RESUMO Introdução: Doenças pulmonares são comuns em pacientes com doença renal em estágio terminal (DRET), dificultando o diagnóstico diferencial com COVID-19. Este estudo descreve achados de tomografia computadorizada de tórax (TC) em pacientes com DRET em terapia renal substitutiva (TRS) hospitalizados com suspeita de COVID-19. Métodos: Indivíduos maiores de 18 anos com DRET, encaminhados ao pronto-socorro com suspeita de COVID-19 foram incluídos. Dados clínicos e epidemiológicos foram extraídos de registros eletrônicos de saúde. A TC foi classificada como típica, indeterminada, atípica, negativa. Comparamos achados tomográficos de pacientes com COVID-19 positivos e negativos. Resultados: Recrutamos 109 pacientes (62,3% COVID-19-positivos) entre março e dezembro de 2020, idade média de 60 ± 12,5 anos, 43% mulheres. A etiologia mais comum da DRET foi diabetes. Tempo médio em diálise foi 36 meses, intervalo interquartil = 12–84. A lesão pulmonar mais comum foi opacidades em vidro fosco. O padrão típico de TC foi mais comum em pacientes com COVID-19 (40 (61%) vs. 0 (0%) em pacientes sem COVID-19, p < 0,001). Sensibilidade 60,61% (40/66), especificidade 100% (40/40). Valores preditivos positivos e negativos foram 100% e 62,3%, respectivamente. Padrão atípico de TC foi mais frequente em pacientes COVID-19-negativos (9 (14%) vs. 24 (56%) em COVID-19-positivos, p < 0,001), enquanto padrão indeterminado foi semelhante em ambos os grupos (13 (20%) vs. 6 (14%), p = 0,606), e padrão negativo foi mais comum em pacientes COVID-19-negativos (4 (6%) vs. 12 (28%), p = 0,002). Conclusões: Em pacientes com DRET em TRS hospitalizados, um padrão atípico de TC de tórax não pode excluir adequadamente o diagnóstico de COVID-19. Introdução , (DRET) COVID19. COVID19 COVID 19. 19 (TC (TRS Métodos 1 prontosocorro pronto socorro COVID-1 incluídos saúde típica indeterminada atípica negativa Resultados 10 62,3% 623 62 3 (62,3 COVID19positivos COVIDpositivos COVID-19-positivos 2020 125 5 12, 43 mulheres diabetes meses 1284 84 12–84 fosco 40 61% 61 (61% vs 0% (0% COVID19, 19, 0,001. 0001 0,001 . 001 0,001) 6061 60,61 40/66, 4066 40/66 66 (40/66) 100 40/40. 4040 40/40 (40/40) respectivamente COVID19negativos COVIDnegativos 9 ( 14% 14 (14% 2 56% 56 (56% COVID19positivos, positivos, 0,001, 13 (1 20% 20 (20% 14%, 0,606, 0606 0,606 606 0,606) 4 6% (6% 28%, 28 28% (28%) 0,002. 0002 0,002 002 0,002) Conclusões (DRET COVID1 COVID- 62,3 (62, 202 128 8 12–8 (61 (0 000 0,00 00 60,6 406 40/6 (40/66 404 40/4 (40/40 (14 (56 (20 060 0,60 (6 (28% 62, (62 12– 0,0 60, 40/ (40/6 (40/4 (5 (2 06 0,6 (28 0, (40/

ABSTRACT Introduction: Lung diseases are common in patients with end stage kidney disease (ESKD), making differential diagnosis with COVID-19 a challenge. This study describes pulmonary chest tomography (CT) findings in hospitalized ESKD patients on renal replacement therapy (RRT) with clinical suspicion of COVID-19. Methods: ESKD individuals referred to emergency department older than 18 years with clinical suspicion of COVID-19 were recruited. Epidemiological baseline clinical information was extracted from electronic health records. Pulmonary CT was classified as typical, indeterminate, atypical or negative. We then compared the CT findings of positive and negative COVID-19 patients. Results: We recruited 109 patients (62.3% COVID-19-positive) between March and December 2020, mean age 60 ± 12.5 years, 43% female. The most common etiology of ESKD was diabetes. Median time on dialysis was 36 months, interquartile range = 12–84. The most common pulmonary lesion on CT was ground glass opacities. Typical CT pattern was more common in COVID-19 patients (40 (61%) vs 0 (0%) in non-COVID-19 patients, p < 0.001). Sensitivity was 60.61% (40/66) and specificity was 100% (40/40). Positive predictive value and negative predictive value were 100% and 62.3%, respectively. Atypical CT pattern was more frequent in COVID-19-negative patients (9 (14%) vs 24 (56%) in COVID-19-positive, p < 0.001), while the indeterminate pattern was similar in both groups (13 (20%) vs 6 (14%), p = 0.606), and negative pattern was more common in COVID-19-negative patients (4 (6%) vs 12 (28%), p = 0.002). Conclusions: In hospitalized ESKD patients on RRT, atypical chest CT pattern cannot adequately rule out the diagnosis of COVID-19. Introduction ESKD, , (ESKD) COVID19 COVID 19 COVID-1 challenge (CT RRT (RRT COVID19. 19. Methods 1 records typical Results 10 62.3% 623 62 3 (62.3 COVID19positive COVIDpositive COVID-19-positive 2020 125 5 12. 43 female diabetes months 1284 84 12–84 opacities 40 61% 61 (61% 0% (0% nonCOVID19 nonCOVID non non-COVID-1 0.001. 0001 0.001 . 001 0.001) 6061 60.61 40/66 4066 66 (40/66 100 40/40. 4040 40/40 (40/40) respectively COVID19negative COVIDnegative 9 ( 14% 14 (14% 2 56% 56 (56% COVID19positive, positive, 0.001, 13 (1 20% 20 (20% 14%, 0.606, 0606 0.606 606 0.606) 4 6% (6% 28%, 28 28% (28%) 0.002. 0002 0.002 002 0.002) Conclusions (ESKD COVID1 COVID- 62.3 (62. 202 128 8 12–8 (61 (0 nonCOVID1 non-COVID- 000 0.00 00 60.6 40/6 406 (40/6 404 40/4 (40/40 (14 (56 (20 060 0.60 (6 (28% 62. (62 12– non-COVID 0.0 60. 40/ (40/ (40/4 (5 (2 06 0.6 (28 0.

