Resumen Introducción: El estado de alarma decretado por la pandemia del virus SARS COV-2 del 14 de marzo hasta el 21 de junio, ha supuesto un desafío para el área de pacientes externos de los Servicios de Farmacia. Nos centramos en los pacientes con hemofilia que se administran factores de la coagulación de forma crónica para prevenir hemorragias. Objetivos: Analizar durante este periodo el porcentaje de pacientes que han recogido su medicación, han mantenido la adherencia al tratamiento y las barreras encontradas para ello. Cuantificar el número y gravedad de episodios hemorrágicos (EH) sufridos y su relación con la pandemia. Analizar la prevalencia y gravedad de COVID en hemofílicos. Métodos: Uno objetivo, utilizando los registros del hospital y otro subjetivo, mediante encuesta oral durante la consulta de atención farmacéutica presencial o telemática. Resultados: El 80% de los pacientes retiraron medicación durante el periodo de estudio, un 30% en domicilio. El último mes las dispensaciones a domicilio se acompañaron de consulta telemática. Un 24% de pacientes disminuyó su adherencia respecto al 2019. Las principales causas fueron dificultad para acudir al hospital, y percepción de no necesitar tratamiento ante la inactividad. No se registraron más EH o ingresos por causas imputables a la pandemia. No hubo ningún enfermo COVID-19 grave y la incidencia de pacientes con síntomas leves fue similar a la población general. Conclusión: La mayoría de los pacientes con hemofilia pudieron acceder a su medicación. La adherencia se redujo. Los EH no aumentaron por causas atribuibles a la pandemia. La incidencia de COVID-19 fue similar a la población.

Summary Introduction: The state of alarm decreed by the SARS COV-2 virus pandemic from March 14th to June 21st, has meant a challenge for the outpatient area of the pharmacy services. We focus on hemophilia patients who are chronically administered clotting factors to prevent bleeding. Objectives: To analyse during this period the percentage of patients who have collected their medication, maintained adherence to treatment and the barriers encountered in doing so. To quantify the number and severity of haemorrhagic episodes (HD) suffered and their relationship with the pandemic. Analyse the prevalence and severity of COVID in haemophiliacs. Methods: One objective, using hospital records, and one subjective, using an oral survey during the face-to-face or telematic pharmaceutical care consultation. Results: 80% of patients withdrew medication during the study period, 30% at home. In the last month, home deliveries were accompanied by telematic consultation. 24% of patients decreased their adherence with respect to 2019. The main causes were difficulty in going to hospital, and perception of not needing treatment in the face of inactivity. There were no more HD or admissions for reasons attributable to the pandemic. There were no serious COVID-19 patients and the incidence of patients with mild symptoms was similar to the general population. Conclusion: Most haemophilia patients were able to access their medication. Adherence was reduced. HD did not increase due to causes attributable to the pandemic. The incidence of COVID-19 was similar to the population.

ABSTRACT Introduction: Mapping a cochlear implant allows for adjusting ideal electrical stimulation limits. It is an individualized process and detecting the most comfortable loudness level can be challenging. The use of electrically evoked auditory brainstem response (ePEATC) and electrically evoked stapedius reflex thresholds (eREE) have been considered for this purpose. Aim: To determine the feasibility of performing ePEATC and eREE on adult and pediatric patients with a cochlear implant, and to evaluate changes in programming following these objective measures. Material and method: A prospective, descriptive study was completed, of patients with MED-EL® cochlear implants, separating patients into two groups: adults (n=5) and children (n=5). All of the patients included had their implants activated for 6 months or longer. Epidemiological variables and duration of implant activation were evaluated. Otoscopy, a basic implant functioning evaluation, and objective measures (ePEATC, eREE) were performed. With these results, comfortable loudness levels were adjusted. Results: Average duration of implant activation was 27 months and 30 months, for adults and children respectively. Performing ePEATC required more time and cooperation as compared to eREE. Following the objective measures, adjustment of the comfortable loudness levels was required for three adult and two pediatric patients. Sound field audiometry was necessary for two pediatric patients in order to estimate the comfortable loudness levels because the eREE responses were absent. Conclusions: It is feasible to perform these objective measures for both adult and pediatric patients, with eREE requiring less time and being better tolerated by patients.

