performed in R software using the FactoMineR and Factoextra packages. For variables with spatial dependence, ordinary kriging was performed using the best-fitted model. For variables without spatial dependence, inverse distance weighted (IDW) interpolation was applied (power = 2). The spherical model was the best fit for chemical attributes. IDW interpolation accurately mapped the textural attributes. It was concluded that geostatistics enabled a detailed analysis of chemical and textural attributes. system 7 1020 10 20 10-2 2040 40 20-4 HO H O H+Al, HAl H+Al Al (H+Al) Ca 2 ) Mg 3 Na K P, P (P) C Tvalue, Tvalue T value (T-value) Vvalue, Vvalue V (V-value) clay sand silt PCA (PCA packages dependence bestfitted fitted (IDW power 2. . 2) attributes 102 1 10- 204 4 20- (H+Al (P (T-value (V-value

Abstract The objective of this study was to evaluate the classification of productive capacity in eucalyptus stands using regression kriging. The study was carried out in 62 stands with clonal plantations of Eucalyptus sp. Data were collected at 24, 36, 48, 60, 72 and 84 months in 170 sampling units of 400 m². The variables diameter at 1.30 m above the ground (DBH), total height (Ht) were measured and, subsequently, the average height of the dominant trees (Hd) was obtained. The classification of productive capacity was carried out using the algebraic difference method, with the models: Schumacher, Chapman and Richards and Bailey and Clutter. The site index was interpolated by applying ordinary kriging and regression kriging. The results indicated that the site index showed spatial dependence in all adjustments. It is concluded that regression models for estimating the site index can be used in combination with regression kriging techniques. 6 sp 24 36 48 60 7 8 17 40 m² 130 1 30 1.3 DBH, DBH , (DBH) Ht (Ht subsequently Hd (Hd obtained method Schumacher Clutter adjustments techniques 2 3 4 13 1. (DBH

Resumo Introdução: O mecanismo de ação dos inibidores do co-transportador de sódio-glicose 2 (iSGLT2) consiste no aumento da glicosúria. Existe evidência da associação entre a sua toma e a ocorrência de infeções genitais. Porém, a associação com infeções do trato urinário (ITU) não está bem estabelecida. Pretende-se analisar a evidência atual sobre a associação entre iSGLT2 em doentes com diabetes mellitus tipo 2 e a ocorrência de ITU. Métodos: Pesquisadas normas de orientação clínica, meta-análises (MA), revisões sistemáticas e ensaios clínicos controlados e aleatorizados (ECCA) entre outubro de 2011 e outubro de 2021 na The National Institute for Health and Care Excellence, The Cochrane Library e PubMed. Utilizados os termos MeSH “urinary tract infection”, “sodium-glucose transporter 2 inhibitors” e “diabetes mellitus, type 2”. Para atribuição dos níveis de evidência (NE) foi utilizada a escala Strength of Recommendation Taxonomy, da American Academy of Family Physicians. Resultados: Dos 331 resultados identificados, 6 cumpriram os critérios de inclusão: 5 ECCA e 1 MA. Todos classificados com NE 2. A evidência da associação entre a toma de iSGLT2 e ITU foi apenas demonstrada, de forma estatisticamente significativa, na MA e relativamente à dapagliflozina na dosagem de 10 mg. Conclusão: Os estudos apresentam resultados heterogéneos, inconsistentes e de qualidade moderada. Os iSGLT2 têm afirmado o seu lugar no tratamento de múltiplas patologias pelo que impera a realização de estudos dirigidos à ocorrência de efeitos adversos como a frequência de ITU. Devem ainda compreender amostras de maior dimensão, diferentes moléculas e posologias, para a obtenção de evidência robusta.