ABSTRACT Among weed control methods, chemical control using herbicides is one of the most widely employed due to its practicality and efficiency. However, there is still a lack of reliable information regarding the effectiveness of low-volume spraying and the droplet spectrum for contact herbicides, such as fomesafen. The objective was to determine the spray volume and droplet spectrum for applying the fomesafen herbicide and its efficacy in controlling hairy beggarticks (Bidens pilosa) and littlebell (Ipomoea triloba). The herbicide was applied using a CO2-pressurized knapsack sprayer with TT11002 spray tip spaced at 0.50 m, operating at pressures of 100 kPa (very coarse droplets) and 400 kPa (medium-sized droplets) with spray volumes of 35, 70, 140, and 280 L ha-1, obtained by varying the application speed. At the time of application, the percentage of covered area and droplet density (droplets cm-²) were evaluated on water-sensitive paper labels using the DropScope® program. The best control results for hairy beggarticks were achieved when the application was performed with very coarse droplets at a pressure of 100 kPa, with a spray volume between 65 and 280 L ha-1, droplet density exceeding 60 droplets cm-2, and coverage greater than 10%. Fomesafen does not provide effective control of littlebell. methods efficiency However lowvolume low Bidens pilosa Ipomoea triloba. triloba . triloba) CO2pressurized COpressurized CO2 pressurized CO TT TT1100 050 0 50 0.5 m 10 40 mediumsized medium sized 35 70 140 28 ha1, ha1 ha 1, 1 ha-1 speed cm² cm ² cm-² watersensitive water sensitive DropScope program 6 cm2, cm2 2, 2 cm-2 10% TT110 05 5 0. 4 3 7 14 ha- cm- TT11 TT1

RESUMO Dentre os métodos de controle de plantas daninhas, o químico, por meio de herbicidas, é um dos mais utilizados devido à sua praticidade e eficiência. No entanto, ainda faltam informações confiáveis sobre a eficácia de aplicações em baixo volume e o espectro de gotas a ser utilizado para herbicidas de contato, como o fomesafen. O objetivo deste trabalho foi determinar o volume de calda e espectro de gotas para aplicação do herbicida fomesafen, bem como a eficácia no controle de picão-preto (Bidens pilosa) e corda-de-viola (Ipomoea triloba). O herbicida foi aplicado utilizando pulverizador pressurizado por CO2, com pontas TT11002 espaçadas de 0,50 m, operando nas pressões de 100 kPa (gotas muito grossas) e 400 kPa (gotas médias) nos volumes de calda de 35, 70, 140 e 280 L ha-1, obtidos por meio da variação na velocidade de aplicação. No momento da aplicação foram avaliados a porcentagem de área coberta e a densidade de gotas (gotas cm-²) em etiquetas de papel hidrossensível, utilizando o programa DropScope®. Melhores índices de controle do picão-preto são obtidos quando a aplicação foi realizada com gotas muito grossas, na pressão de 100 kPa, com volume de calda entre 65 e 280 L ha-1, densidade de gotas superior a 60 gotas cm-2 e cobertura maior que 10%. O fomesafen não controla a corda-de-viola. daninhas químico eficiência entanto contato picãopreto picão preto Bidens pilosa cordadeviola corda viola Ipomoea triloba. triloba . triloba) CO2 CO TT TT1100 050 0 50 0,5 m 10 grossas 40 médias 35 70 14 28 ha1, ha1 ha 1, 1 ha-1 cm² cm ² cm-² hidrossensível DropScope DropScope® 6 cm2 2 cm- 10% cordadeviola. viola. TT110 05 5 0, 4 3 7 ha- TT11 TT1

