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Quality of emergency oncological surgery: time for advanced oncological life support surgery
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Ferreira, Fábio de Oliveira

; Lima, Tibério Moura de Andrade

; Utiyama, Edivaldo Massazo

; Oliveira, Alexandre Ferreira

; Von Bahten, Luiz Carlos

; Ribeiro, Heber Salvador de Castro

Revista da Associação Médica Brasileira

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2024, Volume 70 Supl. 1 elocation e2024S109

Resumo: En | Texto: En | PDF: En

SUMMARY In the emergency care of cancer patients, in addition to cancer-related factors, two aspects influence the outcome: (1) where the patient is treated and (2) who will perform the surgery. In Brazil, a significant proportion of patients with surgical oncological emergencies will be operated on in general hospitals by surgeons without training in oncological surgery. OBJECTIVE: The objective was to discuss quality indicators and propose the creation of an urgent oncological surgery advanced life support course. METHODS: Review of articles on the topic. RESULTS: Generally, nonelective resections are associated with higher rates of morbidity and mortality, as well as lower rates of cancer-specific survival. In comparison to elective procedures, the reduced number of harvested lymph nodes and the higher rate of positive margins suggest a compromised degree of radicality in the emergency scenario. CONCLUSION: Among modifiable factors is the training of the emergency surgeon. Enhancing the practice of oncological surgery in emergency settings constitutes a formidable undertaking that entails collaboration across various medical specialties and warrants endorsement and support from medical societies and educational institutions. It is time to establish a national registry encompassing oncological emergencies, develop quality indicators tailored to the national context, and foster the establishment of specialized training programs aimed at enhancing the proficiency of physicians serving in emergency services catering to cancer patients. cancerrelated related outcome 1 (1 2 (2 Brazil OBJECTIVE course METHODS topic RESULTS Generally mortality cancerspecific specific survival procedures scenario CONCLUSION surgeon institutions context (

https://doi.org/10.1590/1806-9282.2024s109

Surgical complications in the first and second semesters of the general surgery medical residence. A study of 14063 cases residence 1406 140 14 1
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Alvarenga, Bruno Henrique

; Rios, Izabel Cristina

; Silva, Francisco de Salles Collet e

; Utiyama, Edivaldo Massazo

Clinics

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2024, Volume 79 elocation 100351

Resumo: En | Texto: En | PDF: En

Abstract Objective: To evaluate whether the rate of surgical complications is higher during the first semester of the General Surgery residency in the largest hospital complex in Latin America. During this period, students are expected to have less experience in carrying out procedures. Methods: During a period of two years, all General Surgery resident doctors at the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo, made a notification of all the procedures they performed (n = 14.063), containing information such as name of the procedure, date, who participated, complications, among others. These data were analyzed with the purpose of evaluating the variation in the rate of complications throughout the year. Results: There was a 52 % increase in the rate of complications in the first academic semester when compared to the second semester. This phenomenon was observed in resident doctors in the first and second years of residency. Furthermore, it was observed that second-year residents remain with high rates of complications, in some procedures, for a longer time than first-year residents. Furthermore, the first three months (March, April and May) seem to have the highest complication rates of the entire year. Conclusion The impact of these complications can affect several health services and the increase in surgical complications in the first half of the year must be monitored by institutions, in order to control this phenomenon. Objective America Methods Paulo n 14.063, 14063 14.063 , 14 063 14.063) procedure date participated others Results 5 Furthermore secondyear firstyear March, March (March May institutions 1406 14.06 1 06 140 14.0 0 14.

https://doi.org/10.1016/j.clinsp.2024.100351

Low-cost wound protector for laparoscopic surgeries Lowcost Low cost
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MENEGOZZO, CARLOS AUGUSTO METIDIERI

; OLIVEIRA, CRISTIANE PRESTES DA ROSA

; RASSLAN, ROBERTO

; KFOURI, FELIPE

; BITRAN, ALBERTO

; LEAL, RENATO SILVEIRA

; DAMOUS, SERGIO HENRIQUE BASTOS

; UTIYAMA, EDIVALDO MASSAZO

Revista do Colégio Brasileiro de Cirurgiões

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2024, Volume 51 elocation e20243765