RESUMEN Introducción: La programación adecuada de los implantes cocleares permiten lograr niveles de estimulación auditivos óptimos. Se realiza de forma individualizada, siendo la detección del umbral de confort ideal un desafío. Se ha descrito la utilidad de los potenciales auditivos del tronco encefálico eléctrico (ePEATC) y el reflejo eléctrico estapedial (eREE) para este propósito. Objetivo: Determinar la posibilidad de realizar ePEATC y eREE en pacientes adultos y pediátricos con implantes cocleares, y evaluar cambios en la programación de los implantes cocleares luego de las mediciones objetivas. Material y método: Se realizó un estudio prospectivo, descriptivo, de pacientes con implante coclear marca MED-EL®, separando los pacientes en dos grupos: el grupo adulto (n =5) y el grupo pediátrico (n =5). Todos los pacientes incluidos presentaron más de 6 meses de encendido del implante. Se evaluaron variables epidemiológicas y tiempo de encendido del implante. Se realizó una otoscopía, prueba básica de funcionamiento del implante, y las mediciones objetivas eléctricas (ePEATC, eREE). Con estos resultados se ajustó el umbral de confort. Resultados: El tiempo promedio de encendido del implante en el grupo adulto fue de 27 meses, y 30 meses en el grupo pediátrico. El ePEATC requiere más tiempo y cooperación al compararlo con eREE. Luego de estas evaluaciones objetivas, fue necesario el ajuste del umbral de confort en tres pacientes adultos, y en dos pacientes pediátricos. Fue necesario realizar una audiometría de campo libre para estimar el umbral de confort en dos pacientes pediátricos que no presentaron respuesta en eREE. Conclusión: Fue posible realizar estas mediciones objetivas en pacientes adultos y pediátricos, siendo mejor tolerado y requiriendo menos tiempo, el eREE.

Lexical availability (LA) is the area of linguistic research that aims at the collection and subsequent analysis of the available lexicon of a given speech community. In this study we present the results of a research project, which has among its general objectives to quantify and describe the lexicon in high school math students from the city of Concepción-Chile. To this end, the lexical availability model will be used, through a quantitative analysis, considering three indexes: response average (XR), total of different words (PD), and cohesion index (CI). The sample consists of 1,557 students in Concepción. The results show an increase of vocabulary available for the students as they increase their level of education. This was also observed in students of educational institutions of higher socioeconomic status.

La disponibilidad léxica (DL) es el área de investigación lingüística que tiene como objetivo la recogida y el posterior análisis del léxico disponible en una determinada comunidad de hablantes. En este estudio, se presenta los resultados de un proyecto de investigación, que tiene como objetivos cuantificar y describir el léxico disponible en matemáticas de los alumnos de enseñanza media de la ciudad de Concepción-Chile. Para este fin, se utiliza el modelo de disponibilidad léxica a través de un análisis cuantitativo, considerando tres índices: promedio de respuestas (XR), total de palabras diferentes (PD), y el índice de cohesión (IC). La muestra está constituida por 1557 alumnos de la ciudad de Concepción-Chile. Los resultados evidencian un crecimiento del léxico disponible por parte de los alumnos a medida que estos aumentan su nivel de escolaridad.