ABSTRACT Background Robotic-assisted radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD) is associated with significant morbidity and mortality. We present an alternative technique that preserves the complete mesenteric vascularization during the isolation of the intestinal segment used in ICUD, including distal vessels. This approach aims to minimize the risk of ischemia in both the ileal anastomosis and the isolated loop at the diversion site. Methods This cohort study included 31 patients, both male and female, who underwent RARC with ICUD from February 2018 to November 2023, performed by a single surgeon. Intraoperative and postoperative complications data were retrieved for analysis, employing our proposed mesentery-sparing technique in all cases. The primary endpoint was the incidence of intraoperative and postoperative complications directly attributable to the mesentery-sparing approach in ICUD. Secondary endpoints included other postoperative variables not directly related to mesentery preservation, such as the incidence of postoperative ileus requiring parenteral nutrition and the duration of hospitalization. Results None of the patients experienced intraoperative or postoperative complications directly related to mesentery-sparing, such as intestinal fistulae or internal hernias. The median duration of hospitalization was 6 days, and postoperative ileus necessitating total parenteral nutrition occurred in 19% of the patients. Minor complications (Clavien–Dindo grades I-II) accounted for 27.6% of the cases and major complications (grades III-V) accounted for 20.6%. Conclusion The mesentery-sparing technique outlined herein offers an alternative method for preserving the vascularization of intestinal segments and reducing the risk of intestinal complications in ICUD during RARC. Roboticassisted Robotic assisted (RARC (ICUD mortality vessels site 3 female 201 2023 surgeon analysis mesenterysparing sparing preservation mesenterysparing, sparing, hernias days 19 Clavien–Dindo ClavienDindo Clavien Dindo III I II I-II 276 27 27.6 IIIV V III-V 206 20 20.6% 202 1 2 27. 20.6 20.

Resumo O objetivo do artigo é avaliar a prevalência de adesão ao tratamento anti-hipertensivo na população brasileira, com base nos estudos revisados por pares, que utilizaram instrumentos elaborados e/ou adaptados exclusivamente para este fim. Revisão sistemática com meta-análise, baseada nas recomendações do Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A busca foi realizada nas bases BDENF, SciELO, Cuiden, PsycINFOe, CINAHL, Embase, LILACS, MEDLINE, e nos buscadores acadêmicos AgeLine, Google Scholar e ScienceDirect. O protocolo foi registrado no PROSPERO (CRD42021292689). Modelos de efeitos aleatórios foram usados para meta-análise das prevalências obtidas dos estudos individuais. Incluíram-se 104 estudos na meta-análise sobre tratamento anti-hipertensivo na população brasileira, totalizando 38.299 pacientes. O instrumento mais utilizado foi o teste de Morisky-Green de quatro itens (49,5%). A prevalência de adesão estimada pela foi de 44,4% (IC95%: 39,12%-49,94%, I2 = 91,17, p < 0,001), apresentando alta heterogeneidade. A prevalência de adesão ao tratamento anti-hipertensivo encontrada nos estudos nacionais foi insatisfatória, demonstrando que essa problemática continua sendo um grande desafio. antihipertensivo anti hipertensivo brasileira pares eou ou fim metaanálise, metaanálise meta análise, análise MetaAnalyses Meta Analyses PRISMA. PRISMA . (PRISMA) BDENF SciELO Cuiden PsycINFOe CINAHL Embase LILACS MEDLINE AgeLine ScienceDirect CRD42021292689. CRD42021292689 CRD (CRD42021292689) individuais Incluíramse Incluíram se 10 38299 38 299 38.29 pacientes MoriskyGreen Morisky Green 49,5%. 495 49,5% 49 5 (49,5%) 444 44 4 44,4 IC95% IC95 IC (IC95% 39,12%49,94%, 39124994 39,12% 49,94%, 39 12 94 39,12%-49,94% I 9117 91 17 91,17 0,001, 0001 0,001 , 0 001 0,001) heterogeneidade insatisfatória desafio (PRISMA CRD4202129268 (CRD42021292689 1 3829 3 29 38.2 49,5 (49,5% 44, IC9 (IC95 39,12%49,94% 3912499 3912 39,12 4994 49,94% 9 39,12%-49,94 911 91,1 000 0,00 00 CRD420212926 (CRD4202129268 382 2 38. 49, (49,5 (IC9 39,12%49,94 391249 391 39,1 499 49,94 39,12%-49,9 91, 0,0 CRD42021292 (CRD420212926 (49, (IC 39,12%49,9 39124 39, 49,9 39,12%-49, 0, CRD4202129 (CRD42021292 (49 39,12%49, 39,12%-49 CRD420212 (CRD4202129 (4 39,12%49 39,12%-4 CRD42021 (CRD420212 ( 39,12%4 39,12%- CRD4202 (CRD42021 CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