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O papel dos protetores de ferida operatória em cirurgias laparoscópicas é bastante controverso na literatura. Alguns estudos demonstram seu benefício na redução da taxa de infeções de sítio cirúrgico, porém esses resultados não são reprodutíveis em todos os procedimentos. Além da proteção da ferida operatória, esses dispositivos podem ser utilizados nos sítios de extração de peças cirúrgicas em procedimentos laparoscópicos. Há vários dispositivos comercialmente disponíveis para esse fim, entretanto são pouco disponíveis nos serviços com menos recursos. Um dos motivos dessa limitação é o custo do dispositivo. Nesta nota, buscamos oferecer uma opção barata que utiliza materiais amplamente disponíveis no centro cirúrgico e cuja confecção é simples. literatura laparoscópicos fim recursos dispositivo nota simples

ABSTRACT The role of wound protectors in laparoscopic surgeries is highly controversial in the literature. Some studies demonstrate their benefit in reducing the rate of surgical site infections; however, these results are not reproducible across all procedures. In addition to protecting the operative wound, these devices can be used at sites of surgical specimen extraction in laparoscopic procedures. Several commercially available devices serve this purpose but are scarcely available in resource-limited settings. One of the reasons for this limitation is the cost of the device. In this technical note, we aim to provide a cost-effective option utilizing materials readily available in the operating room and with a simple fabrication process. literature infections however procedures resourcelimited resource limited settings device note costeffective effective process

https://doi.org/10.1590/0100-6991e-20243765-en

Association of antimicrobial use and incidence of hospital-acquired pneumonia in critically ill trauma patients with pulmonary contusion: an observational study hospitalacquired hospital acquired contusion
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Bassi, Estevão

; Merighi, Camila Trevizani

; Tomizuka, Carlos Issamu

; Guimarães, Thais

; Novo, Fernando da Costa Ferreira

; Damous, Sergio Henrique Bastos

; Utiyama, Edivaldo Massazo

; Malbouisson, Luiz Marcelo Sá

Brazilian Journal of Anesthesiology

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2024, Volume 74 Nº 3 elocation 744454

Resumo: En | Texto: En | PDF: En

Abstract Background: Pneumonia occurs in about 20% of trauma patients with pulmonary contusions. This study aims to evaluate the association between empirical antibiotic therapy and nosocomial pneumonia in this population. Methods: Retrospective cohort of adult patients admitted to a trauma-surgical ICU. The Antibiotic Therapy Group (ATG) was defined by intravenous antibiotic use for more than 48 h starting on hospital admission, while the Conservative Group (CG) was determined by antibiotic use no longer than 48 h. Primary outcome was microbiologically documented nosocomial pneumonia within 14 days after hospital admission. Logistic regression was used to estimate the association between group allocation and primary outcome. Exploratory analyses evaluating the association between resistant strains in pneumonia and antibiotic use were performed. Results: The study included 177 patients with chest trauma and pulmonary contusion on CTscan. ATG were more severely ill than CG, as shown by higher Injury Severity Score, SAPS3, SOFA score, higher rates, and longer duration of mechanical ventilation. In the multivariate analysis, ATG was associated with a lower incidence of primary outcome (OR = 0.25, 95% CI 0.09-0.64; p < 0.01). Similar results were found in the sensitivity analysis with another set of variables. However, each day of antibiotic use was associated with an increased risk of pneumonia by resistant bacteria (OR = 1.18 per day, 95% CI 1.05-1.36; p < 0.01). Conclusions: Empiric antibiotic therapy was independently associated with lower incidence of nosocomial pneumonia in critically ill patients with pulmonary contusion. However, each day of antibiotic use was associated with increased resistant strains in infected patients. Background 20 contusions population Methods traumasurgical surgical ICU (ATG 4 admission CG (CG 1 performed Results 17 CTscan Score SAPS3 SAPS score rates ventilation OR 025 0 25 0.25 95 0.090.64 009064 0.09 0.64 09 64 0.09-0.64 0.01. 001 0.01 . 01 0.01) variables However 118 18 1.1 1.051.36 105136 1.05 1.36 05 36 1.05-1.36 Conclusions 2 02 0.2 9 090 0.090.6 00906 009 0.0 064 0.6 6 0.09-0.6 00 11 1. 051 1.051.3 10513 105 1.0 136 1.3 3 1.05-1.3 0. 0.090. 0090 06 0.09-0. 1.051. 1051 10 13 1.05-1. 0.090 0.09-0 1.051 1.05-1 0.09- 1.05-

https://doi.org/10.1016/j.bjane.2023.07.011

Impact of withholding early antibiotic therapy in nonseptic surgical patients with suspected nosocomial infection: a retrospective cohort analysis infection
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Bassi, Estevão