Abstract Introduction: The mechanism of action of the sodium-glucose transporter 2 inhibitors (SGLT2i) is based on the increase of glycosuria. Current evidence shows an association between their intake and the occurrence of genital infections. However, the association with the occurrence of urinary tract infections (UTI) is not well established. We intend to analyze the evidence on the association between SGLT2i in patients with type 2 diabetes mellitus and the occurrence of UTI. Methods: The research comprised clinical guidelines, randomized controlled trials (RCT), meta-analysis (MA) and systematic reviews published in the National Institute for Health and Care Excellence, Cochrane Library and PubMed databases between October 2011 and October 2021. MeSH terms used: "urinary tract infection", "sodium-glucose transporter 2 inhibitors" and "diabetes mellitus, type 2". The Strength of Recommendation Taxonomy scale of the American Academy of Family Physicians was used for assigning evidence levels. Results: Of the 331 results, 6 met the inclusion criteria: 5 RCT and 1 MA. All were classified with level 2 of evidence. Only the MA showed a statistically significant association between the increase in UTI with the use of dapagliflozin 10 mg. Conclusion: The studies show heterogenous, inconsistent and moderate quality results. SGLT2i have a major role in the treatment of many different pathologies, which is why it is imperative to carry out studies targeted to analyze the occurrence of UTI. These should comprise larger study samples, with analysis of different molecules and dosages that could contribute to a higher level of evidence.

A equinococose/hidatidose é comum em sociedades onde predominam a agricultura e a criação de gado, sendo um problema de saúde pública. As várias opções terapêuticas dependem das caraterísticas do quisto, do doente e da eventual presença de contraindicações cirúrgicas. A colangiopancreatografia retrógrada endoscópica constitui uma válida ferramenta no diagnóstico e tratamento da doença hidática hepática complicada. A ecografia é um instrumento útil no diagnóstico, na terapêutica e seguimento. Os autores apresentam um caso de uma doente de 56 anos a quem foi diagnosticado um quisto hidático hepático nos segmentos IVa/VIII, descrevem as opções terapêuticas e o seguimento de 50 meses livres de doença.

Echinococcosis/hydatidosis is common in societies where agriculture and livestock are frequent, and represents a public health problem. The therapeutic management depends on the cyst's characteristics, the patient, and surgical contraindications. Endoscopic retrograde cholangiopancreatography is a valuable tool in the diagnosis and treatment of complicated hepatic hydatid disease. Ultrasonography is a useful diagnostic, therapeutic and follow-up tool. The authors report a case of a 56 years old patient who was diagnosed with a hepatic hydatid cyst in the IVa/VIII segments, describe the therapeutic options and 50 months of disease-free follow-up.

INTRODUÇÃO: A endometriose consiste na presença de tecido endometrial ectópico em mulheres na idade reprodutiva. Geralmente surge em órgãos e estruturas dentro da cavidade pélvica, sendo o tubo digestivo a localização extrapélvica mais frequente. CASO CLÍNICO: Mulher, 40 anos, com antecedentes de gravidez ectópica e salpingectomia bilateral que recorreu ao Serviço de Urgência por hematoquézias. Os exames endoscópicos permitiram identificar o intestino delgado como provável origem da hemorragia digestiva. Laparoscopia exploradora com identificação de endometriose do ovário com invasão do íleon. CONCLUSÃO: A hemorragia digestiva é uma forma de apresentação da endometriose pouco frequente. Os autores alertam para a importância de considerar esta entidade clínica no diagnóstico diferencial de hemorragia digestiva de origem obscura, especialmente em mulheres jovens.

INTRODUCTION: Endometriosis is the presence of ectopic endometrial tissue, and is diagnosed in childbearing women. It is more frequent in organs and structures within the pelvic cavity. Outside the pelvis, the digestive tract is the most common location. CLINICAL CASE: Woman, 40 years old, who was admitted to our urgency complaining of hematoquezias. She had history of ectopic pregnancy and bilateral salpingectomy. The endoscopic examination identified the small intestine as probable source of gastrointestinal bleeding. Exploratory laparoscopy allowed identification of ovarian endometriosis with invasion of the ileum. CONCLUSION: Gastrointestinal bleeding is an uncommon form of presentation of endometriosis. It is important to consider this clinical entity in the differential diagnosis of gastrointestinal bleeding of obscure origin, especially in young women.