Abstract This article aims to evaluate the adherence to antihypertensive treatment prevalence in the Brazilian population based on peer-reviewed studies which used instruments exclusively designed and/or adapted for this purpose. A systematic review with meta-analysis based on the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The search was carried out in the BDENF, SciELO, Cuiden, PsycINFOe, CINAHL, Embase, LILACS, and MEDLINE databases, as well as the AgeLine, Google Scholar and ScienceDirect academic search engines. The protocol was registered with PROSPERO (CRD42021292689). Random effects models were used for a meta-analysis of the prevalence obtained from individual studies. A total of 104 studies were included in the meta-analysis on antihypertensive treatment in the Brazilian population, totaling 38,299 patients. The most used instrument was the four-item Morisky-Green Test (49.5%). The adherence prevalence estimated by the meta-analysis was 44.4% (95%CI: 39.12%-49.94%, I2 = 91.17, p < 0.001), showing high heterogeneity. The adherence to antihypertensive treatment prevalence found in national studies was unsatisfactory, demonstrating that this problem continues to be a major challenge. peerreviewed peer reviewed andor or purpose metaanalysis meta analysis MetaAnalyses Meta Analyses PRISMA. PRISMA . (PRISMA) BDENF SciELO Cuiden PsycINFOe CINAHL Embase LILACS databases AgeLine engines CRD42021292689. CRD42021292689 CRD (CRD42021292689) 10 38299 38 299 38,29 patients fouritem four item MoriskyGreen Morisky Green 49.5%. 495 49.5% 49 5 (49.5%) 444 44 4 44.4 95%CI 95CI CI 95 (95%CI 39.12%49.94%, 39124994 39.12% 49.94%, 39 12 94 39.12%-49.94% I 9117 91 17 91.17 0.001, 0001 0.001 , 0 001 0.001) heterogeneity unsatisfactory challenge (PRISMA CRD4202129268 (CRD42021292689 1 3829 3 29 38,2 49.5 (49.5% 44. 9 39.12%49.94% 3912499 3912 39.12 4994 49.94% 39.12%-49.94 911 91.1 000 0.00 00 CRD420212926 (CRD4202129268 382 2 38, 49. (49.5 39.12%49.94 391249 391 39.1 499 49.94 39.12%-49.9 91. 0.0 CRD42021292 (CRD420212926 (49. 39.12%49.9 39124 39. 49.9 39.12%-49. 0. CRD4202129 (CRD42021292 (49 39.12%49. 39.12%-49 CRD420212 (CRD4202129 (4 39.12%49 39.12%-4 CRD42021 (CRD420212 ( 39.12%4 39.12%- CRD4202 (CRD42021 CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

Abstract Objectives: The aim was to estimate the pubertal growth height of children and adolescents living in a high-altitude region of Peru using the Preece-Baines model 1 (1 PB). Methods: A cross-sectional study was conducted in schoolchildren from the department of Puno (Peru) between 3841 and 3874 masl. The age range was between 4 and 17 years. Standing height was evaluated. 1 PB was used to infer the mathematical and biological parameters of stature. Results: Mathematical parameters estimated by the 1 PB model reflected small residual standard error (RSE) values in both sexes (0.25 in boys and 0.27 in girls). In boys, the age at which peak velocity was reached (APHV) was estimated at 13.21 ± 0.33years. While in girls it was 9.96 ± 0.26years (p < 0.05). In general, girls reached APHV (y) 3.25 years earlier than boys. On the other hand, the growth velocity of maximum height [APHV (cm/y)] of boys was higher (6.33 ± 6.06 cm/y) relative to girls (6.06 ± 0.32 cm/y). Estimated final adult height (EFAH) in boys was reached at 166.020 ± 0.99 cm and height at maximum growth velocity (HPHV) was 153.07 ± 0.67 cm, while in girls they were significantly lower (EFAH; 153.74 ± 0.44 cm and HPHV: 139.73 ± 0.84 cm). Conclusions: This study showed that girls living in Puno at a high altitude in Peru reached APHV 3 years earlier than boys and at the same time reflected slower PHV. These results suggest that pubertal growth at high altitudes is slower in both sexes and especially in girls. Thus, modeling physical growth may be an important step in understanding the onset of puberty at different latitudes. Objectives highaltitude PreeceBaines Preece Baines ( PB. . PB) Methods crosssectional cross sectional (Peru 384 387 masl evaluated stature Results RSE (RSE 0.25 025 0 25 (0.2 027 27 0.2 girls) (APHV 1321 13 21 13.2 033years 33years 0.33years 996 9 96 9.9 026years 26years p 0.05. 005 0.05 05 0.05) general y (y 325 3.2 hand cm/y cmy (cm/y) 6.33 633 6 33 (6.3 606 06 6.0 (6.0 032 32 0.3 cm/y. EFAH (EFAH 166020 166 020 166.02 099 99 0.9 HPHV (HPHV 15307 153 07 153.0 067 67 0.6 15374 74 153.7 044 44 0.4 13973 139 73 139.7 084 84 0.8 cm. cm) Conclusions PHV Thus latitudes 38 02 2 (0. 0. 132 13. 9. 00 0.0 3. (cm/y 6.3 63 (6. 60 6. 03 16602 16 166.0 09 1530 15 153. 1537 7 04 1397 139. 08 8 (0 (6 1660 166.

Abstract This work presents the first results obtained from developing an experimental program that aims to generate a local frame of reference for the fatty acid profiles of the main resources available in the lower basin of the Colorado river (Buenos Aires district). In this case, the purpose was to identify the fatty acid composition of fish resources and evaluate the main transformations they underwent during cooking. Replicas of archaeological vessels were made, marine fish of different species (sea catfish, whitemouth croaker, narrownose smooth-hound, conger eel, and whiting) were boiled, and the fatty acids of the raw and cooked meat, the cooking liquid, and those of the contents on the internal walls of the vessels were measured. The results obtained showed that fatty acids could be detected in all samples. However, if those identified in the raw meat of each species are compared with those detected after boiling, it is observed that the cooking event generated the loss and/or degradation of some fatty acids, mainly unsaturated ones. Fatty acids (e.g., stearic, palmitic, and oleic acid) present in most food resources (e.g., herbivores and vegetables) were preserved in the vessels. However, fatty acids detected in the vessels such as the polyunsaturated belonging to the C20 group of sea catfish and whitemouth croaker, the eicosenoic acid of sea catfish, and the monounsaturated of the C22 group identified for the conger eel could be considered diagnostic fatty acids of marine fish.