; Tomazini, Bruno Martins

; Carneiro, Bárbara Vieira

; Siqueira, Amanda Rodrigues de Oliveira

; Siqueira, Sara Rodrigues de Oliveira

; Guimarães, Thais

; Novo, Fernando da Costa Ferreira

; Utiyama, Edivaldo Massazo

; Pelosi, Paolo

; Malbouisson, Luiz Marcelo Sá

Brazilian Journal of Anesthesiology

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2024, Volume 74 Nº 3 elocation 744431

Resumo: En | Texto: En | PDF: En

Abstract Background: Systemic inflammatory responses mimicking infectious complications are often present in surgical patients. Methods: The objective was to assess the association between withholding early antimicrobial therapy while investigating alternative diagnoses and worse outcomes in nonseptic patients with suspected nosocomial infection in a retrospective cohort of critically ill surgical patients. The initiation of antibiotic therapy within 24 h of the suspicion of infection was defined as the Early Empirical Antibiotic strategy (EEA) group and the initiation after 24 h of suspicion or not prescribed was defined as the Conservative Antibiotic strategy (CA) group. Primary outcome was composite: death, sepsis, or septic shock within 14 days. Main exclusion criteria were sepsis or an evident source of infection at inclusion. Results: Three hundred and forty patients were eligible for inclusion (74% trauma patients). Age, sex, reason for hospital admission, SAPS3 score, SOFA score, and use of vasopressors or mechanical ventilation were not different between the groups. Within 14 days of inclusion, 100% (130/130) of EEA patients received antibiotics compared to 57% (120/210) of CA patients. After adjusting for confounding variables, there was no association between primary outcome and the groups. In a post hoc subgroup analysis including only patients with a posteriori confirmed infection (by microbiological cultures), delay in initiation of adequate antimicrobial therapy was independently associated with the primary outcome (Odds Ratio = 1.19 per day of delay; 95% CI 1.05–1.37). Conclusions: Withholding early empiric antibiotic therapy was not associated with progression of organ dysfunction within 14 days in nonseptic surgical patients with suspected nosocomial infection without an obvious source. Background Methods 2 (EEA (CA composite death 1 Results 74% 74 (74 . patients) Age sex admission SAPS score groups 100 130/130 130130 130 (130/130 57 120/210 120210 120 210 (120/210 variables by cultures, cultures , cultures) Odds 119 19 1.1 95 1.05–1.37. 105137 1.05–1.37 05 37 1.05–1.37) Conclusions 7 (7 10 130/13 13013 13 (130/13 5 120/21 12021 12 21 (120/21 11 1. 9 10513 1.05–1.3 0 3 ( 130/1 1301 (130/1 120/2 1202 (120/2 1051 1.05–1. 130/ (130/ 120/ (120/ 105 1.05–1 (130 (120 1.05– (13 (12 1.05 (1 1.0

https://doi.org/10.1016/j.bjane.2023.03.003

Resource management strategies for prioritizing non-scheduled surgical procedures in a tertiary public hospital nonscheduled non scheduled
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Rocha, Marcelo Cristiano

; Costa, Rafaela Alkmin da

; Utiyama, Edivaldo Massazo

Clinics

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2024, Volume 79 elocation 100482

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1016/j.clinsp.2024.100482

Challenges to implement laparoscopic appendectomy as the first-line treatment for acute appendicitis: a fifteen-year experience in a tertiary hospital in Brazil firstline first line appendicitis fifteenyear fifteen year
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DAMOUS, SERGIO HENRIQUE BASTOS

; MENEGOZZO, CARLOS AUGUSTO METIDIERI

; ROCHA, MARCELO CRISTIANO

; COLLET-E-SILVA, FRANCISCO SALLES

; UTIYAMA, EDIVALDO MASSAZO

Revista do Colégio Brasileiro de Cirurgiões

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2023, Volume 50 elocation e20233527