ParathionÒ is an organophosphorate pesticide amply used in agriculture. Many alterations induced by organophosphorate pesticides have been described, such as: cytogenetic alterations in germinal cells, oligozoospermia and teratozoospermia in the mouse. The effect of ParathionÒ, both pure (PP) and commercial (PC), on mouse interstitial cell testosterone production was evaluated in vivo and in vitro. Male mice were intraperitoneally injected with a single dose of 1/3 LD50 of ParathionÒ, both PP and PC. The animals were sacrificed at 1, 8 and 40 days post injection to evaluate the impact of disrupting testosterone production on spermatogonia, spermatocytes and elongated spermatids. The plasma testosterone was assayed by standard radioimmunoanalysis. The same method was used to assay testosterone in the culture medium of interstitial cells obtained from the control and ParathionÒ treated animals at the same time intervals. Sperm count, sperm teratozoospermia and tubular blockage were analyzed for an appraisal of spermatogenesis. Increase in the teratozoospermia and tubular blockage was detected in the PP and PC group at 8 and 40 days post injection. Plasma testosterone levels drop significantly at 8 days and recovered slowly at 40 days only in PP animals as detected in vivo, implying interference of testicular steroidogenesis due to the toxicant. Recuperation of normality occurs at long time intervals. In conclusion, ParathionÒ disturbs the synthesis of testosterone in mice affecting qualitatively the spermatogenesis.

Giant Cell Granuloma (GCG) is an uncommon condition affecting the bones of the head and neck. The ethiology and pathophysiology are not completely understood. The histlogic characteristics of GCG are benign, but its biologic behavior could locally aggressive. We describe the case of a 6 year-old boy with GCG and performed a review of the entity ant their differential diagnosis with other lesions of the maxillary bones.

El granuloma gigantocelular central (GGCC), es una lesión tumoral o seudotumoral, infrecuente de los huesos de la cabeza y cuello, que afecta más frecuentemente los maxilares. Su etiología y patogenia son poco conocidas, sus características histológicas son benignas y su comportamiento biológico puede ser agresivo localmente. Presentamos el caso de un niño de 6 años con esta afección y realizamos una revisión de la entidad y sus diagnósticos diferenciales con otras lesiones de los maxilares.

Emphasis on correct classification is still a high priority in the literature and yet there remains a great deal of misinformation. Many new developments in the basic science of these lesions are allowing better understanding of why these lesions occur while improving our management in these patients. Advances in early diagnosis and therapeutic experience have improved our ability to treat extensive lesions and also improve patients' quality of life.

Enfatizar en la correcta clasificación es aún una alta prioridad en la literatura ya persiste una gran desinformación al respecto. Nuevos progresos en la ciencia han permitido una mejor comprensión de estas lesiones. El avance en el diagnóstico precoz y la experiencia terapéutica han mejorado nuestra habilidad para tratar lesiones extensas y mejorar la calidad de vida de los pacientes.

In spite of being in the XXI century, several archaic codes of communication language have been restablished. Young people form their identity by peer interaction, and tattoos and piercing have their own codes interpreted by the group by whom are exhibited. Nowadays tattoos and piercing have taken their place among adolescents where they have been reinstalled as "fashion" and widely accepted. Also, there are used in marginal populations such as drug users and prison inmates. Having a tattoo and/or piercing implies certain risks among which we are the transition of infectious diseases that could be localized at the site of the tattoo/piercing, or generalized as viral infections such HIV, and hepatitis A, B, or C. Other possible complications are the appearance of allergic, hypersensitivity, lichenoid, and granulomatous reactions, or the triggering of a first episode of psoriasis, lupus, etc. In the recommendations to inform the population we should include that the body regions more unsafe for these practices are: the head (including mouth and nose), neck, and genitalia. Is also very important to have tetanus vaccines updated, considering the hygiene conditions of the tattoo parlor and the quality of the material that is going to be used which should be disposable if possible. The local care in the first days post-practice are: keeping the region clean and dry, short showers, dry without rubbing, and avoid the sun for three or four months. Also is advisable in the case of any reaction seek for professional advice.