Resumen En este trabajo se presentan los primeros resultados obtenidos del desarrollo de un programa experimental que tiene como objetivo generar un marco de referencia local de los perfiles de ácidos grasos de los principales recursos disponibles en el curso inferior del río Colorado (Pcia. de Buenos Aires). En este caso, el propósito fue conocer la composición de ácidos grasos de recursos ictícolas y evaluar las principales transformaciones que estos sufren durante la cocción. Para ello, se confeccionaron réplicas de vasijas arqueológicas, se hirvieron peces marinos de distintas especies (bagre de mar, corvina rubia, gatuzo, congrio y pescadilla) y se analizaron los ácidos grasos de la carne cruda y cocida, del líquido de cocción y de los contenidos en las paredes internas de las vasijas. Los resultados obtenidos evidenciaron que en todas las muestras de peces se pudieron detectar ácidos grasos. Sin embargo, si se comparan los identificados en la carne cruda de cada especie con los detectados con posterioridad al hervido, se observa que el evento de cocción generó la pérdida y/o degradación de algunos de ellos, principalmente de los ácidos insaturados. En las vasijas se preservaron los ácidos grasos (e.g., ácido esteárico, palmítico y oleico) que comúnmente están presentes en la mayoría de los recursos alimenticios (e.g., herbívoros, vegetales). No obstante, los ácidos grasos detectados en las vasijas como los poliinsaturados pertenecientes al grupo C20 de bagre de mar y corvina rubia, el ácido eicosenoico de bagre de mar y el monoinsaturado del grupo C22 identificado para el congrio podrían ser considerados ácidos grasos diagnósticos de peces marinos.

Abstract The human immunodeficiency virus (HIV) is one of the sexually transmitted infections with the greatest impact on the patient's life. Early diagnosis is essential to promptly initiate antiretroviral therapy and avoid the disease’s progression. We present the case of a 60-year-old woman with a three-month history of epigastric pain, ageusia and weight loss of 9%. She performed blood tests, upper and lower digestive endoscopy, and chest X-ray, which revealed a large hiatal hernia and mild lymphopenia. A month later, she developed dyspnea, temporospatial confusion, and a change in speech and went to the emergency department where she was diagnosed with HIV Infection. During hospitalization, further tests revealed a Pneumocystis jirovecci infection and the presence of primary lymphoma of the central nervous system, both acquired immunodeficiency syndrome (AIDS)-defining diseases. Wi this case we aim to alert for the importance of HIV diagnosis in patients with constitutional symptoms and its screening not only in at-high-risk populations but also, at least once a lifetime, in adults aged between 18 and 64 without risk factors.

Resumo O vírus da imunodeficiência humana (VIH) constitui uma das infeções sexualmente transmissíveis com maior impacto na vida do doente, sendo fundamental o diagnóstico precoce de forma a iniciar terapêutica antirretroviral atempadamente e evitar a evolução da doença. Apresentamos o caso de uma mulher de 60 anos com quadro de epigastralgia, ageusia e perda ponderal de 9% com 3 meses de evolução. Foi solicitado estudo analítico, endoscopia digestiva alta e baixa e radiografia do tórax, que revelaram hérnia do hiato volumosa e linfopenia ligeira. Um mês depois desenvolveu dispneia, confusão temporoespacial e alteração da fala, tendo recorrido ao serviço de urgência onde foi diagnosticada infeção por VIH. Durante o internamento objetivou-se infeção por Pneumocystis jirovecci e diagnóstico de linfoma primário do sistema nervoso central, ambas doenças definidoras da síndrome da imunodeficiência adquirida (SIDA). Com este caso pretendemos alertar para a exclusão do diagnóstico de VIH em doentes com sintomas constitucionais e para o seu rastreio não só em populações de risco como também, pelo menos uma vez durante a vida, em adultos dos 18 aos 64 anos sem fatores de risco.

Abstract Introduction: Eating disorders (ED) are a group of diseases with high morbidity and a significant impact on the lives of children and adolescents. These are biopsychosocial entities, involving individual, family and sociocultural factors. It is known that ED are highly comorbid with other psychiatric disorders. Organic complications are common. Our objective was to characterization of hospitalized patients in the Hospital Dona Estefânia’s Child and Adolescent Psychiatry Inpatient Unit during the year of 2022 with the main diagnosis of an ED. Description of patients’ characteristics from a familiar, social and medical point of view, as well as hospitalizations and follow-up. Methods: Retrospective and descriptive study based on the consultation of clinical records of the patients admitted to the Inpatient Child and Adolescent Psychiatry Unit from January to December 2022 with the diagnosis of an ED. Subsequently, a descriptive analysis and data processing were carried out using the SPSS software. Results: From a total of 48 patients, the mean age was 14 years and 4 months, the majority (95.8%, n=46) being female. Most cases (77.1%, n=37) corresponded to anorexia nervosa restricting type, 20.8% (n=10) corresponded to anorexia nervosa binge-eating/purgative type and one case referred to an avoidant/restrictive food intake disorder. Depressive disorders were the most frequent comorbid diagnosis (25%, n=12). Conclusion: Treatment of ED should include a multidisciplinary approach. In the future it will be crucial to reflect on the possible causes that lead to rehospitalization.