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: o presente estudo tem como objetivo avaliar as medidas que permitiram a implementação de cirurgias laparoscópicas de urgência em hospital de ensino médico ao longo de 15 anos. Método: foi realizado estudo clínico retrospectivo de pacientes submetidos a Apendicectomia aberta ou Laparoscópica no período de 15 anos (2004 a 2018). Os dados clínicos foram confrontados com as ações implementadas: 1) Treinamento dos médicos residentes em cirurgia minimamente invasiva (2007); 2) Uso do endoclip para tratamento do coto apendicular (2008); 3) Disponibilidade do set de laparoscopia em tempo integral para o Pronto Socorro (2010); e, 4) Terceirização do serviço de manutenção do set e materiais de vídeo e uso do endoclip Hem-o-lok® para tratamento do coto apendicular (2013). Resultados: foram realizadas 1.168 cirurgias, das quais 691 abertas (59%), 465 laparoscopias (40%) e 12 convertidas (1%). O treinamento da equipe levou à realização de 11% de laparoscopia (2007) e o uso do endoclip para tratamento do coto apendicular para 16% (2008). Com a disponibilização do set de vídeo em tempo integral para o Pronto Socorro a partir de 2011, houve aumento de laparoscopias para 26% (2012). A padronização do endoclip Hem-o-lok® no tratamento do coto apendicular aumentou para 85% e a partir de 2016 foi realizado em todos os casos, sem complicação relacionada ao seu uso, mesmo em apendicites complicadas. Conclusão: o emprego da laparoscopia no serviço de urgência envolve além do treinamento da equipe cirúrgica, investimento tecnológico contínuo e uso de técnicas que sejam factíveis, viáveis e seguras. Introdução 1 Método 2004 (200 2018. 2018 . 2018) implementadas 2007 2 2008 (2008) 3 2010 (2010) 4 Hemolok® Hemolok Hem lok® lok Hem-o-lok 2013. 2013 (2013) Resultados 1168 168 1.16 69 59%, 59 59% , (59%) 46 40% 40 (40% 1%. 1% (1%) 11 (2007 16 2008. 2011 26 2012. 2012 (2012) 85 201 casos complicadas Conclusão cirúrgica factíveis seguras 200 (20 (2008 (2010 (2013 116 1.1 6 5 (59% (40 (1% (2012 8 20 (2 (201 1. (59 (4 (1 ( (5

ABSTRACT Background: the barriers to implement emergency laparoscopy in public teaching hospitals involve issues such as resident learning curves and resource costs and availability. This study was designed to describe the issues facing the implementation of laparoscopic approach for acute appendicitis over 15 years in a single academic center in Brazil. Materials and Methods: retrospective study of patients undergoing emergency appendectomy from 2004 to 2018. Clinical data were compared to four major actions implemented in the emergency surgical service: minimally invasive surgery training for residents (2007), laparoscopic stump closure using metal clips (2008), 24/7 availability of laparoscopic instruments for emergency surgeries (2010), and third-party contract for maintenance of the laparoscopic instruments and implementation of polymeric clips for stump closure (2013). We evaluated the increase in laparoscopic appendectomy after the implementation of those major changes. Results: we identified 1168 appendectomies during the study period, of which 691 (59%), 465 (40%), and 12 (1%) were open, laparoscopic, and converted, respectively. The implementation of the major changes since 2004 resulted in an increase of laparoscopic appendectomies from 11% in 2007 to 80% in 2016. These actions were decisive in the widespread use of laparoscopy for acute appendicitis (p<0.001). The standardization of the hem-o-lok clip in the treatment of the appendiceal stump made the procedure more feasible, reducing the surgical time using laparoscopic access and increasing the team’s adherence, so that this became the route of choice in about 85% of cases in the period from 2014 to 2018, 80% performed by 3rd year resident physicians. No intraoperative complications were noted related to laparoscopic access, even in more complicated appendicitis. There was no mortality reported, no reoperations or readmissions to hospital during a 30-day postoperative period. Conclusion: the development of a feasible, reproducible, and safe technical standardization, associated with continuous cost optimization, are the cornerstones for a consistent and viable change in the current practice for appendectomies in middle and lower-income countries. Background 1 Brazil Methods 200 2018 service 2007, , (2007) 2008, 2008 (2008) 247 24 7 24/ 2010, 2010 (2010) thirdparty third party 2013. 2013 . (2013) Results 116 69 59%, 59 59% (59%) 46 40%, 40 40% (40%) 1% (1% open converted respectively 11 80 2016 p<0.001. p0001 p p<0.001 0 001 (p<0.001) hemolok hem o lok feasible teams team s adherence 85 201 rd physicians reported 30day day 30 Conclusion reproducible optimization lowerincome lower income countries 20 (2007 (2008 2 (2010 (2013 6 5 (59% 4 (40% (1 8 p000 p<0.00 00 (p<0.001 3 (200 (201 (59 (40 ( p00 p<0.0 (p<0.00 (20 (5 (4 p0 p<0. (p<0.0 (2 p<0 (p<0. p< (p<0 (p< (p