A pesar de estar en el siglo XXI se ha retomado el lenguaje con códigos de comunicación arcaicos. Los jóvenes forman su identidad mediante la interacción con sus pares y los tatuajes y "piercing" tienen sus propios códigos, que son interpretados por el grupo que los lleva. Actualmente los tatuajes y los "piercing" encuentran su lugar predominante en la población adolescente, donde se han reinstalado por ser "moda" y generalmente se aceptan por estar generalizados. Asimismo los observamos en poblaciones marginales: de drogadictos y carcelarias. Realizarse un tatuaje y/o "piercing" implica ciertos riesgos, entre los que podemos mencionar la transmisión de infecciones que pueden ser localizadas en las zonas del tatuaje y/o "piercing"; y/o generalizadas como las virósicas algunas de las cuales conllevan riesgos de salud como el virus del HIV, de las hepatitis A,B,C. Pueden observarse también reacciones alérgicas, de hipersensibilidad, liquenoides, granulomatosas y varias como cicatrices hipertróficas y queloides; asimismo desencadenar un primer episodio de psoriasis, lupus, etc. Dentro de las recomendaciones para informar a la población deberíamos incluir: que las regiones del cuerpo más riesgosas para la realización de los mismos (que debieran evitarse) son aquellas que asientan en cabeza (incluyendo boca, nariz), cuello y órganos genitales. También es importante tener la vacunación antitetánica actualizada, considerar las condiciones de higiene del local donde se va a asistir y el tipo de material a utilizar, debiendo ser en lo posible material descartable. Los cuidados durante los primeros días post práctica son: mantener la zona limpia y seca, baños cortos, secarse sin frotado y no exponerse al sol por tres o cuatro meses. Asimismo es aconsejable ante cualquier reacción concurrir a la consulta profesional.

A locality in the district of Tlalpan, Mexico City, was selected in order to identify the viral agents in children younger than 5 years of age with acute respiratory infection (ARI). A total of 300 children were randomly selected and were included in this study for a period of 13 months. During this period nasopharyngeal exudates were collected for the isolation of viral agents. Monoclonal fluorescent antibodies were used for viral identification after cell culture. Viral infection was detected in 65% of the specimens. The respiratory syncytial virus (RSV) was the most common virus agent detected. Children required an average of two consultations during the study period. Two high incidence peaks were observed, one during the summer and the other during winter; the most frequent viruses during these seasons were influenza A and RSV, respectively. The largest number of viruses was isolated in the group of children between 1 and 2 years of age and in the group between 4 and 5 years of age. This study demonstrated the presence of ARI and of different viruses in a period of 13 months, as well as the most frequent viruses in children younger than 5 years of age from a community of Mexico City.

O presente trabalho foi realizado na área urbana e rural da cidade de Santa Teresa, localizada no município de Santa Teresa, Estado do Espírito Santo, Brasil, com o objetivo de identificar as espécies vegetais medicinais utilizadas por benzedores e outros informantes. Um levantamento qualitativo, por meio de conversas informais e do método de observação participante foi desenvolvido junto à 14 moradores locais, escolhidos de forma aleatória ou pelo método "bola de neve". Considerou-se cinco destes moradores como colaboradores-chave por serem usuários de plantas medicinais, aos quais foram conduzidas entrevistas estruturadas e semi-estruturadas. O material botânico coletado foi depositado no Herbário do Departamento de Botânica do Museu Nacional (R). Registrou-se o uso de 62 etnoespécies, sendo todas Angiospermas e, em sua maioria, de porte herbáceo. Para a cura de enfermidades os benzedores fazem orações e indicam espécies vegetais, cuja forma de preparo mais comum foi a decocção e a parte da planta mais utilizada foram as folhas.

The present work was carried through in the urban and rural area of the city of Santa Teresa, located in the Santa Teresa County, State of Espirito Santo, Brazil, with the objective to identify the medicinal vegetal species used by healers and other informants. A qualitative survey, by means of informal conversation and of the participant observation method was developed together the 14 local inhabitants, chosen of random form or by the "snow ball" method. Five of these inhabitants were considered as keycollaborators for being usuary of medicinal plants, to which structured and semi-structured interviews had been lead. The collected botanical material was deposited in the Herbarium of the Botanical Department of the National Museum (R), Brazil. The use of 62 ethnospecies was registered, being all Angiosperms and, in its majority, herbs. For the cure of diseases the healers make prayers and indicate vegetal species, whose more common form of preparation was the decoction and the more used part of the plant had been the leves.