Resumo Introdução: As perturbações do comportamento alimentar (PCA) são patologias com alta morbilidade e significativo impacto na vida de crianças e adolescentes. Trata-se de doenças biopsicossociais, envolvendo fatores de natureza individual, familiar e sociocultural. Apresentam elevada comorbilidade com outras perturbações psiquiátricas. As complicações orgânicas são comuns. O nosso objetivo foi caracterização dos doentes internados com diagnóstico principal de Perturbação do Comportamento Alimentar na Unidade de Internamento de Pedopsiquiatria do HDE durante o ano de 2022. Descrição das características dos doentes do ponto de vista familiar, social e médico e dos respetivos internamentos e seguimentos. Métodos: Estudo retrospetivo, descritivo, a partir da consulta do processo clínico dos doentes internados na Unidade de Internamento de Pedopsiquiatria do HDE com o diagnóstico de PCA de janeiro a dezembro de 2022 (inclusive). Posteriormente foi realizada uma análise descritiva dos dados e tratamento com recurso ao programa SPSS. Resultados: De um total de 48 doentes, a média de idades foi de 14 anos e 4 meses, sendo a maioria (95,8%, n=46) do sexo feminino. A maioria (77,1%, n=37) correspondia a uma anorexia nervosa tipo restritivo, 20,8% (n=10) a uma anorexia tipo ingestão compulsiva/purgativo e um caso de perturbação de ingestão alimentar evitante/restritiva. As perturbações depressivas foram a comorbilidade mais frequente (25%, n=12). Conclusão: O tratamento das PCA deve ser feito a partir de uma abordagem multidisciplinar. Será importante, no futuro, uma reflexão sobre os principais motivos que conduzem à necessidade de reinternamento.

A 45-year-old female presented with unprovoked recurrent venous thromboembolism (VTE), in unusual sites, and pancytopenia, posing a complex diagnostic challenge. Work-up for inherited thrombophilia, antiphospholipid syndrome (APLS) and paroxysmal nocturnal haemoglobinuria were unremarkable. Investigations revealed autoimmune thyroid disease, and a mixed iron/vitamin B12 deficiency due to pernicious anaemia and resultant atrophic gastritis. Hyperhomocysteinaemia due to vitamin B12 deficiency was identified as a potential contributor to her recurrent VTE. This case highlights the unusual initial presentation of autoimmune polyendocrinopathy syndrome type 3B (APS-3B) with recurrent thromboembolism, and emphasises the importance of considering hyperhomocysteinaemia in unprovoked and atypical VTE cases.

ABSTRACT: Rhipicephalus (Boophilus) microplus is a hard tick endemic in livestock-growing regions and causes economic losses in the largest beef-producing countries, including Brazil, Mexico, Argentina, Australia and Uruguay. The use of chemical acaricides is still the main strategy to control R. microplusinfestations. Nevertheless, immunological control of R. microplus with an anti-tick vaccine is a suitable alternative and has manifold advantages because it can avoid drug-resistance and the presence of acaricide residues in milk, beef and in the environment. Indeed, vaccines based on the Bm86 antigen have had relative commercial and technical success to control R. microplus in some regions. Although, the efficacy of such vaccines varies among tick populations and is insufficient to provide an acceptable level of protection. Therefore, the need to search for better antigens is impelling. This review focused on the restrictions imposed on the use of acaricides in Brazil and in the European Union, as well as on the impacts of Bm86-based vaccines on R. microplus control. The efficacy of experimental anti-tick vaccines (based on subolesin, glutathione S-transferase, ferritin 2; voltage-dependent anion channel; aquaporin, 60 S acidic ribosomal protein, metalloprotease and trypsin) that can elicit an immune response against the physiological functions of various ticks is discussed. ABSTRACT Boophilus (Boophilus livestockgrowing livestock growing beefproducing producing countries Mexico Argentina Uruguay R microplusinfestations Nevertheless antitick anti drugresistance drug resistance milk environment Indeed Bm Bm8 Although protection Therefore impelling Union Bm86based Bmbased subolesin Stransferase, Stransferase transferase, transferase S-transferase 2 voltagedependent voltage dependent channel aquaporin 6 protein trypsin discussed