https://doi.org/10.1590/0100-6991e-20233527-en

Laparoscopy in Trauma: Can Brazil fit into the global trend? Trauma trend
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DAMOUS, SERGIO HENRIQUE BASTOS

; MENEGOZZO, CARLOS AUGUSTO METIDIERI

; VON-BAHTEN, LUIZ CARLOS

; UTIYAMA, EDIVALDO MASSAZO

Revista do Colégio Brasileiro de Cirurgiões

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2023, Volume 50 elocation e20233602EDIT01

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/0100-6991e-20233602edit01-en

Predictive factors of mortality in patients with pelvic fracture and shock submitted to extraperitoneal pelvic packing
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FONSECA, VINICIUS CORDEIRO

; MENEGOZZO, CARLOS AUGUSTO METIDIERI

; CARDOSO, JULIANA MYNSSEN DA FONSECA

; BERNINI, CELSO OLIVEIRA

; UTIYAMA, EDIVALDO MASSAZO

; POGGETTI, RENATO SÉRGIO

Revista do Colégio Brasileiro de Cirurgiões

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2022, Volume 49 elocation e20223259

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: nas últimas décadas, tem sido difundida a técnica de tamponamento pélvico extraperitoneal, porém ainda existem poucos estudos. Decidiu-se analisar os resultados do tamponamento extraperitoneal de pelve, em pacientes com fratura pélvica e choque, com objetivo de identificar fatores preditivos de mortalidade. Métodos: foi realizada revisão do prontuário dos pacientes submetidos ao tamponamento extraperitoneal de pelve. Foram analisadas as características dos pacientes, dados do atendimento pré-hospitalar e na sala de emergência, classificação da fratura, presença de lesões associadas, exames laboratoriais e de imagem, dados relativos ao tamponamento, e outros procedimentos realizados, complicações, parâmetros hemodinâmicos e quantidade de hemoderivados transfudidos. Resultados: foram analisados os dados de 51 pacientes, com sinais de choque desde o atendimento pré-hospitalar, presença de acidose, elevado déficit de bases e lactato arterial. Houve alta prevalência de lesões graves associadas, requerendo múltiplos procedimentos cirúrgicos. A incidência de coagulopatia foi 70,58% e mortalidade 56,86%. O grupo de pacientes não sobreviventes apresentou idade e intubação orotraqueal pré-hospitalar maiores, e escores na escala de coma de Glasgow menores (p<0,05). O mesmo grupo apresentou, antes e após o tamponamento extraperitoneal de pelve, parâmetros hemodinâmicos menores de pressão arterial média, pH, déficit de bases e hemoglobina, e maior de lactato arterial (p<0,05). O grupo de pacientes não sobreviventes recebeu mais concentrados de hemácias, plasma fresco congelado e concentrado de plaquetas nas 24h seguintes ao tamponamento extraperitoneal de pelve (p<0,05). Conclusão: idade e o excesso de bases são fatores preditivos independentes de mortalidade em pacientes submetidos ao tamponamento extraperitoneal de pelve.

ABSTRACT Introduction: in recent decades, the extraperitoneal pelvic packing technique has been disseminated, but there are still few studies. Thus, it was decided to analyze the results of extraperitoneal pelvic tamponade, in patients with pelvic fracture and shock, in order to identify predictive factors for mortality. Methods: a retrospective review of medical records of patients submitted to extraperitoneal pelvic packing was conduced. We analyzed their characteristics, prehospital and emergency room data, pelvic fracture classification, associated and severity injuries, laboratory and imaging exams, data on packing, arteriography, and other procedures performed, complications, hemodynamic parameters, and amount of transfused blood products before and after packing. Results: data were analyzed from 51 patients, who showed signs of shock from prehospital care, presence of acidosis, with high base deficit and arterial lactate levels. Most patients underwent multiple surgical procedures due to severe associated injuries. The incidence of coagulopathy was 70.58%, and overall mortality was 56.86%. The group of non-surviving patients presented significantly higher age, prehospital endotracheal intubation, and lower Glasgow Coma Scale scores (p<0.05). The same group presented, before and after extraperitoneal pelvic packing, significantly worse hemodynamic parameters of mean arterial pressure, pH, base deficit, hemoglobin, and arterial lactate (p<0.05). The non-surviving group received significantly more units of packed red blood cells, fresh frozen plasma and platelets within 24 hours following extraperitoneal pelvic packing (p<0.05). Conclusion: age and base deficit are independent predictors of mortality in patients submitted to extraperitoneal pelvic packing.

https://doi.org/10.1590/0100-6991e-20223259-en

10.

Safe ultrasound-guided percutaneous tracheostomy in eight steps and necessary precautions in COVID-19 patients
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MENEGOZZO, CARLOS AUGUSTO METIDIERI

; SORBELLO, CAROLINA CARVALHO JANSEN

; SANTOS-JR, JONES PESSOA

; RASSLAN, ROBERTO

; DAMOUS, SERGIO HENRIQUE BASTOS

; UTIYAMA, EDIVALDO MASSAZO

Revista do Colégio Brasileiro de Cirurgiões

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2022, Volume 49 elocation e20223202

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A traqueostomia percutânea tem sido considerada o método padrão atualmente, sendo a técnica guiada por broncoscopia a mais realizada. Uma alternativa segura é a traqueostomia percutânea guiada por ultrassonografia, que pode ser feita pelo próprio cirurgião, evitando-se as dificuldades logísticas de disponibilidade de um especialista em broncoscopia. Estudos comprovam que a eficácia e a segurança da técnica guiada por ultrassonografia, comparada à guiada por broncoscopia, são semelhantes. Assim, é de suma importância que os cirurgiões tenham a traqueostomia percutânea guiada por ultrassonografia como alternativa viável e benéfica em relação ao procedimento aberto. Neste artigo, descrevemos oito passos principais da realização da traqueostomia percutânea ecoguiada, destacando pontos técnicos essenciais que podem reduzir o risco de complicações do procedimento. Ainda, detalhamos alguns cuidados que devem ser observados, com o intuito de reduzir o risco de aerolização e contaminação da equipe, quando a traqueostomia percutânea é indicada no paciente com COVID-19.

ABSTRACT Percutaneous tracheostomy has been considered the standard method today, the bronchoscopy-guided technique being the most frequently performed. A safe alternative is ultrasound-guided percutaneous tracheostomy, which can be carried out by the surgeon, avoiding the logistical difficulties of having a specialist in bronchoscopy. Studies prove that the efficacy and safety of the ultrasound-guided technique are similar when compared to the bronchoscopy-guided one. Thus, it is of paramount importance that surgeons have ultrasound-guided percutaneous tracheostomy as a viable and beneficial alternative to the open procedure. In this article, we describe eight main steps in performing ultrasound-guided percutaneous tracheostomy, highlighting essential technical points that can reduce the risk of complications from the procedure. Furthermore, we detail some precautions that one must observe to reduce the risk of aerosolization and contamination of the team when percutaneous tracheostomy is indicated in patients with COVID-19.

https://doi.org/10.1590/0100-6991e-20223202

11.

Transfusion of ABO non-identical platelets increases the severity of trauma patients at ICU admission
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Silva, Adriana Lucia de Oliveira

; Bassolli, Lucas

; Ferreira, Pedro

; Utiyama, Edivaldo

; Dezan, Marcia Regina

; Costa-Neto, Abel

; Conrado, Marina C.A.V

; Oliveira, Valeria Brito

; Bonifácio, Silvia Leão

; Fernandes, Frederico Leon Arrabal

; Rocha, Vanderson

; Mendrone-Júnior, Alfredo

; Dinardo, Carla Luana

Hematology, Transfusion and Cell Therapy

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Set 2021, Volume 43 Nº 3 Páginas 287 - 294