RESUMO: O Rhipicephalus (Boophilus) microplus é um carrapato duro que é endêmico de regiões de pecuária e causa perdas econômicas nos maiores países produtores de carne bovina, incluindo Brasil, México, Argentina, Austrália e Uruguai. O uso de acaricidas ainda é a principal estratégia para controlar infestações por R. microplus. No entanto, o controle imunológico do R. microplus com uma vacina contra carrapatos é uma alternativa adequada e possui diversas vantagens, por evitar a seleção de populações de carrapato resistentes a drogas, evitar a presença de resíduos de acaricidas no leite, na carne e no ambiente. As vacinas baseadas no antígeno Bm86 tiveram relativo sucesso comercial e técnico no controle do R. microplus em diversas regiões. No entanto, a eficácia dessas vacinas varia entre as populações de carrapatos e é insuficiente para fornecer um nível aceitável de proteção. Portanto, há uma necessidade de procurar novos antígenos. Esta revisão foca nas restrições impostas ao uso de acaricidas no Brasil e na União Europeia, bem como nos impactos das vacinas baseadas em Bm86 no controle do R. microplus. Também é discutida a eficácia de vacinas anti-carrapatos experimentais (baseadas em subolesina, glutationa S-transferase, ferritina 2; canal aniônico dependente de voltagem; aquaporina, proteína ribossômica ácida 60S, metaloprotease, tripsina) que podem elicitar uma resposta imune contra as funções fisiológicas de vários carrapatos. RESUMO Boophilus (Boophilus bovina México Argentina Uruguai R entanto vantagens drogas leite ambiente Bm Bm8 proteção Portanto antígenos Europeia anticarrapatos anti subolesina Stransferase, Stransferase S transferase, transferase S-transferase 2 voltagem aquaporina 60S metaloprotease tripsina

ABSTRACT Objective: This study aimed to verify the association between childhood anthropometric indicators and areal bone mineral density (aBMD) in adulthood. Methods: Repeated measures of 137 subjects (68 females) were obtained in childhood (9.2±1.5 years of age) and adulthood (22.3±1.7 years of age). aBMD (g/cm2) was assessed for whole body, lumbar spine, upper and lower limbs, and femoral neck in adulthood using dual-energy X-ray absorptiometry. Anthropometric measurements of body weight (BW), height, triceps and subscapular skinfolds were obtained in childhood. The anthropometric indicators used were BW, body mass index (BMI), and sum of skinfolds (ΣSF). Simple linear regression was used to assess the association between childhood anthropometric indicators and aBMD in adulthood, controlled by chronological age and stratified by sex, with 5% statistical significance. Results: In females, multiple associations were observed between anthropometric indicators and aBMD, with higher coefficients for BMI (β=0.020; R2=0.20; p<0.01 for right femoral neck to β=0.008; R2=0.16; p<0.01 for upper limbs), followed by BW (β=0.003; R2=0.21; p<0.01 for upper limbs to β=0.008; R2=0.20; p<0.01 for right femoral neck) and ΣSF (β=0.001; R2=0.06; p<0.01 for upper limbs to β=0.005; R2=0.12; p<0.01 for right femoral neck). In males, associations were observed only for the lumbar spine region (β=0.016; R2=0.09 for BMI to β=0.004; R2=0.06; p<0.01 for ΣSF). Conclusions: Anthropometric indicators of childhood proved to be sensitive predictors of aBMD in adulthood, especially in females. BMI indicated a greater association with aBMD in both sexes. Objective (aBMD Methods 13 68 (6 females 9.2±1.5 9215 9 2 1 5 (9.2±1. 22.3±1.7 22317 22 3 7 (22.3±1. age. . g/cm2 gcm2 gcm g cm2 cm (g/cm2 dualenergy dual energy Xray X ray absorptiometry , (BW) height BMI, (BMI) ΣSF. (ΣSF) sex significance Results β=0.020 β0020 β 0 020 (β=0.020 R2=0.20 R2020 R R2 20 p001 p 01 p<0.0 β=0.008 β0008 008 R2=0.16 R2016 16 limbs) β=0.003 β0003 003 (β=0.003 R2=0.21 R2021 21 β=0.001 β0001 001 (β=0.001 R2=0.06 R2006 06 β=0.005 β0005 005 R2=0.12 R2012 12 neck. males β=0.016 β0016 016 (β=0.016 R2009 09 R2=0.0 β=0.004 β0004 004 ΣSF) Conclusions sexes 6 ( 9.2±1. 921 (9.2±1 22.3±1. 2231 (22.3±1 g/cm (g/cm (BW (BMI (ΣSF β=0.02 β002 02 (β=0.02 R2=0.2 R202 p00 p<0. β=0.00 β000 00 R2=0.1 R201 (β=0.00 R200 β=0.01 β001 (β=0.01 R2=0. 9.2±1 92 (9.2± 22.3±1 223 (22.3± β=0.0 β00 (β=0.0 R20 p0 p<0 R2=0 9.2± (9.2 22.3± (22.3 β=0. β0 (β=0. p< R2= 9.2 (9. 22.3 (22. β=0 (β=0 9. (9 22. (22 β= (β= (2 (β