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: Transfusion of ABO-compatible non-identical platelets (PTLs), fresh plasma (FP) and red blood cells (RBCs) has been associated with increased morbidity and mortality of recipients. Trauma victims are frequently exposed to ABO non-identical products, given the need for emergency transfusions. Our goal was to evaluate the impact of the transfusion of ABO non-identical blood products on the severity and all-cause 30-day mortality of trauma patients. Methods: This was a retrospective single-center cohort, which included trauma patients who received emergency transfusions in the first 24 h of hospitalization. Patients were divided in two groups according to the use of <3 or ≥3 ABO non-identical blood products. The patient severity, measured by the Acute Physiology and Chronic Health Evaluation (APACHEII) score at ICU admission, and the 30-day mortality were compared between groups. Results: Two hundred and sixteen trauma patients were enrolled. Of these, 21.3% received ≥3 ABO non-identical blood products (RBCs, PLTs and FP or cryoprecipitate). The transfusion of ≥3 ABO non-identical blood products in the first 24 h of hospitalization was independently associated with a higher APACHEII score at ICU admission (OR = 3.28 and CI95% = 1.48–7.16). Transfusion of at least one unit of ABO non-identical PTLs was also associated with severity (OR = 10.89 and CI95% = 3.38–38.49). Transfusion of ABO non-identical blood products was not associated with a higher 30-day mortality in the studied cohort. Conclusion: The transfusion of ABO non-identical blood products and, especially, of ABO non-identical PLTs may be associated with the greater severity of trauma patients at ICU admission. The transfusion of ABO non-identical blood products in the trauma setting is not without risks.

https://doi.org/10.1016/j.htct.2020.06.011 17 downloads

12.

Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study
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Gonçalves, Fabio Augusto Rodrigues

; Besen, Bruno Adler Maccagnan Pinheiro

; Lima, Clarice Antunes de

; Corá, Aline Pivetta

; Pereira, Antônio José Rodrigues

; Perazzio, Sandro Félix

; Gouvea, Christiane Pereira

; Fonseca, Luiz Augusto Marcondes

; Trindade, Evelinda Marramon

; Sumita, Nairo Massakazu

; Duarte, Alberto José da Silva

; Lichtenstein, Arnaldo

; Bonfa, Eloisa

; Utiyama, Edivaldo M.

; Segurado, Aluisio C.

; Perondi, Beatriz

; Miethke-Morais, Anna

; Montal, Amanda C.

; Harima, Leila

; Fusco, Solange R. G.

; Silva, Marjorie F.

; Rocha, Marcelo C.

; Marcilio, Izabel

; Rios, Izabel Cristina

; Kawano, Fabiane Yumi Ogihara

; Jesus, Maria Amélia de

; Kallas, Ésper George

; Carmo, Carolina

; Tanaka, Clarice

; Souza, Heraldo Possolo de

; Marchini, Julio F. M.

; Carvalho, Carlos

; Ferreira, Juliana C.

; Levin, Anna Sara Shafferman

; Oliveira, Maura Salaroli

; Guimarães, Thaís

; Lázari, Carolina dos Santos

; Sabino, Ester

; Magri, Marcello M. C.

; Barros-Filho, Tarcisio E. P.

; Francisco, Maria Cristina Peres Braido

; Costa, Silvia F.

Clinics

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2021, Volume 76 elocation e3547

Resumo: En | Texto: En | PDF: En

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and these complications can lead to a poorer prognosis. This study aimed to evaluate the association and temporal trends of D-dimer and C-reactive protein (CRP) levels with the incidence of venous thromboembolism (VTE), hospital mortality, and costs among inpatients with COVID-19. METHODS: Data were extracted from electronic patient records and laboratory databases. Crude and adjusted associations for age, sex, number of comorbidities, Sequential Organ Failure Assessment score at admission, and D-dimer or CRP logistic regression models were used to evaluate associations. RESULTS: Between March and June 2020, COVID-19 was documented in 3,254 inpatients. The D-dimer level ≥4,000 ng/mL fibrinogen equivalent unit (FEU) mortality odds ratio (OR) was 4.48 (adjusted OR: 1.97). The CRP level ≥220 mg/dL OR for death was 7.73 (adjusted OR: 3.93). The D-dimer level ≥4,000 ng/mL FEU VTE OR was 3.96 (adjusted OR: 3.26). The CRP level ≥220 mg/dL OR for VTE was 2.71 (adjusted OR: 1.92). All these analyses were statistically significant (p<0.001). Stratified hospital costs demonstrated a dose-response pattern. Adjusted D-dimer and CRP levels were associated with higher mortality and doubled hospital costs. In the first week, elevated D-dimer levels predicted VTE occurrence and systemic inflammatory harm, while CRP was a hospital mortality predictor. CONCLUSION: D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.

https://doi.org/10.6061/clinics/2021/e3547

13.

Non-operative management of blunt splenic trauma: evolution, results and controversies
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MEIRA JÚNIOR, JOSÉ DONIZETI

; MENEGOZZO, CARLOS AUGUSTO METIDIERI

; ROCHA, MARCELO CRISTIANO

; UTIYAMA, EDIVALDO MASSAZO

Revista do Colégio Brasileiro de Cirurgiões

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2021, Volume 48 elocation e20202777

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O baço é um dos órgãos mais frequentemente afetados no trauma abdominal contuso. Desde os trabalhos de Upadhyaya, o tratamento do trauma esplênico vem sofrendo importantes modificações. Atualmente, é consenso que todo trauma esplênico que se apresenta com estabilidade hemodinâmica pode ser tratado inicialmente de forma não operatória, desde que o serviço possua estrutura adequada e o paciente não apresente outras condições que indiquem exploração da cavidade abdominal. Entretanto, vários tópicos permanecem controversos no que diz respeito ao tratamento não operatório (TNO) do trauma esplênico. A angioembolização esplênica é uma ferramenta de grande auxílio no TNO, porém não há consenso sobre suas indicações precisas. Não há uma definição na literatura a respeito da forma como o TNO deve ser conduzido, tampouco a respeito da periodicidade do controle hematimétrico, do limiar de transfusão que define falha do TNO, de quando iniciar a profilaxia contra tromboembolismo venoso, da necessidade de exames de imagem de controle, do período de repouso no leito, e de quando é seguro indicar alta hospitalar. O objetivo desta revisão é analisar de forma crítica a literatura a respeito desse tema, expondo o estado da arte no TNO do trauma esplênico.

ABSTRACT The spleen is one of the most frequently affected organs in blunt abdominal trauma. Since Upadhyaya, the treatment of splenic trauma has undergone important changes. Currently, the consensus is that every splenic trauma presenting with hemodynamic stability should be initially treated nonoperatively, provided that the hospital has adequate structure and the patient does not present other conditions that indicate abdominal exploration. However, several topics regarding the nonoperative management (NOM) of splenic trauma are still controversial. Splenic angioembolization is a very useful tool for NOM, but there is no consensus on its precise indications. There is no definition in the literature as to how NOM should be conducted, neither about the periodicity of hematimetric control, the transfusion threshold that defines NOM failure, when to start venous thromboembolism prophylaxis, the need for control imaging, the duration of bed rest, and when it is safe to discharge the patient. The aim of this review is to make a critical analysis of the most recent literature on this topic, exposing the state of the art in the NOM of splenic trauma.

https://doi.org/10.1590/0100-6991e-20202777 955 downloads

14.

Gynecology and women’s health care during the COVID-19 pandemic: Patient safety in surgery and prevention
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Soares-Júnior, José Maria

; Sorpreso, Isabel C.E.

; Motta, Eduardo Vieira

; Utiyama, Edivaldo Massazo

; Baracat, Edmund Chada

Clinics

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2020, Volume 75 elocation e2063

Resumo: En | Texto: En | PDF: En

https://doi.org/10.6061/clinics/2020/e2063 1477 downloads

15.

Overcoming barriers to providing comprehensive inpatient care during the COVID-19 pandemic
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Miethke-Morais, Anna

; Perondi, Beatriz

; Harima, Leila

; Montal, Amanda C.

; Baldassare, Renato Madrid

; Moraes, Danielle P.

; Pedroso, Lucila

; Ramos, Marcelo C.A.

; Fusco, Solange R.G.

; Pereira, Antonio José

; Barros-Filho, Tarcísio E.P.

; Bonfá, Eloisa

; Utiyama, Edivaldo M.

; Segurado, Aluisio C.

Clinics

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2020, Volume 75 elocation e2100

Resumo: En | Texto: En | PDF: En

https://doi.org/10.6061/clinics/2020/e2100 1240 downloads

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