RESUMO Objetivo: O objetivo do estudo foi verificar a associação entre os indicadores antropométricos da infância com a área da densidade mineral óssea (aDMO) na idade adulta. Métodos: Medidas repetidas de 137 sujeitos (68 do sexo feminino) foram obtidos na infância (9,2±1,5 anos de idade) e idade adulta (22,3±1,7 anos de idade). A aDMO (g/cm2) foi avaliada para todo o corpo, coluna lombar, membros superiores e inferiores e colo do fêmur na idade adulta usando a absorciometria radiológica de dupla energia (DXA). Medidas antropométricas de peso corporal, estatura e dobras cutâneas das regiões tricipital e subescapular foram obtidas na infância. Os indicadores antropométricos utilizados para as análises foram o peso corporal (PC), o índice de massa corporal (IMC) e o somatório de dobras cutâneas (ΣDC). Regressão linear simples controlada pela idade e estratificada por sexo foi empregada para avaliar a associação entre os indicadores antropométricos do período da infância na aDMO na idade adulta, com significância estatística de 5%. Resultados: No sexo feminino, múltiplas associações foram observadas entre os indicadores antropométricos e a aDMO, com maiores coeficientes para IMC (β=0,020; R2=0,20; p<0.01 para colo do fêmur direito a β=0,008; R2=0,16; p<0,01 para membros superiores), seguido da PC (β=0,003; r2=0,21; p<0,01 para membros superiores a β=0,008; r2=0,20; p<0,01 para colo do fêmur direito) e ΣDC (β=0,001; R2=0,06; p<0,01 para membros superiores a β=0,005; R2=0,12; p<0,01 para colo do fêmur direito). No sexo masculino, associações ocorreram apenas na região da coluna (β=0,016; R2=0,09 para IMC a β=0,004; R2=0,06; p<0,01 para ΣDC). Conclusões: Indicadores antropométricos da infância mostraram ser sensíveis preditores da aDMO na idade adulta, especialmente no sexo feminino. O IMC indicou maior associação com a aDMO em ambos os sexos. Objetivo (aDMO Métodos 13 68 (6 feminino 9,2±1,5 9215 9 2 1 5 (9,2±1, 22,3±1,7 22317 22 3 7 (22,3±1, idade. . g/cm2 gcm2 gcm g cm2 cm (g/cm2 corpo lombar DXA. DXA (DXA) PC, , (PC) (IMC ΣDC. (ΣDC) 5% Resultados β=0,020 β0020 β 0 020 (β=0,020 R2=0,20 R2020 R R2 20 p001 p 01 p<0.0 β=0,008 β0008 008 R2=0,16 R2016 16 p<0,0 superiores, superiores) β=0,003 β0003 003 (β=0,003 r2=0,21 r2021 r r2 21 r2=0,20 r2020 β=0,001 β0001 001 (β=0,001 R2=0,06 R2006 06 β=0,005 β0005 005 R2=0,12 R2012 12 direito. masculino β=0,016 β0016 016 (β=0,016 R2009 09 R2=0,0 β=0,004 β0004 004 ΣDC) Conclusões sexos 6 ( 9,2±1, 921 (9,2±1 22,3±1, 2231 (22,3±1 g/cm (g/cm (DXA (PC (ΣDC β=0,02 β002 02 (β=0,02 R2=0,2 R202 p00 p<0. β=0,00 β000 00 R2=0,1 R201 p<0, (β=0,00 r2=0,2 r202 R200 β=0,01 β001 (β=0,01 R2=0, 9,2±1 92 (9,2± 22,3±1 223 (22,3± β=0,0 β00 (β=0,0 R20 p0 p<0 r2=0, r20 R2=0 9,2± (9,2 22,3± (22,3 β=0, β0 (β=0, p< r2=0 R2= 9,2 (9, 22,3 (22, β=0 (β=0 r2= 9, (9 22, (22 β= (β= (2 (β

Abstract Parasitic resistance imposes alternative control methods, like nematophagous fungi. In this study, two experiments were conducted supplying Duddingtonia flagrans aiming to evaluate the biological control of parasites in sheep. In the first, 24 sheep naturally infected by gastrointestinal nematodes were allocated, in randomized blocks, following the treatments: control or treated group, 0.5g/animal product containing D. flagrans, chlamydospores. Weight, body score, Famacha©, egg count per gram of feces (EPG), and larval percentage were evaluated. In the second experiment, D. flagrans (0.25 and 0.5g product) was infested with manure, plus or not protein concentrate, in a completely randomized design. In both experiments the dose was intentionally lower than recommended. Recovery and larval identification were performed. The SAS analyzed the variables by the MIXED procedure, repeated measures in time. Weight, body score, hematocrit, and Famacha© did not show differences between treatments (p>0.05); however, EPG (p<0.001) and the percentage of larvae identified in coproculture were different. In the second experiment, the inclusion of the fungus did not influence the recovery of larvae (p>0.05). In both experiments, colonization and advancement of the fungus were visualized. Under the experimental conditions, the fungus D. flagrans was not effective in the biological control of parasitic infection in sheep. methods fungi study first 2 allocated blocks group 05ganimal ganimal 0 5g animal g D chlamydospores Weight score Famacha EPG, , (EPG) evaluated experiment 0.25 025 25 (0.2 05g manure concentrate design recommended performed procedure time hematocrit p>0.05 p005 p 05 (p>0.05) however p<0.001 p0001 001 (p<0.001 different p>0.05. . visualized conditions (EPG 0.2 02 (0. p>0.0 p00 (p>0.05 p<0.00 p000 00 (p<0.00 0. (0 p>0. p0 (p>0.0 p<0.0 (p<0.0 ( p>0 (p>0. p<0. (p<0. p> (p>0 p<0 (p<0 (p> p< (p< (p